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Activatable smart contrast agents for photoacoustic imaging 认领 引用
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作者 Donghyeon Oh Jihye Lee +3 位作者 Suyoung Park Juyoung Yoon Won Jong Kim Chulhong Kim 《Smart Molecules》 CSCD 2026年第2期12-39,共28页
Photoacoustic imaging(PAI)uniquely merges the molecular contrast of optical absorption with the centimeter-scale penetration afforded by ultrasound detection,enabling noninvasive visualization of deep physiology beyon... Photoacoustic imaging(PAI)uniquely merges the molecular contrast of optical absorption with the centimeter-scale penetration afforded by ultrasound detection,enabling noninvasive visualization of deep physiology beyond the reach of purely optical modalities.Conventional photoacoustic(PA)contrast agents have been used to improve detection sensitivity relative to endogenous absorbers,but their fixed optical properties limit adaptation to heterogeneous or evolving disease microenvironments.Activatable PAI contrast agents overcome this drawback by switching their absorbance spectra in real time in response to exogenous triggers(near-infrared light,heat,ultrasound,and electromagnetic fields)or endogenous microenvironmental cues(hypoxia,pH,reactive oxygen species,glutathione,and disease-related enzymes).These dynamic features extend PAI beyond static signal enhancement,enabling user-controlled activation,suppression of background interference,and access to functional or molecular biomarkers that conventional agents cannot provide.This review surveys recent advances in the molecular design,activation chemistry,and biomedical applications of these“activatable”probes,highlighting strategies for noninvasive diagnosis,multimodal imaging,remote actuation,and synergistic theranostics.Looking ahead,the next frontier lies in pathology-tailored probes that can noninvasively reveal biomarkers inaccessible to current methods,as illustrated by early successes in atherosclerosis imaging.Achieving this translation will require optimizing probe safety and clearance,standardizing characterization protocols,and integrating hybrid imaging platforms with quantitative PA tomography to generate reliable diagnostic metrics. 展开更多
关键词 activatable photoacoustic contrast agent photoacoustic imaging probing trigger
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Heptanuclear iron complex as a potential contrast agent for MRI 认领 引用 被引量：1
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作者 Ekaterina E.Batueva Alsu R.Sharipova +2 位作者 Olga A.Turanova Alexander E.Klimovitskii Alexander N.Turanov 《Magnetic Resonance Letters》 EI CAS 2026年第3期24-33,共10页
A heptanuclear complex of the composition[Fe(Ⅱ)(CN)6{Fe(Ⅲ)](L)}6](SCN)2,where L=dianion N,N-bis(1-hydroxy-2-benzylidene)-1,7-diamino-4-azageptane has been studied as a potential contrast agent for magnetic ... A heptanuclear complex of the composition[Fe(Ⅱ)(CN)6{Fe(Ⅲ)](L)}6](SCN)2,where L=dianion N,N-bis(1-hydroxy-2-benzylidene)-1,7-diamino-4-azageptane has been studied as a potential contrast agent for magnetic resonance imaging.The longitudinal and transverse relaxation times of water in a colloidal solution of this molecular magnet with sodium dodecyl sulfate were measured by 1H nuclear magnetic resonance spectroscopy,depending on the concentration,and its relaxivity was calculated.The obtained relaxation values indicate that this complex is a promising candidate for use as a contrast agent in magnetic resonance imaging.This preliminary study is aimed at identifying the possibility of applying the heptanuclear complex as a magnetic resonance imaging contrast agent. 展开更多
关键词 Heterometallic complex Iron ion Relaxivity MRI contrast agent
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Effect Analysis of Optimization Strategies for Contrast Agent Usage Based on the PDCA Cycle in CCTA 认领 引用
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作者 ZHANG Hengyu GAO Yaning 《外文科技期刊数据库（文摘版）医药卫生》 2026年第4期037-041,共5页
Objective: To investigate the practical efficacy of applying the PDCA systematic management cycle to coronary CT angiography in standardizing and reducing contrast agent administration volumes, while comprehensively e... Objective: To investigate the practical efficacy of applying the PDCA systematic management cycle to coronary CT angiography in standardizing and reducing contrast agent administration volumes, while comprehensively evaluating whether the resulting images meet diagnostic requirements and assess the safety of the examination process. Methods: Clinical data from 100 patients undergoing CCTA at our hospital from October 2024 to June 2025 were analyzed. All subjects were divided into two groups based on whether their department had implemented a new contrast agent management protocol based on the PDCA framework: 50 patients examined before implementation formed the control group, and 50 patients examined after implementation formed the observation group. Key parameters—including total iodine contrast agent dosage, injection rate, image quality scores, objective noise levels, and incidence of adverse events—were systematically compared between the two groups. Results: After implementing the PDCA optimization strategy, both core parameters (average contrast agent dosage and average injection rate) showed significant reductions in the observation group compared to the control group, with statistically significant differences established. No statistical difference was observed in subjective image quality ratings (excellent/profine), but the observation group demonstrated a higher proportion of cases meeting predefined vascular enhancement criteria. Additionally, compared to...The overall incidence of contrast agent-related adverse reactions showed a declining trend in the observation group. Conclusion: Integrating the PDCA cycle into the CCTA examination protocol to optimize contrast agent usage achieves significant reductions in both dosage and injection rate without compromising diagnostic accuracy. This management approach demonstrates substantial practical value in enhancing patient safety during examinations and promoting rational utilization of medical resources. 展开更多
关键词 PDCA cycle CT coronary angiography contrast agent dose control image evaluation
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Analysis of the Effect of the Contrast Agent Usage Optimization Strategy Based on PDCA Cycle in CCTA 认领 引用
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作者 LV Xing NIAN Guihong +1 位作者 LI Shun CHEN Shuang 《外文科技期刊数据库（文摘版）医药卫生》 2026年第4期117-122,共6页
Objective To evaluate the application efficacy of a contrast agent dosage optimization strategy based on the PDCA cycle in coronary computed tomography angiography (CCTA) examinations, providing reference for improvin... Objective To evaluate the application efficacy of a contrast agent dosage optimization strategy based on the PDCA cycle in coronary computed tomography angiography (CCTA) examinations, providing reference for improving examination quality and ensuring patient safety. Methods A total of 100 CCTA patients admitted from January to September 2024 were enrolled as the control group, while another 100 patients admitted from October 2024 to June 2025 were assigned to the experimental group, where the PDCA-based contrast agent dosage optimization strategy was implemented. The contrast agent dosage, image quality, incidence of adverse reactions, and patient satisfaction were compared between the two groups. Results The average contrast dose in the experimental group was significantly lower than that in the control group (P<0.001), with a higher rate of excellent and good results (χ²=13.5, P<0.05);the frequency of complications also decreased markedly (χ²=7.8, P<0.05), and overall service satisfaction scores showed significant improvement (t=-15.8, P<0.001). Conclusion The PDCA cycle management enables precise control of contrast agent dosage and significantly enhances image quality, demonstrating substantial clinical applicability. 展开更多
关键词 PDCA cycle coronary CT angiography contrast agent optimization image quality adverse reactions
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Gd(OH)3and Gd(OH)3-based heterostructures:Synthesis and their photocatalytic,drug delivery,contrast agents,and toxicity studies 认领 引用 被引量：1
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作者 Shaidatul Najihah Matussin Mohammad Hilni Harunsani Mohammad Mansoob Khan 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第6期1100-1109,I0001,共10页
The syntheses of Gd(OH)3and Gd(OH)3-based nanomaterials have been reported and these materials have been developed as excellent MRI contrast agents.Due to the close interrelation between their morphology and pro... The syntheses of Gd(OH)3and Gd(OH)3-based nanomaterials have been reported and these materials have been developed as excellent MRI contrast agents.Due to the close interrelation between their morphology and properties,it has resulted in the development of various particle sizes and shapes of Gd(OH)3and Gd(OH)3-based nanomaterials.This has led to the extension of the uses of the materials to photocatalysis,drug delivery,and CT image contrast agents.Accordingly,these applications have been compiled and discussed in depth in this review.The potential of these materials in the above applications has started to attract significant attention.Moreover,the compilation of in-vitro toxicity studies from the literature was also discussed to facilitate the biocompatibility of the developed Gd(OH)3nanomaterials.However,despite the rapid progress of Gd(OH)3and Gd(OH)3-based nanomaterials,there are still knowledge gaps in certain areas.Therefore,this review provides insights into the recent development of Gd(OH)3and Gd(OH)3-based nanomaterials to aid in accelerating novel developments. 展开更多
关键词 Gadolinium(Ⅲ)hydroxide Gd(OH)3 Gd(OH)3-based nanomaterials Photocatalysis Drug delivery Contrast agent In-vitro toxicity Rare earths
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Ultrasmall Superparamagnetic Iron Oxide Nanoparticles as Positive Contrast Agents in Low‐Field Magnetic Resonance Imaging 认领 引用
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作者 Ogechukwu Ngwu‐Hyacinth Aaron Alford +7 位作者 Caleb SRowe Ryan Willoughby S.Abdollah Mirbozorgi Steven ARothenberg Jesse Jones Abin Sajan Venkatesh P.Krishnasamy Mark Bolding 《iRADIOLOGY》 CSCD 2025年第5期372-387,共16页
Ultrasmall superparamagnetic iron oxide nanoparticles(usSPIONs)are promising alternatives to gadolinium‐based contrast agents for positive contrast enhancement in magnetic resonance imaging(MRI).Unlike larger SPIONs ... Ultrasmall superparamagnetic iron oxide nanoparticles(usSPIONs)are promising alternatives to gadolinium‐based contrast agents for positive contrast enhancement in magnetic resonance imaging(MRI).Unlike larger SPIONs that primarily function as T2/T2*negative contrast agents,usSPIONs with core diameters below 5 nm can effectively shorten T1 relaxation times,producing bright signals in T1‐weighted images.This distinct behavior stems from their unique magnetic properties,including single‐domain configurations,surface spin canting,and rapid Néel relaxation dynamics,which are particularly enhanced at low magnetic field strengths.The biocompatibility of iron oxide,efficient renal clearance pathways,and versatility for surface functionalization offer potential advantages over gadolinium‐based agents,especially regarding safety concerns related to nephrogenic systemic fibrosis and gadolinium deposition.These nanoparticles show particular promise for applications in lowfield MRI,vascular imaging,targeted molecular imaging,and theranostic platforms.Although challenges remain in optimizing synthesis methods for consistent production of monodisperse usSPIONs with tailored surface chemistry,ongoing research continues to advance their potential for clinical translation.This review explores the mechanisms,synthesis approaches,applications,and future perspectives of usSPIONs as positive contrast agents in MRI. 展开更多
关键词 iron oxide nanoparticle low‐field MRI magnetic resonance imaging magnetite and maghemite positive contrast agent superparamagnetic iron oxide nanoparticle T1 MRI contrast agent T1 relaxivity ultrasmall superparamagnetic iron oxide nanoparticle
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Erbium chelate as a high-performance spectral CT contrast agent for gastrointestinal tract imaging 认领 引用
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作者 Xiaoling Che Didi Gu +6 位作者 Zhongyuan Zhang Liu Zhao Wenqian Ru Xin Zhu Qiuyu Meng Chunmei Yang Lu Yang 《Journal of Rare Earths》 SCIE EI CAS CSCD 2025年第11期2489-2499,I0006,共11页
Spectral computed tomography(CT)imaging as an advanced and non-invasive technique is of importance in the diagnosis of disease.Therefore,it is significant to develop safe and high-performance contrast agents for spect... Spectral computed tomography(CT)imaging as an advanced and non-invasive technique is of importance in the diagnosis of disease.Therefore,it is significant to develop safe and high-performance contrast agents for spectral CT imaging.Herein,we synthesized a small-molecule erbium chelate(ErDOTA dimeglumine),with the advantages of favorable colloidal and structure stability,good biocompatibility and biosafety,and sensitive spectral CT imaging ability in vitro and in vivo.Erbium chelate exhibits strong X-ray attenuation capability and the energy-dependent attenuation in the range of 40-160 keV due to the high K-edge value of Er(57.5 keV).Especially,the slope of the Hounsfield unit(HU)curve for erbium chelate is 1.5 times that of iohexol at 50 keV,and 5.6 times that of iohexol at130 keV.We then applied erbium chelate in the in vivo spectral CT imaging of healthy mice and DSSinduced colitis mice.It is found that erbium chelate is rapidly metabolized from the intestinal tract in healthy mice within 12 h due to favorable biocompatibility,while it is enriched and displays brighter signals in the inflammatory site of colon in colitis mice.Specifically,the CT value in the large intestines of colitis mice 12 h after erbium chelate administration is 53.0,which is much higher than that of healthy mice(8.3),showing great potential for sensitive and accurate diagnosis of inflammatory bowel disease.Moreover,compared with the clinically used contrast agent iohexol,erbium chelate shows better spectral CT imaging performance in both healthy and colitis mice at low to high energy settings.Superior CT imaging is also observed in CT26 tumor-bearing mice after administration with erbium chelate in comparison to iohexol.In summary,the small-molecule erbium chelate is expected to be a safe and highperfo rmance co ntrast agent for spectral CT imaging to promote the diagnosis of gastrointestinal diseases. 展开更多
关键词 CT contrast agent Spectral CT Gastrointestinal imaging Rare earths CT imaging
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Echo contrast medium:How the use of contrast echocardiography(ultrasound contrast agents)can improve patient care 认领 引用
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作者 Kevan English 《World Journal of Methodology》 2025年第3期32-37,共6页
Conventional echocardiography can sometimes pose a challenge to diagnosis due to sub-optimal images.Ultrasound contrast agents(UCAs)have been shown to drastically enhance imaging quality,particularly depicting the lef... Conventional echocardiography can sometimes pose a challenge to diagnosis due to sub-optimal images.Ultrasound contrast agents(UCAs)have been shown to drastically enhance imaging quality,particularly depicting the left ventricular endocardial borders.Their use during echocardiography has become a valuable tool in non-invasive diagnostics.UCAs provide higher-quality images that may ultimately reduce the length of hospital stays and improve patient care.The higher cost associated with UCAs in many situations has been an impediment to frequent use.However,when used as an initial diagnostic test,UCA during rest echocardiogram is more cost-effective than the traditional diagnostic approach,which frequently includes multiple tests and imaging studies to make an accurate diagnosis.They can be easily performed across multiple patient settings and provide optimal images that allow clinicians to make sound medical decisions.This consequently allows for better diagnostic accuracies and improvement in patient care. 展开更多
关键词 Ultrasound contrast agents Echocardiography Myocardial perfusion Ultrasound Left ventricle Optison Definity Sonazoid Lumason
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Contrast-enhanced ultrasound using SonoVue mixed with oral gastrointestinal contrast agent to evaluate esophageal hiatal hernia: Report of three cases and a literature review 认领 引用 被引量：10
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作者 Jing-Yu Wang Yan Luo +4 位作者 Wen-Ying Wang Shi-Cheng Zheng Lian He Chun-Yan Xie Li Peng 《World Journal of Clinical Cases》 SCIE 2021年第11期2679-2687,共9页
BACKGROUND Due to a thicker abdominal wall in some patients,ultrasound artifacts from gastrointestinal gas and surrounding tissues can interfere with routine ultrasound examination,precluding its ability to display or... BACKGROUND Due to a thicker abdominal wall in some patients,ultrasound artifacts from gastrointestinal gas and surrounding tissues can interfere with routine ultrasound examination,precluding its ability to display or clearly show the structure of a hernial sac(HS)and thereby diminishing diagnostic performance for esophageal hiatal hernia(EHH).Contrast-enhanced ultrasound(CEUS)imaging using an oral agent mixture allows for clear and intuitive identification of an EHH sac and dynamic observation of esophageal reflux.CASE SUMMARY In this case series,we report three patients with clinically-suspected EHH,including two females and one male with an average age of 67.3±16.4 years.CEUS was administered with an oral agent mixture(microbubble-based SonoVue and gastrointestinal contrast agent)and identified a direct sign of supradiaphragmatic HS(containing the hyperechoic agent)and indirect signs[e.g.,widening of esophageal hiatus,hyperechoic mixture agent continuously or intermittently reflux flowing back and forth from the stomach into the supradiaphragmatic HS,and esophagus-gastric echo ring(i.e.,the“EG”ring)seen above the diaphragm].All three cases received a definitive diagnosis of EHH by esophageal manometry and gastroscopy.Two lesions resolved upon drug treatment and one required surgery.The recurrence rate in follow-up was 0%.The data from these cases suggest that the new non-invasive examination method may greatly improve the diagnosis of EHH.CONCLUSION CEUS with the oral agent mixture can facilitate clear and intuitive identification of HS and dynamic observation of esophageal reflux. 展开更多
关键词 SonoVue Oral gastrointestinal contrast agent Contrast-enhanced ultrasound Gastrointestinal Hiatal hernia Case report
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Self-assembled superparamagnetic nanoparticles as MRI contrast agents — A review 认领 引用 被引量：7
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作者 苏红莹 吴昌强 +1 位作者 李丹阳 艾华 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第12期175-185,共11页
Recent progress of the preparation and applications of superparamagnetic iron oxide（SPIO） clusters as magnetic resonance imaging（MRI） probes is reviewed with regard to their applications in labeling and tracking c... Recent progress of the preparation and applications of superparamagnetic iron oxide（SPIO） clusters as magnetic resonance imaging（MRI） probes is reviewed with regard to their applications in labeling and tracking cells in vivo, in diagnosis of cardiovascular diseases and tumors, and in drug delivery systems. Magnetic nanoparticles（NPs）, especially SPIO nanoparticles, have long been used as MRI contrast agents and as an advantageous nanoplatform for drug delivery,taking advantage of their unique magnetic properties and ability to function at the molecular and cellular levels. Due to advances in nanotechnology, various means to control SPIO NPs＇ size, composition, magnetization and relaxivity have been developed, as well as ways to usefully modify their surface. Recently, self-assembly of SPIO NP clusters in particulate carriers — such as polymeric micelles, vesicles, liposomes, and layer-by-layer（Lb L） capsules — have been widely studied for application as ultrasensitive MRI probes, owing to their remarkably high spin–spin（T2） relaxivity and convenience for further functionalization. 展开更多
关键词 superparamagnetic iron nanoparticles magnetic resonance imaging contrast agent self-assembly
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Non-thermal ablation of rabbit liver VX2 tumor by pulsed high intensity focused ultrasound with ultrasound contrast agent:Pathological characteristics 认领 引用 被引量：6
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作者 Cheng-Wen Zhou Fa-Qi Li +3 位作者 Yan Qin Chun-Mei Liu Xiao-Lin Zheng Zhi-Biao Wang 《World Journal of Gastroenterology》 SCIE CAS 2008年第43期6743-6747,共5页
AIM： To investigate the pathological characteristics of non-thermal damage induced by pulsed high intensity focused ultrasound （PHIFU） combined with ultrasound contrast agent （UCA）, SonoVue （Bracco SpA, Milan, I... AIM： To investigate the pathological characteristics of non-thermal damage induced by pulsed high intensity focused ultrasound （PHIFU） combined with ultrasound contrast agent （UCA）, SonoVue （Bracco SpA, Milan, Italy） in rabbit liver VX2 tumor. METHODS： Liver VX2 tumor models were established in 20 rabbits, which were divided randomly into PHIFU combined with ultrasound contrast agent group （PHIFU ＋ UCA group） and sham group. In the PHIFU ＋ UCA group, 0.2 mL of SonoVue was injected intravenously into the tumor, followed by ultrasound exposure of Isp 5900 W/cm^2. The rabbits were sacrificed one day after ultrasound exposure. Specimens of the exposed tumor tissues were obtained and observed pathologically under light microscope and transmission electron microscope. The remaining tumor tissues were sent for 2,3,5-Triphenyltetrazolium chloride （TTC） staining. RESULTS： Before Trc staining, tumor tissues in both the sham and the PHIFU ＋ UCA groups resembled gray fish meat, After TIC staining, the tumor tissues were uniformly stained red, with a clear boundary between tumor tissue and normal tissue, Histological examination showed signs of tumor cell injury in PHIFU ＋ UCA group, with cytoplasmic vacuoles of various sizes, chromatin margination and karyopyknosis. Electron microscopic examination revealed tumor cell volume reduction, karyopyknosis, chromatin margination, intercellular space widening, the presence of high electro＇n-density apoptotic bodies and vacuoles in cytoplasm. CONCLUSION： The non-thermal effects of PHIFU combined with UCA can be used to ablate rabbit liver VX2 tumors. 展开更多
关键词 Pulsed high intensity focused ultrasound Ultrasound contrast agent Non-thermal effects Rabbitliver VX2 tumors Histopathology
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Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent 认领 引用 被引量：5
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作者 Dan Wu Xinxin Zhang +1 位作者 Jian Rong Huabei Jiang 《Journal of Innovative Optical Health Sciences》 SCIE EI 2019年第3期41-54,共14页
In this study,we developed a novel photoacoustic imaging technique based on poly(ethyleneglycol)-coated(PEGylated)gold nanorods(PEG-GNRs)(as the contrast agent)combined with traditional Chinese medicine(TCM)acupunctur... In this study,we developed a novel photoacoustic imaging technique based on poly(ethyleneglycol)-coated(PEGylated)gold nanorods(PEG-GNRs)(as the contrast agent)combined with traditional Chinese medicine(TCM)acupuncture(as the auxiliary method)for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo.This study takes advantage of the strong near-infrared absorption(peak at700 nm)of GNRs and the ability to adjust the hemodynamics of acupuncture.Experimental results show that photoacoustic tomography(PAT)successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint(ST36)both individually and combined.The quantitative measurement of contrast enhancement indicates that the composite contrast agents(integration of acupuncture and GNRs)would greatly enhance the photoacoustic imaging contrast.The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture. 展开更多
关键词 Photoacoustic tomography acupuncture contrast agent nanorods Zusanli acupoint
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FEASIBILITY STUDY OF AN ULTRASOUND CONTRAST AGENT(LEVOVIST) IN COLOR DOPPLER IMAGING OF LIVER NEOPLASMS 认领 引用 被引量：6
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作者 姜玉新 戴晴 +4 位作者 刘吉斌 张缙熙 常欣 蔡胜 谭莉 《Chinese Medical Sciences Journal》 CAS 1999年第3期167-169,共3页
The purpose of this study was to determine the efficacy of using an ultrasound contrast agent(levovist)to enhance the color Doppler imaging of liver neoplasms.Thirty patients with hepatic tumors were enrolled in this ... The purpose of this study was to determine the efficacy of using an ultrasound contrast agent(levovist)to enhance the color Doppler imaging of liver neoplasms.Thirty patients with hepatic tumors were enrolled in this study.After intravenous administration of levovist,the color Doppler signals of normal hepatic vessels were enhanced.In various hepatic tumors,the different patterns of tumor vascularity were observed,which had not been demonstrated in conventional non contrast color Doppler imaging.In 11 of 16 patients with hepatocarcinoma,additional color Doppler signals were observed in the central part of the tumors.On the contrary,3 patients with metastatic liver lesions the enhanced color Doppler signals appear only at the peripheral of tumors.A typical rim like color enhancement was seen in 2 of the 3 cases.In six patients with hepatic hemangiomas contrast enhanced color Doppler imaging demonstrated the blood vessels at the margin of the neoplasms.Contrast enhanced color Doppler imaging improves the visualization of the hepatic neoplasm vascularity.This technique holds great promise for detecting small liver tumors and differentiating hepatic neoplasms. 展开更多
关键词 ultrasound contrast agent color Doppler imaging liver neoplasms
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Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study 认领 引用 被引量：3
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作者 Zhi-yuan XIA Christine BRUGUIER +3 位作者 Fabrice DEDOUIT Silke GRABHERR Marc AUGSBURGER Bei-bei LIU 《Current Medical Science》 SCIE CAS 2020年第4期786-794,共9页
Summary:Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography(PMMRA).However,in this emerging field,the number of suitable kinds of liquid is still very lim... Summary:Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography(PMMRA).However,in this emerging field,the number of suitable kinds of liquid is still very limited.The objective of this research is to compare MR images of oleic acid(OA)with paraffin oil(PO)in vitro and in ex situ animal hearts,in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA.In vitro,OA,PO and water(control)were introduced into three tubes separately and T,weighted-spin echo(Tw SE)and T2w-SE images were acquired on a 1.5T MR scanner.In the second experiment,0A and PO were injected into left coronary artery(LCA)and left ventricle(LV)of ex situ bovine hearts and their Tw-SE,Tzw-SE,Tw-multipoint Dixon(Tjw-mDixon)and 3DT2w-mDixon images were acquired.The overall results indicate that OA may have a potential to be used as a dual(T and T2 based)contrast agent for PMMRA when proper sequence parameters are utilized.However,as the pilot study was based on limited number of animal hearts,more researches using OA in cadavers are needed to validate our findings. 展开更多
关键词 postmortem magnetic resonance angiography perfusate contrast agent oleic acid paraffin oil heart
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Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential multimodal imaging contrast agent 认领 引用 被引量：1
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作者 Yongxiu Li Feng Guo +4 位作者 Siwei Wei Duofu Li Jun Zhang Kai Xu Dongping Li 《Journal of Rare Earths》 SCIE EI CAS CSCD 2024年第2期278-285,I0002,共8页
The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination chemistry.Benefiting from the unique luminescent and magnetic properties of lanthanide ions,the potential... The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination chemistry.Benefiting from the unique luminescent and magnetic properties of lanthanide ions,the potential applications of lanthanide-organic cages in biological imaging applications are promising,but only a few corresponding explorations have been reported.He rein,we introduced a series of lanthanide tetrahedral cages,(EunGd4-nL4)(sol)_8(n=0,1,2,3 and 4,where L=(4,4',4"-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine,and sol=dimethyl sulfoxide and methanol),with potential applications in biological imaging.Given the good luminescent and magnetic properties of Eu3+ and Gd3+ ions,Eu4L4 and Gd4L4 complexes show a high luminescence quantum yield of 29% in DMSO and large longitudinal relaxivity(r1) of 11.4(mmol/L)-1/s at 0.5 T in water containing 1 vol% DMSO,respectively.The heterobimetallic Eu-Gd complexes achieve a dual imaging mode by combining luminescent and magnetic centers in one cage.When the Gd:Eu ratio increases from 1:3 to 3:1,the r1 values increases from 5.33 to 8.64(mmoI/L)-1/s,higher than that of commercial contrast agent Gd-DOTA(3.23(mmol/L)-1/s).Owing to their low toxicity and good cell imaging ability toward ECA 109 cells,the selfassembled Eu-Gd heterobimetallic tetrahedral cages could be potential candidates for the multimodal imaging contrast agent. 展开更多
关键词 Lanthanide organic cage Luminescence Cell imaging Contrast agents Rare earths
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PREPARATION OF POLYELECTROLYTE MULTILAYER COATED MICROBUBBLES FOR USE AS ULTRASOUND CONTRAST AGENT 认领 引用 被引量：1
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作者 Zhan-wen Xing Heng-te Ke +3 位作者 Shao-qin Liu Zhi-fei Dai Jin-rui Wang Ji-bin Liu 《Chinese Medical Sciences Journal》 CAS 2008年第2期103-107,共5页
Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchym... Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchyma. Methods Perfluorocarbon （PFC）-containing microbubbles （ST68-PFC） were prepared by sonication based on suffactant （ Span 60 and Tween 80）. Subsequently, the resulting ST68-PFC microbubbles were coated using oppositely charged polyelectrolytes by microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement effects in ultrasonic imaging on normal rabbit＇s liver parenchyma were assessed. Results The obtained microbubbles exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles. In vivo experiment showed that polyelectrolyte multilayer film coated UCA effectively enhanced the imaging of rabbit＇s liver parenchyma. Conclusions The novel microbubbles UCA coated with polyelectrolyte multilayer, when enabled more function, has no obvious difference in enhancement effects compared with the pre-modified microbubbles. The polymers with chemically active groups （ such as amino group and carboxyl group） can be used as the outermost layer for attachment of targeting ligands onto microbubbles, allowing selective targeting of the microbubbles to combine with desired sites. 展开更多
关键词 microbubbles ultrasound contrast agent layer-by-layer self-assembly technique polyelectrolyte
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Study on Multi-density Contrast Agent Fillers of Duct Casting Based on CT Three-Dimensional Reconstruction 认领 引用 被引量：6
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作者 黄海龙 陈进军 +2 位作者 王瑜 陈小宇 龚达聪 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2017年第2期300-306,共7页
The three-dimensional visualization model of human body duct is based on virtual anatomical structure reconstruction with duct angiography,which realizes virtual model transferred from two-dimensional,planar and stati... The three-dimensional visualization model of human body duct is based on virtual anatomical structure reconstruction with duct angiography,which realizes virtual model transferred from two-dimensional,planar and static images into three-dimensional,stereoscopic and dynamic ones repectively.In recent years,the multi-duct segmentation and division of the same specimen（or organ） is the focus of attention shared by surgeons and clinical anatomists.On the basis of 4.22 g/cm3 body bone density,this study has screened out metal oxide contract agent with different density for infusion and modeling,as well as compared and analyzed the effects of three-dimensional image of CT virtual bronchoscopy（CTVB）,three-dimensional image of CT maximum intensity projection and three-dimensional model.This experiment result showed synchronously infusing multi-duct of same specimen（or organ） with contrast agent in different densities could reconstruct three-dimensional models of all ducts once only and adjust threshold to develop single or multiple ducts.It was easier to segment and observe the duct structure,anastomosis,directions and crossing in different parts,which was beyond comparison with three-dimensional image of CTVB.Although the existing three-dimensional duct reconstruction techniques still cannot be applied in living bodies temporarily,this study focused on a creative design of ducts segmentation in different density,which proposed a new experimental idea for developing multi-duct three-dimensional model in living body in the future.It will play a significant role in disease diagnosis and individual design in surgical treatment program.Therefore,this study observes the three-dimensional status of human duct with the application of contrast agent fillers in different density,combined with three-dimensional reconstruction technology.It provides an innovative idea and method for constructing three-dimensional model of digital multi-duct specimen,and the ultimate goal is to develop the digitized virtual human and precise medical treatment better and faster. 展开更多
关键词 bronchi of pig lung three-dimensional reconstruction contrast agent density difference duct casting
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Clinical applications,safety profiles,and future developments of contrast agents in modern radiology:A comprehensive review 认领 引用 被引量：2
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作者 Reabal Najjar 《iRADIOLOGY》 2024年第5期430-468,共39页
Contrast agents have transformed the field of medical imaging,significantly enhancing the visualisation of internal structures and improving diagnostic accuracy across X-rays,computed tomography,magnetic resonance ima... Contrast agents have transformed the field of medical imaging,significantly enhancing the visualisation of internal structures and improving diagnostic accuracy across X-rays,computed tomography,magnetic resonance imaging(MRI),and ultrasound.This review explores the historical development,physicochemical properties,and mechanisms of action of iodinated,gadolinium-based,barium sulfate,microbubble,and nanoparticle contrast agents.It highlights key advancements,including the transition from high-osmolar to low-and iso-osmolar iodinated agents,the integration of gado-linium in MRI,and the innovative use of microbubbles and nanoparticles.The review critically examines the safety profiles and adverse reactions of these contrast agents,categorising them into hypersensitivity and physiological reactions.It outlines risk factors,common misconceptions,and management strategies for adverse reactions,emphasising the importance of personalised approaches in clinical practice.Additionally,it delves into broader implications,including ethical considerations,environmental impact,and global accessibility of contrast media.The review also discusses technological advancements such as targeted contrast agents and the integration of artificial intelligence to optimise contrast dosage.By synthesising current knowledge and emerging trends,this review underscores the pivotal role of contrast agents in advancing medical imaging.It aims to equip clinicians,researchers,and policymakers with a thorough understanding to enhance diagnostic efficacy,ensure patient safety,and address ethical and environmental challenges,thereby informing future innovations and regulatory frameworks to promote equitable access to advanced imaging technologies globally. 展开更多
关键词 computed tomography contrast agents magnetic resonance ultrasound X-ray
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Nonlinear response of ultrasound contrast agent microbubbles:From fundamentals to applications 认领 引用
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作者 滕旭东 郭霞生 +1 位作者 屠娟 章东 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第12期49-56,共8页
Modelling and biomedical applications of ultrasound contrast agent （UCA） microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including （i） ... Modelling and biomedical applications of ultrasound contrast agent （UCA） microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including （i） the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; （ii） a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; （iii） the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and （iv） the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures. 展开更多
关键词 ultrasound contrast agents microbubbles nonlinear response inertial cavitation DNA transfec- tion
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Mesoporous MnSiO3@Fe3O4@C Nanoparticle as p H-responsive T1-T2* Dual-modal Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis 认领 引用
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作者 Bei-chen Duan Peng-ping Xu +1 位作者 Zhen Guo Qian-wang Chen 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2019年第3期391-398,I0002,I0003-I0012,共8页
Mesoporous structured MnSiO3@Fe3O4@C nanoparticles(NPs)were prepared via a facile and efficient strategy,with negligible cytotoxicity and minor side efforts.The as-prepared MnSiO3@Fe3O4@C NPs hold great potential in s... Mesoporous structured MnSiO3@Fe3O4@C nanoparticles(NPs)were prepared via a facile and efficient strategy,with negligible cytotoxicity and minor side efforts.The as-prepared MnSiO3@Fe3O4@C NPs hold great potential in serving as pH-responsive T1-T2^*dual-modal magnetic resonance(MR)imaging contrast agents.The released Mn^2+shortened T1 relaxation time,meanwhile the superparamagnetic Fe3O4 enhanced T2 contrast imaging.The release rate of Mn ions reaches 31.66%under the condition of pH=5.0,which is similar to tumor microenvironment and organelles.Cytotoxicity assays show that MnSiO3@Fe3O4@C NPs have minor toxicity,even at high concentrations.After intravenous injection of MnSiO3@Fe3O4@C NPs,a rapid contrast enhancement in tumors was achieved with a significant enhancement of 132%after 24 h of the administration.Moreover,a significant decreasement of 53.8%was witnessed in T2 MR imaging signal.It demonstrated that MnSiO3@Fe3O4@C NPs can act as both positive and negative MR imaging contrast agents.Besides,owing to the pH-responsive degradation of mesoporous MnSiO3,MnSiO3@Fe3O4@C NPs can also be used as potential drug systems for cancer theranostics. 展开更多
关键词 Magnetic resonance imaging MnSiO3@Fe3O4@C Dual-modal Contrast agent
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