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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury 认领 引用 被引量：4
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作者 Fanzhuo Zeng Yuxin Li +6 位作者 Xiaoyu Li Xinyang Gu Yue Cao Shuai Cheng He Tian Rongcheng Mei Xifan Mei 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期365-376,共12页
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s... Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury. 展开更多
关键词 angiogenesis apoptosis brain-derived neurotrophic factor colony stimulating factor 1 receptor inflammation microglia motor function spinal cord injury vascular endothelial growth factor
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Organelle symphony:Nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in stroke pathobiology 认领 引用 被引量：2
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作者 Ziliang Hu Mingyue Zhao +4 位作者 Hangyu Shen Liangzhe Wei Jie Sun Xiang Gao Yi Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1483-1496,共14页
Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is cha... Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is characterized by bleeding within the brain.Stroke is a lifethreatening cerebrovascular condition characterized by intricate pathophysiological mechanisms,including oxidative stress,inflammation,mitochondrial dysfunction,and neuronal injury.Critical transcription factors,such as nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B,play central roles in the progression of stroke.Nuclear factor erythroid 2-related factor 2 is sensitive to changes in the cellular redox status and is crucial in protecting cells against oxidative damage,inflammatory responses,and cytotoxic agents.It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function,endoplasmic reticulum stress,and lysosomal activity and regulating metabolic pathways and cytokine expression.Conversely,nuclear factor-kappa B is closely associated with mitochondrial dysfunction,the generation of reactive oxygen species,oxidative stress exacerbation,and inflammation.Nuclear factor-kappa B contributes to neuronal injury,apoptosis,and immune responses following stroke by modulating cell adhesion molecules and inflammatory mediators.The interplay between these pathways,potentially involving crosstalk among various organelles,significantly influences stroke pathophysiology.Advancements in single-cell sequencing and spatial transcriptomics have greatly improved our understanding of stroke pathogenesis and offer new opportunities for the development of targeted,individualized,cell typespecific treatments.In this review,we discuss the mechanisms underlying the involvement of nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in both ischemic and hemorrhagic stroke,with an emphasis on their roles in oxidative stress,inflammation,and neuroprotection. 展开更多
关键词 inflammation nuclear factor erythroid 2-related factor 2 nuclear factor-kappa B organelles oxidative stress stroke
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Interferon regulatory factor 1 enhances T cell differentiation in patients with myasthenia gravis 认领 引用 被引量：1
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作者 Yuebei Luo Yijun Ren +3 位作者 Zeyi Wen Zhaohui Luo Huan Yang Liqun Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3267-3280,共14页
Interferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis.However,its function in myasthenia gravis remains unclear.Herein,we explored the function of... Interferon regulatory factor 1 is involved in many autoimmune conditions and is increased in patients with myasthenia gravis.However,its function in myasthenia gravis remains unclear.Herein,we explored the function of interferon regulatory factor 1 in myasthenia gravis,with an aim to understand the underlying mechanisms.Patients with myasthenia gravis who had acetylcholine receptor antibodies were included in the study.Peripheral blood lymphocytes were extracted from the included patients,and B lymphocyte subsets were isolated.Next,T and B cells from peripheral blood were co-cultured to explore the interferon regulatory factor 1-related mechanisms in myasthenia gravis.Chromatin immunoprecipitation experiments confirmed an interaction between interferon regulatory factor 1 and the CD180 promoter region.Dual-luciferase reporter gene confirmed the transcriptional activity of interferon regulatory factor 1 on CD180 promoter.In vitro results further indicated that interferon regulatory factor 1 promoted B cell activation and T cell differentiation via the inhibition of CD180.Interferon regulatory factor 1 recruited histone deacetylase 1 to inhibit CD180 transcription.Additionally,histone deacetylase 1 promoted B cell activation and T cell differentiation.Finally,in vitro experiments demonstrated that CD180 inhibited B cell activation and T cell differentiation by inhibiting the Toll-like receptor 4/mitogen-activated protein kinasesuclear factor-kappa B pathway.Collectively,our results suggest that interferon regulatory factor 1 enhances T cell differentiation by recruiting histone deacetylase 1 to block B cell CD180 transcription in myasthenia gravis via the Toll-like receptor 4/mitogen-activated protein kinasesuclear factor-kappa B pathway.Together,these findings indicate the important role of interferon regulatory factor 1 in myasthenia gravis and suggest its molecular mechanisms.They also provide new ideas and targets for diagnosing and treating myasthenia gravis,which will be both scientifically and clinically valuable. 展开更多
关键词 autoimmune condition B cell CD180 histone deacetylase 1 interferon regulatory factor 1 mitogen-activated protein kinase myasthenia gravis nuclear factor-kappa B T cell Toll-like receptor 4
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Auxin Response Factor OsARF13 Positively Regulates Scutellum-Derived Callus Induction Efficiency 认领 引用
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作者 PAN Yidan LI Xiaojun +4 位作者 LI Dandan LIU Zhen FEI Siyi SHU Qingyao GUO Fu 《Rice science》 SCIE CAS CSCD 2026年第2期141-145,I0002-I0020,共5页
The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this ... The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this study,we investigated the role of Oryza sativa AUXIN RESPONSE FACTOR 13(OsARF13),a transcription factor involved in callus-related processes.We observed that OsARF13 expression is significantly higher in japonica rice callus than in indica rice callus.This differential expression might be associated with an allelic variation in the promoter region of OsARF13,where a deletion commonly found in indica rice corresponds to the loss of a conserved auxin-responsive element(AuxRE)motif.To functionally characterize OsARF13,we generated CRISPR/Cas9-mediated knockout mutants.These mutants exhibited a substantial reduction in callus fresh weight,demonstrating that OsARF13 is required for efficient callus induction.Transcriptome analysis of the osarf13 mutant further showed that OsARF13 influences the expression of genes involved in hormone signal transduction and stress responses.Our findings suggest that OsARF13 is a key component of the regulatory network governing callus induction and that natural variation in its promoter might provide a potential explanation for the differential regenerative capacity between japonica and indica rice subspecies. 展开更多
关键词 callus induction transcription factor oryza sativa auxin response factor japonica rice auxin response factor OSARF indica rice
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Techniques and factors for reducing chronic neuropathic pain: A review 认领 引用 被引量：1
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作者 Damien P.Kuffler 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1353-1358,共6页
Nerve trauma commonly results in chronic neuropathic pain. This is by triggering the release of proinflammatory mediators from local and invading cells that induce inflammation and nociceptive neuron hyperexcitability... Nerve trauma commonly results in chronic neuropathic pain. This is by triggering the release of proinflammatory mediators from local and invading cells that induce inflammation and nociceptive neuron hyperexcitability. Even without apparent inflammation, injury sites are associated with increased inflammatory markers. This review focuses on how it might be possible to reduce neuropathic pain by reducing inflammation. Physiologically, pain is resolved by a combination of the out-migration of pro-inflammatory cells from the injury site, the down-regulation of the genes underlying the inflammation, up-regulating genes for anti-inflammatory mediators, and reducing nociceptive neuron hyperexcitability. While various techniques reduce chronic neuropathic pain, the best are effective on < 50% of patients, no technique reliably or permanently eliminates neuropathic pain. This is because most techniques are predominantly aimed at reducing pain, not inflammation. In addition, while single factors reduce pain, increasing evidence indicates significant and longer-lasting pain relief requires multiple factors acting simultaneously. Therefore, it is not surprising that extensive data indicate that the application of platelet-rich plasma provides more significant and longer-lasting pain suppression than other techniques, although its analgesia is neither complete nor permanent. However, several case reports indicate that platelet-rich plasma can induce permanent neuropathic pain elimination when the platelet concentration is significantly increased and is applied to longer nerve lengths. This review examines the primary triggers of the development and maintenance of neuropathic pain and techniques that reduce chronic neuropathic pain. The application of plateletrich plasma holds great promise for providing complete and permanent chronic neuropathic pain elimination. 展开更多
关键词 anti-inflammatory factors axon regeneration inflammatory pain nerve regeneration nerve repair pain elimination pain reduction platelet-rich plasma pro-inflammatory factors restoration of function
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External risk factors for smartphone addiction in adolescents:A systematic literature review 认领 引用
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作者 Wanqing Lin Mohd Azrin Mohd Nasir Suzila Binti Ismail 《Journal of Psychology in Africa》 2026年第1期143-152,共10页
This systematic review synthesizes empirical research on external risk factors for adolescent smartphone addiction.Scopus and Web of Science were searched for English peer-reviewed empirical articles from 2008 onward;... This systematic review synthesizes empirical research on external risk factors for adolescent smartphone addiction.Scopus and Web of Science were searched for English peer-reviewed empirical articles from 2008 onward;28 met inclusion criteria(excluding non-adolescents,generic internet addiction,non-empirical work,or non-English).Thematic synthesis organized findings into three external risk domains—family,school,and peers—considering cultural/contextual mechanisms.Family dynamics(parental phubbing,harsh parenting,dysfunction),school stressors,and adverse peer relationships were identified as accumulating,direct and indirect contributors to smartphone addiction.These operate within a techno-ecological framework,where digital technologies amplify vulnerabilities and create new pathways for maladaptive use.Evidence favors an ecological,multi-level perspective.Future research should use longitudinal designs,standardize measures across cultures,and examine understudied regions—especially Africa—to guide culturally sensitive interventions. 展开更多
关键词 Smartphone addiction adolescent family risk factor school risk factor peer risk factor
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Spatial-temporal landslide hazard analysis considering ecological and hydrological factors 认领 引用
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作者 ZHAO Zheng LAN Hengxing +2 位作者 LI Langping BAO Han LIU Shijie 《Journal of Mountain Science》 SCIE CSCD 2026年第4期1547-1563,共17页
Ecological factors,such as vegetation roots,can enhance soil shear strength,reduce surface runoff erosion,and improve slope stability.Conversely,heavy rainfall can rapidly saturate unsaturated soil,weakening shear str... Ecological factors,such as vegetation roots,can enhance soil shear strength,reduce surface runoff erosion,and improve slope stability.Conversely,heavy rainfall can rapidly saturate unsaturated soil,weakening shear strength.As such,both ecological and hydrological processes play critical roles in shallow slope failures.In this study,we propose a spatialtemporal landslide hazard model considering ecological and hydrological factors.Specifically,ecological factors are incorporated in convolution neural network as a spatial probability module,and hydrological factors are involved in infinite slope hydrological model as a temporal probability module,finally we integrated the spatial-temporal probabilities using integration module.A case study in the Hengduan Mountain Region demonstrated that the proposed model outperforms traditional models by achieving higher prediction accuracy,with an increase in the landslide hit index,demonstrating the effectiveness of involving ecological and hydrological factors in landslide hazard analysis,offering practical suggestions for landslide risk management. 展开更多
关键词 Landslide hazard Spatial probability Temporal probability Ecological factor Hydrological factor
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Which factors can influence budgerigars’feeding behavior under predation risk:individual and/or social factors? 认领 引用
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作者 Xueqi Zhao Jie Su +2 位作者 Manxi Lu Jiangping Yu Haitao Wang 《Current Zoology》 SCIE CAS CSCD 2026年第4期557-567,共11页
Animals face a fundamental risk-reward trade-off when making feeding decisions in the presence of predation.This tradeoff requires balancing time spent being vigilant with time spent feeding under predation risk,influ... Animals face a fundamental risk-reward trade-off when making feeding decisions in the presence of predation.This tradeoff requires balancing time spent being vigilant with time spent feeding under predation risk,influenced by both individual and social factors.However,it remains unclear which factor plays a more significant role.In this study,we aimed to determine whether individual factors(sex,personality,and body condition)and social factors(social familiarity and social rank)influence feeding and vigilance behaviors under predation risk.When alone with the predator,budgerigars with longer tarsus length exhibited shorter latency to feed,and bold budgerigars tended to have a lower frequency of scans,but neophobia and body condition did not influence these behaviors.When facing the predator with familiar group members,individuals showed shorter latency to feed,and a lower frequency of scans compared to when with unfamiliar group members or alone.Moreover,social rank was the most important factor affecting latency to feed.Our findings suggested that both individual and social factors can influence budgerigars’foraging behaviors,with social factors playing a more significant role than individual factors when individuals are in a group. 展开更多
关键词 feeding behaviors individual factors predation risk social factors
Could deciphering cellular-mesenchymal epithelial transition factor/hepatocyte growth factor network dynamics unlock novel biomarker-driven therapies for colorectal cancer? 认领 引用
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作者 Jun-Kai Wen Jing Xia +3 位作者 Lu Yu Guo-Liang Xu Gang-Fu Ye Yu-Hua Lin 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第4期15-33,共19页
Colorectal cancer(CRC)poses a substantial global health challenge.Its pathogenesis involves intricate genetic and signaling pathway aberrations,among which the cellular-mesenchymal epithelial transition factor(c-Met)/... Colorectal cancer(CRC)poses a substantial global health challenge.Its pathogenesis involves intricate genetic and signaling pathway aberrations,among which the cellular-mesenchymal epithelial transition factor(c-Met)/hepatocyte growth factor(HGF)axis functions as a pivotal regulatory hub.Encoded by a proto-oncogene,the transmembrane receptor c-Met is activated by HGF,driving CRC cell proliferation,migration,invasion,and metastasis via critical signal transduction cascades.The c-Met factor overexpression is observed in 30%-70%of CRC tumors.This review elucidates c-Met/HGF-mediated carcinogenesis,emphasizing its crosstalk with epidermal growth factor receptor,vascular endothelial growth factor,and insulin-like growth factor 1 receptor pathways.Notably,c-Met amplification contributes to epidermal growth factor receptor inhibitor resistance,increasing signaling network complexity.MicroRNA-1 and microRNA-137 modulate c-Met expression to suppress CRC progression,while advancements in c-Met-targeted molecular imaging facilitate precise diagnosis and treatment monitoring.Progress in c-Met/HGF-targeted therapies,including small-molecule inhibitors,monoclonal antibodies,and tyrosine kinase inhibitors,shows promise in suppressing tumors and overcoming resistance.Future efforts should focus on optimizing combination therapies,refining patient stratification via imaging,and addressing drug resistance to enable personalized,efficacious CRC treatments leveraging this axis. 展开更多
关键词 Clinical translation Cell signal transduction Colorectal cancer Hepatocyte growth factor Cellular-mesenchymal epithelial transition factor
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Distributions and influencing factors of selenium in soils and edible wild mushrooms and the development and utilization of high-quality wild mushrooms(Boletus,Ramaria botrytoides,Russula virescens) 认领 引用
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作者 Lei Xu Meng-sheng Zhao +5 位作者 Yan-xun Cheng Yao-tang Zhang Ji-yun Guan Fang-fang Lu Chang-wei Linghu Yong-sheng Yuan 《China Geology》 CAS CSCD 2026年第2期290-302,共13页
Selenium(Se)serves as a trace element essential for the human body owing to its significant physiological functions and extensive pharmacological effects.The Se required by the human body is primarily obtained from so... Selenium(Se)serves as a trace element essential for the human body owing to its significant physiological functions and extensive pharmacological effects.The Se required by the human body is primarily obtained from soil-derived foods.This study revealed Se-rich soils covering a certain area and Se-rich edible wild mushrooms with high Se accumulation rates in Chuxiong,central Yunnan Province,China through a geochemical survey of soil quality.Furthermore,this study investigated the Se migration and transformation mechanisms in the soil-wild mushroom system,aiming to provide a scientific basis for the development and planning of Se-rich green foods in the study area.Using the geochemical data of samples collected from topsoils,deep soils,and wild mushrooms and their root soils in Nanhua County,Chuxiong,this study analyzed the Se contents in soils and wild mushrooms and their root soils and explored the mechanisms and influencing factors of Se enrichment in wild mushrooms.The results indicate that the topsoils in the study area exhibit Se contents ranging from 0.07 mg/kg to 0.95 mg/kg,with an arithmetic average of 0.25 mg/kg.The Se-rich soils cover an area of 356 km2,which accounts for 13.07% of the total topsoil area.The wild mushrooms in the study area display Se contents varying from 0.004 mg/kg to 47.10 mg/kg,with a median of 0.977 mg/kg.The analyses of Moran’s index and semivariogram indicate that the Se content distributions in both topsoils and deep soils in the study area exhibit distinct spatial structures.Specifically,the semivariogram model for the Se content in the deep soils emerges as a Gaussian model,and the Se content exhibits a nugget-to-sill ratio of 21.72%,suggesting that the Se content in deep soils is primarily influenced by structural factors such as parent materials.Se in the soils originates primarily from soil-forming parent rocks,with the origin of the Se-rich soils closely related to Triassic black shales,thin coal seams,and metamorphic rocks in the Ailao Mountain area.The wild mushrooms in the study area enjoy significantly higher Se content than other reported naturally Se-rich agricultural products,with a Se accumulation rate of up to 92.31%and an overall over-limit ratio of Pb and Cd of merely 11.54%,suggesting that the study area has substantial potential for the development of naturally Se-rich green foods.The wild mushrooms in the study area exhibit bioconcentration factors(BCFs)of Se ranging from 0.02 to 157.00(median:4.26),with Se bioavailability decreasing in the order of Boletus edulis,Boletus aereus,Leccinum nigrescens,Ramaria botrytoides,and Russula virescens.For the Se absorption and enrichment in the wild mushrooms,the primary controlling factor is identified as the wild mushroom species.Furthermore,they are significantly influenced by the Se content in soils but are minimally affected by the physicochemical indicators of soils. 展开更多
关键词 Selenium Wild mushroom Boletus Ramaria botrytoides Russula virescens Soil Bioconcentration factor Influencing factor Nanhua County Geochemical geological survey engineering Sustainable Development Goals No.1(No Poverty) Sustainable Development Goals No.2(Zero Hunger)
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BCL2-Associated Transcription Factor 1 Promotes SRC/Hypoxia-Inducible Factor 1 Subunitα-Mediated Cancer Stemness in Radioresistant Triple-Negative Breast Cancer 认领 引用
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作者 Yu-Hao Huang Hao-Yeh Chen +5 位作者 Peng-Ju Chien Chun-Yu Chen Shao-Ti Li Hsueh-Te Lee Yueh-Chun Lee Wen-Wei Chang 《Oncology Research》 SCIE 2026年第7期465-483,共19页
Backgrounds:Triple-negative breast cancer(TNBC)is highly aggressive,insensitive to radiotherapy,and exhibits increased cancer stem cell(CSC)properties,contributing to poor patient outcomes.B-cell lymphoma 2(BCL2)assoc... Backgrounds:Triple-negative breast cancer(TNBC)is highly aggressive,insensitive to radiotherapy,and exhibits increased cancer stem cell(CSC)properties,contributing to poor patient outcomes.B-cell lymphoma 2(BCL2)associated transcription factor 1(BCLAF1)is an oncogene in certain cancers,but its role in TNBC is unclear.This study investigated BCLAF1’s involvement in radioresistance and CSC activity in TNBC.Methods:BCLAF1 expression and clinical significance were analyzed using The Cancer Genome Atlas(TCGA)breast cancer dataset.Radioresistant MDA-MB-231 cells were used to examine BCLAF1’s function.Proto-oncogene SRC(SRC)overexpression,BCLAF1 knockdown,dasatinib treatment,and hypoxia inducible factor 1 subunitα(HIF-1α)inhibition were employed to elucidate regulatory mechanisms.CSC activity was assessed using tumorsphere formation assays.Results:Elevated BCLAF1 mRNA levels were associated with advanced pathological and T stages(analysis of variance[ANOVA],p=1.4×10−3)and poorer overall survival by Kaplan–Meier analysis(p=0.021).BCLAF1 expression was positively correlated with SRC signaling pathway-associated genes,including Kirsten rat sarcoma viral oncogene homolog(KRAS),GTPase-activating protein-binding protein 1(G3BP1),and phosphoinositide-3-kinase regulatory subunit 1(PIK3R1).Radioresistant cells exhibited higher BCLAF1 expression.SRC overexpression reduced radiosensitivity,while increasing BCLAF1 levels.BCLAF1 knockdown suppressed tumorsphere formation.Dasatinib decreased BCLAF1,HIF-1α,and stemness proteins,including octamer-binding transcription factor 4(OCT-4),Notch intracellular domain(NICD),and cellular myelocytomatosis oncogene(c-Myc).BCLAF1 knockdown diminished nuclear HIF-1α,and HIF-1αinhibition abrogated BCLAF1-induced tumorsphere formation.Conclusions:BCLAF1 enhances radioresistance and CSC properties in TNBC via SRC-HIF-1αsignaling,suggesting that BCLAF1 is a potential therapeutic target to overcome radioresistance in TNBC. 展开更多
关键词 B-cell lymphoma 2(BCL2)associated transcription factor 1 SRC kinase hypoxia-inducing factor 1subunitα triple negative breast cancer cancer stemness radiation response
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Household Exposure to Secondhand and Thirdhand Smoke and Associated Factors Among Preschool-Aged Children—Beijing Municipality,China,2023 认领 引用
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作者 Yuan Cao Yaohan Meng +4 位作者 Luting Xu Jianhui Shi Jiaxin Dong Lin Xiao Yun Wang 《China CDC weekly》 SCIE CSCD 2026年第22期686-692,共7页
Introduction:Preschool-aged children(3-6 years old)are particularly vulnerable to household tobacco smoke exposure.This study investigated the prevalence of secondhand smoke(SHS)and thirdhand smoke(THS)exposure among ... Introduction:Preschool-aged children(3-6 years old)are particularly vulnerable to household tobacco smoke exposure.This study investigated the prevalence of secondhand smoke(SHS)and thirdhand smoke(THS)exposure among preschoolers in Beijing and identified the associated socioeconomic and behavioral risk factors,including residential area,parental education level,and household structure,to guide targeted prevention and control strategies.Methods:We conducted a cross-sectional survey among 1,839 parents in 2023 using stratified random cluster sampling across 20 kindergartens in Beijing,China.Structured questionnaires were administered to collect data on demographics,tobacco-related knowledge,and household smoking restrictions.Results:The overall prevalence of THS exposure among preschoolers was 41.3%(759/1,839),comprising 21.6%combined SHS-THS exposure and 19.7%isolated THS exposure.Multinomial logistic regression adopted isolated THS exposure as the reference group.Children not co-residing with grandparents[adjusted odds ratio(aOR)=1.33;95%confidence interval(CI):1.01,1.76]and those in households with comprehensive indoor smoking bans(aOR=3.33;95%CI:1.32,8.42)had significantly higher odds of being free from both SHS and THS exposure.Poor parental awareness of tobacco hazards was associated with higher odds of combined SHSTHS exposure(aOR=1.57;95%CI:1.08,2.28).Compared with unrestricted households,both partial indoor smoking bans(aOR=0.28;95%CI:0.13,0.62)and comprehensive bans(aOR=0.06;95%CI:0.03,0.14)were associated with lower odds of combined exposure.Conclusion:THS exposure was highly prevalent among preschoolers in Beijing,China.Notably,while partial smoking bans were associated with lower SHS exposure,only comprehensive indoor smoking bans were associated with lower THS exposure.Public health initiatives should strengthen parental awareness and strictly advocate for smoke-free home environments. 展开更多
关键词 Prevention Strategies tobacco smoke Secondhand Smoke Preschool Aged Children Socioeconomic Factors socioeconomic behavioral risk factorsincluding Thirdhand Smoke Beijing
Variations and major driving factors for soil nutrients in a typical karst region in Southwest China 认领 引用 被引量：2
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作者 Miaomiao Wang Hongsong Chen +1 位作者 Wei Zhang Kelin Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期424-435,共12页
Understanding the spatial distributions and corresponding variation mechanisms of key soil nutrients in fragile karst ecosystems can assist in promoting sustainable development.However,due to the implementation of eco... Understanding the spatial distributions and corresponding variation mechanisms of key soil nutrients in fragile karst ecosystems can assist in promoting sustainable development.However,due to the implementation of ecological restoration initiatives such as land-use conversions,novel changes in the spatial characteristics of soil nutrients remain unknown.To address this gap,we explored nutrient variations and the drivers of the variation in the 0–15 cm topsoil layer using a regional-scale sampling method in a typical karst area in northwest Guangxi Zhuang Autonomous Region,Southwest China.Descriptive statistics,geostatistics,and spatial analysis were used to assess the soil nutrient variability.The results indicated that soil organic carbon(SOC),total nitrogen(TN),total phosphorus(TP),and total potassium(TK)concentrations showed moderate variations,with coefficients of variance being 0.60,0.60,0.71,and 0.72,respectively.Moreover,they demonstrated positive spatial autocorrelations,with global Moran's indices being 0.68,0.77,0.64,and 0.68,respectively.However,local Moran's index values were low,indicating large spatial variations in soil nutrients.The best-fitting semi-variogram models for SOC,TN,TP,and TK concentrations were spherical,Gaussian,exponential,and exponential,respectively.According to the classification criteria of the Second National Soil Census in China,SOC and TN concentrations were relatively sufficient,with the proportions of rich and very rich levels being up to 90.9 and 96.0%,respectively.TP concentration was in the mediumdeficient level,with the areas of medium and deficient levels accounting for 33.7 and 30.1%of the total,respectively.TK concentration was deficient,with the cumulative area of extremely deficient,very deficient,and deficient levels accounting for 87.6%of the total area.Consequently,the terrestrial ecosystems in the study area were more vulnerable to soil P and K than soil N deficiencies.Furthermore,variance partitioning analysis of the influencing factors showed that,except for the interactions,the single effect of other soil properties accounted more for soil nutrient variations than spatial and environmental variables.These results will aid in the future management of terrestrial ecosystems. 展开更多
关键词 dominant factor geostatistics karst ecosystem soil nutrient classification spatial variation
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Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis 认领 引用 被引量：1
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作者 Yu-Nuo Yang Yun-Hong Sun +9 位作者 Ming-Zhe Zhu Yi-Rong Wang Meng Li Kai Wang Jing Ma Li Zhang Dan Hu Wen-Jun Zhou Guang Ji Yan-Qi Dang 《World Journal of Gastroenterology》 SCIE CAS 2026年第17期116-134,共19页
BACKGROUND Qiweizhigan granule(QWZG)is employed in clinical settings for the treatment of metabolic dysfunctionassociated steatohepatitis(MASH).However,the precise biological mechanisms underlying its therapeutic effe... BACKGROUND Qiweizhigan granule(QWZG)is employed in clinical settings for the treatment of metabolic dysfunctionassociated steatohepatitis(MASH).However,the precise biological mechanisms underlying its therapeutic effects are not yet fully elucidated.AIM To assess the efficacy and the mechanism of QWZG against MASH.METHODS Animal models were established,including normal group,a choline-deficient,L-amino acid-defined high-fat diet(CDAHFD)group,and low/medium/high-dose QWZG groups,as well as a rosiglitazone group.Through comprehensive biochemical,histopathological,RNA sequencing,and bioinformatics analyses,galectin 3(LGALS3)was identified as a critical target of QWZG in the treatment of MASH.The level of LGALS3 was quantitatively assessed and validated using Western blotting,real-time quantitative PCR,and immunofluorescence.The role and function of LGALS3 in inflammation and MASH progression were further investigated through gene knockdown,overexpression,iron assay,and transmission electron microscopy.RESULTS QWZG significantly ameliorated liver pathology by reducing steatosis,inflammation,and fibrosis.RNA sequencing analysis identified 1507 co-expressed differentially expressed genes among the CDAHFD,normal,and QWZG groups.Among these,LGALS3 was identified as one of the most significantly altered differentially expressed genes.Both mRNA and protein levels of LGALS3 were elevated in the CDAHFD group compared to the normal group,whereas treatment with QWZG reduced their levels.Analysis of Human Protein Atlas database indicated that LGALS3 was predominantly expressed in Kupffer cells,and was validated by real-time quantitative PCR and immunofluorescence.Furthermore,the level of LGALS3 was significantly increased in lipopolysaccharide-induced RAW264.7 cells,where its overexpression and recombinant LGALS3 protein both significantly enhanced the expression of interleukin-6,interleukin-1β,and tumor necrosis factor-α.LGALS3 overexpression significantly inhibited glutathione peroxidase 4(GPX4)expression,and exacerbated mitochondrial damage,whereas LGALS3 knockdown markedly increased GPX4 level,and significantly reduced the levels of both total iron and ferrous iron.QWZG treatment significantly reduced the levels of malondialdehyde and ferrous iron,increased the levels of superoxide dismutase and glutathione.In addition,QWZG treatment also significantly enhanced GPX4 expression.Mechanistically,LGALS3 knockdown was associated with reduced expression of tumor necrosis factor receptor-associated factor 6(TRAF6)and NOD-like receptor family pyrin domain containing 3,while its overexpression led to increased levels of these proteins.The TRAF6 inhibitor C25-140 effectively reversed the LGALS3-induced alterations in GPX4 expression and iron accumulation.Furthermore,QWZG treatment significantly decreased the levels of TRAF6 and NOD-like receptor family pyrin domain containing 3.CONCLUSION QWZG ameliorated the progression of MASH by modulating ferroptosis through the LGALS3/TRAF6/GPX4 axis. 展开更多
关键词 Qiweizhigan granule Metabolic dysfunction-associated steatohepatitis Galectin 3 Tumor necrosis factor receptorassociated factor 6 Ferroptosis
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A National Follow-up Study on the Effect of Health Protective Factors on Frailty Transition among Older Adults in China 认领 引用 被引量：1
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作者 Jing Shi Ziyi Zhou +12 位作者 Baiyu Zhou Yongkang Tao Yan Cen Luyao Zhang Sainan Li Ying Li Botao Sang Xiangfei Liu Qinan Ma Xuezhai Zeng Pulin Yu Jing Li Deping Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第3期270-284,共15页
Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective fact... Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective factors on frailty transition by constructing a Protection Index(PI)to guide targeted interventions.Methods Data were extracted from the 4th Sample Survey of the Aged Population in Urban and Rural China,including baseline(2017)and follow-up(2019)surveys.Frailty was assessed using the Frailty Index(FI),whereas the PI measured protective factors.Frailty transitions over 2 years were analyzed prospectively.Pearson’s correlation examined the relationship between FI and PI,and logistic regression assessed the effects of PI on frailty transitions.Results This study included 9,093 older adults.FI values increased with age and were higher in women,whereas PI values decreased with age and were higher in men.Over 2 years,56.2%of the participants showed a stable frailty status,14.2%improved,and 29.6%worsened.Negative transitions were more common than positive transitions,with transitions occurring most frequently between adjacent states.The PI was moderately negatively correlated with the FI(r=−0.349,P<0.001).A higher PI was associated with a lower risk of negative transitions among robust and prefrail individuals(OR=0.989,0.981,both P<0.05),but showed no significant effect among those with existing frailty.Conclusion Negative frailty transitions were more common with advancing age.Enhancing PI may help prevent negative frailty transitions among robust and pre-frail older adults,underscoring the value of early interventions. 展开更多
关键词 Frailty transition Frailty Older adults Protective factors Follow-up study National survey
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NAC transcription factor PpNAP4 modulates sucrose accumulation by activating the expression of PpSUS1 and PpSPS2 during peach ripening 认领 引用 被引量：1
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作者 Jieyu Dai Ze Xu +7 位作者 Zhouheng Fang Qiancheng Han Pei Shi Jingwen Zhu Lijun Cao Hangkong Liu Yanan Hu Caiping Zhao 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第6期1318-1330,共13页
Sugars are crucial in determining fruit quality and significantly affect the commercial value.Sucrose is the primary soluble sugar in ripe peach fruit.However,the regulatorymechanism of sucrose synthesis in peach frui... Sugars are crucial in determining fruit quality and significantly affect the commercial value.Sucrose is the primary soluble sugar in ripe peach fruit.However,the regulatorymechanism of sucrose synthesis in peach fruit,especially during natural ripening,remains largely unexplored.This study identified two structural genes of peach(Prunus persica,‘Jinlinghuanglu’),PpSUS1 and PpSPS2,whose expression was strongly correlated with sucrose accumulation.The transcription factors that regulated the expression of these two genes during peach fruit ripening were screened;and three NACs(NAM,ATAF1/2 and CUC2),whose expression also significantly correlated with sucrose accumulation,were identified.Notably,PpNAP4(NAC-like,activated by APETALA3/PISTILLATA)displayed the highest activation activity toward the PpSUS1 and PpSPS2 promoters.The direct binding activity was confirmed using luciferase imaging and electrophoretic mobility shift assays.The sucrose content and expression of sucrose synthesis-related genes significantly increased when PpNAP4 was overexpressed in peach fruit and the tomato nor mutant.Moreover,PpNAP4 functioned synergistically with PpNAP6 to modulate sucrose synthesis,and PpNAP4 targeted its own promoter and feedback-activated its own expression.This research unveils a novel regulatory mechanism controlling sucrose accumulation in peach fruit. 展开更多
关键词 Prunus persica Sucrose NAC transcription factor PpNAP4 PpSUS1 PpSPS2
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Total flavonoid-and nerve growth factor-loaded gelatin-genipin hydrogel improves repair after spinal cord injury 认领 引用 被引量：1
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作者 Yu Liang Deshuang Xi +5 位作者 Yilin Teng Pan Liu Yanbing Feng Qiumei Huang Ming Gao Shaohui Zong 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3122-3129,共8页
Rat nerve growth factor and total flavonoids from hawthorn leaf contribute to the recovery of neurological function after spinal cord injury,including traumatic,non-traumatic spinal cord injuries.However,it remains ch... Rat nerve growth factor and total flavonoids from hawthorn leaf contribute to the recovery of neurological function after spinal cord injury,including traumatic,non-traumatic spinal cord injuries.However,it remains challenging to efficiently deliver nerve growth factor and total flavonoids from hawthorn leaf to spinal cord injury sites,ensure their sustained release,and minimize further damage.In the present study,we chose a biocompatible and biodegradable gelatin as the substrate,which was crosslinked with the natural biological crosslinker genipin to form a gelatin-genipin hydrogel carrier for the slow release of nerve growth factor and total flavonoids from hawthorn leaf in spinal cord injury sites.The prepared gelatin-genipin hydrogel had good injectable properties and photothermal effects.Furthermore,when the hydrogel with 2%genipin,200 ng/mL nerve growth factor,and 320μg/mL total flavonoids from hawthorn leaf was combined with near infrared irradiation,there was a slow release of total flavonoids from hawthorn leaf and nerve growth factor,reduced oxidative stress,an improved inflammatory microenvironment,and accelerated angiogenesis and axonal regeneration via inhibition of the nuclear factor kappa-B signaling pathway,thereby promoting recovery from spinal cord injury.Collectively,our results indicate that this new hydrogel may improve the prognosis of spinal cord injury,and may represent a new strategy for treating spinal cord injury. 展开更多
关键词 composited hydrogel hawthorn leaf total flavonoids nuclear factor kappa-B pathway photothermal effect reactive oxygen species spinal cord injury
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Overexpressing neurogenic differentiation factor 1 in Müller cells improves retinal function after optic nerve crush injury in adult mice 认领 引用 被引量：1
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作者 Liting Zhong Dashuang Yang +5 位作者 Xiu Han Haiyang Cheng Di Xu Wen Li Gong Chen Ying Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3854-3862,共9页
Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells,which ultimately causes vision loss.Notably,current treatments are limited.In the present study,we explored whether neurogenic di... Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells,which ultimately causes vision loss.Notably,current treatments are limited.In the present study,we explored whether neurogenic differentiation factor 1(NeuroD1 or ND1)overexpression in retinal Müller cells may repair the retina after optic nerve crush in mice.Adult mice were subjected to optic nerve crush followed by intravitreal AAV-7m8-GFAP-GFP-ND1 virus injection.Immunofluorescent staining,multi-electrode array recording,electroretinogram,and visual behavior tests were then performed to examine retinal and optic nerve structure and retinal function at various post-optic nerve crush and virus injection times.Western blot analysis and quantitative reverse transcription polymerase chain reaction were performed to explore the possible mechanisms.Compared with the control virus,specific overexpression of ND1 in Müller cells greatly improved the light responses of retinal ganglion cells and retinal neurons in optic nerve crush-injured mice as early as 1-2 weeks post-virus injection and lasted for up to 4 weeks.Neuronal survival in the ganglion cell layer and synaptic connections in the inner retina were slightly improved at 2 weeks;however,visual behavior,retinal ganglion cell survival,and optic nerve structure were not improved.ND1 transiently enhanced glial cell-derived neurotrophic factor expression in the optic nerve crush-injured retina but hardly inhibited retinal inflammation within 2 weeks.Together,our data indicate that ND1 overexpression in Müller cells improves retinal function in the optic nerve crush-injured retina,and suggest that its neuroprotective effect may be caused by enhanced glial cell-derived neurotrophic factor release. 展开更多
关键词 glial cell-derived neurotrophic factor inflammation Müller cell NeuroD1 optic nerve injury retinal ganglion cell synaptic connection
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The regulatory network composed of phytohormones,transcription factors and non-coding RNAs is involved in the flavonoids biosynthesis of fruits 认领 引用 被引量：1
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作者 Xiaoyuan Zheng Xuejiao Zhang Fankui Zeng 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第3期497-508,共12页
Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the reg... Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the regulatory mechanisms governing flavonoid biosynthesis in fruits.Phytohormones are involved in the regulation of flavonoid biosynthesis.The abscisic acid,ethylene,jasmonic acid,cytokinins,and brassinosteroids promote flavonoid biosynthesis,while auxin negatively regulates flavonoid biosynthesis.Subsequently,transcription factors from the MYB,bHLH,WRKY,NAC,and bZIP families are pivotal in regulating flavonoid biosynthesis.In addition,non-coding RNAs(microRNA and lncRNA)also participate in the regulation of flavonoids biosynthesis.MicroRNAs are generally believed to negatively regulate flavonoid metabolism in fruits,while lncRNAs have the opposite effect.Furthermore,the interactions between plant hormones,transcription factors,and non-coding RNAs in fruit flavonoid biosynthesis were analyzed.Ultimately,a foundational regulatory network for fruit flavonoid biosynthesis was hereby established. 展开更多
关键词 Flavonoids biosynthesis Phytohormone Transcription factor Non-coding RNAs Regulation network Fruit
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A phase 2 trial of burosumab for treatment of fibroblast growth factor-23-mediated hypophosphatemia in children and adults with fibrous dysplasia 认领 引用
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作者 Olivia de Jong Zubeyir Hasan Gun +7 位作者 Afua Asante-Otoo Ibrahim I Elbashir Xiaobai Li Babak Saboury Vardit Kram Luis F.de Castro Vivian MacDonald Alison M.Boyce 《Bone Research》 SCIE CAS CSCD 2026年第3期779-787,共9页
Fibrous dysplasia(FD)is a rare disorder associated with fractures and deformities.FD lesions produce excess phosphaturic hormone fibroblast growth factor 23(FGF23),leading to hyperphosphaturia in most patients,and hyp... Fibrous dysplasia(FD)is a rare disorder associated with fractures and deformities.FD lesions produce excess phosphaturic hormone fibroblast growth factor 23(FGF23),leading to hyperphosphaturia in most patients,and hypophosphatemia in those with high FD burden.Skeletal complications are associated with both low-normophosphatemia and frank hypophosphatemia.Burosumab is approved for other forms of FGF23 excess,but there is little evidence to inform use in FD.A phase 2 study investigated the safety and efficacy of burosumab in patients with FD.The primary endpoint was the proportion of participants achieving phosphate levels within the mid to upper part of the normal range(age and sex-adjusted Z-score–1 to+2).12 participants(7 children,5 adults)received burosumab for 48 weeks.Median phosphate Z-score increased from−2.88(1.65)to 0.22(1.37),meeting the target in 100%of participants.Alkaline phosphatase levels were elevated at baseline in 8 participants[median 846 U/L(464)]and declined by 49%at week 48,representing a median decline of−364(244.5)U/L.PROMIS questionnaires showed trends toward improvements in all domains in children;adult scores showed no identifiable trends.Two children experienced transformational mobility gains,including advancement from full-time wheelchair use to independent ambulation.Lesion biopsies showed no changes in cellularity or composition,and 18F-NaF PET/CT scans showed no changes in tracer uptake,suggesting burosumab did not adversely impact lesional activity.Adverse events were mild,and none resulted in treatment withdrawal.Burosumab treatment in patients with FD was well-tolerated,restored phosphate homeostasis,and reduced alkaline phosphatase levels.Burosumab has the potential to lead to functional improvements and ambulation gains in severely affected patients and is a valuable tool to reduce the impact of FD-related disability. 展开更多
关键词 phase study hypophosphatemia phosphaturic hormone fibroblast growth factor fgf leading fibroblast growth factor fibrous dysplasia fd phosphate homeostasis burosumab
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