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A Network Partition Algorithm for Mining Gene Functional Modules of Colon Cancer from DNA Microarray Data 认领 引用
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作者 Xiao-Gang Ruan Jin-Lian Wang Jian-Geng Li 《Genomics, Proteomics & Bioinformatics》 CAS 2006年第4期245-252,共8页
Computational analysis is essential for transforming the masses of microarray datainto a mechanistic understanding of cancer. Here we present a method for findinggene functional modules of cancer from microarray data ... Computational analysis is essential for transforming the masses of microarray datainto a mechanistic understanding of cancer. Here we present a method for findinggene functional modules of cancer from microarray data and have applied it tocolon cancer. First, a colon cancer gene network and a normal colon tissue genenetwork were constructed using correlations between the genes. Then the modulesthat tended to have a homogeneous functional composition were identified by split-ting up the network. Analysis of both networks revealed that they are scale-free.Comparison of the gene functional modules for colon cancer and normal tissuesshowed that the modules’ functions changed with their structures. 展开更多
关键词 DNA microarray data colon cancer gene functional module GN algorithm
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