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Influence of diet-induced obesity and voluntary exercise training on cardiac lipids and mitochondrial function in mice 认领 引用 被引量：1
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作者 Nimna Perera Minh Deo +11 位作者 Surafel Tegegne Yow Keat Tham Natalie A.Mellett Anida Velagic Alex M.Parker Oliver K.Fuller Lauren V.Terry Casey L.Egan Peter J.Meikle Rebecca H.Ritchie Mark A.Febbraio Miles J.De Blasio 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第1期56-71,共16页
Background Obesity is a risk factor for developing cardiometabolic disease.Exercise training is pivotal in the treatment of obesity and is associated with reduced cardiovascular mortality.This study examined the effec... Background Obesity is a risk factor for developing cardiometabolic disease.Exercise training is pivotal in the treatment of obesity and is associated with reduced cardiovascular mortality.This study examined the effect of high-fat feeding on cardiac morphology and mitochondrial function,alongside the mitigating effects of voluntary exercise training.Methods Six-week-old male C57Bl/6 J mice commenced a high fat diet(HFD)or chow diet and were randomized to receive locked(sedentary)or unlocked(voluntary exercise training(VET))running wheels at 10 weeks of age.Mice were monitored until 30 weeks of age and euthanized for collection of tissues.Magnetic resonance imaging was performed to assess body composition,and echocardiography was performed to assess cardiac function.Results Compared with chow-fed animals,the HFD increased body weight and adiposity and decreased cardiolipins(CL)in the heart,which are required for maintaining adequate mitochondrial respiration.Importantly,VET reversed these effects and induced physiological cardiac hypertrophy.Cardiac mitochondrial respiratory chain analysis revealed decreased complexes II and IV activity following high fat feeding,while VET enhanced complex I activity,emphasizing the cardioprotective effect of exercise training in obesity.Conclusion This study uncovers mechanisms by which obesity and exercise impact cardiac mitochondrial health and suggests the mitochondria is a therapeutic target in obesity-related cardiovascular diseases. 展开更多
关键词 Cardiovascular disease Mitochondria Obesity Cardiolipin Exercise training
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Advances in the application of virtual reality technology in ophthalmic surgical skills training 认领 引用 被引量：1
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作者 Jia-Wen Wei Qing Zhang +4 位作者 Xiao-Yan Wang Ming-Xue Huang Jin-Hua Gan Wei-Hua Yang Wei Chi 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第2期393-404,共12页
Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid adv... Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid advancement of computer technology has enabled the integration of virtual reality(VR)into medical training,thereby revolutionizing ophthalmic surgical education through VRbased educational methods.VR technology offers a safe,risk-free environment for trainees to practice repeatedly,enhancing surgical skills and accelerating the learning curve without compromising patient safety.This research outlines the application of VR technology in ophthalmic surgical skills training,particularly in cataract and vitreoretinal surgery.Including assessing the effectiveness of intraocular surgery training systems,evaluating skills transfer to the operating room,comparing it with wet lab cataract surgery training,and enhancing non-dominant hand training for cataract surgery,among other aspects.Additionally,this paper will identify the limitations of VR technology in ocular surgical skills training,offer improvement strategies,and detail the advantages and prospects,with the objective of guiding subsequent researchers. 展开更多
关键词 virtual reality ophthalmology ophthalmic surgical skills training surgical simulation cataract surgery vitreoretinal surgery
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Comment on“Advances in the application of virtual reality technology in ophthalmic surgical skills training” 认领 引用
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作者 Van C.Lansingh Nicoletta Fynn-Thompson +2 位作者 Akshay Gopinathan Nair Minal ShahBaldota Stephen Chai 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第6期1216-1218,共3页
Dear Editor,We read with interest the article titled“Advances in the application of virtual reality technology in ophthalmic surgical skills training”[1].We congratulate the authors on their comprehensive review ... Dear Editor,We read with interest the article titled“Advances in the application of virtual reality technology in ophthalmic surgical skills training”[1].We congratulate the authors on their comprehensive review of an important and rapidly evolving topic:the use of virtual reality(VR)in cataract surgical training.We would like to expand on the discussion surrounding the“assessment of the cataract surgery training system’s effectiveness”. 展开更多
关键词 ophthalmic surgical skills training we ophthalmic surgical skills training virtual reality virtual reality vr training system effectiveness technological advancement cataract surgical trainingwe virtual reality technology
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Cardiometabolic response to high intensity functional training versus rowing-based high intensity interval training 认领 引用
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作者 Todd A.Astorino Madison Mower +1 位作者 Armando Flores Marissa Flannery 《Sports Medicine and Health Science》 CAS CSCD 2026年第3期311-318,共8页
This study compared the cardiometabolic response between rowing high intensity interval training(HIIT)and high intensity functional training(HIFT).Twenty two adults(age and.max=[25±7]yr and[40±9]mL/kg/min)un... This study compared the cardiometabolic response between rowing high intensity interval training(HIIT)and high intensity functional training(HIFT).Twenty two adults(age and.max=[25±7]yr and[40±9]mL/kg/min)underwent incremental exercise on a rowing ergometer to assess.max and peak power output(PPO).Subsequently,they underwent rowing HIIT(six 1 minutes[min]efforts at 85%PPO with 75 seconds[s]recovery)or HIFT(six 1 min efforts including pushups,jump squats,mountain climbers,and air squats with 75 s recovery).Gas exchange data,heart rate(HR),and blood lactate concentration(BLa)were acquired during exercise and postexercise.These regimens elicited 92%-96%HRmax,with higher peak HR([174±14]b/min vs.[167±15]b/min,p=0.002)and time spent≥85%HRmax([6.1±2.2]min vs.[5.0±2.8]min,p=0.03)for HIFT versus rowing HIIT.Results showed similar peak.between HIFT and HIIT([81±9]vs.[82±8].max,p=0.72),yet lower mean.([1.73±0.38]L/min vs.[1.93±0.50]L/min,p<0.001).Mean and peak ventilation(.)was significantly higher(p<0.05)with HIFT([62±13]L/min and[84±18]L/min vs.[53±15]L/min and[73±19]L/min).BLa was significantly higher with HIFT versus rowing HIIT(p<0.001)and was elevated 15 min post-exercise([7.0±3.0]mM vs.[3.5±1.1]mM).In healthy,active adults,HIFT elicits vigorous intensities similar to traditional HIIT. 展开更多
关键词 High intensity interval training Circuit training Blood lactate concentration Oxygen uptake Calorie expenditure
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Changes in knowledge and attitude after communitybased first-aid training:a prospective study with a 12-month follow-up 认领 引用
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作者 Shijiao Yan Wenning Fu +5 位作者 Ping Tan Chang Su Xuan Deng Jinlong Wang Chuanzhu Lyu Yanhong Yang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第3期215-222,共8页
BACKGROUND:This study aims to evaluate the immediate and 12-month effects of communitybased first-aid training on public knowledge and attitude,assess satisfaction,and identify factors associated with score changes.ME... BACKGROUND:This study aims to evaluate the immediate and 12-month effects of communitybased first-aid training on public knowledge and attitude,assess satisfaction,and identify factors associated with score changes.METHODS:This was a prospective study.In 2022-2023,a total of 2,010 community residents in Hainan Province received first-aid training and completed structured questionnaires at baseline,immediately after training,and at 3,6,and 12 months after training.First-aid knowledge was assessed through 33 items,with a maximum total score of 33.First-aid attitude was evaluated using seven items,totaling a maximum score of 21.Satisfaction was measured on a 5-point Likert scale.Paired-sample t-tests were used to compare baseline and post-training scores,repeated-measures analysis of variance(ANOVA)was used to examine time effects,and multiple linear regression was used to analyze factors associated with score changes.RESULTS:The satisfaction score with the training was high(mean score>4.3 for all items).The first-aid knowledge and attitude scores increased significantly after training(first-aid knowledge at baseline,14.90±7.63;immediately after training,20.70±5.72,P<0.001;and attitude at baseline,17.52±2.29;immediately after training,17.89±1.54,P<0.001).At 12 months after training,knowledge scores declined slightly compared with those immediately after training but remained above baseline(time effect P<0.001),whereas attitude scores remained stable(time effect P<0.001).Knowledge improvement was greater among middle-income participants and less among participants with lower levels of education,those in professional occupations,widowed individuals,or those who had previously received first-aid training.Attitude improvements were more pronounced among male participants,younger participants,and those in the agriculture or sales/service sectors.CONCLUSION:Community-based first-aid training improved public first-aid knowledge and attitude and was well received by participants.While knowledge levels declined somewhat over time,attitude remained relatively stable,highlighting the importance of continuous reinforcement training.Personalized reinforcement strategies may be particularly beneficial for individuals with lower levels of education,specific professional backgrounds,widowhood,or prior training experience to further enhance training effectiveness. 展开更多
关键词 First aid Knowledge Attitude Practice Training Longitudinal studies
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Near-Field Beam Training Based on Grating Lobes for XL-MIMO with Large Bandwidth 认领 引用
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作者 Wang Xiaoming Zhao Zhenjie +2 位作者 Jiang Rui Zhao Junhui Xu Youyun 《China Communications》 SCIE EI CSCD 2026年第3期151-168,共18页
Wideband extremely large-scale multipleinput multiple-output(XL-MIMO)is a promising technology for sixth-generation(6G)communications due to its high spectral efficiency and data rates.However,as the number of antenna... Wideband extremely large-scale multipleinput multiple-output(XL-MIMO)is a promising technology for sixth-generation(6G)communications due to its high spectral efficiency and data rates.However,as the number of antennas increase in XLMIMO,users are more likely to be in the near-field region,where beam training becomes more complex.Additionally,the expanding bandwidth introduces beam split and grating lobe effects.In this paper,we analyze the conditions for grating lobe generation,demonstrating the relationship between the grating lobe angle and bandwidth.As the bandwidth increases,a large portion of the visible angle range will produce grating lobes.The analysis shows that the grating lobe location always lies on the distance ring of the main lobe,and the grating lobe distance can be uniquely determined by the grating lobe angle on a single distance ring.Then we propose a wideband grating lobe beam training method based on controllable grating lobe generation mechanism,which applies to both the angle and distance dimensions to cover the user range.Simulation results show that this method achieves comparable rate performance with low overhead. 展开更多
关键词 beam training grating lobe near-field wideband communications XL-MIMO
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Intermittent Hypoxia-Hyperoxia Training Ameliorates Symptoms and Improves Cerebral Perfusion Status in Patients with Cerebral Venous Outflow Disorders:A Pilot Study 认领 引用
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作者 Milan Jia Chenxia Zhou +8 位作者 Hui Li Jing Lan Wenbo Zhao Lingyun Jia Sijie Li Changhong Ren Chen Zhou Lu Liu Xunming Ji 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期192-201,共10页
Objective Cerebral venous outflow disorders(CVOD)can impair cerebral perfusion and produce diverse,often debilitating symptoms,substantially reducing quality of life.Intermittent hypoxiahyperoxia training(IHHT)has dem... Objective Cerebral venous outflow disorders(CVOD)can impair cerebral perfusion and produce diverse,often debilitating symptoms,substantially reducing quality of life.Intermittent hypoxiahyperoxia training(IHHT)has demonstrated therapeutic potential across various pathologies and may represent a promising non-pharmacological approach for CVOD management.Methods Patients with imaging-confirmed CVOD underwent 14 IHHT sessions,each comprising four cycles of 10-minute hypoxia(11%O2)stimulation and 20-minute hyperoxia(38%O2).Physiological parameters and adverse events were monitored throughout the intervention.Clinical scales,24-hour ambulatory blood pressure,blood tests,jugular ultrasound,and perfusion imaging were assessed preand post-intervention.Results No participants experienced intolerable discomfort or severe adverse events;vital signs remained within normal ranges.No significant changes were observed in 24-hour blood pressure,blood cell counts,lipid profiles,or other blood markers.Notably,60%of patients(n=12)reported overall symptom improvement on the Patient Global Impression of Change scale.Headache severity,as measured by the visual analogue scale,significantly decreased(6.33±1.22 vs.4.89±2.03,P=0.016).In patients with internal jugular vein(IJV)stenosis,significant improvements were observed in regional cerebral blood flow(including the insula,occipital lobe,internal capsule,and lenticula)and left J3-segment IJV flow volume(107.27[47.50,160.00]vs.140.83[55.00,210.00]mL/min,P=0.011).Conclusion The current IHHT protocol is safe and well-tolerated in patients with CVOD.IHHT may alleviate CVOD-related symptoms by improving oxygen saturation,cerebral perfusion,and venous outflow pattern,supporting its potential as a non-invasive therapeutic strategy. 展开更多
关键词 Cerebral vascular disease Intermittent hypoxia-hyperoxia training Cerebral venous outflow disorders Cerebral perfusion Acclimatization
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Barriers and facilitators of the implementation of a leadership training program based on the Developing and Sustaining Nursing Leadership Best Practice Guideline:A qualitative study 认领 引用
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作者 Mi Zhao Zhenhui Tao +3 位作者 Jialei Feng Li Song Yangliu Li Dong Pang 《International Journal of Nursing Sciences》 CSCD 2026年第3期273-281,共9页
Objectives This study aimed to identify barriers and facilitators influencing the implementation of a leadership training program based on the Developing and Sustaining Nursing Leadership Best Practice Guideline for n... Objectives This study aimed to identify barriers and facilitators influencing the implementation of a leadership training program based on the Developing and Sustaining Nursing Leadership Best Practice Guideline for nurse managers.Methods The descriptive qualitative study was conducted through semi-structured individual interviews at a tertiary hospital in Beijing,China.We selected 16 nurse managers who had participated in a leadership training program using a purposive sampling method with a maximum variation strategy from March to August 2024.The collected data were analyzed using thematic analysis.Results This study identified 7 barriers and 17 facilitators guided by the Consolidated Framework for Implementation Research(CFIR).Barriers were identified as:intervention characteristics(complexity of content,excessive content,challenging assignments after training,gap between theory and practice,and time-consuming),and inner setting(unclear training goals,mentor incompetence).Key facilitators emerged from:intervention characteristics(internally developed content,Best Practice Guideline with high level of evidence,focusing on leadership competency for manager,logically connected design),outer setting(meeting participants’needs,networking with leadership authority,peer pressure),inner setting(effective communication,supported teamwork,tension for change,fitting the participants’value),characteristics of individuals(intrinsic motivation,self-efficacy,beginning or mid-stage of change),and process(planning developed in advance,full motivation,feedback and team debriefing)domains.Conclusions This study identified drivers of implementation for a leadership training program in the Chinese context.These findings support the successful delivery of this program and can inform future leadership training and support improvements in nurse managers’leadership. 展开更多
关键词 Barriers Consolidated framework for implementation research Facilitators Nursing leadership Qualitative study Training program
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AT-AER:Adversarial Training With Adaptive Example Reuse 认领 引用
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作者 Meng Hu Yanting Guo +3 位作者 Ran Wang Xizhao Wang Rihao Li Qin Wang 《CAAI Transactions on Intelligence Technology》 SCIE EI CSCD 2026年第3期769-783,共15页
Adversarial training(AT)is widely regarded as a crucial defense method for deep neural networks against adversarial attacks.Most of the existing AT methods suffer from the problems of insufficient coverage of perturba... Adversarial training(AT)is widely regarded as a crucial defense method for deep neural networks against adversarial attacks.Most of the existing AT methods suffer from the problems of insufficient coverage of perturbation space and robust overfitting.In view of this,we propose an AT framework with adaptive example reuse(AT-AER)to help improve the adversarial robustness of deep models.In AT-AER,a new concept named 2nd-order adversarial example(AE)is proposed by adaptively filtering AEs generated during the historical training phase,which achieves sufficient coverage of diverse attack directions.Meanwhile,by analysing the fundamental causes of robust overfitting,we propose the strategies of wave descending learning rate(WDLR),cosine increasing weight decay(CIWD)and cosine increasing attack strength(CIAS)in collaboration with AT-AER to optimise models.In addition,the Stochastic Weight Averaging(SWA)technique is introduced to further improve the stability of training.Finally,experiments on three benchmark datasets show that AT-AER exhibits significant advantages in the face of strong adversarial attacks.Its adaptive mechanism effectively alleviates the phenomenon of robust overfitting where the performance difference between the best model and the last model is less than 1%.The study further reveals that using traditional weak attacks(e.g.,FGSM)to evaluate the robustness of models may lead to a false sense of reliability,indicating the necessity of using strong attacks for robustness evaluation.This study provides a solution for AT that balances efficiency and performance. 展开更多
关键词 adversarial training example reuse 2nd‐order adversarial example adversarial robustness
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Corrigendum to“ACtriplet:An improved deep learning model for activity cliffs prediction by integrating triplet loss and pre-training”[J.Pharm.Anal.,15(2025)101317] 认领 引用
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作者 Xinxin Yu Yimeng Wang +3 位作者 Long Chen Weihua Li Yun Tang Guixia Liu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期889-890,共2页
Description of the correction:The authors wish to make the following corrections to improve clarity and ensure appropriate attribution of related prior work.These corrections do not affect the results,analyses,or conc... Description of the correction:The authors wish to make the following corrections to improve clarity and ensure appropriate attribution of related prior work.These corrections do not affect the results,analyses,or conclusions of the original article.1.Addition of relevant prior work in the Introduction section:After the sentence:“Schroff et al.[15]developed a triplet-based loss function for this problem to help the model go to a better learning representation,achieving better results and new record accuracy on multiple datasets.”The following text should be added:“Shen et al.[37,38]first proposed activity-cliff awareness loss and ACANet,which explicitly defined activity-cliff triplets based on activity differences and extended the triplet loss framework to regression tasks by adaptively adjusting the margin.In their formulation,the margin is dynamically modulated to pull samples closer or push them farther apart according to their label differences,enabling effective awareness of activity cliffs in molecular activity prediction.” 展开更多
关键词 acanet activity cliff awareness loss pre training molecular activity prediction activity cliffs prediction improve clarity relevant prior work regression tasks
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Rotarod training reverses corticosterone-induced motor deficits via oligodendrocyte lineage cell modulation 认领 引用
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作者 Jada Chia-Di Lee Benson Wui-Man Lau +6 位作者 Suk-Yu Yau Joseph Wai-Hin Leung Harmony Kai-Hei Wong Dalinda Isabel Sanchez Vidana Tatia M.C.Lee Wu-Tian Wu Kwok-Fai So 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2440-2447,共8页
Adult-born oligodendrocytes are continuously produced in the brains of rodents.The functional role of these cells has been linked to the motor-related activities of healthy animals and is vital for acquiring new motor... Adult-born oligodendrocytes are continuously produced in the brains of rodents.The functional role of these cells has been linked to the motor-related activities of healthy animals and is vital for acquiring new motor skills.However,the relationship between these cells and the control of motor-related activities has not been investigated in pathological conditions.Therefore,the aim of this study is to investigate the role of oligodendrocytes in depression-related motor deficits and the effects of training.Psychomotor retardation is a key symptom of depression.Consistent with the impairments observed in rodent motor performance,the proliferation and activation of adult-born oligodendrocytes are altered in a corticosterone-induced stress paradigm.Therapeutic rotarod training can alleviate these symptoms by reversing the aforementioned changes.Notably,these alterations are particularly pronounced in layer I of the motor cortex.Thus,this study provides evidence of the potential functional involvement of adult-born oligodendrocytes in the motor impairments observed in the depressed animals.Additionally,it offers preliminary results for further investigation into layer I of the motor cortex in relation to these pathological conditions. 展开更多
关键词 corticosterone-induced stress exercise major depressive disorder motor cortex motor deficits motor training myelination oligodendrocyte lineage cells oligodendrocyte precursor cells psychomotor retardation
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Application and Practice of the Ladder Teaching System Based on Standardized Sampling in Pathological Residency Standardized Training 认领 引用
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作者 Qiushuang Ma Bingjuan Zhou +5 位作者 Yingying Lan Jirui Sun Bingxin Zhang Jinmei Li Wenming Zhao Jinku Zhang 《Journal of Contemporary Educational Research》 2026年第6期392-398,共7页
Pathological specimen sampling is the primary and key link of pathological diagnosis,as well as the most core and basic fundamental skill in the standardized training of resident pathologists.The standardization of sa... Pathological specimen sampling is the primary and key link of pathological diagnosis,as well as the most core and basic fundamental skill in the standardized training of resident pathologists.The standardization of sampling directly determines the quality of pathological sections,the accuracy of diagnosis,and the construction of trainees’clinical pathological thinking.At present,most resident trainees have common problems such as weak sampling concepts,non-standard operations,insufficient lesion identification,and sampling omissions,which constitute the main bottleneck restricting the quality of pathological residency training.Based on the growth law of pathological talents,the Pathology Residency Training Base of Baoding First Central Hospital integrates standardized sampling teaching into the whole three-year residency training,and constructs a characteristic sampling training system of“admission desensitization–ladder-based practical operation–subspecialty competency–quality control review–closedloop improvement”to target and solve trainees’problems including weak foundation,random operation and unclear key points.This paper focuses on expounding the core value of standardized sampling in consolidating the foundation of pathological residency training,and summarizes the base’s hierarchical sampling training mode,quality control management measures and practical effects,so as to provide a promotable practical scheme for domestic pathological residency training bases to strengthen basic teaching and improve trainees’core professional competencies. 展开更多
关键词 Clinical pathology Standardized residency training Specimen sampling Basic skill training Quality control
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Isolated knee extension resistance training and functional outcomes in patients with heart failure:A narrative review 认领 引用
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作者 Arnengsih Nazir 《World Journal of Cardiology》 2026年第6期35-46,共12页
Heart failure is a major global health problem resulting in reduced exercise tolerance,functional capacity,and health-related quality of life(HRQoL).In addition to central cardiac dysfunction,peripheral skeletal muscl... Heart failure is a major global health problem resulting in reduced exercise tolerance,functional capacity,and health-related quality of life(HRQoL).In addition to central cardiac dysfunction,peripheral skeletal muscle abnormalities,particularly involving the knee extensors,substantially contribute to physical limitation.This narrative review synthesizes current evidence regarding the effects of isolated knee extension resistance training(KERT)on muscle strength,exercise tolerance,and HRQoL in patients with chronic heart failure.A comprehensive but non-systematic search of PubMed,Scopus,and Google Scholar was conducted to identify English-language clinical studies evaluating isolated or predominantly knee extensor-based resistance training with relevant functional outcomes.Evidence indicates that isolated KERT is a safe and clinically meaningful intervention that consistently improves muscle strength and submaximal functional capacity,primarily through peripheral adaptations such as enhanced metabolic efficiency and reduced symptom burden during daily activities.However,substantial heterogeneity in training protocols may partly explain variability in reported outcomes.Changes in peak oxygen uptake are inconsistent,reflecting the specificity of local muscular adaptations.Improvements in HRQoL,particularly in physical functioning domains,are frequently reported.Overall,isolated KERT represents a valuable complementary component of cardiac reha-bilitation programs,although further research is needed to optimize protocols and determine long-term effects. 展开更多
关键词 Cardiac rehabilitation Exercise tolerance Heart failure Quality of life Resistance training
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Relationship of strength training lifetime exposure with functional outcomes and mobility over 4 years:Data from the Osteoarthritis Initiative 认领 引用 被引量：1
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作者 Daniel Kiehl Zane Thompson +3 位作者 Alisa J.Johnson Kimberly T.Sibille Kevin R.Vincent Heather K.Vincent 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第4期300-309,共10页
Background This study compared knee osteoarthritis(OA)outcomes specific to pain,physical function,and quality of life in later life based on strength training(ST)participation over a lifetime.Methods Participants from... Background This study compared knee osteoarthritis(OA)outcomes specific to pain,physical function,and quality of life in later life based on strength training(ST)participation over a lifetime.Methods Participants from the Osteoarthritis Initiative(n=3192)were grouped by ST engagement during ages 12–18 years,19–34 years,35–49 years,and 50+years.Participants were categorized as:No ST(no ST at any point;61.7±9.0 years(mean±SD)),Some ST(engaged in ST during 1–3 life stages;58.9±8.7 years),and Lifelong ST(consistently engaged in ST across all life stages;55.6±8.1 years).Measures were collected at baseline and Year 4:Western Ontario and McMaster Universities Osteoarthritis Index Scores(WOMAC;pain,daily activities),Knee Injury and Osteoarthritis Outcome Score(KOOS;sports,recreation),Physical Activity Score for the Elderly(PASE),Short Form-12 Physical Component Score(SF-12 PCS),mobility disability,chair rise time,and walking speed(20 m and 400 m).Results At Year 4,the Lifelong ST group reported better WOMAC activity scores in the right knee along with better WOMAC pain,KOOS sportsecreation,and PASE scores compared to other groups(p<0.05).The Lifelong ST group had the lowest incidence of mobility disability of all groups(0.8%vs.2.3%–4.1%;p=0.015)and maintained the fastest walking speeds in Year 4.Conclusion For those with knee OA,ST throughout life may help preserve function and mobility,allowing for greater physical activity engagement while keeping pain levels relatively lower. 展开更多
关键词 Osteoarthritis Strength training Pain Physical function Gait
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Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle 认领 引用 被引量：2
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作者 Mutsumi Katayama Elena Caria +8 位作者 Dimitri Van Simaeys Anna Yagüe Sanz Romain Barrès Kenneth Caidahl Oscar P.B.Wiklander Samir El Andaloussi Per-Olof Berggren Juleen R.Zierath Anna Krook 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第1期40-55,共16页
Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-in... Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise. 展开更多
关键词 Extracellular miRNA Endurance training Human skeletal muscle miR-136-3p Nardilycin convertase(NRDC)
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Post-stroke rehabilitative mechanisms in individualized fatigue level-controlled treadmill training in rats 认领 引用
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作者 Yuchen Xu Yulong Peng +6 位作者 Yuanfa Yao Xiaoman Fan Minmin Wang Feng Gao Mohamad Sawan Shaomin Zhang Xiaoling Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4924-4932,共9页
Clinically,individualized training improves post-stroke motor function rehabilitation efficiency.However,the mechanisms underlying how individualized training facilitates recovery remain relatively unclear.Here,we exp... Clinically,individualized training improves post-stroke motor function rehabilitation efficiency.However,the mechanisms underlying how individualized training facilitates recovery remain relatively unclear.Here,we explored the cortical and corticomuscular rehabilitative effects of post-stroke motor function recovery during individualized training using a rat model of intracerebral hemorrhage.Forced training or individualized fatigue-controlled training was provided from days 2 to 14 post-stroke.The fatigue-controlled training group exhibited superior motor function recovery and less central fatigue compared with the forced training group.Electroencephalograph power spectrum density slope analysis demonstrated better inter-hemispheric balance in the fatigue-controlled training group than in the forced training group.Directed corticomuscular coherence analysis indicated that training-induced fatigue led to a short-term downregulation of descending directed corticomuscular coherence and an upregulation of ascending directed corticomuscular coherence.In the long term,excessive fatigue hindered the recovery of descending control in the affected hemisphere.In conclusion,the individualized strategy of peripheral fatigue-controlled training achieved better motor function recovery,which may be attributed to the mitigation of central fatigue,optimization of inter-hemispheric balance,and enhancement of descending control in the affected hemisphere.This is the first study to investigate the mechanisms underlying individualized rehabilitative effects at the cortical and corticomuscular levels.Our findings suggest that personalized training protocols that are tailored to manage fatigue levels may substantially enhance post-stroke motor efficiency.They also provide a mechanistic foundation for developing fatigue-monitored,individualized rehabilitation programs in clinical practice. 展开更多
关键词 central fatigue corticomuscular coherence electroencephalography fatigue individualized training interhemispheric balance motor function recovery peripheral fatigue stroke rehabilitation treadmill training
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Comment on“Relationship of strength training lifetime exposure with functional outcomes and mobility over 4 years:Data from the Osteoarthritis Initiative” 认领 引用
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作者 Jiang Zhu Lunyu Li +1 位作者 Jinyu Feng Liangjun Mou 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第4期310-311,共2页
Kiehl and colleagues1 utilized data from the Osteoarthritis Initiative(OAI)to address a clinically significant question:Is lifetime participation in strength training(ST)associated with improved trajectories of pain,f... Kiehl and colleagues1 utilized data from the Osteoarthritis Initiative(OAI)to address a clinically significant question:Is lifetime participation in strength training(ST)associated with improved trajectories of pain,function,and mobility in individuals with knee osteoarthritis(OA)?Among 3192 participants,those classified as“Lifelong ST”(n=142)demonstrated superior 4-year patient-reported outcomes and exhibited the lowest incidence of mobility disability(0.8%vs 2.3%-4.1%).Notably,they also maintained the fastest walking speeds at Year 4. 展开更多
关键词 strength training functional outcomes lifetime exposure Osteoarthritis Initiative strength training st associated knee osteoarthritis knee osteoarthritis oa osteoarthritis initiative oai
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Does longer-muscle length resistance training cause greater longitudinal growth in humans?A systematic review 认领 引用
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作者 Milo Wolf Patroklos Androulakis Korakakis +6 位作者 Michael D.Roberts Daniel L.Plotkin Martino V.Franchi Bret Contreras Menno Henselmans Stian Larsen Brad J.Schoenfeld 《Sports Medicine and Health Science》 CAS CSCD 2026年第1期34-42,共9页
Background:This paper aimed to systematically review the literature regarding the effects of resistance training(RT)performed at longer-muscle length(LML)versus shorter-muscle length(SML)on proxy measurements for long... Background:This paper aimed to systematically review the literature regarding the effects of resistance training(RT)performed at longer-muscle length(LML)versus shorter-muscle length(SML)on proxy measurements for longitudinal hypertrophy.Methods:We included studies that satisfied the following criteria:(1)be a resistance training intervention with a comparison of LML vs SML-RT;(2)assess both fascicle length(FL)and muscle size pre-and post-intervention;(3)involve healthy adults aged≥18 years;(4)be published in an English-language journal,and;(5)have a minimum training intervention duration of 4 weeks.Three databases were searched in February 2024(Google Scholar,PubMed/Medline,Scopus)for relevant articles,alongside'forward'and'backward'citation searching of articles included and additions via authors'personal knowledge.The results of studies were described narratively,compared,and contrasted.Eight studies met the inclusion criteria,totaling a sample size of 120.Results:Our results suggest that both muscle size and fascicle length increases may be greater following LML-RT versus SML-RT,suggesting LML-RT may lead to greater longitudinal hypertrophy than SML-RT.Notably,evidence is largely mixed;no studies to date have attempted to estimate serial sarcomere number changes from LML versus SML-RT,and all but one study used linear extrapolation methods to estimate FL,which has questionable validity.Therefore,the structural adaptations underlying hypertrophy from LML-RT remain undetermined.Conclusion:In conclusion,results suggest that LML-RT may be superior to SML-RT for inducing muscle hypertrophy and,more specifically,longitudinal growth,though evidence is mixed. 展开更多
关键词 sarcomerogenesis Lengthened partials Range of motion Strength training
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Structural Modulation of Magnetic Softness in Fe‐Based Amorphous Alloys via Pulse Current Training 认领 引用
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作者 Shumin Ye Zida Zhang +11 位作者 Rie Umetsu Huaping Ding Xiong Liang Yuanfei Cai Yan Zhang Yuqiang Yan Zhenduo Wu Jiang Ma Xing Tong Haibo Ke Hai‐Yang Bai Wei‐Hua Wang 《Rare Metals》 SCIE EI CAS CSCD 2026年第6期808-818,共11页
Fe‐based amorphous alloys,despite their intrinsically low magnetocrystalline anisotropy,suffer from quasi‐dislocation dipoles and localized stress fields that impede domain‐wall motion and increase coercivity.Here,... Fe‐based amorphous alloys,despite their intrinsically low magnetocrystalline anisotropy,suffer from quasi‐dislocation dipoles and localized stress fields that impede domain‐wall motion and increase coercivity.Here,we introduce pulse current training(PCT)as an energy‐efficient technique to overcome these limitations in a Fe76Si9B10P5ribbon.As quenched ribbons exhibit a coercivity Hc~10.6 A m−1and the optimized infrared annealing reduced Hc~2 A m−1with a saturation magnetization Ms~162 emu g−1.By applying controlled square‐wave current pulses(J=7000 A cm−2,Tw:Tp=1:2,Tp=0.06 s)over 18-50 cycles,PCT further reduces Hc to below 1 A m−1and increases Ms to 179 emu g−1.Within a moderate‐cycle window,the ribbons maintain sufficient bendability for a practical core.Ultra‐rapid thermal annealing performed as a control reduces Hc to~2.5 A m−1but does not reach the level achieved by PCT,indicating that rapid heating alone cannot account for the superior magnetic softening.Finite‐element simulations and structural characterization show that PCT produces rapid and nearly uniform Joule heating,enabling efficient structural relaxation and enhanced medium‐range order while retaining an overall amorphous structure.Compared with conventional annealing,PCT implements a distinct,pulse energy injection pathway on the potential energy landscape,enabling more controllable tuning of amorphous configurations.This work establishes PCT as a versatile approach for tailoring both magnetic and mechanical properties in amorphous soft magnetic materials,paving the way for their optimized application in advanced electromagnetic devices. 展开更多
关键词 amorphous alloys microstructures pulse current training soft magnetic properties
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Investigating the correlation between neural and muscular activities during bilateral arm training in stroke survivors:A cross-sectional study 认领 引用
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作者 Yan Tang Tara Scarlette Rosalyn Chen +3 位作者 Yi Xu Pu Wang Peng Dou Dongfeng Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3026-3034,共9页
Stroke patients experience varying degrees of upper limb functional impairment.Although bilateral arm training can help stroke patients recover movement after stroke,little is known about the way in which the brain an... Stroke patients experience varying degrees of upper limb functional impairment.Although bilateral arm training can help stroke patients recover movement after stroke,little is known about the way in which the brain and muscles work together during this type of training.To address this,we conducted a cross-sectional study at The Seventh Affiliated Hospital,Sun Yat-sen University in China,where we observed the connection between brain and muscle activity during bilateral upper limb training in 21 stroke patients and 17 healthy controls.We used functional near-infrared spectroscopy and surface electromyography to measure changes in cerebral cortex oxygenation and upper limb muscle contraction signals,respectively.The results showed that,compared with the healthy control group,stroke patients had reduced functional connectivity and more irregular muscle activity in the affected flexor muscle during bilateral upper limb training.Moreover,we found a significant correlation between the surface electromyographic signal characteristics of upper limb muscles and cerebral oxygenation indicators of multiple brain regions in stroke patients.These findings indicate that bilateral upper limb training is an effective rehabilitation method that improves upper limb motor function in stroke patients by promoting brain functional connectivity and improving muscle activity patterns. 展开更多
关键词 bilateral arm training coordination entropy functional connectivity hemiparesis interaction near-infrared spectroscopy neuroplasticity stroke surface electromyography
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