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Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen 认领 引用 被引量：1
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作者 Bhagyalakshmi Nair Rajesh Gopalakrishna Lekshmi R Nath 《World Journal of Hepatology》 2026年第5期234-243,共10页
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)ranges from simple steatosis to cirrhosis and liver cancer,with rising prevalence in India due to high fat,high sugar diets.Kaempferol,a genera... BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)ranges from simple steatosis to cirrhosis and liver cancer,with rising prevalence in India due to high fat,high sugar diets.Kaempferol,a generally recognized as safe-certified flavonoid found in fruits and vegetables with anti-inflammatory,antioxidant,and lipid-lowering properties.Despite its therapeutic promise,kaempferol’s efficacy remains unexplored in Indian diet-based obesity liver disease models.Developing such models could support targeted dietary interventions for the Indian population at elevated risk for MASLD progression.AIM To evaluate effect of kaempferol in C57BL/6J mice using an Indian diet-mimicking experimental animal model.METHODS Male C57BL/6J mice(6 weeks to 8 weeks,n=3/group)were fed a normal diet or an Indian high fat diet(HFD)with fructose for 8.5 weeks,followed by kaempferol(50 mg/kg)or vitamin E(500 mg/kg)every other day for 4 weeks.Body weight,diet intake,liver function,and histopathology were evaluated.Liver samples were examined using hematoxylin and eosin staining.The non-alcoholic fatty liver disease score was assessed using the non-alcoholic steatohepatitis clinical research network criteria.The serum transforming growth factor beta 1 was detected using enzyme-linked immunosorbent assay kit.Additionally,the study also involves proximate and mineral composition of the diet for its validation.Moreover,the effect of kaempferol was further evaluated using an ex vivo precision-cut liver slice model.RESULTS We formulated a high calorie experimental HFD mimicking the Indian diet regimen(Indian HFD prepared and standardized in our lab and a provisional patent is filed),which shows an elevated crude fat and reduced crude fiber,ash,and moisture compared to the control feed.Mice fed this diet shows significant weight gain and hepatic steatosis,with macro-vesicular and micro-vesicular fat and lobular inflammation.Non-alcoholic fatty liver disease scoring confirms an increased steatosis and inflammation and also,transforming growth factor beta 1 levels were significantly elevated in the Indian HFD group.Kaempferol treatment significantly reduces body weight,steatosis,and inflammation.In ex vivo precision-cut liver slice models,kaempferol improved liver function enzymes and reduced hepatic triglycerides level.CONCLUSION Kaempferol improved hepatic steatosis and liver parameters in a diet-induced MASLD model mimicking the Indian diet,showing promising therapeutic potential. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease Indian high fat diet High calorie diet Natural product Kaempferol Hepatic steatosis
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Association of Planetary Health Diet with Decreased Risk of All-cause Mortality and Environmental Benefits:Insights from a Multi-national Prospective Cohort Study 认领 引用
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作者 Xi Li Liyuan Tao Jue Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第4期476-481,共6页
Whether adherence to the Planetary Health Diet(PHD)benefits human and environmental health is less known.We included 131,130 adults from the National Health and Nutrition Examination Survey and UK Biobank.Adherence to... Whether adherence to the Planetary Health Diet(PHD)benefits human and environmental health is less known.We included 131,130 adults from the National Health and Nutrition Examination Survey and UK Biobank.Adherence to the PHD was measured using the Planetary Health Diet Index(PHDI)and mortality was ascertained by linking to national registries.Cox proportional hazards and linear/ordinal logistic regression models were used to analyze the association between PHD and the risk of mortality and environmental impacts,respectively. 展开更多
关键词 environmental benefits multi national prospective cohort study UK Biobank linking national registriescox proportional hazards mortality planetary health diet planetary health diet phd benefits National Health Nutrition Examination Survey
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The Mediterranean diet as a potential strategy for mitigating the intake and exposure to contaminants resulting from food processing 认领 引用
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作者 Daniel Hinojosa-Nogueira Cristina María Díaz-Perdigones +8 位作者 Alba Subiri-Verdugo Alba Rodríguez-Muñoz María José García-López María Rosa Bernal-López Montse Fitó Jordi Salas-Salvadó Miguel Ángel Martínez-González Francisco J.Tinahones Isabel Moreno-Indias 《Emerging Contaminants》 CSCD 2026年第2期124-132,共9页
Dietary intake represents a significant route of exposure to chemical contaminants,including compounds formed during the food processing.The present study estimated the intake and exposure to 11 food contaminants in a... Dietary intake represents a significant route of exposure to chemical contaminants,including compounds formed during the food processing.The present study estimated the intake and exposure to 11 food contaminants in adults with metabolic syndrome.The changes during a Mediterranean diet(MedDiet)based intervention were also evaluated.The present investigation included 225 participants from one of the Málaga centers of the PREDIMED-Plus trial(2013-2016).The dietary intake was assessed through the implementation of a validated food frequency questionnaire,and adherence to the Mediterranean diet was determined using a screener tool comprising 17 items.Contaminant concentrations were obtained from the CONT11 database and linked to reported food consumption.The findings,based on an average follow-up period of two years,revealed a decline in both weight and body mass index,with a simultaneous increase in adherence to the MedDiet.The intervention arm exhibited a more pronounced enhancement in adherence to MedDiet.The estimated intake and exposure of most contaminants declined,except for nitrates and total polycyclic aromatic hydrocarbons,which increased.Furosine,pyrraline and Amadori compounds were directly associated with body mass index and waist circumference,while MedDiet adherence was inversely associated with estimated exposure to these contaminants.These findings are consistent with the hypothesis that a dietary intervention focused on MedDiet may reduce estimated dietary exposure to several contaminants derived from processing,while simultaneously improving anthropometric outcomes.Notwithstanding the necessity for future validation of these estimates against biomarkers,this scalable approach is especially well suited to nutritional epidemiology in large cohorts. 展开更多
关键词 Food contaminants Dietary exposure Mediterranean diet Anthropometric measurements Diet adherence Food safety
Ketogenic diet,cardiometabolic diseases and aging 认领 引用
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作者 Giuseppe Cioffi Gianluigi Cuomo +7 位作者 Raffaele Carluccio Crescenzo Testa Anna Di Lorenzo Luigi De Vito Valentina Parisi Maddalena Conte Dario Leosco Francesco Giallauria 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第5期275-283,共9页
The ketogenic diet(KD),characterized by a high-fat,moderate-protein,and low-carbohydrate macronutrient composition,has gained growing interest as a potential nutritional approach to cardiometabolic diseases and aging.... The ketogenic diet(KD),characterized by a high-fat,moderate-protein,and low-carbohydrate macronutrient composition,has gained growing interest as a potential nutritional approach to cardiometabolic diseases and aging.Emerging evidence suggests that ketone bodies,particularlyβ-hydroxybutyrate,act not only as alternative energy substrates but also as signaling molecules that influence vascular,metabolic,and epigenetic pathways.This review summarizes current knowledge on the cardiovascular and metabolic implications of KD,emphasizing endothelial function,cardiac energy metabolism,lipid profile,and blood pressure regulation.Experimental and clinical data indicate that KD enhances endothelial antioxidant capacity via Nrf2 activation and e NOS upregulation,reduces cellular senescence,and modulates epigenetic regulators such as histoneβ-hydroxybutyrylation and SIRT1.In heart failure,acute ketone supplementation improves cardiac output and energetics,while chronic adherence to KD may impair hepatic ketogenesis and lipid homeostasis,potentially offsetting its benefits.Evidence in hypertension and dyslipidemia remains controversial,with short-term improvements often contrasted by long-term elevations in LDL cholesterol and arterial stiffness.In patients with type 2 diabetes,KD promotes glycemic control and insulin sensitivity,yet the sustainability and cardiovascular safety of prolonged use are uncertain.Overall,KD represents a promising but complex therapeutic tool whose efficacy depends on individual metabolic context,diet composition,and duration.A balanced,intermittent,or cyclic ketogenic approach may offer a safer strategy to harness its cardiometabolic and anti-aging benefits. 展开更多
关键词 ketone bodiesparticularly hydroxybutyrateact ketogenic diet kd characterized ketogenic diet alternative energy substrates cardiometabolic diseases nutritional approach cardiovascular metabolic implicat aging
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High-protein diets and metabolic dysfunction-associated steatotic liver disease: A double-edged sword in liver health 认领 引用
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作者 Hong-Yuan Yin Qian-Hui You +2 位作者 Wei-Jie Zhang Guang Ji Yan-Qi Dang 《World Journal of Gastroenterology》 SCIE CAS 2026年第6期15-29,共15页
Metabolic dysfunction-associated steatotic liver disease(MASLD)is among the most prevalent chronic liver conditions globally and is closely linked with a range of metabolic disorders.Recently,the high-protein diet(HPD... Metabolic dysfunction-associated steatotic liver disease(MASLD)is among the most prevalent chronic liver conditions globally and is closely linked with a range of metabolic disorders.Recently,the high-protein diet(HPD)has garnered attention for its potential benefits in weight management and metabolic health;however,its impact on MASLD remains a subject of debate.This article provided a systematic review of epidemiological studies,clinical trials,and foundational research concerning the role of HPD in MASLD.It examined the mechanisms by which HPD influences liver metabolism,inflammatory responses,and gut microbiota in patients with MASLD and assessed their clinical efficacy.The review revealed that HPD exerts dual effects on MASLD,contingent upon the protein source and consumption levels,and plant-based proteins conferred metabolic advantages.Therefore,it is advised that patients with MASLD prioritize plantbased proteins while moderating animal protein intake.Future research should aim to elucidate the mechanisms underlying HPDs and deploy personalized nutrition approaches that integrate genomic,proteomic,metabolomic,and microbiome profiles to predict individual responsiveness to specific protein sources,thereby enabling precision dietary algorithms for MASLD prevention and treatment. 展开更多
关键词 High-protein diets Metabolic dysfunction-associated steatotic liver disease Diet Mechanism Clinical trial
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Optimization and verification of high-fat diet formulation for establishing a rat model of obesity-related precocious puberty 认领 引用
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作者 Jiayi Gong Wei Qian +3 位作者 Deji Song Kang Li Li Zhang Li Shi 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第3期453-461,共9页
Childhood obesity is closely linked to the rising incidence of precocious puberty(PP),yet valid preclinical models of obesity-related PP remain lacking.High-fat diets(HFD)are widely used for obesity models,but the sui... Childhood obesity is closely linked to the rising incidence of precocious puberty(PP),yet valid preclinical models of obesity-related PP remain lacking.High-fat diets(HFD)are widely used for obesity models,but the suitability of different HFD formulations for inducing PP is unknown.Female Sprague-Dawley(SD)rats were randomized to control,45%HFD,or 60%HFD groups at postnatal day(PND)21.Body weight and daily caloric intake were monitored;vaginal opening(VO)was recorded from PND 35.At study termination,serum levels of estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),gonadotropin-releasing hormone(GnRH),leptin,and adiponectin were measured.Ovarian histology and vaginal cytology were assessed.In vitro,GT1-7 cells were treated with recombinant mouse leptin for 24 h,and GnRH secretion was quantified.Compared to controls and the 60%HFD group,rats fed 45%HFD exhibited significantly increased body weight,earlier VO onset,and elevated weights of organs.The 45%HFD group also had higher serum E2,LH,FSH,GnRH,and leptin levels,alongside reduced adiponectin;ovarian histology showed advanced follicular development,and vaginal smears displayed estrus-stage cytology.In con-trast,the 60%HFD group had no significant changes in body weight or hormonal parameters,and limited ovarian development.In vitro,leptin treatment significantly upregulated GnRH secretion in GT1-7 cells.The 45%HFD formulation is optimal for constructing a juvenile rat model of obesity-related PP,as it recapitulates key pheno-typic,histological,and endocrine features of the disease. 展开更多
关键词 diet-induced obesity gonadotropin-releasing hormone high-fat diet leptin precocious puberty
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Dietary nitrate drives gastritis by modulating gastric microbiota and metabolites 认领 引用
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作者 Lanping Jiang Tianhui Li +10 位作者 Jiayu Wu Harry Cheuk Hay Lau Chi Chun Wong Xingyu Zhou Alvin Ho Kwan Cheung Qinyao Wei Jing Ren Xiang Zhang Qing Li Yongzhan Nie Jun Yu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第5期717-736,共20页
Objective:Dietary nitrate has been increasingly recognized as a potential carcinogen associated with gastritis.In this study the mechanistic role of a high-nitrate diet(NaD)in driving gastritis was elucidated with a f... Objective:Dietary nitrate has been increasingly recognized as a potential carcinogen associated with gastritis.In this study the mechanistic role of a high-nitrate diet(NaD)in driving gastritis was elucidated with a focus on modulation of the gastric microbiota composition and metabolomic profiles.Methods:Animals were randomly assigned to two dietary intervention groups using a C57BL/6 mouse model:a NaD containing 7.5%nitrate;or a standard normal diet(ND).Gastric microbiota composition was characterized based on full-length 16S rRNA sequencing and gastric metabolite profiles were analyzed using high-performance liquid chromatography-mass spectrometry(HPLC/MS).Finally,the roles of the microbiome and metabolites in gastritis development were validated using the human gastric epithelial cell line(GES-1),as well as conventional and germ-free mouse models.Results:NaD induced gastritis in conventional mice compared to ND-fed mice.In addition,NaD incited the infiltration of macrophages and neutrophils with elevated levels of inflammatory cytokine genes(IL-17a,Ccl20,Cxcl5,IL-6,and Ccl2).A significant shift in the composition of the gastric microbiota occurred with an increase in pathogenic bacteria(Enterococcus gallinarum,Prevotella timonensis,and Mycobacterium gordona)and a decrease in probiotics(Roseburia hominis,Clostriduim scindens,and Faecalibacterium prausnitzii).Furthermore,NaD induced alterations in the metabolic profile,marked by an elevated level of 5-hydroxyindoleacetate(5-HIAA),a key downstream metabolite of the tryptophan metabolic pathway.Notably,5-HIAA also upregulated the levels of inflammatory cytokines in the human gastric epithelial GES-1 cell line.In addition,both E.gallinarum colonization and 5-HIAA exposure significantly increased inflammatory responses in conventional and germ-free mouse models.Conclusions:NaD drives gastritis in mice by inducing gastric microbial dysbiosis and metabolomic dysregulation with elevated 5-HIAA. 展开更多
关键词 Nitrate diet gastritis Enterococcus gallinarum 5-HIAA germ-free mouse
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Protective effects of vine tea on high-fat diet rat:regulation of ferroptosis pathway and gut microbiota 认领 引用
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作者 Zhu Tao Junye Li +6 位作者 Pinrong Qian Guodong Wu Kexin Hu Yihan Wen Xie He Chunhua Fu Longjiang Yu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期381-394,共14页
Vine tea is documented in ancient Chinese books as having the function of promoting blood circulation.However,its effects and mechanisms remain unclear.The aim of this study was to comprehensively investigate the prot... Vine tea is documented in ancient Chinese books as having the function of promoting blood circulation.However,its effects and mechanisms remain unclear.The aim of this study was to comprehensively investigate the protective potential and mechanisms of vine tea in high-fat diet rat through a combination of in vivo and in vitro experiments.The efficacy of vine tea was evaluated using a high-fat diet rat model and an oxidized low-density lipoprotein-treated cell model,with physiological and biochemical indicators measured in rat serum and cell supernatants.Transcriptomics was utilized to investigate alterations mRNA expression following the administration of dihydromyricetin in cell model.Metabolomics and 16S rRNA sequencing was employed to examine changes in metabolites in the serum and changes in gut microbiota of high-fat diet rats after administering vine tea extract.Vine tea extract and dihydromyricetin can reduce elevated levels of lipids,including total cholesterol and triglycerides,following modeling.Transcriptomic data indicate that dihydromyricetin exerts its effects by regulating ferroptosis signaling pathways.Metabolomic analysis demonstrates that the administration of vine tea extract influences the vitamin K cycle and glutathione,thereby alleviating the progression of ferroptosis.Additionally,16S rRNA sequencing reveals that vine tea extract increases Lactobacillaceae in the gut microbiota,which subsequently affects the levels of lysophosphatidylcholine,a major phospholipid component of oxidized low-density lipoprotein in serum.Our results indicate that vine tea can regulate ferroptosis signaling pathways and increase Lactobacillaceae in the gut microbiota,thereby exhibiting cardiovascular protective effects in high-fat diet rats. 展开更多
关键词 Vine tea Dihydromyricetin High-fat diet rat Ferroptosis Lactobacillaceae
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A high-fat diet rescues muscle atrophy by restoring adiponectin and attenuating systemic inflammation in cachectic mice 认领 引用
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作者 Yida Wang Yannan Guo +5 位作者 Huan Peng Nan Long Qingfei Liu Ying Qiu Xue Li Zhao Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3116-3127,共12页
Cancer cachexia is a multifactorial syndrome characterized by progressive muscle and fat loss,driven by systemic inflammation and metabolic dysfunction.The role of adipose tissue in modulating muscle wasting through e... Cancer cachexia is a multifactorial syndrome characterized by progressive muscle and fat loss,driven by systemic inflammation and metabolic dysfunction.The role of adipose tissue in modulating muscle wasting through endocrine signaling remains underexplored.This study investigates the therapeutic potential of a high-fat diet(HFD)in mitigating muscle atrophy in cancer cachexia through adiponectin signaling.Lewis lung carcinoma(LLC)cells(1.5×106cells per mouse)were subcutaneously implanted in C57BL/6J mice to induce cachexia.Mice were randomized to receive either a standard diet(CD)or an HFD(65%energy from fat)for 21 days post-tumor implantation.Serum and tissue samples were analyzed for inflammatory markers,muscle mass,adiponectin expression,and muscle function using enzyme-linked immunosorbent assay(ELISA),quantitative real-time PCR(qRT-PCR),hematoxylin-eosin(H&E)staining,and functional assays.The HFD did not affect tumor size or energy intake but reduced hepatosplenomegaly(liver:P=0.0282,spleen:P<0.0001)and circulating inflammatory factor levels(tumor necrosis factor alpha(TNFα):22.9%,interleukin 6(IL6):30.4%,interleukin 1 beta(IL1β):33.6%,compared to LLC+CD)in cachectic mice.The HFD attenuated the loss of muscle mass(P=0.0115),functional decline,reduction in myofiber cross-sectional area,and the expression of atrophy-related genes.It also mitigated weight loss(inguinal white adipose tissue(iWAT)mass loss:54%in CD vs.12%in HFD;epididymal white adipose tissue(eWAT)mass loss:49%in CD vs.19%in HFD)and adipocyte atrophy in both iWAT and eWAT,concurrently reducing adipose browning and inflammatory factor expression.Mechanistically,transcriptome analysis of muscle and iWAT implicated adiponectin-related pathways.The HFD enhanced adiponectin expression in iWAT,partially restored circulating adiponectin levels(9.6%,P=0.0220,compared to LLC+CD),and upregulated AdipoR1 expression in muscle.This increased adiponectin expression in adipose tissue appeared to be mediated by peroxisome proliferator-activated receptor gamma(PPARγ)and CCAAT/enhancer-binding protein alpha(C/EBPα).Consequently,gene expression associated with mitochondrial biogenesis,muscle cell regeneration,and fatty acid utilization was activated in muscle tissue.An HFD mitigates fat loss and muscle atrophy in cancer cachexia.It restores adiponectin secretion in adipose tissue and attenuates systemic inflammation.These findings underscore the therapeutic potential of dietary modulation in cachexia and highlight the fat-to-muscle axis as a promising target for future interventions. 展开更多
关键词 Cachexia High-fat diet Adipose wasting Muscle atrophy Adiponectin
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High-lipid diets exacerbate copper-induced hepatointestinal toxicity in yellow catfish(Pelteobagrus fulvidraco)via gut microbiota dysbiosis 认领 引用
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作者 Lei Wang Heng Wang +2 位作者 Xuan Xue Chang Gao Yunzhi Yan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期729-740,共12页
Copper(Cu)-contained chemicals and high-lipid diets are commonly applied in aquaculture, both of them are capable of negatively affecting fish health via complicated mechanisms, yet their microbiota-mediated interacti... Copper(Cu)-contained chemicals and high-lipid diets are commonly applied in aquaculture, both of them are capable of negatively affecting fish health via complicated mechanisms, yet their microbiota-mediated interactions remain unclear. This study investigated their combined effects on yellow catfish(Pelteobagrus fulvidraco). A control(Con), high-lipid(HL), and HL + antibiotics(HLA, deplete intestinal microbiota) diets were fed fish for nine weeks, and half fish underwent acute Cu exposure(0.8 mg/L) during week nine(assigned as ConCu, HLCu,and HLACu, respectively). Results showed the HL feeding impaired growth but not Cu exposure. The HL and HLA groups showed exacerbated hepatic vacuolization, oxidative stress(reduced antioxidant enzymes, elevated malondialdehyde(MDA), and inflammation(upregulated tnfα, il1β, and nfκb expression). Cu exposure worsened these effects in all groups, further reducing intestinal villus length and tight junction genes(zo1 and occludin)expression while activating mitogen-activated protein kinase(MAPK)-related inflammation. Hepatic Cu accumulation followed HLACu > HLCu > ConCu(P < 0.05), linked to upregulated Cu transporters(ctr1 and ctr2) and metallothionein(mt2) expression. Microbiota analysis revealed high-lipid diet and Cu exposure caused microbiota dysbiosis, reducing Plesiomonas and Pseudomonas abundances, which amplified copper toxicity. This study demonstrates that high-lipid diets intensify Cu-induced hepatointestinal toxicity via oxidative and inflammatory pathways and microbiota dysbiosis, highlighting microbiome-driven Cu metabolism as a key mechanism in fish toxicity. 展开更多
关键词 High lipid diet Copper exposure Liver damage Intestinal microbiota
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Encapsulation of Antarctic krill oil in alginate-gelatin hydrogel alleviates hyperlipidemia in high-fat-diet fed rats 认领 引用
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作者 Xuan Ma Yiming Wei +6 位作者 Yi He Chenrui Zhao Qin Chen Bo Liu Tao Wei Wenjie Yan Feng Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期253-262,共10页
Krill oil is effective in reducing blood lipid levels,particularly in individuals with severe hyperlipidemia.However,poor water insolubility and stability limited its usage.This study investigated a method for encapsu... Krill oil is effective in reducing blood lipid levels,particularly in individuals with severe hyperlipidemia.However,poor water insolubility and stability limited its usage.This study investigated a method for encapsulating Antarctic krill oil using alginate(ALG)and gelatin(GLN)to enhance its stability and bioactivity.The encapsulation efficiency,functional group integrity,swelling rate,and lipid-lowering activity were assessed.Results indicated that the optimal encapsulation conditions were identified with an ALG:GLN ratio of 2:1(m/m),coagulation bath of 9%CaCl2,and a nozzle size of 750μm,resulting in 69.34%encapsulation efficiency.Fourier-transform infrared spectroscopy confirmed successful encapsulation.The ALG-GLN shell materials enriched astaxanthin in krill oil and protected it from harsh gastric conditions,enabling targeted intestinal release.In a high-fat diet-induced rat model,krill oil microcapsules significantly reduced triglycerides(TG),total cholesterol(TC),and low-density lipoprotein-cholesterol(LDL-C)levels while increasing high-density lipoprotein-cholesterol(HDL-C)levels compared to unencapsulated krill oil.Additionally,the microcapsules elevated nitric oxide(NO)levels,enhanced superoxide dismutase(SOD)activity,and reduced malondialdehyde(MDA)levels,liver and perirenal fat weight.Therefore,encapsulating Antarctic krill oil in alginate-gelatin hydrogel offers a promising strategy for managing hyperlipidemia and associated metabolic disorders. 展开更多
关键词 Krill oil Microcapsule Alginate,gelatin High-fat diet
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The updated requirements and functional roles of dietary protein and amino acids in ducks:a comprehensive review 认领 引用
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作者 Yongbao Wu Yong Jiang +2 位作者 Jing Tang Shuisheng Hou Zhiguo Wen 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第4期1771-1790,共20页
Waterfowl,primarily ducks,constitute a major commercial poultry species globally,their production efficiency is heavily influenced by dietary protein and amino acid intake.Although the National Research Council(NRC,Nu... Waterfowl,primarily ducks,constitute a major commercial poultry species globally,their production efficiency is heavily influenced by dietary protein and amino acid intake.Although the National Research Council(NRC,Nutrient requirements of poultry,1994)established fundamental recommendations for protein and amino acid requirements in ducks,tremendous improvements and changes(growth speed,rearing system,and dietary strategy)have been made in duck industry over the past decades.Consequently,these standards no longer adequately reflect the nutritional needs of modern duck production systems.This review presents updated estimates of dietary crude protein and key amino acid requirements,including methionine,lysine,threonine,tryptophan,and arginine,etc.,which are essential for formulating precision diets to maximize growth performance,carcass yield in meat ducks,as well as reproductive performance in laying ducks and breeders.Furthermore,the functional roles of these amino acids as critical regulators of physiological processes are systematically examined,including lipid metabolism(methionine and threonine),intestinal barrier integrity(threonine),regulation of feed intake via nitric oxide(arginine),and the modulation of behavior and stress responses(tryptophan).The implementation of low-protein dietary strategies(crude protein levels as low as 15%for growing meat ducks,and 14.5%for laying ducks)is also discussed for maintaining performance while improving nitrogen utilization efficiency.The recent publication of updated Chinese national feeding standards for meat-type(GB/T 45103-2024)and laying ducks(GB/T 41189-2021)incorporates these modern research advances,representing a significant milestone and providing a modern framework to guide the global duck industries.In summary,this review highlights the urgent need to move beyond outdated nutritional standards and adopt modern,evidence-based amino acid requirements tailored to modern duck production.The integration of low-protein diet strategies along with a refined understanding of amino acid functions is crucial for optimizing duck production,enhancing nutrient efficiency,and reducing environmental impacts.Future research should focus on establishing the precise requirements for other essential amino acids and certain non-essential amino acids,and further elucidating how amino acids molecularly modulate gene expression,signaling pathways,and gut microbiota to develop innovative and sustainable nutritional strategies for ducks. 展开更多
关键词 Amino acid requirement Duck nutrition Functional role Growth performance Low-protein diet Precision feeding
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Metabarcoding of gut content reveals the trophic interactions and dietary breadth of an artificially released generalist predator in agricultural landscapes 认领 引用
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作者 Weidong Huang Pingzhou Zhu +7 位作者 Zening Wang Zihua Zhao Chunyan Yang Yuange Duan Jinhong Zhou Hu Li Zhenyuan Xia Wanzhi Cai 《Ecological Frontiers》 CSCD 2026年第1期317-324,共8页
A limited understanding of the feeding habits of ecosystem service providers is a notable obstacle to the deployment of natural enemies in pest management.Understanding the dietary diversity of predators can enhance c... A limited understanding of the feeding habits of ecosystem service providers is a notable obstacle to the deployment of natural enemies in pest management.Understanding the dietary diversity of predators can enhance conservation strategies and assess their effects on pest populations.In this study,we used metabarcoding of DNA extracted from the gut contents of an artificially released generalist predator,Eocanthecona furcellata,collected from tobacco cultivation fields in Yunnan Province,China.We aimed to investigate prey composition,selectivity,and efficiency of biological control.Among the individuals of E.furcellata,we detected diverse potential prey,comprising 53 insect species across 28 families and seven orders.Several agricultural pests,including Spodoptera exigua,S.litura,Helicoverpa armigera,and Agrotis segetum,were identified.Diptera are important in the diet of E.furcellata,with 22 species from 14 families accounting for 52.2%of the observed predation events.Eocanthecona furcellata consumed certain beneficial predators present in the tobacco fields,such as carabid beetles,hoverflies,wasps,and lacewings,although the incidence was generally low,except for Syrphidae.Our findings revealed previously unidentified trophic linkages involving E.furcellata with pest species and other biological control agents,as well as highlighting the critical role of neutral insects in shaping the dietary spectrum of E.furcellata in tobacco fields.This study establishes an important foundation for integrating metabarcoding technology into biological control research,particularly for elucidating trophic interactions between natural insect enemies and their prey. 展开更多
关键词 DNA metabarcoding Trophic interaction Biological control Agroecosystems Diet
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Dietary drivers of gut microbiota diversity and function in wildlife of Wolong Nature Reserve:a metagenomic study 认领 引用
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作者 Feiyun Huang Xiaogang Shi +7 位作者 Peng Chen Qiang Hu Yongqi Zhao Zhoulong Chen Wen Ma Qihao Tan Xi Feng Xiuyue Zhang 《Current Zoology》 SCIE CAS CSCD 2026年第1期14-29,共16页
While diet is known to regulate the composition,function,and diversity of the human gut microbiome,its effects on wildlife remain understudied.Here,noninvasive sampling methods were first used to conduct metagenomic a... While diet is known to regulate the composition,function,and diversity of the human gut microbiome,its effects on wildlife remain understudied.Here,noninvasive sampling methods were first used to conduct metagenomic analyses of the gut microbiomes of 10 protected wild animals in the Wolong Nature Reserve.There were significant differences in microbiota composition and function between herbivores and carnivores.Herbivores exhibited higher microbial diversity and evenness(Shannon and Pielou indices),with Bacillota and Acinetobacter predominating,whereas carnivores were enriched in Pseudomonadota and Escherichia.Cellulose-degrading bacterium Ruminococcus champanellensis was abundant in herbivores,while Rhodococcus and Pediococcus,which were associated with toxin degradation and pathogen inhibition,were more prevalent in carnivores.Carnivores showed higher lipid metabolism and protein degradation,as evidenced by the enrichment of leucyl aminopeptidase and oligopeptidase B,while herbivores demonstrated superior cellulose and starch digestion,characterized by the enrichment of cellulose 1,4-beta-cellobiosidase.Stochastic processes shaped gut microbiome assembly,especially in herbivores.Potential health risks from pathogens such as Escherichia and Listeria were identified,and Escherichia abundance was positively correlated with niche width.Furthermore,the findings suggest that high-altitude environments may promote the persistence and spread of pathogens.Overall,our findings underscore the intricate linkages between diet,gut microbiota composition,assembly processes,and host ecology in protected wildlife,address a key knowledge gap,and provide important theoretical and practical insights for ecological conservation,species restoration,and environmental management. 展开更多
关键词 diet and wildlife gut microbiota opportunistic pathogens stochastic processes Wolong Nature Reserve
An ultra-processed food-based cafeteria diet induces obesity,metabolic dysfunction,and tissue-specific gene dysregulation in C57BL/6 mice 认领 引用
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作者 Guilherme Coutinho Kullmann Duarte Daisy Crispim +7 位作者 Shiva Cerutti Wittée Joana Raquel Nunes Lemos Natalia Emerim Lemos Mayara Souza de Oliveira Melissa Daniele Alves Eloísa Toscan Massignam Tais Silveira Assmann Felipe Mateus Pellenz 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第3期429-441,共13页
Background:The cafeteria diet(CAFD)model has been used to mimic the Western-style“junk food”eating pattern,inducing obesity in rodents.As the dietary composition varies across studies,we developed a CAFD model based... Background:The cafeteria diet(CAFD)model has been used to mimic the Western-style“junk food”eating pattern,inducing obesity in rodents.As the dietary composition varies across studies,we developed a CAFD model based on commonly consumed Brazilian ultra-processed foods to evaluate its effect on weight gain,metabolic parameters,and gene expression in C57BL/6 mice.Methods:Forty male C57BL/6 mice were assigned to either a standard diet(SD)group or a CAFD group for 16 weeks.Biometric data,glycemic control,insulin resistance(IR),hepatic steatosis,and serum leptin and adiponectin levels were assessed.Expressions of 27 genes involved in adipocytokine signaling,inflammation,apoptosis,lipid,and glucose metabolism were analyzed using quantitative real-time polymerase chain reaction in visceral(VAT)and subcutaneous(SAT)adipose tissues,liver,and skeletal muscle.Results:CAFD-fed mice exhibited significantly greater weight gain,hyperglycemia,elevated IR,and hepatic steatosis compared to SD controls.Circulating leptin and adiponectin levels increased in the CAFD group.Gene expression analysis revealed significant dysregulation in VAT(19 genes),SAT(6 genes),liver(11 genes),and muscle(4 genes)of the CAFD group,affecting pathways related to adipocytokine signaling,oxidative stress,inflammation,apoptosis,and lipid and glucose metabolism.Additionally,an increased Itgax-to-Llgl1 ratio in VAT of the CAFD mice indicated a phenotypic shift in macrophages from M2 to pro-inflammatory M1.Conclusion:This CAFD model efficiently induces obesity,metabolic dysfunction,and tissue-specific alterations in gene expression in C57BL/6 mice,supporting its use as a relevant model for studying the molecular and inflammatory mechanisms underlying diet-induced obesity. 展开更多
关键词 C57BL6 mice cafeteria diet hepatic steatosis insulin resistance obesity
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Aberrant histone acetylation and dysregulated synaptic plasticity in cognitive impairment induced by a highmethionine diet 认领 引用
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作者 Jianting Li Yuan Fu +10 位作者 Xiaolong Gu Qi Xie Zengli Liu Zhihua Cao Lu Li Jiaxin Ren Yang Li Hailan Yang Zhiwei Peng Zhizhen Liu Jun Xie 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3842-3853,共12页
Cognitive impairment is a complex neurodegenerative disorder,and increased homocysteine levels are recognized as a major risk factor for this condition.Epigenetic modifications,particularly histone acetylation,have be... Cognitive impairment is a complex neurodegenerative disorder,and increased homocysteine levels are recognized as a major risk factor for this condition.Epigenetic modifications,particularly histone acetylation,have been implicated in the progression of cognitive impairment;however,the mechanisms underlying hyperhomocysteinemia-induced cognitive impairment remain unclear.In this study,we developed an hyperhomocysteinemia-induced cognitive impairment model by feeding mice a high-methionine diet and conducted behavioral and molecular analyses to elucidate the mechanisms involved in cognitive impairment.Behavioral experiments revealed significant cognitive deficits and neuroinflammation accompanied by a marked decrease in histone H3 lysine 27 acetylation in the hippocampus and cortex.Furthermore,metabolomic profiling and chromatin immunoprecipitation sequencing demonstrated substantial shifts in the levels of homocysteine metabolites and identified histone H3 lysine 27 acetylation-targeted genes involved in synaptic long-term potentiation,including Gria1,Gria3,Grin2a,Grin2b,Slc1a1,Slc24a2,Ptk2b,and Src.RNA sequencing confirmed that hyperhomocysteinemia induced neurodegeneration.In vitro experiments confirmed that decreased histone H3 lysine 27 acetylation downregulates the expression of these target genes in homocysteine-treated HT-22 cells,thereby impairing synaptic plasticity.Collectively,these findings suggest that aberrant expression of long-term potentiation-related genes regulated by histone H3 lysine 27 acetylation is a key driver of hyperhomocysteinemia-induced cognitive impairment.Targeting histone H3 lysine 27 acetylation-mediated epigenetic dysregulation may be a promising therapeutic strategy,offering potential avenues for intervention in individuals with cognitive impairment and neurodegenerative disorders. 展开更多
关键词 cognitive impairment high-methionine diets histone H3 lysine 27 acetylation homocysteine nerve regeneration synaptic long-term potentiation
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Dietary restriction during active cancer therapy is associated with improved treatment response:a systematic review and meta-analysis 认领 引用
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作者 Kajal Agrawal Dominic Shao Yong Goh +8 位作者 Ee Chern Ng Shyn Yi Tan Carlos Cifuentes-González Jason Xing Kang William K.K.Wu Rashid N.S.Lui Rupesh Agrawal Yusuf Ali Sunny H.Wong 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第8期1193-1197,I0020-I0022,共5页
Cancer remains a leading cause of death worldwide,despite advances in surgery,chemotherapy,radiotherapy,and immunotherapy1.Challenges,like treatment-related toxicities and resistance,limit the overall benefits of curr... Cancer remains a leading cause of death worldwide,despite advances in surgery,chemotherapy,radiotherapy,and immunotherapy1.Challenges,like treatment-related toxicities and resistance,limit the overall benefits of current cancer therapies,leading to increased interest in supportive strategies that can boost treatment effectiveness while maintaining tolerability.Dietary restrictions,including calorie restriction(CR),a fasting-mimicking diet(FMD),and short-term fasting(STF),are emerging as promising adjuncts in cancer treatment by modulating tumour metabolism and the body’s stress-response pathways2.CR is defined as a sustained reduction in daily caloric intake(typically 20%–40%).A FMD is defined as a low-calorie,low-protein,low-carbohydrate dietary regimen administered over 3–5 d per cycle.STF is defined as complete or near-complete fasting lasting 24–72 h surrounding therapy.Cancer cells undergo significant metabolic reprogramming,primarily relying on aerobic glycolysis and growth factor signalling,a phenomenon known as the Warburg effect.This dependency makes malignant cells highly vulnerable to disruptions in the nutrient supply. 展开更多
关键词 fasting mimicking diet treatment response short term fasting calorie restriction cr supportive strategies calorie restriction cancer therapy dietary restriction
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Dietary inflammatory potential and glaucoma susceptibility:a nationally representative study from NHANES 认领 引用
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作者 Hui-Min Shan Yong Tao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第5期966-973,共8页
AIM:To evaluate the association between proinflammatory dietary patterns,as quantified by the dietary inflammator y index(DII),and the prevalence of glaucoma.METHODS:This population-based study used data from the Nati... AIM:To evaluate the association between proinflammatory dietary patterns,as quantified by the dietary inflammator y index(DII),and the prevalence of glaucoma.METHODS:This population-based study used data from the National Health and Nutrition Examination Survey(2005-2008).DII scores were calculated based on nutrient data derived from dietary questionnaires.The association between DII scores and glaucoma risk was assessed using sample-weighted,covariate-adjusted multivariable logistic regression models,with further stratified analyses performed across subgroups.RESULTS:A total of 5659 eligible participants aged 40-85y were included,of whom 383(6.7%)had glaucoma and 5276(93.3%)did not.After adjustment for covariates,participants in the highest DII tertile had a 1.35-fold increased risk of glaucoma[odds ratio(OR)=1.35,95%confidence interval(CI):1.03-1.79],with a significant linear trend(P for trend=0.034).Restricted cubic spline analysis further verified the association between DII scores and glaucoma risk(P=0.043).In subgroup analyses,a significant positive association between higher DII scores and elevated glaucoma risk was observed in males(OR for tertile 3 vs 1=1.48,95%CI:1.02-2.15;P for trend=0.049),participants with diabetes(OR=1.56,95%CI:1.04-2.34;P for trend=0.028),and participants with obesity(OR=1.66,95%CI:1.07-2.58;P for trend=0.023).CONCLUSION:A pro-inflammatory diet,reflected by higher DII scores,is positively associated with an increased risk of glaucoma among U.S.adults.These findings suggest that anti-inflammatory dietary interventions may serve as a potential preventive strategy against glaucoma. 展开更多
关键词 glaucoma chronic inflammation diet dietary inflammatory index National Health and Nutrition Examination Survey
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Dietary and nutritional correlates of gastroesophageal reflux disease symptoms:A comprehensive island-wide study in Sri Lanka 认领 引用
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作者 Nilanka Wickramasinghe Ahthavann Thuraisingham +4 位作者 Achini Jayalath Dharmabandu Nandadeva Samarasekera Etsuro Yazaki Ranil Jayawardena Niranga Manjuri Devanarayana 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第3期222-233,共12页
BACKGROUND Diet is widely recognized as a significant contributor to the development and exacerbation of gastroesophageal reflux disease(GERD)symptoms.However,evidence on the impact of specific dietary factors remains... BACKGROUND Diet is widely recognized as a significant contributor to the development and exacerbation of gastroesophageal reflux disease(GERD)symptoms.However,evidence on the impact of specific dietary factors remains inconsistent.AIM To identify the dietary and nutritional correlates of GERD symptoms in Sri Lankan adults.METHODS A cross-sectional analytic study was conducted on 1200 adults aged 18-70 years,recruited through stratified random cluster sampling across all 25 districts of Sri Lanka.Data was collected using interviewer-administered,country-validated tools:A GERD symptom screening tool and a food frequency questionnaire.Anthropometric measures(weight,height,abdominal and hip circumferences)were obtained using calibrated and sensitive instruments.Subjects having heartburn and/or regurgitation at least once per week were diagnosed to have GERD.They were compared with those without GERD(controls).RESULTS In our population(n=1200,mean±SD age:42.7±14.4 years,46.1%males),significant dietary triggers of GERD symptoms included oily foods,bread,wheat,coffee,and sour or vinegar-based foods(P0.05).Total daily fat and fiber intake showed no correlation with GERD symptoms;however,bloating was associated with higher fat and fiber intake,greater fruit and vegetable consumption,and higher body mass index.These findings highlight dietary patterns and habits distinctive to the Sri Lankan population,where frequent consumption of oily and wheat-based foods may contribute to GERD symptom prevalence.CONCLUSION Some dietary items,such as oily foods,wheat,coffee,and sour/vinegar foods,and diet-related habits,such as fat intake,skipping breakfast,and lying down after meals,have a significant association with GERD symptoms as previously reported around the world.Bread is significantly associated with GERD symptoms in Sri Lankan adults,which has not been reported previously.Contrary to common belief,there was no significant association between GERD and nutrient intake or obesity.In addition,not only participants fulfilling criteria for GERD,but even controls were affected by food items triggering heartburn.Thus,lifestyle modifications based on diet and dietary habits are integral to managing GERD symptoms. 展开更多
关键词 Diet Dietary habits Gastroesophageal reflux disease Nutrition Heartburn
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Protective effects of kaempferol against diet-induced metabolic disorders 认领 引用
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作者 Vinesh Sharma Vikram Patial 《World Journal of Hepatology》 2026年第6期29-36,共8页
The study examines the effects of kaempferol on obesity and steatotic liver disease in C57BL/6J mice using an Indian diet-mimicking experimental animal model.Obesity and metabolic dysfunction-associated steatotic live... The study examines the effects of kaempferol on obesity and steatotic liver disease in C57BL/6J mice using an Indian diet-mimicking experimental animal model.Obesity and metabolic dysfunction-associated steatotic liver disease prevalence is rising in India due to high-calorie dietary habits.The condition starts with simple hepatic fat accumulation and may progress to fibrosis and cirrhosis.An Indian high-fat diet significantly induced the macrovesicular as well as microvesicular steatosis in mice with increased serum transforming growth factor beta level.Kaempferol,a natural flavonoid,is generally known for its lipid-lowering potential.In this study,kaempferol treatment for four weeks reduced body weight,steatosis,and hepatic inflammation induced by the Indian high-fat diet.Moreover,kaempferol stabilized the liver injury markers and reduced the triglyceride levels.In conclusion,the study demonstrated the potential of kaempferol as a therapeutic agent for managing metabolic dysfunction-associated steatotic liver disease associated with high-calorie region-specific dietary patterns. 展开更多
关键词 Fibrosis Indian high-fat diet Kaempferol Liver Metabolic-dysfunctionassociated steatotic liver disease Transforming growth factor beta
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