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Mesolimbic Dopaminergic Encoding of Decision Value:Linking Phenotype-Specific Signals to Strategic Adaptation 认领 引用 被引量：1
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作者 Zhengyi Xu Dadao An +2 位作者 Jingjia Liang Lingyan Zheng Zhong Chen 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第4期937-940,共4页
Numerous neuropsychiatric disorders are characterized by significant impairments in decision-making function.These include impulsive decision-making in attention-deficit hyperactivity disorder(ADHD)[1],excessive risk-... Numerous neuropsychiatric disorders are characterized by significant impairments in decision-making function.These include impulsive decision-making in attention-deficit hyperactivity disorder(ADHD)[1],excessive risk-taking during manic episodes in bipolar disorder,and the distorted prioritization observed in substance use disorders.Decisionmaking involves reflecting on the outcomes of past actions and weighing the potential consequences of future actions.In this complex balancing process,mesolimbic dopamine influences reward value assessment,the strength of motivation,and the initiation of action[2]. 展开更多
关键词 phenotype specific signals bipolar disorderand strategic adaptation decision making reflecting outcomes past actions mesolimbic dopaminergic encoding distorted prioritization balancing processmesolimbic dopamine
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Emerging role of microglia in the developing dopaminergic system:Perturbation by early life stress 认领 引用 被引量：2
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作者 Kaijie She Naijun Yuan +4 位作者 Minyi Huang Wenjun Zhu Manshi Tang Qingyu Ma Jiaxu Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期126-140,共15页
Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily... Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily involving abnormal development and damage of the dopaminergic system,pose significant public health challenges.Microglia,as the primary immune cells in the brain,are crucial in regulating neuronal circuit development and survival.From the embryonic stage to adulthood,microglia exhibit stage-specific gene expression profiles,transcriptome characteristics,and functional phenotypes,enhancing the susceptibility to early life stress.However,the role of microglia in mediating dopaminergic system disorders under early life stress conditions remains poorly understood.This review presents an up-to-date overview of preclinical studies elucidating the impact of early life stress on microglia,leading to dopaminergic system disorders,along with the underlying mechanisms and therapeutic potential for neurodegenerative and neurodevelopmental conditions.Impaired microglial activity damages dopaminergic neurons by diminishing neurotrophic support(e.g.,insulin-like growth factor-1)and hinders dopaminergic axon growth through defective phagocytosis and synaptic pruning.Furthermore,blunted microglial immunoreactivity suppresses striatal dopaminergic circuit development and reduces neuronal transmission.Furthermore,inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons,inhibiting dopamine synthesis,reuptake,and receptor activity.Enhanced microglial phagocytosis inhibits dopamine axon extension.These long-lasting effects of microglial perturbations may be driven by early life stress–induced epigenetic reprogramming of microglia.Indirectly,early life stress may influence microglial function through various pathways,such as astrocytic activation,the hypothalamic–pituitary–adrenal axis,the gut–brain axis,and maternal immune signaling.Finally,various therapeutic strategies and molecular mechanisms for targeting microglia to restore the dopaminergic system were summarized and discussed.These strategies include classical antidepressants and antipsychotics,antibiotics and anti-inflammatory agents,and herbal-derived medicine.Further investigations combining pharmacological interventions and genetic strategies are essential to elucidate the causal role of microglial phenotypic and functional perturbations in the dopaminergic system disrupted by early life stress. 展开更多
关键词 Chinese herbal drugs dopamine early life stress epigenetics gut-brain axis hypothalamo–pituitary–adrenal axis innate immune memory microglia neuroinflammation Parkinson disease phagocytosis reward
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Nigrostriatal dopaminergic vulnerability in Parkinson’s disease:Neuroprotective strategies 认领 引用
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作者 Estefanía Santana-Román Luis O.Soto-Rojas +1 位作者 Elias Manjarrez Oscar Arias-Carrión 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3378-3386,共9页
The selective vulnerability of nigrostriatal dopaminergic neurons is a hallmark of Parkinson’s disease and underlies its progressive motor decline.These neurons are uniquely susceptible to degeneration due to their e... The selective vulnerability of nigrostriatal dopaminergic neurons is a hallmark of Parkinson’s disease and underlies its progressive motor decline.These neurons are uniquely susceptible to degeneration due to their extensive axonal arborization,high energy demands,sustained pacemaking activity,and cytosolic dopamine metabolism,which collectively promote oxidative stress and mitochondrial dysfunction.Advances in single-nucleus RNA sequencing and spatial transcriptomics have revealed transcriptionally distinct dopaminergic subtypes within the human substantia nigra pars compacta,such as AGTR1+/SOX6+and RIT2+populations,which exhibit subtype-specific transcriptional stress signatures and are preferentially lost in Parkinson’s disease.These findings underscore the role of intrinsic vulnerability,influenced by genetic risk loci,mitochondrial stress,and protein misfolding pathways,includingα-synuclein aggregation.Furthermore,neuroinflammation,iron accumulation,and vascular dysfunction act synergistically to amplify neuronal loss.This review integrates molecular,cellular,and systems-level mechanisms contributing to dopaminergic degeneration and evaluates emerging neuroprotective strategies.These include anti-oxidative,anti-inflammatory,mitochondrial therapies,novel biomarkers,gene editing,and cell replacement techniques.Understanding the selective vulnerability of nigrostriatal subtypes offers a promising path toward precision-targeted,disease-modifying treatments for Parkinson’s disease. 展开更多
关键词 dopamine metabolism dopaminergic neurons iron accumulation neurodegeneration neurovascular factors nigrostriatal pathway oxidative stress Parkinson’s disease plasticity α-synuclein
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Cerebral dopamine neurotrophic factor for spinal cord injury:Targeting JNK1 to relieve neuroinflammation and improve neural repair 认领 引用
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作者 Yanxiao Xiang Pengchao Du +5 位作者 Yayun Zhang Hao Li Songgang Wang Xianlei Gao Xin Pan Hua Zhao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3114-3121,共8页
Previous studies have shown that endoplasmic reticulum stress induces neuronal apoptosis,necrosis,and pro-inflammatory microenvironment after spinal cord injury.The JNK pathway is activated by endoplasmic reticulum st... Previous studies have shown that endoplasmic reticulum stress induces neuronal apoptosis,necrosis,and pro-inflammatory microenvironment after spinal cord injury.The JNK pathway is activated by endoplasmic reticulum stress and reactive oxygen species.Our previous research demonstrated that cerebral dopamine neurotrophic factor has anti-inflammatory effects and promotes the repair of the damaged spinal cord after injury.However,the molecular mechanism remains unclear.In this study,we found that cerebral dopamine neurotrophic factor binds JNK1 and regulates JNK1/2-c-Jun-p53 signaling in lipopolysaccharide-induced microglia.Cerebral dopamine neurotrophic factor also alleviated neuroinflammation by reducing the secretion of pro-inflammatory cytokines.Overexpression of cerebral dopamine neurotrophic factor in a mouse model of spinal cord injury promoted nerve regeneration and motor function recovery.These findings indicate the possibility for cerebral dopamine neurotrophic factor treating spinal cord injury by targeting the JNK1/2-c-Jun-p53 pathway. 展开更多
关键词 cerebral dopamine neurotrophic factor ER stress JNK1 microenvironment microglia nerve repair neural regeneration neuroinflammation proinflammatory cytokine spinal cord injury
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Temporal Features of Gamma Activity of Hyper-direct Pathway Regulated by Dopamine Receptors in the Dyskinetic Rat 认领 引用
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作者 Pengfei Wang Weina Dai +6 位作者 Hongmin Li Weijie Li Yang Wang Yichang Liu Le Wang Fanglei Ye Yuming Xu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期107-126,共20页
Cortico-thalamic projections(the hyper-direct pathway)are implicated in levodopa-induced dyskinesia(LID),a challenging complication in the advanced stages of Parkinson’s disease(PD).Excessive beta and gamma activity ... Cortico-thalamic projections(the hyper-direct pathway)are implicated in levodopa-induced dyskinesia(LID),a challenging complication in the advanced stages of Parkinson’s disease(PD).Excessive beta and gamma activity in PD and LID has frequently been reported in recent cross-sectional studies.We aimed to investigate the temporal features of beta and gamma activity in the hyper-direct pathway during the development of PD and LID in rats,as well as the regulatory role of the dopamine receptors DI(D1Rs)and DIII(D3Rs)in these disorders.We recorded motor behavior and electrophysiological data during the development of PD and LID,and after interventions with D1R and D3R antagonists and agonists.We demonstrated exaggerated beta-band activity in the PD state and excessive gamma-band activity during on-state dyskinesia.Subsequently,process-dependent increased beta activity correlated with bradykinesia during PD modeling,while process-dependent increased gamma activity correlated with dyskinesia under the cumulative effects of levodopa during on-state dyskinesia.Finally,both D1Rs and D3Rs were found to be involved in regulating dyskinesia and gamma activity.Dynamic oscillations are closely associated with motor behavior,and mapping dynamic oscillations may be associated with optimizing deep brain stimulation parameters and developing personalized neurotherapeutic targeting.Moreover,D1Rs and D3Rs may ameliorate dyskinesia by mediating gamma oscillations. 展开更多
关键词 Parkinson’s disease Levodopa-induced dyskinesia Subthalamic nucleus Gamma oscillations Dopamine receptors
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Targeting the dopaminergic midbrain in Alzheimer's disease:Therapeutic potential of focusing on specific neural circuits rather than single molecular pathways 认领 引用
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作者 Emanuele Claudio Latagliata Stefano Puglisi-Allegra Marcello D'Amelio 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4251-4252,共2页
Alzheimer's disease(AD) remains one of the most unyielding challenges in neurology.Its complexity and heterogeneity underscore a critical need to explo re additional mechanisms that can be targeted in the early st... Alzheimer's disease(AD) remains one of the most unyielding challenges in neurology.Its complexity and heterogeneity underscore a critical need to explo re additional mechanisms that can be targeted in the early stages of the disease to prevent the worsening of functional decline.Converging basic-science and emerging clinical evidence now implicates progressive degeneration of the mesocorticolimbic dopamine(DA) system,particularly neurons in the ventral tegmental area(VTA),as a newly recognized event that predicts the onset of memory loss and occurs well before amyloid-β(Aβ) plaque deposition(Sala et al.,2021),as demonstrated in the Tg2576 mouse model of AD(Nobili et al.,2017;Cordella et al.,2018;La Barbera et al.,2022;Spoleti et al.,2024). 展开更多
关键词 tg mouse model progressive degeneration ventral tegmental area amyloid plaque deposition memory loss alzheimers disease ad mesocorticolimbic dopamine system neurology
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Human stem cell-based cell replacement therapy for Parkinson’s disease:Enhancing the survival of postmitotic dopamine neuron grafts 认领 引用 被引量：1
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作者 Tae Wan Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期689-690,共2页
Parkinson’s disease(PD)is the second most common neurodegenerative disorder.The progressive degeneration of dopamine(DA)producing neurons in the midbrain is the pathological hallmark,which leads to debilitating motor... Parkinson’s disease(PD)is the second most common neurodegenerative disorder.The progressive degeneration of dopamine(DA)producing neurons in the midbrain is the pathological hallmark,which leads to debilitating motor symptoms,including tremors,rigidity,and bradykinesia.Drug treatments,such as levodopa,provide symptomatic relief.However,they do not halt disease progression,and their effectiveness diminishes over time(reviewed in Poewe et al.,2017). 展开更多
关键词 neuronal survival cell replacement therapy dopamine neurons human stem cells bradykinesiadrug treatmentssuch Parkinsons disease neurodegenerative disorderthe parkinson s disease pd
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Colorimetric and Photothermal Hollow Nanocomposite Based on Silver-Seeded Prussian Blue Analog for Dopamine Monitoring and Photothermal Sterilization 认领 引用
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作者 Tao Ji Ze Xu +5 位作者 Ying Wang Xingchen Lu Yuqian Zhu Qingli Huang Quanshuang Li Shibao Li 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期395-406,共12页
Multi-element Prussian blue analog(PBA)nanocomposites have attracted wide attention for their superior characteristics to single-functional nanomaterials in extensive applications of diagnosis and therapy.In this stud... Multi-element Prussian blue analog(PBA)nanocomposites have attracted wide attention for their superior characteristics to single-functional nanomaterials in extensive applications of diagnosis and therapy.In this study,a novel hollow nanocomposite was designed and fabricated by embedding S2-and Ag nanoparticles into a NiCuMnFe(PBA).The introduction S2-and Ag nanoparticles greatly enhanced the catalytic and photo thermal performance of multi-element NiCuMnFe PBA.Based on its versatility of outstanding performance,a rapid and sensitive colorimetric detection platform for dopamine(DA),with a limit of detection(LOD)of 0.567μM was constructed,and an efficient antibacterial nanoplatform was obtained with highly effective antibacterial performance(100%inhibition rate of bacteria under optimal conditions).This work provides a feasible reference for the reasonable design of multifunctional nanocomposites in biosensor and medical treatment applications. 展开更多
关键词 antibacterial catalytic dopamine nanocomposites
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Preparation of Highly Bioactive Nanolignin via Dopamine Mannich Modification and Its Synergistic Effects With Zn2+in PVA Hydrogels 认领 引用
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作者 Meiling Han Hui Hui +8 位作者 Yi Yang Yan Wang Danli Zhou Yuebin Xi Yu Jing Pingxian Feng Fan-Gong Kong Huan Wang Weijun Yang 《Rare Metals》 SCIE EI CAS CSCD 2026年第7期538-550,共13页
Lignin is a natural non-toxic polyphenolic macromolecule,which shows inherent antioxidant and broad-spectrum antibacterial activities.However,due to the low content and the high bond dissociation energy of phenolic hy... Lignin is a natural non-toxic polyphenolic macromolecule,which shows inherent antioxidant and broad-spectrum antibacterial activities.However,due to the low content and the high bond dissociation energy of phenolic hydroxyl groups(Ar-O⋅H),its antioxidant and antibacterial activities are relatively weak,which limits its application as a highly bioactive biomaterial.In this study,different contents of dopamine(DA)were grafted onto the lignin nanoparticles(LNP)via a simple Mannich reaction to prepare LNP-xDA nanomaterial.LNP-1DA has an antibacterial rate of up to 99%against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus),and the antioxidant activity is 40%higher than that of LNP.Meanwhile,both LNP and LNP-DA have excellent blood and cell compatibility,whereas the hemolysis rate was less than 1%(p0.05).In order to further investigate its potential application as the bioactive wound-dressing additive,PVA/LNP-DA/Zn hydrogels were prepared by uniformly dispersing LNP-1DA in the Polyvinyl Alcohol(PVA)aqueous solution via the freezing-thawing approach,followed by immersing into the ZnCl2 solution via an equilibrium method.The synergistic effects of LNP-1DA and Zn2+coordination endowed the hydrogels with improved mechanical properties(tensile strength up to 37.9 KPa)and antibacterial activity(antibacterial rate of 99%).This work will be of significance for the high-value utilization of lignin and the development of a novel bioactive material. 展开更多
关键词 biological activity dopamine hydrogels lignin nanoparticles Zn2+coordination effect
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Brain insulin resistance and neuropsychiatric symptoms in Alzheimer's disease:A role for dopamine signaling 认领 引用
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作者 Anastasia Kontogianni Hongbin Yang Wenqiang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1995-1996,共2页
Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central com... Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central complications.Type 2 diabetes mellitus(T2DM),the most prevalent type of diabetes,affects more than 38 million individuals in the United States(approximately 1 in 10)and is defined by chronic hyperglycemia and insulin resistance,which refers to a reduced cellular response to insulin. 展开更多
关键词 reduced cellular response insulin dopamine signaling insulin resistancewhich metabolic disorder type diabetes mellitus brain insulin resistance Alzheimers disease neuropsychiatric symptoms
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Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder:Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation 认领 引用
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作者 Takahiko Nagamine 《World Journal of Clinical Pediatrics》 2026年第3期23-33,共11页
Recent evidence highlights a significant shift in the kynurenine pathway(KP)toward a neurotoxic profile in medication-naïve children with attention-deficit/hyperactivity disorder(ADHD).This article contextualizes... Recent evidence highlights a significant shift in the kynurenine pathway(KP)toward a neurotoxic profile in medication-naïve children with attention-deficit/hyperactivity disorder(ADHD).This article contextualizes these metabolic alterations–specifically the reduction in kynurenic acid(KYNA)and the elevation of the quinolinic acid(QUIN)/KYNA ratio–as active drivers of neurodeve-lopmental pathology rather than mere biomarkers.We hypothesize that chronic KP dysregulation disrupts the“N-methyl-D-aspartate-dopamine link”,where KYNA deficiency leads to N-methyl-D-aspartate receptor disinhibition,subsequently interfering with the phasic dopaminergic signaling essential for executive function.Furthermore,the convergence of these metabolic signatures with those found in affective disorders provides a biological rationale for the high rates of depressive comorbidity in ADHD.We discuss the potential for targeting the KP,particularly through kynurenine 3-monooxygenase inhibition,to restore glutamatergic homeostasis.Crucially,we address the role of blood-brain barrier permeability in ADHD as a factor that may exacerbate the impact of peripheral kynurenine metabolites on central nervous system function. 展开更多
关键词 Kynurenine pathway Dopamine N-methyl-D-aspartate receptor Neuroinflammation Blood-brain barrier
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The dopaminergic system and Alzheimer's disease 认领 引用 被引量：5
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作者 Yuhan Zhang Yuan Liang Yixue Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第9期2495-2512,共18页
Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-b... Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition.Dopamine is a crucial catecholaminergic neurotransmitter in the human body.Dopamine-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations.Howeve r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive impairment.This review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs.The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options. 展开更多
关键词 adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment
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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism 认领 引用 被引量：4
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作者 Yujie Yang Xinyi Li +7 位作者 Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第1期93-106,共14页
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.... Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders. 展开更多
关键词 aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2
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Dopamine mediates the link between aggressive behavior and biogenic amine receptor genes in mud crab Scylla paramamosain 认领 引用 被引量：1
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作者 Yuanyuan FU Xinlian HUANG +3 位作者 Lei LIU Wei ZHAI Sixiang WANG Congying HE 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2025年第5期1654-1667,共14页
Intraspecific conflict induced by the innate aggressiveness is one of the main reasons for the extremely low survival rate in mud crab Scylla paramamosain aquaculture,which have impeded the sustainable culture of the ... Intraspecific conflict induced by the innate aggressiveness is one of the main reasons for the extremely low survival rate in mud crab Scylla paramamosain aquaculture,which have impeded the sustainable culture of the species.In this study,we first classified and quantified the aggressive behavior,and established a crab aggressive behavior model,laying the foundation for subsequent research on evaluating combat intensity.The contents of 5-hydroxytryptamine(5-HT),dopamine(DA),and cAMP in the hemolymph of the mud crabs before and after fighting were measured by high-performance liquid chromatography-mass spectrometry(HPLC-MS),and the mud crabs exhibited a significant increase of 5-HT(P<0.05),while the DA and cAMP decreased significantly(P<0.05).In addition,we applied EthoVision to examine the changes of the crab behavior after DA administration.After 0.5 h of injection,the movement speed,distance,duration of aggressive behavior,and intensity of aggression in the high concentration DA group were significantly higher than those in the saline injection group and the untreated control group(P<0.05).The results of real-time quantitative polymerase chain reaction(qRT PCR)analysis showed that the expression of DA 1 in the thoracic ganglia of the mud crabs was significantly down-regulated in the DA injection group,and the aggressive behavior was weakened.Conversely,DA1 expression was up-regulated when aggressive behavior was strengthened.Besides,there were significant differences in the expression levels of receptor expression genes including 5-HT1,5-HT2,and crustacean hyperglycemic hormone(CHH)in different tissues,indicating that the alteration of aggressive behavior of the mud crab after injection with different concentrations of DA could be regulated by changes in the expression levels of corresponding receptor genes.Our results contribute to a deeper analysis of the aggressive behavior mechanism of the mud crabs and provide a theoretical basis for reducing fighting-related mortalities in aquaculture. 展开更多
关键词 Scylla paramamosain aggressive behavior behavior model dopamine(DA) gene expression
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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease 认领 引用 被引量：1
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作者 Livia La Barbera Paraskevi Krashia Annalisa Nobili 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第5期1405-1406,共2页
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histo... Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes. 展开更多
关键词 Alzheimer alterations dopamine
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Dopaminergic neurons in the dorsal raphe nucleus may modulate social dominance in mice 认领 引用
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作者 Ying-Juan Liu Qin An +8 位作者 Bai-Lin Song Jia Tian Lu Ren Ya-Han Sun Jiao-Wen Wu Jie Zhou Zhi-Xiong He Fa-Dao Tai Lai-Fu Li 《Zoological Research》 SCIE CAS CSCD 2025年第5期996-1008,共13页
Social hierarchies are central to the organizational structure of group-living species,shaping individual physiology,behavior,and social interactions.Dopaminergic(DA)systems,particularly within the ventral tegmental a... Social hierarchies are central to the organizational structure of group-living species,shaping individual physiology,behavior,and social interactions.Dopaminergic(DA)systems,particularly within the ventral tegmental area(VTA)and dorsal raphe nucleus(DR),have been linked to motivation and competitive behaviors,yet their region-specific contributions to social dominance remain insufficiently defined.This study investigated the role of VTA and DR DA neurons in regulating social dominance in sexually naïve male C57BL/6J mice.Stable hierarchies were established using the tube test,after which both dominant and subordinate mice exhibited elevated c-Fos expression within the VTA and DR.Notably,dominant mice displayed significantly greater c-Fos activation in DR DA neurons compared to subordinates.Fiber photometry revealed that DA neurons in both regions were activated during proactive push behaviors and inhibited during passive retreats,with DR neurons showing stronger activation during dominance-related actions.Chemogenetic inhibition of DR DA neurons in dominant mice reduced their social rank,whereas activation in subordinates elevated their rank.In contrast,chemogenetic modulation of VTA DA neurons had no significant effect on social dominance.Manipulation of DA neurons in both regions produced rank-dependent changes in specific anxiety-like behavioral phenotypes.These findings highlight the distinct roles of DR and VTA DA neurons in social hierarchy regulation,identifying DR DA neurons as a critical component in the modulation of social dominance. 展开更多
关键词 Social hierarchy Dorsal raphe nucleus Ventral tegmental area Dopamine Chemogenetics
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Electroless Deposition of Cu Using Dopamine as Flexible Conductive Materials 认领 引用
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作者 Jinliang Luo Dongliang Li +3 位作者 Yang Li Miaojiao Wang Xiaomin Kang Zhitao Hu 《Journal of Polymer Materials》 SCIE CAS 2025年第1期125-140,共16页
With the rapid development of flexible wearable electronic products,their application fields and demands are increasing,posing new challenges to flexible conductive materials.This paper selected flexible polydimethyls... With the rapid development of flexible wearable electronic products,their application fields and demands are increasing,posing new challenges to flexible conductive materials.This paper selected flexible polydimethylsiloxane(PDMS)as the substrate.In order to enhance the adhesion between the substrate and the metal coating,dopamine and silanization were used to co-modify its surface.A conductive layer of metallic copper is deposited on its surface using an inexpensive,easy-to-use electroless plating technique.By optimizing the process conditions,it is found that a uniform copper layer of about 0.6μm can be formed on the surface of the substrate by electroless plating at a constant temperature of 45℃ for 30 min with a conductivity of 5556 S/cm.The relative resistance changes under different deformation conditions,and the I-V curve of the LED circuit is not very different.Therefore,this paper prepared a flexible conductor with excellent electrical conductivity,high coating adhesion,and good electrical stability under large-scale deformation. 展开更多
关键词 Flexible conductors dopamine modification silanization modification electroless plating
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Enrichment-enhanced detection strategy in the optimized monitoring system of dopamine with carbon dots-based probe 认领 引用
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作者 Xilin Bai Wei Deng +1 位作者 Jingjuan Wang Ming Zhou 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第2期428-432,共5页
The complexity of living environment system demands higher requirements for the sensitivity and selectivity of the probe.Therefore,it is of great importance to develop a universal strategy for highperformance probe op... The complexity of living environment system demands higher requirements for the sensitivity and selectivity of the probe.Therefore,it is of great importance to develop a universal strategy for highperformance probe optimization.Herein,we propose a novel“Enrichment-enhanced Detection”strategy and use carbon dots-dopamine detection system as a representative model to evaluate its feasibility.The composite probe carbon dots (CDs)-encapsulated in glycol-chitosan (GC)(i.e.,CDs@GC) was obtained by simply mixing GC and CDs through noncovalent interactions,including electrostatic interactions and hydrogen bonding.Dopamine (DA) could be detected through internal filter effect (IFE)-induced quenching of CDs.In the case of CDs@GC,noncovalent interactions (electrostatic interactions) between GC and the formed quinone (oxide of DA) could selectively extract and enrich the local concentration of DA,thus effectively improving the sensitivity and selectivity of the sensing system.The nanosensor had a low detection limit of 3.7 nmol/L,which was a 12-fold sensitivity improvement compared to the bare CDs probes with similar fluorescent profiles,proving the feasibility of the“Enrichment-enhanced Detection”strategy.Further,to examine this theory in real case,we designed a highly portable sensing platform to realize visual determination of DA.Overall,our work introduces a new strategy for accurately detecting DA and provides valuable insights for the universal design and optimization of superior nanoprobes. 展开更多
关键词 Enrichment-enhanced detection strategy Optimizing pathway Improved sensitivity Dopamine Visual detection
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Levodopa and the dopamine receptor D1-Hippo/yes-associated protein axis:A novel therapeutic avenue for liver fibrosis 认领 引用
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作者 Shan-Shan Xie Zhi-Gang Liu 《World Journal of Gastroenterology》 SCIE CAS 2025年第46期1-6,共6页
Liver fibrosis remains a major global health challenge with limited therapeutic options.In their recent study,Wang et al report that levodopa,a dopamine precursor widely used in Parkinson’s disease,significantly atte... Liver fibrosis remains a major global health challenge with limited therapeutic options.In their recent study,Wang et al report that levodopa,a dopamine precursor widely used in Parkinson’s disease,significantly attenuates carbon tetrachloride-induced liver fibrosis in rats by enhancing dopamine receptor D1 expression and activating the Hippo signaling pathway,leading to phosphorylation and inactivation of yes-associated protein 1.This discovery links Gprotein-coupled receptor signaling to Hippo pathway regulation in hepatic fibrosis.The work highlights the dopamine receptor D1-Hippo/yes-associated protein 1 axis as a promising antifibrotic mechanism and introduces levodopa as a potential repurposing candidate for chronic liver disease.With its established safety and affordability,levodopa offers a rapidly translatable strategy that warrants validation in human tissues and diverse fibrosis models.Here,we place these findings in the broader context of G-protein-coupled receptor regulation of hepatic stellate cell activation,discuss translational opportunities for levodopa in liver fibrosis,and propose future directions to validate this pathway across disease models and clinical settings. 展开更多
关键词 Levodopa Liver fibrosis Dopamine receptor D1 Hippo signaling pathway Yes-associated protein Drug repurposing Hepatic stellate cell G-protein coupled receptor
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