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Integrative clustering by colonic volatile fatty acids reveals microbiota and host physiological variation in weaned piglets 认领 引用
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作者 Chengcheng Li Stijn Heirbaut +5 位作者 Joris Michiels Yuhuang Hou Anneke Ovyn Noémie Van Noten Elout Van Liefferinge Jeroen Degroote 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第3期1554-1572,共19页
Background Volatile fatty acids(VFAs)reflect microbial fermentation linking gut microbiota,metabolism and host physiology.However,endogenous VFA profiles and their physiological relevance remain insufficiently charact... Background Volatile fatty acids(VFAs)reflect microbial fermentation linking gut microbiota,metabolism and host physiology.However,endogenous VFA profiles and their physiological relevance remain insufficiently characterized.This study aimed to identify distinct VFA phenotypes in weaned piglets and reveal how microbial fermentation patterns connect gut metabolism with animal health and performance.Results In this study,we integrated six independent trials comprising 164 weaned piglets.Here,k-means clustering of six VFAs in colonic digesta to identified two metabolite phenotypes:high level of short-chain fatty acids(HSCFA)and high level of branched-chain fatty acids(HBCFA).Generally,The HSCFA group exhibited significantly higher concentrations of VFA(P<0.001),and lower levels of ammonia and serum urea(P<0.001),consistent with enhanced carbohydrate fermentation and reduced nitrogen output.Additionally,the HSCFA group had significantly greater villus height in the distal small intestine(P<0.01),lower mid-colonic pH(P<0.001)and thrombocyte counts(P<0.01).In contrast,the HBCFA group showed elevated levels of branched-chain fatty acids and ammonia(P<0.001),as well as enrichment of Escherichia-Shigella,Rikenellaceae dgA-11 gut group and Prevotella(adjusted P<0.05).The HSCFA group was enriched in Lactobacillus,Mitsuokella and Dialister(adjusted P<0.05),and exhibited higher final body weight and average daily gain(P<0.05),indicating better growth performance.To explore associations between gut microbiota and VFA phenotypes,an XGBoost classification model was trained,based on genus-level composition,to predict the metabolic phenotype.It achieved a moderate accuracy and identified Unclassified Eubacterium coprostanoligenes group,Lactobacillus and Escherichia-Shigella as important genera contributing to group separation.Conclusions Clustering based on colonic VFA profiles identified distinct microbial and physiological patterns that may influence gut function and growth performance in weaned piglets.The enrichment of beneficial microbes and fermentation products in the HSCFA group suggests a more favorable intestinal environment,while protein fermentation in the colon seems associated with reduced animal performance and less beneficial intestinal environment. 展开更多
关键词 Branched-chain fatty acids Microbiota Short-chain fatty acids Weaned piglets
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Dietary intervention with Lycium barbarum polysaccharide and quinoa ultrafine powder ameliorates lipid metabolism in nonalcoholic fatty liver disease by regulating gut microbiota and activating AMPK/SREBP-1C/SCD-1 signaling 认领 引用 被引量：2
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作者 Hong Lin Wei Gong +4 位作者 Yuxin Zhao Junyu Lan Huimin Cui Na Li Jianjun Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期202-218,共17页
Changes in intestinal microecology play a crucial role in the pathogenesis and progression of metabolic diseases.Lycium barbarum polysaccharide(LBP)and quinoa ultrafine powder diet is a promising sources of prebiotics... Changes in intestinal microecology play a crucial role in the pathogenesis and progression of metabolic diseases.Lycium barbarum polysaccharide(LBP)and quinoa ultrafine powder diet is a promising sources of prebiotics.However,the potential synergistic effects of combining them as a microbiota-targeted dietary supplement to mitigate lipid accumulation in nonalcoholic fatty liver disease(NAFLD)remain unclear.Our study aims to provide evidence for the application foodutrient synergy interventions in NAFLD management,and also to support the clarification of these mechanisms.Following 12 weeks of a high-fat diet(HFD)-inducing NAFLD and an 11-week intervention in rats,the combination of LBP and quinoa ultrafine powder significantly decreased hepatocyte lipid accumulation and improved lipid metabolism disorders compared with those using either LBP or quinoa ultrafine powder alone.The combination increased beneficial intestinal microbiota,such as Lactobacillus acidophilus,Roseburia,Ruminococcus 2,and Prevotella,promoting the production of short-chain fatty acids,notably butyric acid,and then activated AMP-activated protein kinase/sterol regulatory element-binding protein 1C/stearoyl-CoA desaturase 1(AMPK/SREBP-1C/SCD-1)signaling.Combining LBP with quinoa ultrafine powder is a promising microbiota-targeted dietary supplement for ameliorating lipid disorders in NAFLD. 展开更多
关键词 Nonalcoholic fatty liver disease Lycium barbarum polysaccharide Quinoa Gut microbiota Short-chain fatty acid
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Black tea extract ameliorates fatty liver and fatty kidney in HFD-induced obese mice 认领 引用 被引量：1
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作者 Peng Ma Li Zhang +11 位作者 Zijing Wang Tianshu Xu Haiguang Yang Biyu Hou Yiwei Li Ping He Sin Man Lam Guanghou Shui Xiangyan Li Guanhua Du Jian Ying Guifen Qiang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1147-1167,共21页
Black tea is a kind of full-fermented tea with therapeutic potential for metabolic diseases.Ectopic lipid deposition(ELD)is an essential risk factor for organ injury in metabolic syndrome,especially in liver and kidne... Black tea is a kind of full-fermented tea with therapeutic potential for metabolic diseases.Ectopic lipid deposition(ELD)is an essential risk factor for organ injury in metabolic syndrome,especially in liver and kidney,for which effective interventions are lacking.Here,we explored whether black tea extract(BTE)improves fatty liver and fatty kidney,as well as identified the potential lipid biomarkers for ELD and lipid targets of BTE on the improvement of ELD.Transcriptome data from diet-induced obese mice were analyzed to confirm high-fat-diet feeding disturbs lipid metabolism in the liver and kidney.BTE prominently inhibited body weight gain,improved glucose metabolism,as well as reduced lipid droplet accumulation in the liver and kidney.Moreover,lipidomic profiling analyses identified 28 lipid classes in the liver while 29 in the kidney with that up-regulated glycerides and phosphatidylcholines,as well as down-regulated cardiolipin were the characteristic changes in ELD.BTE prominently reduced glycerides in ELD,thereby constituting the basis of its anti-ELD effect.Specifically,BTE displayed stronger effects on lowering cholesterol ester(CE)in fatty liver,while also affecting phospholipids and sphingolipids in fatty kidney.Ultimately,integrative analysis identified CE18:2 and triglyceride(TAG)56:4(20:2)as the potential lipid biomarkers for BTE in improvement of ELD.BTE could be an effective food supplement for the prevention and treatment of ELD.Notably,CE18:2 and TAG56:4(20:2),as the potential lipid biomarkers,may facilitate the research and development of anti-ELD drug. 展开更多
关键词 Black tea extract Ectopic lipid deposition Fatty liver Fatty kidney Lipidomics
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Metabolite-mediated crosstalk:unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens 认领 引用 被引量：1
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作者 Shaobo Zhang Xinghua Zhao +2 位作者 Xin He Wanyu Shi Ning Ma 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第2期655-674,共20页
Fatty liver hemorrhagic syndrome(FLHS)in laying hens is a metabolic disorder characterized by excessive hepatic lipid accumulation,inflammation,and hemorrhage,bearing pathological similarities to human non-alcoholic f... Fatty liver hemorrhagic syndrome(FLHS)in laying hens is a metabolic disorder characterized by excessive hepatic lipid accumulation,inflammation,and hemorrhage,bearing pathological similarities to human non-alcoholic fatty liver disease.With the rise of intensive poultry farming,the incidence of FLHS has markedly increased,resulting in significant economic losses in the poultry industry.The gut microbiota plays a crucial role in host digestion,metabolism,and immune regulation,particularly in liver diseases.Gut microbiota and its metabolites influence liver health via the gut-liver axis.This review aims to explore metabolite-mediated interactions between the laying hens and the gut microbiota,elucidating their role in the pathogenesis of FLHS.Host-derived metabolites,such as lipids,bile acids,amino acids,and carbohydrates,regulate the structure and function of the gut microbiota through the gut-liver axis,playing a role in FLHS progression.Concurrently,microbial metabolites,including short-chain fatty acids,bile acids,and amino acid derivatives,influence hepatic lipid metabolism,inflammation,and oxidative stress,driving the development of FLHS.Key microbes,such as Bacteroides,Lactobacillus,and Akkermansia muciniphila,are considered potential therapeutic targets due to their involvement in metabolite production.By integrating multi-omics data and mechanistic studies,this review highlights the central role of host–gut microbiota communication in FLHS and provides a theoretical basis and research direction for the development of microbiota-based intervention strategies. 展开更多
关键词 Fatty liver hemorrhagic syndrome Gut-liver axis Gut microbiota Metabolites Non-alcoholic fatty liver disease
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Lipid-related Insulin Resistance Indices for the Diagnosis of Non-alcoholic Fatty Liver Disease in Chinese Adults 认领 引用 被引量：1
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作者 Weihua Cao Yaqin Zhang +15 位作者 Ziyu Zhang Xinxin Li Wen Deng Shiyu Wang Xin Wei Linmei Yao Zixuan Gao Shuojie Wang Lu Zhang Yao Lu Ruyu Liu Shuling Wu Yuanjiao Gao Hongxiao Hao Yao Xie Minghui Li 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期171-182,共12页
Objective To analyze the diagnostic efficacy of lipid-related insulin resistance(IR)markers in patients with non-alcoholic fatty liver disease(NAFLD)and metabolic abnormalities(MA).Method Patients with NAFLD with MA,n... Objective To analyze the diagnostic efficacy of lipid-related insulin resistance(IR)markers in patients with non-alcoholic fatty liver disease(NAFLD)and metabolic abnormalities(MA).Method Patients with NAFLD with MA,non-NAFLD patients with MA,and patients with NAFLD without MA underwent liver biopsy.Homeostasis model assessment of insulin resistance(HOMA-IR),triglyceride/high-density lipoprotein cholesterol(TG/HDL-C),visceral obesity index(VAI),lipid accumulation product(LAP),and triglyceride glucose(TyG)index were analyzed.The diagnostic efficacy of these indicators of NAFLD was also evaluated.Results In the NAFLD-MA group,BMI,HOMA-IR,LAP,VAI,TyG index,and TG/HDL-C ratio were higher than those in the non-NAFLD-MA group(P<0.001).Logistic regression indicated that BMI and TyG index were independent risk factors for NAFLD.Receiver Operating Characteristic(ROC)curves analysis revealed that the Area Under the ROC Curve(AUC)for TyG-BMI was 0.819,and the optimal cutoff for NAFLD was TyG-BMI 39.77.For patients with NAFLD with or without MA,logistic regression analysis suggested that age,TG level,and TyG index were independent risk factors.The area under the ROC curve showed that AUC for the TyG index was 0.724.The optimal cutoff for NAFLD-non MA was a TyG index of 1.580.Conclusion TyG index has diagnostic value in both types of NAFLD;however,TyG-BMI is better in patients with NAFLD with MA and may be an effective screening indicator alone in patients with NAFLD without MA. 展开更多
关键词 Lipid-related insulin resistance marker Nonalcoholic fatty liver disease Triglyceride glucose index Metabolic abnormalities
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Schisandrin A ameliorates endoplasmic reticulum stress mediated apoptosis in metabolic associated fatty liver disease 认领 引用 被引量：1
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作者 Jing Zhou Ying Shi +8 位作者 Zuzhen Bao Mengmeng Luo Jie Li Marwan M.A.Rashed Suowen Xu Jianhua Yang Hong Duan Henggui Hu Kefeng Zhai 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2093-2103,共11页
Metabolic associated fatty liver disease(MAFLD)is closely linked to metabolic disorders and lack of effective therapeutic options.Schisandrin A(SA),derived from the traditional Chinese medicinal herb Schisandra,has sh... Metabolic associated fatty liver disease(MAFLD)is closely linked to metabolic disorders and lack of effective therapeutic options.Schisandrin A(SA),derived from the traditional Chinese medicinal herb Schisandra,has shown liver-protective properties.SA may counteract MAFLD by modulating endoplasmic reticulum stress(ERS)and inhibiting apoptosis.This study aimed to investigate the protective effects of SA on high-fat diet-induced MAFLD in C57BL/6 mice.The study also sought to elucidate the underlying mechanisms,focusing on the ERS signaling pathway and apoptosis.A MAFLD mouse model was established by feeding mice a high-fat diet.The mice were then randomly divided into the following groups:control,model,SA intervention(various dosages),atorvastatin-treated positive control,and ERS inhibitor combined with SA intervention.Serum lipid profiles,liver enzymes,and liver histopathology were assessed.Western blot,immunofluorescence(IF),and TUNEL assay were used to evaluate ERS and apoptosis-related protein expression.SA intervention markedly enhanced serum lipid profiles and reduced liver enzyme levels.The histopathological alterations observed in the model group were significantly mitigated by SA treatment.Western blot analysis revealed that SA effectively modulated the expression levels of proteins associated with ERS and apoptosis.Furthermore,IF and TUNEL assay results substantiated SA's regulatory influence on ERS and apoptotic pathways.SA effectively improved dyslipidemia and hepatic lipid metabolism abnormalities.It reduced hepatic lipid deposition and pathological damage in MAFLD mice induced by a high-fat diet.The mechanism of action may involve the regulation of the ERS signaling pathway,thereby protecting cells from apoptosis. 展开更多
关键词 Metabolic associated fatty liver disease Schisandrin A Endoplasmic reticulum stress Apoptosis
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Yinchen Wuling San ameliorates high-fat diet-induced metabolicassociated fatty liver disease in rats by remodeling the gut microbiota 认领 引用
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作者 Yi Zhang Jie Liu +8 位作者 Ai-Si Huang Yu-Fei Wang Jie Cao Mu-Lan Li Dan-Dan Shi Yi-Lin Hu Qin Deng Piao Long Bi-Chen Ai 《World Journal of Hepatology》 2026年第6期204-222,共19页
BACKGROUND Metabolic-associated fatty liver disease(MAFLD)is a common metabolic disorder characterized by hepatic steatosis,obesity,abnormal liver function,and dyslipidemia,with limited effective drug options availabl... BACKGROUND Metabolic-associated fatty liver disease(MAFLD)is a common metabolic disorder characterized by hepatic steatosis,obesity,abnormal liver function,and dyslipidemia,with limited effective drug options available.Increasing evidence links MAFLD to dysbiosis of the gut microbiota and microbial metabolites,including short-chain fatty acids(SCFAs).We hypothesized that Yinchen Wuling San(YCWLS)mitigates MAFLD by remodeling gut microbiota and associated SCFAs profiles.AIM To determine whether YCWLS alleviates MAFLD by inducing gut microbiota remodeling in rats.METHODS A high-fat diet was used to induce MAFLD in rats.The animals were assigned to control,model,positive drug(Bifidobacterium quadruple live bacteria tablets,2.1 g/kg),and YCWLS(6.38 g/kg)groups and treated for 4 weeks.Liver and adipose histopathology was evaluated using hematoxylin-eosin staining.Serum lipids and liver enzymes were measured,gut microbiota was profiled by 16S rRNA sequencing,and fecal SCFAs were quantified using gas chromatography-mass spectrometry.RESULTS Compared to the model group,YCWLS reduced the liver index and improved liver injury markers,specifically alanine aminotransferase and aspartate aminotransferase(alanine aminotransferase model 50.05±8.98 vs YCWLS 22.97±2.40 P<0.01;aspartate aminotransferase model 217.32±13.70 vs YCWLS 122.65±6.49 P<0.01),alleviating hepatic steatosis and tissue injury.YCWLS also decreased serum triglycerides,total cholesterol,and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol(triglycerides model 1.26±0.18 vs YCWLS 0.61±0.09 P<0.01;total cholesterol model 2.83±0.30 vs YCWLS 1.79±0.09 P<0.01;low-density lipoprotein cholesterol model 0.49±0.16 vs YCWLS 0.17±0.02 P<0.01;high-density lipoprotein cholesterol model 0.50±0.11 vs YCWLS 1.01±0.09 P<0.01).Microbiota analysis revealed a reduction in Firmicutes-related taxa(including Ruminococcaceae and Clostridiales)and an increase in Verrucomicrobia,Lachnospiraceae,Peptostreptococcaceae,and Akkermansia.Most fecal SCFAs exhibited modest,non-significant increases;however,butyrate displayed a near-significant upward trend(P=0.052).CONCLUSION Yinchen Wuling San improves liver injury and dyslipidemia in MAFLD rats and is associated with the enrichment of Akkermansia and Lachnospiraceae,supporting a gut microbiota-linked mechanism. 展开更多
关键词 Metabolic-associated fatty liver disease Yinchen Wuling San Gut microbiota Short-chain fatty acids Gut-liver axis
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Metabolically associated fatty liver disease: What hepatologists need to know about this systemic disease 认领 引用
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作者 Alexander Plakida Olga Iushkovska Lidia Elżbieta Sierpińska 《World Journal of Hepatology》 2026年第3期12-47,共36页
Metabolically associated fatty liver disease,recently redefined from non-alcoholic fatty liver disease,has emerged as the most common chronic liver disease worldwide.The new nomenclature emphasizes the metabolic drive... Metabolically associated fatty liver disease,recently redefined from non-alcoholic fatty liver disease,has emerged as the most common chronic liver disease worldwide.The new nomenclature emphasizes the metabolic drivers and highlights its strong links to extrahepatic disorders such as diabetes,cardiovascular disease,and chronic kidney disease.Yet,controversies remain regarding terminology,diagnostic thresholds,and the lack of effective disease-modifying drugs.This review discusses the rationale for the new definition,summarizes current knowledge of pathogenesis and the clinical spectrum,and highlights critical research gaps,including the role of gut microbiota,the need for improved risk stratification,and the evaluation of novel therapeutic classes. 展开更多
关键词 Metabolic associated fatty liver disease Non-alcoholic fatty liver disease Metabolic dysfunction-associated steatotic liver disease Metabolic associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Diabetes mellitus Viral hepatitis Hepatocarcinoma
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n-3 Polyunsaturated fatty acids substitution for saturated fatty acids in diet ameliorates age-related cognitive decline via ABCA1/ApoE-mediated lipid efflux 认领 引用
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作者 Xin Zhang Tianzhi Xie +8 位作者 Kemin Guo Xinran Liu Shuang Zhou Tian Yuan Yongbo She Rui Guo Jun Hu Xuebo Liu Zhigang Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第6期2821-2832,共12页
Dietary lipids are essential for brain health.However,high-fat diets(HFD)have produced conflicting results in studies on aging brain health,likely due to variations in fatty acid composition.While aging-related glial ... Dietary lipids are essential for brain health.However,high-fat diets(HFD)have produced conflicting results in studies on aging brain health,likely due to variations in fatty acid composition.While aging-related glial lipid accumulation is exacerbated by saturated fatty acids(SFAs)-rich HFD,it remains unclear whether replacing SFAs with n-3 polyunsaturated fatty acids(PUFAs)can mitigate this effect and the associated neuroinflammation.This study investigates the effects of SFAs-rich and n-3 PUFAs-rich HFDs in 18-monthold C57BL/6J mice over a 12-week period.Mice fed the SFAs-rich HFD showed increased body weight,elevated glucose and lipid levels,and lipid accumulation in glial cells.Behavioral tests,including novel object recognition and the Barnes maze,revealed significant cognitive impairments in these mice.In contrast,the n-3PUFAs-rich HFD increased brain docosahexaenoic acid levels,activated the ATP-binding cassette transporter Al/apolipoprotein E pathway,reduced lipid accumulation in glial cells,and ultimately reversed cognitive decline.Consistent with these findings,the n-3 PUFAs-rich diet also attenuated inflammatory markers such as tumor necrosis factorαand interleukin 1β,and decreased oxidative stress markers including malondialdehyde and oxidized glutathioneeduced glutathione.These findings provide novel insights into the role of fatty acid composition in HFD affecting aged brain health,offering strong evidence for the neuroprotective benefits of n-3 PUFAs-enriched diets. 展开更多
关键词 Age-related cognitive decline Saturated fatty acids Lipid accumulation n-3 Polyunsaturated fatty acids
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ACSL4 is a target forβ-hydroxybutyrate-induced increase in fatty acid content and lipid droplet accumulation in bovine mammary epithelial cells 认领 引用
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作者 Ming Li Jingjing Wang +8 位作者 Jia’nan Wen Juan JLoor Qianming Jiang Jingyi Wang Huijing Zhang Yue Yang Wei Yang Bingbing Zhang Chuang Xu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第3期1137-1149,共13页
Ketosis,a common metabolic disease during early lactation,is associated with high circulating levels ofβ-hydroxybutyrate(BHB).A portion of BHB that reaches the mammary gland is utilized as precursor for synthesis of ... Ketosis,a common metabolic disease during early lactation,is associated with high circulating levels ofβ-hydroxybutyrate(BHB).A portion of BHB that reaches the mammary gland is utilized as precursor for synthesis of fatty acids.Recent findings from nonruminant studies revealed that long chain fatty acyl-CoA ligase 4(ACSL4)could play a role in the regulation of cellular fatty acid metabolism,but the mechanisms by which ACSL4 mediates cellular lipid metabolism in response to BHB remains unclear.To achieve the aims,we conducted in vivo or in vitro analyses using bovine mammary gland biopsies and the immortalized mammary epithelial cell line(MAC-T).The in vivo study(n=6 cows per group)involved healthy cows(plasma BHB2.0 mmol L–1)from which mammary gland tissue was biopsied.In vitro,MAC-T cells were challenged with 0,0.3,0.6,1.2,or 2.4 mmol L–1BHB for 24 h to determine an optimal dose.Subsequently,MAC-T were incubated with 1.2 mmol L–1BHB for 0,3,6,12,24,or 48 h.Furthermore,MAC-T cells were treated with small interfering ACSL4(siACSL4)for 24 h or ACSL4 overexpression plasmid(pcACSL4)for 36 h followed by a challenge with 1.2 mmol L–1BHB for 24 h.Results showed that increased mRNA and protein abundance of lipogenic genes were linked to both mammary gland and in vitro challenge with BHB.BHB increased fatty acid content by activating ACSL4 expression,whereas inhibition of ACSL4 reduced BHB-induced reactive oxygen species(ROS)overproduction,enhancement of mitochondrial membrane potential,increase in fatty acid content,and lipid droplet accumulation.Furthermore,we also elevated ACSL4 expression with an overexpression plasmid to clarify its molecular role in response to BHB challenge.ACSL4 overexpression enhances BHB-induced lipid droplet accumulation by increased fatty acid content.Overall,the information showed that ACSL4 is crucial for the process of producing fatty acids from exogenous BHB.Reduced ACSL4 decreased fatty acid content and lipid droplet accumulation,improved mitochondrial function,directed more fatty acids towards oxidation.Thus,ACSL4 plays an important role in determining the fate of intracellular fatty acids and BHB in BMECs. 展开更多
关键词 bovine mammary epithelial cells fatty acid content ketosis BHB ACSL4
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Prolonged consumption of white beer increases levels of short-chain fatty acids and Prevotellaceae bacteria in mice 认领 引用
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作者 Zhaoxi Liu Yongheng Rong +5 位作者 Shuxia Huang Hua Yin Lushan Wang Shumin Hu Junhong Yu Min Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期67-79,共13页
Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as... Beer is a prominent fermented food product and is regarded as the one of most widely consumed beverage globally.There is a dearth of studies examining the impact of different types of beer with intricate components as a comprehensive intervention on human health and immune status.This study used a 14-day continuous drinking intervention consisting of 5 beers,namely white beer,India pale ale(IPA),Pilsner,non-alcoholic beer,and premium lager beer.Surprisingly,our findings indicate that consuming white beer has little impact on the gut microbiota and physiological condition of mice,whereas consuming other types of beer leads to an increase in Lactobacillus and a decrease in Lachnospiraceae.In addition,we devised an extended feeding experiment to investigate the comparative safety and health benefits of consuming white beer.The research showed that when mice drank excessive quantities of white beer over 42 days,the intestines of the mice had more Prevotellaceae and the Firmicutes to Bacteroidetes ratio(F/B ratio)had a decline from 1.29 to 0.38.The levels of acetic acid,propionic acid,and isobutyric acid increased from 1.0,0.27,and 0.015 mg/g to 1.28,0.38,and 0.037 mg/g,respectively(P<0.05).There were no significant changes observed in the levels of most measured cytokines in the colon tissue of mice that consumed beer,however,there was an increase in the concentration of the inflammatory factor tumor nesrosis factor-α(TNF-α)from 135.86 pg/mL in the control group to 189.78 pg/mL in the white beer group(P<0.01).These results give us real-world proof that we can use to study how different beers affect the host’s health and satisfaction in future research. 展开更多
关键词 Gut microbiota Beer Cytokine Short-chain fatty acids White beer Prevotellaceae
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Obakulactone Alleviates Rheumatoid Arthritis by Promotion of ACOT1 Degradation via the Ubiquitin‒Proteasome Pathway and Restoration of Unsaturated Fatty Acid Homeostasis 认领 引用
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作者 Hongda Liu Le Yang +12 位作者 Yu Yang Huan Tang Junling Ren Hui Sun Xin Sun Songyuan Tang Chong Qiu Ye Sun Jigang Wang Guangli Yan Ling Kong Ying Han Xijun Wang 《Engineering》 SCIE EI CSCD 2026年第1期341-360,共20页
Rheumatoid arthritis(RA)remains a therapeutic challenge because of the suboptimal efficacy and significant adverse effects of current treatments.Obakulactone(OL),a natural tetracyclic triterpenoid isolated from Phello... Rheumatoid arthritis(RA)remains a therapeutic challenge because of the suboptimal efficacy and significant adverse effects of current treatments.Obakulactone(OL),a natural tetracyclic triterpenoid isolated from Phellodendri cortex,has emerged as a promising candidate for RA intervention.However,its underlying mechanism remains poorly understood.In this study,we investigated the therapeutic effects of OL and its molecular mechanisms in RA using a multifaceted approach.A complete Freund's adjuvant(CFA)-induced RA rat model revealed that OL significantly alleviated joint swelling and restored the expression of CD3+T cells and CD68+macrophages in joints,and the polarization state of macrophages shifted from proinflammatory M1(CD86)to anti-inflammatory M2(CD206)dominant.In addition,OL alleviated pathological changes in lymphoid organs(thymus and spleen),effectively inhibited the differentiation of CD4+T cells into T helper 17(Th17)cells,and normalized serum levels of inflammatory cytokines(e.g.,interleukin(IL)-6 and tumor necrosis factor-α(TNF-α))and RA diagnostic markers(e.g.,creactive protein(CRP)and rheumatoid factor(RF)).Multiomics profiling revealed that OL corrected the dysregulated biosynthesis and metabolism of unsaturated fatty acids(e.g.,arachidonic acid and linolenic acid)in RA rats,with acyl coenzyme A(CoA)thioesterase 1(ACOT1)identified as a critical regulator.In vitro studies have shown that OL significantly inhibits cell proliferation and inflammatory cytokine secretion and promotes the apoptosis of RA synovial fibroblasts(SFs).It inhibited the M1 polarization of Raw264.7 macrophages and promoted M2 polarization.Mechanistically,cellular thermal shift assays(CETSA),microscale thermo phoresis(MST),surface plasmon resonance(SPR),and short hairpin RNA(shRNA)experiments revealed ACOT1 as the direct target of OL.OL enhanced ACOT1 ubiquitinationmediated proteasomal degradation,thereby reducing downstream stearoyl-CoA desaturase-1 expression and inhibiting the Janus kinase(JAK)-signal transducer and activator of transcription(STAT)and phosphoinositide 3-kinase(PI3K)-protein kinase B(AKT)signaling pathways,thus suppressing inflammation and fibrosis in SFs.This study establishes OL as a potential RA therapeutic agent and highlights ACOT1 as a novel target for RA intervention,offering insights into fatty acid metabolism reprogramming as a therapeutic strategy. 展开更多
关键词 Obakulactone Rheumatoid arthritis Unsaturated fatty acids Acyl coenzyme A thioesterase 1 Synovial fibroblasts Multiomics Ubiquitin-proteasome pathway
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Inheritance and QTL mapping identify multi-effect loci for fatty acid related traits in peanut(Arachis hypogaea L.) 认领 引用
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作者 Guanghao Wang Hui Wang +7 位作者 Liangqiong He Zhuqiang Han Jiaowen Pan Huan Zhang Lei Hou Xingjun Wang Baozhu Guo Chuanzhi Zhao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第6期2329-2340,共12页
Peanut(Arachis hypogaea L.)is an important oil and edible protein crop.Its fatty acid composition not only infiuences the quality of peanut oil but also impacts fiavor,shelf life,and consumer health.Peanut oil is comp... Peanut(Arachis hypogaea L.)is an important oil and edible protein crop.Its fatty acid composition not only infiuences the quality of peanut oil but also impacts fiavor,shelf life,and consumer health.Peanut oil is comprised of approximately 80%oleic acid(C18:1)and linoleic acid(C18:2),10%palmitic acid(C16:0),and the remaining 10%includes stearic acid(C18:0),arachidic acid(C20:0),gadoleic acid(C20:1),behenic acid(C22:0),and lignoceric acid(C24:0).To unravel the genetic foundation of fatty acid content and delve into QTL localization,high-density SNP microarrays were used to genotype the RIL population of‘Sun Oleic 97R'בNC94022'.A genetic linkage map was constructed with 3,141 SNP markers,covering a total genetic distance of 3,051.81 c M.Sixty quantitative trait loci(QTLs)associated with fatty acids were distributed in 11 linkage groups,with phenotypic variance explained(PVE)ranging from 1.37 to 44.92%.Notably,the QTLs q FAT_A05.1 and q FAT_A08.1 are multiple-effect loci contributing to various fatty acid compositions.Moreover,15 haplotypes for the QTLs q FAT_A05.1 and q FAT_A08.1 were identified through genotyping 178 peanut germplasms.Haplotype analysis in a natural population confirmed the close relationship of the QTLs with the contents of oil,oleic acid,lignoceric acid,palmitic acid and behenic acid.This study serves as a valuable reference for selecting improved peanut genotypes with superior oil quality and desirable fatty acid composition. 展开更多
关键词 peanut fatty acid QTL genetic map
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Tuning biochar surface area for optimal chain elongation:a strategy for high-efficiency medium-chain fatty acids production 认领 引用
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作者 Yuhao Liu Lei Zhao +7 位作者 Haiping Gu Xinyi Wang Bingjie Wang Kui Wang Wei Huang Han Yang Jingjing Zhang Junjiao Zhang 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第2期127-142,共16页
This study used ethanol and acetate as substrates,anaerobic digestion sludge as inoculum,and selected bamboo charcoal with three particle size conditions(<25,45–75,100–250μm)as the mediating material.While maint... This study used ethanol and acetate as substrates,anaerobic digestion sludge as inoculum,and selected bamboo charcoal with three particle size conditions(<25,45–75,100–250μm)as the mediating material.While maintaining consistent electrical conductivity levels of bamboo charcoal,we investigated the effect of specific surface area on the chain elongation reactions.Experimental results demonstrated that when bamboo charcoal served as the mediating material,larger specific surface area significantly enhanced the chain elongation for the production of medium-chain fatty acids.Microbial community composition analysis via 16S rRNA sequencing demonstrated that bamboo charcoal intervention promoted the enrichment of Clostridium_sensu_stricto_12,a keystone functional microbe exhibiting statistically significant positive correlations with the yield,electron transfer efficiency,and selectivity of MCFAs.Metagenomic analysis identified the simultaneous presence of reverseβ-oxidation and fatty acid biosynthesis pathways,with reverseβ-oxidation pathway serving as the dominant route.Notably,the Candidatus_Microthrix genus exhibited dual functionality by engaging in both pathways for MCFAs production. 展开更多
关键词 Chain elongation Bamboo biochar Specific surface area Medium-chain fatty acids Reverseβ-oxidation pathway
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Recent advances in the analysis of unsaturated fatty acids in biological samples based on chemical derivatization and mass spectrometry techniques 认领 引用
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作者 Yuanyuan Lin Ningbo Chen +5 位作者 Wenda Chen Fan Yin Ling Yang Xuan Chen Jian-Liang Zhou Tian Xie 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第3期692-707,共16页
Fatty acids(FAs)play a vital role in various physiological processes in the human body,and the analysis of FA isomers is of utmost importance in the research of various diseases and FA metabolic pathways.Over the last... Fatty acids(FAs)play a vital role in various physiological processes in the human body,and the analysis of FA isomers is of utmost importance in the research of various diseases and FA metabolic pathways.Over the last few years,the use of chemical derivatization methods to alter the composition of FAs has been found to be highly effective in overcoming the drawback of poor sensitivity in mass spectrometry(MS)analysis due to the poor ionizability of functional groups in FA molecules.Furthermore,certain chemical derivatization methods have enabled detection of C=C and differentiation of cis-trans isomers.As a result,the development and use of chemical derivatization-based MS to analyze FAs has gained significant interest.This review highlights technological innovations in the development of MS detection methods for unsaturated FAs(UFAs)based on chemical derivatization.Special emphasis is placed on two significant strategies:carboxyl group derivatization and C=C derivatization.In addition,it focuses on applications in various fields,discusses persistent challenges,and explores potential future directions.This review aims to provide a perspective on the advanced design and development of MS detection methods of FAs based on chemical derivatization. 展开更多
关键词 Fatty acids Chemical derivatization Unsaturated C=C bonds Carboxyl group Mass spectrometry
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Decoding Links between Gut Microbiota and Metabolic-associated Fatty Liver Disease:Metaanalysis and Mediation Study Uncover Speciesspecific Taxa and a Novel Bile Acid Mediator 认领 引用
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作者 Xinghao Yi Haoxue Zhu +2 位作者 Mengyu He Shan Gao Ming Li 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期202-214,共13页
Objective Previous Mendelian randomization(MR)studies have suggested an association between the gut microbiome and metabolic-associated fatty liver disease(MAFLD).However,the reliance on 16S rRNA sequencing data has l... Objective Previous Mendelian randomization(MR)studies have suggested an association between the gut microbiome and metabolic-associated fatty liver disease(MAFLD).However,the reliance on 16S rRNA sequencing data has led to inconsistent findings and limited species-level insights.To address this,we conducted a de novo MR analysis using species-level shotgun metagenomic data,combined it with a meta-analysis to consolidate the existing evidence,and explored metabolite-mediated pathways.Methods Bidirectional MR analyses were performed between 883 gut microbiota taxa(derived from shotgun metagenomic genome-wide association study)and MAFLD.Published MR studies(up to December 1,2024)were identified using PubMed,Embase,Web of Science,and the Cochrane Library for meta-analysis.Multivariable MR(MVMR)and mediation analyses were applied to assess the mediating effects of 1,400 blood metabolites.Results The de novo MR identified 25 MAFLD-associated microbial taxa.Integration with 7 published studies revealed 34 causal taxa,including 10 at the species level.Among the 1,400 metabolites,53 showed causal links with MAFLD.MVMR and mediation analyses identified deoxycholate as a mediator of the effect of Bifidobacterium on MAFLD risk(22.06%mediation proportion).Conclusion This study elucidated the connections between species-level gut microbiota and MAFLD,highlighting the interplay between microbiota,metabolites,and disease pathogenesis.These findings provide novel insights into the potential therapeutic targets for MAFLD. 展开更多
关键词 Gut microbiome Metabolic-associated fatty liver disease Causal associations Mendelian randomization Meta-analysis
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Gut microbiota-mediated short-chain fatty acids contribute to the protective effects of Xiaoxuming decoction(小续命汤)against lipopolysaccharide-induced acute lung injury 认领 引用
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作者 XIANG Yijin YANG Zhigang +2 位作者 GONG Shaomin LI Xiangting CAI Min 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第2期285-293,共9页
OBJECTIVE:To investigate the mechanisms underlying the protective effects of Xiaoxuming decoction(小续命汤,XXMD)against lipopolysaccharide(LPS)-induced acute lung injury(ALI).METHODS:LPS was used to construct an ALI m... OBJECTIVE:To investigate the mechanisms underlying the protective effects of Xiaoxuming decoction(小续命汤,XXMD)against lipopolysaccharide(LPS)-induced acute lung injury(ALI).METHODS:LPS was used to construct an ALI model in mice and human pulmonary alveolar epithelial cells(HPAEpiCs).Acetate and acetate-producing bacteria,including Blautia hydrotrophica,Bacteroides thetaiotaomicron,Akkermansia muciniphila,and Bacteroides vulgatus,were detected after XXMD treatment.Zonula occludens-1(ZO-1),occludin,phosphorylated nuclear factor-kappa B p65(p-NF-κBp65),and NF-κBp65 levels were measured by Western blotting,and an enzyme-linked immunosorbent assay was performed to detect tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),and IL-6 secretion.Transepithelial electrical resistance,fluorescein isothiocyanate-dextran,and cell counting kit-8 assays were used to detect the cell's monolayer integrity,permeability,and viability.RESULTS:XXMD alleviated the LPS-induced downregulation of acetate and acetate-producing bacteria in feces.Furthermore,XXMD suppressed the LPS-induced downregulation of ZO-1 and occludin expression in lung tissues,LPS-induced upregulation of TNF-α,IL-1β,and IL-6 in bronchoalveolar lavage fluid,and p-NF-κBp65 levels in lung tissues.Acetate had similar effects in LPS-induced mice.Meanwhile,the seven-day survival probability was improved by XXMD or acetate treatment.Furthermore,acetate could alleviate LPS-mediated cell viability,inflammation,and permeability in HPAEpiCs,while acetate-induced effects could be abrogated by GLPG0974,a short-chain fatty acid(SCFA)receptor G-protein coupled receptor 43 antagonist.CONCLUSION:XXMD's therapeutic effect may be related to gut microbiota-mediated SCFAs,which alleviated LPS-induced ALI. 展开更多
关键词 acute lung injury short-chain fatty acids permeability Xiaoxuming decoction
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The flotation separation of fluorite and calcite particles facilitated by a novel fatty acid-based surfactant 认领 引用
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作者 LIU Peng TIAN Yu-hui +1 位作者 TIAN Meng-jie SUN Wei 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第3期1188-1202,共15页
Oleic acid is a commonly used fatty acid collector in fluorite flotation,known for its effective collecting performance and cost-effectiveness,but with a limited selectivity.In this study,a novel collector,α-sulfonat... Oleic acid is a commonly used fatty acid collector in fluorite flotation,known for its effective collecting performance and cost-effectiveness,but with a limited selectivity.In this study,a novel collector,α-sulfonate group mixed acid(α-SMA),is introduced.The flotation test results demonstrate that the α-SMA collector provides significantly better selectivity in fluorite flotation.Specifically,the α-SMA collector exhibits a similar collecting ability to oleic acid for fluorite;however,its capacity to collect calcite is substantially lower.Zeta potential tests indicate that,under identical dosage conditions,α-SMA adsorbs in greater quantities on fluorite than on calcite.As a result,fluorite exhibits substantially higher flotation recoveries versus calcite with α-SMA collector.X-ray photoelectron spectroscopic analysis suggests that α-SMA facilitates a higher electron donation to Ca2+ions on fluorite compared to calcite surface,forming stronger chemical bonds with fluorite surface.This enhanced interaction leads to stronger adsorption of α-SMA on fluorite.Furthermore,when α-SMA adsorbs solely through its sulfonic group,its carbon chain is positioned almost parallel to calcite surface.This configuration significantly reduces the hydrophobicity of the calcite surface,leading to very low calcite recovery rates with α-SMA collector. 展开更多
关键词 fluorite flotation collector oleic acid fatty acid α-sulfonate group
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Crosstalk between non-alcoholic fatty pancreas disease and metabolic dysfunction-associated steatotic liver disease:Immunometabolic interactions and clinical implications 认领 引用
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作者 Stanislav Kotlyarov 《World Journal of Gastroenterology》 SCIE CAS 2026年第15期1-8,共8页
Non-alcoholic fatty pancreas disease(NAFPD)is a recognized but insufficiently studied clinical disease.The clinical and pathophysiological links between NAFPD and other metabolic diseases,such as metabolic dysfunction... Non-alcoholic fatty pancreas disease(NAFPD)is a recognized but insufficiently studied clinical disease.The clinical and pathophysiological links between NAFPD and other metabolic diseases,such as metabolic dysfunction-associated steatotic liver disease(MASLD),are still largely unknown.Both conditions are considered to be manifestations of systemic metabolic syndrome,which indicates common developmental pathways.Although NAFPD and MASLD are closely related through common immunometabolic pathways,they also have differences that are reflected in clinical observations.A recent study by Heymann et al published in World Journal of Gastroenterology showed no direct correlation between the degree of pancreatic steatosis and the severity of steatohepatitis or liver fibrosis,indicating a need for further study of the complex immunometabolic interactions that mediate the relationship between these organs. 展开更多
关键词 Non-alcoholic fatty pancreas disease Metabolic dysfunction-associated steatotic liver disease Obesity Steatosis Fatty degeneration Lipids Triglycerides
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Size and light scattering enhancement of sea spray aerosol via condensing fatty acid vapor 认领 引用
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作者 Minglan Xu Narcisse Tsona Tchinda +1 位作者 Siyang Li Lin Du 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期693-702,共10页
Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were perfor... Once sea spray aerosol(SSA)particles are emitted into the atmosphere,they tend to interact with organic compounds and form a certain amount of organic coating on their surfaces.Here,laboratory measurements were performed to investigate property changes between uncoated and coated SSA particles to assess the effect of organic coating on the surface chemistry and optical properties of nascent SSA.Stearic acid,oleic acid and mixed fatty acid were used as a proxy for coating materials and applied to aerosols produced by SSA generator.We found that the geometric mean diameter of SSA particles increased with increasing concentration of the fatty acid vapor due to higher heating temperatures,suggesting the formation of thicker coatings.Characterization by Fourier transform infrared spectroscopy and transmission electron microscope demonstrated that the SSA surface was coated with an organic coating of fatty acids,which gave the SSA a core–shell morphology.Furthermore,optical measurements by photo-acoustic extinctiometer at 375 nm revealed significantly enhanced light scattering efficiency and complex refractive index from fatty acid-coated SSA particles.The current results suggest that the fatty acid coating changes the diameter and surface composition of SSA particles,which may further impact their optical properties.It is therefore necessary to accurately characterize the overall properties of SSA particles carrying organic coatings due to condensing fatty acid vapor to reveal their overall impact on climate. 展开更多
关键词 Sea spray aerosol Organic coating Fatty acid Light scattering Complex refractive index
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