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Prevalence and clinical characteristics of diabetic retinopathy in patients newly diagnosed with ketosis-onset diabetes:A real-world study 认领 引用 被引量：1
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作者 Man-Rong Xu Meng-Han Li +4 位作者 Jun-Wei Wang Ya-Wen Zhang Jun-Xi Lu Jiang-Feng Ke Lian-Xi Li 《World Journal of Diabetes》 SCIE 2026年第3期127-138,共12页
BACKGROUND The classification of ketosis-onset diabetes is controversial,and the prevalence and clinical characteristics of diabetic retinopathy(DR)in ketosis-onset diabetes mellitus remain unclear.AIM To compare the ... BACKGROUND The classification of ketosis-onset diabetes is controversial,and the prevalence and clinical characteristics of diabetic retinopathy(DR)in ketosis-onset diabetes mellitus remain unclear.AIM To compare the prevalence and risk factors of DR among patients with type 1 diabetes mellitus(T1DM),ketosis-onset diabetes,and non-ketotic type 2 diabetes mellitus(T2DM).METHODS This real-world observational study enrolled 1777 patients with newly diagnosed diabetes between January 2003 and December 2012,including 211 with T1DM,673 with ketosis-onset diabetes,and 893 with non-ketotic T2DM.DR was assessed using digital nonmydriatic fundus photography,and its severity was graded based on the ETDRS classification.Clinical characteristics and risk factors of DR were compared across the three groups.RESULTS After controlling for age and sex,DR prevalence was significantly higher in ketosis-onset diabetes(9.5%)than in T1DM(5.7%,P=0.034),but not significantly different from non-ketotic T2DM(12.3%,P=0.105).Risk factors for DR in ketosis-onset diabetes and non-ketotic T2DM included increased estimated glomerular filtration rate(eGFR)and urinary albumin excretion.In contrast,elevated eGFR and 2-hour postprandial C-peptide were independent risk factors for DR in T1DM.The prevalence and risk factors for DR in ketosis-onset diabetes were similar to those in non-ketotic T2DM,but differed from T1DM.CONCLUSION These findings further support classifying ketosis-onset diabetes as a subtype of T2DM rather than idiopathic T1DM.However,the distinctive clinical features of ketosis-onset diabetes should not be ignored. 展开更多
关键词 Diabetic classification Ketosis-onset diabetes Diabetic retinopathy Type 1 diabetes Type 2 diabetes
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Prevalence of diabetic retinopathy across different diabetes phenotypes 认领 引用
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作者 Ashu Rastogi Anshu Khamesra 《World Journal of Diabetes》 SCIE 2026年第6期72-81,共10页
Diabetic retinopathy(DR)is a glucose-defining complication with varying prevalence reported depending upon the duration of diabetes,degree of glycemic control,and associated other microvascular complications,particula... Diabetic retinopathy(DR)is a glucose-defining complication with varying prevalence reported depending upon the duration of diabetes,degree of glycemic control,and associated other microvascular complications,particularly nephropathy,defined by albuminuria and reduced glomerular filtration rate.The prevalence of DR also varies with the diabetes phenotype,with ketosis-prone diabetes having DR as prevalent as type 2 diabetes,but less than type 1 diabetes,matched for age and gender.An increasing prevalence in ketosis-prone diabetes plausibly could be due to ketonemia increasing permeability of blood-retinal layer contributing to inflammation.The guidelines for initial screening and evaluation of DR suggest similar strategies across diabetes phenotypes.Recent advances in DR diagnosis with advanced imaging technologies with artificial intelligence shall enable earlier detection with improved accuracy across varied diabetes phenotypes to reduce preventable blindness due to DR. 展开更多
关键词 Diabetic retinopathy Ketosis prone diabetes Type 2 diabetes Type 1 diabetes Maturity-onset diabetes of the young Ketonemia Vascular permeability
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APOEε4 Allele Modifies the Association of Heavy Metals and their Mixture with Diabetes Mellitus among Chinese Community-Dwelling Older Adults 认领 引用
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作者 Lili Yao Ying Cao +10 位作者 Beibei Yin Qiang Liu Fusheng Lin Xuqiu Cheng Ziwei Tian Linsheng Yang Hongjuan Cao Liang Sun Fangbiao Tao Li Wang Guimei Chen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第1期123-128,共6页
In 2021,approximately 537 million people suffered from diabetes mellitus(DM)globally,and this figure will increase to approximately 783 million within the next quarter-century.The increasing burden of DM is a pressing... In 2021,approximately 537 million people suffered from diabetes mellitus(DM)globally,and this figure will increase to approximately 783 million within the next quarter-century.The increasing burden of DM is a pressing global public health issue.Therefore,the early identification of high-risk groups and implementation of effective intervention measures is imperative. 展开更多
关键词 effective intervention measures heavy metals Chinese community dwelling older adults global public health issue diabetes mellitus dm globallyand APOE allele diabetes mellitus early identification
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Association between self-compassion,meaning in life,resilience,health-related quality of life and diabetes self-management among people living with type 2 diabetes in Nigeria 认领 引用
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作者 Chinenye Joseph Aliche Erhabor Sunday Idemudia Ike E.Onyishi 《Journal of Psychology in Africa》 2026年第1期107-115,共9页
Self-compassion is an important psychological resource that improves health-related quality of life and diabetes self-management;however,the psychological processes underlying these associations remain unclear.This st... Self-compassion is an important psychological resource that improves health-related quality of life and diabetes self-management;however,the psychological processes underlying these associations remain unclear.This study examined the roles of meaning in life and resilience in the relationship between self-compassion and both health-related quality of life and diabetes self-management.Participants were 301 individuals living with type 2 diabetes(176(58.5%)females,M age=49.69,SD=12.36)conveniently selected from two tertiary healthcare institutions in Nigeria.They completed self-report measures of self-compassion,meaning in life,resilience,health-related quality of life and diabetes selfmanagement.Multiple regression analyses indicated that self-compassion positively predicted health-related quality of life and diabetes self-management.Meaning in life and resilience independently and positively predicted health-related quality of life and diabetes self-management.Mediation analysis showed that meaning in life mediated the association between self-compassion and health-related quality of life,as well as diabetes self-management.Likewise,resilience mediated the connection between self-compassion and health-related quality of life,and diabetes self-management behaviour.Intervention for diabetes self-management should focus on promoting self-compassion,meaning in life and resilience abilities of patients,as they can potentially improve health and self-care behaviours needed for recovery. 展开更多
关键词 Diabetes self-compassion resilience meaning in life health-related quality of life and diabetes selfmanagement
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New-onset diabetes mellitus after distal pancreatectomy:Incidence,predictors and clinical impact 认领 引用
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作者 Zoi Gkiafi Sofia Rozani 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第6期70-78,共9页
New-onset diabetes mellitus(NODM)represents a significant postoperative concern following distal pancreatectomy,arising from loss of functionalβ-cell mass and potential alterations in remnant pancreatic perfusion.Wit... New-onset diabetes mellitus(NODM)represents a significant postoperative concern following distal pancreatectomy,arising from loss of functionalβ-cell mass and potential alterations in remnant pancreatic perfusion.With increasing use of distal pancreatectomy for benign and malignant conditions,recognition of its metabolic consequences has become critical in long-term patient management.This review examines current evidence on the incidence,determinants,and clinical relevance of NODM after distal pancreatectomy.Published studies demonstrate a broad range of incidence rates,reflecting variability in surgical techniques,underlying disease processes,and diagnostic criteria for postoperative diabetes.Factors such as preoperative glucose intolerance,pancreatic steatosis,patient age,and the volume of preserved pancreatic tissue appear to play important roles in determining postoperative endocrine function.Additionally,technical considerations-including splenic preservation and maintenance of splenic vessel integrity,may influence the risk of NODM.Clinically,the development of NODM is associated with increased healthcare utilization,lifestyle adjustments,and potential long-term cardiovascular and metabolic complications.This review underscores the importance of early detection,risk stratification,and evidence-based followup strategies,while highlighting areas requiring further research to better understand and mitigate NODM after distal pancreatectomy. 展开更多
关键词 New-onset diabetes Distal pancreatectomy Pancreatectomy Type 3c diabetes Pancreatogenic diabetes
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Clinical guidelines on physical activity and exercise therapy for Chinese adults with type 2 diabetes:A clinical practice guideline from the Chinese Society of Endocrinology 认领 引用 被引量：1
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作者 Fang Zhang Jiajun Zhao +9 位作者 Yuwei Zhang Zhenjun Tian Jing Li Qingguo Lv Weiqing Wang Tianpei Hong Zhongyan Shan Li Yan Yongde Peng Nanwei Tong 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第5期44-76,共33页
Diabetes,a leading global chronic disease,poses a significant health threat,with physical inactivity being a major risk factor for its development and progression.This guideline,developed by the Chinese Society of End... Diabetes,a leading global chronic disease,poses a significant health threat,with physical inactivity being a major risk factor for its development and progression.This guideline,developed by the Chinese Society of Endocrinology,synthesizes the latest evidence and expert insights to provide evidence-based recommendations for physical activity and exercise therapy in adults with type 2 diabetes(T2D).It is generally recommended that all adult patients with T2D engage in at least 150—300 min of moderate-intensity aerobic exercise per week,or a minimum of75—150 min of vigorous-intensity exercise,or an equivalent combination of moderate-and vigorous-intensity exercise(with a total exercise volume of at least 450 metabolic equivalent-min per week).For patients with T2D who are capable,moderate over-exercise and a combination of different forms of exercise(aerobic,resistance,flexibility,and/or balance training)are encouraged.The guideline also underscores the necessity of targeting specific subgroups of patients with T2D,including the elderly,individuals with obesity or pre-obesity,cardiovascular disease,hypertension,chronic kidney disease,metabolic dysfunction-associated steatotic liver disease,and/or diabetic foot and its high-risk populations.The guideline provides a scientific basis for clinicians to develop personalized exercise guidance and recommendations,with the goal of improving the disease prognosis of the relevant population. 展开更多
关键词 Adult Exercise Physical activity Type 2 diabetes Therapy principle
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Association between Dietary Diversity during Pregnancy and Gestational Diabetes Mellitus:A Prospective Cohort Study 认领 引用 被引量：1
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作者 Weiming Wang Qian Liang +5 位作者 Jin Liu Chenfan Zhang Yuhui Luo Xuefeng Yang Liping Hao Nianhong Yang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第4期418-426,共9页
Objective The study aims to prospectively examine the association between the minimum dietary diversity for women(MDD-W)score and risk of gestational diabetes mellitus(GDM).Methods All participants were pregnant women... Objective The study aims to prospectively examine the association between the minimum dietary diversity for women(MDD-W)score and risk of gestational diabetes mellitus(GDM).Methods All participants were pregnant women enrolled in the Tongji Maternal and Child Health Cohort.Dietary intake was assessed using a food frequency questionnaire(FFQ)or 24-h dietary recall.The MDD-W score was constructed by categorizing all food items into 10 food groups,following the Food and Agriculture Organization guidelines.Oral glucose tolerance tests(OGTT)were conducted during 24−28 weeks of gestation to screen for GDM.Poisson regression models were used to assess the association between MDD-W scores and GDM risk.Results In total,357(11.8%)of the 3,026 women were diagnosed with GDM.Compared with participants whose MDD-W score was≥8,those with a score of 5−7 had an increased risk of GDM(relative risk(RR):1.32;95%confidence interval(CI):1.03,1.69),and those with a score≤4 had a significantly higher GDM risk(RR:1.58;95%CI:1.12,2.26).Furthermore,these findings indicate that pregnant women with MDD-W scores<8,in conjunction with being overweight or obese before pregnancy and excessive gestational weight gain,have the highest risk of developing GDM.Conclusions These data suggest that a higher MDD-W score during pregnancy is independently associated with a lower GDM risk.Therefore,promoting dietary diversity and weight management is recommended to protect pregnant women from developing gestational diabetes. 展开更多
关键词 Dietary diversity Gestational diabetes mellitus Pregnant women Cohort study
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Interplay of childhood metabolic dysfunction-associated steatotic liver disease and obesity in the development of youth-onset type 2 diabetes 认领 引用 被引量：2
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作者 Razieh Parizad Juniali Hatwal +4 位作者 Ajit Singh Brar Leila Alizadeh Manjeet Kumar Goyal Akash Batta Bishav Mohan 《World Journal of Clinical Pediatrics》 2026年第1期232-251,共20页
BACKGROUND The global increase in childhood and adolescent obesity has significantly contributed to the rising prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)–a condition now recognized ... BACKGROUND The global increase in childhood and adolescent obesity has significantly contributed to the rising prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)–a condition now recognized as a key metabolic complication in youth.MASLD significantly increases the risk of youth-onset type 2 diabetes(T2D),particularly among obese individuals.Its asymptomatic progression presents considerable challenges for timely diagnosis and intervention.AIM To review epidemiology,pathophysiological mechanisms,and management strategies related to pediatric MASLD,exploring its interaction with obesity and youth-onset T2D.METHODS A comprehensive literature search was conducted using PubMed,Scopus,and Google Scholar to identify peerreviewed studies published between 2015 and 2025.Keywords included“pediatric MASLD”,“childhood obesity”,“youth-onset type 2 diabetes”,“hepatic insulin resistance”,and“noninvasive biomarkers”.Articles were selected based on relevance,methodological quality,and focus on human pediatric populations.RESULTS MASLD affects approximately 13%of children globally and up to 47%of those with obesity,with the highest prevalence reported in urban areas of the United States,China,and India.In children and adolescents,excess adiposity is the leading contributor to hepatic steatosis and metabolic dysfunction,particularly when body mass exceeds standard growth benchmarks for age and sex.MASLD increases the risk of adolescent T2D by approximately 2.7-fold.Key pathophysiological mechanisms include hepatic insulin resistance,mitochondrial dysfunction,and chronic inflammation,driven by lipotoxic metabolites such as ceramides and pro-inflammatory cytokines.Lifestyle modifications–particularly low free-sugar diets and structured physical activity–have demonstrated moderate efficacy in reducing hepatic fat and improving metabolic outcomes.Pharmacologic interventions,including glucagon-like peptide-1 receptor agonists such as liraglutide and semaglutide,show potential for weight reduction and glycemic control,though their effects on hepatic histology remain under investigation.CONCLUSION MASLD represents a critical metabolic threat in pediatric populations,strongly influenced by obesity and closely associated with increased risk of youth-onset T2D.Effective management requires early detection,multidisciplinary interventions,and equitable access to care.Future research should prioritize the validation of noninvasive diagnostic tools,development of targeted therapies,and reduction of socioeconomic and ethnic disparities in disease burden and treatment outcomes. 展开更多
关键词 Pediatric Metabolic dysfunction-associated steatotic liver disease Childhood obesity Type 2 diabetes mellitus Metabolic syndrome Non-alcoholic fatty liver disease Insulin resistance
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Diabetic ketoacidosis in patients with type 2 diabetes:Risk factors for mortality and adverse outcomes 认领 引用 被引量：1
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作者 Vishnu Chandrabalan Timothy Howcroft +3 位作者 Mohammed Khalid Alkhalifah Noorulanne Younis Ebrahim Aldhafiri Joseph M Pappachan 《World Journal of Experimental Medicine》 2026年第1期161-170,共10页
BACKGROUND Diabetic ketoacidosis(DKA)resulting from type 2 diabetes mellitus(T2DM)is less common,and the factors associated with adverse outcomes and mortality are not well established based on large-scale studies.AIM... BACKGROUND Diabetic ketoacidosis(DKA)resulting from type 2 diabetes mellitus(T2DM)is less common,and the factors associated with adverse outcomes and mortality are not well established based on large-scale studies.AIM To identify the risk factors for adverse outcomes and mortality in treated patients with DKA in T2DM.METHODS Retrospective analysis of patients admitted to a tertiary-care hospital in the United Kingdom with DKA and T2DM for inpatient management between January 2010 to September 2024 to identify the clinical profile,demographic features,and laboratory parameters impacting treatment outcomes and survival.RESULTS Four hundred and sixty-four patients were included.Of these 395(85.13%)were White,266(57.3%)were males with a mean age at presentation of 61.3(17.6)years,median inpatient hospital stay of 5(interquartile range:3-10.3)days,and a mean glycated HbA1c of 89.3(30)mmol/mol.The 30-day and 90-day mortality were 13.4%and 11%respectively after the index DKA event.The long-term survival after the DKA event was only 58.6%.Presence of cerebrovascular disease[odds ratio(OR):6.75;95%CI:0.76-12.74],use of sodium glucose cotransporter 2 inhibitors(OR:5.8;95%CI:1.32-9.62),chronic obstructive pulmonary disease(OR:3.6;95%CI:2.14-6.44),higher national early warning score 2 score(OR:1.14;95%CI:0.10-2.18)and low systolic blood pressure(OR:-0.18;95%CI:-0.32 to-0.04)at admission were the significant predictors of longer inpatient stay.Coexistent peripheral vascular disease(PVD;OR:46.43)and congestive heart failure(CHF;OR:30.83),and lower estimated glomerular filtration rate(eGFR;OR:0.98)were the important predictors of mortality during the hospital treatment.The significant predictors on 30-day mortality were:Age(OR:1.06),eGFR(0.97)and index of multiple deprivation(IMD)decile(0.74).The factors associated with long-term mortality risk were dementia(20.54-fold higher),continued use of sulfonylurea/metformin,and older age(4%higher with each additional year).CONCLUSION DKA carries a serious risk of mortality in both the short and long term in T2DM patients.Factors such as older age,dementia,PVD,CHF,low eGFR define the riskiest groups.These groups of patients may benefit from closer follow-up and more aggressive metabolic and comorbidity management after discharge. 展开更多
关键词 Type 2 diabetes mellitus Diabetic ketoacidosis Dementia Peripheral vascular disease Heart failure Mortality risk
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Metformin fails to prevent diabetes in non-diabetic cardiovascular patients:Systematic review and meta-analysis 认领 引用
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作者 Georgios I Tsironikos George E Zakynthinos +5 位作者 Despoina Kyprianidou Vasiliki Rammou Thomas Antonogiannis Alexandra Bargiota Epaminondas Zakynthinos Vasiliki Tsolaki 《World Journal of Cardiology》 2026年第4期90-102,共13页
BACKGROUND Metformin,a first-line therapy for type 2 diabetes mellitus(T2DM),has demonstrated potential preventive effects in high-risk individuals,especially in those with prediabetes.However,its role in preventing d... BACKGROUND Metformin,a first-line therapy for type 2 diabetes mellitus(T2DM),has demonstrated potential preventive effects in high-risk individuals,especially in those with prediabetes.However,its role in preventing diabetes specifically among non-diabetic patients with established cardiovascular disease(CVD)remains unclear.Given the clinical and public health importance of diabetes prevention in this high-risk group,a systematic evaluation of existing evidence from randomized controlled trials is necessary to inform treatment strategies.AIM To investigate the effectiveness of metformin in preventing T2DM among patients with CVD who do not have diabetes.METHODS We searched PubMed,the Cochrane Central Register of Controlled Trials,and Scopus(from January 1,2000 to July 31,2024)for eligible randomized controlled trials(RCTs).A meta-analysis was conducted to evaluate the effect of metformin on the prevention of T2DM in patients with CVD and or coronary artery disease(CAD)without diabetes.RESULTS A total of 933 patients with CVD,all of whom had CAD,were included(470 in the metformin group and 463 in the control group).Fifty-six participants(11.9%)in the intervention groups and fifty-seven(12.3%)in the control groups developed T2DM.Patients with CAD receiving metformin showed no statistically significant difference in the development of T2DM compared with those not receiving metformin(odds ratio:0.97;95%confidence interval:0.65-1.45;P=0.89).Heterogeneity was rather low(Q=2.38,P=0.50;I2=0%,95%confidence interval:0%-84%),showing satisfactory results across studies;however,the overall quality of evidence was very low.The results remained non-significant in subgroup analyses restricted to:(1)Studies conducted in similar countries;(2)Studies with or without post-intervention follow-up;(3)Studies with a predominance of male or female participants;(4)Studies with a mean participant age above or below 60 years;(5)Studies including central adiposity as an additional diabetes risk factor or not;(6)Studies including prediabetes and/or hypertension as additional risk factors or not;(7)Studies using different daily metformin dosages;and(8)Studies with different intervention durations.CONCLUSION The administration of metformin does not appear to be effective in preventing the development of T2DM in nondiabetic patients with CAD.However,this finding is based on a limited number of small RCTs.Therefore,results should be interpreted cautiously,and further high-quality studies are needed before definitive clinical recommendations can be made. 展开更多
关键词 Metformin Cardiovascular disease Coronary artery disease New onset type 2 diabetes mellitus Diabetes prevention Glucagon-like-peptide-1 receptor agonists Sodium-glucose cotransporter 2 inhibitors Randomized controlled trials
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Metabolic basis of sudden sensorineural hearing loss in diabetes mellitus:From epidemiological association to mechanistic understanding 认领 引用
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作者 Shu-Fen Li Shu-Yue Yu +2 位作者 Yi-Yuan Liu Shu-Cai Fu Yuan-Ping Xiong 《World Journal of Diabetes》 SCIE 2026年第3期90-100,共11页
Sudden sensorineural hearing loss(SSNHL)is an otologic emergency that necessitates prompt intervention;however,its pathogenesis remains elusive in most cases.Diabetes mellitus,a prevalent systemic metabolic disorder,h... Sudden sensorineural hearing loss(SSNHL)is an otologic emergency that necessitates prompt intervention;however,its pathogenesis remains elusive in most cases.Diabetes mellitus,a prevalent systemic metabolic disorder,has been increasingly implicated in the onset and unfavorable prognosis of SSNHL.Although epidemiological studies have consistently reported this association,the biological plausibility and causal direction of this relationship remain poorly understood and require further investigation.This review demonstrated that dysglycemia contributes to hearing impairment.The underlying mechanisms include vascular injury,auditory neuropathy,microcirculatory dysfunction,chronic inflammation driven by oxidative stress,and the accumulation of advanced glycation end products.Microcirculatory dysfunction may act as a critical nexus that integrates these diverse pathological pathways,ultimately leading to hearing loss.The potential role of prediabetes as an early driver of auditory damage,however,remains to be fully elucidated.Current management of SSNHL involves the use of glucocorticoids,vasodilators,neurotrophic agents,and adjunctive therapies,such as hyperglycemic control and hyperbaric oxygenation.Strengthening basic and translational research is essential to bridge mechanistic insights with clinical practice to develop precise therapeutic strategies to improve outcomes for patients with diabetes mellitus or prediabetes who present with SSNHL. 展开更多
关键词 Sudden sensorineural hearing loss Diabetes mellitus Prediabetes Mechanisms Dysglycemia
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Diabetes:A comprehensive review of the Indian landscape in contrast with global trends 认领 引用
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作者 Nidhi Singh Rana Naveen Kumar Vishvakarma +1 位作者 Subash Chandra Sonkar Mirza Masroor Ali Beg 《World Journal of Diabetes》 SCIE 2026年第2期14-39,共26页
In recent years,diabetes has become a major global health concern,and India is one of the countries most affected by the growing number of cases.In this review,we explore the diabetes scenario in the Indian community ... In recent years,diabetes has become a major global health concern,and India is one of the countries most affected by the growing number of cases.In this review,we explore the diabetes scenario in the Indian community in comparison with global patterns.The extensive literature on diabetes suggests that poor diet,sedentary lifestyles,and genetic predisposition have been risk factors for diabetes.We further discuss disease management and treatment strategies related to diabetes in India,highlighting the challenges in healthcare accessibility and affordability.In addition,particularly in Indian scenarios,the role of traditional medicine as an alternative medicine is also discussed.This overall highlights possible interventions,including the National Diabetes Control Program,telehealth advancements,and community-based awareness campaigns.Therefore,we aim to discuss potential scenarios like rapid urbanization,changing dietary patterns,and socio-economic disparities in the diabetes epidemic in the country,and practical solutions for overall diabetes outcomes. 展开更多
关键词 Diabetes Disease management Indian community India’s epidemic condition Global health concern Disease management Diabetes epidemic
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Monogenic diabetes:An evidence-based clinical approach 认领 引用 被引量：2
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作者 Saptarshi Bhattacharya Cornelius J Fernandez +1 位作者 Abul Bashar Mohammad Kamrul-Hasan Joseph M Pappachan 《World Journal of Diabetes》 SCIE 2025年第5期47-70,共24页
Monogenic diabetes is a heterogeneous disorder characterized by hyperglycemia arising from defects in a single gene.Maturity-onset diabetes of the young(MODY)is the most common type with 14 subtypes,each linked to spe... Monogenic diabetes is a heterogeneous disorder characterized by hyperglycemia arising from defects in a single gene.Maturity-onset diabetes of the young(MODY)is the most common type with 14 subtypes,each linked to specific mutations affecting insulin synthesis,secretion and glucose regulation.Common traits across MODY subtypes include early-onset diabetes,a family history of autosomal dominant diabetes,lack of features of insulin resistance,and absent islet cell autoimmunity.Many cases are misdiagnosed as type 1 and type 2 diabetes mellitus.Biomarkers and scoring systems can help identify candidates for genetic testing.GCK-MODY,a common subtype,manifests as mild hyperglycemia and doesn’t require treatment except during pregnancy.In contrast,mutations in HNF4A,HNF1A,and HNF1B genes lead to progressive beta-cell failure and similar risks of complications as type 2 diabetes mellitus.Neonatal diabetes mellitus(NDM)is a rare form of monogenic diabetes that usually presents within the first six months.Half of the cases are lifelong,while others experience transient remission.Permanent NDM is most commonly due to activating mutations in genes encoding the adenosine triphosphate-sensitive potassium channel(KCNJ11 or ABCC8)and can be transitioned to sulfonylurea after confirmation of diagnosis.Thus,in many cases,monogenic diabetes offers an opportunity to provide precision treatment.The scope has broadened with next-generation sequencing(NGS)technologies,replacing older methods like Sanger sequencing.NGS can be for targeted gene panels,whole-exome sequencing(WES),or whole-genome sequencing.Targeted gene panels offer specific information efficiently,while WES provides comprehensive data but comes with bioinformatic challenges.The surge in testing has also led to an increase in variants of unknown significance(VUS).Deciding whether VUS is disease-causing or benign can be challenging.Computational models,functional studies,and clinical knowledge help to determine pathogenicity.Advances in genetic testing technologies offer hope for improved diagnosis and personalized treatment but also raise concerns about interpretation and ethics. 展开更多
关键词 Monogenic diabetes Maturity-onset diabetes of the young Neonatal diabetes Mitochondrial diabetes Insulin resistance syndrome Monogenic autoimmune diabetes Next-generation sequencing
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Inadequate glycemic control among patients with type 2 diabetes in Jordan:prevalence and associated factors 认领 引用
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作者 Abeer Amin Mohammad Jafar Alshraideh +1 位作者 Mohammed Ibrahim Yacoub Mohammad A.Abu Sabra 《Frontiers of Nursing》 2026年第1期131-138,共8页
Background:Diabetes mellitus(DM)is a chronic illness with potentially fatal and debilitating consequences.Problems with glycemic management are a major issue that adds an added strain to public health services.Objecti... Background:Diabetes mellitus(DM)is a chronic illness with potentially fatal and debilitating consequences.Problems with glycemic management are a major issue that adds an added strain to public health services.Objectives:The purpose of this study is to evaluate the prevalence of poor glycemic control and its related variables among type 2 diabetes mellitus(T2DM)patients in southern Jordan.Methods:A cross-sectional study was carried out in the Prince Hashem bin Abdullah II Hospital in Jordan's southernmost province.For the period April–July 2024,516 individuals with T2D were enrolled.A structured questionnaire that had been pre-prepared was used to collect data.As an index of glycemic control,a glycated hemoglobin(Hb A1c)7%cut-off point was adopted.Results:Poor glycemic control was prevalent in 81.0%of T2DM individuals.Inadequate glycemic control was significantly worse in non-married patients and those with 10 or more years of diabetes duration,insulin treatment,dyslipidemia,neuropathy,cardiovascular illness,and glomerular filtration rate(GFR=60 m L/min;[P<0.05]).Moreover,dyslipidemia and insulin administration increased the likelihood of poor glycemic control(odds ratio[OR]:2 and 5,respectively)(P<0.05).Conclusions:Inadequate glycemic control was common among the current study par ticipants.To prevent disease consequences and enhance the health of patients with diabetes,health care professionals should pay special attention to related risk factors such as dyslipidemia,neuropathy,cardiovascular disease(CVD),extended illness duration,and insulin usage. 展开更多
关键词 diabetes management glycemic control Jordan type 2 diabetes
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Review of diabetes education intervention targeting parent/caregiver of children with type 1 diabetes 认领 引用
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作者 Ola Hasoneh Jafar A.Alshraideh Diana H.Arabiat 《Frontiers of Nursing》 2026年第1期15-23,共9页
Objective:This review aimed to evaluate existing evidence of educational interventions targeted at parents and caregivers of children with type 1 diabetes(T1D)to improve diabetes management outcomes.Methods:A general ... Objective:This review aimed to evaluate existing evidence of educational interventions targeted at parents and caregivers of children with type 1 diabetes(T1D)to improve diabetes management outcomes.Methods:A general review was conducted with primary caregivers of children younger than 18 with T1D as the population of interest.Journal searches were performed using the CINAHL,EBSCO,Pub Med,Scopus,Science Direct,and Google Scholar,databases for publications between 2017 and 2024,with full text in English.Results:A total of 26 studies were included in the review.Nine of these studies focused on various educational interventions,both technology-based and non-technology-based.By contrast,17 studies examined the impact of these interventions on caregiver outcomes,such as treatment adherence and glycemic control in children with T1D.So,the following research questions guided this review:(1)What is the effectiveness of diabetes education interventions on glycemic control in children with T1D?(2)How do caregiver knowledge and self-efficacy affect diabetes management outcomes?Conclusions:Diabetes interventions highlight the vital role of empowering caregivers of children with T1D with knowledge,skills,and support to improve and enhance their adherence to treatment,knowledge,and self-efficacy that ultimately contribute to better glycemic control of children as reflected by their Hb A1c levels.This review highlights the importance of diabetes education interventions for caregivers of children with T1D.The evidence indicates that such interventions can improve caregiver knowledge,self-efficacy,and glycemic control in children.However,variability in outcomes suggests that fur ther research is needed to identify the most effective educational strategies. 展开更多
关键词 caregivers children diabetes management glycemic control intervention structured education Type 1 diabetes mellitus
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Prevalence and clinical characteristics of chronic kidney disease among patients with newly diagnosed ketosis-onset diabetes 认领 引用 被引量：1
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作者 Meng-Han Li Man-Rong Xu +3 位作者 Yu-Jie Wang Li Shen Ming-Yun Chen Lian-Xi Li 《World Journal of Diabetes》 SCIE 2025年第3期115-124,共10页
BACKGROUND The prevalence and clinical characteristics of chronic kidney disease(CKD)among patients with ketosis-onset diabetes(also known as ketosis-prone diabetes)remain unclear.Furthermore,the classification of ket... BACKGROUND The prevalence and clinical characteristics of chronic kidney disease(CKD)among patients with ketosis-onset diabetes(also known as ketosis-prone diabetes)remain unclear.Furthermore,the classification of ketosis-onset diabetes remains controversial and requires further investigation.AIM To investigate the prevalence and clinical features of CKD in patients with newly diagnosed ketosis-onset diabetes.METHODS This real-world study included 217 patients with type 1 diabetes mellitus(T1DM),698 with ketosis-onset diabetes,and 993 with non-ketotic T2DM.The prevalence and clinical characteristics of CKD were compared among the three groups.Risk factors associated with CKD were evaluated using binary logistic regression for each group.RESULTS After adjusting for age and sex,the prevalence of CKD among patients with ketosis-onset diabetes(17.8%)was significantly higher than that in those with T1DM(8.3%,P=0.007),but was not statistically different compared to those with non-ketotic T2DM(21.7%,P=0.214).Furthermore,some risk factors for CKD,including age,and serum uric acid and C-reactive protein levels,in patients with ketosis-onset diabetes were similar to those with T2DM,but significantly different from those with T1DM.CONCLUSION The prevalence,clinical characteristics,and risk factors for CKD among patients with ketosis-onset diabetes were more similar to those with non-ketotic T2DM but considerably different from those with T1DM.These findings further support the classification of ketosis-onset diabetes as a subtype of T2DM rather than idiopathic T1DM. 展开更多
关键词 Ketosis-onset diabetes Ketosis-prone diabetes Type 1 diabetes mellitus Type 2 diabetes mellitus Chronic kidney disease Diabetic nephropathy
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A meta-analysis based on epidemiological studies to identify the key environmental pollutants inducing gestational diabetes mellitus 认领 引用
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作者 Yun Deng Shujun Yi +3 位作者 Chi Zhang Rongyan Yang Wenjue Zhong Lingyan Zhu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期468-478,共11页
Exposure to environmental pollutants intricately contributes to the incidence of gestational diabetes mellitus(GDM),thus it is imperative to identify the key contaminants which may induce GDM risk in humans.Herein,we ... Exposure to environmental pollutants intricately contributes to the incidence of gestational diabetes mellitus(GDM),thus it is imperative to identify the key contaminants which may induce GDM risk in humans.Herein,we conducted a systematic review and meta-analysis on a total of 112 epidemiological studies to clarify the environmental risk factors for GDM occurrence.A total of 10 air pollutants,26 metal elements,and 8 categories of organic compounds were examined.Fixed-and random-effect models were used to calculate the pooled odds ratio and 95%confidence interval for evaluating the effects of contaminants.The results showed that exposure to air pollutants significantly increased GDM risk,with black carbon,PM2.5,PM10,carbon monoxide,nitric oxide,nitrogen oxides,and sulfur dioxide identified as potential risk factors(p<0.05).There was a markedly positive relationship between metal exposure and GDM risk,with aluminum,antimony,mercury,and rubidium contributing significantly to GDM incidence(p<0.05).Higher exposure to organic compounds was also associated with a greater risk of GDM,with polybrominated diphenyl ethers,per-and poly-fluoroalkyl substances(PFAS),phthalates,polychlorinated biphenyls,and organophosphate esters making significant contributions(p<0.05).Several specific homologues were identified to make a dominant contribution within each class of these organic chemicals,such as perfluorooctanoic acid(36.54%)and perfluorononanoic acid(32.09%),which were the most risky PFAS compounds.These findings provide a critical insight into the etiology of GDM and may inform strategies to protect against pregnancy complications. 展开更多
关键词 Environmental pollutants Gestational diabetes mellitus Epidemiological studies Risk factors Meta-analysis
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Honokiol attenuates diabetes by enriching Akkermansia muciniphila andregulating tryptophan metabolism in mice 认领 引用
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作者 Yang Lin Zhengmeng Jiang +7 位作者 Zhilu Yu Tianqing Huang Wanyu Gui Ziyuan Wang Fei Li Pingting Xiao Changyin Li Ehu Liu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期59-72,共14页
Diabetes mellitus(DM)is a chronic disease influenced by gut microbiome disturbances.Honokiol(HON),a low oral bioavailability compound from Magnolia officinalis bark,has demonstrated potential as a treatment for DM.Thi... Diabetes mellitus(DM)is a chronic disease influenced by gut microbiome disturbances.Honokiol(HON),a low oral bioavailability compound from Magnolia officinalis bark,has demonstrated potential as a treatment for DM.This research investigates the effects of HON on gut microbiota and host metabolism to elucidate its mechanism of action in DM.After 8 weeks of intervention through fecal microbiota transplantation(FMT)or antibiotic treatment,HON improved glucose tolerance and lipid metabolism in a gut microbiota-dependent manner.Specifically,HON administration significantly increased Akkermansia muciniphila(AKK)abundance and modulated tryptophan(TRP)metabolism,as evidenced by 16S ribosomal ribonucleic acid(rRNA)gene sequencing and untargetedargeted metabolomics analysis.Notably,research revealed that AKK metabolized TRP into tryptamine(TA)and other metabolites in vitro.Both AKK and TA activated the aryl hydrocarbon receptor(AHR)pathway,increasing circulating glucagon-like peptide-1(GLP-1)levels and ameliorating diabetes-related symptoms in DM mice.These findings indicate that HON’s hypoglycemic effect primarily stems from AHR-GLP-1 pathway activation through targeted modulation of AKK and microbial TRP metabolite TA,potentially enhancing HON’s clinical applications. 展开更多
关键词 Honokiol Diabetes mellitus Akkermansia muciniphila Tryptamine Aryl hydrocarbon receptor
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Early diabetes-like phenotypes in germ-free mice induced by gut microbiota from patients with type 2 diabetes 认领 引用
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作者 Jianghao Feng Xing Liu +4 位作者 Hua Zhu Yun Yang Wei Liu Xiaoliang Jiang Zhiwei Yang 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第6期1202-1216,共15页
Background:The contribution of gut microbiota to the early stage of type 2 diabetes(T2D)remains incompletely understood.This study established a germ-free mouse model colonized with gut microbiota from donors with T2D... Background:The contribution of gut microbiota to the early stage of type 2 diabetes(T2D)remains incompletely understood.This study established a germ-free mouse model colonized with gut microbiota from donors with T2D to determine whether diabetes-associated microbiota could induce early diabetes-like phenotypes.Methods:Human fecal samples were collected from 18 healthy donors and 14 donors with T2D for microbiota profiling.Based on these features,samples from 12 healthy donors and 3 donors with T2D were selected,pooled within each group,and transplanted into germ-free mice,generating a healthy microbiota recipient group(HM,n=14)and a diabetes-associated microbiota recipient group(DM,n=13).Glucose homeostasis was assessed over 10 weeks using fasting blood glucose and intraperitoneal glucose tolerance tests.Gut microbial succession was analyzed by 16S rRNA sequencing.Fecal and plasma metabolomics were performed to identify metabolic and their associations with microbial changes.Results:DM mice developed an early diabetes-like phenotype characterized by progressive impairment of glucose tolerance,reduced insulin levels,and mild renal alterations,without sustained overt fasting hyperglycemia.Microbial divergence emerged before stable metabolic dysfunction and was accompanied by persistent dysbiosis in DM mice.Integrated metabolomic analysis identified coordinated alterations in fecal and plasma metabolites,with cholic acid and L-Dopa decreased in both compartments.L-Dopa showed consistent associations with altered genera,particularly Ruminococcus and Sellimonas.Conclusions:Transplanting diabetes-associated human gut microbiota effectively induced early glucose dysregulation in germ-free recipient mice.This model provides a framework for studying microbiota-associated events during early T2D-related metabolic deterioration. 展开更多
关键词 germ-free mice metabolomics microbiomics microbiota transplantation type 2 diabetes
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Identification and verification of key genes related to oxidative stress in type 2 diabetes and screening of candidate drugs from Traditional Chinese Medicine 认领 引用
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作者 HU Jingnan LIAO Man +3 位作者 XI Zhongwen SONG Jing WANG Yining HE Tao 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第2期350-359,共10页
OBJECTIVE:To identify oxidative stress(OS)-related genes involved in type 2 diabetes mellitus(T2DM)and screen potential Traditional Chinese Medicine(TCM)candidates for therapeutic use.METHODS:Gene expression data from... OBJECTIVE:To identify oxidative stress(OS)-related genes involved in type 2 diabetes mellitus(T2DM)and screen potential Traditional Chinese Medicine(TCM)candidates for therapeutic use.METHODS:Gene expression data from the GSE23343 dataset were obtained from the Gene Expression Omnibus(GEO)database.Differentially expressed genes(DEGs)between healthy and T2DM patients were identified.Weighted gene co-expression network analysis(WGCNA)was performed to select modules highly correlated with clinical traits,and core genes within these modules were identified.OS-related genes were retrieved from the Gene Cards database,and the overlapping DEGs,WGCNA genes,and OS-related genes were considered as hub genes in OS-related T2DM.These hub genes were validated in GSE15653 dataset.Potential TCMs were identified by mapping the hub genes to the Coremine Medical database.In vivo validation was performed using a T2DM rat model established by a high-fat diet and streptozotocin injection.The effects of Wedelolactone were evaluated by assessing gene expression via real-time quantitative reverse transcription PCR(q RT-PCR)and Western blot,alongside metabolic and liver function parameters,including fasting blood glucose,glycated serum protein,insulin resistance,and lipid profiles.RESULTS:A total of 394 DEGs(136 up-regulated and 258 down-regulated DEGs.)were identified in the GSE23343 cohort.WGCNA results showed that the turquoise module(cor=-0.56,P=0.02)and the brown module(cor=0.66,P=0.004)were the most correlated with T2DM.Six hub genes[interleukin 33(IL33),S100 calcium binding protein A8(S100A8),Golgi membrane protein 1(GOLM1),small nuclear ribonucleoprotein U1 subunit 70(SNRNP70),hepatocyte growth factor activator(HGFAC),and oxidative stress induced growth inhibitor 1(OSGIN1)]were identified,with IL33,S100A8,and GOLM1 being up-regulated,and SNRNP70,HGFAC,and GOLM1 being down-regulated.These genes distinguished T2DM from healthy controls with AUC values greater than 0.8.Experimental verification using a T2DM rat model confirmed the expression patterns of the hub genes.In vivo data demonstrated that Wedelolactone significantly reduced oxidative stress,inflammation hepatic lipid accumulation,and improved metabolic parameters such as fasting blood glucose,glycated serum protein,and insulin resistance.CONCLUSION:These findings highlight the critical roles of IL33,S100A8,GOLM1,SNRNP70,HGFAC,and OSGIN1 as biomarkers in OS-related T2DM and suggest that Wedelolactone may be a promising TCM-based therapeutic candidate for T2DM. 展开更多
关键词 diabetes mellitus,type 2 oxidative stress gene expression profiling computational biology medicine,Chinese traditional Wedelolactone
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