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Epigenetic mechanisms of heterosis in tea plants:insights into m6A RNA methylation and miRNA-mediated regulation 认领 引用 被引量：2
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作者 Xiansheng Liao Mengting Tang +4 位作者 Wenlong Lei Hongzheng Lin Shan Jin Pengjie Wang Naixing Ye 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第6期1479-1491,共13页
Heterosis is fundamental to modern tea breeding practices and is widely used in tea production.However,the epigenetic regulatory mechanisms underlying heterosis in tea plants remain relatively unknown.In this study,we... Heterosis is fundamental to modern tea breeding practices and is widely used in tea production.However,the epigenetic regulatory mechanisms underlying heterosis in tea plants remain relatively unknown.In this study,we integrated transcriptome,RNA methylation,and miRNA profile information to understand the epigenetic basis of heterosis in tea plants.We found that although m6A methylation modifications and miRNAs are highly conserved in tea plants,a significant number of differentially methylated and differentially expressed genes and differentially expressed miRNAs showed non-additive genetic effects in the hybrid.This non-additive expression is closely related to the synthesis of secondary metabolites and plant stress responses,implying that the regulation of these genes plays a key role in enhancing the quality and stress tolerance of hybrids.Through comprehensive analyses of the transcriptome,m6A methylation modifications,and miRNAs,we established a multi-level regulatory network,revealing the molecular mechanisms by which m6A methylation modifications and miRNAs drive heterosis in tea plants from the transcriptional to the post-transcriptional regulatory level.This multi-level regulatory network not only deepens our understanding of tea plant heterosis but also provides novel insights for further studies on the role of m6A methylation and miRNAs in tea plant heterosis. 展开更多
关键词 Camellia sinensis Heterosis Epigenetic Post-transcriptional regulation Multi-level regulatory network
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Neural Network-Based Switching Output Regulation Control for High-Speed Nano-Positioning Stages 认领 引用 被引量：1
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作者 Hongwei Sun Ning Xing +4 位作者 Jiayu Zou Yuqi Rong Yang Shi Han Ding Hai-Tao Zhang 《Engineering》 SCIE EI CSCD 2026年第2期227-235,共9页
This study establishes a high-speed nano-positioning stage composed of a symmetrically driven structure with multiple parallel-bonded thin piezoelectric ceramic layers capable of performing micro-or nanoscale manipula... This study establishes a high-speed nano-positioning stage composed of a symmetrically driven structure with multiple parallel-bonded thin piezoelectric ceramic layers capable of performing micro-or nanoscale manipulations.Accordingly,a neural-network-based switching output regulation controller(NNSORC)was developed to compensate for the associated hysteresis nonlinearity.To address the challenges of slow floating-point computation speeds and low compilation efficiency,a closed-loop control system with a field-programmable gate array–central processing unit(FPGA–CPU)dual-layer data-processing framework was developed.A feedback linearization method was designed to linearize the hysteresis nonlinearity of the framework,resulting in a switching-tracking error system.With the assistance of Lyapunov theory and an average dwell time technique,sufficient conditions were derived to ensure the asymptotic stability of the NN-SORC governing closed-loop system using the switching reference signals often encountered in realistic micro-ano-scale detection and manufacturing processes.Finally,extensive comparative experiments were conducted to verify the effectiveness and superiority of the proposed NN-SORC scheme. 展开更多
关键词 High-speed nano-positioning stage Switched system Intelligent control Output regulation control
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Animal research in the UK:Regulation,implementation,welfare and development of new approach methodologies 认领 引用
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作者 Ewan St.John Smith James Bussell +4 位作者 Maggie Gentry Elliot Lilley Cathy Merry Judy MacArthur Clark William Reynolds 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第5期1056-1062,共7页
Use of animals in biomedical research is still considered essential by many in aca-demia,industry and regulatory authorities.Therefore,it is important that legal,gov-ernance and welfare procedures are in place to ensu... Use of animals in biomedical research is still considered essential by many in aca-demia,industry and regulatory authorities.Therefore,it is important that legal,gov-ernance and welfare procedures are in place to ensure that only necessary procedures using animals are carried out and that this occurs within a framework with animal welfare at its core.Animal research in the United Kingdom is conducted under the Animals(Scientific Procedures)Act 1986 and animal research in the United Kingdom has long been seen as a flag bearer for high quality-high welfare research.An example of the leading role taken in supporting animal welfare in research was establishment of the National Centre for the Replacement,Refinement and Reduction of Animals in Research(NC3Rs)to support reducing the scale and impact of animal research.Here,we provide an overview of governance and licensing procedures of animal research in the United Kingdom,coupled with explanations of how excellent welfare underpins high quality research,and examine the development of new approach methodologies. 展开更多
关键词 3Rs New approach methodologies Regulation Welfare
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Epigenetic regulation of fruit anthocyanin biosynthesis in horticultural crops 认领 引用
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作者 Yan Wang Feng Zhang +4 位作者 Dongxue Ren Kuoxin Zeng Yiqing Sun Niuniu Wu Zhihong Zhang 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第3期529-538,共10页
Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigeneti... Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation. 展开更多
关键词 Anthocyanins Horticultural plants Epigenetic regulation Fruit quality
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Copper ion-antibiotic complexation inhibits photochemical transformation of fluoroquinolones via electron redistribution and reactivity regulation 认领 引用
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作者 Bo Gong Chang Xu +4 位作者 Shan Zhao Xiao-Min Sun Shu-Guang Wang Xian-Zheng Yuan Chao Song 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期584-592,共9页
The photochemical transformation of fluoroquinolones(FQs) represents a crucial environmental phenomenon eliciting growing concern. Nevertheless, the impact and mechanisms of ubiquitously coexisting copper ions, i.e.,... The photochemical transformation of fluoroquinolones(FQs) represents a crucial environmental phenomenon eliciting growing concern. Nevertheless, the impact and mechanisms of ubiquitously coexisting copper ions, i.e.,Cu(Ⅱ), remain elusive. Here, the role of Cu(Ⅱ) in the photochemical transformation of FQs was systematically investigated via experimental characterizations and theoretical simulations. Cu(Ⅱ) markedly inhibited the photolysis of levofloxacin(LEV), a representative FQs model, from 0.0078 to 0.0040 min-1 after a 100-min irradiation under simulated sunlight with the molar ratio of Cu(Ⅱ): LEV at 1:1. The micro-level mechanisms were explored, including the ligand-to-metal charge transfer in complexation, modifications to reactive sites and activities with various reactive species, and higher hole-electron separation extents. In addition, the triplet excited state, singlet oxygen, and hydroxyl radical in LEV and LEV-Cu(Ⅱ) with 1:1 molar ratio played pivotal roles in the transformation, contributing 20.77 %/20.02 %, 13.87 %/14.59 %, and 7.96 %/4.68 %, respectively. Furthermore, considering more FQs models, the inhibition of Cu(Ⅱ) on the transformation was found to universally exist in ciprofloxacin, enoxacin, enrofloxacin, norfloxacin, ofloxacin and pefloxacin, and their multiple molecular descriptors were changed with a same tendency. This work provides a comprehensive understanding of the transformation of antibiotics within complex aqueous matrices, contributing to further estimation of antibiotics removal and ecological risks. 展开更多
关键词 Fluoroquinolones Photochemical transformation Copper complexation Reactivity regulation Molecular mechanism
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A transformable DNA Nano-windmill for the activation and regulation of the heterodimerization receptors across RTK families 认领 引用
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作者 Kun Liu Junjun Lu +7 位作者 Jincheng Lin Yulin Cong Xiongfeng Luo Zihong Huang Tianyi Zhang Miao Wang Zhiyong Xie Hao Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期556-559,共4页
Heterodimerization of receptor tyrosine kinases(RTKs)plays unique roles in cell signaling and functions.However,engineering heterodimerization of multiple receptors remains largely unexplored.Herein,we developed an ap... Heterodimerization of receptor tyrosine kinases(RTKs)plays unique roles in cell signaling and functions.However,engineering heterodimerization of multiple receptors remains largely unexplored.Herein,we developed an aptamer-based DNA Nano-windmill(TA3)to regulate heterodimerization of three different RTK families,simultaneously activating fibroblast growth factor receptor 1(FGFR1),hepatocyte growth factor receptor(Met)and epidermal growth factor receptor(EGFR)signaling.It is the first DNA Nanowindmill that activates heterodimerization of FGFR1,Met and EGFR,leading to the down-stream signals transduction,such as the phosphorylation of protein kinase B(Akt)and extracellular regulated protein kinases(Erk),inducing the cell migration and proliferation.We further designed transformable DNA Nanowindmill(TMA)that can convert DNA Nano-windmill into DNA Nano-kite using complementary strands or small molecules to reduce the activation of specific receptor.We believe that the DNA Nano-windmill for heterodimerization of different RTK families have potential applications in biomedicine fields. 展开更多
关键词 DNA Nano-windmill Heterodimerization Receptor tyrosine kinases Aptamer Cell regulation
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Alkalinity regulation of bauxite residue mediated by Penicillium oxalicum:Insights into carbon components dynamics 认领 引用
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作者 Shengguo Xue Ziying Zhang +5 位作者 Xinfeng Qin Yifan Jiang Zhiqiang Zhao Mingli Wang Jinglan Ma Feng Zhu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期442-451,共10页
Microbially-driven alkaline neutralization during soil formation in bauxite residue is a promising technology toward sustainable management of alkaline solid-waste landscapes worldwide.However,our knowledge regarding ... Microbially-driven alkaline neutralization during soil formation in bauxite residue is a promising technology toward sustainable management of alkaline solid-waste landscapes worldwide.However,our knowledge regarding the impacts of microorganisms on the organic components dynamics involved in alkalinity regulation remains rather limited.In this study,we performed water-phase and solid-phase microcosm experiments using Penicillium oxalicum and sugarcane bagasse with gradient addition amount.Multi-spectroscopic techniques and metabolomic analysis were employed to investigate the combined effects of alkaline stabilization and carbon components dynamics in bauxite residue.An addition of 5‰of sugarcane bagasse was appropriate to reduce the pH of bauxite residue from 10.16 to30%.Spectroscopic analysis verified that sugarcane bagasse predominantly formed connections with humic substances,establishing zones rich in carbon containing fulvic and humic acids,which promoted the bio-production of lowmolecular-weight-organic acids.Metabolomic analysis identified 631 compounds,with 126 associated to carbon metabolism.Notably,tricarboxylic acid cycle(TCA)pathway involving acetate and oxalate were significantly upregulated following the combined application.Mantel-test analysis further showed positive correlations between 5-hydroxyindoleacetic acid and 5-phosphonooxy-L-lysine and alkalinity regulation,proving that the combined application regulated alkalinity by improving amino acid metabolism and carbon skeleton reutilization.Overall,our findings highlighted the metabolic mechanisms involved in alkalinity regulation during soil formation process mediated by P.oxalicum and provided an optimized solution for microbially-driven alkaline regulation within bauxite residue. 展开更多
关键词 Bauxite residue Penicillium oxalicum Carbon component Metabolomics Alkaline regulation Soilization
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Real-time regulation of zinc deposition/stripping by self-assembled molecule brush targeting proton for highly reversible Zn-ion battery 认领 引用
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作者 Zeping Liu Lijie Wang +5 位作者 Zeren Zhou Qixian Zhang Yixiang Zhang Wei Han Qiaoyan Lin Lishuang Fan 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第2期541-549,I0012,共9页
Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the ad... Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the adsorption layer and the ambiguous mechanisms of action.In this study,a highly stable Vani molecular brush additive was designed.The additive effectively inhibits H2 generation by targeting and anchoring H+in the inner Helmholtz layer,and reduces the water activity by constructing an enhanced hydrogen bonding network through the interaction with water molecules,thus inhibiting the parasitic side reactions on the zinc anode.In addition,the dynamic interfacial molecular layer can regulate and buffer the interfacial Zn2+for highly reversible plating/stripping.Experiments show that the symmetric cell cycle life is as long as 3760 h at a Vani content of only 2×10-3 g L-1 with a current density of5 mA cm-2.The cycle life of the Zn‖MnO2 and Zn‖Zn0.58V2O5 H2O full battery is significantly improved.This study deepens the understanding of the working mechanism of the zinc electrode interface and provides new ideas for non-sacrififcial trace additive design. 展开更多
关键词 Zinc ion battery Zinc Anode Dynamic regulation Molecule brush Proton
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Fluorine-induced dual regulation of Co(OH)2 active sites and reactant adsorption behavior for boosted 5-hydroxymethylfurfural electrooxidation performance 认领 引用
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作者 Qin Hu Lijin Yan +7 位作者 Lingwei Feng Mengyuan Ren Chao Juan Chao Huang Siwei Li Alin Cao Zhe Liu Dan Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第7期543-555,I0014,共13页
Electrooxidation of 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA)is pivotal for upgrading biomass to high-value bio-based monomers.However,this process is severely constrained by two critical challen... Electrooxidation of 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA)is pivotal for upgrading biomass to high-value bio-based monomers.However,this process is severely constrained by two critical challenges:insufficient catalytic active sites and the intrinsic competitive adsorption between HMF and OH-,which collectively restrict reaction kinetics and impede industrial scalability.Herein,we report a fluoride-assisted anodic electric field activation strategy that enables one-step synergistic integration of F-doping into the Co(OH)2 lattice and electrochemical activation.This rational design yields F-doped Co(OH)2/NF electrocatalysts with abundant Co3+/Ni3+active species.The optimized catalyst exhibits a markedly enhanced HMF oxidation reaction(HMFOR)current density of 105 mA cm-2at 1.5 V vs.RHE,corresponding to a 170%enhancement compared with pristine Co(OH)2/NF,along with high 95%FDCA selectivity and excellent stability.Mechanistic investigations reveal that F doping exerts a dual regulatory effect:it not only facilitates the in-situ generation of reactive Co3+/Ni3+active sites but also synergistically modulates the adsorption behavior of HMF and OH-.This synergism effectively mitigates adsorption competition and accelerates the rate-determining steps of HMFOR.Collectively,this work provides a new paradigm for the rational design of high-efficiency electrocatalysts via the synergistic regulation of active sites and adsorption properties,thereby laying a solid foundation for advancing the industrialization of sustainable biomass valorization. 展开更多
关键词 Electrocatalytic oxidation 5-Hydroxymethylfurfural Fluoride doping Adsorption regulation Biomass valorization
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Sweet genomes provide colorful life:a review on molecularly tagged genes and biological regulation of breeding characters in watermelon and melon 认领 引用
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作者 Shi Liu Jiayi Han +9 位作者 Hongyu Shi Cheng Rui Xufeng Fang Shuang Pei Cheng Yao Xuezheng Wang Zicheng Zhu Hongyu Liu Peng Gao Feishi Luan 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期781-798,共18页
Watermelon and melon are important members of the Cucurbitaceae family,offering high economic benefit and nutritional value.With the release and ongoing refinement of the watermelon and melon genomes,many target genes... Watermelon and melon are important members of the Cucurbitaceae family,offering high economic benefit and nutritional value.With the release and ongoing refinement of the watermelon and melon genomes,many target genes(or loci)for further biology regulation exploration and molecular breeding,have been identified.Herein,we describe recent progress in genetic mapping and molecular regulation mechanisms for fruit quality,fruit development,plant morphogenesis,and plant disease resistance.We further outline future research priorities and breeding frameworks for watermelon and melon.This review delineates molecular regulators of fruit and plant development,offering a framework to explore homologous mechanisms in other Cucurbitaceae members. 展开更多
关键词 Watermelon Melon Genetic mapping Biology regulation Molecular breeding
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Solvation-interphase synergistic regulation empowering high-temperature and fast-charging lithium metal batteries 认领 引用
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作者 Liu Yang Haohan Chen +7 位作者 Yajie Hu Jinyu Tian Yupeng Feng Yuanjian Li Meng Yao Fei Li Jianping Long Anjun Hu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第1期444-452,I0010,共9页
Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditio... Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li+solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li3N-Li2S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO2//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering. 展开更多
关键词 Lithium-metal batteries Electrolyte additives Solvation structure Interphase regulation Pouch cells
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Amphiphilic Hyaluronic Acids Enhance Sanshool's Efficacy against Skin Photodamage via Stability Improvement and Cell Cycle Regulation 认领 引用
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作者 Yi Yang Jun-Mei Song +5 位作者 Tian-You Wang Shu-Wei Wu Yu-Hang Zhou Zhi-Peng Gu Ling-Hong Guo Xian Jiang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第7期2370-2384,共15页
Sanshool is a promising skin photoprotective agent with strong UV absorption and great antioxidative activity.However,it faces challenges including poor stability,skin penetration-associated systemic toxicity,and effi... Sanshool is a promising skin photoprotective agent with strong UV absorption and great antioxidative activity.However,it faces challenges including poor stability,skin penetration-associated systemic toxicity,and efficacy loss upon chemical modification.To address these issues,amphiphilic hyaluronic acids(HHA)were synthesized and self-assembled to integrate with sanshool via hydrophobic interactions,significantly boosting its photostability by 24%and enhancing its antioxidative activity.In HaCaT cells,HHA-sanshool nanoparticles(NPs)reduced UVBinduced reactive oxygen species,decreased cell apoptosis,and lowered G2/M phase arrest from 42%to approximately 31%(close to the normal level),while also inhibiting excessive autophagy.Moreover,in a mouse model,HHA-sanshool NPs alleviated UVB-induced skin damage,reducing skin thickening by up to 50%and mitigating erythema,protected collagen/elastic fibers,and suppressed proinflammatory factor,with no dermal penetration in vivo.This strategy provides a simple,efficient and safe platform for natural active molecular clinical translation in skin photoprotection. 展开更多
关键词 Hyaluronic acid Sanshool Nanoplatform Stability improvement Cell cycle regulation
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Self-recovery regulation method of rotor unbalance vibration based on GWO-ALQR 认领 引用
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作者 Jiaqiao Lu Ruijie Feng +3 位作者 Xin Pan Meng Zhang Weilong Ma Jinji Gao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第1期115-124,共10页
Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-... Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-line self-recovery of unbalanced vibration faults in a rotor system,a self-recovery regulation method based on the grey wolf optimization-adaptive linear quadratic regulator(GWO-ALQR)is proposed.First,a self-recovery regulation system for unbalanced vibrations was constructed,with the state-space equation of the control system obtained and discretized based on the dynamic equation of the rotor-bearing system.Subsequently,a self-recovery regulation method for unbalanced vi-brations based on GWO-ALQR was designed based on the state-space equation.In this method,the parameters of the control system are optimized using grey wolf optimization(GwO),with the working conditions identified on-line.The optimization parameters were selected independently,while the control commands were generated through a linear quadratic regulator(LQR)to control the action of the actuator to achieve self-recovery of the unbalanced vibration.The experimental results indicate that the unbalanced vibration of the rotor system can be restrained below the expected vibration threshold by the self-recovery regulation system based on GWO-ALQR and the final vibration suppression effect can exceed 70%. 展开更多
关键词 Unbalanced vibration Self-recovery regulation Vibration control State-space equation GWO LQR
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Transcriptional,epigenetic,and post-translational regulation of plant autophagy 认领 引用
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作者 Yao Wang Chao-Ying Liu +3 位作者 Liang Chen Si-Hai Guo Shi Xiao Hua Qi 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第7期1180-1193,共14页
Autophagy is a highly conserved intracellular recycling process in eukaryotes that delivers cellular components to the lysosome or vacuole for degradation,thereby maintaining intracellular homeostasis.Acting as a qual... Autophagy is a highly conserved intracellular recycling process in eukaryotes that delivers cellular components to the lysosome or vacuole for degradation,thereby maintaining intracellular homeostasis.Acting as a quality control system,autophagy plays a pivotal role in plant growth,development,and adaptation to environmental challenges.The regulation of autophagy under stress conditions involves multi-layered mechanisms,including transcriptional,epigenetic,and post-translational controls.Transcription factors from families such as WRKY,NO APICAL MERISTEM/ARABIDOPSIS TRANSCRIPTION ACTIVATION FACTOR/CUP-SHAPED COTYLEDON(NAC),and basic leucine zipper(bZIP)directly bind to the promoters of autophagy-related(ATG)genes,thereby integrating stress-responsive signal pathways to orchestrate autophagic activity dynamically.Epigenetic modifications,including histone modifications,DNA methylation,N6-methyladenosine(m6A)methylation,and microRNA-mediated silencing,further fine-tune expression of ATG genes in response to changing environments.At the post-translational level,modifications such as phosphorylation,ubiquitination,acetylation,persulfidation,and S-nitrosylation serve as rapid regulatory switches that modulate autophagosome formation under stress.This review summarizes recent advances in elucidating these regulatory layers,highlighting how these regulators collectively modulate autophagy to improve plant tolerance to environmental cues.Unraveling these mechanisms will expand our understanding of the autophagy regulatory network in plants and provide potential strategies for improving stress tolerance in crops. 展开更多
关键词 Autophagy Environmental challenges Transcription factors Epigenetic regulation Post-translational modifications Regulatory network
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Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment 认领 引用
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作者 Hui-Xin Li Rui-Ying Wu +3 位作者 Xin-Tong Mao Xiao-Rui Zhou Kai Hao Hua-Yu Tian 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第8期2427-2452,I0008,共26页
Cancer immunotherapy,which harnesses the host immune system to combat cancer,has advanced into preclinical and clinical trials.However,the tumor microenvironment(TME)usually promotes tumor angiogenesis and induces imm... Cancer immunotherapy,which harnesses the host immune system to combat cancer,has advanced into preclinical and clinical trials.However,the tumor microenvironment(TME)usually promotes tumor angiogenesis and induces immune tolerance.Recently,polymeric nanomedicines with comprehensive regulation of the TME have attracted research interest.Compared with others,polymeric nanomedicines have outstanding characteristics,including facile preparation,improved tumor penetration,longer blood circulation,and better bioavailability.In particular,polymeric nanomedicines hold great potential for integrating combined treatments and imaging methods to concurrently modulate and trace the functional processes of multiple immune cells.This review summarizes the advances in polymeric nanomedicine-based strategies for TME regulation,including the regulation of TME stromal cells,the immune microenvironment matrix,and vasculature.Furthermore,the development of comprehensive polymeric nanomedicine-based theragnostic platforms integrated with imaging segments is briefly introduced. 展开更多
关键词 Polymeric nanomedicines TME regulation Cocktail cancer immunotherapy Theranostic nanoplatforms
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Review on the biosynthesis,regulation,multifaceted biological activities,and applications of volatile organic compounds 认领 引用
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作者 Xialei Liu Xuewei Zhou +1 位作者 Yuyu Zhang Jialiang Xu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1596-1614,共19页
The role of volatile organic compounds(VOCs)in food,medicine,and agriculture is gaining significant attention.This comprehensive review delves into the biosynthetic pathways,regulatory and bioactivity profiles,and pro... The role of volatile organic compounds(VOCs)in food,medicine,and agriculture is gaining significant attention.This comprehensive review delves into the biosynthetic pathways,regulatory and bioactivity profiles,and prospects of VOCs,encompassing a spectrum from volatile terpenoids to phenolics,aldehydes,ketones,and acids.We commence with an exploration of the diverse biosynthetic routes of VOCs,focusing on the methylerythritol phosphate,mevalonate,and phenylpropanoid pathways and elucidating the key enzymes and intermediates.Subsequently,we examine the bioactivity of VOCs,highlighting their antibacterial,anticancer,anti-inflammatory,antioxidative,anthelmintic,and anti-mood disorder properties,and discuss their potential applications in the food,medicinal,and agricultural fields.This review highlights the need for future studies to focus on regulating the biosynthesis of VOCs,unraveling their bioactivity,and developing efficient synthetic and extraction methods to enable sustainable advancements in related fields. 展开更多
关键词 Volatile organic compound Biosynthetic pathway Regulation Bioactivity Application Prospect
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Dual regulation of antiviral IFN response by Scutellariae Radix:Therapeutic implications for influenza 认领 引用
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作者 Li Li Manjing Jiang +9 位作者 Hong Wei Linpan Liang Yunlong Song Dongni Xia Qiang Luo Huimin Huang Xu Li Haisheng Yang Lijun Ning Ying Wu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期756-774,共19页
Scutellariae Radix(SR)is widely used in Chinese medicine for influenza treatment;however,the mechanisms underlying its effect remain unknown.Here,we report,for the first time,that the therapeutic effects of SR on infl... Scutellariae Radix(SR)is widely used in Chinese medicine for influenza treatment;however,the mechanisms underlying its effect remain unknown.Here,we report,for the first time,that the therapeutic effects of SR on influenza involve regulation of antiviral interferons(IFNs),typeⅠand typeⅢIFNs(IFN-Is and IFN-Ⅲs,respectively),particularly through the modulation of IFN-I production and its downstream effects in a cell type-specific manner.SR treatment resulted in symptomatic improvement in A/Puerto Rico/8/34(H1N1)virus(PR8)-infected mice.It exhibited direct antiviral activity in the early stages of virus infection in A/WSN/33(H1N1)(WSN)-infected Madin-Darby canine kidney(MDCK)cells.Next,we investigated the effects of SR on the upstream antiviral IFN pathways and downstream effects in human lung adenocarcinoma(A549)cells,human monocytic leukemia(THP-1)cells,and neutrophils(Neu).SR exhibited dual regulatory roles,enhancing the production and activity of antiviral IFNs via the nuclear factor-kappaB(NF-κB)/IFN regulatory factor 3(IRF3)and Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathways.It also reduced IFN-I-induced neutrophil inflammation by inhibiting reactive oxygen species(ROS)and neutrophil extracellular trap(NET)production,and alleviated inflammation in A549 and THP-1 cells via NF-κB/cFOS or mitogen-activated protein kinase(MAPK)/c-Jun signaling.Subsequently,the importance of IFN-Ⅰ/IFN-Ⅲwas verified using IFN alpha receptor 1(Ifnar1)-/-and IFN lambda receptor 1(Ifnlr1)-/-mice.The absence of IFNAR or IFNLR significantly diminished the therapeutic effect of SR against influenza,highlighting its dependence on the IFN-Ⅰ/IFN-Ⅲsystems.Finally,a delayed drug administration experiment in PR8-infected mice revealed that the therapeutic effect of SR heavily relies on early induction of IFN.Overall,our findings offer valuable insights for the clinical utilization of SR,as well as for further exploration of antiviral treatments. 展开更多
关键词 Scutellariae Radix Dual regulation TypeⅠinterferon TypeⅢinterferon Influenza
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Enhancement of cycling and environmental stability of O3-NaNi0.5Mn0.5O2 cathode materials by surface structure regulation 认领 引用
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作者 Zhen-fei CAI Meng-qin TAO +8 位作者 Shuai WANG Cheng LIU Shi-miao CHEN Jun-zhe LI Bo DING Yang-zhou MA Guang-sheng SONG Dong-ming LIU Cui-e WEN 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第5期1672-1684,共13页
O3-type NaNi0.5Mn0.5O2 cathode material was modified with NH4VO3 solution through a one-step liquid-phase method.The effects of NH4VO3 solution treatment on the phase structure and electrochemical... O3-type NaNi0.5Mn0.5O2 cathode material was modified with NH4VO3 solution through a one-step liquid-phase method.The effects of NH4VO3 solution treatment on the phase structure and electrochemical performance of NaNi0.5Mn0.5O2 were investigated.X-ray diffraction reveals that the use of auxiliary solvent and secondary heat treatment induces the formation of a V2O3/P2/O3 multiphase structure.The electrochemical results indicate that the multi-level structure can alleviate Jahn-Teller distortion and suppress irreversible phase transitions.Besides,the in-situ reconstruction layer can hinder the formation of hydrated phases,further enhancing the environmental stability of NaNi0.5Mn0.5O2.Consequently,the modified NaNi0.5Mn0.5O2 cathode material achieves an excellent capacity retention of 74.9%after 1000 cycles at 5C(1C=150 mA/g),whereas the original sample only retains 42.6% of its capacity.These results indicate that NH4VO3 surface treatment is an effective strategy for improving the stability of NaNi0.5Mn0.5O2. 展开更多
关键词 sodium-ion batteries layered oxide cathode surface structure regulation cycling stability
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Phase content regulation of P2/O3-type biphasic layered oxides for stable sodium ion storage 认领 引用
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作者 Liang Gao Xue-Yan Wu +7 位作者 Xuheng Jiang Jing-Zhe Wan Jia-Ning Yang Shang-Qi Li Qinfeng Zheng Yixiao Zhang Jie-Sheng Chen Kai-Xue Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第4期317-325,I0008,共9页
P2/O3 composite layered transition metal oxides(LTMOs),constructed by elemental doping,markedly improve sodium storage performance.However,the influence of the doped elements,which usually contribute to electrochemica... P2/O3 composite layered transition metal oxides(LTMOs),constructed by elemental doping,markedly improve sodium storage performance.However,the influence of the doped elements,which usually contribute to electrochemical activity,on the electrochemical performance of the resulting biphasic materials could hardly be ruled out.Herein,three compositionally identical P2/O3-Na0.67Fe0.42Li0.08Mn0.45Sn0.05O2materials are synthesized by calcination at 900℃ for 14,12,and 10 h,yielding P2/O3 ratios of approximately 6:1,3:1,and 2:3,respectively.The resulting materials are designated as PO61,PO31,and PO23,respectively.Cycled at 1 C within the voltage range of 2.0-4.5 V,an initial discharge capacity of 118.3 mAh g-1is delivered by PO31,with a retention rate of 81.1%after 100 cycles,significantly outperforming those of PO61(106.8 mAh g-1,65.0%)and PO23(83.9 mAh g-1,61.5%).Systematic investigation of the charge/discharge behaviour reveals that the mitigated phase transition and enhanced cycling performance in these P2/O3 biphasic materials originate from the formation of shorter Fe-O bonds,which promote structural stabilization.This work provides fundamental insights into phase content regulation and advances the development of LTMOs. 展开更多
关键词 Sodium-ion batteries Biphasic materials Layered oxides Phase content regulation Phase transition
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H∞Optimal Output Regulation of Unknown Linear Systems via an Adaptive Dynamic Programming and Internal Model 认领 引用
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作者 Yong-Sheng Ma Jian Sun Yong Xu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第6期1314-1324,共11页
This paper delves into the H∞optimal output regulation problem for continuous-time linear systems with an unknown system model.By integrating the internal model principle with optimal control,we derive an optimal con... This paper delves into the H∞optimal output regulation problem for continuous-time linear systems with an unknown system model.By integrating the internal model principle with optimal control,we derive an optimal control policy and a worst-case disturbance policy through the formulation and solution of a zero-sum game problem.Subsequently,leveraging adaptive dynamic programming,we propose a policy iteration learning algorithm capable of learning both the optimal control policy and the worst-case disturbance policy directly from system data.The existing algorithms necessitate an initial stabilizing policy,a full-rank condition,and the storage of historical data to guarantee algorithm convergence.In contrast,we design a dual policy iteration algorithm equipped with an online learning mechanism,thereby eliminating these additional prerequisites.Simulation results with an antonomous ground vehicle underscore the effectiveness of our proposed algorithm,and its superiority is further demonstrated through comparisons with existing methodologies. 展开更多
关键词 Adaptive dynamic programming internal model principle optimal control output regulation
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