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Dietary supplementation with sodium isobutyrate enhances growth performance and colonic barrier function in weaned piglets via microbiota-metabolite-host interactions 认领 引用 被引量：1
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作者 Xiuyu Fang Zihan Chi +6 位作者 Zhengyi Wang Xinlin Wang Xingrui Qu Shuang Zhang Feng Gao Baoming Shi Xuan Zhao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期404-425,共22页
Background Weaning-induced diarrhoea and growth retardation in piglets are associated with impaired intestinal barrier function and decreased levels of colonic short-chain fatty acids(SCFAs).Although SCFA supplementat... Background Weaning-induced diarrhoea and growth retardation in piglets are associated with impaired intestinal barrier function and decreased levels of colonic short-chain fatty acids(SCFAs).Although SCFA supplementation has been proposed to mitigate these issues,the efficacy and optimal dosage of sodium isobutyrate remain unclear.Results We investigated the effects of sodium isobutyrate supplementation(500,1,000,2,000,and 4,000 mg/kg diet)on weaned piglets(Duroc×Landrace×Yorkshire,28 d of age;n=8).After a 28-d feeding trial,supplementation at 500–2,000 mg/kg significantly improved average daily gain and feed efficiency and reduced diarrhoea frequency,with maximal benefits observed at 1,000 mg/kg(P<0.0001).Additionally,500–1,000 mg/kg sodium isobutyrate supplementation increased the apparent digestibility of crude protein,organic matter,and crude fibre(P<0.05).Serum biochemical parameters were unaffected,although secretory immunoglobulin A(SIgA)levels significantly increased upon supplementation with 500–1,000 mg/kg(P<0.05).16S rRNA gene sequencing indicated that sodium isobutyrate increased the abundance of beneficial colonic microbiota.The 1,000 mg/kg group presented the most pronounced effect,with a significant increase of the relative abundance of Prevotella and the greatest improvement in SCFA concentrations(P<0.05).Metabolomics revealed elevated levels of colonic indole-3-lactic acid and 3-hydroxybutyrate upon supplementation with 1,000 mg/kg(P<0.05).Transcriptomic analyses indicated activation of protein digestion and absorption pathways,and PI3K-Akt signalling,marked by TSG-6 upregulation and the suppression of ISG15 and DDIT4 expression(P<0.05).Supplementation with 1,000 mg/kg was associated with improved intestinal barrier-related markers,including reduced serum D-lactate,diamine oxidase,and lipopolysaccharide levels,increased tight junction protein expression;activation of G protein-coupled receptors;and inhibition of TLR4/MyD88/NF-κB signalling(P<0.05),suggesting enhanced barrier function.Conclusions In conclusion,dietary supplementation with 1,000 mg/kg sodium isobutyrate was associated with improved intestinal morphology,reduced serum permeability,increased expression of tight junction proteins,and enhanced immune function in weaned piglets,suggesting enhanced colonic barrier function and providing dosage guidance and mechanistic insights for future applications. 展开更多
关键词 Colonic barrier function Diarrhoea Intestinal microbiota Sodium isobutyrate Weaned piglets
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Colonic diverticular hemorrhage:Etiology,diagnostic challenges,and evolving therapeutic strategies 认领 引用 被引量：1
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作者 Yi-Qing Hui Zhi-Xuan Wang +1 位作者 Chun-Xi Wang Chuan Tong 《World Journal of Gastroenterology》 SCIE CAS 2026年第4期8-17,共10页
Colonic diverticular hemorrhage is a major cause of acute lower gastrointestinal bleeding,particularly in aging populations with increasing prevalence of diverticulosis.Its pathogenesis is multifactorial,involving vas... Colonic diverticular hemorrhage is a major cause of acute lower gastrointestinal bleeding,particularly in aging populations with increasing prevalence of diverticulosis.Its pathogenesis is multifactorial,involving vascular fragility of the vasa recta,mechanical stress,and patient-related factors such as comorbidities and use of antithrombotic agents.Diagnosis remains challenging due to the intermittent nature of bleeding,with colonoscopy serving as the primary tool and computed tomography angiography providing complementary value for source localization.Endoscopic therapy,especially band ligation,has demonstrated superiority over clipping in reducing rebleeding,while transcatheter arterial embolization has emerged as an effective salvage approach when endoscopic treatment fails.Surgical intervention is reserved for refractory or complicated cases.Recent advances include risk stratification models to guide management and early feeding strategies to accelerate recovery.Despite these improvements,challenges remain in recurrence prevention and individualized treatment selection.This editorial synthesizes current evidence on the etiology,diagnostic modalities,and evolving therapeutic strategies of colonic diverticular hemorrhage,aiming to support clinical decision-making and optimize patient outcomes. 展开更多
关键词 Colonic diverticular hemorrhage Etiology Diagnostic techniques Endoscopic therapy Interventional embolization Surgical treatment
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Anastomotic colonic varices after colectomy treated by obliteration via a transhepatic portal approach:A case report 认领 引用
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作者 Daisuke Tomita Masayoshi Yamamoto +8 位作者 Masato Wakamatsu Ryo Shibayama Yusuke Maeda Kosuke Hiramatsu Yutaka Hanaoka Shigeo Toda Masashi Ueno Shuichiro Matoba Hiroya Kuroyanagi 《World Journal of Gastroenterology》 SCIE CAS 2026年第18期109-117,共9页
BACKGROUND Colonic anastomotic varices are extremely rare,particularly in patients without portal hypertension.Their clinical presentation is often nonspecific,and standardized diagnostic and therapeutic strategies ha... BACKGROUND Colonic anastomotic varices are extremely rare,particularly in patients without portal hypertension.Their clinical presentation is often nonspecific,and standardized diagnostic and therapeutic strategies have not yet been established.We report a unique case of recurrent lower gastrointestinal bleeding from transverse colonic anastomotic varices in a noncirrhotic patient who was successfully treated with percutaneous embolization.CASE SUMMARY A 65-year-old man with a history of laparoscopic transverse colectomy presented with recurrent melena at 30-,35-,and 38-month postoperatively.Colonoscopy repeatedly demonstrated active bleeding from dilated submucosal veins at the anastomotic site,and endoscopic clipping provided only temporary hemostasis.Laboratory tests revealed preserved hepatic function,and imaging revealed no findings suggestive of portal hypertension.Due to refractory bleeding and the invasive nature of the reoperation,an interventional radiology(IR)approach was selected.Computed tomography portography revealed venous convergence in both the superior and inferior mesenteric systems at the anastomotic site.Targeted embolization via the transhepatic portal approach successfully achieved complete obliteration of varices.The patient did not experience further bleeding during the months of follow-up.CONCLUSION IR is an effective and minimally invasive treatment option for refractory anastomotic colonic varices in patients without portal hypertension. 展开更多
关键词 Anastomotic varices Colonic varices Lower gastrointestinal bleeding Normal portal pressure Interventional radiology Transhepatic portal approach Computed tomography portography Variceal obliteration Case report
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Case report:minimally invasive management of two major complications of colonic perforation and pseudoaneurysm formation following nephrostomy tube placement 认领 引用
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作者 Marie-Lou Letouche Aideen Madden +2 位作者 Mariela Corralles Steeve Doizi Olivier Traxer 《The Canadian Journal of Urology》 SCIE 2026年第1期227-232,共6页
Background:We present a case of two major complications following insertion of a nephrostomy managed in a minimally invasive way.Our case is the first in the literature to describe this minimally invasive treatment te... Background:We present a case of two major complications following insertion of a nephrostomy managed in a minimally invasive way.Our case is the first in the literature to describe this minimally invasive treatment technique for colon perforation in a completely asymptomatic patient.Case Description:A 75-year-old female patient with a history of bilateral obstructive uropathy secondary to bilateral radiation-induced ureteric strictures attended for bilateral nephrostomy placement.The patient had a history of endometrial cancer,treated previously by total hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemo-radiotherapy and brachytherapy.Her recovery had been further complicated by the development of radiation cystitis,small bowel resection,and short gut syndrome.The strictures had previously been managed with bilateral double J stents,which have now failed.A left-sided nephrostomy insertion was performed.ACT-scan prompted by a repeat deterioration in renal function revealed a right-sided hydronephrosis and suggested transcolic passage of the previously placed leftsided nephrostomy.She had remained clinically well and apyretic.A right-sided nephrostomy was inserted,and the left re-sited following a colonoscopy-guided nephrostomy removal and clip occlusion of the nephrostomy tract.The patient then developed a pseudoaneurysm,which was managed with embolization.The patient was able to return home with corrected kidney function.The three-monthly checks for changes in nephrostomy catheters did not reveal any complications.Conclusions:The patient therefore presented with two major complications of nephrostomy placement:colonic perforation and pseudoaneurysm,classified as Clavien IIIb and IIIa,respectively.Multidisciplinary management,including urologists,gastroenterologists,general surgeons,and radiologists,enabled a minimally invasive management.Minimally invasive management with endoscopic clip placement appears to be a safe alternative to directed fistula of colonic perforation. 展开更多
关键词 nephrostomy colonic injuries conservative treatment pseudoaneurysm embolization
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Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion:A case report 认领 引用
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作者 Chong-Wei Yang Ri-Xin Zhang +3 位作者 Xiao-Lin Zheng Ling Zhu Zhi Zheng Xin-Hua Wu 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第7期372-379,共8页
BACKGROUND Spontaneous rupture is a life-threatening complication of liver cancer.Cases involving direct tumor invasion of adjacent organs,such as the colon,pose major management challenges and are associated with ext... BACKGROUND Spontaneous rupture is a life-threatening complication of liver cancer.Cases involving direct tumor invasion of adjacent organs,such as the colon,pose major management challenges and are associated with extremely poor prognoses.This report describes a successful multidisciplinary approach to such a rare clinical scenario.CASE SUMMARY We present the case of a 69-year-old man with a giant ruptured liver cancer in the right lobe with direct colonic invasion.The patient was initially stabilized with transarterial embolization.After multidisciplinary discussion and preoperative optimization,he successfully underwent en bloc right hepatectomy combined with right colectomy,cholecystectomy,and intraoperative peritoneal chemotherapy on post-rupture day 19(the fifth day after admission to our institution).The postoperative course was uneventful.Pathological examination confirmed a combined hepatocellular cholangiocarcinoma with focal invasion into the colonic subserosa.Subsequently,the patient received adjuvant therapy consisting of transarterial chemoembolization,lenvatinib,and tislelizumab for occult intrahepatic micrometastases detected 1.5 months postoperatively.During 42 months of follow-up,the patient’s tumor markers normalized,and surveillance imaging showed no evidence of tumor activity.CONCLUSION Aggressive surgical resection combined with multimodal adjuvant therapy may achieve favorable long-term survival in patients with ruptured liver cancer with colonic invasion. 展开更多
关键词 Combined hepatocellular cholangiocarcinoma Liver cancer rupture Colonic invasion Combined resection Multimodal adjuvant therapy Hepatocellular carcinoma Case report
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Butyrate combined with niacin enhances intestinal barrier function repair in weaned piglets infected with ETEC by promoting colonic metabolism and antimicrobial peptide expression 认领 引用
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作者 Qingsong Tang Rui Zhen +9 位作者 Bijing Yang Zhenyan Miao Yangyang Wei Shihui Ruan Yiyi He Yunxia Xiong Qiwen Wu Li Wang Zongyong Jiang Hongbo Yi 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第4期2273-2292,共20页
Background Weaning piglets are highly susceptible to enterotoxigenic Escherichia coli(ETEC)infections,which can cause intestinal barrier function dysfunction and death.However,there is still a lack of efficient,econom... Background Weaning piglets are highly susceptible to enterotoxigenic Escherichia coli(ETEC)infections,which can cause intestinal barrier function dysfunction and death.However,there is still a lack of efficient,economical,and safe nutritional interventions.This study aimed to investigate the effects of combining butyrate with niacin on intestinal barrier function repair and resistance to ETEC infection in weaned piglets.In this study,two 14-d animal experiments were designed to observe the optimal butyrate-to-niacin ratio and assess their responses to the ETEC challenge.Results Supplementation with butyrate and niacin at a ratio of 100:2(2,000 mg/kg butyrate and 40 mg/kg niacin,BN2)increased the average daily gain(ADG)and reduced the diarrhea incidence.We also observed an increase in the levels of nicotinamide adenine dinucleotide(NAD)in the colon of weaned piglets.Notably,BN2 promoted amino acid anabolism in the colon and enhanced glycolysis and the tricarboxylic acid(TCA)cycle by increasing the acetylation of key enzymes in the TCA.Furthermore,BN2 enhanced the expression of indispensable genes for the colonic mucosal barrier,including antimicrobial peptides such as porcineβdefensin 1(pBD1),porcineβdefensin 2(pBD2),and proline-arginine rich 39-amino acid peptide(PR39),tight junction proteins,and improved colonic microbiome composition.Based on these findings,we found that BN2 alleviated growth restriction and diarrhea,and modulated the expression of antimicrobial peptides,tight junction proteins,and cytokines to reduce colonic barrier function dysfunction in weaned piglets challenged with ETEC.Mechanistically,we confirmed that BN2elevated the protein expression of acetylation of histone 3 lysin 27(H3K27ac)and enhanced the binding of acH3K27to the promoter regions of pBD1 and PR39.Conclusions Supplementation with BN2 improved growth performance,supported colonic barrier function repair,and enhanced disease resistance in weaned piglets challenged with ETEC.This offers new insights into nutritional strategies for intestinal barrier function repair of piglets infected with ETEC. 展开更多
关键词 Butyrate Colonic barrier function Enterotoxigenic Escherichia coli Niacin Weaned piglets
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Risk factor analysis and nomogram model construction for mortality in patients following colonic perforation surgery 认领 引用
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作者 Xiu-Juan Xu Hou-Dao Zhang +2 位作者 Chu-Ji Cheng Ya-Ming Zhang Qi Zhang 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第2期105-116,共12页
BACKGROUND Colonic perforation is a surgical emergency with high mortality due to rapid progression to septic shock.Early identification of high-risk patients is critical for improving outcomes,yet existing predictive... BACKGROUND Colonic perforation is a surgical emergency with high mortality due to rapid progression to septic shock.Early identification of high-risk patients is critical for improving outcomes,yet existing predictive tools are often complex and lack clinical practicality.AIM To identify the risk factors for postoperative mortality in patients with colonic perforation and develop and validate a predictive model.METHODS A retrospective analysis was conducted on patients who underwent surgery for colonic perforation at the Department of Critical Medicine and General Surgery,Anqing Municipal Hospital,between January 2020 and July 2025.Patients were selected on the basis of inclusion and exclusion criteria and were classified into two groups according to postoperative outcomes:Death and survival.General demographics,laboratory results,and imaging data were collected and compared between the two groups.Univariate analysis was performed initially,followed by multivariate logistic regression analysis for variables with significant differences in the univariate analysis.A predictive model for postoperative mortality was constructed on the basis of the multivariate results.Internal validation was conducted using the bootstrap resampling method.The clinical optimal threshold was identified through decision curve analysis(DCA),and the operability of the dual cut-off strategy was demonstrated using a full-sample confusion matrix and a funnel-type pathway diagram.A nomogram was developed as a personalized prediction tool.RESULTS A total of 134 patients were included in the study,with 21 patients in the postoperative death group and 113 in the survival group,yielding a mortality rate of 15.6%.Moreover,no significant differences were found between the two groups concerning sex,history of hypertension,diabetes,cerebrovascular sequelae,cardiac history,haemoglobin level,albumin concentration,intraperitoneal free gas presence,intraperitoneal free fluid presence,perforation site,cause of perforation,operation time,or intraoperative blood loss volume.However,significant differences in age;American Society of Anaesthesiologists classification;Acute Physiology and Chronic Health Evaluation II(APACHE II)score;preoperative peripheral blood white blood cell(WBC)count;platelet count;serum total bilirubin level;serum creatinine level;lactate level;C-reactive protein level;procalcitonin level;the presence of portal venous gas(PVG);and time from onset to surgery(whether>24 hours)were detected(all P<0.05).Multivariate logistic regression analysis revealed that the APACHE II score[odds ratio(OR)=1.24,95%confidence interval(CI):1.03-1.48],lactate level(OR=2.40,95%CI:1.34-4.31),and presence of PVG(OR=20.32,95%CI:1.89-218.45)were risk factors for postoperative mortality,whereas an elevated WBC count(OR=0.68,95%CI:0.55-0.85)served as a protective factor.The constructed receiver operating characteristic curve revealed an area under the curve of 0.852(95%CI:0.791-0.913),with a Brier score=0.072 and a slope≈1.DCA demonstrated that within the 1%-40%threshold interval,the net benefit of the three model cut-off points surpassed those of the“full intervention”and“no intervention”scenarios.The full-sample pathway validation showed that the funneltype process achieved 95.2%sensitivity for mortality screening with a 53%relative reduction in intensive care unit admissions.CONCLUSION The predictive model for postoperative mortality in patients with colonic perforation,which is based on four indicators(APACHE II score,lactate level,WBC count,and PVG presence),demonstrates strong predictive performance.The dual cut-off pathway(0.020 high-sensitivity screen+0.121 resource-efficient confirmation)markedly reduced intensive care unit resource use while maintaining high sensitivity(95.2%).This investigation offers a replicable decision-making tool that can be integrated into information systems for future prospective studies. 展开更多
关键词 Colonic perforation Mortality Nomogram Risk factors Septic shock
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Unlocking the colon clock:Bridging the gap in colonic transit time studies for optimal management of chronic constipation 认领 引用
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作者 Shivam Kalra Manjeet Kumar Goyal +3 位作者 Kartikay Goyal Rajdeep Singh Ashita Rukmini Vuthaluru Omesh Goyal 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2026年第1期71-81,共11页
Functional constipation affects up to 15%of the global population,significantly affecting the quality of life and imposing substantial clinical and economic burdens.Colonic transit time(CTT)studies have emerged as a p... Functional constipation affects up to 15%of the global population,significantly affecting the quality of life and imposing substantial clinical and economic burdens.Colonic transit time(CTT)studies have emerged as a pivotal diagnostic tool for distinguishing various types of functional constipation(i.e.,slow transit constipation,normal transit constipation,and ano-rectal dyssynergia),thereby guiding personalized treatment strategies and enabling precise monitoring of therapeutic response.CTT studies using radiopaque markers(ROM)have been the most widely used technique by researchers worldwide.Despite its affordability and high diagnostic yield,the ROM CTT study remains grossly underutilized in routine clinical practice largely due to a pervasive lack of awareness among physicians regarding its methodological nuances and clinical advantages.This narrative review systematically examined the multifaceted role of ROM CTT studies in clinical practice.It underscored how ethnic,dietary,and lifestyle factors profoundly influence colonic motility,thereby necessitating the development of populationspecific diagnostic protocols.The review also highlighted the significant variability in imaging methodologies,such as differences in radiographic timing and patient positioning(supine vs erect),which further complicate the interpretation and reliability of CTT assessments.By drawing on a wide spectrum of research,this review advocated for enhanced physician education and the implementation of standardized,evidence-based protocols.Such initiatives are critical to optimizing the diagnostic accuracy and clinical utility of ROM CTT studies,ultimately leading to more effective management of refractory constipation and improved patient outcomes. 展开更多
关键词 Constipation Gastrointestinal motility Colonic transit time Abdominal radiography Diagnostic techniques Digestive system Ethnic groups Health care disparities
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SGFNet:An Attention-Enhanced Network for Colonic Polyp Segmentation in Endoscopic Images 认领 引用
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作者 PANG Bo LIU Guohua 《Journal of Donghua University(English Edition)》 CAS 2026年第3期101-112,共12页
Accurate segmentation of colonic polyps in endoscopic images is vital for early diagnosis and prevention of colorectal cancer(CRC).However,this task remains challenging due to the high variability in polyp morphology,... Accurate segmentation of colonic polyps in endoscopic images is vital for early diagnosis and prevention of colorectal cancer(CRC).However,this task remains challenging due to the high variability in polyp morphology,low contrast with surrounding mucosa,and frequent boundary ambiguity.To address these issues,we propose a selective-gated fusion network(SGFNet),a lightweight semantic segmentation network based on the U-Net architecture.SGFNet incorporates two targeted modules:the SSE-Encoder,which integrates selective kernel convolution(SKConv)and squeeze-and-excitation(SE)attention to enhance multi-scale representation and channel recalibration;the PGF-Unit,which employs a gated parallel polarized self-attention(PPSA)mechanism to improve boundary-sensitive feature fusion.The model is evaluated on a unified dataset of 1612 annotated images from Kvasir-SEG and CVC-ClinicDB.Experimental results demonstrate that SGFNet achieves superior performance in mean intersection over union(mIoU),pixel accuracy(PA),and F1 score,outperforming several representative baseline models.With its balanced design and strong generalization,SGFNet offers a practical and interpretable solution for realworld medical image segmentation and provides insights into attention-based module integration for future computeraided diagnosis systems. 展开更多
关键词 colonic polyp segmentation U-Net multi-scale feature encoding attention mechanism SGFNet medical image analysis
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T-cell lymphoblastic lymphoma with colonic involvement:A case report 认领 引用
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作者 Abeer Qasim George Sarin Zacharia +3 位作者 Sameer D Kandhi Priscilla Hallal Lajara Rayan Faisal Grib Alataa Ariyo Ihimoyan 《World Journal of Clinical Cases》 2026年第17期69-75,共7页
BACKGROUND The gastrointestinal(GI)tract is the most common extranodal site for non-Hodgkin lymphoma.Most GI lymphomas originate from B-cell lineages;T-cell lymphomas are notably rare.Colonic involvement by lymphoma,u... BACKGROUND The gastrointestinal(GI)tract is the most common extranodal site for non-Hodgkin lymphoma.Most GI lymphomas originate from B-cell lineages;T-cell lymphomas are notably rare.Colonic involvement by lymphoma,unlike that of the stomach and small intestine,is particularly uncommon.Patients often present with nonspecific symptoms,including pain,diarrhea,weight loss,or bleeding.At endoscopy,these tumors appear as irregular ulcers,nodular or fungating masses,or polypoid lesions;diagnosis require histopathology and immunochemical staining.CASE SUMMARY This report presents an apparently asymptomatic 66-year-old man who was incidentally found to have generalized lymphadenopathy on physical examination and nodular colonic lesions during colonoscopy.Cross-sectional imaging demonstrated extensive,confluent lymphadenopathy involving the retroperitoneal,bilateral iliac,inguinal,mesenteric,pelvic,and cervical nodes,concerning for a lymphoproliferative disorder.Both nodal and extranodal lesions exhibited histologically and immunologically similar T lymphoblasts,consistent with T-cell lymphoblastic lymphoma,Ann Arbor stage IV.CONCLUSION This case illustrates an exceptionally rare presentation of T-lymphoblastic lymphoma as colonic polypoid lesions,emphasizing the need to consider hematologic malignancies in the differential diagnosis of colorectal polyps.Early recognition,thorough histopathologic evaluation,and comprehensive staging are critical for management,given the aggressive nature and poor prognosis of these neoplasia. 展开更多
关键词 T-cell lymphoblastic lymphoma Colon Polyp Colonoscopy Gastrointestinal Case report
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Outcomes of colonic stent as a bridge to surgery vs emergency surgery for acute obstructive left-sided colon cancer 认领 引用 被引量：1
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作者 Hui Xiao Hua-Chong Ma 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第7期116-125,共10页
BACKGROUND Self-expandable metal stent(SEMS)as a bridge to surgery(BTS)has become a popular alternative to emergency surgery in the management of acute left-sided malignant colonic obstruction(MCO).However,it remains ... BACKGROUND Self-expandable metal stent(SEMS)as a bridge to surgery(BTS)has become a popular alternative to emergency surgery in the management of acute left-sided malignant colonic obstruction(MCO).However,it remains controversial for colonic stent as a BTS due to a lack of consensus and insufficient data.AIM To assess the clinical and oncological safety of SEMS insertion followed by elective resection for acute left-sided MCO.METHODS The data from 96 patients with acute left-sided MCO in our institution from January 2018 to May 2020 were analyzed retrospectively.They underwent colonic stenting as a bridge to elective surgery(BTS group:n=40)or emergency resection(ER group:n=56).Demographic characteristics,stoma rate,laparoscopy rate,postoperative complications,and oncological outcomes were compared between the two groups.RESULTS The two groups were comparable with regard to the demographics and tumor characteristics.The stoma rate was 7.5%in the BTS group vs 48.2%in the ER group(P<0.05).Primary anastomosis was performed in all patients in the BTS group,and only three patients underwent protective stoma in the BTS group.The BTS group had a significantly higher rate of laparoscopic surgery than the ER group(90%vs 57.1%,P<0.05),and the major postoperative complication rate was significantly higher in the ER group than in the BTS group(33.9%vs 15%,P=0.04).According to the Kaplan-Meier survival analysis and log rank test,no significant differences existed in the two groups with regard to the overall survival and disease-free survival.CONCLUSION The utilization of SEMS as a BTS is a useful alternative to emergency surgery in the treatment of acute left-sided MCO.SEMS insertion as a BTS can provide an effective and safe therapeutic option compared to emergency surgery. 展开更多
关键词 Self-expandable metal stents Bridge to surgery Emergency surgery Acute left-sided malignant colonic obstruction Malignant colonic obstruction
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Low rumen-degradation-rate starch reduces diarrhea and colonic inflammation by influencing the whole gastrointestinal microbiota and metabolite flow in dairy goats 认领 引用 被引量：2
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作者 Chunjia Jin Ziqi Liang +6 位作者 Xiaodong Su Peiyue Wang Xiaodong Chen Yue Wang Xinjian Lei Junhu Yao Shengru Wu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第7期2792-2809,共18页
Postruminal intestinal inflammation and hindgut acidosis caused by increased dietary starch supply and thereby increased quantities of ruminal degradable starch(RDS)in ruminants have been widely studied.Although the r... Postruminal intestinal inflammation and hindgut acidosis caused by increased dietary starch supply and thereby increased quantities of ruminal degradable starch(RDS)in ruminants have been widely studied.Although the roles of the microbiota in mediating hindgut health that are focused on the hindgut have been widely studied,the absence of whole gastrointestinal insight may influence the depth of research.We integrated the microbiome,metabolome,and host transcriptome changes in the rumen,jejunum,ileum,and colon to investigate the contributions of foregut changes to hindgut gene expression driven by gastrointestinal microbiota and metabolite flow.Forty goats were randomly assigned to receive either a low rumen-degradation-rate starch diet(LRDS,n=20)or a high rumen-degradation-rate starch diet(HRDS,n=20).Compared with the HRDS group,the LRDS group significantly decreased the diarrheal rate.Based on the mean values of the fecal scores,6 represented goats of LRDS group(fecal scores=(4.58±0.120))and 6 represented goats of HRDS group(fecal scores=(3.53±0.343))were selected for sampling and subsequent analysis.LRDS had significantly decreased the colonic pathologic scores.Transcriptomic analysis revealed that LRDS reduced jejunal,ileal,and colonic inflammatory responses.An increase in beneficial commensals and a decreased abundance of pathogenic genera in the small intestine and hindgut were found in goats fed the LRDS diet using 16S rRNA gene sequencing.To identify microbial transmission as well as the transmission of microbial metabolites,8 genera were identified as core genera according to their calculated niche width.Metabolomics analysis revealed that a total of 554 metabolites were identified among different gastrointestinal sites.Then,metabolites were incorporated into 3 modules:metabolites increased in the current site(ICS),unchanged inflow metabolites in the current site(UICS),and metabolites decreased in the current site(DCS).The results indicated that the UICS metabolites contributed more than 10%to host gene expression in the jejunum,ileum,and colon.When we further focused on the effects of colonic UICS metabolites on the colonic immune-related differentially expressed genes(DEGs),the results indicated that 1-palmitoylglycerol and deoxycholic acid contributed 60.74 and 11.5%to the colonic immune-related DEGs,respectively.Our findings provide a preliminary framework of microbial effects that includes the microbiota and their metabolite changes,especially reduced 1-palmitoylglycerol and deoxycholic acid,in the former gastrointestinal tract that could be involved in the alleviation of colonic inflammation in goats fed LRDS diets. 展开更多
关键词 ruminal degradable starch matter flow microbiome metabolome colonic inflammation
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Rumen-protected methionine and lysine supplementation to the low protein diet improves animal growth through modulating colonic microbiome in lambs 认领 引用 被引量：1
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作者 Zhibin Luo Huimin Ou +1 位作者 Zhiliang Tan Jinzhen Jiao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第4期1622-1633,共12页
Background Dietary protein level and amino acid(AA)balance are crucial determinants of animal health and productivity.Supplementing rumen-protected AAs in low-protein diets was considered as an efficient strategy to i... Background Dietary protein level and amino acid(AA)balance are crucial determinants of animal health and productivity.Supplementing rumen-protected AAs in low-protein diets was considered as an efficient strategy to improve the growth performance of ruminants.The colon serves as a crucial conduit for nutrient metabolism during rumen-protected methionine(RPMet)and rumen-protected lysine(RPLys)supplementation,however,it has been challenging to clarify which specific microbiota and their metabolites play a pivotal role in this process.Here,we applied metagenomic and metabolomic approaches to compare the characteristic microbiome and metabolic strategies in the colon of lambs fed a control diet(CON),a low-protein diet(LP)or a LP diet supplemented with RPMet and RPLys(LR).Results The LP treatment decreased the average daily weight gain(ADG)in lambs,while the LR treatment tended to elicit a remission in ADG.The butyrate molar concentration was greater(P<0.05),while acetate molar concentration(P<0.05)was lower for lambs fed the LP and LR diets compared to those fed the CON diet.Moreover,the LP treatment remarkably decreased total AA concentration(P<0.05),while LR treatment showed an improvement in the concentrations of methionine,lysine,leucine,glutamate,and tryptophan.Metagenomic insights proved that the microbial metabolic potentials referring to biosynthesis of volatile fatty acids(VFAs)and AAs in the colon were remarkably altered by three dietary treatments.Metagenomic binning identified distinct microbial markers for the CON group(Alistipes spp.,Phocaeicola spp.,and Ruminococcus spp.),LP group(Fibrobacter spp.,Prevotella spp.,Ruminococcus spp.,and Escherichia coli),and LR group(Akkermansia muciniphila and RUG099 spp.).Conclusions Our findings suggest that RPMet and RPLys supplementation to the low-protein diet could enhance the microbial biosynthesis of butyrate and amino acids,enriche the beneficial bacteria in the colon,and thereby improve the growth performance of lambs. 展开更多
关键词 Amino acid metabolism Colonic microbiome Lamb Metagenome Rumen-protected amino acids
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Comparative study of cylindrical vs circular ring magnets for colonic anastomosis in rats 认领 引用 被引量：1
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作者 Miao-Miao Zhang Ai-Hua Shi +3 位作者 Oliver J Muensterer Ibrahim Uygun Yi Lyu Xiao-Peng Yan 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第2期217-226,共10页
BACKGROUND Magnetic compression anastomosis(MCA)offers a simple and reliable technique for inducing anastomoses at any point along the digestive tract.Evidence regarding whether the design of the MCA device influences... BACKGROUND Magnetic compression anastomosis(MCA)offers a simple and reliable technique for inducing anastomoses at any point along the digestive tract.Evidence regarding whether the design of the MCA device influences the anastomosis effect is lacking.AIM To investigate any difference in the side-to-side colonic anastomosis effect achieved with cylindrical vs circular ring magnets.METHODS We designed cylindrical and circular ring magnets suitable for side-to-side colonic anastomosis in rats.Thirty Sprague-Dawley rats were randomly divided into a cylindrical group,circular ring group,and cylindrical–circular ring group(n=10/group).Side-to-side colonic anastomosis was completed by transanal insertion of the magnets without incision of the colon.Operation time,perioperative complications,and magnet discharge time were recorded.Rats were euthanized 4 weeks postoperatively,and anastomotic specimens were obtained.The burst pressure and anastomotic diameter were measured sequentially,and anastomosis formation was observed by naked eye.Histological results were observed by light microscopy.RESULTS In all 30 rats,side-to-side colonic anastomosis was completed,for an operation success rate of 100%.No postoperative complications of bleeding and intestinal obstruction occurred,and the postoperative survival rate were 100%.The operation time,magnet discharge time,anastomotic bursting pressure,and anastomotic diameter did not differ significantly among the three designs(P>0.05).Healing was similar across the groups,with gross specimens showing good anastomotic healing and good mucosal continuity observed on histological analysis.CONCLUSION This study found no significant difference in the establishment of rat side-to-side colonic anastomosis with the use of cylindrical vs circular ring magnets. 展开更多
关键词 Magnetosurgery Magnetic compression anastomosis Colonic anastomosis Magnet Rats
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Release profile and metabolism of bound polyphenols of oat bran during in vitro simulated gastrointestinal digestion and colonic fermentation 认领 引用
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作者 Yu Zhang Bing Bai +3 位作者 Kai Huang Sen Li Hongwei Cao Xiao Guan 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第4期1557-1565,共9页
Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols... Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols.In this study,in vitro simulated gastrointestinal digestion and colonic fermentation models were used to study the release profile and metabolism of BPs of oat bran.Significantly higher level of BPs was released during in vitro colon fermentation(3.05 mg GAE/g)than in gastrointestinal digestion(0.54 mg GAE/g).Five polyphenols were detected via LC-MS and their possible conversion pathways were speculated.Released BPs exhibited chemical antioxidant capacity.16S rRNA sequencing further revealed that Clostridium butyricum,Enterococcus faecalis,Bacteroides acidifaciens were the key bacteria involved in the release of BPs,and this was verified by whole-cell transformation.Our results helped to explain the possible mechanism of the health benefits of BPs in whole grains. 展开更多
关键词 Oat bran Bound polyphenols In vitro digestion Colonic fermentation Ferulic acid
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A new technique for ureteral reconstruction using a colonic mucosa graft in a beagle model 认领 引用
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作者 Xincheng Gao Yuancheng Zhou +5 位作者 Shuaishuai Chai Ming Yang Jiawei Chen Zehao Yu Xingyuan Xiao Bing Li 《Asian Journal of Urology》 CAS CSCD 2025年第4期554-561,共8页
Objective:To investigate the feasibility of using a colonic mucosa graft(CMG)for ureteral reconstruction and assess histological changes following the engrafted CMG in Beagles.Methods:Nine male Beagle dogs were random... Objective:To investigate the feasibility of using a colonic mucosa graft(CMG)for ureteral reconstruction and assess histological changes following the engrafted CMG in Beagles.Methods:Nine male Beagle dogs were randomly assigned to groups Ⅰ,Ⅱ,and Ⅲ(n=3).Resection of half of the ureteral wall caused a ventral ureteral defect.Ureteral defects with lengths of 3 cm,5 cm,and 10 cm were created in these groups,respectively.The CMG was harvested and used to repair the ureteral defects in an onlay fashion.After functional evaluation of the reconstructed ureter using CT urography at 3 months,6 months,and 12 months postoperatively,one Beagle from each group was euthanized using air embolization.Ureteral diameter measurements and the CMG shrinkage rate calculations were performed.Histological analysis was conducted to assess changes in the engrafted CMG.Results:All animals had no postoperative complications.CT urography showed normal renal function and a wide caliber ureter with no stricture or leakage.The ureteral diameter reconstructed by the CMG was larger than that of the proximal or distal normal ureter(p<0.05).The mean shrinkage rate of the CMG ranged from 11% to 14%.From 3 months to 12 months postoperatively,the colonic mucosal epithelium gradually underwent metaplasia into urothelium,and smooth muscle and neovascularization gradually developed beneath the mucosa. 展开更多
关键词 Colonic mucosa graft Ureteral stricture Ureteroplasty Ureteral reconstruction
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Surgical management of splenic flexure colonic malignancy 认领 引用
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作者 Sabrina Hui-Xian Cheok Salman Ahmed Abdul Jabbar +2 位作者 Neng-Wei Wong James Chi-Yong Ngu Nan-Zun Teo 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第12期43-52,共10页
There is a lack of consensus on the optimal surgical approach for splenic flexure malignancies.Surgeons face the challenge of balancing successful oncological outcomes with the morbidity and functional effects of exte... There is a lack of consensus on the optimal surgical approach for splenic flexure malignancies.Surgeons face the challenge of balancing successful oncological outcomes with the morbidity and functional effects of extended colonic resection,considering the variable‘watershed’vasculature and lymphatic anatomy of the splenic flexure.While there is an increasing body of evidence supporting the oncological safety of a more conservative segmental resection,most of the data stems from retrospective single center studies.This article reviews the management strategies and examines the evidence supporting various surgical approaches to splenic flexure malignancies. 展开更多
关键词 Colonic malignancy Surgical approach Splenic flexure malignancy Extended right hemicolectomy Left hemicolectomy Segmental resection Splenic flexure cancer
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Evaluation of efficacy and safety of different endoscopic polypectomy techniques for colonic polyps 认领 引用
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作者 De-Hui Ji Zhong-An Guan 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第9期79-90,共12页
BACKGROUND Colorectal polypectomy is fundamental to the prevention of colorectal cancer,utilizing several endoscopic techniques.Robust comparative data regarding the efficacy and safety of these modalities in clinical... BACKGROUND Colorectal polypectomy is fundamental to the prevention of colorectal cancer,utilizing several endoscopic techniques.Robust comparative data regarding the efficacy and safety of these modalities in clinical practice are limited.AIM To evaluate and compare the efficacy and safety of three endoscopic polypectomy techniques,namely,high-frequency electroresection(HFE),cold snare polypectomy(CSP),and endoscopic mucosal resection(EMR),for the treatment of colonic polyps.METHODS This single-center retrospective cohort study included adults who underwent endoscopic resection of pathologically confirmed colorectal polyps at Central Hospital Affiliated to Shandong First Medical University between January 2015 and December 2023.Patients were grouped by technique:HFE(n=107),CSP(n=106),and EMR(n=108).Standardized preoperative,intraoperative,and postoperative protocols were applied.Outcome measures included resection status(en bloc,R0,R1,and Rx),adverse events(immediate/delayed bleeding,perforation,and post-polypectomy coagulation syndrome),postoperative pain(visual analog scale at 1,3,and 5 hours),and 12-month recurrence rate.RESULTS Baseline demographics and polyp characteristics,except for polyp diameter,were comparable among groups.CSP achieved the highest en bloc resection rate,whereas HFE had a higher R0 resection rate.Polyp diameter was largest in the EMR group.Procedure duration was shortest with HFE.Adverse reactions were more frequent with HFE,particularly post-polypectomy bleeding and delayed perforation,whereas CSP demonstrated a superior safety profile and the lowest incidence of complications.Postoperative pain diminished in all groups over time but was consistently low for CSP and EMR.Recurrence rates were significantly higher in the EMR group vs CSP group,with HFE showing intermediate recurrence.CONCLUSION CSP offers the best safety profile and lowest recurrence rate among patients undergoing endoscopic resection of colorectal polyps,whereas HFE confers a high R0 resection rate but increased risk of adverse events.EMR remains essential for large polyps despite elevated recurrence.Technique selection should be tailored according to polyp characteristics and patient risk factors to optimize outcomes. 展开更多
关键词 Endoscopic polypectomy Colonic polyps High-frequency electroresection Cold snare polypectomy Endoscopic mucosal resection
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Taming colonic anastomotic leakage:Wisdom from the ancient Chinese legend of Yu the Great 认领 引用
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作者 Chao Jing Kun Liu 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第12期451-454,共4页
Colonic anastomotic leakage(AL)remains the most severe complication of colorectal surgery,significantly increasing morbidity,mortality,and healthcare burdens.The ideal solution-complete AL prevention without a defunct... Colonic anastomotic leakage(AL)remains the most severe complication of colorectal surgery,significantly increasing morbidity,mortality,and healthcare burdens.The ideal solution-complete AL prevention without a defunctioning stoma-has long eluded surgeons and patients.Hu et al proposed total enteric flow diversion using a modified ileostomy tube with an inflatable balloon,demonstrating its efficacy in completely preventing AL in porcine models.This innovation echoes the ancient legend of Yu the Great,a Chinese hero renowned for taming the Yellow River’s catastrophic floods.Unlike his father,who failed by merely building embankments to block water,Yu succeeded by dredging channels to redirect floods seaward.This paradigm of“diversion over obstruction”applies equally to AL prevention.Beyond Hu et al’s balloon technique,alternatives like the C-seal,the SafeHeal Colovac+anastomosis protection device and Tong et al’s biodegradable stent-based diverting techniques show promise in clinical trials.Key challenges remain:Diversion efficiency,device migration risks,and patient tolerance.We must accelerate such like breakthroughs in non-stoma diversion strategies to transform AL management. 展开更多
关键词 Colonic anastomotic leakage Diverting stoma Intraluminal bypass device Stent-based diverting technique Yu the Great Tames the Flood
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Thyroid nodules as predictors of adenomatous colonic polyps:A systematic review and meta-analysis 认领 引用
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作者 Hyder Osman Mirghani Salah Alghamdi 《World Journal of Clinical Cases》 2025年第33期56-62,共7页
BACKGROUND Thyroid nodules(TN)are increasingly diagnosed worldwide;investigating the association between TN and colon polyps could be helpful in early detection and management.To our knowledge no meta-analysis has ass... BACKGROUND Thyroid nodules(TN)are increasingly diagnosed worldwide;investigating the association between TN and colon polyps could be helpful in early detection and management.To our knowledge no meta-analysis has assessed the relationship between TN and adenomatous colonic polyps.AIM To assess the association between adenomatous colonic polyps,thyroid-stimulating hormone,and TN.METHODS We searched PubMed,MEDLINE,Cochrane Library,EBSCO,and the first 100 articles in Google for articles published in English from inception until April 2025.We included prospective cohorts,retrospective studies,case-control studies,and cross-sectional studies.The keywords thyroid nodules,adenomatous colon polyps,thyroid volume,metabolic syndrome,insulin resistance,and thyroid malignancy were used.RESULTS Out of 237 articles,25 full texts were reviewed,and 5 full texts were included in the final meta-analysis.No relationship was found between TN,colonic polyps,and thyroid-stimulating hormone levels[odd ratio(OR):1.78,95%confidence interval(CI):0.55-5.74,P=0.33].Colonic polyps were more common among patients with TN when addressing heterogeneity(OR:0.42,95%CI:0.30-0.52,P<0.001 and OR:0.08,95%CI:0.70-0.86,P=0.85).CONCLUSION TN were similar among patients with and without adenomatous colonic polyps.However,TN was more common among colon polyps when addressing the heterogeneity.Thyroid-stimulating hormone was not different between those with and without TN.Age,sex,adiposity,and smoking effects might explain the higher rate observed by the included studies.Further studies controlling for the same are needed. 展开更多
关键词 Adenomatous colonic polyps Thyroid stimulating hormone Thyroid nodule Predictors Risk factors
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