In December 2025,the White House released the National Security Strategy for Trump's second term.The United States shifted the focus of its national security strategy from external competition to internal restruct...In December 2025,the White House released the National Security Strategy for Trump's second term.The United States shifted the focus of its national security strategy from external competition to internal restructuring—both within the United States and within the Western world.The goal was not to abandon the pursuit of global dominance but rather to repair the foundations of American hegemony in terms of power foundation,political ideology,and alliance management.It aims to forge a low-cost,selective,and transactional form of American hegemony.Compared to the National Security Strategies during the Biden administration and Trump's first term,the new report's narrative regarding China is relatively more measured.However,China remains viewed by the Trump administration as the most significant competitor.The United States will intensify its competition with China in economic and technological spheres,strengthen its military deterrence against China in the“Indo–Pacific”region,and exert pressure on China's influence in the Western Hemisphere and other regions.The Sino–US strategic competition is evolving into a new dynamic characterized by long-term competition,mutual balances,and selective engagement.China must analyze the complex implications of the Trump administration's strategic adjustments,enhance its capabilities,and refine its policy toolkit toward the United States.It is necessary to explore new models for“managed cooperation”between China and the United States.展开更多
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4uclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.展开更多
Modern agriculture relies heavily on resource-intensive and environmentally harmful inputs,while the increasing global population and decreasing arable land demand new strategies to improve sustainable productivity of...Modern agriculture relies heavily on resource-intensive and environmentally harmful inputs,while the increasing global population and decreasing arable land demand new strategies to improve sustainable productivity of cereal crops,particularly reducing inorganic nitrogen fertilizer use while simultaneously increasing photosynthesis and grain yield in rice.To improve rice productivity,it is essential to improve photosynthetic nitrogen assimilation and optimize the translocation of carbon and nitrogen products from source to sink tissues.In this review,we first summarize recent advances in the genetic basis for improving grain yield by enhancing photosynthetic carbon and nitrogen assimilation.We then discuss progress in modulating the source-sink relationships to achieve higher yield and improved harvest index.Finally,we explore the necessary optimizations for adapting rice to high-density planting.These advancements are driving the development of sustainable green revolution varieties through the rational design of multi-gene pyramids and artificial intelligence-driven protein engineering.展开更多
Against the backdrop of the accelerating global clean energy transition and the rapid increase in renewable energy source(RES)penetration,temporal imbalances between supply and demand in power systems are becoming inc...Against the backdrop of the accelerating global clean energy transition and the rapid increase in renewable energy source(RES)penetration,temporal imbalances between supply and demand in power systems are becoming increasingly prominent.Consequently,the phenomenon of negative electricity prices has evolved from sporadic occurrences into an increasingly prevalent market signal.This paper focuses on case studies of negative electricity prices in major international electricity markets(the Netherlands,Germany,Australia)and selected provincial markets in China(Shandong,Zhejiang).It systematically analyzes their underlying causal mechanisms,assesses their multidimensional impacts,and comparatively examines the mitigation strategies adopted across these diverse markets.The study reveals that the core driver of negative prices is the concentrated high generation feed-in from RES during low-load periods.This is concurrently influenced by multiple factors,including insufficient system flexibility,inter-zonal transmission congestion,and constraints imposed by specific market rules such as subsidies and bidding strategies.Major international electricity markets are widely exploring mitigation measures such as optimizing market clearing mechanisms,incentivizing energy storage and demand-side response,and adjusting subsidy policies.In contrast,the occurrence of negative prices in China’s electricity markets,while sharing common drivers,also exhibits complex correlations with domestic factors,notably medium-and long-term contracts and market power dynamics.Consequently,formulating and implementing differentiated and systematic mitigation strategies,drawing upon international experience while being tailored to China’s specific national context,is crucial for the long-term sustainable development of its electricity markets.展开更多
This paper examines Xinjiang's advantageous and characteristic agriculture from grain production functional zones,important agricultural product protection zones,characteristic agricultural product advantageous zo...This paper examines Xinjiang's advantageous and characteristic agriculture from grain production functional zones,important agricultural product protection zones,characteristic agricultural product advantageous zones,hometowns of specialty products,One Village One Product,regional public brands,famous,special,premium,and novel agricultural products,characteristic agricultural products,agricultural product quality and safety,Taste of Xinjiang,Good Grain and Oil,and industrial clusters.Besides,from geographical indications,design patents(for packaging and containers),and trademarks,this paper studies the autonomous region's brand mark-related agricultural intellectual property.It also analyzes the main problems in the development of its brand agriculture,and puts forward suggestions such as building a diversified food supply system,improving the protection of geographical indication intellectual property rights,promoting the creation of design patents for packaging and containers,strengthening the registration of regional public trademarks and Madrid international trademarks,and carrying out targeted counterpart assistance to Xinjiang for characteristic agriculture.展开更多
Nickel-based superalloys(Ni-based superalloys)have attracted extensive attention in laser additive manufacturing(LAM)due to their capability to directly fabricate complex and high-performance structural components.How...Nickel-based superalloys(Ni-based superalloys)have attracted extensive attention in laser additive manufacturing(LAM)due to their capability to directly fabricate complex and high-performance structural components.However,the rapid melting and solidification inherent to LAM result in intense thermal cycling,which induces high residual stresses and microstructural heterogeneity within the fabricated parts.Among them,cracks,as the most destructive defects,can have a typical crack density of over five per mm2 without optimized processes.Moreover,the sudden failures of components caused by cracks account for more than 40%of the total failures of additively manufactured nickel-based superalloy components.They can rapidly expand along grain boundaries or brittle phases,significantly weakening the mechanical properties of components and causing sudden failures.To achieve highly reliable additive manufacturing components,it is essential to conduct in-depth research on the types,formation mechanisms of cracks in Ni-based superalloys,and their relationships with microstructure,residual stress,etc.This paper systematically reviews the crack characteristics and formation mechanisms of Ni-based superalloys during the laser additive manufacturing process,post-manufacturing,and service stages and comprehensively summarizes the current mainstream crack suppression strategies,specifically including process parameter optimization,residual stress regulation,alloy composition design,and subsequent post-treatment technologies,as well as incorporating emerging machine learning-assisted methods.The review aims to provide theoretical insights and technical guidance toward the development of crack-free Ni-based superalloy components fabricated by laser additive manufacturing.展开更多
Ultraviolet(UV)nonlinear optical(NLO)crystals have received substantial interest in advanced laser technology.However,tailoring a UV NLO material with a large second harmonic generation(SHG)response and good UV transp...Ultraviolet(UV)nonlinear optical(NLO)crystals have received substantial interest in advanced laser technology.However,tailoring a UV NLO material with a large second harmonic generation(SHG)response and good UV transparency remains a challenge.Here,inspired by the classic A3-RE2-[BO3]3 parent template,two new rare-earth borate NLO crystals,RbNa2La2(BO3)3(RNLBO-Ⅰ)and Rb0.681Na2.319La2(BO3)3(RNLBO-Ⅱ),were extracted by merging larger ionic radius cations Rb+and La3+simultaneously using a chemical substitution-oriented strategy.As expected,both compounds achieve significant enhancements in SHG activities,reaching 4.5×and 4.3×KDP,respectively,exceeding three times that of the isomorphic Na3Gd2B3O9.Notably,RNLBO-Ⅰdisplayed the highest SHG response among alkali metal RE-borate NLO crystals containing isolated[BO3]groups in the short-wave UV region.Moreover,RNLBO-Ⅰand-Ⅱdemonstrated short UV cutoff edges at 213 and 207 nm,corresponding to wide bandgaps of 5.3 and 5.6 eV,respectively.Additionally,theoretical calculations and dipole moment analysis were conducted to clarify the origin of the enhanced SHG activities of RNLBO-Ⅰand-Ⅱ.The optimal balance between SHG intensity and UV transparency in RNLBO-Ⅰand-Ⅱunderscores their potential as UV NLO candidates and offers valuable insights for fabricating new advanced UV NLO materials.展开更多
To advance shipping decarbonization,hydrogen is increasingly recognized as a viable zero-carbon fuel.Currently,a hydrogen/diesel dual-fuel medium-speed engine represents an optimal prime mover for ships.However,challe...To advance shipping decarbonization,hydrogen is increasingly recognized as a viable zero-carbon fuel.Currently,a hydrogen/diesel dual-fuel medium-speed engine represents an optimal prime mover for ships.However,challenges such as the large cylinder dimensions of marine medium-speed engines and the low temperatures at the combustion chamber walls can hinder efficient flame propagation,leading to the emission of unburnt hydrogen.This not only diminishes the engine's mechanical output but also poses significant safety risks.To address these issues,this study employs computational fluid dynamics(CFD)modelling to explore optimal diesel injection strategies that minimize unburnt hydrogen emissions in such engines.Specifically,this research examines the impacts of the diesel injection start angle,spray tilt angle,and injection duration on hydrogen combustion efficiency.The findings reveal that fine-tuning injection parameters substantially lower the fraction of unburned hydrogen.Adjusting the injection timing from 9.5°CA BTDC to 49.5°CA BTDC decreases the unburnt hydrogen fraction from 50%to 3%.Furthermore,modifying the spray tilt angle from 75.5°to 55.5°further decreases it to 2%,while shortening the injection duration from 35°CA to 34°CA achieves the lowest unburnt hydrogen fraction at just 1%.These results underscore the effectiveness of diesel injection strategies in optimizing the combustion in hydrogen/diesel dual-fuel marine medium-speed engines,offering a pathway for similar applications in the sector.展开更多
Traditional knowledge, biological genetic resources and folk literature and art are intellectual property rights of cultural heritage that can be shared by regional groups without time limit. This paper studies the tr...Traditional knowledge, biological genetic resources and folk literature and art are intellectual property rights of cultural heritage that can be shared by regional groups without time limit. This paper studies the traditional knowledge and cultural heritage of Xinjiang agriculture from the aspects of traditional knowledge, important agricultural heritage system, intangible cultural heritage, biological genetic resources, tangible cultural heritage, frontier development and defense culture, and cultural tourism resources. It analyzes the main problems existing in the protection and inheritance of them, and puts forward suggestions such as inheriting and sharing intellectual property rights of cultural heritage, improving the protection system of biological germplasm resources, establishing national-level cultural ecological protection (experimental) zones, promoting agricultural science and technology cultural exchanges, creating Xinjiang's characteristic Great Wall culture, deeply integrating "agriculture+culture+tourism", building national and autonomous region cultural parks, and dynamically inheriting agricultural cultural heritage.展开更多
The escalating issue of drug-resistant pathogens,largely driven by the overuse of conventional antibiotics,has become a significant global health threat.Developing alternative therapeutic strategies and fabricating na...The escalating issue of drug-resistant pathogens,largely driven by the overuse of conventional antibiotics,has become a significant global health threat.Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency,selectivity,and mild-operating conditions of natural enzymes is a promising approach but presents a significant challenge.Nanozymes—nanomaterials exhibiting enzyme-like catalytic activities—have emerged as innovative therapeutic platforms combining intrinsic antimicrobial properties with enhanced drug delivery capabilities.This review systematically elaborates on the concept,evolution,classification,and design synthesis strategy of antibacterial nanozymes,ranging from the nanoscale to the atomic scale,with a focus on their morphology,structure,catalytic activity,antimicrobial properties,stability,and reusability.It examines the antimicrobial mechanisms of nanozymes across three primary pathways:oxidative stress induction,metal ion release,and nonoxidative interactions,and further explores the synergistic outcomes enabled by their multimodal integration.It also evaluates the enhanced antibacterial effects achieved by nanozyme-antibiotic composites(NACs)—engineered hybrid systems that combine nanozymes with traditional antibiotics.Key synergistic mechanisms include increased reactive oxygen species(ROS)production alongside glutathione(GSH)depletion,enhanced antibiotic retention for controlled release,and membrane disruption to facilitate drug entry,resulting in a more potent"1+1>2"effect.Clinical applications of antibacterial nanozymes and NACs are also discussed,focusing on their potential to combat drug-resistant infections.Ultimately,the review identifies current research gaps and proposes future directions,highlighting the crucial role of these nanozyme-based therapies in advancing global efforts against drug-resistant infections.展开更多
Muscle and bone,key tissues that maintain the body’s structure and function,are closely connected via mechanical and biochemical interactions.The vascular system plays a crucial role in musculoskeletal health,not onl...Muscle and bone,key tissues that maintain the body’s structure and function,are closely connected via mechanical and biochemical interactions.The vascular system plays a crucial role in musculoskeletal health,not only by providing nutrients and oxygen but also by regulating growth,regeneration,and metabolism.This review systematically examines the vascular structure and function of the musculoskeletal system,and explores the complex biochemical signaling networks involving myokines,osteokines,and vascular‑derived factors.Vascular dysfunction is a key contributor to the pathogenesis of degenerative diseases like sarcopenia(SP)and osteoporosis(OP),making vascular‑targeted therapies a promising approach for their treatment.Potential strategies for restoring vascular health include molecular targeting,exercise training,nutritional supplementation,cardiovascular pharmacotherapy,hormone therapies,and tissue engineering—all of which may help slow aging‑related musculoskeletal degeneration.Despite significant research progress,challenges remain in the clinical translation of these interventions.Future research should focus on elucidating the molecular mechanisms of muscle‑bone‑vascular interactions and exploring innovative tissue engineering techniques.This review provides a comprehensive understanding of the dynamic interactions between muscle,bone,and vascular systems,highlighting the importance of vascular health in musculoskeletal disease management,and proposes novel vascular‑targeted approaches for the prevention and treatment of musculoskeletal disorders.展开更多
Highlights Os GATA15 plays an important role in regulating the growth and development of the rice fiag leaf.The small flag leaf restorer line NP27 offers a novel breeding strategy and germplasm resource for hybrid ric...Highlights Os GATA15 plays an important role in regulating the growth and development of the rice fiag leaf.The small flag leaf restorer line NP27 offers a novel breeding strategy and germplasm resource for hybrid rice seed production without leaf-cutting.Rice is one of the main food crops globally.With the continuous increase in population and the decrease in effective arable land area,increasing rice yield is necessary to ensure the food supply(Wing et al.2018).展开更多
Lignin is a major by-product of industries such as pulping and biomass refining.However,currently,its high-value utilization rate remains extremely low.Owing to its high carbon content and unique natural aromatic stru...Lignin is a major by-product of industries such as pulping and biomass refining.However,currently,its high-value utilization rate remains extremely low.Owing to its high carbon content and unique natural aromatic structure,lignin serves as an ideal biomass-derived precursor for preparing porous carbon electrodes for supercapacitors.Existing relevant reviews are lacking in systematic correlation analysis between the characteristics of lignin precursors and the structural evolution of carbon materials,as well as the systematic sorting of their performance enhancement technologies.Centering on the multi-scale structural engineering of lignin-derived porous carbon electrodes,this review systematically summarizes the key technological advancements in improving their supercapacitive performance.It emphasizes elaborating on the structural and performance differences of porous carbons derived from four types of industrial lignin(lignosulfonate,enzymatic hydrolysis lignin,alkali lignin,and organosolv lignin),as well as the research status and regulation mechanisms of three core technologies,including pore structure regulation,surface modification,and composite strategies.Meanwhile,the current core challenges in this field,such as raw material consistency,the balance between pore structure and conductivity,large-scale production,and the standardization of performance evaluation,are analyzed,and four targeted future development directions are proposed:green synthesis approaches,intelligent structural design,device integration,and full life cycle assessment.This review aims to provide theoretical insights and technical references for the design of high-performance lignin-based supercapacitor electrode materials,thereby promoting the efficient,sustainable,and high-value utilization of industrial lignin resources.展开更多
Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employe...Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr0.2Ti0.8O3-0.9Ba0.7Ca0.3TiO3)ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L3H7 configuration achieving an open circuit voltage(VOC)of 23.13 V and a short circuit current(ISC)of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.展开更多
This paper introduces the current development status of new quality productive forces in agriculture,animal husbandry,and aquaculture in Xinjiang.It studies the development momentum of the seed industry in the autonom...This paper introduces the current development status of new quality productive forces in agriculture,animal husbandry,and aquaculture in Xinjiang.It studies the development momentum of the seed industry in the autonomous region from aspects,including seed industry array-type enterprises,breeding and seed production bases,crop varieties,and seed production and operation.It also explores the current situation of intellectual property rights related to scientific and technological innovation in Xinjiang,covering new varieties of agricultural plants,forest and grass plants,livestock and poultry,bees,silkworms,and aquatic animals and plants,as well as invention patents,utility model patents,and design patents for the product itself.Based on an analysis of the main problems facing its new quality productive forces and sci-tech innovation,recommendations are put forward,including managing the agricultural ecological environment according to local conditions,developing facility agriculture and smart agriculture,strengthening the purification and rejuvenation of traditional varieties and the introduction and acclimatization of new varieties,cultivating varieties with independent intellectual property rights,protecting invention patents and utility model patents,creating design patents for the product itself,and empowering the development of agricultural new quality productive forces.展开更多
Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence condition...Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence conditions that occur during flooding,particularly at the germination and vegetative stages.Anaerobic environments hinder seedling establishment during germination,while prolonged submergence during the vegetative stage impairs growth,ultimately reducing yield and grain quality.These stresses,driven by extended inundation,trigger a cascade of detrimental physiological responses and represent a major barrier to stable rice production and global food security.In this review,we examine the effects of flooding on rice growth at both the germination and vegetative stages.We further summarize recent advances in the identification of flooding-tolerant germplasm,QTL mapping,genome-wide association study,transcriptomic and proteomic analyses,and other molecular studies.Subsequently,we highlight potential cultivation and regulatory strategies,including genetic,morphological,physiological,and endogenous hormone-related approaches,aimed at enhancing tolerance to anaerobic and submergence stress.Together,these approaches underscore the promise of integrating molecular insights with agronomic practices to mitigate flooding damage and support sustainable rice production.展开更多
This paper addresses the protection-strategy-based distributed state estimation(SE)problem for time-varying nonlinear complex networks,where uncertain inner coupling and random false data injection attacks are conside...This paper addresses the protection-strategy-based distributed state estimation(SE)problem for time-varying nonlinear complex networks,where uncertain inner coupling and random false data injection attacks are considered.Owing to the fact that the measurement signals can be easily injected with false data by potential attackers before being transmitted to the estimator,a novel protection strategy is firstly proposed from the perspective of the defender to mitigate the effects of malicious attacks on the estimation performance.Based on the proposed protection strategy,more suspicious and unreliable measurements received are identified and discarded respectively.Accordingly,the zero-order holder strategy is employed to compensate for the discarded measurements.Subsequently,the purpose of this paper is to design a protection-strategy-based distributed SE scheme such that an optimized upper bound(UB)on the estimation error covariance(EEC)is obtained.Furthermore,a sufficient criterion is provided to guarantee the uniform boundedness of UB on the EEC.Finally,a localization problem involving multiple mobile robots is used to demonstrate the effectiveness and practicality of proposed variance-constrained optimized SE method.展开更多
Cochleovestibular impairment is a debilitating sequela of oncological intervention,resulting from multifaceted organic damage to the inner ear.Clinically manifesting as sensorineural hearing loss and vestibular dysfun...Cochleovestibular impairment is a debilitating sequela of oncological intervention,resulting from multifaceted organic damage to the inner ear.Clinically manifesting as sensorineural hearing loss and vestibular dysfunction,ototoxicity significantly compromises cognitive health and long-term quality of life.Despite its prevalence,early detection and prophylactic intervention remain clinically suboptimal.This review provides a comprehensive analysis of the molecular pathogenesis and risk factors—including age,specific genetic polymorphisms,and cumulative dosage—associated with various cancer modalities such as platinum-based chemotherapy,radiotherapy,and emerging immunotherapies.We specifically evaluate the cellular mechanisms of cisplatin-induced irreversible damage to the stria vascularis and hair cells.Furthermore,this article critiques current clinical monitoring protocols,advocating for the integration of baseline audiological screening and high-frequency auditory assessments as mandatory standards of care.Finally,we synthesize the current therapeutic landscape,ranging from established otoprotective agents and cochlear implants to novel candidate drugs in the preclinical pipeline.By bridging mechanistic research with translational evidence,this review emphasizes a precision-medicine approach to balance therapeutic efficacy with the preservation of auditory integrity for cancer survivors.展开更多
The traditional method of performance degradation prediction and maintenance of rolling bearings only considers a single sensor signal,which makes it difficult to automatically partition degradation stages and prone t...The traditional method of performance degradation prediction and maintenance of rolling bearings only considers a single sensor signal,which makes it difficult to automatically partition degradation stages and prone to over-detection.A new method of performance degradation evaluation and maintenance of rolling bearings based on data-level fusion,adaptive health state partitioning,and state maintenance is proposed.Firstly,considering the degradation and impact in the process of bearing deterioration,the multi-sensor signals are dynamically weighted to achieve data-level fusion.Secondly,a bearing health index was established based on fast spectral correlation,Wasserstein distance,and linear rectification techniques.On this basis,by combining the Bayesian information criterion and the elbow rule,the precise division of rolling bearing health state is realized through hidden Markov model regression.Then,random forest was used to classify and predict the data to verify the validity of the proposed data fusion method and health indicator.Finally,condition-based maintenance strategy based on the fourth moment,stress-strength interference model,and Gamma process is proposed to avoid excessive detection and reduce maintenance costs.Through accelerated degradation experiments and field validation tests on the rolling bearing test data set of Xi’an Jiaotong University and FEMTO(PRONOSTIA),the accuracy and superiority of the proposed method in the prediction and maintenance of bearing health state are verified.展开更多
The global rise in obesity and its associated metabolic syndrome has garnered significant attention in recent years.Targeting the gut microbiota has been proposed as a promising strategy for the treatment of obesity a...The global rise in obesity and its associated metabolic syndrome has garnered significant attention in recent years.Targeting the gut microbiota has been proposed as a promising strategy for the treatment of obesity and its related metabolic disorders.Bifidobacterium,one of the typical intestinal microorganisms in healthy individuals,has been recognized for its beneficial role in maintaining overall health.Numerous animal and human studies have elucidated the beneficial impact of bifidobacteria in maintaining the physiological and metabolic well-being of the host.Previous studies have found that bifidobacteria play a crucial role in regulating intestinal microbial communities and metabolism,as well as alleviating obesity by managing appetite,improving insulin resistance,modulating cholesterol and lipid metabolism,reshaping immune marker levels,and reducing inflammation.However,there remains a lack of comprehensive exploration into the potential correlation between bifidobacteria and obesity.By exploring the link between bifidobacteria and obesity based on recent research,this review aims to provide a theoretical foundation for elucidating the fundamental mechanisms underlying probiotic bifidobacteria intervention and promote the therapeutic applications of targeted regulation of microbial communities for obesity treatment.展开更多
摘要In December 2025,the White House released the National Security Strategy for Trump's second term.The United States shifted the focus of its national security strategy from external competition to internal restructuring—both within the United States and within the Western world.The goal was not to abandon the pursuit of global dominance but rather to repair the foundations of American hegemony in terms of power foundation,political ideology,and alliance management.It aims to forge a low-cost,selective,and transactional form of American hegemony.Compared to the National Security Strategies during the Biden administration and Trump's first term,the new report's narrative regarding China is relatively more measured.However,China remains viewed by the Trump administration as the most significant competitor.The United States will intensify its competition with China in economic and technological spheres,strengthen its military deterrence against China in the“Indo–Pacific”region,and exert pressure on China's influence in the Western Hemisphere and other regions.The Sino–US strategic competition is evolving into a new dynamic characterized by long-term competition,mutual balances,and selective engagement.China must analyze the complex implications of the Trump administration's strategic adjustments,enhance its capabilities,and refine its policy toolkit toward the United States.It is necessary to explore new models for“managed cooperation”between China and the United States.
基金supported by the National Natural Science Foundation of China,82471345(to LC)the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
摘要Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4uclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.
基金supported by grant from the National Natural Science Foundation of China(32222061 and 32301862)the Stra-tegic Priority Research Program of the Chinese Academy of Sciences(XDB0630102)the New Cornerstone Investigation Program(NCI202234)。
摘要Modern agriculture relies heavily on resource-intensive and environmentally harmful inputs,while the increasing global population and decreasing arable land demand new strategies to improve sustainable productivity of cereal crops,particularly reducing inorganic nitrogen fertilizer use while simultaneously increasing photosynthesis and grain yield in rice.To improve rice productivity,it is essential to improve photosynthetic nitrogen assimilation and optimize the translocation of carbon and nitrogen products from source to sink tissues.In this review,we first summarize recent advances in the genetic basis for improving grain yield by enhancing photosynthetic carbon and nitrogen assimilation.We then discuss progress in modulating the source-sink relationships to achieve higher yield and improved harvest index.Finally,we explore the necessary optimizations for adapting rice to high-density planting.These advancements are driving the development of sustainable green revolution varieties through the rational design of multi-gene pyramids and artificial intelligence-driven protein engineering.
摘要Against the backdrop of the accelerating global clean energy transition and the rapid increase in renewable energy source(RES)penetration,temporal imbalances between supply and demand in power systems are becoming increasingly prominent.Consequently,the phenomenon of negative electricity prices has evolved from sporadic occurrences into an increasingly prevalent market signal.This paper focuses on case studies of negative electricity prices in major international electricity markets(the Netherlands,Germany,Australia)and selected provincial markets in China(Shandong,Zhejiang).It systematically analyzes their underlying causal mechanisms,assesses their multidimensional impacts,and comparatively examines the mitigation strategies adopted across these diverse markets.The study reveals that the core driver of negative prices is the concentrated high generation feed-in from RES during low-load periods.This is concurrently influenced by multiple factors,including insufficient system flexibility,inter-zonal transmission congestion,and constraints imposed by specific market rules such as subsidies and bidding strategies.Major international electricity markets are widely exploring mitigation measures such as optimizing market clearing mechanisms,incentivizing energy storage and demand-side response,and adjusting subsidy policies.In contrast,the occurrence of negative prices in China’s electricity markets,while sharing common drivers,also exhibits complex correlations with domestic factors,notably medium-and long-term contracts and market power dynamics.Consequently,formulating and implementing differentiated and systematic mitigation strategies,drawing upon international experience while being tailored to China’s specific national context,is crucial for the long-term sustainable development of its electricity markets.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
摘要This paper examines Xinjiang's advantageous and characteristic agriculture from grain production functional zones,important agricultural product protection zones,characteristic agricultural product advantageous zones,hometowns of specialty products,One Village One Product,regional public brands,famous,special,premium,and novel agricultural products,characteristic agricultural products,agricultural product quality and safety,Taste of Xinjiang,Good Grain and Oil,and industrial clusters.Besides,from geographical indications,design patents(for packaging and containers),and trademarks,this paper studies the autonomous region's brand mark-related agricultural intellectual property.It also analyzes the main problems in the development of its brand agriculture,and puts forward suggestions such as building a diversified food supply system,improving the protection of geographical indication intellectual property rights,promoting the creation of design patents for packaging and containers,strengthening the registration of regional public trademarks and Madrid international trademarks,and carrying out targeted counterpart assistance to Xinjiang for characteristic agriculture.
基金financially supported by the National Natural Science Foundation of China(Grant No.52371014)Shenzhen Science and Technology Program(Grant No.JCYJ20230807091401004)the Fundamental Research Funds for the Central Universities(Grant No.20720230036)。
摘要Nickel-based superalloys(Ni-based superalloys)have attracted extensive attention in laser additive manufacturing(LAM)due to their capability to directly fabricate complex and high-performance structural components.However,the rapid melting and solidification inherent to LAM result in intense thermal cycling,which induces high residual stresses and microstructural heterogeneity within the fabricated parts.Among them,cracks,as the most destructive defects,can have a typical crack density of over five per mm2 without optimized processes.Moreover,the sudden failures of components caused by cracks account for more than 40%of the total failures of additively manufactured nickel-based superalloy components.They can rapidly expand along grain boundaries or brittle phases,significantly weakening the mechanical properties of components and causing sudden failures.To achieve highly reliable additive manufacturing components,it is essential to conduct in-depth research on the types,formation mechanisms of cracks in Ni-based superalloys,and their relationships with microstructure,residual stress,etc.This paper systematically reviews the crack characteristics and formation mechanisms of Ni-based superalloys during the laser additive manufacturing process,post-manufacturing,and service stages and comprehensively summarizes the current mainstream crack suppression strategies,specifically including process parameter optimization,residual stress regulation,alloy composition design,and subsequent post-treatment technologies,as well as incorporating emerging machine learning-assisted methods.The review aims to provide theoretical insights and technical guidance toward the development of crack-free Ni-based superalloy components fabricated by laser additive manufacturing.
基金supported by the National Key R&D Program of China(No.2021YFA0717800)National Natural Science Foundation of China(Nos.62475191,61835014,and 52327801).
摘要Ultraviolet(UV)nonlinear optical(NLO)crystals have received substantial interest in advanced laser technology.However,tailoring a UV NLO material with a large second harmonic generation(SHG)response and good UV transparency remains a challenge.Here,inspired by the classic A3-RE2-[BO3]3 parent template,two new rare-earth borate NLO crystals,RbNa2La2(BO3)3(RNLBO-Ⅰ)and Rb0.681Na2.319La2(BO3)3(RNLBO-Ⅱ),were extracted by merging larger ionic radius cations Rb+and La3+simultaneously using a chemical substitution-oriented strategy.As expected,both compounds achieve significant enhancements in SHG activities,reaching 4.5×and 4.3×KDP,respectively,exceeding three times that of the isomorphic Na3Gd2B3O9.Notably,RNLBO-Ⅰdisplayed the highest SHG response among alkali metal RE-borate NLO crystals containing isolated[BO3]groups in the short-wave UV region.Moreover,RNLBO-Ⅰand-Ⅱdemonstrated short UV cutoff edges at 213 and 207 nm,corresponding to wide bandgaps of 5.3 and 5.6 eV,respectively.Additionally,theoretical calculations and dipole moment analysis were conducted to clarify the origin of the enhanced SHG activities of RNLBO-Ⅰand-Ⅱ.The optimal balance between SHG intensity and UV transparency in RNLBO-Ⅰand-Ⅱunderscores their potential as UV NLO candidates and offers valuable insights for fabricating new advanced UV NLO materials.
基金Supported by SAFeCRAFT project jointly funded by Horizon Europe 101138411-SAFeCRAFT,and UKRI:10110519。
摘要To advance shipping decarbonization,hydrogen is increasingly recognized as a viable zero-carbon fuel.Currently,a hydrogen/diesel dual-fuel medium-speed engine represents an optimal prime mover for ships.However,challenges such as the large cylinder dimensions of marine medium-speed engines and the low temperatures at the combustion chamber walls can hinder efficient flame propagation,leading to the emission of unburnt hydrogen.This not only diminishes the engine's mechanical output but also poses significant safety risks.To address these issues,this study employs computational fluid dynamics(CFD)modelling to explore optimal diesel injection strategies that minimize unburnt hydrogen emissions in such engines.Specifically,this research examines the impacts of the diesel injection start angle,spray tilt angle,and injection duration on hydrogen combustion efficiency.The findings reveal that fine-tuning injection parameters substantially lower the fraction of unburned hydrogen.Adjusting the injection timing from 9.5°CA BTDC to 49.5°CA BTDC decreases the unburnt hydrogen fraction from 50%to 3%.Furthermore,modifying the spray tilt angle from 75.5°to 55.5°further decreases it to 2%,while shortening the injection duration from 35°CA to 34°CA achieves the lowest unburnt hydrogen fraction at just 1%.These results underscore the effectiveness of diesel injection strategies in optimizing the combustion in hydrogen/diesel dual-fuel marine medium-speed engines,offering a pathway for similar applications in the sector.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
摘要Traditional knowledge, biological genetic resources and folk literature and art are intellectual property rights of cultural heritage that can be shared by regional groups without time limit. This paper studies the traditional knowledge and cultural heritage of Xinjiang agriculture from the aspects of traditional knowledge, important agricultural heritage system, intangible cultural heritage, biological genetic resources, tangible cultural heritage, frontier development and defense culture, and cultural tourism resources. It analyzes the main problems existing in the protection and inheritance of them, and puts forward suggestions such as inheriting and sharing intellectual property rights of cultural heritage, improving the protection system of biological germplasm resources, establishing national-level cultural ecological protection (experimental) zones, promoting agricultural science and technology cultural exchanges, creating Xinjiang's characteristic Great Wall culture, deeply integrating "agriculture+culture+tourism", building national and autonomous region cultural parks, and dynamically inheriting agricultural cultural heritage.
基金financially supported by the National Natural Science Foundation of China(Grant No.32202158)Beijing-Tianjin-Hebei Fundamental Research Cooperation Project(Grant No.B2024202090)+1 种基金the CNPC Innovation Found(Grant No.2024DQ02-0311)the Haihe Laboratory of Sustainable Chemical Transformations(Grant No.24HHWCSS00009)for financial support on this work。
摘要The escalating issue of drug-resistant pathogens,largely driven by the overuse of conventional antibiotics,has become a significant global health threat.Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency,selectivity,and mild-operating conditions of natural enzymes is a promising approach but presents a significant challenge.Nanozymes—nanomaterials exhibiting enzyme-like catalytic activities—have emerged as innovative therapeutic platforms combining intrinsic antimicrobial properties with enhanced drug delivery capabilities.This review systematically elaborates on the concept,evolution,classification,and design synthesis strategy of antibacterial nanozymes,ranging from the nanoscale to the atomic scale,with a focus on their morphology,structure,catalytic activity,antimicrobial properties,stability,and reusability.It examines the antimicrobial mechanisms of nanozymes across three primary pathways:oxidative stress induction,metal ion release,and nonoxidative interactions,and further explores the synergistic outcomes enabled by their multimodal integration.It also evaluates the enhanced antibacterial effects achieved by nanozyme-antibiotic composites(NACs)—engineered hybrid systems that combine nanozymes with traditional antibiotics.Key synergistic mechanisms include increased reactive oxygen species(ROS)production alongside glutathione(GSH)depletion,enhanced antibiotic retention for controlled release,and membrane disruption to facilitate drug entry,resulting in a more potent"1+1>2"effect.Clinical applications of antibacterial nanozymes and NACs are also discussed,focusing on their potential to combat drug-resistant infections.Ultimately,the review identifies current research gaps and proposes future directions,highlighting the crucial role of these nanozyme-based therapies in advancing global efforts against drug-resistant infections.
基金supported by the National Natural Science Foundation of China(Nos.82374497 and 82174416)Special Topic Selected Independently by Wangjing Hospital of Chinese Academy of Traditional Chinese Medicine(No.WJYY-ZZXT-2023-16)Fundamental Research Funds for the Central Public Welfare Research Institutes(No.ZZ17-YQ-014).
摘要Muscle and bone,key tissues that maintain the body’s structure and function,are closely connected via mechanical and biochemical interactions.The vascular system plays a crucial role in musculoskeletal health,not only by providing nutrients and oxygen but also by regulating growth,regeneration,and metabolism.This review systematically examines the vascular structure and function of the musculoskeletal system,and explores the complex biochemical signaling networks involving myokines,osteokines,and vascular‑derived factors.Vascular dysfunction is a key contributor to the pathogenesis of degenerative diseases like sarcopenia(SP)and osteoporosis(OP),making vascular‑targeted therapies a promising approach for their treatment.Potential strategies for restoring vascular health include molecular targeting,exercise training,nutritional supplementation,cardiovascular pharmacotherapy,hormone therapies,and tissue engineering—all of which may help slow aging‑related musculoskeletal degeneration.Despite significant research progress,challenges remain in the clinical translation of these interventions.Future research should focus on elucidating the molecular mechanisms of muscle‑bone‑vascular interactions and exploring innovative tissue engineering techniques.This review provides a comprehensive understanding of the dynamic interactions between muscle,bone,and vascular systems,highlighting the importance of vascular health in musculoskeletal disease management,and proposes novel vascular‑targeted approaches for the prevention and treatment of musculoskeletal disorders.
基金supported by the Key Research and Development Program of Anhui ProvinceChina(2023h11020006 and 2023n06020006)+2 种基金the National Natural Science Foundation of China(32301738)the Science and Technology Innovation and Breakthrough Plan Program of Anhui Province,China(202423m10050002)the Jianghuai Granary Program,China(2026YL009)。
摘要Highlights Os GATA15 plays an important role in regulating the growth and development of the rice fiag leaf.The small flag leaf restorer line NP27 offers a novel breeding strategy and germplasm resource for hybrid rice seed production without leaf-cutting.Rice is one of the main food crops globally.With the continuous increase in population and the decrease in effective arable land area,increasing rice yield is necessary to ensure the food supply(Wing et al.2018).
基金the support of the National Natural Science Foundation of China(22208161)the Metasequoia Faculty Start-up Research Fund of Nanjing Forestry University(163105163)NSERC Canada。
摘要Lignin is a major by-product of industries such as pulping and biomass refining.However,currently,its high-value utilization rate remains extremely low.Owing to its high carbon content and unique natural aromatic structure,lignin serves as an ideal biomass-derived precursor for preparing porous carbon electrodes for supercapacitors.Existing relevant reviews are lacking in systematic correlation analysis between the characteristics of lignin precursors and the structural evolution of carbon materials,as well as the systematic sorting of their performance enhancement technologies.Centering on the multi-scale structural engineering of lignin-derived porous carbon electrodes,this review systematically summarizes the key technological advancements in improving their supercapacitive performance.It emphasizes elaborating on the structural and performance differences of porous carbons derived from four types of industrial lignin(lignosulfonate,enzymatic hydrolysis lignin,alkali lignin,and organosolv lignin),as well as the research status and regulation mechanisms of three core technologies,including pore structure regulation,surface modification,and composite strategies.Meanwhile,the current core challenges in this field,such as raw material consistency,the balance between pore structure and conductivity,large-scale production,and the standardization of performance evaluation,are analyzed,and four targeted future development directions are proposed:green synthesis approaches,intelligent structural design,device integration,and full life cycle assessment.This review aims to provide theoretical insights and technical references for the design of high-performance lignin-based supercapacitor electrode materials,thereby promoting the efficient,sustainable,and high-value utilization of industrial lignin resources.
基金National Natural Science Foundation of China(52472132)Opening Project of Engineering Research Center of Eco-friendly Polymeric Materials,Ministry of Education(EFP-KF2403)Innovation Service Capability Support Plan of Xianyang(Science and Technology Innovation Talents)。
摘要Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr0.2Ti0.8O3-0.9Ba0.7Ca0.3TiO3)ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L3H7 configuration achieving an open circuit voltage(VOC)of 23.13 V and a short circuit current(ISC)of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
摘要This paper introduces the current development status of new quality productive forces in agriculture,animal husbandry,and aquaculture in Xinjiang.It studies the development momentum of the seed industry in the autonomous region from aspects,including seed industry array-type enterprises,breeding and seed production bases,crop varieties,and seed production and operation.It also explores the current situation of intellectual property rights related to scientific and technological innovation in Xinjiang,covering new varieties of agricultural plants,forest and grass plants,livestock and poultry,bees,silkworms,and aquatic animals and plants,as well as invention patents,utility model patents,and design patents for the product itself.Based on an analysis of the main problems facing its new quality productive forces and sci-tech innovation,recommendations are put forward,including managing the agricultural ecological environment according to local conditions,developing facility agriculture and smart agriculture,strengthening the purification and rejuvenation of traditional varieties and the introduction and acclimatization of new varieties,cultivating varieties with independent intellectual property rights,protecting invention patents and utility model patents,creating design patents for the product itself,and empowering the development of agricultural new quality productive forces.
基金supported by the National Natural Science Foundation of China(Grant Nos.32160501 and 32201901)the Accelerated Breeding Initiative of the Consultative Group on International Agricultural Research(Grant No.INIT-01)+2 种基金the Natural Science Foundation of Guangxi,China(Grant No.2021GXNSFAA220026)the Program on National Modern Agricultural Technology System Guangxi Innovation Team,China(Grant No.nycytxgxcxtd-2021-01-04)the Advantage Team Project of Guangxi Academy of Agricultural Sciences,China(Grant No.2026YT070).
摘要Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence conditions that occur during flooding,particularly at the germination and vegetative stages.Anaerobic environments hinder seedling establishment during germination,while prolonged submergence during the vegetative stage impairs growth,ultimately reducing yield and grain quality.These stresses,driven by extended inundation,trigger a cascade of detrimental physiological responses and represent a major barrier to stable rice production and global food security.In this review,we examine the effects of flooding on rice growth at both the germination and vegetative stages.We further summarize recent advances in the identification of flooding-tolerant germplasm,QTL mapping,genome-wide association study,transcriptomic and proteomic analyses,and other molecular studies.Subsequently,we highlight potential cultivation and regulatory strategies,including genetic,morphological,physiological,and endogenous hormone-related approaches,aimed at enhancing tolerance to anaerobic and submergence stress.Together,these approaches underscore the promise of integrating molecular insights with agronomic practices to mitigate flooding damage and support sustainable rice production.
基金supported in part by the National Natural Science Foundation of China(12171124,12471416)the Natural Science Foundation of Heilongjiang Province of China(PL2024F015)+2 种基金the MCIN/AEI/10.13039/501100011033“ERDF a Way of Making Europe”(PID2021-124486NB-I00)the Alexander von Humboldt Foundation of Germany。
摘要This paper addresses the protection-strategy-based distributed state estimation(SE)problem for time-varying nonlinear complex networks,where uncertain inner coupling and random false data injection attacks are considered.Owing to the fact that the measurement signals can be easily injected with false data by potential attackers before being transmitted to the estimator,a novel protection strategy is firstly proposed from the perspective of the defender to mitigate the effects of malicious attacks on the estimation performance.Based on the proposed protection strategy,more suspicious and unreliable measurements received are identified and discarded respectively.Accordingly,the zero-order holder strategy is employed to compensate for the discarded measurements.Subsequently,the purpose of this paper is to design a protection-strategy-based distributed SE scheme such that an optimized upper bound(UB)on the estimation error covariance(EEC)is obtained.Furthermore,a sufficient criterion is provided to guarantee the uniform boundedness of UB on the EEC.Finally,a localization problem involving multiple mobile robots is used to demonstrate the effectiveness and practicality of proposed variance-constrained optimized SE method.
基金National Natural Science Foundation of China,Grant/Award Number:81970874National Key Research and Development Program of China,Grant/Award Number:2023YFC2306500,21SG39 and 24520712900。
摘要Cochleovestibular impairment is a debilitating sequela of oncological intervention,resulting from multifaceted organic damage to the inner ear.Clinically manifesting as sensorineural hearing loss and vestibular dysfunction,ototoxicity significantly compromises cognitive health and long-term quality of life.Despite its prevalence,early detection and prophylactic intervention remain clinically suboptimal.This review provides a comprehensive analysis of the molecular pathogenesis and risk factors—including age,specific genetic polymorphisms,and cumulative dosage—associated with various cancer modalities such as platinum-based chemotherapy,radiotherapy,and emerging immunotherapies.We specifically evaluate the cellular mechanisms of cisplatin-induced irreversible damage to the stria vascularis and hair cells.Furthermore,this article critiques current clinical monitoring protocols,advocating for the integration of baseline audiological screening and high-frequency auditory assessments as mandatory standards of care.Finally,we synthesize the current therapeutic landscape,ranging from established otoprotective agents and cochlear implants to novel candidate drugs in the preclinical pipeline.By bridging mechanistic research with translational evidence,this review emphasizes a precision-medicine approach to balance therapeutic efficacy with the preservation of auditory integrity for cancer survivors.
基金supported by the Key Program of Natural Science Foundation of Tianjin(Grant No.21JCZDJC00770)the Tianjin Metrology Technology Project(Grant No.2024TJMT049).
摘要The traditional method of performance degradation prediction and maintenance of rolling bearings only considers a single sensor signal,which makes it difficult to automatically partition degradation stages and prone to over-detection.A new method of performance degradation evaluation and maintenance of rolling bearings based on data-level fusion,adaptive health state partitioning,and state maintenance is proposed.Firstly,considering the degradation and impact in the process of bearing deterioration,the multi-sensor signals are dynamically weighted to achieve data-level fusion.Secondly,a bearing health index was established based on fast spectral correlation,Wasserstein distance,and linear rectification techniques.On this basis,by combining the Bayesian information criterion and the elbow rule,the precise division of rolling bearing health state is realized through hidden Markov model regression.Then,random forest was used to classify and predict the data to verify the validity of the proposed data fusion method and health indicator.Finally,condition-based maintenance strategy based on the fourth moment,stress-strength interference model,and Gamma process is proposed to avoid excessive detection and reduce maintenance costs.Through accelerated degradation experiments and field validation tests on the rolling bearing test data set of Xi’an Jiaotong University and FEMTO(PRONOSTIA),the accuracy and superiority of the proposed method in the prediction and maintenance of bearing health state are verified.
基金supported by the Key R&D Program of Guangdong Province(2022B0202020004)the National Natural Science Foundation of China(32202064)+1 种基金the Natural Science Foundation of Jiangxi Province(20224BAB215044)the China Postdoctoral Science Foundation(2021M701547)。
摘要The global rise in obesity and its associated metabolic syndrome has garnered significant attention in recent years.Targeting the gut microbiota has been proposed as a promising strategy for the treatment of obesity and its related metabolic disorders.Bifidobacterium,one of the typical intestinal microorganisms in healthy individuals,has been recognized for its beneficial role in maintaining overall health.Numerous animal and human studies have elucidated the beneficial impact of bifidobacteria in maintaining the physiological and metabolic well-being of the host.Previous studies have found that bifidobacteria play a crucial role in regulating intestinal microbial communities and metabolism,as well as alleviating obesity by managing appetite,improving insulin resistance,modulating cholesterol and lipid metabolism,reshaping immune marker levels,and reducing inflammation.However,there remains a lack of comprehensive exploration into the potential correlation between bifidobacteria and obesity.By exploring the link between bifidobacteria and obesity based on recent research,this review aims to provide a theoretical foundation for elucidating the fundamental mechanisms underlying probiotic bifidobacteria intervention and promote the therapeutic applications of targeted regulation of microbial communities for obesity treatment.