BACKGROUND Conventional antipsychotic treatment combined with health education shows limited efficacy in patients with schizophrenia,highlighting the need for further optimization of therapeutic strategies.AIM To eval...BACKGROUND Conventional antipsychotic treatment combined with health education shows limited efficacy in patients with schizophrenia,highlighting the need for further optimization of therapeutic strategies.AIM To evaluate the therapeutic efficacy of exercise-based rehabilitation training in patients with schizophrenia.METHODS From February 2022 to February 2025,127 patients with schizophrenia were divided into a control group(n=59)managed with routine pharmacotherapy and an intervention group(n=68)receiving additional exercise-based rehabilitation training.Outcomes were assessed before and after the intervention using the Positive and Negative Syndrome Scale,the Nurses’Observation Scale for Inpatient Evaluation(NOSIE),the Stroop Color-Word Test(SCWT),the Trail Making Test,the Brief Assessment of Cognition in Schizophrenia symbol coding test,the Inpatient Psychiatric Rehabilitation Outcome Scale,and serum brain-derived neurotrophic factor levels.RESULTS After the intervention,the intervention group demonstrated significantly greater reductions in Positive and Negative Syndrome Scale scores,NOSIE negative factor scores,Trail Making Test completion time,and Inpatient Psychiatric Rehabil itation Outcome Scale total and domain scores compared with the control group.Significant post-treatment increases were observed in NOSIE positive and total scores,SCWT word and color accuracy,Brief Assessment of Cognition in Schizophrenia performance,and serum brain-derived neurotrophic factor levels in the intervention group relative to baseline and control group values.SCWT total correct responses did not differ between groups or timepoints.CONCLUSION Exercise-based rehabilitation training significantly improves psychiatric symptoms,cognitive performance,social functioning,and biological markers in patients with schizophrenia,supporting its incorporation as an adjunctive component of standard treatment.展开更多
Background:Hepato-pancreatico-biliary(HPB)patients experience significant risk of preoperative frailty.Studies assessing preventative prehabilitation in HPB populations are limited.This systematic review and meta-anal...Background:Hepato-pancreatico-biliary(HPB)patients experience significant risk of preoperative frailty.Studies assessing preventative prehabilitation in HPB populations are limited.This systematic review and meta-analysis evaluates outcomes for HPB patients treated with exercise prehabilitation.Data sources:A comprehensive search of MEDLINE(via Ovid),Embase(Ovid),Scopus,Web of Science Core Collection,Cochrane Library(Wiley),Pro Quest Dissertations,Theses Global,and Google Scholar was conducted with review and extraction following PRISMA guidelines.Included studies evaluated more than 5 adult HPB patients undergoing≥7-day exercise prehabilitation.The primary outcome was postoperative length of stay(LOS);secondary outcomes included complications,mortality,physical performance,and quality of life.Results:We evaluated 1778 titles and abstracts and selected 6(randomized controlled trial,n=3;prospective cohort,n=1;retrospective cohort,n=2)that included 957 patients.Of those,536 patients(56.0%)underwent exercise prehabilitation and 421(44.0%)received standard care.Patients in both groups were similar with regards to important demographic factors.Prehabilitation was associated with a 5.20-day LOS reduction(P=0.03);when outliers were removed,LOS reduction decreased to 1.85 days and was non-statistically significant(P=0.34).Postoperative complications(OR=0.70;95%CI:0.39 to 1.26;P=0.23),major complications(OR=0.83;95%CI:0.60 to 1.14;P=0.24),and mortality(OR=0.67;95%CI:0.17 to 2.70;P=0.57)were similar.Prehabilitation was associated with improved strength,cardiopulmonary function,quality of life,and alleviated sarcopenia.Conclusions:Exercise prehabilitation may reduce LOS and morbidity following HPB surgery.Studies with well-defined exercise regimens are needed to optimize exercise prehabilitation outcomes.展开更多
Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been demonstrated.Our aim was to assess the impact of EBCR in³70-years-old vs.y...Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been demonstrated.Our aim was to assess the impact of EBCR in³70-years-old vs.younger post-AMI patients.Methods We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 weeks.We evaluated changes in several outcomes based on pre-and post-CRP assessments.Results Of a total of 1607 patients,333(21%)were³70-years-old.After the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(P<0.05).Older patients showed a smaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in NT-pro-BNP.In the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on age.Conclusion As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.展开更多
There is general agreement today that the communicative approach to the teaching and learning of English is the correct one and that we learn English for the purpose of communicating with other English-speakers. Howev...There is general agreement today that the communicative approach to the teaching and learning of English is the correct one and that we learn English for the purpose of communicating with other English-speakers. However, this is a comparatively recent development. This paper begins with an historical overview outlining the origins of the communicative approach in Europe and the United States and noting that they arrived at a consensus for entirely different historical reasons. In China English replaced Russian as the most important foreign language a generation ago but even then the emphasis was on receptive skills. The thorny question of authenticity is then discussed. While everyone agrees that in theory authenticity is a key consideration there is considerably less agreement on how to convert theory into practice. Finally the paper goes on to note how recent practice has abandoned the teacher-centered approach in favor of the learner-centered approach and the exercise-based approach in favor of the task-based approach, The task-based approach emphasizes integrated as opposed to individual skills acquisition. Examples of integrated tasks are given in the Appendix.展开更多
摘要BACKGROUND Conventional antipsychotic treatment combined with health education shows limited efficacy in patients with schizophrenia,highlighting the need for further optimization of therapeutic strategies.AIM To evaluate the therapeutic efficacy of exercise-based rehabilitation training in patients with schizophrenia.METHODS From February 2022 to February 2025,127 patients with schizophrenia were divided into a control group(n=59)managed with routine pharmacotherapy and an intervention group(n=68)receiving additional exercise-based rehabilitation training.Outcomes were assessed before and after the intervention using the Positive and Negative Syndrome Scale,the Nurses’Observation Scale for Inpatient Evaluation(NOSIE),the Stroop Color-Word Test(SCWT),the Trail Making Test,the Brief Assessment of Cognition in Schizophrenia symbol coding test,the Inpatient Psychiatric Rehabilitation Outcome Scale,and serum brain-derived neurotrophic factor levels.RESULTS After the intervention,the intervention group demonstrated significantly greater reductions in Positive and Negative Syndrome Scale scores,NOSIE negative factor scores,Trail Making Test completion time,and Inpatient Psychiatric Rehabil itation Outcome Scale total and domain scores compared with the control group.Significant post-treatment increases were observed in NOSIE positive and total scores,SCWT word and color accuracy,Brief Assessment of Cognition in Schizophrenia performance,and serum brain-derived neurotrophic factor levels in the intervention group relative to baseline and control group values.SCWT total correct responses did not differ between groups or timepoints.CONCLUSION Exercise-based rehabilitation training significantly improves psychiatric symptoms,cognitive performance,social functioning,and biological markers in patients with schizophrenia,supporting its incorporation as an adjunctive component of standard treatment.
摘要Background:Hepato-pancreatico-biliary(HPB)patients experience significant risk of preoperative frailty.Studies assessing preventative prehabilitation in HPB populations are limited.This systematic review and meta-analysis evaluates outcomes for HPB patients treated with exercise prehabilitation.Data sources:A comprehensive search of MEDLINE(via Ovid),Embase(Ovid),Scopus,Web of Science Core Collection,Cochrane Library(Wiley),Pro Quest Dissertations,Theses Global,and Google Scholar was conducted with review and extraction following PRISMA guidelines.Included studies evaluated more than 5 adult HPB patients undergoing≥7-day exercise prehabilitation.The primary outcome was postoperative length of stay(LOS);secondary outcomes included complications,mortality,physical performance,and quality of life.Results:We evaluated 1778 titles and abstracts and selected 6(randomized controlled trial,n=3;prospective cohort,n=1;retrospective cohort,n=2)that included 957 patients.Of those,536 patients(56.0%)underwent exercise prehabilitation and 421(44.0%)received standard care.Patients in both groups were similar with regards to important demographic factors.Prehabilitation was associated with a 5.20-day LOS reduction(P=0.03);when outliers were removed,LOS reduction decreased to 1.85 days and was non-statistically significant(P=0.34).Postoperative complications(OR=0.70;95%CI:0.39 to 1.26;P=0.23),major complications(OR=0.83;95%CI:0.60 to 1.14;P=0.24),and mortality(OR=0.67;95%CI:0.17 to 2.70;P=0.57)were similar.Prehabilitation was associated with improved strength,cardiopulmonary function,quality of life,and alleviated sarcopenia.Conclusions:Exercise prehabilitation may reduce LOS and morbidity following HPB surgery.Studies with well-defined exercise regimens are needed to optimize exercise prehabilitation outcomes.
摘要Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been demonstrated.Our aim was to assess the impact of EBCR in³70-years-old vs.younger post-AMI patients.Methods We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 weeks.We evaluated changes in several outcomes based on pre-and post-CRP assessments.Results Of a total of 1607 patients,333(21%)were³70-years-old.After the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(P<0.05).Older patients showed a smaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in NT-pro-BNP.In the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on age.Conclusion As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.
摘要There is general agreement today that the communicative approach to the teaching and learning of English is the correct one and that we learn English for the purpose of communicating with other English-speakers. However, this is a comparatively recent development. This paper begins with an historical overview outlining the origins of the communicative approach in Europe and the United States and noting that they arrived at a consensus for entirely different historical reasons. In China English replaced Russian as the most important foreign language a generation ago but even then the emphasis was on receptive skills. The thorny question of authenticity is then discussed. While everyone agrees that in theory authenticity is a key consideration there is considerably less agreement on how to convert theory into practice. Finally the paper goes on to note how recent practice has abandoned the teacher-centered approach in favor of the learner-centered approach and the exercise-based approach in favor of the task-based approach, The task-based approach emphasizes integrated as opposed to individual skills acquisition. Examples of integrated tasks are given in the Appendix.