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Systematic acupuncture explains acupuncture at Baihui(GV20)and Fengchi(GB20)targeting the inflammatory response to regulate migraine 认领 引用
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作者 MIN Yu ZHENG Meifeng +3 位作者 SUN Ju PENG Zetong CAO Zhixian HUANG Xiaohua 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第3期610-617,共8页
OBJECTIVE:To take Baihui(GV20)and Fengchi(GB20)targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating acupoints.METHODS:The target informa... OBJECTIVE:To take Baihui(GV20)and Fengchi(GB20)targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating acupoints.METHODS:The target information of Baihui(GV20)and Fengchi(GB20)was retrieved,and after intersection with migraine,Kyoto Encyclopedia of Genes and Genomes(KEGG),Reactome,and Uni Prot Keywords were used for functional enrichment.After selecting the main pathway,rats were selected and nitroglycerin was used for modeling,and the behavioral scores,inflammatory factors,heme oxygenase 1(HMOX1),protein kinase B(AKT1),signal transducer and activator of transcription 3(STAT3),phosphorylated extracellular signal-regulated kinase 1/2(P-ERK1/ERK2)and other states of the rats in the acupuncture,twisting,and electroacupuncture groups were compared.RESULTS:A total of 135 Baihui(GV20)targets and 27 Fengchi(GB20)targets were collected.A total of 73 target information were obtained after the intersection of these targets in migraine.These 73 targets have three main pathways:hypoxia-inducible factor 1(HIF-1)signaling pathway,signaling by interleukins and inflammatory response.The main targets in the pathway were verified and found that interleukin-1 beta(IL-1β),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)and HMOX1,AKT1,STAT3,P-ERK1/ERK2 can be regulated by Baihui(GV20)and Fengchi(GB20).CONCLUSION:Baihui(GV20)and Fengchi(GB20)can regulate migraine by regulating inflammatory factors and HMOX1,AKT1,STAT3,P-ERK1/ERK2 and other changes in HIF-1 signaling pathway,Signaling by Interleukins and Inflammatory response pathways.Based on systems biology and network pharmacology,and with the model of"acupoint-target-disease",explore the research methods of systematic acupuncture and moxibustion.We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation. 展开更多
关键词 Baihui(GV20) Fengchi(GB20) inflammation migraine disorders acupuncture systematic acupuncture
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Electroacupuncture at Fengchi(GB20) inhibits calcitonin gene-related peptide expression in the trigeminovascular system of a rat model of migraine 认领 引用 被引量：14
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作者 Luo-peng Zhao Lu Liu +3 位作者 Pei Pei Zheng-yang Qu Yu-pu Zhu Lin-peng Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第5期804-811,共8页
Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide（CGRP） plays an important role in the pathophysiology of migraine, and it is the... Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide（CGRP） plays an important role in the pathophysiology of migraine, and it is therefore, a potential therapeutic target for treating the pain. In the present study, a rat model of conscious migraine, induced by repeated electrical stimulation of the superior sagittal sinus, was established and treated with electroacupuncture at Fengchi（GB20）（depth of 2–3 mm, frequency of 2/15 Hz, intensity of 0.5–1.0 m A, 15 minutes/day, for 7 consecutive days）. Electroacupuncture at GB20 significantly alleviated the decrease in hind paw and facial withdrawal thresholds and significantly lessened the increase in the levels of CGRP in the trigeminal ganglion, trigeminal nucleus caudalis and ventroposterior medial thalamic nucleus in rats with migraine. No CGRP-positive cells were detected in the trigeminal nucleus caudalis or ventroposterior medial thalamic nucleus by immunofluorescence. Our findings suggest that electroacupuncture treatment ameliorates migraine pain and associated cutaneous allodynia by modulating the trigeminovascular system ascending pathway, at least in part by inhibiting CGRP expression in the trigeminal ganglion. 展开更多
关键词 nerve regeneration electroacupuncture migraine calcitonin gene-related peptide cutaneous allodynia anti-nociceptive Fengchi trigeminal ganglion neural regeneration
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Effect of acupuncture at Fengchi(GB 20)on the activity of myosin light chain kinase in the middle meningeal artery of migraine modeled rats 认领 引用 被引量：6
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作者 Zhou Peijuan Wang Aicheng +2 位作者 Li Bai Liu Chunyan Wang Yu 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2015年第3期301-305,共5页
OBJECTIVE:To study the effect of acupuncture at Fengchi(GB 20) on the activation of myosin light chain kinase(MLCK) in the middle meningeal artery of migraine modeled rats.METHODS:Forty-four clean grade healthy female... OBJECTIVE:To study the effect of acupuncture at Fengchi(GB 20) on the activation of myosin light chain kinase(MLCK) in the middle meningeal artery of migraine modeled rats.METHODS:Forty-four clean grade healthy female Sprague-Dawley(SD) rats were randomly divided into four groups:the control group,blank control group,Fengchi(GB 20) acupuncture group,and Fengchi(GB 20) prevention group.Neurogenic inflammation of these rats was induced by electrical stimulation.The γ-32P infiltration method was then used to detect MLCK activation in the middle meningeal artery,and immunocytochemistry was applied to detect the structural protein expression of MLCK.RESULTS:The migraine model was successfully established in the rats.Compared with the control group,MLCK activation was significantly decreased in the blank control group(P < 0.01).CONCLUSION:The activation of MLCK in the middle meningeal artery was increased by acupuncture at Fengchi(GB 20),indicating its effectiveness in preventing and curing on acute migraine attacks. 展开更多
关键词 Myosin-light-chain kinase,Point GB 20（Fengchi） Migraine disorders,Middle meningeal artery
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EFFECT OF ACUPUNCTURE OF FENGCHI (GB 20) ON BLOOD PRESSURE AND SERUM IL-6 and PLASMA ET LEVELS IN PATIENTS WITH HYPERTENSION 认领 引用
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作者 陈邦国 钱春艳 +1 位作者 瞿涛 毛红蓉 《World Journal of Acupuncture-Moxibustion》 CAS 2006年第1期10-14,共5页
Objective：To observe the effect of acupuncture of Fengchi （风池 GB 20） on blood pressure, serum IL-6 and plasma endothelin （ET） contents in patients with hypertension. Methods： Thirty cases of hy-pertension pati... Objective：To observe the effect of acupuncture of Fengchi （风池 GB 20） on blood pressure, serum IL-6 and plasma endothelin （ET） contents in patients with hypertension. Methods： Thirty cases of hy-pertension patients were made up of treatment group and treated with acupuncture of Fengchi （GB 20） ; while 20 healthy subjects were made up of control group. Blood pressure was determined before and after the treatment. Fasting blood samples were taken from the cubital venous vessel for detecting serum interleukin （IL）-6 and plasma ET contents with radioimmunoassay before and after acupuncture treatment. Results： Before the treatment, in hypertension patients, serum IL-6 and plasma ET levels were significant higher thanthose in healthy subjects （P〈 0.01 ）; while after the treatment, blood pressure of treatment group declined significantly （ P 〈 0.01 ）, serum IL-6 and plasma ET levels decreased considerably （ P 〈 0.01 ）. Conclusion： Acupuncture of Fengchi （GB 20） can lower blood pressure, regulate cellular immunity and secretion functions of the vascular endothelial cells in hypertension patients. 展开更多
关键词 Hypertension Acupuncture therapy Fengchi （GB 20） Serum interleukin-6 Endothelin
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CLINICAL APPLICATION OF FENGCHI(GB 20) 认领 引用
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作者 单宝枝 邵水金 《World Journal of Acupuncture-Moxibustion》 CAS 1999年第3期29-32,共4页
The article introduces the writers’ experience in using Fengchi(GB 20) to treat sciatica,gastric ulcer and bronchial asthma, etc. The writers consider that the point has seven general functions of dispelling pathogen... The article introduces the writers’ experience in using Fengchi(GB 20) to treat sciatica,gastric ulcer and bronchial asthma, etc. The writers consider that the point has seven general functions of dispelling pathogenic wind, purging pathogenic fire, relieving the depressed liver-qi, resolvingthe phlegm, activating the blood, tranquilizing the mind, and checking spasm and c0nvulsion. It alsointroduces the manipulations and precautions of needling Fengchi. 展开更多
关键词 Acupuncture Acupoint therapy Fengchi(GB 20)
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TREATING 100 CASES OF HEADACHE BY MAINLY NEEDLING FENGCHI AND TAICHONG 认领 引用
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作者 单宝枝 刘敏勇 王杭红 《World Journal of Acupuncture-Moxibustion》 CAS 1996年第2期40-42,共3页
This article introduces the writers’ experience in treating 100 cases of headache bymainly needling Fengchi (GB 20) and Taichong (LR 3). It is considered in TCM that headache ismostly caused by pathogenic wind, and t... This article introduces the writers’ experience in treating 100 cases of headache bymainly needling Fengchi (GB 20) and Taichong (LR 3). It is considered in TCM that headache ismostly caused by pathogenic wind, and there is a saying of "no wind, no headache". The combinationof the two points can expel both endogenous and exogenous wind. So we treat headache mainly withneedling Fengchi and Taichong. The result is good, especially for cluster headache and psychicheadache.’ 展开更多
关键词 Headache Acupuncture therapy Fengchi Taichong
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WEI JIA'S EXPERIENCE ON THE APPLICATION OF FENGCHI (GB 20) 认领 引用
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作者 Zhang QiaobaoGuanghua Plastics Factory, Jiangxi 330100, China Xie Qiang, Shan BaozhiJiangxi College of TCM, Jiangxi 330006, China 《World Journal of Acupuncture-Moxibustion》 CAS 1994年第1期9-14,共6页
The article introduces Prof.Weijia’s experience in using Fengchi(GB 20)totreat gastric ulcer,bronchial asthma,sciatica,and alopecia,etc.He considers that the point has seven general functions of dispelling pathogenic... The article introduces Prof.Weijia’s experience in using Fengchi(GB 20)totreat gastric ulcer,bronchial asthma,sciatica,and alopecia,etc.He considers that the point has seven general functions of dispelling pathogenic wind,purging pathogenic fire,relieving the depressedliver-Qi,resolving the phlegm,activating the blood,tranquilizing the mind,and checking spasm andconvulsion.It also introduces some common diseases treated with needling Fengchi and adjunctpoints,manipulations,and precautions,etc.It Is a comparatively comprehensive summary of Prof.Wei Jia’s individual experience in wonderfully using Fengchi. 展开更多
关键词 Fengchi (GB 20) Acupoint therapy Acupuncture
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ACUPUNCTURE TREATMENT OF OCCIPITAL NEURALGIA WITH DAZHUI AND FENGCHI ACUPOINTS 认领 引用
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作者 黄南滨 《World Journal of Acupuncture-Moxibustion》 CAS 2002年第3期29-31,共3页
Objective: To explore therapeutic method for occipital neuralgia. Methods: A total of 90 occipital neuralgia patients were randomly divided into treatment group (n=60 cases) and control group (n=30). In treatment grou... Objective: To explore therapeutic method for occipital neuralgia. Methods: A total of 90 occipital neuralgia patients were randomly divided into treatment group (n=60 cases) and control group (n=30). In treatment group, Dazhui (GV 14) was punctured and stimulated with reinforcing method, and Fengchi (GB 20) punctured and stimulated with reducing needling method. In control group, the tender point was punctured and stimulated with reducing needling method. The acupuncture needles were retained for 30 min and the treatment was conducted once daily, with 10 times being a therapeutic course. Results: After one session of treatment, the markedly effective rates of treatment and control groups were 98% and 57% respectively. Comparison between two groups showed a considerable difference in the therapeutic effect (P<0.05). Conclusion: Acupuncture of Dazhui (GV 14) and Fengchi (GB 20) are effective in the treatment of occipital neuralgia. 展开更多
关键词 Occipital neuralgia Acupuncture treatment Dazhui (GV 14) and Fengchi (GB 20)
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Exploration of electroacupuncture at “Fengchi”(GB 20)and“Sishencong”(EX-HN 1) for attenuating learning and memory impairment in vascular dementia rats based on NMDAR/CREB/ BDNF signaling pathway 认领 引用
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作者 SONG Yuanyu 《China Medical Abstracts(Internal Medicine)》 2025年第1期3-4,共2页
Objective To explore the mechanism of electroacupuncture(EA)at"Fengchi"(GB20)and“Sishencong”(EX-HN 1)on learning and memory impairment in vascular dementia(VD)rats by observing the influences on the N-meth... Objective To explore the mechanism of electroacupuncture(EA)at"Fengchi"(GB20)and“Sishencong”(EX-HN 1)on learning and memory impairment in vascular dementia(VD)rats by observing the influences on the N-methyl-D-aspartate receptor(NMDAR)/cyclic adenosine monophosphate response element-binding protein(CREB)/brain-derived neurotrophic factor(BDNF)signaling pathway and the excitotoxicity induced by hippocampal calcium overload.Methods Thirty-two male SD rats of SPF grade were selected and randomized into a normal group(6 rats),a shamoperation group(6 rats)and an operation group(20 rats).VD model was established with the modified Pulsinelli's four-vessel occlusion(4-VO)method.Twelve rats after successfully modeled were assigned randomly into a model group and an EA group,6 rats in each one.In the EA group,EA was delivered at bilateral"Fengchi"(GB 20)and"Sishencong"(EX-HN 1),with the continuous wave,the frequency of 2 Hz and the electric current of 1 mA.Stimulation intensity was adjusted depending on the slightly trembling of rat head.EA was given once daily,30 min each time;and EA intervention was delivered for 21 days continuously.Using Morris water maze test,the learning and memory functionwas assessed.The neuronal morphology in the hippocampal CAl was observed with HE staining;the level of glutamate(GLU)in serum and hippocampal tissue,as well as the activity of calcium pump(Ca2+-ATP)in the hippocampus were detected using colorimetric method.Theprotein expression ofNMDAR,calmodulindependent protein kinase II(CaMK I),phosphorylated calmodulin-dependent protein kinase I(p-CaMK II),phosphorylated cyclic phosphoradenosine effector element binding proteins(p-CREB),CREB,,and BDNF in the hippocampal CA1 was detected using immunohistochemistry.The protein expression of NMDAR,CREB,p-CREB and BDNF in the hippocampal tissue was detected using Western blot method.Results Compared to the shamoperation group,in the model group,the escape latency was prolonged and the platform crossing times of rats were reduced(P<0.01),the hippocampal neuron structure was damaged to different degrees,the structure in hippocampal CA1 was loosened,the arrangement disorganized,with clear grid-like structure;the neuronal morphology was irregular,pyknosis and even dissolution occurred,glial cells increased,blood capillarywas dilated and the inflammatory cells were infiltrated and scattered.Thelevel of GLUintheserum and hippocampal tissue and the protein expression of hippocampal NMDAR were elevated(P<0.01),the activity of Ca2+-ATP and the protein expression of CaMK I,p-CaMK I,CREB,p-CREB and BDNFwere reduced(P<0.01,P<0.05);and the ratio of p-CaMK II/CaMK II and that of p-CREB/CREB were dropped(P<0.05).In comparison with the model group,in the EA group,the escape latency was shortened and the platform crossing times of rats rose(P<0.01),the arrangement was improved in the hippocampal CA1,the neuronal morphology was intact,the nucleoli were relatively clear and the pyknosis or dissolution were attenuated,the numbers of glial cells reduced relatively,the dilation of blood capillary was alleviated.The level of GLU in the serum and hippocampal tissue and the protein expression of NMDAR were reduced in the hippocampal tissue(P<0.01),the activity of Ca2+-ATP and the protein expression of CaMK II,p-CaMK I,CREB,p-CREB and BDNF were elevated(P<0.05,P<0.01);the ratio of p-CaMK II/CaMK II and that of p-CREB/CREB increased(P<0.05).Conclusion EA at"Fengchi"(GB 20)and"Sishencong"(EX-HN 1)can attenuate learning and memory impairment in VD rats,which may be obtained by reducing GLU level in hippocampal tissue,inhibiting hippocampal excitotoxicity,mediating protein expression related to the NMDAR/CREB/BDNFsignalingpathway,and maintaining neuronal survival and growth. 展开更多
关键词 Fengchi GB Excitotoxicity learning memory impairment Electroacupuncture NMDAR CREB BDNF Signaling Pathway Sishencong EX HN Vascular Dementia Learning Memory Impairment
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电针翳风、风池对急性期中重度周围性面瘫预后的影响:随机对照试验 认领 引用
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作者 刘静怡 郭淑贞 +4 位作者 邢御 潘婷 李阳 冯智伟 白鹏 《中国针灸》 CAS CSCD 北大核心 2026年第5期719-724,共6页
目的:观察电针翳风、风池对急性期中重度周围性面瘫患者预后的影响。方法:将68例急性期中重度周围性面瘫患者随机分为电针组(脱落2例,剔除1例)和针刺组(脱落2例,剔除1例)。两组均予西药基础治疗,在此基础上,两组均取患侧阳白、四白、颧... 目的:观察电针翳风、风池对急性期中重度周围性面瘫患者预后的影响。方法:将68例急性期中重度周围性面瘫患者随机分为电针组(脱落2例,剔除1例)和针刺组(脱落2例,剔除1例)。两组均予西药基础治疗,在此基础上,两组均取患侧阳白、四白、颧髎、颊车、地仓、翳风、风池等行常规针刺;电针组翳风、风池连接电针仪,予连续波,频率4 Hz,电流1~5 m A,电针20 min;针刺组则翳风、风池连接无电流输出的电针仪。两组均每周针刺2次,两次治疗间隔3 d,连续12周。治疗结束后12周,观察两组患者并发症发生率。分别于治疗前后比较两组患者Sunnybrook面神经评定量表评分、面部残疾指数(FDI)评分,并评定安全性。结果:电针组并发症发生率为6.5%(2/31),针刺组并发症发生率为16.1%(5/31),两组并发症发生率比较差异无统计学意义(P>0.05)。治疗后,两组患者Sunnybrook面神经评定量表总分,随意运动总分及抬额头、轻轻闭眼、张嘴微笑、耸鼻子、唇吸吮评分均较治疗前升高(P0.05)。结论:电针翳风、风池可有效促进急性期中重度周围性面瘫患者中下部面部肌肉随意运动恢复,改善其躯体运动功能与社会生活功能,具有较高的临床应用价值。 展开更多
关键词 急性期中重度周围性面瘫 电针 面瘫并发症 风池 翳风
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超声引导下精准针刺与推拿的协同治疗模式在寰枢椎错位中的临床价值 认领 引用
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作者 叶芝兰 江帆 +4 位作者 王建文 李梅 刘超逸 方徐鹏 刘丹 《中国医学创新》 CAS 2026年第18期23-28,共6页
目的:探讨超声引导下精准针刺与推拿的协同治疗模式在寰枢椎错位中的应用价值。方法:选取2022年6月—2025年5月景德镇市中医医院康复科接诊的寰枢椎错位患者192例为研究对象,通过随机数字表法分为针刺组、推拿组和联合组,各64例。针刺... 目的:探讨超声引导下精准针刺与推拿的协同治疗模式在寰枢椎错位中的应用价值。方法:选取2022年6月—2025年5月景德镇市中医医院康复科接诊的寰枢椎错位患者192例为研究对象,通过随机数字表法分为针刺组、推拿组和联合组,各64例。针刺组在超声引导下精准针刺风池穴,推拿组采用推拿治疗,联合组采用超声引导下精准针刺风池穴联合推拿治疗。三组均治疗4周。比较三组中医证候积分、疗效、生活质量(SF-36)、寰枢关节指标、颈部动脉血流速度。结果:联合组治疗后颈部活动不利、颈部疼痛、头晕、头痛评分低于针刺组与推拿组(P<0.05);联合组治疗后总有效率为71.88%,高于针刺组的56.25%和推拿组的43.75%(P<0.05);联合组治疗后躯体功能、躯体角色、一般健康状况评分高于推拿组与针刺组,寰齿前间隙、寰齿侧间隙差值、寰外侧关节间隙差值及寰枢椎相对旋转角度小于推拿组和针刺组(P<0.05);联合组治疗后左侧椎动脉(VA)、右侧VA及基底动脉(BA)血流速度快于针刺组与推拿组(P<0.05)。结论:超声引导下精准针刺与推拿的协同治疗能降低寰枢椎错位患者中医证候积分,提高疗效,改善寰枢关节错位,提高颈部动脉血流速度。 展开更多
关键词 超声引导 针刺 风池穴 推拿 寰枢椎错位
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三维定点旋转复位术结合短刺法治疗颈性眩晕 认领 引用
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作者 桂美琳 蒋涛 +2 位作者 倪璐 陈飞 郭庆军 《中医药临床杂志》 2026年第3期569-573,共5页
目的:观察三维定点旋转复位术结合短刺法治疗颈性眩晕的临床疗效。方法:80例颈性眩晕患者,随机分为观察组、对照组各40例。观察组予以三维定点旋转复位术结合短刺法,对照组口服盐酸氟桂利嗪胶囊,比较治疗前后颈性眩晕症状与功能评分(ES... 目的:观察三维定点旋转复位术结合短刺法治疗颈性眩晕的临床疗效。方法:80例颈性眩晕患者,随机分为观察组、对照组各40例。观察组予以三维定点旋转复位术结合短刺法,对照组口服盐酸氟桂利嗪胶囊,比较治疗前后颈性眩晕症状与功能评分(ESCV)、椎-基底动脉收缩期血流速度(Vp)、椎-基底动脉平均血流速度(Vm),评价临床疗效。结果:观察组总有效率(92.5%)优于对照组(77.5%),且治疗后观察组ESCV及Vp、Vm改善明显,与对照组比较差异均有统计学意义(P<0.05)。结论:三维定点旋转复位术结合短刺法治疗颈性眩晕有良好的临床疗效,并且明显优于对照组,可改善患者眩晕症状,提高患者生活质量。 展开更多
关键词 颈性眩晕 三维定点旋转复位术 短刺法 风池穴 临床研究
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风池穴治疗头痛的临床应用研究与机制探析 认领 引用
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作者 谢怡琳 万文蓉 《中国医学创新》 CAS 2026年第15期177-182,共6页
头痛是临床常见疾病,不仅具有较高的发病率与复发率,亦给患者的经济状况与生活质量带来沉重负担。大多数西药只能缓解症状,且存在较大副作用,停药后易复发。中医针刺治疗头痛效果显著且安全性高,古今文献检索显示,风池穴是最常用的治疗... 头痛是临床常见疾病,不仅具有较高的发病率与复发率,亦给患者的经济状况与生活质量带来沉重负担。大多数西药只能缓解症状,且存在较大副作用,停药后易复发。中医针刺治疗头痛效果显著且安全性高,古今文献检索显示,风池穴是最常用的治疗穴位。本文通过介绍风池穴与头痛相关的归经、穴位功效,以及其与现代医学中断层解剖、枕后三角、血流动力学、神经递质等相关性,探讨风池穴针刺的安全性及治疗头痛的相关配穴,分析风池穴治疗头痛的临床应用与机制,以优化临床治疗方案并降低治疗风险。 展开更多
关键词 风池穴 头痛 安全性 机制
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《伤寒论》第24条“先刺风池、风府”的多维诠析与针药智慧 认领 引用
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作者 方闯 潘江 +3 位作者 刘丽 付思思 刘惠娟 黄宇辉 《深圳中西医结合杂志》 2026年第1期47-50,共4页
《伤寒论》作为论述外感病的专著,其针灸论述较少且多为简略记载,深入研究其针灸条文具有独特意义。本文以第24条为切入点,从针刺与桂枝汤服用先后、腧穴名称释义、腧穴主治、开阖枢理论、现代医学角度来论述“先刺风池、风府”,从多维... 《伤寒论》作为论述外感病的专著,其针灸论述较少且多为简略记载,深入研究其针灸条文具有独特意义。本文以第24条为切入点,从针刺与桂枝汤服用先后、腧穴名称释义、腧穴主治、开阖枢理论、现代医学角度来论述“先刺风池、风府”,从多维度解析揭示针药时序智慧、选穴科学性及古今医学联系,以期为针药结合条文注释提供新思路。 展开更多
关键词 伤寒论 风池 风府 针药结合
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Effects of electroacupuncture at Fengchi(GB20)on motor function and GFAP/NeuN expression around the ischemic tissue of the motor cortex in MCAO rats 认领 引用
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作者 CHEN Lüjia HAO Lingyu +1 位作者 ZHANG Yingjie XU Mingshu 《Journal of Acupuncture and Tuina Science》 CAS CSCD 2024年第5期363-370,共8页
Objective:To investigate the potential mechanism of electroacupuncture(EA)at bilateral Fengchi(GB20)in treating cerebral ischemia-reperfusion injury and to provide a scientific basis for future experimental research a... Objective:To investigate the potential mechanism of electroacupuncture(EA)at bilateral Fengchi(GB20)in treating cerebral ischemia-reperfusion injury and to provide a scientific basis for future experimental research and clinical applications.Methods:Forty male specific-pathogen-free Sprague-Dawley rats were randomly divided into four groups:a normal group,a normal with EA group,a model group,and a model with EA group,with 10 rats in each group.The normal group received no intervention.The normal with EA group received EA at bilateral Fengchi(GB20).The model group underwent middle cerebral artery occlusion(MCAO)using the suture.The model with EA group underwent MCAO and received EA at bilateral Fengchi(GB20).Cerebral blood flow was monitored using a laser Doppler cerebral blood flow meter.Neurologic damage was assessed using the neurologic deficit score,and motor ability was observed using the CatWalk gait system.The expression of glial fibrillary acidic protein(GFAP)and neuronal nuclei(NeuN)protein,the neuron markers,was detected by Western blotting.The protein expression levels of GFAP and NeuN,as well as the number of positive cells in the motor cortex,were detected using immunofluorescence.Results:Compared to the normal group,the cerebral blood flow values in the model group and the model with EA group decreased by more than 50%during the modeling process(P0.05).The neurologic deficit score increased(P<0.05),the average motor velocity decreased(P<0.05),GFAP protein expression and the number of positive cells in the motor cortex increased(P<0.05),and the NeuN protein expression and the number of positive cells decreased(P<0.05)in the model group.Compared to the model group,the neurologic deficit score decreased(P<0.05),the average motor velocity accelerated(P<0.05),GFAP and NeuN protein expression and the number of positive cells in the motor cortex increased(P<0.01)in the model with EA group.Conclusion:EA at bilateral Fengchi(GB20)can reduce neuronal loss and increase GFAP and NeuN protein expression in the motor cortex of rats after ischemia-reperfusion,improve the motor function after ischemic stroke,and accelerate the recovery of balance and stability of the affected limbs. 展开更多
关键词 Electroacupuncture Point,Fengchi(GB20) Brain Ischemia Reperfusion Injury Cerebrovascular Circulation Motor Function Glial Fibrillary Acidic Protein Rats
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风池穴、翳风穴在周围性面瘫针灸治疗中的作用探究 认领 引用
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作者 尹丽凤 《科技与健康》 2026年第7期117-120,共4页
研究分析风池穴、翳风穴在周围性面瘫针灸治疗中的作用。将60例在连云港市赣榆区人民医院接受治疗的周围性面瘫患者选为研究对象,以2023年1月—2025年4月为研究时间,随机将其分为参照组与观察组,每组30例。参照组实施常规针灸治疗,观察... 研究分析风池穴、翳风穴在周围性面瘫针灸治疗中的作用。将60例在连云港市赣榆区人民医院接受治疗的周围性面瘫患者选为研究对象,以2023年1月—2025年4月为研究时间,随机将其分为参照组与观察组,每组30例。参照组实施常规针灸治疗,观察组实施温针灸+风池穴、翳风穴治疗,统计对比两组患者的临床疗效、中医证候积分、面部血流灌注量、面神经功能。结果显示,观察组临床治疗总有效率显著高于参照组(P<0.05)。治疗后,观察组的中医证候积分明显低于参照组,健侧与患侧面部血流灌注量均大于参照组,面神经功能明显优于参照组(P<0.05)。研究发现,周围性面瘫患者应用温针灸+风池穴、翳风穴的效果更确切,不仅可以减轻症状,还可以增加面部血流灌注量,改善面神经功能,具有极高的临床借鉴与推广价值。 展开更多
关键词 周围性面瘫 温针灸 风池穴 翳风穴 面神经功能
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中医推拿一指禅推法定点风池穴下的生物力学特征 认领 引用 被引量：4
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作者 石梦妮 孙武权 +4 位作者 李静先 郭蕾 吴志伟 房敏 朱清广 《医用生物力学》 CAS CSCD 北大核心 2025年第2期456-461,共6页
目的系统研究一指禅推法在风池穴定点操作下不同施力条件下的生物力学特性,以提供精准量化数据,提升治疗效果。方法招募10名具有高级职称的推拿医师,应用德国Novel Pliance-X 32 Expert手套动态压力分布测量系统,记录推拿医师在风池穴... 目的系统研究一指禅推法在风池穴定点操作下不同施力条件下的生物力学特性,以提供精准量化数据,提升治疗效果。方法招募10名具有高级职称的推拿医师,应用德国Novel Pliance-X 32 Expert手套动态压力分布测量系统,记录推拿医师在风池穴定点执行一指禅推法时,轻、中、重3种施力强度下3 min力学参数。数据分析选取力学输出稳定的中段1 min数据,评估最大压力、平均压力、峰值压强、平均压强、压力-时间积分(force-time integral,FTI)、压强-时间积分(pressure-time integral,PTI)及操作频率等关键力学指标。结果在轻、中、重3种施力条件下,高级职称推拿医师在风池穴定点操作的一指禅推法的最大压力均值分别为6.31、9.45、18.27 N,平均压力均值分别为3.31、5.64、9.05 N;峰值压强均值为26.10、34.80、70.00 kPa,平均压强均值为11.95、21.00、26.15 kPa;FTI均值为55.65、182.10、225.21 N·s;PTI均值为167.10、489.59、795.83 kPa·s;操作频率均值分别为156.00、150.60、154.80次/min。结论10名高级职称推拿医师在轻、中、重3种手法的自我界定和客观测量力学参数之间表现出较高的一致性,反映了推拿医师在不同施力条件下对手法力度的精确掌控,验证了一指禅推法在实际应用中的可操作性与可重复性,为量化研究和制定规范化临床操作标准提供可靠依据。 展开更多
关键词 推拿 一指禅推法 风池穴 中医 生物力学
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电针“风池”“外关”“阳陵泉”对慢性偏头痛模型大鼠痛觉敏化和三叉神经节PKC/TRPV1通路的影响 认领 引用 被引量：5
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作者 曾翼翔 涂润泽 +7 位作者 赵书聪 杨阳 文皓佳 贺卓众 周胜利 谭磊 何可 付磊 《中医杂志》 CSCD 北大核心 2025年第3期283-289,共7页
目的 从痛觉敏化角度探讨电针风池、外关、阳陵泉治疗慢性偏头痛的可能作用机制。方法 将40只SPF级SD大鼠随机分为空白组、模型组、电针组、电针+激动剂组、抑制剂组,每组8只。除空白组外,其余各组大鼠采用腹腔注射硝酸甘油建立慢性偏... 目的 从痛觉敏化角度探讨电针风池、外关、阳陵泉治疗慢性偏头痛的可能作用机制。方法 将40只SPF级SD大鼠随机分为空白组、模型组、电针组、电针+激动剂组、抑制剂组,每组8只。除空白组外,其余各组大鼠采用腹腔注射硝酸甘油建立慢性偏头痛大鼠模型。大鼠造模成功后,电针组予电针双侧“风池”“外关”“阳陵泉”,每次30 min;电针+激动剂组在电针组的基础上经眶下孔注射蛋白激酶C (PKC)激动剂Phorbol 12-myristate 13-acetate Abcam (1.0 ng/μl) 25μl;抑制剂组经眶下孔注射PKC抑制剂Chelerythrine Chloride (1.0 ng/μl) 10μl;空白组、模型组、抑制剂组均予捆绑束缚30 min,不做其他干预。各组均连续干预5天。干预结束后对大鼠进行眶周、后足机械痛阈值及后足热痛阈值测定;分别运用Western Blot法、实时荧光定量PCR法、免疫荧光法检测三叉神经节组织中瞬时受体电位香草酸亚型1 (TRPV1)、磷酸化瞬时受体电位香草酸亚型1 (p-TRPV1)、PKC蛋白水平,Trpv1、Pkc mRNA表达以及TRPV1、PKC平均荧光强度。结果 与空白组比较,模型组大鼠眶周、后足机械痛阈值及后足热痛阈值均降低,三叉神经节组织中TRPV1、PKC、p-TRPV1蛋白水平,Trpv1、Pkc mRNA表达以及TRPV1、PKC平均荧光强度均升高(P<0.05或P<0.01)。与模型组比较,电针组大鼠眶周、后足机械痛阈值及后足热痛阈值均升高,三叉神经节组织中TRPV1、PKC、p-TRPV1蛋白水平,Trpv1、Pkc mRNA表达以及TRPV1平均荧光强度均降低;电针+激动剂组大鼠三叉神经节组织中TRPV1平均荧光强度降低;抑制剂组大鼠眶周机械痛阈值和后足热痛阈值升高,三叉神经节组织中TRPV1、PKC、p-TRPV1蛋白水平以及TRPV1、PKC平均荧光强度均降低(P<0.05或P<0.01)。与电针组比较,电针+激动剂组大鼠三叉神经节组织中TRPV1、PKC、p-TRPV1蛋白水平以及Trpv1 mRNA表达均升高(P<0.05或P<0.01)。结论 电针“风池”“外关”“阳陵泉”可提高慢性偏头痛大鼠机械痛阈值及热痛阈值,减弱痛觉敏化,其机制可能与抑制PKC/TRPV1通路有关。 展开更多
关键词 慢性偏头痛 痛觉敏化 电针 瞬时受体电位香草酸亚型1 蛋白激酶C 风池 外关 阳陵泉
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多功能套针浮刺治疗颈性眩晕的疗效观察 认领 引用 被引量：3
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作者 王鑫蕊 陈英华 +1 位作者 孙玮 杨建宇 《上海针灸杂志》 CSCD 2025年第5期556-562,共7页
目的基于经筋理论观察多功能套针浮刺治疗颈性眩晕的临床疗效。方法将180例颈性眩晕患者采用随机数字表法随机分为套针浮刺组与常规针刺组,每组90例。套针浮刺组采用多功能套针浮刺疗法,常规针刺组则采用常规针刺疗法。观察两组治疗前... 目的基于经筋理论观察多功能套针浮刺治疗颈性眩晕的临床疗效。方法将180例颈性眩晕患者采用随机数字表法随机分为套针浮刺组与常规针刺组,每组90例。套针浮刺组采用多功能套针浮刺疗法,常规针刺组则采用常规针刺疗法。观察两组治疗前后颈性眩晕评估量表(evaluation scale for cervical vertigo,ESCV)、眩晕残障程度评定量表(dizziness handicap inventory,DHI)、眩晕症状量表(vertigo symptom scale,VSS)评分变化,采用经颅多普勒超声检测双侧椎动脉血流速度,并比较两组临床疗效。结果套针浮刺组总有效率、愈显率分别为96.7%、81.1%,常规针刺组分别为88.9%、62.2%,且套针浮刺组均优于常规针刺组(P<0.05)。治疗后,两组ESCV评分较治疗前均升高(P<0.05),且套针浮刺组高于常规针刺组(P<0.05)。治疗后,两组DHI评分较治疗前均降低(P<0.05),且套针浮刺组低于常规针刺组(P<0.05)。治疗后,两组VSS评分较治疗前均降低(P<0.05),且套针浮刺组评分低于常规针刺组(P<0.05)。治疗后,两组双侧椎动脉血流速度较治疗前均增快(P<0.05),且套针浮刺组双侧椎动脉血流速度均快于常规针刺组(P<0.05)。结论多功能套针浮刺治疗颈性眩晕临床疗效更优,可以减轻眩晕症状和眩晕程度,改善椎动脉血流速度。 展开更多
关键词 眩晕 颈椎病 经筋理论 针刺疗法 浮刺 穴,风池 穴,手三里
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电针风池穴通过STAT6/NF-κB信号通路调节小胶质细胞M1/M2型极化改善大鼠脑梗死 认领 引用 被引量：1
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作者 黄晋 潘静洁 刘堂营 《广州中医药大学学报》 CAS 2025年第8期1998-2005,共8页
【目的】观察电针风池穴对脑梗死大鼠的治疗作用及机制。【方法】将80只雄性SD大鼠随机分为正常组、模型组、电针组(电针风池穴)和电针+AS1517499[信号转导及转录激活因子6(STAT6)抑制剂]组(电针风池穴+腹腔注射AS1517499),每组20只。... 【目的】观察电针风池穴对脑梗死大鼠的治疗作用及机制。【方法】将80只雄性SD大鼠随机分为正常组、模型组、电针组(电针风池穴)和电针+AS1517499[信号转导及转录激活因子6(STAT6)抑制剂]组(电针风池穴+腹腔注射AS1517499),每组20只。除正常组,其他各组大鼠采用线栓法建立脑梗死模型。造模结束后,进行分组干预。干预结束后,观察大鼠神经功能缺损程度,氯化三苯基四氮唑(TTC)染色法测定脑梗死面积,苏木精-伊红(HE)染色法观察脑组织病理变化,脱氧核糖核苷酸末端转移酶介导的缺口末端标记(TUNEL)染色法测定脑细胞凋亡率,酶联免疫吸附分析(ELISA)检测脑组织白细胞介素6(IL-6)、γ干扰素(IFN-γ)、白细胞介素4(IL-4)、转化生长因子β(TGF-β)水平,Western Blot法检测脑组织小胶质细胞标志物离子钙结合接头分子1(Iba-1)、CD86、CD206以及STAT6/核因子κB(NF-κB)信号通路相关蛋白STAT6、磷酸化STAT6(p-STAT6)、过氧化物酶体增殖物激活受体γ(PPAR-γ)、磷酸化核因子κB p65(p-NF-κB p65)的蛋白表达水平。【结果】与正常组比较,电针组神经功能缺损评分、脑梗死面积、脑细胞凋亡率以及脑组织促炎症因子IL-6、IFN-γ水平显著升高,抗炎因子IL-4、TGF-β水平显著降低,M1小胶质细胞标志物CD86以及信号通路相关蛋白p-NF-κB p65表达水平显著升高,M2小胶质细胞标志物CD206以及信号通路相关蛋白STAT6、p-STAT6、PPAR-γ表达水平显著下降,差异均有统计学意义(P<0.05)。与模型组比较,电针组神经功能缺损评分、脑梗死面积、脑细胞凋亡率以及脑组织促炎症因子IL-6、IFN-γ水平显著降低,IL-4、TGF-β水平显著升高,CD86及p-NF-κB p65表达水平显著下降,CD206及STAT6、p-STAT6、PPAR-γ表达水平显著上升,差异均有统计学意义(P<0.05)。电针组的上述指标治疗效果均显著优于电针+AS1517499组。【结论】电针风池穴可通过调节STAT6/NF-κB信号通路使M1型小胶质细胞向M2型转化,从而改善大鼠脑梗死。 展开更多
关键词 电针 脑梗死 风池穴 STAT6/NF-κB信号通路 小胶质细胞 大鼠
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