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Research progress of tissue clearing and three-dimensional imaging on multiple effects of acupuncture and moxibustion 认领 引用 被引量：1
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作者 Wen-hao Gao Yu Wang +5 位作者 Xiao-yu Tong Wei Hu Yi-cong Wang Yan Xiao Jia-jia Li Yi Feng 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第1期49-56,共8页
Acupuncture therapy has demonstrated therapeutic effects on various systemic diseases through the use of specific acupoints along meridians.However,due to the multi-target effect of acupuncture and the complexity of m... Acupuncture therapy has demonstrated therapeutic effects on various systemic diseases through the use of specific acupoints along meridians.However,due to the multi-target effect of acupuncture and the complexity of meridian pathways,the underlying mechanisms of acupuncture have not been well understood.Tissue clearing and three-dimensional(3D)imaging is an emerging medical technology that provides high-resolution 3D molecular information while preserving the structural integrity of tissues.In relevant research articles,tissue-clearing and 3D imaging techniques stood out for their ability to visualize the structural characteristics of meridians and acupoints of intact tissues,in order to reveal their intricate connections by means of topological principles.Specifically,this technology has managed to show that acupuncture points like Guilai(ST29)and Sanyinjiao(SP6),which are commonly used in traditional Chinese medicine for treating gynecological disorders,promote angiogenesis in the ovaries and thus improve follicle numbers in polycystic ovary syndrome-like ovaries.This article summarizes recent progress on tissue-clearing and 3D imaging technologies and anticipates the prospects of utilizing this technology to further explore the effects of acupuncture. 展开更多
关键词 Acupuncture Moxibustion Meridian Tissue clearing and 3D imaging Visualization
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Graph-Based Unified Settlement Framework for Complex Electricity Markets:Data Integration and Automated Refund Clearing 认领 引用
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作者 Xiaozhe Guo Suyan Long +4 位作者 Ziyu Yue Yifan Wang Guanting Yin Yuyang Wang Zhaoyuan Wu 《Energy Engineering》 EI 2026年第1期56-90,共35页
The increasing complexity of China’s electricity market creates substantial challenges for settlement automation,data consistency,and operational scalability.Existing provincial settlement systems are fragmented,lack... The increasing complexity of China’s electricity market creates substantial challenges for settlement automation,data consistency,and operational scalability.Existing provincial settlement systems are fragmented,lack a unified data structure,and depend heavily on manual intervention to process high-frequency and retroactive transactions.To address these limitations,a graph-based unified settlement framework is proposed to enhance automation,flexibility,and adaptability in electricity market settlements.A flexible attribute-graph model is employed to represent heterogeneousmulti-market data,enabling standardized integration,rapid querying,and seamless adaptation to evolving business requirements.An extensible operator library is designed to support configurable settlement rules,and a suite of modular tools—including dataset generation,formula configuration,billing templates,and task scheduling—facilitates end-to-end automated settlement processing.A robust refund-clearing mechanism is further incorporated,utilizing sandbox execution,data-version snapshots,dynamic lineage tracing,and real-time changecapture technologies to enable rapid and accurate recalculations under dynamic policy and data revisions.Case studies based on real-world data from regional Chinese markets validate the effectiveness of the proposed approach,demonstrating marked improvements in computational efficiency,system robustness,and automation.Moreover,enhanced settlement accuracy and high temporal granularity improve price-signal fidelity,promote cost-reflective tariffs,and incentivize energy-efficient and demand-responsive behavior among market participants.The method not only supports equitable and transparent market operations but also provides a generalizable,scalable foundation for modern electricity settlement platforms in increasingly complex and dynamic market environments. 展开更多
关键词 Electricity market market settlement data model graph database market refund clearing
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Adaptability Analysis of Dual Clearing Systems in Spot Electricity Markets Based on Fuzzy Evaluation Metrics:An Inner Mongolia Case Study 认领 引用
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作者 Kai Xie Shaoqing Yuan +4 位作者 Dayun Zou Jinran Wang Genjun Chen Ciwei Gao Yinghao Cao 《Energy Engineering》 EI 2026年第2期348-368,共21页
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ... The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty. 展开更多
关键词 Spot electricity markets dual clearing systems fuzzy comprehensive evaluation system adaptability primary-backup switching
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Revolutionizing Tissue Clearing and 3-Dimensional Imaging:Transparent Embedding Solvent System for Uniform High-Resolution Imaging 认领 引用
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作者 Yating Yi Hu Zhao 《Biomedical Engineering Frontiers》 EI CAS 2025年第1期583-587,共5页
Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional(3D)imaging.A newly published transparent embedding system,TESOS(Transparent Embedding Solvent ... Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional(3D)imaging.A newly published transparent embedding system,TESOS(Transparent Embedding Solvent System),ensures consistent submicron resolution imaging throughout the entire sample,and can be compatible with different microscopy systems.This method shows great potential in connectome mapping,and might be an optimal option for future 3D multiplex immunofluorescence and RNA in situ hybridization imaging.Additional efforts would be needed to innovate labeling,imaging,and data processing strategies to fully utilize the potential of transparent embedding systems in highresolution imaging of large-scale samples. 展开更多
关键词 rna situ hybridizat connectome mappingand microscopy systemsthis tissue clearing submicron resolution imaging d multiplex immunofluorescence embedding solvent system ensures transparent embedding
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Glycerophosphodiester phosphodiesterase 1 mediates G3P accumulation for Eureka lemon resistance to citrus yellow vein clearing virus 认领 引用
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作者 Ping Liao Xue Dan +4 位作者 Wen Ge Qi Zhang Jinfa Zhao Changyong Zhou Yan Zhou 《Horticulture Research》 SCIE CSCD 2025年第1期249-260,共12页
Glycerophosphodiester phosphodiesterase 1(GDPD1)plays an important function in the abiotic stress responses and participates in the accumulation of sn-glycerol-3-phosphate(G3P)in plants,which is key to plant systemic ... Glycerophosphodiester phosphodiesterase 1(GDPD1)plays an important function in the abiotic stress responses and participates in the accumulation of sn-glycerol-3-phosphate(G3P)in plants,which is key to plant systemic acquired resistance(SAR).However,the role of GDPD1 in plant responses to biotic stress remains poorly understood.This study characterized the antivirus function of the GDPD1 gene(designated as ClGDPD1)from Eureka lemon.ClGDPD1 is located in the membrane and endoplasmic reticulum,where it interacts with the citrus yellow vein clearing virus(CYVCV)coat protein(CP).Compared to individually expressed ClGDPD1 or coexpressed ClGDPD1+CP140-326,transiently coexpressed ClGDPD1+CP or ClGDPD1+CP1-139 significantly upregulated the key substance contents and genes expression involved in glycerophospholipid metabolism.Over-expression of ClGDPD1 significantly facilitated the accumulation of G3P,upregulated the expression of SAR-related genes,and increased the resistance of transgenic Eureka lemon to CYVCV infection.Furthermore,exogenous glycerol treatment and over-expression of ClGPDH increased the G3P content and reduced CYVCV titers in plants or hairy roots.These results indicated that the enhanced resistance of ClGDPD1 transgenic Eureka lemon to CYVCV may be due to facilitating G3P accumulation through the interaction of ClGDPD1 with CP.Our findings provide novel insights into the role of ClGDPD1 as an important regulatory center in mediating the citrus defense response to viral infections. 展开更多
关键词 citrus yellow vein clearing virus biotic stress glycerophosphodiester phosphodiesterase abiotic stress responses g p accumulation plant systemic acquired resistance sar howeverthe eureka lemon antivirus function
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The evolution and development of railway passenger transportation clearing method in China 认领 引用
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作者 Yin Zhou Wei Fang +2 位作者 Yan Xu Huaixiang Wang Lu Liu 《Railway Sciences》 2025年第1期97-107,共11页
Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency a... Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises.This paper aims to comprehensively and deeply discuss the evolution and development process of China’s railway passenger transport clearing method,analyze its characteristics and influences in each stage,identify the main factors affecting its evolution and development and then put forward thoughts on improving the future development of the clearing method.Design/methodology/approach–Through a detailed review of the railway passenger transport clearing methods from the planned economy period to the reform and opening up period and into the new century,the basis,mode,subject and object of clearing in different development stages are systematically compared.Findings–It comprehensively reveals the evolution of the clearing method,sorted out the characteristics and changes of the clearing method at each stage and the adaptability to the development of railway passenger transport at that time.The characteristics of the development of clearing measures for railway passenger transport in different stages and their far-reaching influence on railway passenger transport business are deeply analyzed.Originality/value–This paper summarized the factors influencing the development of China’s railway passenger transportation clearing approach evolution,including the simplified rules of clearing,enhanced the market adaptability,establishing and perfecting the incentive mechanism,strengthening the construction of informatization,etc.This paper puts forward the ways to improve the railway passenger transportation clearing future development thinking. 展开更多
关键词 Railway transport Railway passenger transport business Carrier system Clearing method Evolution and development
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QUANTITATIVE CONTROL OF OPTICAL CLEARING EFFECTS STUDIED WITH TISSUE-LIKE PHANTOM 认领 引用
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作者 JINGYING JIANG WEI CHEN +1 位作者 QILIANG GONG KEXIN XU 《Journal of Innovative Optical Health Sciences》 SCIE EI 2010年第3期195-202,共8页
Tissue optical clearing by use of optical clearing agents(OCAs)has been proven to have potential to reduce the highly scattering effect of biological tissues in optical techniques.However,the difference in tissue samp... Tissue optical clearing by use of optical clearing agents(OCAs)has been proven to have potential to reduce the highly scattering effect of biological tissues in optical techniques.However,the difference in tissue samples could lead to unreliable results,making it difficult to quantitatively control the dose of OCAs during the course of tissue optical clearing.In this work,in order to study the effects of optical clearing,we customized tissue-like phantoms with optical properties of some biological tissue.Diffuse reflectance and total transmittance of tissue-like phantoms with different OCAs(DMSO or glycerol)and porcine skin tissues were measured.Then optical property parameters were calculated by inverse adding-doubling(IAD)algorithm.Results showed that OCAs could lead to a reduction in scattering of tissue-like phantoms as it did to porcine skin tissue in vitro.Furthermore,a series of relational expressions could be fit to quantitatively describe the relationship between the doses of OCAs and the reduction of scattering effects.Therefore,proper tissue-like phantom could facilitate optical clearing to be used in quantitative control of tissue optical properties,and further promote the application potential of optical clearing to light-based noninvasive diagnostic and therapeutic techniques. 展开更多
关键词 Optical clearing effects tissue-like phantom quantitative control optical properties scattering effects optical clearing agents(OCAs)
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Optical tissue clearing enables rapid,precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research 认领 引用 被引量：7
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作者 Simeon C.Daeschler Jennifer Zhang +1 位作者 Tessa Gordon Gregory H.Borschel 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第6期1348-1356,共9页
Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue sections.Novel optical tissue clearing techniques enabling three-dimensional imaging of entire o... Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue sections.Novel optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the brain.To extend their applicability to experimental nerve repair studies we adapted these techniques to nerves and their motor and sensory targets in rats.The solvent-based protocols rendered harvested peripheral nerves and their target organs transparent within 24 hours while preserving tissue architecture and fluorescence.The optical clearing was compatible with conventional laboratory techniques,including retrograde labeling studies,and computational image segmentation,providing fast and precise cell quantitation.Further,optically cleared organs enabled three-dimensional morphometry at an unprecedented scale including dermatome-wide innervation studies,tracing of intramuscular nerve branches or mapping of neurovascular networks.Given their wide-ranging applicability,rapid processing times,and low costs,tissue clearing techniques are likely to be a key technology for next-generation nerve repair studies.All procedures were approved by the Hospital for Sick Children’s Laboratory Animal Services Committee(49871/9)on November 9,2019. 展开更多
关键词 histology image segmentation morphometry nerve regeneration outcome assessment peripheral nerve three-dimensional imaging tissue clearing
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Monoclonal antibody-based serological detection of Citrus yellow vein clearing virus in citrus groves 认领 引用 被引量：12
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作者 LIU Zhen SUNZHU Yuan-ji +2 位作者 ZHOU Xue-ping HONG Jian WU Jian-xiang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第4期884-891,共8页
Citrus yellow vein clearing virus （CYVCV） is considered as the causal agent of Citrus yellow vein clearing disease and belongs to the genus Mandarivirus in the family Alphaflexiviridae. Capsid protein （CP） of CYVC... Citrus yellow vein clearing virus （CYVCV） is considered as the causal agent of Citrus yellow vein clearing disease and belongs to the genus Mandarivirus in the family Alphaflexiviridae. Capsid protein （CP） of CYVCV Chongqing isolate （CYVCV- CQ） was produced using a prokaryotic expression system and used as the immunogen for monoclonal antibody （MAb） production. Four highly specific and sensitive murine MAbs and one polyclonal antibody were prepared in this study. Titers of the four MAbs in ascites fluids ranged from 10-6 to 10-7 as determined by indirect enzyme-linked immunosorbent assay （ELISA）. Three serological assays, including dot enzyme-linked immunosorbent assay （dot-ELISA）, tissue blot-ELISA, and double-antibody sandwich （DAS）-ELISA, were developed for quick and reliable detections of CYVCV in citrus samples. The developed dot-ELISA and DAS-ELISA methods could detect CYVCV in the infected citrus leaf crude extracts diluted at 1：2 560 and 1：10 240 （w/v, g mL^-1）, respectively. The detection result of 125 citrus leaf samples collected from citrus groves in Yunnan Province and Chongqing Municipality of China showed that approximately 36% samples were positive for CYVCV. This virus was, however, not＇detected in any sample collected from Zhejiang or Jiangxi Province, China. 展开更多
关键词 Citrus yellow vein clearing virus monoclonal antibody serological assay
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Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial 认领 引用 被引量：4
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作者 Wu Zhisong Li Guodong +7 位作者 Wei Wan Liu Zhaoheng Wang Wei Ma Ruihong Liu Wenhong Ma Jiaju Wang Yuguang Jiao Yang 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2018年第5期746-753,共8页
OBJECTIVE: To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold andclearing interio... OBJECTIVE: To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold andclearing interior heat.METHODS: Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were analyzed.RESULTS: Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group(P < 0.05) and the Chinese patent medicine group(P < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group(P <0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group(P <0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 groups.CONCLUSION: The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety. 展开更多
关键词 Releasing exterior cold and clearing interior heat Influenza efficacy Mixture prepared with Chinese medicines
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Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush 认领 引用 被引量：5
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作者 Zong-Yi Zhan Yi-Ru Huang +9 位作者 Lu-Wei Zhao Ya-Dan Quan Zi-Jing Li Di-Fang Sun Ya-Li Wu Hao-Yuan Wu Zi-Tian Liu Kai-Li Wu Yu-Qing Lan Min-Bin Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第4期913-921,共9页
Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve regeneration.However,morphological assessments of retinorecipient regions are... Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve regeneration.However,morphological assessments of retinorecipient regions are limited by the opacity of brain tissue.In this study,we used an innovative tissue cleaning technique combined with retrograde trans-synaptic viral tracing to observe changes in retinorecipient regions connected to retinal ganglion cells in mice after optic nerve injury.Specifically,we performed light-sheet imaging of whole brain tissue after a clearing process.We found that pseudorabies virus 724(PRV724)mostly infected retinal ganglion cells,and that we could use it to retrogradely trace the retinorecipient regions in whole tissue-cleared brains.Unexpectedly,PRV724-traced neurons were more widely distributed compared with data from previous studies.We found that optic nerve injury could selectively modify projections from retinal ganglion cells in the hypothalamic paraventricular nucleus,intergeniculate leaflet,ventral lateral geniculate nucleus,central amygdala,basolateral amygdala,Edinger-Westphal nucleus,and oculomotor nucleus,but not the superior vestibular nucleus,red nucleus,locus coeruleus,gigantocellular reticular nucleus,or facial nerve nucleus.Our findings demonstrate that the tissue clearing technique,combined with retrograde trans-synaptic viral tracing,can be used to objectively and comprehensively evaluate changes in mouse retinorecipient regions that receive projections from retinal ganglion cells after optic nerve injury.Thus,our approach may be useful for future estimations of optic nerve injury and regeneration. 展开更多
关键词 histology image analysis light-sheet imaging optic nerve crush pseudorabies virus retinal ganglion cells three-dimensional imaging tissue clearing viral tracing whole brain study
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Small RNA deep sequencing reveals full-length genome of Citrus yellow vein clearing virus in Chongqing,China 认领 引用 被引量：3
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作者 YU Yun-qi WU Qiong +3 位作者 SU Hua-nan WANG Xue-feng CAO Meng-ji ZHOU Chang-yong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第2期503-508,共6页
To identity the potential pathogen associated with the yellow vein clearing symptom on lemon trees, the profiles of virus-de- rived small interfering RNAs from citrus samples were obtained and analyzed by deep sequenc... To identity the potential pathogen associated with the yellow vein clearing symptom on lemon trees, the profiles of virus-de- rived small interfering RNAs from citrus samples were obtained and analyzed by deep sequencing method in this study. Twenty-seven contigs almost cover the full length genome of Citrus yellow vein clearing virus （CYVCV） isolate YN were obtained using the small RNA deep sequencing technology. Analysis showed that this isolate CQ shared the highest nucleotide identity with isolate Y1 （JX040635） and YN （KP313242）, both of which belong to the genus Mandarivirus in the family Alphaflexiviridae. Mapping analysis of viral-derived siRNA （vsiRNA） profiles revealed an uneven distribution pattern of their generations along both positive and negative genome strands, and 22- and 21-nt vsiRNAs ranked the majority. BLAST against viroids and other viral databases confirmed that this sample was single-infected only by CYVCV, which indicated that CYVCV was the exact causal agent for the yellow clearing symptom occurring on lemon. This is the first CYVCV isolate detected in Chongqing and the second in China. This result could provide a molecular basis for the investigation of citrus viral diseases to protect citrus health in this region. 展开更多
关键词 citrus Citrus yellow vein clearing virus （CYVCV） small RNA deep sequencing
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ASSESSMENT OF OPTICAL CLEARING INDUCED IMPROVEMENT OF LASER SPECKLE CONTRAST IMAGING 认领 引用 被引量：2
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作者 JING WANG DAN ZHU +1 位作者 MIN CHEN XIAOJING LIU 《Journal of Innovative Optical Health Sciences》 SCIE EI 2010年第3期159-167,共9页
Laser Speckle Contrast Imaging(LSCI)plays an important role in studying blood flow,but suffers from limited penetration depth of light in turbid tissue.The strong scattering of tissue obviously reduces the image contr... Laser Speckle Contrast Imaging(LSCI)plays an important role in studying blood flow,but suffers from limited penetration depth of light in turbid tissue.The strong scattering of tissue obviously reduces the image contrast which decreases the sensitivity to flow velocity.Some image processing or optical clearing methods have been proposed to lessen the deficiency,but quantitative assessment of improvement is seldom given.In this study,LSCI was applied to monitor the blood flow through a capillary embedded within various tissue phantoms at depths of 0.25,0.45,0.65,0.85 and 1.05 mm,and the flow velocity in capillary was controllable from 0 to 4mm/s.Here,glycerol,a common optical clearing agent,was mixed with Intralipid at different volume ratio to make the reduced scattering coefficient of tissue phantom decrease from 13.00 to 0.50 cm−1.The quantitative analysis demonstrates that the optical clearing method can obviously enhance the image contrast,imaging depth,and sensitivity to blood flow velocity.Comparing the Laser Speckle Contrast Analysis methods and the optical clearing method,we find that for typical turbid tissue,the sensitivity to velocity estimated by the Laser Speckle Temporal Contrast Analysis(LSTCA)is twice of that by the Laser Speckle Spatial Contrast Analysis(LSSCA);while the sensitivity to velocity estimated by using the two analysis methods has a 10-fold increase,respectively,if addition of glycerol makes the reduced scattering coefficient of tissue phantom decrease by 30%.Combining the LSTCA and the optical clearing method,the sensitivity to flow velocity will be further enhanced. 展开更多
关键词 Glycerol laser speckle contrast imaging the sensitivity to flow velocity estimation optical clearing scattering tissue phantom
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IMPROVE OPTICAL CLEARING OF SKIN IN VITRO WITH PROPYLENE GLYCOL AS A PENETRATION ENHANCER 认领 引用 被引量：2
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作者 ZHONGWEI ZHI ZHENZHEN HAN +1 位作者 QINGMING LUO DAN ZHU 《Journal of Innovative Optical Health Sciences》 SCIE EI 2009年第3期269-278,共10页
In order to enhance the optical clearing effect of topically applied optical clearing agents(OCAs),we evaluated the effect of propylene glycol(PG)as a chemical penetration enhancer(PE)on optical clearing of skin in vi... In order to enhance the optical clearing effect of topically applied optical clearing agents(OCAs),we evaluated the effect of propylene glycol(PG)as a chemical penetration enhancer(PE)on optical clearing of skin in vitro by observation and measurement of optical-transmittance and diffuse-reflectance spectra.Three OCAs,i.e.,glycerol,D-sorbitol and PEG400,and two other penetration enhancers,Azone and Thiazone,were used in this study.The results indicated that the decrease of reduced scattering coefficient caused by OCA/PG was larger than that by pure OCA,and the change by OCA/water was the least after the same treatment time.There were significant differences for the reduced scattering coefficient at 630 nm after 120 min application of agents between OCA and OCA/PG.The efficacy of optical clearing caused by OCA/PG depended on the OCA itself.When PEG400 was mixed with three different PEs,we found the optical clearing were different.The penetration enhancing ability of PG was much better compared to Azone,and suboptimal to Thiazone.Also,this study provides evidence for the use of PG as a PE in order to improve skin optical clearing. 展开更多
关键词 Skin penetration enhancer propylene glycol optical clearing agent.
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Improving sampling depth of laser speckle imaging by topical optical clearing:A theoretical and in vivo study 认领 引用 被引量：2
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作者 D.Li Y.Zhang B.Chen 《Journal of Innovative Optical Health Sciences》 SCIE EI 2020年第2期33-43,共11页
The effect of optical cleaning method combined with laser speckle imaging(LSI)was discussed to improve the detection depth of LSI due to high scattering characteristics of skin,which limit its clinical application.A d... The effect of optical cleaning method combined with laser speckle imaging(LSI)was discussed to improve the detection depth of LSI due to high scattering characteristics of skin,which limit its clinical application.A double-layer skin tissue model embedded with a single blood vessel was established,and the Monte Carlo method was used to simulate photon propagation under the action of light-permeating agent.808 nm semiconductor and 632.8 nm He–Ne lasers were selected to study the e®ect of optical clearing agents(OCAs)on photon deposition in tissues.Results show that the photon energy deposition density in the epidermis increases with the amount of tissue°uid replaced by OCA.Compared with glucose solution,polyethylene glycol 400(PEG 400)and glycerol can considerably increase the average penetration depth of photons in the skin tissue,thereby raising the sampling depth of the LSI.After the action of glycerol,PEG 400,and glucose,the average photon penetration depth is increased by 51.78%,51.06%,and 21.51%for 808nm,68.93%,67.94%,and 26.67%for 632.8 nm lasers,respectively.In vivo experiment by dorsal skin chamber proves that glycerol can cause a substantial decrease in blood°ow rate,whereas PEG 400 can signicantly improve the capability of light penetration without a®ecting blood velocity,which exhibits considerable potential in the monitoring of blood°ow in skin tissues. 展开更多
关键词 Laser speckle image topical optical clearing imaging depth Monte-Carlo simulation dorsal skin experiment
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Combining CUBIC Optical Clearing and Thy1-YFP-16 Mice to Observe Morphological Axon Changes During Wallerian Degeneration 认领 引用 被引量：1
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作者 Yu-song YUAN Fei YU +3 位作者 Su-ping NIU Hao LU Yu-hui KOU Hai-lin XU 《Current Medical Science》 SCIE CAS 2021年第5期944-952,共9页
Objective:Wallerian degeneration is a pathological process closely related to peripheral nerve regeneration following injury,and includes the disintegration and phagocytosis of peripheral nervous system cells.Traditio... Objective:Wallerian degeneration is a pathological process closely related to peripheral nerve regeneration following injury,and includes the disintegration and phagocytosis of peripheral nervous system cells.Traditionally,morphological changes are observed by performing immunofluorescence staining after sectioning,which results in the loss of some histological information.The purpose of this study was to explore a new,nondestmetive,and systematic method for observing axonal histological changes during Wallerian degeneration.Methods:Thirty male Thy1-YFP-16 mice(SPF grade,6 weeks old,20±5 g)were randomly selected and divided into clear,unobstructed brain imaging cocktails and computational analysis(CUBIC)optical clearing(n=15)and traditional method groups(n=15).Five mice in each group were sacrificed at 1st,3rd,and 5th day following a crush operation.The histological axon changes were observed by CUBIC light optical clearing treatment,direct tissue section imaging,and HE staining.Results:The results revealed that,compared with traditional imaging methods,there was no physical damage to the samples,which allowed for three-dimensional and deep-seated tissue imaging through CUBIC.Local image information could be nicely obtained by direct fluorescence imaging and HE staining,but it was difficult to obtain image information of the entire sample.At the same time,the image information obtained by fluorescence imaging and HE staining was partially lost.Conclusion:The combining of CUBIC and Thy1-YFP transgenic mice allowed for a clear and comprehensive observation of histological changes of axons in Wallerian degeneration. 展开更多
关键词 Wallerian degeneration axon optical clearing clear,unobstructed brain imaging cocktails and computational analysis Thy1-YFP transgenic mice
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Efficacy and safety of a sequential treatment with clearing heat and eliminating phlegm and tonifying Qi and activating blood circulation in treating acute ischemic stroke:study protocol for a randomized controlled trial 认领 引用 被引量：1
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作者 ZHOU Ziyi WAN Can +16 位作者 ZHAO Yuanqi LIU Xiangzhe GAO Ying AN Hongwei LI Lejun ZHANG Huili YU Xiaofei ZHANG Xinchun WANG Huijuan SHI Qing WEI Chunhua CHEN Jie HUANG Wenguo CHEN Junbin GAO Ying HU Mingzhe CAI Yefeng 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2022年第4期604-610,共7页
OBJECTIVE:To investigate the short-term efficacy and safety outcomes following a sequential treatment with clearing heat and eliminating phlegm(CHEP)formula and tonifying Qi and activating blood circulation(TQABC)form... OBJECTIVE:To investigate the short-term efficacy and safety outcomes following a sequential treatment with clearing heat and eliminating phlegm(CHEP)formula and tonifying Qi and activating blood circulation(TQABC)formula in patients with acute ischemic stroke(AIS)within a 72 h time window.METHODS:In this randomized,multicenter,doubleblinded,placebo-controlled trial,500 participants will be randomly assigned in a ratio of 1∶1 to the CHEP+TQABC group or control group.In addition to guidelinebased standard medical care,participants in the treatment group will receive the CHEP formula for the first 5 consecutive days followed by the TQABC formula for another 10 consecutive days,while those in the control group will receive CHEP formula placebo and TQABC formula placebo consecutively.The primary outcome measure will be the comparison of the change in the National Institutes of Health Stroke Scale score from baseline to 15 days after randomization.The secondary outcome measures will include the scores on the modified Rankin Scale,Barthel Index,Patient-Reported Outcomes,TCM symptom pattern(Zheng-hou)evaluation Scale,and the incidence of in-hospital complications.Safety assessment will include the physical examination,laboratory detection,any adverse events or serious adverse events,and the proportion of any complications during hospitalization.DISCUSSION:The results of this study will provide objective and scientific data with which to assess the efficacy and safety of a sequential treatment based on“integrating disease and symptom pattern”for patients with AIS. 展开更多
关键词 stroke clearing heat and eliminating phlegm tonifying Qi and activating blood circulation randomized controlled trial clinical protocols
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Tissue Optical Clearing Imaging from Ex vivo toward In vivo 认领 引用 被引量：3
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作者 Dan Zhu Valery V.Tuchin 《Biomedical Engineering Frontiers》 CAS 2024年第1期151-154,共4页
Organisms are composed of a vast number of highly specialized cells with characteristic physiological functions determined by their structure.Therefore,understanding physiological and pathological mechanisms requires ... Organisms are composed of a vast number of highly specialized cells with characteristic physiological functions determined by their structure.Therefore,understanding physiological and pathological mechanisms requires obtaining 3-dimensional(3D)structural information at the cellular level across tissues,organs,and even the whole body.However,the scattering and absorption of tissue limits the penetration depth of light and thus extremely reduces the imaging performance in deep tissue.It is well known that 3D imaging outperforms 2D imaging in various scenarios for 3D reconstruction of tissue structures.This includes tracing convoluted 3D structures like vasculature,neurons,and prostate glands,as well as elucidating intricate distributions of cells or lesions. 展开更多
关键词 imaging ex vivo vivo physiological pathological mechanisms tissue optical clearing dimensional structural information deep tissueit cellular level
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CLINICAL STUDY ON ACUPUNCTURE IN THE TREATMENT OF POST-STROKE DEPRESSION WITH THE METHOD OF ACTIVATING THE DU MERIDIAN AND CLEARING THE MIND 认领 引用 被引量：1
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作者 何希俊 赖新生 +1 位作者 谭吉林 王本国 《World Journal of Acupuncture-Moxibustion》 CAS 2006年第3期8-12,27,共5页
Objective: To observe the therapeutic effect of acupuncture in the treatment of post-stroke depression (PSD) with the method of activating the Du Meridian and clearing the mind. Methods: Two hundred and thirty one cas... Objective: To observe the therapeutic effect of acupuncture in the treatment of post-stroke depression (PSD) with the method of activating the Du Meridian and clearing the mind. Methods: Two hundred and thirty one cases of PSD were randomly divided into two groups, acupuncture and control groups. In acupuncture group, Baihui (百会 GV 20), Dazhui (大椎 GV 14), Neiguan (内关 PC 6), Taichong (太冲 LR 3) and Shenmen (神门 HT 7) were selected as the main points to invigorate flow of qi in the Du Meridian and clear the mind. Patients in the control group received Fluoxetine orally, 20 mg once per-day. In addition, the same routine treatments were given to both groups, strengthened with rehabilitation exercises as early as possible; 8 weeks constituted one therapeutic course. HAMD and severity of neuro-functional defect of each case were evaluated before and 8-week after the treatment. Results: The total effective rate of acupuncture group was 92.37%, the control group, 72.88%. According to χ2 test, the difference between the two groups was remarkably significant (P<0.05). Conclusion: Acupuncture therapy of activating the Du Meridian and clearing the mind in the treatment of PSD was safe and effective. 展开更多
关键词 Post-stroke depression Acupuncture therapy Fluoxetine Acupuncture therapy of activating the Du Meridian and clearing the mind
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PARAMETRIC STUDY OF TISSUE OPTICAL CLEARING BY LOCALIZED MECHANICAL COMPRESSION USING COMBINED FINITE ELEMENT AND MONTE CARLO SIMULATION 认领 引用 被引量：1
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作者 WILLIAM C.VOGT HAIOU SHEN +1 位作者 GE WANG CHRISTOPHER G.RYLANDER 《Journal of Innovative Optical Health Sciences》 SCIE EI 2010年第3期203-211,共9页
Tissue Optical Clearing Devices(TOCDs)have been shown to increase light transmission through mechanically compressed regions of naturally turbid biological tissues.We hypothesize that zones of high compressive strain ... Tissue Optical Clearing Devices(TOCDs)have been shown to increase light transmission through mechanically compressed regions of naturally turbid biological tissues.We hypothesize that zones of high compressive strain induced by TOCD pins produce localized water displacement and reversible changes in tissue optical properties.In this paper,we demonstrate a novel combined mechanical finite element model and optical Monte Carlo model which simulates TOCD pin compression of an ex vivo porcine skin sample and modified spatial photon fluence distributions within the tissue.Results of this simulation qualitatively suggest that light transmission through the skin can be significantly affected by changes in compressed tissue geometry as well as concurrent changes in tissue optical properties.The development of a comprehensive multi-domain model of TOCD application to tissues such as skin could ultimately be used as a framework for optimizing future design of TOCDs. 展开更多
关键词 Finite element Monte Carlo optical clearing porcine skin tissue compression
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