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Experimental data-driven deep neural network modeling and prediction for the streaks of turbulent separated shear flow 认领 引用 被引量：1
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作者 Xingyu Ma Jiateng Pan +1 位作者 Yihong Liu Nan Jiang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第7期52-58,共7页
In this paper,we report a recent experimental study of streak structures in the turbulent separated shear flow by datadriven deep neural network.By applying spanwise-aligned tetrahedron vortex generators upstream of a... In this paper,we report a recent experimental study of streak structures in the turbulent separated shear flow by datadriven deep neural network.By applying spanwise-aligned tetrahedron vortex generators upstream of a plane backward-facing step,spanwise-aligned high-and low-speed streaks were generated within the separated shear layer behind the step.The velocity profiles of the shear flow were measured by single-probe hot-wire anemometer in both the streamwise-vertical and the streamwise-spanwise planes in the wind tunnel.Deep neural network models are trained and verified based on the experimental datasets.The input parameter sets include the vortex generator height,spanwise spacing,and the spatial coordinates within the measurement domain,while the output parameter sets are mean and root-mean-square velocities of the shear flow.Mean squared errors between the model-predicted and experimentally measured data are used for quality evaluation of different deep neural network model designs,among which the minimum error of the optimal design descends less than 1%.For other vortex generator parameters,which are not measured in the wind tunnel or used in the training,the model prediction provides reasonable mean velocity contours with streak structures.Thus,we find that the experimental data-driven modeling approach shows reliable robustness for nonlinear fitting of complex datasets as well as considerable generalization for turbulent coherent structures. 展开更多
关键词 Streak Experimental data-driven Deep neural network Vortex generator Backward-facing step
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Dynamic characteristics analysis of rack railway track system under traction conditions by experimental test 认领 引用 被引量：1
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作者 Zhihui Chen Guojun Yang +3 位作者 Zaigang Chen Haitao Zhang Jizhong Yang Wanming Zhai 《Railway Engineering Science》 EI 2026年第1期40-54,共15页
The dynamic characteristics of the track system can directly affect its service performance and failure process.To explore the load characteristics and dynamic response of the track system under the dynamic loads from... The dynamic characteristics of the track system can directly affect its service performance and failure process.To explore the load characteristics and dynamic response of the track system under the dynamic loads from the rack vehicle in traction conditions,a systematic test of the track subsystem was carried out on a large-slope test line.In the test,the bending stress of the rack teeth,the wheel-rail forces,and the acceleration of crucial components in the track system were measured.Subsequently,a detailed analysis was conducted on the tested signals of the rack railway track system in the time domain and the time-frequency domains.The test results indicate that the traction force significantly affects the rack tooth bending stress and the wheel-rail forces.The vibrations of the track system under the traction conditions are mainly caused by the impacts generated from the gear-rack engagement,which are then transferred to the sleepers,the rails,and the ballast beds.Furthermore,both the maximum stress on the racks and the wheel-rail forces measured on the rails remain below their allowable values.This experimental study evaluates the load characteristics and reveals the vibration characteristics of the rack railway track system under the vehicle’s ultimate load,which is very important for the load-strengthening design of the key components such as racks and the vibration and noise reduction of the track system. 展开更多
关键词 Rack railway Vehicle-track coupled dynamics Traction condition Experimental test Gear-rack engagement
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Experimental techniques for qualitative and quantitative characterization of shale oil reservoir space,minerals,and fluids 认领 引用 被引量：1
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作者 Siyu Chen Zhenkai Huang +6 位作者 Guangyou Zhu Xi Li Zhiyong Chen Ruilin Wang Yue Huang Shengnan Liu Bijun Huang 《Energy Geoscience》 EI CAS CSCD 2026年第2期1-16,共16页
Characterizing shale oil reservoirs encompassing pore space,mineralogy,and fluids is fundamental to effective exploration and development.Recent advances in experimental techniques have significantly improved both the... Characterizing shale oil reservoirs encompassing pore space,mineralogy,and fluids is fundamental to effective exploration and development.Recent advances in experimental techniques have significantly improved both the qualitative and quantitative analysis of these components;however,a comprehensive systematic review is lacking.High-resolution imaging technologies,such as Scanning Electron Microscopy(SEM),Field Emission Scanning Electron Microscopy(FE-SEM),and Focused Ion Beam Scanning Electron Microscopy(FIB-SEM),enable detailed visualization of pore structures.Gas adsorption and high-pressure mercury intrusion methods provide accurate pore-scale quantification.Moreover,techniques like X-ray Diffraction(XRD),X-ray Fluorescence Spectroscopy(XRF),and Electron Probe Microanalysis(EPMA)allow precise mineral identification and compositional analysis.Confocal Scanning Laser Microscopy(CSLM),Raman Spectroscopy,Nuclear Magnetic Resonance(NMR),and Rock Pyrolysis provide insights into fluid occurrence and content within shale reservoirs.Based on a comprehensive review of existing research,this study identifies several key future directions:(1)addressing the challenges of nanopore observation in reservoir space characterization while minimizing the impact of sample preparation on pore structure;(2)improving the accuracy of quantitative mineral analysis and developing advanced new technologies for the precise measurement of complex mineral compositions;(3)enhancing the fluid quantitative evaluation of fluids by more effectively restoring subsurface geological conditions.This paper presents a current synthesis and forward-looking perspective on experimental techniques supporting shale oil exploration,aiming to guide future research and technological innovation in this field. 展开更多
关键词 Experimental technique Shale oil Reservoir space Mineral analysis Fluid characterization Qualitative and quantitative analysis
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Stiffness evaluation and experimental test of a novel redundantly actuated parallel machining robot 认领 引用
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作者 Hanliang Fang Jian Wang +2 位作者 Shuyi Ge Fufu Yang Jun Zhang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第1期413-422,共10页
Parallel machining robot is a new type of robotized equipment for high-efficiency machining structural com-ponents with complex geometries.Terminal rigidity is of great importance index for such type of equipment,whic... Parallel machining robot is a new type of robotized equipment for high-efficiency machining structural com-ponents with complex geometries.Terminal rigidity is of great importance index for such type of equipment,which affects their load capacity and working accuracy.Before a parallel machining robot can be used for heavy-load and high-efficiency machining,its terminal rigidity should be evaluated systematically.The present study is to quantitatively reveal the stiffness properties of a previously invented Z4 redundantly actuated parallel ma-chining robot(RAPMR).For this purpose,two critical issues,i.e.,stiffness modelling and index construction,are clarified to carry out stiffness evaluation of the Z4 RAPMR.Firstly,drawing on the screw theory,a semi-analytic stiffness model of the proposed RAPMR is established at a component level.Secondly,a set of virtual work-based stiffness indices is constructed to evaluate the terminal rigidity of parallel robots.Those indices have a consistent physical unit in describing linear and angular terminal rigidity.With these indices,the local and the global stiffness performance of the Z4 RAPMR are predicted.Thirdly,a laboratory prototype of the proposed RAPMR is fabricated.And the experimental test is performed to verify the correctness of the established stiffness model.The present work is expected to provide fundamental information for further light-weight design and rigidity enhancement. 展开更多
关键词 Parallel machining robot Redundantly actuated Terminal rigidity Stiffness model Experimental test
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Vibrations induced by time-delayed double blastholes in underground rocks:Experimental study and theoretical analysis 认领 引用
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作者 Yonggang Gou Gui Yang +2 位作者 Xianyang Qiu Kun Ji Yumin Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第2期1108-1125,共18页
Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while... Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while the potential for further vibration reduction remains debated,largely due to unclear underlying mechanisms.In light of the popularization of electronic detonators and the representativeness of double-hole configurationsfor multiple blastholes,it is essential to investigate the vibration characteristics induced by time-delayed double blastholes.Therefore,a series of doubleborehole experimental blasts was conducted in an underground roadway to clarify the variation in vibration from single-hole to dual-hole conditions.Based on the experimental data and inherent limitations,an exact full-fieldtheoretical model was further employed to systematically analyze the effects of delay time,charge length,and borehole inclination angle on vibrations induced by various doublehole configurations.The experimental data and theoretical analysis reveal that the general scaled distance effectively predicts vibrations in delayed blasting but does not reflectvibration reduction.Increasing delay time causes fluctuatingPPVs,which stabilize slightly above single-hole PPVs as delay times exceed a certain value.The delayed blasting primarily reduces near-fieldfrequencies.Longer charge lengths in double boreholes increase PPV levels and attenuation rates within a certain length,and the vibration behavior of combined long and short charge lengths is governed by the long blasthole.Larger blasthole inclination angles enhance vibration amplitude and reduce PPV attenuation rates.Optimizing inclination angles is more critical than adjusting delay times,and parallel boreholes offer the best vibration control. 展开更多
关键词 Vibration of double blastholes Experimental data Theoretical model Delay time Wave superposition
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The diffusion and distribution of CO in confined mine spaces:A scaled experimental model approach 认领 引用
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作者 Gaofeng Shi Sheng Xue +1 位作者 Qingyi Tu Zuheng Zhao 《International Journal of Coal Science & Technology》 SCIE EI CAS CSCD 2026年第1期84-97,共14页
Diesel vehicles are the primary mode of transportation in underground coal mines,widely used in mining regions such as Inner Mongolia and Shaanxi Province,China.However,their extensive use has led to growing concerns ... Diesel vehicles are the primary mode of transportation in underground coal mines,widely used in mining regions such as Inner Mongolia and Shaanxi Province,China.However,their extensive use has led to growing concerns over diesel exhaust pollution in confined mine spaces.Carbon monoxide,a major pollutant in diesel exhaust,often results in localized concentrations exceeding 24 ppm,posing significant health risks to coal miners.This study utilizes a self-developed diesel exhaust experimental platform,with air speed as the variable,to investigate the characteristics of exhaust distribution under varying conditions.It also explores the diffusion and transport mechanisms of exhaust from diesel vehicles.The results demonstrate that CO concentration decreases with increasing distance from the exhaust source,following a"three-region"pattern.In Region I,molecular motion and concentration gradients cause a rapid reduction in CO.In Region II,convection and diffusion further dilute the CO,while in Region III,the concentration stabilizes and becomes more evenly distributed.These changes are attributed to the unique operational conditions of diesel vehicles and the fluid dynamics of exhaust diffusion.High concentrations of CO accumulate near the exhaust pipe,where dilution is slow.However,increased air speed accelerate CO reduction,with concentrations continuing to decrease as the distance from the exhaust outlet increases.The CO concentration was observed to decrease from 95.1 ppm to 9.5 ppm,a reduction of 90.01%.Comparisons of field and experimental data confirm the reliability of the experimental platform.These findings highlight the diffusion and jetting effects of CO concentration and offer engineering guidance for CO management in vehicle exhaust in coal mines. 展开更多
关键词 CO diffusion Diesel engine exhaust Confined spaces Experimental model Mine ventilation
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Preliminary XFEL Experimental Simulation Platform Based on HSWAP Engine 认领 引用
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作者 LIU Jin DUAN Bowen +5 位作者 WEI Tao KANG Xu ZHAO Shicao DU Liangliang DENG Xiaoliang LI Xiaoya 《高压物理学报》 CAS CSCD 北大核心 2026年第6期42-51,共10页
X-ray free electron laser(XFEL)plays a critical role in diagnosing dynamic compression processes in micro-and meso-scale materials.To deepen our understanding of XFEL physics and optimize facility design,a preliminary... X-ray free electron laser(XFEL)plays a critical role in diagnosing dynamic compression processes in micro-and meso-scale materials.To deepen our understanding of XFEL physics and optimize facility design,a preliminary XFEL experimental simulation platform was developed based on the highperformance computing(HPC)simulation workflow application platform(HSWAP).HSWAP provides workflow,component,and data linkage models for XFEL experiments,enabling flexible simulation of diverse processes through modular configurations.This platform was employed to investigate X-ray diffraction(XRD)of microscale materials and phase contrast imaging(PCI)of meso-scale explosive samples.Simulation results for XRD of a metallic sample under shock loading and PCI of voids in explosive materials demonstrate the platform’s ability to accurately reproduce experimental dynamics.By integrating numerical models with data analysis,the platform enhances the design of XFEL experiments and provides a foundation for interpreting diagnostic capabilities in ultrafast processes.Future work will focus on refining simulation methods for meso-scale samples using phase-field approaches and high-Z materials under shock conditions. 展开更多
关键词 XFEL experimental simulation platform HSWAP engine X-ray diagnostics
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Simulation and experimental analysis of the grease injection process in the main drive seal lubrication structure of tunnel boring machines 认领 引用
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作者 Zheming TONG Yuchen ZHAO +3 位作者 Lianhui JIA Xiaolei ZHOU Haoxiang LU Wenqi NIU 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2026年第5期479-492,I0009-I0021,共14页
During the excavation process of tunnel boring machines(TBMs),the manufacturing precision and assembly accuracy of components affect the sealing performance of the main drive lubrication system and the service life of... During the excavation process of tunnel boring machines(TBMs),the manufacturing precision and assembly accuracy of components affect the sealing performance of the main drive lubrication system and the service life of the main bearings.Simulating grease injection and pressure distributions in the lubrication chamber helps improve sealing performance and extend the lifespan of the main drive system.This study integrates volume of fluid multiphase flow simulations and experimental investigations to systematically analyze the effects of different eccentricities,the number of grease injection ports,and the inner wall rotation speed on EP2 grease distribution.When the eccentricity between the inner and outer seal axes is within 0.75 mm,the number of external grease injection ports is increased,and the inner wall rotation speed decreases,the grease is evenly distributed in the flow channels.An injection optimization strategy based on pressure monitoring is proposed.In the design of the main drive sealing structure,controlling the eccentricity below 0.75 mm and arranging 12 injection ports along a single chamber while setting the inner wall rotation speed to 5 r/min can effectively improve the sealing performance of the main drive system. 展开更多
关键词 Tunnel boring machine(TBM) Main drive seal lubrication structure EP2 injection Experimental analysis on grease optimization
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Optimized Design of Cu-Ni-Co-Si Alloy Combining Machine Learning and Experimental Feedback 认领 引用
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作者 Shifang Li Jiachen Han +1 位作者 Zhu Xiao Zhou Li 《Rare Metals》 SCIE EI CAS CSCD 2026年第4期563-578,共16页
The machine learning method was employed to accelerate alloy design,and experimental feedback was provided to enhance predictive accuracy.A Cu-2.7Ni-1.0Co-0.8Si alloy with superior properties was selected using a doub... The machine learning method was employed to accelerate alloy design,and experimental feedback was provided to enhance predictive accuracy.A Cu-2.7Ni-1.0Co-0.8Si alloy with superior properties was selected using a double-objective optimization algorithm.The microstructure and properties of the designed alloy subjected to thermomechanical treatment were investigated systematically.The role of the key alloying element Co was discussed via first-principles calculations.The results showed that the designed alloy exhibited favorable comprehensive properties,with a microhardness of 283 HV,a tensile strength of1006 MPa,and an electrical conductivity of 41.3%IACS.The strength was mainly attributed to the combined effects of dislocation strengthening and precipitation strengthening,whereas the electrical conductivity was primarily limited by the solubility of solute atoms.The addition of an appropriate content of Co accelerated precipitation and increased the volume fraction of the precipitates,thereby synergistically enhancing the mechanical properties and electrical conductivity.This was attributed to the effect of Co on increasing the vacancy binding energy and decreasing the formation enthalpy of the precipitates. 展开更多
关键词 Cu‑Ni‑Co‑Si alloys experimental feedback first‑principles calculations machine learning
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Exploring the soothing and reparative effects of Prinsepia utilis Royle oil based on network pharmacology and experimental validation 认领 引用
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作者 Daohuan Yuan Rui He Jiajia Tian 《Journal of Dermatologic Science and Cosmetic Technology》 2026年第2期55-61,共7页
Background:Current interventions for sensitive skin hyperreactivity mainly target skin barrier restoration and inflammation relief.Natural plant extracts represented by Prinsepia utilis Royle oil contain abundant puri... Background:Current interventions for sensitive skin hyperreactivity mainly target skin barrier restoration and inflammation relief.Natural plant extracts represented by Prinsepia utilis Royle oil contain abundant purified bioactive substances,whose functional mechanisms have become a hot research focus in cosmetic development.Objective:This research combined network pharmacology and in vitro/vivo experiments to verify the soothing and barrier-repairing cosmetic efficacy of Prinsepia utilis Royle oil,laying theoretical support for its application in sensitive skin care products.Materials and Methods:We screened anti-inflammatory and reparative active constituents of Prinsepia utilis Royle oil and their potential targets.Skin inflammation and repair-related targets were retrieved from GeneCards,and overlapping targets of active compounds and skin disease targets were visualized via Venn diagrams.PPI network,GO and KEGG enrichment analyses were conducted to interpret molecular interactions.Cell tests on P815 mast cells and zebrafish model assays were performed to detect NF-κB,histamine,TNF-α,OCLN levels and tail fin wound repair capacity for efficacy verification.Results:Palmitic acid,oleic acid,linoleic acid and vitamins are dominant components of Prinsepia utilis Royle oil.A total of 11 intersecting core targets were screened,among which AKT1,EGFR and TNF with high connectivity dominate skin inflammatory regulation and tissue repair.Enrichment analyses uncovered key functional terms and T cell receptor signaling pathways underlying its soothing activity.Cellular and zebrafish experiments proved that the oil remarkably suppresses pro-inflammatory mediators and accelerates wound recovery.Conclusions:Prinsepia utilis Royle oil exerts anti-inflammatory and repairing effects by regulating core targets including AKT1,EGFR and corresponding signaling pathways.Cellular and zebrafish experiments confirm its cosmetic soothing and barrier-protective effects,showing promising prospects for sensitive skin cosmetics.Further biological and clinical trials are still needed for deeper validation. 展开更多
关键词 Prinsepia utilis Royle Network pharmacology Soothing Reparative Experimental verification
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Experimental and numerical study on PU-coated RC arches subjected to underwater contact explosions 认领 引用
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作者 Xinyu Liu Guangdong Yang +3 位作者 Yong Fan Tao Zhou Gaohui Wang Shengyong Ding 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第7期216-233,共18页
Reinforced concrete(RC)arches,which are widely used in various engineering fields,suffer from severe damage when subjected to blast loads.The damage and dynamic response of concrete structures under underwater explosi... Reinforced concrete(RC)arches,which are widely used in various engineering fields,suffer from severe damage when subjected to blast loads.The damage and dynamic response of concrete structures under underwater explosion(UNDEX)loading are significantly greater than those under air-blast conditions.This study designed and fabricated three RC arches to investigate the protective effectiveness of poly-urea(PU)coatings on RC arches under underwater contact explosion(UNDCEX)loading.UWDCEX tests were conducted using 6 g of TNT explosives to evaluate the effects of the PU coating applied on the back surface and on the double surfaces of the arches.A multi-material dynamic coupling model involving air,water,explosive,RC arch,and PU was also developed based on the arbitrary Lagrangian-Eulerian method.The numerical model was validated through experimental results.The protective perfor-mance of three different reinforcement methods was investigated based on the validated model;these methods included reinforcement on the back,front,and double surfaces.The results derived from analyses of shock wave propagation,dynamic response,energy dissipation,and damage distributions,revealed that PU coating on the back surface significantly reduced the dynamic response of the arch and the crack width at the arch hance.Further,it enhanced flexural stiffness,mitigated overall deformation,and limited debris generation under UNDCEX.The PU coating on the front surface absorbed a consid-erable portion of the shock wave energy and delayed its transmission to the RC arch.Finally,double surfaces coating offered the most effective protection. 展开更多
关键词 RC arch PU coating Underwater contact explosion Experimental investigation Numerical simulation
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Experimental determination of liquidus projection in Cu-Sb-Te system for thermoelectric material design 认领 引用
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作者 LIU Dong-sheng XU Li-ping +2 位作者 ZHENG Tao-wen HE Cui-yun HUANG Dan-dan 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第5期2005-2026,共22页
The Cu-Sb-Te system has attracted keen interest because of the existence of Cu2Te,Cu4Te3,Sb2Te3,etc.,which show extraordinary properties in thermoelectricity.This work establishes the first complete exp... The Cu-Sb-Te system has attracted keen interest because of the existence of Cu2Te,Cu4Te3,Sb2Te3,etc.,which show extraordinary properties in thermoelectricity.This work establishes the first complete experimental liquidus projection of the Cu-Sb-Te system based on the microstructural and compositional analysis of a series of key as-cast alloys.Key findings include:12 primary solidification fields:(Cu),(Sb),(Te),Sb2Te3,CuTe,Cu4Te3,ζ/ε-Cu2Te,γ-(Sb,Te),δ-(Sb,Te),β-Cu3Sb,η-Cu2Sb and ternaryτ-Cu2SbxTe1-x;a Cu-rich liquid immiscibility dome;13 invariant reactions including 3 eutectic reactions(E type),8 transition reactions(U type),1 peritectic reaction(P type),and a dual-liquid invariant reaction.The projection provides a diagram foundation for designing Cu-Te thermoelectrics. 展开更多
关键词 liquidus projection Cu-Sb-Te system phase diagram experimental investigation egg-shaped microstructure liquid immiscibility dome
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Experimental testing and finite element analysis of the tensile response of toothed flange connections 认领 引用
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作者 Pantelis MATIS Tony MARTIN +6 位作者 Patrick MCGETRICK Su TAYLOR Debra LAEFER Salam AL-SABAH Linh TRUONG-HONG Arturo SCHULTZ Mohammad SHEMSHADIAN 《ENGINEERING Structure and Civil Engineering》 SCIE EI CAS CSCD 2026年第6期1158-1174,共17页
Modern steel erection relies on two main connection methods,welding and bolting,which can be expensive field activities and have remained unchanged for nearly a century.To achieve savings in both weight and cost,incre... Modern steel erection relies on two main connection methods,welding and bolting,which can be expensive field activities and have remained unchanged for nearly a century.To achieve savings in both weight and cost,increased construction effectiveness and higher steel reuse,a novel type of toothed steel connections with the use of precise,advanced manufacturing methods in waterjet or laser cutting has been established that is based on an interlocking approach to connect steel components that have exactly cut ends.This paper presents testing and finite element analysis(FEA)studies of three unique flange plate geometries of the toothed steel connections failing in tension.Tensile tests were carried out on six samples of the toothed flange connections for each of the three geometries and the digital image correlation(DIC)method was utilized to attain axial displacement.The observed key test results,including load–displacement responses,yield loads,failure loads and modes,were fully presented.Strain contours of the connection geometries with the use of the DIC technique at early stage loading and near ultimate failure were also presented.The experimental program was accompanied with a numerical modeling program,in which finite element models were first created in Abaqus structural analysis software and compared against the test results.Based on the tests and numerical data,the performance and the capacity of the three unique flange connections were assessed.The FEA results agreed very well with the test results,indicating that the numerical simulations can accurately predict yield,ultimate load capacities and failure modes of the toothed connections.The numerical models characterized thoroughly the predicted stress distributions within the connections.For capacity-based design,the second flange connection(CON2)geometry could be adopted in beam tensile zones due to its better overall performance. 展开更多
关键词 finite element modelling experimental testing toothed steel connection contact advanced manufacturing techniques structural steel
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Experimental assessment of the predation pressure by the exotic flatworm Obama nungara in its introduced range 认领 引用
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作者 Shanèze Noël Yoan Fourcade +2 位作者 Virginie Roy Agnès Gigon Lise Dupont 《Current Zoology》 SCIE CAS CSCD 2026年第1期69-80,共12页
Land planarians are carnivorous predators that feed mainly on soil macrofauna such as earthworms,gastropods,and other land planarians.Several land planarian species have become invasive worldwide and pose a threat to ... Land planarians are carnivorous predators that feed mainly on soil macrofauna such as earthworms,gastropods,and other land planarians.Several land planarian species have become invasive worldwide and pose a threat to soil biodiversity.Among them,Obama nungara is one of the most abundant invasive species found in France.The aim of this study was to investigate the predation frequency,growth rate,and preferential predation of O.nungara using an experimental approach.O.nungara’s predation was tested on 8 prey species found in its French-introduced area.Two types of experiments were carried out:single experiments,where one O.nungara was offered 3 prey items of the same species and mixed experiments,where one O.nungara was offered 3 prey items of different species at the same time.We showed that O.nungara feeds equally on earthworms,snails,and slugs and that they can also prey on another introduced land flatworm,native to Australia:Caenoplana variegata.This ability to prey on a wide variety of native prey and to thrive on a mixed or single diet demonstrates its opportunistic feeding behavior,a likely predominant factor in O.nungara’s invasiveness.In addition,long-term observations of O.nungara specimens revealed that they can live up to 10 months,are able to shrink to survive starvation,and can produce egg capsules after several weeks in isolation,which may also positively influence their invasion success. 展开更多
关键词 experimental sciences invasive species Obama nungara predation
Right patient approach to experimental stromal cell therapies for gastrointestinal tumors 认领 引用
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作者 Francesca Vescio Silvia Curcio +2 位作者 Isabella Aquila Michele Ammendola Alessandro Pasquale Tarallo 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第1期282-286,共5页
Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and com... Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding. 展开更多
关键词 Experimental therapies Surgery Non-standardized treatment Gastrointestinal tumor Informed consent
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A2 astrocyte polarization mediates ketogenic diet protection of blood-central nervous system barriers in experimental autoimmune encephalomyelitis 认领 引用
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作者 Qianye Zhang Mingxiao Zheng +3 位作者 Hans-Christian Siebert Qingpeng Wang Ruiyan Zhang Ning Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4457-4473,共17页
Disruption of the blood-brain barrier and blood-spinal cord barrier is a fundamental pathological feature of multiple sclerosis progression.The ketogenic diet has a high therapeutic potential for patients with multipl... Disruption of the blood-brain barrier and blood-spinal cord barrier is a fundamental pathological feature of multiple sclerosis progression.The ketogenic diet has a high therapeutic potential for patients with multiple sclerosis.We previously reported that treating experimental autoimmune encephalomyelitis mice with ketogenic diet results in anti-neuroinflammation and neuroprotection.However,the impact of ketogenic diet administration on the blood-brain barrier/blood-spinal cord barrier in MS remains unclear.Here,we investigated the effects of ketogenic diet on the blood-brain barrier/blood-spinal cord barrier integrity and the possible underlying mechanisms.We established a 24-day continuous experimental autoimmune encephalomyelitis mouse model with or without ketogenic diet and performed β-hydroxybutyrate assay kit histological analysis,quantitative reverse transcription-polymerase chain reaction,and western blot to examine experimental autoimmune encephalomyelitis pathological hallmarks,glial cell activation status,and intracellular signaling pathway alterations.Our results showed that ketogenic diet inhibited demyelination,suppressed astrocyte and microglial activation,and modulated the balance of matrix metalloproteinasesissue inhibitors of metalloproteinases in the central nervous system of experimental autoimmune encephalomyelitis mice.Ketogenic diet upregulated tight junction proteins(occludin,claudin-1,and ZO-1) and adherens junction proteins(VE-cadherin and β-catenin) in the spinal cord,cerebellum,and cortex of experimental autoimmune encephalomyelitis mice.Notably,we found that ketogenic diet protects the blood-brain barrier/blood-spinal cord barrier integrity by modulating astrocyte polarization from the A1 phenotype to A2 phenotype and modifying the inflammatory milieu(downregulating pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin-1β,and interleukin-6,and upregulating anti-inflammatory cytokines such as transforming growth factor-β and interleukin-4) by inhibition of class I histone deacetylase 3/STAT3uclear factor kappa B(NF-κB)/NOD-,LRR-and pyrin domain-containing protein 3 and activation of PI3K/AKT signaling pathways.Furthermore,ketogenic diet downregulated key chemokines(C-X-C motif chemokine ligand 10,C-X-C motif chemokine ligand 12,C-C motif chemokine ligand 2,and C-C motif chemokine ligand 5) and receptor C-C motif chemokine receptor 2 expression throughout the central nervous system,suggesting an impaired capacity for leukocyte recruitment.Ketogenic diet suppressed astrocytic NOD-,LRR-and pyrin domain-containing protein 3 inflammasome activation,as evidenced by reduced NOD-,LRR-and pyrin domain-containing protein 3/glial fibrillary acidic protein co-localization.In summary,the ketogenic diet promotes neuroprotection in the experimental autoimmune encephalomyelitis model by inhibiting A1 astrogliogenesis and protecting the integrity of the blood-brain barrier/blood-spinal cord barrier. 展开更多
关键词 A1 astrocytes A2 astrocytes blood-brain barrier blood-spinal cord barrier experimental autoimmune encephalomyelitis ketogenic diet multiple sclerosis nerve regeneration neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)inflammasome
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Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model 认领 引用
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作者 Alexandra G Marneri Efstathios T Pavlidis +8 位作者 Kalliopi E Stavrati Athanasios Kofinas Christina Mouratidou Ioannis Gkoutziotis Serafeim-Chrysovalantis Kotoulas Christina Marouda Dimitra Psalla Konstantinos D Ballas Theodoros E Pavlidis 《World Journal of Experimental Medicine》 2026年第1期232-248,共17页
BACKGROUND In addition to their primary lipid-lowering effects,statins also exhibit pleiotropic properties,including anti-inflammatory,immunomodulatory,antimicrobial,antioxidative,and angiogenic effects,all of which p... BACKGROUND In addition to their primary lipid-lowering effects,statins also exhibit pleiotropic properties,including anti-inflammatory,immunomodulatory,antimicrobial,antioxidative,and angiogenic effects,all of which promote wound healing.Rosuvastatin,a synthetic hydrophilic statin,has recently been proposed to enhance wound healing by stimulating angiogenesis and accelerating tissue regeneration.Its hydrophilic nature,longer half-life,greater hepatoselectivity,and better efficacy/safety than other statins are believed to contribute to its superior efficacy in wound repair,as suggested by promising preliminary results.However,current data on its use remain limited,necessitating further preclinical and clinical studies to thoroughly investigate this novel treatment option for burns.AIM To investigate the effects of rosuvastatin and its mechanism of action on burn wound healing process in an experimental study.METHODS Ninety male Wistar albino rats aged 12-16 weeks were randomly assigned to three groups of 30,subjected to burn using specific stainless steel sealer.Burn eschar was removed the following day applying topical rosuvastatin cream(study),Eucerin cream(placebo),normal saline(control),and sterile wound dressing.Each group was divided into three subgroups of ten according to sacrifice day(3rd,6th,9th).C-reactive protein(CRP),tumor necrosis factor-alpha(TNF-α),interleukin(IL)-1β,IL-6,digital assessment of burn healing,and histopathology were performed.RESULTS Using the value on the third day in the control group as the baseline,reductions were measured on the sixth and ninth days.Similarly,reduction values were recorded on the third,sixth,and ninth days in the study group.A statistically significant reduction was observed in the study group compared to the control group,with greater reductions corresponding to later sacrifice days(3rd,6th,and 9th)in CRP(P<0.01),TNF-α(P<0.01),IL-1β(P<0.01),and IL-6(P<0.01)levels and burn size(P<0.01).Histopathology revealed a statistically significant reduction in inflammatory infiltration,coagulative necrosis,and microhemorrhage(P<0.01).Conversely,statistically significant increases in neovascularization(P=0.012)and fibroblastic reactions(P=0.023)were noted.No adverse effects or deaths were observed.CONCLUSION Rosuvastatin reduces inflammation by lowering TNF-α,IL-1β,IL-6,CRP while increasing neo-angiogenesis,fibroblast reactions and microenvironmental protection in burn wounds.These effects promote repair and positively impact burn wound healing. 展开更多
关键词 Experimental skin burns Statins Rosuvastatin Burn wound healing Skin burn treatment Inflammation Antiinflammatory rosuvastatin action
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Experimental Analysis of Underground Wireless Charging Based on Backscatter-Assisted Distributed Beamforming 认领 引用
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作者 Zhang Huaijin Liu Guanghua +2 位作者 Liao Changzhen Wang Jintao Jiang Tao 《China Communications》 SCIE EI CSCD 2026年第5期85-95,共11页
In order to avoid frequent manual replacement of underground sensor node batteries,many researches have been devoted to the realization of wireless powered underground sensor networks(WPUSNs).However,existing schemes ... In order to avoid frequent manual replacement of underground sensor node batteries,many researches have been devoted to the realization of wireless powered underground sensor networks(WPUSNs).However,existing schemes mainly focus on the design of routing protocols and network topologies,failing to address the challenge of activating energy harvesting circuits.To this end,we propose a backscatter-assisted distributed beamforming-based WPUSN(B2-WPUSN).The key insight of B2-WPUSN is utilizing backscatter to acquire the accurate channel state information(CSI)and designing the corresponding beamforming vector to concentrate the energy until it exceeds the startup threshold of the node.In particular,since backscatter causes additional attenuation,we use a LoRa signal,whose high sensitivity ensures correct channel estimation.We prototype B2-WPUSN on universal software radio peripheral(USRP)radios and evaluate its charging performance in a sandbox.The experimental results show that the average charging time is less than 40 seconds even at a soil moisture of 15%. 展开更多
关键词 backscatter distributed beamforming experimental underground wireless charging wireless powered underground sensor networks(WPUSNs)
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Experimental Validation of a Fully Coupled Frequency-Domain Method for Global Response Analysis of Floating Wind Turbines 认领 引用
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作者 CHEN Peng LI Chang-en +3 位作者 DENG Shi CHENG Zheng-shun Gareth ERFORT HU Zhi-qiang 《China Ocean Engineering》 SCIE EI CSCD 2026年第2期250-260,共11页
The design of floating wind turbines(FWTs)requires comprehensive consideration of complex marine environments and coupled responses among various components.The efficiency of current time domain simulation methods rem... The design of floating wind turbines(FWTs)requires comprehensive consideration of complex marine environments and coupled responses among various components.The efficiency of current time domain simulation methods remains insufficient for design and optimization in the early stages of FWT development.This study validates a proposed frequency domain(FD)modeling method through code-to-experiment comparison.The FD method incorporates fundamental assumptions about the FWT model,including representing the FWT tower as a nonlinear beam and modeling the rotor-nacelle assembly(RNA)and floating platform as rigid bodies positioned at each end of the tower.The method incorporates excitation loads using blade element momentum theory,linear potential flow theory,and quasistatic catenary theory for aerodynamic,hydrodynamic,and mooring dynamics,respectively.Validation involves a code-to-experiment comparison through a basin model test utilizing a 1/50 scaled semi-submersible platform equipped with a 5MW wind turbine.The results demonstrate strong correlation with experimental data regarding mean response and power spectral density of platform and nacelle motions.The overall discrepancy for these physical quantities remains below 10%.Specifically,the mean discrepancy of platform surge and pitch motions under combined wind and wave conditions measures 1.05%and 3.91%,respectively.This validation confirms the viability of the proposed FD method,offering substantial technical support for early-phase analysis and optimization of FWT.The validation results contribute significantly to advancing FWT design and optimization understanding. 展开更多
关键词 floating wind turbine frequency-domain wave basin experiment experiment validation
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Experimental investigation of contour blasting in anisotropic rocks under different lateral stress coefficients 认领 引用
20
作者 PENG Si-yu LI Xi-bing +2 位作者 LIU Hui-lin WANG Zhao-wei LIANG Li-sha 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第3期1242-1259,共18页
This study aims to analyze the influence of lateral stress coefficient k and anisotropy on the dynamic response and failure characteristics of deep jointed rock masses under contour blasting.Using phyllite as the test... This study aims to analyze the influence of lateral stress coefficient k and anisotropy on the dynamic response and failure characteristics of deep jointed rock masses under contour blasting.Using phyllite as the test material,local contour blasting-unloading experiments are conducted under biaxial conditions.The analysis focuses on the failure characteristics of the tunnel surrounding rock under different k and joint orientations.Results indicate that when k=1,blasting-induced fractures preferentially propagate along the joint direction.As k decreases,these fractures can deviate from the joint direction and extend toward zones of higher local stress.This tendency is particularly evident when the high-stress direction aligns with the tunnel contour,enabling fracture penetration through closely spaced contour blastholes.During the unloading,blasting-induced circumferential fractures undergo further shear failure,while radial fractures are compacted and closed.The failure of tunnel sidewalls is primarily controlled by circumferential stress concentration and anisotropic compressive strength,whereas failure at the tunnel crown is mainly governed by blasting stresses and the anisotropic tensile strength of the rock mass.This study proposes conditions for the initiation and coalescence of blasting-induced fractures,providing a theoretical basis for contour blasting and support design in anisotropic rock masses. 展开更多
关键词 laboratory experiment contour blasting excavation unloading failure characteristics lateral stress coefficient anisotropic rocks
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