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Determinations of the Configuration of C-20 in Derivatives of Adynerin Using DFT/HF Methods 认领 引用 被引量：3
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作者 HUA Yan REN Jie +1 位作者 CHEN Chang-xiang ZHU Hua-jie 《Chemical Research in Chinese Universities》 SCIE CAS 2007年第5期592-597,共6页
The configurations of C-20 in derivatives of novel 5α-adynerin type,co-existing glycoside in pair,were identified with the calculated chemical shifts of carbon at the B3LYP/6-311＋G（2d,p）level.These glycosides are ... The configurations of C-20 in derivatives of novel 5α-adynerin type,co-existing glycoside in pair,were identified with the calculated chemical shifts of carbon at the B3LYP/6-311＋G（2d,p）level.These glycosides are unusual cardic aglycones without the common olefin bond in ring E. 展开更多
关键词 Configuration determination Adynerin derivative B3LYP GIAO NMR computation
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The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells 认领 引用
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作者 Jianghong Xiang Yihan Lai Zuping He 《Research》 SCIE EI CSCD 2026年第2期847-862,共16页
Stem cells have important applications in both regenerative and reproductive medicine.The cohesin complex comprises 4 core subunits,namely,SMC1,SMC3,RAD21,and STAG,and notably,it plays pivotal roles in controlling the... Stem cells have important applications in both regenerative and reproductive medicine.The cohesin complex comprises 4 core subunits,namely,SMC1,SMC3,RAD21,and STAG,and notably,it plays pivotal roles in controlling the fate determinations of stem cells by facilitating the dynamic regulation of the 3-dimensional genome architecture.We have recently reported that RAD21 forms a complex with YAP1 and NEDD4 to promote the self-renewal of human spermatogonial stem cells and inhibit their apoptosis.In this review,we address the molecular properties of the cohesin complex and its multiple regulatory mechanisms in mediating the fate decisions of various kinds of stem cells,including hematopoietic stem cells,embryonic stem cells,spermatogonial stem cells,neural stem cells,and other types of stem cells.By maintaining the chromatin loop structure,the cohesin complex is involved in DNA repair and gene transcription,which in turn controls the pluripotency,self-renewal,and differentiation of stem cells.In addition,the cohesin complex ensures faithful DNA replication and sister chromatid cohesion,which indirectly supports genetic and epigenetic programs.Variants in the subunit components of the cohesin complex and proteins'modifications further confer functional plasticity,and its mutations can lead to abnormal stem cell functions and are correlated with diseases including cancers.Future studies need to integrate multidisciplinary approaches including single-cell multi-omics and cryo-electronic microscopy to resolve the dynamic regulatory networks of the cohesin complex in stem cell fate regulation and further explore its potential applications in regenerative and reproductive medicine. 展开更多
关键词 stem cells spermatogonial stem cells neural stem cells controlling fate determinations stem cell fate determination embryonic stem cells cohesin complex hematopoietic stem cells
Essential Regulation of YAP1 in Fate Determinations of Spermatogonial Stem Cells and Male Fertility by Interacting with RAD21 and Targeting NEDD4 in Humans and Mice 认领 引用 被引量：2
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作者 Chunyun Li Wei Chen +4 位作者 Yinghong Cui Dong Zhang Qingqing Yuan Xing Yu Zuping He 《Research》 SCIE EI CSCD 2025年第3期556-573,共18页
Spermatogenesis is a sophisticated biological process by which spermatogonial stem cells(SSCs)undergo self-renewal and differentiation into spermatozoa.Molecular mechanisms underlying fate determinations of human SSCs... Spermatogenesis is a sophisticated biological process by which spermatogonial stem cells(SSCs)undergo self-renewal and differentiation into spermatozoa.Molecular mechanisms underlying fate determinations of human SSCs by key genes and signaling pathways remain elusive.Here,we report for the first time that Yes1-associated transcriptional regulator(YAP1)is required for fate determinations of SSCs and male fertility by interacting with RAD21 and targeting NEDD4 in humans and mice.YAP1 was mainly located at cell nuclei of human SSCs.YAP1 silencing resulted in the decreases in proliferation and DNA synthesis as well as an enhancement in apoptosis of human SSCs both in vivo and in vitro.RNA sequencing and real-time polymerase chain reaction assays identified NEDD4 as a target of YAP1,and NEDD4 knockdown inhibited the proliferation of human SSCs and increased their apoptosis.Furthermore,YAP1 interacted with RAD21 to regulate NEDD4 transcription in human SSCs.Importantly,YAP1 abnormalities were found to be associated with non-obstructive azoospermia(NOA)as manifested as lower expression level of YAP1 in testicular tissues of NOA patients and YAP1 single-nucleotide variants(SNVs)in 777 NOA patients.Finally,Yap1 germline conditional knockout(cKO)mice assumed mitotic arrest,low sperm count,and motility.Collectively,these results highlight a critical role of YAP1 in determining the fate determinations of human SSCs and male infertility through the YAP1/RAD21/NEDD4 pathway.This study provides new insights into the genetic regulatory mechanisms underlying human spermatogenesis and the pathogenesis of NOA,and it offers new targets for gene therapy of male infertility. 展开更多
关键词 fate determinations YAP signaling pathways spermatogonial stem cells sscs undergo Spermatogonial Stem Cells Male Fertility targeting nedd RAD
Research on the visualization method of lithology intelligent recognition based on deep learning using mine tunnel images 认领 引用 被引量：2
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作者 Aiai Wang Shuai Cao +1 位作者 Erol Yilmaz Hui Cao 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第1期141-152,共12页
An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction... An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects. 展开更多
关键词 rock picture recognition convolutional neural network intelligent support for roadways deep learning lithology determination
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Breaking the boundaries of affinity selection-mass spectrometry:From ligand screening to target-ligand interaction insights 认领 引用 被引量：1
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作者 Pamella Christina Ortega de Oliveira Bruno Sergio do Amaral +2 位作者 Carmen Lucia Cardoso Quezia Bezerra Cass Marcela Cristina De Moraes 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期347-358,共12页
Affinity selection mass spectrometry(AS-MS)has emerged as a powerful label-free technique for identifying and characterizing ligand-target interactions.This review explores the diverse applications of AS-MS in drug di... Affinity selection mass spectrometry(AS-MS)has emerged as a powerful label-free technique for identifying and characterizing ligand-target interactions.This review explores the diverse applications of AS-MS in drug discovery,including its role in selective screening,binding site characterization,and quantitative affinity determination.We discuss the use of AS-MS for determining equilibrium dissociation constants(KD)and competitive binding parameters(affinity competition experiment 50%(ACE50)),highlighting its ability to rank ligand affinities efficiently.The review also examines AS-MS applications in fragment-based drug discovery(FBDD),screening for molecular glues,and investigating interactions with membrane proteins.Moreover,we address key technical challenges,including competitive binding effects,protein stability,and ligand dissociation kinetics,along with recent advancements in automation and artificial intelligence(AI)integration.Rather than providing a comprehensive literature review,this work aims to broaden the applicability of AS-MS assays and encourage researchers to explore its use in underutilized contexts.By providing rapid and high-sensitivity affinity measurements,AS-MS continues to expand its role in drug discovery and structural biology,complementing conventional biophysical techniques. 展开更多
关键词 Affinity selection mass spectrometry Competition assays Drug discovery Fragment screening KD determination Ligand-target interactions Molecular glues
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Understanding the urban–rural divide in elderly poverty in China 认领 引用
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作者 WANG Xia JIANG Yuxuan +4 位作者 ADILI Meilikezhati GAN Yuqing JIANG Songnian WU Lijun HE Yihao 《Journal of Geographical Sciences》 SCIE CSCD 2026年第4期987-1016,共30页
Addressing poverty among the elderly is essential for achieving sustainable development objectives.Despite considerable research progress on elderly poverty,studies that explore this topic from the perspective of spat... Addressing poverty among the elderly is essential for achieving sustainable development objectives.Despite considerable research progress on elderly poverty,studies that explore this topic from the perspective of spatial changes in urban-rural differences are scarce.This study aims to fill this gap by utilising data from the Chinese Longitudinal Healthy Longevity Survey covering the years 2011,2014 and 2018.This research applies the Alkire-Foster and Geodetector methods and investigates the spatial variations and determinants of urban-rural differences in elderly poverty(URDEP).Results reveal that rural elderly individuals experience higher poverty levels than their urban counterparts.In addition,URDEP is lower in developed areas and more pronounced in less-developed regions.This study identifies several factors that influence spatial changes in URDEP,including urban-rural income gap,economic level and quality of community elderly care services.These findings offer valuable insights into reducing elderly poverty and enriching the understanding of mechanisms driving spatial changes in URDEP from a geographical perspective. 展开更多
关键词 elderly poverty urban-rural differences spatial variations determinants Geodetector
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FPS_P/N:A two-dimensional mass spectrometry utilization program with precursor ion determination for accurately distinguishing anthocyanin from other flavonoids 认领 引用
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作者 Ya-Hui Ge Lili Zhang +5 位作者 Shilin Gong Wen Miao Li Zhang Weibin Bai Jian-Lin Wu Na Li 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期232-241,共10页
Anthocyanins,a unique class of flavonoids with flavylium skeletons,are valued for antioxidant properties.However,distinguishing anthocyanins from co-existing flavonoids using conventional automated tandem mass spectro... Anthocyanins,a unique class of flavonoids with flavylium skeletons,are valued for antioxidant properties.However,distinguishing anthocyanins from co-existing flavonoids using conventional automated tandem mass spectrometry(MS)analysis methods remains challenging.This difficulty arises from low specificity of MS features and confusion of precursor ions,leading to substantial false confidence annotations.To address it,we have developed the strategy of positive(POS)-to-negative(NEG)primary MS(MS1)intensity ratios detecting with fast polarity switching(FPS),termed FPS-POS/NEG,to determine their specific precursor ions.Moreover,we developed an automated program leveraging FPS-POS/NEG strategy(FPS_P/N)streamlining screening candidate pool with molecular networking analysis from MS1 and secondary MS(MS2),determining precursor ions with FPS-POS/NEG,and annotation with MS2.This program enables simultaneous capture of positive and negative signals in a single run and accurate determination of precursor ions for anthocyanins(5.98–9.28)and other flavonoids(−2.52 to 2.08).The underlying mechanisms were elucidated by difference in protonated and deprotonated Gibbs free energy(ΔG)and in-source fragmentation(ISF).FPS-POS/NEG strategy was validated across a broad pH range(0.1%–2%formic acid(FA))and demonstrated high alignment accuracy(retention time difference,0.011 min)and consistency(relative standard deviation(RSD),0.38%–4.62%).Using blueberry,20 anthocyanins(nonacylated and acylated)and 14 additional flavonoids were annotated.With two-dimensional integration of positive and negative MS1intensities with intensity ratios,FPS_P/N program provides a novel way to identify anthocyanins from other flavonoids.We anticipate this innovative method will enhance the high-throughput qualification of anthocyanins and other flavonoids in complex samples. 展开更多
关键词 Anthocyanins Flavonoids Precursor ion determination High-throughput metabolomics analysis Fast polarity switching
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Ratiometric fluorescent probes based on nitrogen-doped carbon dots for the fluorescence detection of sulfide ions 认领 引用
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作者 CAI Zhifeng ZHANG Yiran +3 位作者 CAI Qun JIA Miao FENG Yaxuan ZHANG Yuqi 《无机化学学报》 SCIE CAS CSCD 北大核心 2026年第5期1015-1025,共11页
Herein,ratiometric fluorescence-based carbon dots(N-CDs)with blue emission were prepared by using simple one-step hydrothermal methods from benzimidazole and L-tryptophan as precursors.Dual emission peaks were observe... Herein,ratiometric fluorescence-based carbon dots(N-CDs)with blue emission were prepared by using simple one-step hydrothermal methods from benzimidazole and L-tryptophan as precursors.Dual emission peaks were observed at 356 and 442 nm under the excitation wavelength of 303 nm.Upon addition of sulfide ions(S2-),the fluorescence intensity at 442 nm decreased significantly,while that at 356 nm increased.The F442/F356 intensity ratio(where F356 and F442 refer to the fluorescence intensity at 356 and 442 nm,respectively)exhibited a linear relationship with the concentration of S2-(0-60.0μmol·L-1),and the detection limit was determined to be 0.076μmol·L-1.The fluorescence detection mechanism was ascribed to the static quenching effect.Furthermore,this fluorescence probe was successfully used for the determination of S2-in real samples with satisfactory recoveries.Finally,the analytical greenness metric for sample preparation(AGREEprep)and blue applicability grade index(BAGI)tools indicated the high sustainability of this platform. 展开更多
关键词 amino acid-based carbon dots ratiometric determination sulfide ions real samples
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Direct position determination based on rotating single-baseline interferometer for multiple time-frequency aliased sources 认领 引用
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作者 Yuan ZHANG Guizhou WU +2 位作者 Fucheng GUO Zihan YAO Min ZHANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第2期389-401,共13页
Rotating Single-Baseline Interferometer(RSBI)systems have attracted considerable attention for Direct Position Determination(DPD)due to their simplicity and high localization accuracy.Nevertheless,the growing complexi... Rotating Single-Baseline Interferometer(RSBI)systems have attracted considerable attention for Direct Position Determination(DPD)due to their simplicity and high localization accuracy.Nevertheless,the growing complexity of electromagnetic environments has led to scenarios with multiple time-frequency aliased sources,rendering conventional DPD methods for RSBI systems ineffective.Previous studies have predominantly concentrated on deploying antenna arrays and applying related signal-processing techniques for localization.Typically,these approaches necessitate that the number of physical antennas exceeds the number of sources.For RSBI systems already in practical operation,this would entail the installation of additional physical antennas,which implies equipment recycling and hardware upgrades.In numerous cases,such modifications are unfeasible.This paper proposes a novel Relative Offset-based Direct Position Determination(RO-DPD)method for RSBI systems that can handle multiple time-frequency aliased sources.The proposed method overcomes the challenge of simultaneous positioning without requiring hardware modifications by leveraging time accumulation and algorithmic enhancements.The implementation of the method involves three key steps.Firstly,the rotation of the interferometer is synthesized into a virtual Uniform Circular Array(UCA).Secondly,a novel estimation variable,termed relative offset,is introduced.The variable serves as an intermediate parameter to establish correlation equations between the positions of multiple time-frequency aliased sources and the intercepted signals.Thirdly,the relative offset model in the UCA is transformed into a virtual Uniform Linear Array(ULA)model,from which the cost function can be derived via the Spatial Smoothing(SS)MUSIC algorithm.Theoretical analysis and simulation results verify the effectiveness of the proposed method.Compared with traditional approaches,the RO-DPD method maintains the low complexity of RSBI systems while demonstrating robust performance in complex electromagnetic environments. 展开更多
关键词 Rotating single-baseline interferometer Direct position determination Uniform circular array Array processing
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A Nationwide Analysis of Key Environmental Determinants Shaping the Spatial Distribution of Kashin-Beck Disease in China 认领 引用
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作者 Fang Qi Ying Liu +9 位作者 Bing Zhang Qian Yu Songyao Zhang Haoyu Du Jiaxin Li Yue Zhao Chenxi Wang Jiayuan Li Silu Cui Jun Yu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第5期609-615,共7页
Kashin-Beck disease(KBD)is an endemic,deformative osteoarthropathy characterized by distinct geographic clusters[1].Historically,13 provinces and autonomous regions in China have been designated as KBD-affected areas.... Kashin-Beck disease(KBD)is an endemic,deformative osteoarthropathy characterized by distinct geographic clusters[1].Historically,13 provinces and autonomous regions in China have been designated as KBD-affected areas.In severely endemic areas,the radiographic detection rate had reached up to 80%[1].Although comprehensive prevention and control measures,including dietary restructuring,grain substitution,and relocation of educational facilities,have successfully halted new pediatric cases,the persistent threat posed by environmental risk factors suggests that the relaxation of these measures could lead to the resurgence of KBD. 展开更多
关键词 relocation educational facilitieshave radiographic detection dietary restructuringgrain Kashin Beck disease prevention control measuresincluding environmental determinants China spatial distribution
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Particle-size distribution and respiratory deposition of airborne pathogens and antimicrobial resistance risk determinants in wastewater treatment plants 认领 引用
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作者 Shanshan Gao Shaobin Li +4 位作者 Yajie Guo Qiaolin Xu Mo Chen Min Gao Xuming Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期752-762,共11页
Air in wastewater treatment plants(WWTPs)contains high concentrations of pathogens and antimicrobial resistance determinants(ARDs).However,limited information on their particle-size distribution hinders assessment of ... Air in wastewater treatment plants(WWTPs)contains high concentrations of pathogens and antimicrobial resistance determinants(ARDs).However,limited information on their particle-size distribution hinders assessment of occupational inhalation exposure risks in WWTPs.In this study,air samples above the aeration tanks and the secondary sedimentation tanks of WWTPs were collected using Anderson eight-stage air samplers,and the size-resolved bacterial community was characterized by 16S rRNA gene sequencing.The inhalation deposition of ARDs and pathogens in the human respiratory tract was quantitatively evaluated by droplet digital PCR.Results showed that airborne bacterial concentrations above the aeration tank increased with particle size,ranging from 2914 to 5645 copies/m3.By contrast,concentrations above the secondary sedimentation tank exhibited a bimodal distribution,with peaks at 5.8-9.0μm(5592 copies/m3)and 0.65-1.1μum(5302 copies/m3).The most prevalent airborne antibiotic resistance genes were tetW and floR,associated with aerodynamic diameters of 2.64μm and 3.43μm,respectively.The International Commission on Radiological Protection deposition model indicated that airborne pathogens and ARDs were primarily deposited in the upper respiratory tract(17.73-165.63 copies/h)and alveoli(1.84-14.63 copies/h).Notably,deposition densities of Escherichia coli and Enterococcus faecium reached 2.26-36.20 copies/hand 1.62-31.31 copies/h,respectively.Co-occurrence of these pathogens with floR and sulⅡin fine particulate matter may pose significant health risks.This study elucidates the size distribution and respiratory deposition behavior of ARDs and pathogens in WWTP air,addressing critical knowledge gaps for comprehensive assessment of airborne antimicrobial resistance and associated occupational health risks. 展开更多
关键词 Particle size distribution Respiratory deposition Antimicrobial resistance risk determinants(ARDs) Pathogen Wastewater treatment plants(WWTPs)
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IMPROVEMENT ON HANKEL DETERMINANT BOUNDS FOR SPECIFIC HOLOMORPHIC FUNCTIONS 认领 引用
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作者 Huo TANG Muhammad ABBAS +1 位作者 Reem K.ALHEFTHI Muhammad ARIF 《Acta Mathematica Scientia》 SCIE CSCD 2026年第1期39-61,共23页
In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov ... In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions. 展开更多
关键词 holomorphic function Carathéodory function Hankel determinant Zalcman inequality
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Pressure calibrations of high-pressure large-volume presses at HPSTAR 认领 引用
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作者 Yongjiang Xu Peiyan Wu +17 位作者 Sheng Shang Xue Wang Taihang Li Shuchang Gao Shijie Lv Hang Cheng Qianzhi Xu Shang Lei Jiajia Feng Lei Zhao Wim van Westrenen Takayuki Ishii Bin Chen Lei Su Yang Ding Wenge Yang Ho-Kwang Mao Yanhao Lin 《Matter and Radiation at Extremes》 SCIE EI CAS CSCD 2026年第1期111-130,共20页
Large-volume presses(LVPs)are widely utilized in diverse research fields—including high-pressure physics,chemistry,materials science,and Earth and planetary sciences—to investigate the physical and chemical properti... Large-volume presses(LVPs)are widely utilized in diverse research fields—including high-pressure physics,chemistry,materials science,and Earth and planetary sciences—to investigate the physical and chemical properties of materials under extreme high-pressure and hightemperature conditions.A prerequisite for achieving reproducible property measurements is the determination and control of pressure within experimental setups.However,the lack of precise pressure calibration in LVPs hinders the broader application of such devices in ultrahigh-pressure studies.This study employs a suite of standard phase transition-based pressure markers—comprising metallic conductors,semiconductors,and minerals—through both in situ and ex situ identification approaches,to establish pressure calibration curves ranging from 0.4 to>30 GPa for various types of LVP installed at the Center for High Pressure Science and Technology Advanced Research(HPSTAR),Beijing,including piston–cylinder,cubic,and multi-anvil presses.The results provide a unified and traceable pressure reference for highpressure experiments conducted at HPSTAR,while also offering technical guidance and calibration standards for other researchers utilizing similar LVP systems,thereby enabling more consistent comparison between different laboratories.This work facilitates the advancement of LVP research toward broader applications in higher-pressure regimes. 展开更多
关键词 chemistry earth planetary sciences pressure calibration high pressure physics materials science investigate physical chemical properties materials determination control pressure
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Spatiotemporal Variability of Influencing Factors on Tuberculosis Incidence in Jiangsu Province,China during 2011−2021 认领 引用
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作者 Yifan Tang Tenglong Li +7 位作者 Cheng Chen Kai Wang Mingming Chen Junhui Lin Sifan Wang Limei Zhu Chengxiu Ling Qiao Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期234-238,共5页
Tuberculosis(TB),one of the oldest infectious diseases caused by Mycobacterium tuberculosis,poses a considerable challenge to global public health.There are approximately 10 million new TB cases worldwide annually,and... Tuberculosis(TB),one of the oldest infectious diseases caused by Mycobacterium tuberculosis,poses a considerable challenge to global public health.There are approximately 10 million new TB cases worldwide annually,and TB claims the lives of nearly 3 million people each year,making it one of the leading causes of death from a single infectious disease[1].China ranks third globally in terms of TB burden,with approximately 733,000 TB cases reported in 2023[2].Based on the ecological model of health determinants developed by Whitehead and Dahlgren,health determinants can be classified into direct causes. 展开更多
关键词 tuberculosis incidence infectious diseases influencing factors mycobacterium tuberculosisposes spatiotemporal variability China ecological model health determinants jiangsu province
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Psychological state and body image disturbance in head and neck cancer patients:Prevalence and determinants 认领 引用
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作者 Xu-Dong Gao Yu Ding +2 位作者 An Li Xin Chen Yu-Juan Wang 《World Journal of Psychiatry》 SCIE 2026年第6期318-325,共8页
BACKGROUND Head and neck cancer(HNC)usually imposes a psychological burden on patients.In particular,treatment-related facial changes often predispose them to body image disturbance(BID),thereby exacerbating psycholog... BACKGROUND Head and neck cancer(HNC)usually imposes a psychological burden on patients.In particular,treatment-related facial changes often predispose them to body image disturbance(BID),thereby exacerbating psychological stress.AIM To characterize the psychological state(anxiety,depression)and BID status in patients with HNC and to identify determinants associated with BID.METHODS A total of 100 patients with HNC treated between January 2020 and January 2025 were analyzed.The psychological state was assessed using the Hospital Anxiety and Depression Scale-Anxiety(HADS-A)and Hospital Anxiety and Depression Scale-Depression(HADS-D)subscales,while body image-related distress was evaluated using the Body Image Scale(BIS).Linear associations among scales were examined using Pearson’s or Spearman’s correlation coefficients.Potential predictors of BID were evaluated using univariate and multivariable regression models.RESULTS Anxiety and depressive symptoms were identified in 25%and 30%of patients,respectively.Mean HADS-A and HADS-D scores were(5.62±2.89)and 5.00(3.00,8.00),respectively,while the BIS total score was 16.00(14.00,18.00).Global BIS scores and all BIS domains(affective,cognitive,and behavioral)correlated positively with both HADS-A and HADS-D scores.Regression analyses identified multimodal treatment[odds ratio(OR)=6.730,P=0.011],female sex(OR=5.206,P=0.003),disease progression(OR=4.316,P=0.012),unemployment(OR=3.461,P=0.042),anxiety(HADS-A;OR=4.031,P=0.036),and depression(HADS-D;OR=3.690,P=0.039).CONCLUSION Patients with HNC commonly present with mild psychological issues accompanied by moderate BID.Female patients,those with late-stage cancer(III-IV),recipients of multimodal therapy,unemployed individuals,and patients with anxiety or depressive symptoms are at greater risk of BID. 展开更多
关键词 Head and neck cancer Psychological state Body image disturbance Determinants Hospital Anxiety and Depression Scale
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Searches for New Physics Beyond the Standard Model in Hyperon Sector 认领 引用
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作者 Jianyu Zhang Jinlin Fu Hai-Bo Li 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第6期15-21,共7页
Hyperon physics offers a distinctive laboratory for probing the intensity frontier and searching for physics beyond the Standard Model.This review summarizes recent results from the BESIII experiment,including pioneer... Hyperon physics offers a distinctive laboratory for probing the intensity frontier and searching for physics beyond the Standard Model.This review summarizes recent results from the BESIII experiment,including pioneering studies of dark baryons,massless BSM particles,and invisible decay modes,together with investigations of baryon-and lepton-number violation.A central highlight is the determination of theΛelectric dipole moment using quantum-entangled hyperon-antihyperon pairs,achieving a sensitivity three orders of magnitude beyond previous limits.These measurements provide world-leading constraints on new physics scenarios and establish a robust foundation for next-generation precision studies.By integrating experimental progress with theoretical developments and future facility prospects,this review emphasizes the critical role of hyperon probes in testing the fundamental laws of nature. 展开更多
关键词 besiii experimentincluding standard modelthis dark baryonsmassless determination electric dipole moment invisible decay modestogether probing intensity frontier hyperon physics dark baryons
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Modernization of traditional Chinese medicine in cancer therapy:“3 D”innovative Chinese medicine 认领 引用
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作者 Hui Liu Yunxiao Ge Zigang Dong 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第2期189-202,共14页
Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for... Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide. 展开更多
关键词 Traditional Chinese medicine Innovative Chinese medicine Definite active ingredient composition and content Determined functional mechanism Detection through evidence-based medicine Cancer therapy Drug discovery
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Anxiety and depression in relation to resilience and quality of life in patients with kidney calculi 认领 引用
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作者 Da-Wei Luo Hai-Liang Du 《World Journal of Psychiatry》 SCIE 2026年第3期220-228,共9页
BACKGROUND Anxiety and depression are understudied in kidney calculi despite their inverse cor-relation with clinical outcomes.AIM To investigate the correlation of anxiety and depression with resilience and quality o... BACKGROUND Anxiety and depression are understudied in kidney calculi despite their inverse cor-relation with clinical outcomes.AIM To investigate the correlation of anxiety and depression with resilience and quality of life(QoL)in patients with kidney calculi,and to identify contributors to these emotional disorders in such patients.METHODS This study included 119 patients with kidney calculi who visited the First Affiliated Hospital of Xi’an Jiaotong University from May 2022 to March 2025.Patients’anxiety[Hamilton Self-Rating Anxiety Scale(HAMA)],depression[Hamilton Self-Rating Depression Scale(HAMD)],resilience[Connor-Davidson Resilience Scale(CD-RISC)],and QoL[General QoL Inventory-74(GQOLI-74)]were assessed.Spearman correlation coefficients were calculated to analyze the correlations of anxiety and depression with resilience and QoL.Multivariate modeling identified anxiety and depression contributors in patients with kidney calculi.RESULTS Anxiety and depressive symptoms affected 49.58%and 64.71%of participants,respectively.Notably lower CD-RISC scores(across tenacity,strength,and optimism dimensions and the global scale)were observed in the anxiety/depression groups vs their corresponding non-anxietyon-depression groups.The same pattern was observed in GQOLI-74 global and subscale scores.Both HAMA and HAMD correlated inversely with CD-RISC(HAMA:r=-0.194,P=0.034;HAMD:r=-0.413,P<0.001)and GQOLI-74(HAMA:r=-0.394,P<0.001;HAMD:r=-0.347,P<0.001).As confirmed by multivariate regression,per capita monthly income[odds ratio(OR)=0.158,P=0.002],complications(risk factor,OR=3.442,P=0.032),CD-RISC(OR=0.075,P<0.001),and GQOLI-74(OR=0.081,P<0.001)each independently affected anxiety risk.Depression-associated independent predictors included income(OR=0.090,P<0.001),social support(OR=0.136,P=0.003),CD-RISC(OR=0.060,P<0.001),and GQOLI-74(OR=0.198,P=0.023).CONCLUSION Anxiety and depression exhibited an intimate connection with resilience and QoL in patients with kidney calculi.High income,great resilience,and superior QoL are protective against psychological distress. 展开更多
关键词 Kidney calculi Anxiety Depression Resilience Quality of life Determinants
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Effect of confining pressures on the drilling parameters and specific energy:Insights into determining in situ stress using drilling monitoring techniques 认领 引用 被引量：1
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作者 Wendal Victor Yue Manchao He +3 位作者 Hehua Zhu Zhongwen Yue Sichen Long Mengjia Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第5期3471-3482,共12页
Current in-situ stress determination methods are typically conducted inside a drillhole after its creation.However,the drilling process itself is not utilized for measuring in-situ stress or rock strength,despite bein... Current in-situ stress determination methods are typically conducted inside a drillhole after its creation.However,the drilling process itself is not utilized for measuring in-situ stress or rock strength,despite being a form of direct mechanical testing on the rock mass.Crucially,drilling contains valuable information about in-situ stress and rock strength,as rocks under high compressive stresses exhibit greater strength.This paper presents a novel in-situ stress determination method,supported by the experimental result of rock drilling monitoring tests using a mine hydraulic-rotary drilling machine.Key drilling parameters—including thrust force,rotation speed,torque and drilling speed—are monitored in real time to determine the drilling specific energy per unit volume of rock.A concave-upward relationship between drilling specific energy and rotation speed is identified,which can characterize rock compressive strength and tensile strength with consistent regularity.Further drilling tests are conducted on the same rock samples under varying confining pressures.Results indicate that as confining pressure increases,the concave-upward curve of drilling specific energy shifts upward,reflecting enhanced rock strengths due to confinement.The paper outlines the complete methodology for in-situ stress determination using drilling monitoring techniques,bridging the research gaps among drilling monitoring,rock mechanics,and in-situ stress analysis. 展开更多
关键词 Drilling monitoring test Drilling specific energy In-situ stress determination Confining stresses
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AN INVESTIGATION OF PEDIGREES OF 110 PATIENTS WITH GRAVES' DISEASE AND THE CLINICAL SIGNIFICANCE OF DETERMINATIONS OF ANTITHYROID ANTIBODIES OF THEIR FIRST-DEGREE RELATIVES 认领 引用 被引量：1
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作者 王德全 王洁贞 +2 位作者 任建民 周显腾 彭万程 《Chinese Medical Journal》 SCIE CAS 1994年第11期19-23,共5页
Eight hundred and ten pedigree members of 110 patients with Graves' disease were studied. In 700 first-egree relatives, inquiry of medical history, physical examination (including eyes, thyroid, heart rate, etc), ... Eight hundred and ten pedigree members of 110 patients with Graves' disease were studied. In 700 first-egree relatives, inquiry of medical history, physical examination (including eyes, thyroid, heart rate, etc), thyroid function tests (serum T3, T4 and TSH levels), determinations of thyroglobulin antibodies (TgAb) and thyroid microsomal antibodies (TmAb) were performed. For male (female) probands, the incidence of Graves' disease in male (female) first-degree relatives were investigated and their serum TgAb and TmAb were analysed. The incidence of these two kinds of autoantibodies in the male (female) first-egree relatives of familial and nonfamilial Graves' disease were analysed. Eighteen persons with positive TgAb and TmAb from 5 pedigrees had been followed up one year after initial determinations. Our results suggest that the positive rates of TgAb and TmAb in the first-egree relatives of Graves' disease were coincident with the incidence of Graves' disease, and the positive results of TgAb and TmAb in the first-egree relatives of Graves' disease may be an indicator of pre-raves' disease or pre-utoimmune thyroid diseases. 展开更多
关键词 In AN INVESTIGATION OF PEDIGREES OF 110 PATIENTS WITH GRAVES DISEASE AND THE CLINICAL SIGNIFICANCE OF DETERMINATIONS OF ANTITHYROID ANTIBODIES OF THEIR FIRST-DEGREE RELATIVES 110 than
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