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Study on Acute Toxicity of Purified Protein HAS1 Expression in KM Mice 认领 引用 被引量：1
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作者 Guoru XIONG Gengfeng ZHAO +2 位作者 Jungang WANG Guilan XING Shuzhen ZHANG 《Agricultural Biotechnology》 2019年第4期69-71,共3页
[Objectives]The antifungal protein HAS1 newly obtained was evaluated for acute toxicity safety in KM mice according to relevant national regulations,so as to eliminate people s concerns about the safety of transgenic ... [Objectives]The antifungal protein HAS1 newly obtained was evaluated for acute toxicity safety in KM mice according to relevant national regulations,so as to eliminate people s concerns about the safety of transgenic plants.[Methods]The acute toxicity of the purified protein HAS1 was observed by intragastric administration of mice,and the poisoning symptoms,poisoning degree,recovery and death were observed.[Results]No abnormal toxicity symptoms were observed in the test group,the vehicle control group and the blank control group.The main tissues and organs were not abnormal in gross anatomy.The average body weight of each group showed an increasing trend compared with before administration at 1,3,7,11 and 14 d after administration.It was found that after giving the purified protein HAS1 to KM mice at a cumulative dose of 64 mg/kg a day,no obvious toxicity was observed in the acute toxicity test,indicating that the test substance was non-toxic by oral administration.[Conclusions]This study provides a basis for further use of the protein and its coding genes. 展开更多
关键词 Bacillus subtilis HAS Purified protein HAS1 KM mice Toxic reaction
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Skin Anaphylaxis Test of Purified Protein HAS1 in Cavies 认领 引用
2
作者 Guoru XIONG Gengfeng ZHAO +2 位作者 Jungang WANG Guilan XING Shuzhen ZHANG 《Agricultural Biotechnology》 2019年第5期73-75,共3页
The antifungal protein HAS1 is a new antifungal protein isolated from the genome of Bacillus subtilis HAS,which has a good inhibitory effect on various pathogenic fungi in sugarcane.This study aimed at evaluating the ... The antifungal protein HAS1 is a new antifungal protein isolated from the genome of Bacillus subtilis HAS,which has a good inhibitory effect on various pathogenic fungi in sugarcane.This study aimed at evaluating the immunological transfer reaction of the test sample through repeated skin contact by observing whether the cavy skin repeatedly exposed to purified protein HAS1 suffers from allergic reaction and how strong is the allergic reaction.The results showed that the test group and the vehicle control group exhibited no allergic reaction in the skin immediately and at 24,48 and 72 h and had an mean reaction score and a sensitization rate both of 0,so the results of the naked eye observation were both nonallergenic to cavy skin;and in the positive control group,the cavies were observed to be highly sensitized immediately after removing the drug,mildly sensitized at 24 h,and not sensitized at 48 and 72 h,which meant the skin allergy was alleviated with the observation time.It is suggested that the purified protein HAS1 is negative for cavy skin anaphylaxis test(nonallergenic to cavy skin),which provides an experimental basis for further utilization of the protein and its coding gene. 展开更多
关键词 Saccharum officinarum L. Bacillus subtilis HAS Purified protein HAS1 Cavies Anaphylaxis
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透明质酸合酶1在胃癌组织中的表达及其与胃癌根治术术后患者预后的关系 认领 引用 被引量：1
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作者 努热丽亚·阿布力克木 孙萍萍 +3 位作者 张筱静 陆冰 凯迪尓耶·阿卜杜萨拉木 黄剑飞 《中华消化杂志》 CAS CSCD 北大核心 2022年第2期123-126,共4页
通过分析透明质酸合酶1(HAS1)在胃癌组织中的表达及其与胃癌患者术后预后的关系,发现HAS1在胃癌组织中的表达水平高于正常胃黏膜组织。胃癌组织中HAS1表达水平与TNM分期有关,Kaplan-Meier生存分析显示HAS1高表达的患者预后更差。单因素... 通过分析透明质酸合酶1(HAS1)在胃癌组织中的表达及其与胃癌患者术后预后的关系,发现HAS1在胃癌组织中的表达水平高于正常胃黏膜组织。胃癌组织中HAS1表达水平与TNM分期有关,Kaplan-Meier生存分析显示HAS1高表达的患者预后更差。单因素和多因素分析显示,HAS1表达、TNM分期是影响胃癌患者预后的独立危险因素。HAS1关联蛋白质分析发现,HAS1与透明质酸酶1、透明质酸酶2、CD44、透明质酸酶4、精子黏附分子1、肌球蛋白重链10、细胞迁移诱导透明质酸酶1、胶质透明质酸结合蛋白、尿苷二磷酸-葡萄糖脱氢酶、KY蛋白存在相互作用,提示这些蛋白质可能在胃癌的进展中存在内在联系。在胃癌发生、发展中,HAS1可以作为胃癌患者预后的分子标志物和治疗的潜在靶点。 展开更多
关键词 胃肿瘤 HAS1蛋白 免疫组织化学 预后
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