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A numerical study of hemodynamic effects on arteriovenous fistula calcification 认领 引用
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作者 Zhe Wang Huihui Ning +4 位作者 Lihua Wang Yaohong Wang Dekui Yuan Hewen Li Yingxue Lv 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第1期344-354,共11页
Arteriovenous fistula(AVF)calcification is a common complication in hemodialysis patients that leads to AVF dysfunction and decreases the AVF survival,but the mechanisms of AVF calcification,especially the role of hem... Arteriovenous fistula(AVF)calcification is a common complication in hemodialysis patients that leads to AVF dysfunction and decreases the AVF survival,but the mechanisms of AVF calcification,especially the role of hemodynamic changes in AVF calcification have not been fully investigated.In this study,a computational fluid dynamics(CFD)model was carried out based on AVF,at the distal anastomosis of the cephalic vein and radial artery,generated from a patient-specific computed tomography(CT)angiography and Doppler ultrasound image.Hemodynamic factors were considered to explore the mechanisms responsible for the initiation and progression of AVF calcification.Five stages in one cardiac cycle were chosen to be studied for the velocity field,pressure,time-averaged wall shear stress(TAWSS),and oscillatory shear index(OSI).Blood pressure was higher in the arteriovenous anastomosis,and variations of great amplitude of pressure were examined during the cardiac cycle.Blood pressure,transient shear stress,TAWSS,and OSI were higher in the arteriovenous anastomosis and at the bottom of expanded outflow vein,and these sites were highly consistent with the calcified areas shown on CT angiography.On the contrary,no calcification was found in sites where streamline was stable,blood pressure did not change dramatically,as well as TAWSS and OSI were lower.It was shown that AVF calcification was correlated with hemodynamic changes,which may contribute to further understanding the mechanisms of AVF calcification and providing scientific evidence to inform the optimization of surgical strategies and the development of personalized interventional measures in clinical contexts. 展开更多
关键词 Arteriovenous fistula Vascular calcification Hemodynamics Wall shear stress Oscillatory shear index
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Mimicry of whole-body blood circulation through genetic algorithm in reduced-order hemodynamic model 认领 引用
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作者 Minghao Liao Taoping Bai +2 位作者 Ming Zhang Zhongyou Li Wentao Jiang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第3期1-14,共14页
Physics-based reduced-order hemodynamic models have garnered significant interest because of their ability to capture whole-body cardiovascular fluctuations.However,coordinating the numerous interdependent parameters ... Physics-based reduced-order hemodynamic models have garnered significant interest because of their ability to capture whole-body cardiovascular fluctuations.However,coordinating the numerous interdependent parameters within these models remains a long-standing challenge,and the demand for the personalization of these models persists.We constructed a complex whole-body model of blood circulation(containing the heart,arterial trunk,and branches)and utilized genetic algorithms to automatically and efficiently coordinate the model parameters.Additionally,we introduced a“pseudo-distance”metric by updating the derivative dynamic time-warping algorithm to evaluate the similarity between the simulated waveforms and the target waveforms.After 40 rapid iterations,a complete match was achieved with the target in terms of the blood pressure and flow waveforms amplitude as well as the time domain,resulting in highly realistic waveform mimicry(i.e.,the pseudo-distance approached zero).This model takes about 40 min,far less than the manual modeling that usually takes several months.These results indicate that GAs significantly improve the modeling efficiency of reduced-order models,thus lowering the user threshold. 展开更多
关键词 Reduced-order model Genetic algorithm Hemodynamics Cardiovascular Pseudo-distance
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Advances in understanding cold-related hemodynamic changes in the cardiovascular system 认领 引用
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作者 Pengyan Wu Ye Wang +2 位作者 Zeng Wang Bo Yu Shaohong Fang 《Frigid Zone Medicine》 2026年第1期49-55,共7页
Cold exposure induces significant hemodynamic disturbances that contribute to increased morbidity and mortality from cardiovascular disease(CVD).This review explores the physiological and molecular mechanisms by which... Cold exposure induces significant hemodynamic disturbances that contribute to increased morbidity and mortality from cardiovascular disease(CVD).This review explores the physiological and molecular mechanisms by which cold stress affects blood pressure regulation,vascular resistance,and wall shear stress(WSS),and how these alterations promote CVD development.Cold exposure elevates blood pressure primarily through activation of the sympathetic nervous system(SNS)and the renin-angiotensin-aldosterone system(RAAS).These neurohumoral pathways enhance vasoconstriction and increase blood viscosity,thereby elevating peripheral vascular resistance.Moreover,cold-induced alterations in WSS impair endothelial function,facilitate platelet aggregation,and accelerate atherosclerotic progression.Despite extensive evidence linking cold exposure to hemodynamic and vascular dysfunction,the precise molecular and integrative mechanisms remain incompletely understood.We propose that the SNS-RAAS axis represents a central regulatory pathway underlying cold-induced hemodynamic changes,warranting further investigation to clarify its contribution to cold-related cardiovascular pathology. 展开更多
关键词 cold hemodynamics blood pressure blood resistance blood shear stress
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Letter to the Editor:Hemodynamic role in hepatic encephalopathy pathogenesis following transjugular intrahepatic portosystemic shunt placement 认领 引用
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作者 John Halphen Jr Yash S Dayal +3 位作者 Cameron Laurie Mohadese Ahmadzade David Wynne Mohammad Ghasemi-Rad 《World Journal of Radiology》 2026年第6期86-90,共5页
Hepatic encephalopathy(HE)is a common complication following transjugular intrahepatic portosystemic shunt(TIPS)placement and is thought to result from reduced hepatic detoxification of neurotoxins.However,Zhuang et a... Hepatic encephalopathy(HE)is a common complication following transjugular intrahepatic portosystemic shunt(TIPS)placement and is thought to result from reduced hepatic detoxification of neurotoxins.However,Zhuang et al in the World Journal of Radiology demonstrate that this understanding may be incomplete through exploration of the pathophysiology from a hemodynamic perspective.They found significant changes in cerebral blood flow(CBF)and spontaneous brain activity following TIPS.Initially,CBF increased in specific areas within the first month,followed by a return to baseline at three months.These CBF changes coincided with increased spontaneous brain activity that persisted in some areas,suggesting compensation for functional loss in other regions.Together with the fact that serum ammonia remained unchanged in this cohort and prior work showing that,after three months,HE risk returns to pre-TIPS levels,these results suggest that HE may develop in individuals susceptible to these hemodynamic and adaptive changes,warranting further research. 展开更多
关键词 Arterial spin labeling Cerebral blood flow Hemodynamics Hepatic encephalopathy Digit symbol substitution test Resting-state functional magnetic resonance imaging Transjugular intrahepatic portosystemic shunt
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Comparison of propofol alone vs propofol-phenylephrine combination for intraoperative hemodynamic stability in glioma surgery 认领 引用
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作者 Rhea Thotungal Ashutosh Kaushal +4 位作者 Amit Agrawal Anuj Jain Vaishali Waindeskar Rudrashish Haldar Pfokreni Lokho 《World Journal of Methodology》 2026年第3期270-277,共8页
BACKGROUND Propofol is widely used for induction in glioma surgery for its neuroprotective effects and favorable recovery profile.However,its dose-dependent hypotension is a major limitation in procedures requiring st... BACKGROUND Propofol is widely used for induction in glioma surgery for its neuroprotective effects and favorable recovery profile.However,its dose-dependent hypotension is a major limitation in procedures requiring stable cerebral perfusion.AIM To compare the efficacy of propofol vs propofol-phenylephrine(PPE)combination in maintaining hemodynamic stability in patients undergoing glioma surgery.METHODS Ninety American Society of Anesthesiologists I-II patients scheduled for elective glioma surgery were randomized to receive either propofol(group P)or a PPE admixture(group PPE).Induction was performed with slow titration of the study drug until loss of verbal response and Bispectral index<60,followed by a continuous infusion(50μg/kg/minute)until skin closure.Hemodynamic parameters[mean arterial pressure(MAP),systolic blood pressure,diastolic blood pressure,and heart rate]were recorded at baseline,during induction,immediately after intubation,and at predefined intraoperative time points.The incidence of hypotension,vasopressor and esmolol use,and brain relaxation scores were compared.RESULTS Group PPE demonstrated significantly better preservation of MAP,systolic blood pressure,diastolic blood pressure,and heart rate throughout the peri-induction and intraoperative periods(P<0.05).The mean maximum MAP reduction during induction was greater in group P compared with group PPE(19.7 mmHg vs 12.5 mmHg;P<0.01).Hypotensive episodes were significantly more frequent in group P than in group PPE(84.4%vs 6.7%;P<0.001).Rescue phenylephrine requirements were markedly lower in group PPE(P<0.001).Esmolol use and brain relaxation scores were comparable between groups.CONCLUSION Adding phenylephrine to propofol for induction and maintenance provides superior hemodynamic stability without compromising brain relaxation in glioma surgery. 展开更多
关键词 Propofol Phenylephrine Hemodynamic stability Glioma surgery Induction of anesthesia Neuroanesthesia Brain relaxation
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Application Research on Hemodynamic and Metabolic Abnormalities in Patients with Subclinical Hypothyroidism 认领 引用
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作者 Juan Luo Jiaqi Chen +1 位作者 Jingfeng Li Nengwen Lin 《Journal of Clinical and Nursing Research》 2026年第6期35-40,共6页
Objective:To explore the clinical application value of abnormal hemodynamic and metabolic indicators in patients with subclinical hypothyroidism(SCH),and to provide clinical evidence for early intervention of SCH and ... Objective:To explore the clinical application value of abnormal hemodynamic and metabolic indicators in patients with subclinical hypothyroidism(SCH),and to provide clinical evidence for early intervention of SCH and prevention of cardiovascular complications.Methods:A total of 40 SCH patients were enrolled as the study group(Group 1),and another 40 subjects with normal thyroid function were selected as the control group(Group 0).General clinical data(gender,age,height,weight)and hemodynamic indicators(epicardial adipose tissue thickness,aortic pulse wave velocity,carotid intima-media thickness)were collected,respectively.The differences of each indicator between the two groups were compared,and the correlation among indicators was analyzed by statistical methods.Results:The thickness of epicardial adipose tissue and carotid intima-media thickness in the study group were significantly higher than those in the control group(p<0.05),while the aortic pulse wave velocity was significantly lower(p<0.05).The body mass index(BMI)of the study group was higher than that of the control group,with more middle-aged and older adults and a higher female proportion.Conclusion:SCH patients present obvious hemodynamic disturbance and metabolic imbalance.Epicardial adipose tissue thickness,aortic pulse wave velocity,and carotid intima-media thickness can be used as indicators to evaluate cardiovascular risk in SCH patients.Early monitoring and intervention of the above indicators are beneficial for improving patients’prognosis. 展开更多
关键词 Subclinical hypothyroidism Hemodynamics Metabolic abnormalities
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Abnormal invasive hemodynamics in heart transplant recipients:A single-center,retrospective study 认领 引用 被引量：1
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作者 Navin Rajagopalan Donna R Dennis +1 位作者 Julia Akhtarekhavari Kenneth Campbell 《World Journal of Transplantation》 2025年第3期148-156,共9页
BACKGROUND Few studies have quantified invasive hemodynamic parameters in post heart transplant recipients.AIM To report the incidence of abnormal hemodynamics in heart transplant recipients at 1-year and 3-year post-... BACKGROUND Few studies have quantified invasive hemodynamic parameters in post heart transplant recipients.AIM To report the incidence of abnormal hemodynamics in heart transplant recipients at 1-year and 3-year post-transplant and determine if there was any correlation with recipient and donor characteristics.METHODS Data from 279 consecutive heart transplant recipients from 2007 through 2020 were analyzed.Clinical variables regarding both recipients and donors as well as hemodynamic variables obtained via right heart catheterization during 1-year and 3-year annual testing were recorded.Simple and multiple linear regression tests were used to determine how recipient and donor variables influenced hemodynamic parameters at 1-year and 3-year.RESULTS Data were available for 260 patients and 224 patients at 1-year and 3-year posttransplant respectively.At 1-year,abnormal hemodynamic parameters were common with 24%patients having right atrial pressure(RAP)>10 mmHg,52%with mean pulmonary artery pressure>20 mmHg,and 12%with pulmonary capillary wedge pressure(PCWP)>18 mmHg.Similar abnormalities were noted at 3-year post-transplant.Recipient body mass index(BMI)demonstrated the strongest correlation with all 3 variables at both 1-year and 3-year by multivariate linear regression analysis(P<0.001 for both).Both donor age and predicted heart mass difference between recipient and donor were significantly linked to RAP and PCWP at 1-year but did not predict any variables at 3-year post-transplant.CONCLUSION Abnormal hemodynamics are common at 1-year and 3-year post-transplant and are associated with recipients with high BMI. 展开更多
关键词 Heart transplantation Right heart catheterization Obesity Heart failure Hemodynamics
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Liver and systemic hemodynamics in cirrhotic children 认领 引用
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作者 Roberto Tambucci Xavier Stephenne +1 位作者 Aniss Channaoui Catherine de Magnée 《World Journal of Hepatology》 2025年第7期18-29,共12页
Portal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in the adult population.During cirrhosis progression,circulation becomes hyperdynamic,with cardiac,p... Portal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in the adult population.During cirrhosis progression,circulation becomes hyperdynamic,with cardiac,pulmonary and renal consequences.Cirrhotic adults also present with cirrhotic cardiomyopathy,with systolic and diastolic dysfunction and electrophysiological abnormalities.This article provides an update on normal liver hemodynamics,a brief reminder of the liver and systemic hemodynamics in cirrhotic adults,and a description of liver and systemic hemodynamics in cirrhotic children.This review attempts to clarify whether liver and systemic hemodynamics are altered in cirrhotic children like they are in adults.The characterization of these hemodynamic disturbances could contribute to a better understanding of hepatic and systemic physiopathology in pediatric cirrhosis. 展开更多
关键词 Cirrhosis Children Portal hypertension Liver hemodynamics Systemic hemodynamics Cirrhotic cardiomyopathy
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Neuropsychiatric symptoms in the context of hemodynamic disruption during septic shock 认领 引用 被引量：1
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作者 Hai-Ning Li Jia-Lin Wang Wei Chen 《World Journal of Psychiatry》 SCIE 2025年第7期135-144,共10页
BACKGROUND Septic shock represents one of the most severe critical illness types,characterized by significant hemodynamic disorders and neuropsychiatric symptoms.This study aimed to investigate the association mechani... BACKGROUND Septic shock represents one of the most severe critical illness types,characterized by significant hemodynamic disorders and neuropsychiatric symptoms.This study aimed to investigate the association mechanism between hemodynamic indicators and neuropsychiatric symptoms in patients with septic shock,revealing potential pathophysiological connections.AIM To investigate the link between hemodynamic parameters and neuropsychiatric symptoms in septic shock.METHODS A retrospective case-control study involving 132 patients with septic shock.Multiple assessment tools were employed,including the Confusion Assessment Method,Hospital Anxiety and Depression Scale,Posttraumatic Stress Disorder Scale,and Mini-Mental State Examination,systematically evaluating patients’neuropsychiatric symptoms and hemodynamic indicators.RESULTS Patient mean age was 52.4±12.3 years,with 68.5%males.Multivariate analysis revealed significant correlations between neuropsychiatric symptom severity and mean arterial pressure4 mmol/L(OR=3.1),and elevated interleukin-6 inflammatory factors(OR=2.4).Neuropsychiatric symptom incidence rates were:Delirium 37.1%;anxiety 28.8%;depression 24.2%;and posttraumatic stress disorder 19.7%.CONCLUSION Hemodynamic disorders in patients with septic shock are closely associated with neuropsychiatric symptoms,influencing central nervous system function through complex inflammatory and neurotransmitter pathways. 展开更多
关键词 Septic shock Hemodynamics Neuropsychiatric symptoms Delirium
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Hemodynamic Profile Based on Right Heart Catheterization in AdultAcyanotic Congenital Heart Disease with Pulmonary Hypertension 认领 引用
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作者 Dina Anggraini Kurnia Wahyudi +2 位作者 Melawati Hasan Sri Endah Rahayuningsih Charlotte Johanna Cool 《Congenital Heart Disease》 SCIE 2025年第2期133-141,共9页
Background:Congenital heart disease(CHD)occurs in 9out of 100 births and is the leadingcatuse of birth defects,with acyanotic CHD being more common.The incidence of adult CHD is risingfaster than pediatric CHD.Pulmona... Background:Congenital heart disease(CHD)occurs in 9out of 100 births and is the leadingcatuse of birth defects,with acyanotic CHD being more common.The incidence of adult CHD is risingfaster than pediatric CHD.Pulmonary hypertension is the most common complication in untreated CHDpatients.Methods:This study is retrospective descriptive research based on medical record data andthe results of right heart catheterization exanninations in adult acyanotic CHD aged>18 years and freefrom other organ disorders.Results:A total of 103 patients met the inclusion criteria,the majority wereyoung adults and predominantly fernale.The median height of 155.0 cm(IQR:150.0-160.0),the meanweight was 49.6 kg±10.7 kg,and BSA of 1.4 m2±0.1 m2.Most patients had a normal BMI status andwere classified as WHO-FC II.Herodynamic findings included a median PARI of 13.5 WU/m2(IQR4.5-29.6),RAP 7.0 mmHg(IQR:5.0-11.0),mPAP 56.0 mmHg±23.5 mmHg,LVEDP 9.5 mmHg±3.9 mmHg,PVR 12.6 WU±11.0 WU,PVR/SVR 0.5 WU±0.4 WU,pulmonary artery saturation 74.0%±12.1%,aorticsaturation 88.1%±7.8%,mixed venous saturation 59.0%±10.1%.Conclusions:This study providescomprehensive data on the demographic characteristics and henodynamic parameters of patients withCHD and pulmonary hypertension.As a hospital-based registry,this study offers valuable insights into theclinical profile of adult CHDpatients at Dr.Hasan Sadikin GeneralHospital,Bandung,. 展开更多
关键词 Adult congenital heart disease acyanotic pulmonary hypertension hemodynamic
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Association Between Blood Biomarkers and Hemodynamic Parameters in Adolescents and Adults After the Fontan Procedure:A Retrospective Cohort Study 认领 引用
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作者 Kentaro Kogawa Daishi Hirano +3 位作者 Yuka Okawa Emi Kittaka Shunsuke Baba Reiji Ito 《Congenital Heart Disease》 SCIE 2025年第6期659-671,共13页
Background:An increasing number of patients with Fontan circulation are reaching adulthood;however,long-term outcomes remain limited by Fontan failure,which is characterized by elevated central venous pressure(CVP)and... Background:An increasing number of patients with Fontan circulation are reaching adulthood;however,long-term outcomes remain limited by Fontan failure,which is characterized by elevated central venous pressure(CVP)and reduced cardiac output.Red blood cell distribution width(RDW),a readily available hematological parameter,is a known prognostic marker of heart failure.However,its relationship with invasive hemodynamics in adolescent and adult Fontan patients has not been fully examined.Objectives:To clarify the association between RDW and invasive hemodynamic indices in adolescent and adult Fontan patients and assess the utility of RDW as a noninvasive circulatory marker.Methods:This single-center retrospective study included consecutive Fontan patients aged≥16 years who underwent routine cardiac catheterization≥5 years after surgery,between June 2014 and July 2025.Laboratory data and catheter-derived hemodynamics were also analyzed.The primary endpoint was the correlation between RDW and CVP,and the secondary endpoint was the correlation between RDW and central venous oxygen saturation(ScvO2).Results:Forty patients(median age:22 years)were analyzed.The median RDW was 13.3%,and the median CVP was 11.0 mmHg.RDW correlated positively with CVP(ρ=0.57,p14.5%)had higher CVP(14.5 vs.10.5 mmHg,p<0.001)and lower ScvO2(63.8%vs.76.1%,p<0.001),compared with those with normal RDW.Multivariable analysis identified RDW as an independent predictor of ScvO2(p<0.001).Conclusions:In adolescents and adults after the Fontan procedure,RDW was significantly associated with elevated CVP and reduced ScvO2and independently predicted impaired oxygen delivery.RDW is inexpensive,widely accessible,and may serve as a practical noninvasive biomarker for the early detection of Fontan failure and the optimization of invasive testing and interventions during long-term follow-up. 展开更多
关键词 Biological markers central venous pressure erythrocyte indices fontan procedure hemodynamics oxygen saturation
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Numerical Study on Hemodynamic Characteristics and Distribution of Oxygenated Flow Associated with Cannulation Strategies in Veno-Arterial Extracorporeal Membrane Oxygenation Support 认领 引用
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作者 Da Li Yuqing Tian +1 位作者 Chengxin Weng Fuyou Liang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第6期2867-2882,共16页
Veno-arterial extracorporeal membrane oxygenation(VA-ECMO)is a life support intervention for patients with refractory cardiogenic shock or severe cardiopulmonary failure.However,the choice of cannulation strategy rema... Veno-arterial extracorporeal membrane oxygenation(VA-ECMO)is a life support intervention for patients with refractory cardiogenic shock or severe cardiopulmonary failure.However,the choice of cannulation strategy remains contentious,partly due to insufficient understanding of hemodynamic characteristics associated with the site of arterial cannulation.In this study,a geometrical multiscale model was built to offer a mathematical tool for addressing the issue.The outflow cannula of ECMO was inserted into the ascending aorta in the case of central cannulation,whereas it was inserted into the right subclavian artery(RSA)or the left iliac artery(LIA)in the case of peripheral cannulation.Numerical simulations conducted on three patient-specific aortas demonstrated that the central cannulation outperformed the two types of peripheral cannulation in evenly delivering ECMO flow to branch arteries.Both the central and RSA cannulations could maintain an approximately normal hemodynamic state in the aortas,although the area of aortic walls exposed to abnormal wall shear stress(WSS)was considerably enlarged in comparison with the normal physiological condition.In contrast,the LIA cannulation not only led to insufficient delivery of ECMO flow to the right upper body(with ECMO flow fractions5 Pa)and low time-averaged WSS(40 s)in the ascending aorta,which,along with abnormal WSS,may considerably increase the risk of thrombosis.In summary,our numerical study elucidated the impact of arterial cannulation site in VA-ECMO intervention on aortic hemodynamics and ECMO flow distribution.The findings provide compensatory biomechanical information for traditional clinical studies and may serve as a theoretical reference for guiding the evaluation and selection of cannulation strategies in clinical practice. 展开更多
关键词 Veno-arterial extracorporeal membrane oxygenation multiscale model cannulation strategy hemodynamics
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The influences of geometry on the hemodynamics and particle transport in model aorta 认领 引用
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作者 Wenyuan Chen Tao Zhang Yantao Yang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2025年第3期55-64,共10页
The present study investigates the infiuences of aorta geometry on hemodynamics and material transport.Based on the observation of the human aorta.two geometric paramelers are examined for a model aorta,savine the ane... The present study investigates the infiuences of aorta geometry on hemodynamics and material transport.Based on the observation of the human aorta.two geometric paramelers are examined for a model aorta,savine the anele spanned by the main aorticarc and the diameter of the descending aorta.irect numerical simulations are conducted for nine model aortas with difierencombinations of aorta arc and outlet diameter.Results reveal that the outlet diameter has a sienificant impact on aorta hemodynamics.A smaller outlet diameter compared to the inlet leads to accelerated blood fow in the descending segment,affecting fiowmorphology including the vortex structures,and increasing peak pressure gradient and wall shear stress.However,it reducesthe oscillatory shear index,indicating a more organized fow.Analyses show faster particle transport and reduced accumulativeresidence time for smaller outlet diameters,The arc anele has less sieniicant efiects on these properties.except for delaying thetime to reach the maximum pressure gradient during cjection.The research results may suggest that the diameter of the aorticoutlet has a greater impact on the fiow structures,while the arc angle has a relatively less efiect.These findings provide insightsinto the relation between hemodynamics and aorta geometry,with potential clinical implications. 展开更多
关键词 Aorta hemodynamics Immersed-boundary method Particle transport
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Hemodynamics in Portal Venous Based on 9.4 T Magnetic Resonance Velocimetry and Numerical Simulations 认领 引用
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作者 LI Jianing ZONG Zhipeng +2 位作者 ZHOU Tao ZHANG Jiang MA Haiteng 《Journal of Shanghai Jiaotong university(Science)》 EI 2025年第4期768-777,共10页
Portal vein stenosis is one of the common complications after liver transplantation in children.Accurate hemodynamic assessment is crucial for predicting the risk of complications after liver transplantation.In order ... Portal vein stenosis is one of the common complications after liver transplantation in children.Accurate hemodynamic assessment is crucial for predicting the risk of complications after liver transplantation.In order to predict the location of portal vein thrombosis after liver transplantation surgery,single-outlet and three-outlet vascular models were reconstructed from computed tomography images by commercial software MIMICS.The velocity field was measured using a 9.4 T magnetic resonance imaging scanner.Based on the experiment data of magnetic resonance velocimetry,computational fluid dynamics was verified,validated and then used to study the pressure and shear stresses on the wall of the two portal vein models.The simulation results can serve for the clinical prediction of early thrombosis after liver transplantation in portal vein. 展开更多
关键词 magnetic resonance imaging hemodynamics computational fluid dynamics portal venous thrombosis
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Regulation of Hemodynamic Stability in Urological Stone Patients During General Anesthesia Recovery Period Through Thermal Insulation Nursing Based on Temperature Intervention 认领 引用
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作者 Ying Chen 《Journal of Clinical and Nursing Research》 2025年第10期241-247,共7页
Objective:This study primarily analyzes the effectiveness of thermal insulation nursing(empowered by temperature intervention)in urological stone patients during the general anesthesia recovery period.Methods:A total ... Objective:This study primarily analyzes the effectiveness of thermal insulation nursing(empowered by temperature intervention)in urological stone patients during the general anesthesia recovery period.Methods:A total of 76 urological stone patients who underwent surgical treatment as the preferred option were selected as the research subjects.The earliest consultation time was May 2024,and the latest was May 2025.The patients were randomly divided into two groups using the random number table method,namely the observation group and the control group,with 38 patients in each group.The intervention indicators of the patients were compared.Results:The overall satisfaction rate in the observation group was higher than that in the control group,and the incidence of adverse reactions was lower,with p<0.05.At 0.5 hours,1 hour after surgery,and at the end of surgery,the body temperature in the observation group was significantly different from that in the control group,with p<0.05.Postoperatively,various hemodynamic indicators in the observation group were significantly different from those in the control group,with p<0.05.The time to clench the first upon verbal command,the time to open the eyes upon verbal command,the extubating time,and the recovery retention time in the observation group were all shorter than those in the control group,with p<0.05.Postoperative stress indicators and agitation scores at different time points in the observation group were significantly different from those in the control group,with p<0.05.Conclusion:For urological stone patients during the general anesthesia recovery period,actively implementing thermal insulation nursing combined with temperature intervention not only enhances hemodynamic stability but also effectively reduces the risk of adverse reactions such as hypothermia and shivering.It optimizes the recovery condition,significantly improves the stress state,and increases nursing satisfaction. 展开更多
关键词 Thermal insulation nursing Temperature intervention Urological stones General anesthesia recovery period Hemodynamics Stability
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Effects of Captopril and Nadolol on Renal Hemodynamics in Patients with Essential Hypertension 认领 引用
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作者 朱忠华 安锐 +3 位作者 张永学 龚培力 陈汇 曾繁典 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 1994年第1期45-48,共4页
The randomized single-blind study was designed to compare the effects of captopril Cap),and nadolol(And)on renal hemodynamics in 60 patients with essential hyperttnsion.They were divided into two groups at random.Cap ... The randomized single-blind study was designed to compare the effects of captopril Cap),and nadolol(And)on renal hemodynamics in 60 patients with essential hyperttnsion.They were divided into two groups at random.Cap was given in dosage of 37.5-75 mg/d per os and And 40-80 mg/d.The results show that both drugs increase the blood volume distributed to the kidneys from cardiac output(renal blood flow/cardiac output),Cap increasing 10% (P<0. 05) and And 8%(F<0.05) Renal vascular resistance(RVR)is lowered by the two drugs,13%(P<0. 05) by Cap and 11%(P<0.05) by And.These suggest that both drugs facilitate the maintenance of renal blood circulation in patients with essential hypeitension.being beneficial for long-term treatment of hypertension. 展开更多
关键词 captopril nadolol:essential hypertension renal hemodynamics systemic hemodynamics
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Amelioration of hemodynamics and oxygen metabolism by continuous venovenous hemofiltration in experimental porcine pancreatitis 认领 引用 被引量：27
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作者 HaoWang Zhen-HuanZhang +6 位作者 Xiao-WenYan wei-QinLi Da-XiJi Zhu-FuQuan De-HuaGong NingLi Jie-ShouLi 《World Journal of Gastroenterology》 SCIE CAS 2005年第1期127-131,共5页
AIM: To investigate the potential role of continuous venovenous hemofiltration (CVVH) in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP). METHODS: SAP model was produced by intraductal ... AIM: To investigate the potential role of continuous venovenous hemofiltration (CVVH) in hemodynamics and oxygen metabolism in pigs with severe acute pancreatitis (SAP). METHODS: SAP model was produced by intraductal injection of sodium taurocholate [4%, 1 mL/kg body weight (BW)] and trypsin (2 U/kg BW). Animals were allocated either to untreated controls as group 1 or to one of two treatment groups as group 2 receiving a low-volume CVVH [20 mL/(kg·h)], and group 3 receiving a high-volume CVVH [100 (mL/kg·h)]. Swan-Ganz catheter was inserted during the operation. Heart rate, arterial blood pressure, cardiac output, mean pulmonary arterial pressure, pulmonary arterial wedge pressure, central venous pressure, systemic vascular resistance, oxygen delivery, oxygen consumption, oxygen extraction ratio, as well as survival of pigs were evaluated in the study. RESULTS: Survival time was significantly prolonged by low-volume and high-volume CVVHs, which was more pronounced in the latter. High-volume CVVH was significantly superior compared with less intensive treatment modalities (low-volume CVVH) in systemic inflammatory reaction protection. The major hemodynamic finding was that pancreatitis-induced hypotension was significantly attenuated by intensive CVVH (87.4±12.5 kPa vs116.3±7.8 kPa,P＜0.01). The development of hyperdynamic circulatory failure was simultaneously attenuated, as reflected by a limited increase in cardiac output, an attenuated decrease in systemic vascular resistance and an elevation in oxygen extraction ratio. CONCLUSION: CVVH blunts the pancreatitis-induced cardiovascular response and increases tissue oxygen extraction. The high-volume CVVH is distinctly superior in preventing sepsis-related hemodynamic impairment. 展开更多
关键词 Pancreatitis Continuous venovenous hemofiltration Hemodynamics Oxygen metabolism
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Hemodynamic analysis of esophageal varices in patients with liver cirrhosis using color Doppler ultrasound 认领 引用 被引量：27
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作者 Feng-Hua Li Jing Hao +2 位作者 Jian-Guo Xia Hong-Li Li Hua Fang 《World Journal of Gastroenterology》 SCIE CAS 2005年第29期4560-4565,共6页
AIM： To study the portal hemodynamics and their relationship with the size of esophageal varices seen at endoscopy and to evaluate whether these Doppler ultrasound parameters might predict variceal bleeding in patien... AIM： To study the portal hemodynamics and their relationship with the size of esophageal varices seen at endoscopy and to evaluate whether these Doppler ultrasound parameters might predict variceal bleeding in patients with liver cirrhosis and portal hypertension. METHODS： One hundred and twenty cirrhotic patients with esophageal varices but without any previous bleeding were enrolled in the prospective study. During a 2-year observation period, 52 patients who had at least one episode of acute esophageal variceal hemorrhage constituted the bleeding group, and the remaining 68 patients without any previous hemorrhage constituted the non-bleeding group. All patients underwent endoscopy before or after color Doppler-ultrasonic examination, and images were interpreted independently by two endoscopists. The control group consisted of 30 healthy subjects, matched to the patient group in age and gender. Measurements of diameter, flow direction and flow velocity in the left gastric vein （LGV） and the portal vein （PV） were done in all patients and controls using color Doppler unit. After baseline measurements, 30 min after oral administration of 75 g glucose in 225 mL, changes of the diameter, flow velocity and direction in the PV and LGV were examined in 60 patients with esophageal varices and 15 healthy controls. RESULTS： The PV and LGV were detected successfully in 115 （96%） and 105 （88%） of 120 cirrhotic patients, respectively, and in 27 （90%） and 21 （70%） of 30 healthy controls, respectively. Among the 120 cirrhotic patients, 37 had F1, 59 had F2, and 24 had F3 grade varices. Compared with the healthy controls, cirrhotic group had a significantly lower velocity in the PV, a significantly greater diameter of the PV and LGV, and a higher velocity in the LGV. In the cirrhotic group, no difference in portal flow velocity and diameter were observed between patients with or without esophageal variceal bleeding （EVB）. However, the diameter and blood flow velocity of the LGV were significantly higher for EVB （＋） group compared with EVB （-） group （P〈0.01）. Diameter of the LGV increased with enlarged size of varices. There were differences between F1 and F2, F1 and F3 varices, but no differences between F2 and F3 varices （P = 0.125）. However, variceal bleeding was more frequent in patients with a diameter of LGV 〉6 mm. The flow velocity in the LGV of healthy controls was 8.70＋1.91 cm/s （n = 21）. In patients with liver cirrhosis, it was 10.3＋2.1 cm/s （n = 12） when the flow was hepatopetal and 13.5＋2.3 cm/s （n = 87） when it was hepatofugal. As the size of varices enlarged, hepatofugal flow velocity increased （P〈0.01） and was significantly different between patients with F1 and F2 varices and between patients with F2 and F3 varices. Variceal bleeding was more frequent in patients with a hepatofugal flow velocity 〉15 cm/s （32 of 52 patients, 61.5%）. Within the bleeding group, the mean LGV blood flow velocity was 16.6＋2.62 cm/s. No correlation was observed between the portal blood flow velocity and EVB. In all healthy controls, the flow direction in the LGV was hepatopetal, toward the PV. In patients with F1 varices, flow direction was hepatopetal in 10 patients, to-and-fro state in 3 patients, and hepatofugal in the remaining 18. The flow was hepatofugal in 91% patients with F2 and all F3 varices. Changes in diameter of the PV and LGV were not significant before and after ingestion of glucose （PV： 1.41＋1.5 cm before and 1.46＋1.6 cm after; LGV： 0.57＋1.7 cm before and 0.60＋1.5 cm after）. Flow direction in the LGV was hepatopetal and to-and-fro in 16 patients and hepatofugal in 44 patients before ingestion of glucose. Flow direction changed to hepatofugal in 9 of 16 patients with hepatopetal and to-and-fro blood flow after ingestion of glucose. In 44 patients with hepatofugal blood flow in the LGV, a significant increase in hepatofugal flow velocity was observed in 38 of 44 patients （86%） with esophageal varices. There was a relationship between the percentage changes in flow velocity and the size of varices. Patients who responded excessively to food ingestion might have a high risk for bleeding. The changes of blood flow velocity in the LGV were greater than those in the PV （LGV： 28.3＋26.1%, PV： 7.2＋13.2%, P〈0.01）, whereas no significant changes in the LGV occurred before and after ingestion of glucose in the control subjects. CONCLUSION： Hemodynamics of the PV is unrelated to the degree of endoscopic abnormalities in patients with liver cirrhosis. The most important combinations are endoscopic findings followed by the LGV hemodynamics. Duplex-Doppler ultrasonography has no value in the identification of patients with cirrhosis at risk of variceal bleeding. Hemodynamics of the LGV appears to be superior to those of the PV in predicting bleeding. 展开更多
关键词 Hemodynamics Esophageal varices Liver cirrhosis Color Doppler ultrasound
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Spinal Cord Stimulation Frequency Influences the Hemodynamic Response in Patients with Disorders of Consciousness 认领 引用 被引量：17
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作者 Juanning Si Yuanyuan Dang +7 位作者 Yujin Zhang Yaxin Li Wenyue Zhang Yi Yang Yue Cui Xiaoping Lou Jianghong He Tianzi Jiang 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第4期659-667,共9页
Spinal cord stimulation(SCS)is a promising technique for treating disorders of consciousness(DOCs).However,differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear.In t... Spinal cord stimulation(SCS)is a promising technique for treating disorders of consciousness(DOCs).However,differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear.In this pilot study,functional near-infrared spectroscopy was used to measure the hemodynamic responses of 10 DOC patients to different SCS frequencies(5 Hz,10 Hz,50 Hz,70 Hz,and 100 Hz).In the prefrontal cortex,a key area in consciousness circuits,we found significantly increased hemodynamic responses at 70 Hz and 100 Hz,and significantly different hemodynamic responses between 50 Hz and 70 Hz/100 Hz.In addition,the functional connectivity between prefrontal and occipital areas was significantly improved with SCS at 70 Hz.These results demonstrated that SCS modulates the hemodynamic responses and long-range connectivity in a frequency-specific manner(with 70 Hz apparently better),perhaps by improving the cerebral blood volume and information transmission through the reticular formation-thalamus-cortex pathway. 展开更多
关键词 Disorder of consciousness-Spinal cord stim-ulation Frequency Functional near-infrared spectroscopy Hemodynamic response
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Early changes of hepatic hemodynamics measured by functional CT perfusion in a rabbit model of liver tumor 认领 引用 被引量：10
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作者 Guo-Lin Ma Rong-Jie Bai +5 位作者 Hui-Jie Jiang Xue-Jia Hao Xu-Peng Dong Da-Qing Li Xin-Ding Liu Lai Wei 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2012年第4期407-411,共5页
BACKGROUND:Early detection and treatment of hepatocellular carcinoma is crucial to improving the patients’survival.The hemodynamic changes caused by tumors can be serially measured using CT perfusion.In this study,we... BACKGROUND:Early detection and treatment of hepatocellular carcinoma is crucial to improving the patients’survival.The hemodynamic changes caused by tumors can be serially measured using CT perfusion.In this study,we used a CT perfusion technique to demonstrate the changes of hepatic hemodynamics in early tumor growth,as a proof-of-concept study for human early hepatocellular carcinoma.METHODS:VX2 tumors were implanted in the liver of ten New Zealand rabbits.CT perfusion scans were made 1 week(early)and 2 weeks(late)after tumor implantation.Ten normal rabbits served as controls.CT perfusion parameters were obtained at the tumor rim,normal tissue surrounding the tumor,and control liver;the parameters were hepatic blood flow,hepatic blood volume,mean transit time,permeability of capillary vessel surface,hepatic arterial index,hepatic arterial perfusion and hepatic portal perfusion.Microvessel density and vascular endothelial growth factor were correlated.RESULTS:At the tumor rim,compared to the controls,hepatic blood flow,hepatic blood volume,permeability of capillary vessel surface,hepatic arterial index,and hepatic arterial perfusion increased,while mean transit time and hepatic portal perfusion decreased on both early and late scans(P<0.05).Hepatic arterial index increased(135%,P<0.05),combined with a sharp increase in hepatic arterial perfusion(182%,P<0.05)and a marked decrease in hepatic portal perfusion(-76%,P<0.05)at 2 weeks rather than at 1 week(P<0.05).Microvessel density and vascular endothelial growth factor showed significant linear correlations with hepatic blood flow,permeability of capillary vessel surface and hepatic arterial index,but not with hepatic blood volume or mean transit time.CONCLUSION:The CT perfusion technique demonstrated early changes of hepatic hemodynamics in this tumor model as proof-of-concept for early hepatocellular carcinoma detection in humans. 展开更多
关键词 liver tumor computed tomography hemodynamic animal model perfusion imaging
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