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Rapid flexible clamping technology with intelligent self-adjustment ability for low rigidity aviation stringer parts 认领 引用
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作者 Te Li Tian Lan +4 位作者 Haibo Liu Keming Li Kuo Liu Qile Bo Yongqing Wang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第2期44-50,共7页
Aviation stringer parts usually serve as the important load-bearing and connecting parts,which are widely used in aviation equipment.In the process of blank forming and transportation,the stringer parts are easy to oc... Aviation stringer parts usually serve as the important load-bearing and connecting parts,which are widely used in aviation equipment.In the process of blank forming and transportation,the stringer parts are easy to occur irregular deformation due to low rigidity feature.In order to ensure the machining accuracy,deformation adjustment by fixtures becomes a key process step before CNC machining.In order to solve the problems of deformation adjustment clamping,the rapid flexible clamping technology with intelligent adjustment ability is developed for a kind of typical aviation stringer parts.Firstly,the process of parts deformation correction is analyzed,and the basic mechanism of clamping and deformation correction is given out.On this basis,a modular intelligent fixture is designed by finite element simulation optimization.The fixture can meet the flexible clamping requirements of stringer parts by increasing or decreasing the arrayed fixture units.Then an intelligent self-adjusting clamping control method based on the fuzzy-PID control theory is proposed,which can realize rapid clamping and deformation correction of aviation stringer parts.Finally,a set of intelligent fixture system is developed and tested.The experiment results prove the effectiveness of the fixture design and self-adjusting clamping control method.Compared with the original fixture,the developed fixture system greatly reduces the labor intensity and improves the clamping efficiency by about 5 times.This research proposes a fixture design and control method for aviation stringer parts,which can realize rapid clamping correction of parts. 展开更多
关键词 Aviation stringer parts Deformation correction Self-adjusting clamping Intelligent fixture
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A new dimensionless number for dynamic plastic deformation analysis of clamped circular plates subjected to underwater blast loading 认领 引用
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作者 Weizheng Xu Yu Huang +4 位作者 Tong Li Hao Tang Yexun Li Hua Fu Xianxu Zheng 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2025年第9期294-302,共9页
A new dimensionless number is proposed for dynamic plastic deformation analysis of clamped circular plates under underwater explosion loads by introducing dimensional analysis method to the basic dynamical governing e... A new dimensionless number is proposed for dynamic plastic deformation analysis of clamped circular plates under underwater explosion loads by introducing dimensional analysis method to the basic dynamical governing equations of circular plates.The relation between dimensionless final plastic deformation of circular plates and the new dimensionless number is established based on massive underwater explosion test data.Meanwhile,comparative analysis was discussed with two other published dimensionless parameters which indicated the new dimensionless number proposed in this paper is more effective and extensive to predict the dynamic plastic response of circular plates under underwater explosion condition. 展开更多
关键词 Dimensionless number Underwater blast loading Clamped circular plate Dynamic plastic deformation
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Comparison of nonlinear modeling methods for the composite rubber clamp 认领 引用 被引量：1
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作者 Yiming CAO Hui MA +4 位作者 Xumin GUO Bingfeng ZHAO Hui LI Xin WANG Bing WANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第5期763-778,共16页
The cubic stiffness force model(CSFM)and Bouc-Wen model(BWM)are introduced and compared innovatively.The unknown coefficients of the nonlinear models are identified by the genetic algorithm combined with experiments.B... The cubic stiffness force model(CSFM)and Bouc-Wen model(BWM)are introduced and compared innovatively.The unknown coefficients of the nonlinear models are identified by the genetic algorithm combined with experiments.By fitting the identified nonlinear coefficients under different excitation amplitudes,the nonlinear vibration responses of the system are predicted.The results show that the accuracy of the BWM is higher than that of the CSFM,especially in the non-resonant region.However,the optimization time of the BWM is longer than that of the CSFM. 展开更多
关键词 pipeline system nonlinear clamp model composite rubber clamp amplitude-dependent characteristic vibration response experiment
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Maternal Effects of Immediate versus Delayed Umbilical Cord Clamping: A Randomized Clinical Trial 认领 引用
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作者 Gabriela Françoes Rostirolla Maria Alexandrina Zanatta +3 位作者 Charles Francisco Ferreira José Geraldo Lopes Ramos Edimárlei Gonsales Valério Janete Vettorazzi 《Open Journal of Obstetrics and Gynecology》 2021年第11期1500-1511,共12页
OBJECTIVE: To compare maternal preoperative and postoperative hemoglobin variation after cord clamping. METHODS: Randomized clinical trial performed in Porto Alegre, RS from January to December 2012. It was included 3... OBJECTIVE: To compare maternal preoperative and postoperative hemoglobin variation after cord clamping. METHODS: Randomized clinical trial performed in Porto Alegre, RS from January to December 2012. It was included 356 women with habitual risk gestations. In the immediate cord clamping group, the umbilical cord section was realized between 0 and 60 s (group 1) while in the delayed cord clamping group it was realized >60 s (group 2). RESULTS: The mean (±standard deviation [SD]) preoperative hemoglobin was 12.13 ± 1.06 in the group 1 and 12.13 ± 1.11 in the group 2. The mean (±SD) postoperative day 2 hemoglobin level was 10.19 ± 1.46 in the group 1 and 10.24 ± 1.42 in the group 2. CONCLUSIONS: Delayed umbilical cord clamping resulted in a similar maternal hemoglobin level reduction at postoperative day 2. 展开更多
关键词 Cord Clamping Delayed Cord Clamping Immediate Cord Clamping Matern Hemoglobin Level
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Clamping force of a multilayered cylindrical clamper with internalfriction 认领 引用
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作者 Bo-Hua Sun Xiao-Lin Guo 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2022年第5期301-305,共5页
Holding an object by clamping force is a fundamental phenomena.Layered or laminated architectures with internal sliding features are essential mechanism in natural and man-made structural system.In this paper,we combi... Holding an object by clamping force is a fundamental phenomena.Layered or laminated architectures with internal sliding features are essential mechanism in natural and man-made structural system.In this paper,we combine the layered architecture and clamping mechanism to form a multilayered clamper and study the clamping force with internal friction.Our investigations show that the clamping force and energy dissipation are very much depend on the number of layers,its geometry and elasticity,as well as internal friction.The central goal of studying the multilayered clamp is not only to predict the clamping force,but also as a representative case to help finding some clue on the universal behaviours of multilayered architectures with internal friction. 展开更多
关键词 Clamping force Multilayer clamper Curvature Bending Friction Dissipation Deflection
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A dynamic modeling approach for nonlinear vibration analysis of the L-type pipeline system with clamps 认领 引用 被引量：21
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作者 Qingdong CHAI Jin ZENG +2 位作者 Hui MA Kun LI Qingkai HAN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第12期3253-3265,共13页
There exists a lot of research on the nonlinear vibration of the pipeline system with different boundary conditions.To the best of our knowledge,little research on the actual constraint of the clamp has been performed... There exists a lot of research on the nonlinear vibration of the pipeline system with different boundary conditions.To the best of our knowledge,little research on the actual constraint of the clamp has been performed.In this paper,according to hysteresis loops of the clamp obtained from experimental test,the simplified bilinear stiffness and damping model is proposed.Then the Finite Element(FE)model of L-type pipeline system with clamps is established using Timoshenko beam theory in combination with aforementioned stiffness-damping model.Both hammering and shaker tests verify the FE model via the comparisons of natural frequencies and vibration responses.The results show that the maximum errors of natural frequencies and vibration responses are about 8.31%and 17.6%,respectively.The proposed model can simulate the dynamic characteristics of the L-type pipeline system with clamps well,which is helpful to provide some guidance for the early design stage of pipeline in aero-engine. 展开更多
关键词 Clamp Dynamic modeling Experimental test Finite element Nonlinear vibration Pipeline
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Pipelines vibration analysis and control based on clamps'locations optimization of multi-pump system 认领 引用 被引量：13
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作者 Xin LI Weihao LI +2 位作者 Jian SHI Qiang LI Shaoping WANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第6期352-366,共15页
The violent vibration of hydraulic pipelines in aircraft may cause faults or even an accident,especially for the large aircraft with the multi-pump system because of different vibration sources and complex pipelines s... The violent vibration of hydraulic pipelines in aircraft may cause faults or even an accident,especially for the large aircraft with the multi-pump system because of different vibration sources and complex pipelines system.Aiming to the vibration analysis and control of the multipump system,this paper proposed the clamps’locations optimization to minimize the system impedance at vibration frequencies.Firstly,the models of the flexible clamp and other components in multi-pump system were established,based on which,the system impedance was calculated by using Transfer Matrix Method(TMM);Secondly,the objective function is defined as weighted sum of system impedance at frequencies of different vibration sources.Then,the clamps’locations were altered to change the system impedance.Moreover,The Chaotic Swarm Particle Optimization(CPSO)algorithm was applied to obtain the optimal clamps’locations and the minimum value of objective function which decreased by 36.4%compared to the value of original clamps’locations;Finally,the experiments from vibration and pressure test with original and optimized clamps’locations verified the effectiveness of the system impedance calculation and clamps’locations optimization method. 展开更多
关键词 Clamp CPSO Impedance Multi-pump Pipeline TMM Vibration
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Plastic Mechanism of Multi-pass Double-roller Clamping Spinning for Arc-shaped Surface Flange 认领 引用 被引量：7
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作者 FAN Shuqin ZHAO Shengdun +1 位作者 ZHANG Qi LI Yongyi 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第6期1127-1137,共11页
Compared with the conventional single-roller spinning process, the double-roller clamping spinning（DRCS） process can effectively prevent the sheet metal surface wrinkling and improve the the production efficiency an... Compared with the conventional single-roller spinning process, the double-roller clamping spinning（DRCS） process can effectively prevent the sheet metal surface wrinkling and improve the the production efficiency and the shape precision of final spun part. Based on ABAQUS/Explicit nonlinear finite element software, the finite element model of the multi-pass DRCS for the sheet metal is established, and the material model, the contact definition, the mesh generation, the loading trajectory and other key technical problems are solved. The simulations on the multi-pass DRCS of the ordinary Q235A steel cylindrical part with the arc-shaped surface flange are carried out. The effects of number of spinning passes on the production efficiency, the spinning moment, the shape error of the workpiece, and the wall thickness distribution of the final part are obtained. It is indicated definitely that with the increase of the number of spinning passes the geometrical precision of the spun part increases while the production efficiency reduces. Moreover, the variations of the spinning forces and the distributions of the stresses, strains, wall thickness during the multi-pass DRCS process are revealed. It is indicated that during the DRCS process the radical force is the largest, and the whole deformation area shows the tangential tensile strain and the radial compressive strain, while the thickness strain changes along the generatrix directions from the compressive strain on the outer edge of the flange to the tensile strain on the inner edge of the flange. Based on the G-CNC6135 NC lathe, the three-axis linkage computer-controlled experimental device for DRCS which is driven by the AC servo motor is developed. And then using the experimental device, the Q235A cylindrical parts with the arc-shape surface flange are formed by the DRCS. The simulation results of spun parts have good consistency with the experimental results, which verifies the feasibility of DRCS process and the reliability of the finite element model for DRCS. 展开更多
关键词 spinning double-roller clamping multi-pass arc-shaped surface
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基于Clamped B样条的空间非合作目标抓捕策略研究 认领 引用 被引量：7
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作者 王明明 罗建军 余敏 《力学学报》 EI CAS CSCD 北大核心 2021年第2期524-538,I0004,共15页
空间机械臂技术是未来实施在轨服务与维护任务的关键技术之一.利用机械臂对空间非合作目标,特别是翻滚目标的抓捕仍然存在巨大的挑战.本文提出一种基于Clamped B样条的空间非合作目标抓捕策略方案.在对非合作目标与空间机械臂运动学与... 空间机械臂技术是未来实施在轨服务与维护任务的关键技术之一.利用机械臂对空间非合作目标,特别是翻滚目标的抓捕仍然存在巨大的挑战.本文提出一种基于Clamped B样条的空间非合作目标抓捕策略方案.在对非合作目标与空间机械臂运动学与动力学分析的基础上,结合非合作目标被空间机械臂抓捕后的动静态对偶性分析,构建抓捕后的力可操作度椭球作为抓捕策略设计的优化指标.其次,考虑目标的运动预测和空间机械臂的抓捕能力图谱构建,确定空间机械臂应对目标的最优抓捕时机与抓捕终端状态.基于Clamped B样条对空间机械臂各关节轨迹进行时间归一化参数描述,并对抓捕过程中的机械臂关节角、速度、避撞、抓捕走廊等约束进行数学变换,最终将抓捕策略转换为多约束、多目标的非线性优化问题,利用自适应惯性权重的粒子群优化算法进行求解.将所设计的抓捕策略应用于空间七自由度运动学冗余机械臂,实现了对空间中翻滚目标的成功捕获,验证了所提抓捕策略的可行性与有效性. 展开更多
关键词 抓捕策略 Clamped B样条 空间机械臂 抓捕能力图谱
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Effect of Asynchronous Adjustments of Clamping Cylinders on Triangular Crack of Slab Castings Under Application of Soft Reduction 认领 引用 被引量：3
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作者 LIU Ke CHANG Yun-he +1 位作者 HAN Zhan-guang ZHANG Jia-quan 《Journal of Iron and Steel Research International》 SCIE CAS CSCD 2013年第2期38-47,共10页
Soft reduction is known to be one of the best ways to improve the internal quality of slab castings such as center segregation, center porosity, centerline or triangular zone cracks, which is based on a proper adoptio... Soft reduction is known to be one of the best ways to improve the internal quality of slab castings such as center segregation, center porosity, centerline or triangular zone cracks, which is based on a proper adoption of the amount of reduction upon the given final solidification zone through roll gap adjustments. The synchronization of the clamping cylinders for roll gap adjustments should be very important to the application of soft reduction, including the synchronization of the clamping cylinders adjustments in the same and different segments. The synchronization of clamping cylinders adjustments is mainly affected by the adjustable accuracy of the four position-controlled clamping cylinders mounted in the upper frames of the segments according to a predetermined transformation relationship between the signals of displacement sensors and aimed roll gap, which, however, is also influenced by the installation accuracy, the precision of displacement sensors, the deformation of the segment frames and/or its bearing pedestals. Due to the actual asynchronous adjustments of the four clamping cylinders, the dynamic soft reduction operation is normally applied at non-ideal mechanical conditions. Here 7 possible situations of asynchronous adjustments of the local segments which may induce gap deviation have been presented. The roll gap deviation in the soft reduction region of a slab casting has been studied by a 3-D visco-elastic plastic FEM model, through which the additional inter-roll bulging, the related triangular cracks induced by one kind of the possible asynchronous adjustment situation and the effectiveness of soft reduction have been analyzed. A critical tolerance for the gap adjustments has been proposed for better contribution of soft reduction to the internal quality of slabs. 展开更多
关键词 slab casting soft reduction clamping cylinder asynchronous adiustment
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MODELING,VALIDATION AND OPTIMAL DESIGN OF THE CLAMPING FORCE CONTROL VALVE USED IN CONTINUOUSLY VARIABLE TRANSMISSION 认领 引用 被引量：4
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作者 ZHOU Yunshan LIU Jin'gang +1 位作者 CAI Yuanchun ZOU Naiwei 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS 2008年第4期51-55,共5页
Associated dynamic performance of the clamping force control valve used in continuously variable transmission(CVT)is optimized.Firstly,the structure and working principle of the valve are analyzed,and then a dynamic m... Associated dynamic performance of the clamping force control valve used in continuously variable transmission(CVT)is optimized.Firstly,the structure and working principle of the valve are analyzed,and then a dynamic model is set up by means of mechanism analysis.For the purpose of checking the validity of the modeling method,a prototype workpiece of the valve is manufactured for comparison test,and its simulation result follows the experimental result quite well.An associated performance index is founded considering the response time,overshoot and saving energy,and five structural parameters are selected to adjust for deriving the optimal associated performance index.The optimization problem is solved by the genetic algorithm(GA)with necessary constraints.Finally,the properties of the optimized valve are compared with those of the prototype workpiece,and the results prove that the dynamic performance indexes of the optimized valve are much better than those of the prototype workpiece. 展开更多
关键词 Dynamic modeling Optimal design Genetic algorithm Clamping force control valve Continuously variable transmission(CVT)
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GREEN QUASIFUNCTION METHOD FOR FREE VIBRATION OF CLAMPED THIN PLATES 认领 引用 被引量：5
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作者 Shanqing Li Hong Yuan 《Acta Mechanica Solida Sinica》 SCIE EI 2012年第1期37-45,共9页
The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This fu... The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This function satisfies the homogeneous boundary condition of the problem.The mode shape differential equation of the free vibration problem of clamped thin plates is reduced to Fredholm integral equation of the second kind by Green formula.Irregularity of the kernel of integral equation is overcome by choosing a suitable form of the normalized boundary equation.Two examples demonstrate the validity of the present method.Comparison with both the series solution and ANSYS finite-element solution shows fine agreement.The present method is a novel and effective mathematical one. 展开更多
关键词 Green function integral equation R-function clamped thin plates free vibration
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NONLINEAR DYNAMICS OF A FGM PLATE WITH TWO CLAMPED OPPOSITE EDGES AND TWO FREE EDGES 认领 引用 被引量：4
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作者 Y.X.Hao W.Zhang J.Yang 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2014年第4期394-406,共13页
This paper deals with the nonlinear forced vibration of FGM rectangular plate with a boundary of two edges clamped opposite and the other two free. The plate is subjected to transversal and in-plane excitations. The p... This paper deals with the nonlinear forced vibration of FGM rectangular plate with a boundary of two edges clamped opposite and the other two free. The plate is subjected to transversal and in-plane excitations. The present research treats the material properties of the FGM plates as temperature-dependent and graded continuously throughout the thickness direction, following the volume fraction of the constituent materials according to the power law. The temperature is assumed to be constant in the plane and varied only in the thickness direction of the plate. In the framework of geometrical nonlinearity the plate is modeled and the equations of motion are obtained on Hamilton＇s principle. With the help of Galerkin discretization, the nonlinear ordinary differential equations describing transverse vibration of the plate are proposed. By the numerical method, the nonlinear dynamical responses of the FGM plate with two clamped opposite and two free edges are analyzed. 展开更多
关键词 functionally graded materials plate clamped bifurcation
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Minimum Normal Force Principle Based Quantitive Optimization of Clamping Forces for Thin Walled Part 认领 引用 被引量：3
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作者 张发平 孙厚芳 SHAHIDI.Butt 《Journal of Beijing Institute of Technology》 EI CAS 2008年第2期148-152,共5页
Based on the stability criteria of workpiece-fixture system, quantitative optimization of clamping forces during precise machining process for thin walled part is studied considering the contact condition between wokp... Based on the stability criteria of workpiece-fixture system, quantitative optimization of clamping forces during precise machining process for thin walled part is studied considering the contact condition between wokpiece and locator, the contact mechanical model is achieved, which is further been used to calculate the entire passive forces acting on the statically undetermined workpiece by means of the force screw theory as well as minimum norm force principle. Furthermore, a new methodology to optimize clamping forces is put forward, on the criteria of keeping the stability of workpiece during cutting process. By this way, the intensity of clamping forces is decreased dramatically, which will be most beneficial for improving the machining quality of thin-walled parts. Finally, a case study is used to support and validate the proposed model. 展开更多
关键词 workpiece-fixture system stability minimum norm force principle clamping forces optimization
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STRENGTH ANALYSIS OF CLAMPING IN MICRO/NANO SCALE EXPERIMENTS 认领 引用 被引量：2
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作者 Liang Liu Dujuan Zeng +2 位作者 Xianlong Wei Qing Chen Xide Li 《Acta Mechanica Solida Sinica》 SCIE EI 2009年第6期584-592,共9页
Two kinds of clamping in microano scale experiments are investigated in this paper, one based on electron-beam-induced deposition, and the other on the van der Waals interaction. The clamping strength and mechanism ar... Two kinds of clamping in microano scale experiments are investigated in this paper, one based on electron-beam-induced deposition, and the other on the van der Waals interaction. The clamping strength and mechanism are analyzed both theoretically and experimentally. The influence of relative humidity on the microano clamping and the method of electrostatic clamping are discussed. The clamping strength and performance of different clamping methods are compared considering the size and material of the clamped objects, and the application environments. 展开更多
关键词 microano experimental mechanics clamping interracial strength electron-beaminduced deposition （EBID） cohesive zone model
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Research and development of a self-centering clamping device for deep-water multifunctional pipeline repair machinery 认领 引用 被引量：2
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作者 Wang Liquan Guo Shiqing +1 位作者 Gong Haixia Shang Xianchao 《Natural Gas Industry B》 2016年第1期82-89,共8页
When multifunctional pipeline repair machinery(MPRM)is used in the deep sea area,it is difficult to grip the pipeline and ensure concentricity between the cutter heads and the pipeline during its operation.In view of ... When multifunctional pipeline repair machinery(MPRM)is used in the deep sea area,it is difficult to grip the pipeline and ensure concentricity between the cutter heads and the pipeline during its operation.In view of this,a new system of two-arm holding self-centering pipeline clamping device was proposed.The system is composed of two groups of parallelogram double-rocker mechanism and cranking block mechanism which are symmetrically distributed on the frame.The geometric parameter solutions of the clamping device were analyzed with motion and transmission as the constraints.A mechanical model was established to associate the friction torque of clamping points with the driving force.Clamping device and machinery were designed and manufactured for theØ304.8e457.2 mm pipelines used in this test.ADAMS simulation experiments were conducted underwater,and the cutting and beveling tests were carried out onshore.The following results are achieved.First,the smaller the pipe diameter,the smaller the transmission angle of the oscillating slider mechanism;the longer the hydraulic cylinder stroke,the greater the transmission angle of the double rocker mechanism.Second,the driving force of the clamping device increases with the increase of the pipe diameter.When the diameter reaches 457.2 mm,the hydraulic cylinder driving force of the clamping device should be greater than 10219 N.Third,the feed rate of the cutters increases suddenly due to the slight shaking of the machinery which occurs at the beginning of the pipe cutting,so it is necessary to adopt a small feed rate.And fourth,onshore experiment results agree well with the theoretical design and simulation results,proving the rationality of the system.The research results in this paper provide technical basis for the research and development of similar engineering prototypes. 展开更多
关键词 Deepwater Submarine pipeline Multifunctional pipeline repair machinery Self-centering Two-arm holding Clamping device ADAMS simulation Experimental study Bevel
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Mechanical Properties of Moso Bamboo Connections with External Clamp Steel Plates 认领 引用 被引量：2
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作者 Shidong Nie Song Ran +3 位作者 Di Wu Jieyu Chen Hui Wang Qike Wei 《Journal of Renewable Materials》 EI CAS 2022年第2期487-510,共24页
The Moso bamboo,a renewable green building material used in various new green buildings,have received exten-sive attention with the promotion of the concept of green buildings.To explore the mechanical properties of M... The Moso bamboo,a renewable green building material used in various new green buildings,have received exten-sive attention with the promotion of the concept of green buildings.To explore the mechanical properties of Moso bamboo connections with external clamp steel plates,the 16 specimens were designed by changing the bolt diameters and the end distances of the bolt holes.Their static tension tests were conducted to investigate bearing capacities and failure modes of different connection configurations.Based on test results,three failure modes of these connections were obtained,including the shear failure of bolt shank,bearing failure of bolt hole and punch-ing shear failure of the Moso bamboo.The influence of bolt diameters and end distances of bolt holes on bearing capacities of the connections was quantitatively analyzed.Based on a simplified mechanical model,the analytical models were deduced for the bolt shear failure and the bearing failure of bolt holes.The results showed that the predictive values are in substantial agreement with the experimental results.Finally,the design and manufacturing suggestions are recommended for this Moso bamboo connections. 展开更多
关键词 Moso bamboo connections external clamp steel plates load-carrying capacities failure modes the 5%d offset method mechanical model
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Proliferating cell nuclear antigen clamp associated factor,a potential proto-oncogene with increased expression in malignant gastrointestinal tumors 认领 引用 被引量：4
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作者 Li-Juan Liu Jian-Ming Liao Fan Zhu 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第10期1425-1439,共15页
Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI cancers.An investi... Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI cancers.An investigation into the potential molecular targets of prediction,diagnosis,prognosis,and therapy in GI cancers is urgently required.Proliferating cell nuclear antigen(PCNA)clamp associated factor(PCLAF),which plays an essential role in cell proliferation,apoptosis,and cell cycle regulation by binding to PCNA,is a potential molecular target of GI cancers as it contributes to a series of malignant properties,including tumorigenesis,epithelial-mesenchymal transition,migration,and invasion.Furthermore,PCLAF is an underlying plasma prediction target in colorectal cancer and liver cancer.In addition to GI cancers,PCLAF is also involved in other types of cancers and autoimmune diseases.Several pivotal pathways,including the Rb/E2F pathway,NF-κB pathway,and p53-p21 cascade,are implicated in PCLAF-mediated diseases.PCLAF also contributes to some diseases through dysregulation of the p53 pathway,WNT signal pathway,MEK/ERK pathway,and PI3K/AKT/mTOR signal cascade.This review mainly describes in detail the role of PCLAF in physiological status and GI cancers.The signaling pathways involved in PCLAF are also summarized.Suppression of the interaction of PCLAF/PCNA or the expression of PCLAF might be potential biological therapeutic strategies for GI cancers. 展开更多
关键词 Proliferating cell nuclear antigen Proliferating cell nuclear antigen clamp associated factor Transcript variant Gastrointestinal cancers Signal pathway Biological therapeutic
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Floating Clamping Mechanism of PT Fuel Injector and Its Dynamic Characteristics Analysis 认领 引用 被引量：1
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作者 WANG Xinqing LIANG Sheng +2 位作者 XIA Tian WANG Dong QIAN Shuhua 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2012年第3期550-556,共7页
PT fuel injector is one of the most important parts of modern diesel engine.To satisfy the requirements of the rapid and accurate test of PT fuel injector,the self-adaptive floating clamping mechanism was developed an... PT fuel injector is one of the most important parts of modern diesel engine.To satisfy the requirements of the rapid and accurate test of PT fuel injector,the self-adaptive floating clamping mechanism was developed and used in the relevant bench.Its dynamic characteristics directly influence the test efficiency and accuracy.However,due to its special structure and complex oil pressure signal,related documents for evaluating dynamic characteristics of this mechanism are lack and some dynamic characteristics of this mechanism can＇t be extracted and recognized effectively by traditional methods.Aiming at the problem above-mentioned,a new method based on Hilbert-Huang transform（HHT） is presented.Firstly,combining with the actual working process,the dynamic liquid pressure signal of the mechanism is acquired.By analyzing the pressure fluctuation during the whole working process in time domain,oil leakage and hydraulic shock in the clamping chamber are discovered.Secondly,owing to the nonlinearity and nonstationarity of pressure signal,empirical mode decomposition is used,and the signal is decomposed and reconstructed into forced vibration,free vibration and noise.By analyzing forced vibration in the time domain,machining error and installation error of cam are revealed.Finally,free vibration component is analyzed in time-frequency domain with HHT,the traits of free vibration in the time-frequency domain are revealed.Compared with traditional methods,Hilbert spectrum has higher time-frequency resolutions and higher credibility.The improved mechanism based on the above analyses can guarantee the test accuracy of injector injection.This new method based on the analyses of the pressure signal and combined with HHT can provide scientific basis for evaluation,design improvement of the mechanism,and give references for dynamic characteristics analysis of the hydraulic system in the interrelated fields. 展开更多
关键词 PT fuel injector floating clamping mechanism dynamic characteristics analysis Hilbert-Huang transform
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Shenfuqiangxin Capsule inhibits apoptosis through mitogen-activated protein kinase signal pathway in rats with cardio-renal syndrome induced by infrarenal aortic-clamping 认领 引用 被引量：3
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作者 Wang Lei Wang Zi +3 位作者 Yuan Ling Hao Di LüNan Li Xu 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2017年第1期80-87,共8页
OBJECTIVE: To investigate the effect of Shenfuqiangxin capsule and the underlying mechanism on cardio-renal syndrome(CRS) in rats induced by infrarenal aortic-clamping after renal ischaemia.METHODS: Male Wistar rats u... OBJECTIVE: To investigate the effect of Shenfuqiangxin capsule and the underlying mechanism on cardio-renal syndrome(CRS) in rats induced by infrarenal aortic-clamping after renal ischaemia.METHODS: Male Wistar rats underwent infrarenal aortic-clamping after renal ischaemia or sham operation. The surviving CRS rats were divided randomly into three groups: CRS group(CRS + 10 m L·kg-1·d-1pure water by gavage), SFQX group(CRS + 13.2 g crude drug·kg- 1·d- 1Shenfuqiangxin by gavage),and handleregionpeptide(HRP)group(CRS+10mg/kg HRP by vein). Sham operation rats were given10 m L·kg-1·d-1pure water. Treatments were given8 weeks after surgery, which lasted for 4 weeks. Therats were detected for heart structure and function by transthoracic echocardiography. PPR m RNA was detected by Reverse Transcription Polymerase Chain Reaction(RT-PCR). To determine whether the mitogen-activated protein kinase(MAPK) signal pathway is included in the heart and kidney protective function of Shenfuqiangxin capsule, MAPK related proteins such as posophorylated C-Jun amino terminal kinase(p-JNK), posophorylated extracellular signal-regulated kinase ?(p-ERK1/2), posophorylated p38(p-p38) were examined by Western Blot.Apoptosis in heart and kidney tissues were detected by d UTP Nick End Labeling staining.RESULTS: Shenfuqiangxin capsule alleviated myocardial apoptosis and inhibited PRR m RNA expression and p-JNK, p-ERK1/2, p-p38 proteins expression in CRS rats.CONCLUSION: All the results suggest that Shenfuqiangxin capsule improves the injured heart and kidney function maybe through inhibition of MAPK response pathway. 展开更多
关键词 Renal ischaemia Cardi-orenal syndrome Shenfuqiangxin capsule Mitogen-activated protein kinases Infrarenal aortic-clamping (Pro) rennin receptor
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