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The prognostic significance of prostate-specific antigen dynamics during abiraterone therapy in patients with high-risk metastatic hormone-sensitive prostate cancer 认领 引用
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作者 Qian Wang Ming Zhang +8 位作者 Qi-Yu Zhu Hong Zeng Jin-Dong Dai Ke Huang Si-Cheng Wan Yi-Fu Shi Xing-Ming Zhang Hao Zeng Peng-Fei Shen 《Asian Journal of Andrology》 SCIE CAS CSCD 2026年第3期304-309,共6页
To evaluate the prognostic significance of prostate-specific antigen(PSA)decline depth and duration in patients with high-risk metastatic hormone-sensitive prostate cancer(mHSPC)undergoing abiraterone treatment.We ret... To evaluate the prognostic significance of prostate-specific antigen(PSA)decline depth and duration in patients with high-risk metastatic hormone-sensitive prostate cancer(mHSPC)undergoing abiraterone treatment.We retrospectively analyzed data from 153 high-risk patients with mHSPC receiving first-line abiraterone therapy.Patients were stratified based on PSA dynamics during treatment.Kaplan–Meier survival analysis and Cox proportional hazards regression were used to assess the associations between PSA decline patterns,PSA progression-free survival(PSA-PFS),radiographic PFS(rPFS),and overall survival(OS).Among the 153 patients,85 exhibited PSA nadir4 ng ml−1.During abiraterone treatment,PSA nadir<0.2 ng ml−1 was significantly associated with improved median PSA-PFS(51.0 months vs 18.5 months vs 6.9 months,P<0.0001),median rPFS(52.0 months vs 24.3 months vs 10.3 months,P<0.0001),and median OS(not reached vs 48.5 months vs 28.1 months,P<0.0001)compared with PSA nadir≥0.2 ng ml-1 and<4 ng ml-1,and PSA nadir≥4 ng ml-1.In the cohort with PSA nadir<0.2 ng ml−1,achieving PSA<0.2 ng ml−1 within 6 months and maintaining this level for over 10 months significantly enhanced clinical outcomes,as evidenced by median PSA-PFS(not reached vs 26.9 months,P<0.0001),median rPFS(not reached vs 27.5 months,P<0.0001),and median OS(not reached vs 44.4 months,P<0.0001).Cox regression analysis revealed that achieving PSA<0.2 ng ml−1 within 6 months post-treatment and sustaining this level for over 10 months are independent prognostic factors.In high-risk patients with mHSPC receiving first-line abiraterone,sustained PSA suppression is a key indicator of therapeutic response.The rate,depth,and duration of PSA decline are critical prognostic factors. 展开更多
关键词 dynamics high-risk prognostic prostate cancer PSA
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Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection 认领 引用
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作者 Lingyun Ji Xiao Wang +7 位作者 Ruixian Jiao Ji Yang Jiaqi Han Bowen Xu Yang Zhou Jing Wu Xiaowen Pu Wenhong Zhang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期215-222,共8页
Objective The aim of this study was to analyze the correlation between the levels of 12 cytokines in the cervical microenvironment and cervical intraepithelial neoplasia in patients with high-risk human papillomavirus... Objective The aim of this study was to analyze the correlation between the levels of 12 cytokines in the cervical microenvironment and cervical intraepithelial neoplasia in patients with high-risk human papillomavirus(HR-HPV)infection.Methods Female patients(n=73)with HR-HPV infection were enrolled and divided into a high-grade squamous intraepithelial lesion(HSIL)group(n=33)and a non-HSIL(N-HSIL)group(n=40),which include low-grade squamous intraepithelial lesions and inflammation.Healthy screening subjects(n=31)with negative HR-HPV results were enrolled as a control group.We examined contemporaneous plasma and secretory cytokines from 25 study subjects to investigate the difference between systemic cytokine profiles and the local microenvironment immunity using the Wilcoxon matched-pairs signed rank test.The 12 cytokines from cervical secretions were compared between the three groups using the Mann-Whitney test,and logistic regression was used to analyze HSIL and N-HSIL.Results There were statistical differences in eight cytokines(IL-2,IL-6,TNF-α,IFN-γ,IL-1β,IL-12p70,IFN-α,and IL-8)between cervical secretion and plasma of the same patient,and seven cytokines were statistically different between the control and other two groups.We selected four independent variables(TNF-α,IFN-γ,IL-12p70,and IFN-α)commonly identified by univariate regression analysis and non-parametric tests for multivariate logistic regression analysis.Based on this model,HSIL could be predicted in patients with HR-HPV infection,with the area under the curve being 0.76.Conclusion The systemic cytokine profile cannot reflect the local microenvironment immunity,and the occurrence of HSIL is related to the cytokine levels in the cervical microenvironment. 展开更多
关键词 High-risk human papillomavirus Cytokines High-grade squamous intraepithelial lesion
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Prenatal exposure to bisphenols,metals,and risk of fetal chromosome numerical abnormalities in high-risk pregnancies:Independent,combined,and interactive effects 认领 引用
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作者 Jinglin Li Mengli Yang +8 位作者 Jingting Chen Dan Wang Hongyue Sun Zinuo Wang Xiaoyu Li Ying Chang Baoqin Huang Xi Chen Nai-jun Tang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第2期51-59,共9页
Prenatal exposure to bisphenols and metals has raised significant concerns regarding their potential impact on fetal development,particularly the risk of fetal chromosome numerical abnormalities(CNA).In this case-cont... Prenatal exposure to bisphenols and metals has raised significant concerns regarding their potential impact on fetal development,particularly the risk of fetal chromosome numerical abnormalities(CNA).In this case-control study,we analyzed bisphenol and metal concentrations in amniotic fluid of high-risk pregnant women undergoing amniocentesis.Concentrations of bisphenols and metals were measured using ultra-performance liquid chromatography-tandem mass spectrometry and inductively coupled plasma-mass spectrometry,respectively.Logistic regression and quantile-based g-computation were applied to evaluate individual and combined effects,while dose-response relationships were assessed using restricted cubic splines.Our findings indicated that bisphenol S(BPS),bisphenol Z(BPZ),bisphenol AF(BPAF),antimony(Sb),and vanadium(V)were significantly associated with an increased risk of CNA when analyzed individually,whereas manganese,iron,copper(Cu),nickel(Ni),and zinc(Zn)were significantly and inversely associated with CNA risk.Combined exposure to bisphenol and metal mixtures was associated with an increased risk of CNA in multi-pollutant models.Cu and Ni exhibited a positive additive interaction.Furthermore,BPS,BPZ,and BPAF were individually associated with an increased risk of Down syndrome,while Zn was associated with a decreased risk of Down syndrome.BPS,Sb,V,and Zn were individually associated with an increased risk of Klinefelter syndrome.These findings underscore the potential role of prenatal bisphenol and metal exposure in the pathogenesis of fetal CNA,highlighting both additive and synergistic effects. 展开更多
关键词 Bisphenol Metal Chromosome numerical abnormalities High-risk pregnant women Down syndrome Klinefelter syndrome
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Barriers and facilitators in the identification and management of high-risk pregnancy:A scoping review of literature from India 认领 引用
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作者 Sakshi Verma Mukti Khetan +2 位作者 Rakhi Dhankhar Ramesh Kumar Huda Ramesh Kumar Sangwan 《Asian pacific Journal of Reproduction》 CAS 2026年第3期110-123,共14页
Objective:To identify the barriers and facilitators in the identification and management of high-risk pregnancies in India.Methods:A systematic search of PubMed and Google Scholar was conducted from the inception of d... Objective:To identify the barriers and facilitators in the identification and management of high-risk pregnancies in India.Methods:A systematic search of PubMed and Google Scholar was conducted from the inception of database till 27 March 2024,using predefined keywords and search terms,including“high risk pregnancy,”“identification,”“management,”“barrier,”“challenge,”“facilitator,”“enabler,”and“India,”combined using Boolean operators(AND/OR).Only studies published in English were included.Screening was conducted using Rayyan software.Data were extracted into structured tables and synthesized using a qualitative thematic approach to identify key barriers and facilitators in the identification and management of high-risk pregnancies.Results:A total of 144 publications were identified.After screening based on eligibility criteria,21 studies were finally included in the review.The included studies highlighted multiple barriers in the identification and management of high-risk pregnancies,including knowledge and awareness gaps among women and healthcare providers,inconsistent clinical management,and inadequate infrastructure.Financial constraints and cultural factors further added to the challenges.Women in tribal and rural areas faced additional barriers such as geographical isolation,lack of transportation,and limited access to specialized maternal healthcare.Facilitators identified in the literature included social support networks,the role of community health workers in bridging gaps between facilities and communities,and targeted education programs.Improved health literacy,standardized clinical protocols,and tailored management strategies were also reported as important facilitators.Conclusions:This review highlights the importance of strengthening healthcare infrastructure and addressing the identified barriers comprehensively to improve maternal and fetal outcomes.Enhancing awareness,empowering community health workers,and adopting standardized management protocols can contribute significantly to better identification and management of high-risk pregnancies in India. 展开更多
关键词 Barriers Facilitators High-risk pregnancy Healthcare India
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Development of the Framework for Traffic Accident Visualization Analysis (F-TAVA) Based on the Conceptualization of High-Risk Situations in Autonomous Vehicles 认领 引用
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作者 Heesoo Kim Minwook Kim +2 位作者 Hyorim Han Soongbong Lee Tai-jin Song 《Computers, Materials & Continua》 SCIE EI 2026年第5期856-880,共25页
Autonomous vehicles operate without direct human intervention,which introduces safety risks that differ from those of conventional vehicles.Although many studies have examined safety issues related to autonomous drivi... Autonomous vehicles operate without direct human intervention,which introduces safety risks that differ from those of conventional vehicles.Although many studies have examined safety issues related to autonomous driving,high-risk situations have often been defined using single indicators,making it difficult to capture the complex and evolving nature of accident risk.To address this limitation,this study proposes a structured framework for defining and analyzing high-risk situations throughout the traffic accident process.High-risk situations are described using three complementary indicators:accident likelihood,accident severity,and accident duration.These indicators explain how risk emerges,increases,and persists over time.Based on this concept,a framework for traffic accident visualization analysis is developed to support phase-specific risk assessment and visualization.The framework combines accident-phase information with factor-level risk contributions,allowing systematic identification of key factors and their interactions across different accident stages.Using combinations of the three indicators,high-risk situations are classified into twenty-seven distinct types,providing a clear typology for complex accident scenarios involving autonomous vehicles.The applicability of the proposed framework is demonstrated through two representative accident scenarioswith different risk characteristics.The results showthat the framework effectively captures interactions among multiple risk factors,explains how risk levels change from pre-crash to post-crash phases,and identifies contributing factors that are difficult to detect using conventional traffic accident investigation methods.Overall,the proposed framework offers a practical basis for autonomous vehicle accident analysis,safety evaluation,and policy-related decision-making. 展开更多
关键词 Autonomous vehicle high-risk situations traffic accident traffic safety
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Artificial intelligence-assisted endoscopists improve the detection rate of high-risk gastric lesions:A propensity score-matched retrospective study 认领 引用
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作者 Jia-Xiu Ying Si-Yan Yan +8 位作者 Xin-Yu Fu Yi-Jing Zhou Jing-Jing Zhou Yan Yang Xian-Bin Zhou Zhen-Zhen Wang Shao-Wei Li Li-Na Fang Xin-Li Mao 《World Journal of Gastroenterology》 SCIE CAS 2026年第21期48-62,共15页
BACKGROUND Early detection of high-risk gastric lesions(HrGLs)during esophagogastroduodenoscopy(EGD)is challenging,and artificial intelligence(AI)may enhance its diagnostic accuracy.AIM To evaluate the efficacy of AI ... BACKGROUND Early detection of high-risk gastric lesions(HrGLs)during esophagogastroduodenoscopy(EGD)is challenging,and artificial intelligence(AI)may enhance its diagnostic accuracy.AIM To evaluate the efficacy of AI in improving HrGLs detection during EGD.METHODS We included patients who underwent EGD examinations at the Taizhou Hospital between August 1,2023,and July 31,2024.The primary outcome was the detection rate of HrGLs between the AI-assisted and non-AI-assisted groups.The secondary objective was to explore the impact of AI on various aspects of the gastroscopy process in clinical practice.RESULTS Through propensity score matching,15528 patients(7764 in the AI-assisted group and 7764 in the non-AI-assisted group)were included in the final analysis.A total of 110 HrGLs(AI:73 vs non-AI:37)were detected.The detection rate of HrGLs in the AI-assisted group was significantly higher than that in the non-AI-assisted group(0.94%vs 0.48%,odds ratio=1.98,95%confidence interval:1.33-2.95,P=0.001).This enhancement was consistently observed across all HrGL subtypes,including high-grade intraepithelial neoplasia,low-grade intraepithelial neoplasia,and early gastric cancer.Notably,AI assistance was of the greatest benefit when combined with experienced endoscopists and during procedures performed under anesthesia.CONCLUSION AI significantly improved HrGLs detection,highlighting its value as a clinical adjunct. 展开更多
关键词 Artificial intelligence High-risk gastric lesions Early gastric cancer Precancerous lesions Detection rate
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Research on the Foot Care Journey Map for Patients with Diabetic High-Risk Feet 认领 引用
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作者 Meijie Zheng Xiaohui Ning +7 位作者 Wei Li Wenxiu Liu Jianli Yang Bohan Qu Ziyu Gui Qiong Meng Huifeng Jiao Xian Li 《Journal of Clinical and Nursing Research》 2026年第7期13-24,共12页
Objective:To explore the full-cycle foot care experiences and real needs of patients with high-risk diabetic feet based on patient journey maps,providing a reference for optimizing the entire preventive care model and... Objective:To explore the full-cycle foot care experiences and real needs of patients with high-risk diabetic feet based on patient journey maps,providing a reference for optimizing the entire preventive care model and delaying the onset and progression of diabetic foot.Methods:A phenomenological research method from qualitative research was employed.From September to December 2025,15 patients with high-risk diabetic feet were selected as the study subjects.Longitudinal semi-structured interviews were conducted on the first day of admission,the day before discharge,three months after discharge,and six months after discharge.Content analysis was used to extract themes and construct and draw a foot care journey map for patients with high-risk diabetic feet.Results:The patients’full-cycle care experiences were summarized into three stages:examination and diagnosis,hospitalization,and home care after discharge.A total of 21 themes were extracted,revealing significant stage-specific differences in care tasks,emotional states,distressing issues,and care needs across different treatment stages.Conclusion:Foot care for patients with high-risk diabetic feet spans the entire treatment process.Clinical healthcare professionals should establish a phased,continuous,and individualized foot preventive care system to effectively prevent and control the onset and progression of diabetic foot. 展开更多
关键词 High-risk diabetic foot Foot care Journey map Self-management Continuous care Qualitative research
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Clinical Analysis of High-Risk Factors in 50 Cases of Non-Alcoholic Fatty Liver Disease 认领 引用
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作者 LIU Xiaohui 《外文科技期刊数据库（文摘版）医药卫生》 2026年第4期102-106,共5页
Objective: To investigate the high-risk factors influencing non-alcoholic fatty liver disease (NAFLD). Methods: A total of 50 NAFLD patients admitted to the Department of Gastroenterology from January to December 2025... Objective: To investigate the high-risk factors influencing non-alcoholic fatty liver disease (NAFLD). Methods: A total of 50 NAFLD patients admitted to the Department of Gastroenterology from January to December 2025 were enrolled as the observation group, while 50 healthy individuals undergoing routine physical examinations during the same period served as the control group. Serum lipid metabolism parameters, uric acid levels, and liver function indicators were compared between the two groups. Results: The observation group exhibited significantly higher values for body mass index (BMI), hypertension prevalence, diabetes prevalence, triglycerides, total cholesterol, LDL-C, lipoprotein A, uric acid levels, and abnormal liver function rates compared to the control group, whereas HDL-C levels were significantly lower (P <0.05). High BMI (≥24 kg/m²), hypertension, diabetes, hypertriglyceridemia (≥1.7 mmol/L), low HDL-C (≤1.04 mmol/L), and hyperuricemia (≥420 μmol/L in males and ≥360 μmol/L in females) were identified as independent high-risk factors for NAFLD (P <0.05), with OR values of 6.668,4.798,4.298,5.987,5.234, and 4.687, respectively;all 95% confidence intervals excluded 1. Conclusion: The development of NAFLD results from multifactorial interactions. Clinical practice should establish a stratified screening system targeting these high-risk factors and implement individualized intervention strategies, including weight management, metabolic regulation, and control of underlying diseases, to reduce the risk of NAFLD onset and delay disease progression. 展开更多
关键词 Non-alcoholic fatty liver disease High-risk factors Body mass index Lipid metabolism Uric acid
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The Impact of Mother-Infant Separation on the Physical and Mental Health of Women with High-Risk Pregnancies and Corresponding Nursing Strategies 认领 引用
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作者 Qing Yang 《Journal of Clinical and Nursing Research》 2026年第1期145-152,共8页
Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 ... Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 high-risk pregnancy patients treated in our hospital from January 2023 to January 2024 were selected as the study subjects.These patients were randomly divided into an observation group and a control group(40 cases each)using a random number table.The control group received routine high-risk pregnancy nursing care,while the observation group received specialized maternal-infant separation nursing interventions in addition to routine care.The psychological and physiological states and nursing satisfaction of the two groups were compared before and after the intervention.Results:The SAS scores,SDS scores,and sleep quality scores of the observation group were significantly lower than those of the control group,with statistically significant differences(p<0.05).The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the initiation time of lactation was significantly earlier than that in the control group,with both differences being statistically significant(p<0.05).The nursing satisfaction of the observation group was significantly higher than that of the control group(80%vs.32/40),with a statistically significant difference(p<0.05).Conclusion:Maternal-infant separation exacerbates anxiety and depression in high-risk pregnancy patients,reduces sleep quality,increases the risk of postpartum hemorrhage,and delays the initiation of lactation.Specialized nursing interventions for maternal-infant separation can improve the physical and mental state of high-risk pregnancy patients,reduce the incidence of postpartum complications,and enhance nursing satisfaction,making them worthy of clinical application and promotion. 展开更多
关键词 Mother-infant separation High-risk pregnancy women Physical and mental health Nursing strategies
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Effect of systolic blood pressure status on coronary inflammation and high-risk plaque characteristics 认领 引用 被引量：2
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作者 Cui-Ping Jiang Yuan-Kang Liu +6 位作者 Pan-Pan Cheng Yue Dong Xiang Wang Fan-Yu Wu Yu-Xuan Xia Peng-Yun Wang Xiang-Yang Xu 《World Journal of Diabetes》 SCIE 2025年第4期128-143,共16页
BACKGROUND Inadequately controlled hypertension often leads to an increased cardiovascular death rate in type 2 diabetes mellitus(T2DM).It remains unclear whether systolic blood pressure(SBP)status of hypertension is ... BACKGROUND Inadequately controlled hypertension often leads to an increased cardiovascular death rate in type 2 diabetes mellitus(T2DM).It remains unclear whether systolic blood pressure(SBP)status of hypertension is related to coronary inflammation and plaques in T2DM.AIM To evaluate whether SBP variability(SBPV)and levels of hypertension are related to coronary inflammation and plaques in T2DM patients using coronary computed tomography angiography(CCTA).METHODS This retrospective study involved 881 T2DM patients with CCTA images,including 668 hypertension and 213 normotension patients.Hypertension patients were subgroup based on SBP status:(1)SBPV:Low(<8.96 mmHg)and high(≥8.96 mmHg)groups;and(2)SBP levels:Controlled(<140 mmHg)and uncontrolled(≥140 mmHg)groups.Pericoronary adipose tissue(PCAT)attenuation,high-risk plaques(HRPs)and obstructive stenosis(OS)were evaluated by CCTA.Propensity score matching was utilized to compare these CCTA findings for these groups.The impact of SBPV and SBP levels of hypertension on these CCTA findings in T2DM patients were evaluated by multivariate logistic regression and multivariable linear regression.RESULTS PCAT attenuation of the left anterior descending artery(LAD),any low attenuation plaque(LAP),any spotty calcification(SC),any positive remodeling(PR),and OS had significant differences between the hypertension group and the normotension group,as well as between the high SBPV or uncontrolled SBP group and the low SBPV or controlled SBP group(all P<0.05).Hypertension was independently positively correlated with LADPCAT attenuation(β=1.815,P=0.010),LAP(OR=1.612,P=0.019),SC(OR=1.665,P=0.013),PR(OR=1.549,P=0.033),and OS(OR=1.928,P=0.036)in all T2DM patients.Additionally,high SBPV and uncontrolled SBP were independently positively correlated with LAD-PCAT attenuation(high SBPV:β=1.673,P=0.048;uncontrolled SBP:β=2.370,P=0.004)and PR(high SBPV:OR=1.903,P=0.048;uncontrolled SBP:OR=2.230,P=0.013)in T2DM patients with hypertension.CONCLUSION Inadequately controlled hypertension,including high SBPV and/or uncontrolled SBP levels,may be related to increased coronary artery inflammation,HRPs,and OS in T2DM,leading to increased cardiovascular risk.Achieving both low SBPV and controlled SBP levels simultaneously,especially in individuals with T2DM and hypertension,warrants clinical attention. 展开更多
关键词 Type 2 diabetes mellitus Hypertension Coronary computed tomography angiography Pericoronary adipose tissue attenuation High-risk plaques
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Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma 认领 引用 被引量：1
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作者 Yi Wang Yuting Yan +15 位作者 Dandan Shan Jiawen Chen Wei Liu Tingyu Wang Gang An WeiweiSui Wenyang Huang Wenjie Xiong Huimin Liu Qi Sun Huijun Wang Zhijian Xiao JianxiangWang Lugui Qiu Dehui Zou Shuhua Yi 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第2期177-189,共13页
Objective:Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma(MCL)than those in Western.Given the success and tolerability of R-DA... Objective:Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma(MCL)than those in Western.Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas,we designed a prospective,phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL.The primary endpoint was the complete remission rate(CRR)at the end of induction(EOI).Methods:A total of 55 patients were enrolled.The CRR at the EOI was 89.1%[95%confidence interval(CI)78%±96%],and the overall response rate was 98.1%(95%CI 90%±100%).Most patients with bone marrow involvement quickly attained minimal residual disease(MRD)negative status,with a 95.7%rate at the EOI.Results:The 3-year progression-free survival(PFS)and overall survival rates were 66.3%and 83.2%,respectively.No patients discontinued treatment because of adverse events.Univariate analysis identified pathologic morphology and TP53 mutations as risk factors for PFS.However,high tumor proliferative activity and certain cytogenetic abnormalities showed no significant adverse prognostic significance.Conclusions:Intensive therapy based on a high cytarabine dose and continuously administered EDOCH achieved a high MRDnegative rate and provides an optional induction choice for young patients with MCL with high-risk factors. 展开更多
关键词 Mantle cell lymphoma immunochemotherapy high-risk factors minimal residual disease adverse events
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High-risk extranodal natural killer/T-cell lymphoma patients could benefit more from allogeneic hematopoietic stem cell transplantation as consolidation:A real-world multicenter analysis in China 认领 引用
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作者 Yuewen Wang Yi Xia +18 位作者 Zhenyang Gu Yu Chang Lei Yang Peipei Yang Yanmin Zhao Chunli Zhang Na Wang Shenmiao Yang Yang Yang Chuanhe Jiang Leqing Cao Daoxing Deng Haiyang Lu Fengrong Wang Mingzhi Zhang Yang Cao Xiaoxia Hu Ting Niu Xiaodong Mo 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2025年第5期686-704,共19页
Objective:Both allogeneic hematopoietic stem cell transplantation(allo-HSCT)and autologous HSCT(ASCT)are important therapies for extranodal natural killer/T-cell lymphoma(ENKTCL);however,no large-scale,multicenter stu... Objective:Both allogeneic hematopoietic stem cell transplantation(allo-HSCT)and autologous HSCT(ASCT)are important therapies for extranodal natural killer/T-cell lymphoma(ENKTCL);however,no large-scale,multicenter study has compared the efficacy and safety between allo-HSCT and ASCT in these patients.Our multicenter,real-world study aimed to evaluate the outcomes of allo-HSCT vs.ASCT as consolidation in ENKTCL patients who had achieved a complete response(CR)or partial response(PR).Methods:This was a multicenter,retrospective study with nine hospitals in China,and 114 patients with ENKTCL were enrolled.Sixty patients received ASCT and 54 received allo-HSCT.The primary outcome was progression-free survival(PFS).In the sensitivity analysis,propensity score matching(PSM)analyses were conducted to adjust for baseline prognostic factors.Landmark analysis were conducted to minimize immortal-time bias.Results:Patients in the allo-HSCT group presented with more adverse prognostic factors.Allo-HSCT group showed a significantly better PFS and a lower disease progression rate compared with ASCT group in patients with Ann Arbor stageⅢ/Ⅳdisease(PFS:100%vs.82.0%,P=0.023;disease progression rate:0 vs.25.4%,P=0.024),those with intermediate/high prognostic index of natural killer lymphoma(PINK)scores(PFS:100%vs.84.4%,P=0.034;disease progression rate:0 vs.22.1%,P=0.034),those with intermediate/high international prognostic index(IPI)scores(PFS:100%vs.82.0%,P=0.038;disease progression rate:0 vs.25.4%,P=0.038),or those receiving HSCT at PR(PFS:100%vs.50%,P=0.046;disease progression rate:0 vs.50%,P=0.046)at the 1.5-4.0 follow-up.In multivariate analysis,receiving ASCT was significantly associated with a poorer PFS[hazard ratio(HR)=2.23,P=0.038]and overall survival(OS)(HR=2.45,P=0.045).In the sensitivity analysis,patients receiving allo-HSCT showed a significantly better PFS(70.3%vs.39.1%,P=0.039),OS(73.9%vs.42.0%,P=0.044),and a lower disease progression rate(22.6%vs.57.0%,P=0.017)compared with those receiving ASCT after propensity score matching.Conclusions:ENKTCL patients with high-risk characteristics could benefit more from allo-HSCT as consolidation. 展开更多
关键词 Extranodal natural killer/T-cell lymphoma allogeneic hematopoietic stem cell transplantation autologous hematopoietic stem cell transplantation consolidation therapy high-risk disease
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Sequential living donor liver transplantation after liver resection optimizes outcomes for patients with high-risk hepatocellular carcinoma 认领 引用 被引量：2
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作者 Itsuko Chih-Yi Chen Leona Bettina P Dungca +1 位作者 Chee-Chien Yong Chao-Long Chen 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2025年第1期50-56,共7页
Background:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. While liver transplantation (LT) provides the best long-term survival, it is constrained by organ scarcity and strict criteria.... Background:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. While liver transplantation (LT) provides the best long-term survival, it is constrained by organ scarcity and strict criteria. Liver resection (LR) is often the initial treatment for patients with solitary tumors and preserved liver function. The high recurrence rates associated with LR has prompted the exploration of sequential living donor liver transplantation (seq LDLT) after LR as a strategy for HCC patients with high-risk of recurrence.Methods:We analyzed data from 27 adult patients who underwent seq LDLT after LR for HCC at Kaohsiung Chang Gung Memorial Hospital (KCGMH) between June 1994 and December 2023. Patients were selected based on high-risk histopathological features post-LR or as part of downstaging strategy. Outcomes measured included overall survival (OS) and disease-free survival (DFS).Results:Among 765 HCC patients who underwent LDLT, 204 received LR before LDLT, and 27 underwent seqL DLT. Five patients (19%) underwent living donor liver transplantation (LDLT) following LR as a downstaging strategy while the rest received seqL DLT as a preemptive strategy. The median age was 53.5 years with 85%males. Chronic hepatitis B was the predominant underlying disease (74%). The 1-, 3-, and 5-year OS and DFS rates were 100%, 96.0%, 96.0%and 100%, 96.2%, 96.2%, respectively, with two patients experiencing HCC recurrence. One patient died from HCC recurrence. High-risk histopathological features included microvascular invasion (52%), satellite nodules (15%), multiple tumors (26%), tumors> 5 cm(19%), and a total tumor diameter> 10 cm (7%).Conclusions:Seq LDLT offers a promising, tailored approach for managing HCC with adverse histopathologic features. Combining seq LDLT, downstaging strategies, and multidisciplinary treatments can achieve satisfactory OS and DFS in carefully selected patients, highlighting the need for refined criteria to identify the best candidates. 展开更多
关键词 Living donor liver transplantation Liver resection High-risk hepatocellular carcinoma Sequential living donor liver transplantation Salvage living donor liver transplantation
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Effect of hospital-community-home collaborative health management on symptoms,cognition,anxiety,and depression in high-risk individuals for stroke 认领 引用 被引量：2
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作者 Jing Wang Chen-Xi Zhao +5 位作者 Jin Tian Yan-Ru Li Kai-Fang Ma Rui Du Meng-Kun Li Rui Hu 《World Journal of Psychiatry》 SCIE 2025年第3期78-87,共10页
BACKGROUND Effective health management for high-risk stroke populations is essential.The hospital-community-home(HCH)collaborative health management(CHM)model leverages resources from hospitals,communities,and familie... BACKGROUND Effective health management for high-risk stroke populations is essential.The hospital-community-home(HCH)collaborative health management(CHM)model leverages resources from hospitals,communities,and families.By integrating patient information across these three domains,it facilitates the delivery of tailored guidance,health risk assessments,and three-in-one health education.AIM To explore the effects of the HCH-CHM model on stroke risk reduction in highrisk populations.METHODS In total,110 high-risk stroke patients screened in the community from January 2019 to January 2023 were enrolled,with 52 patients in the control group receiving routine health education and 58 in the observation group receiving HCH-CHM model interventions based on routine health education.Stroke awareness scores,health behavior levels,medication adherence,blood pressure,serum biochemical markers(systolic/diastolic blood pressure,total cholesterol,and triglyceride),and psychological measures(self-rating anxiety/depression scale)were evaluated and compared between groups.RESULTS The observation group showed statistically significant improvements in stroke awareness scores and health behavior levels compared to the control group(P<0.05),with notable enhancements in lifestyle and dietary habits(P<0.05)and reductions in postintervention systolic blood pressure,diastolic blood pressure,total cholesterol,triglyceride,self-rating anxiety scale,and self-rating depression scale scores(P<0.05).CONCLUSION The HCH-CHM model had a significant positive effect on high-risk stroke populations,effectively increasing disease awareness,improving health behavior and medication adherence,and appropriately ameliorating blood pressure,serum biochemical marker levels,and negative psychological symptoms. 展开更多
关键词 Hospital-community-home-collaborative health management model High-risk populations for stroke Stroke awareness score Health behavior level Hospital-community-home
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Perspectives of high-risk pregnant women on home care program in high-risk pregnancies: A multicenter, qualitative study 认领 引用
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作者 Masoumeh Sayahi Shahrbanoo Salehin +2 位作者 Mehrnoosh Zakerkish Afsaneh Keramat Shahrbanoo Goli 《Asian pacific Journal of Reproduction》 CAS 2025年第1期13-20,共8页
Objective:To explore the perspectives of high-risk pregnant women regarding the home care program for high-risk pregnancies.Methods:This qualitative study was conducted in a university hospital and 5 comprehensive hea... Objective:To explore the perspectives of high-risk pregnant women regarding the home care program for high-risk pregnancies.Methods:This qualitative study was conducted in a university hospital and 5 comprehensive health centers in Ahvaz,Iran,from February 2023 to July 2023.The sampling method used was purposive sampling considering the maximum possible diversity,which continued until data saturation.11 in-depth and semistructured interviews were conducted with high-risk pregnant women.Data were simultaneously analysed using Graneheim and Lundman content analysis by MAXQDA version 20 software.Results:Data analysis extracted 3 themes,12 categories,and 26 subcategories.The themes and categories were“high-risk pregnancy and related issues(pursuing treatment and paying attention to the high-risk situation by pregnant women,psychological aspect of high-risk pregnancy on pregnant women and caregivers,emotional and physical aspects of high-risk pregnancy,the consequences of high-risk pregnancy on the people around them and empowerment of high-risk pregnant women)”,“support dimension(family and community support for high-risk pregnant women)”,and“framework of program(acculturalization,means and equipment,security,manpower and the necessary arrangements for the home care)”.Conclusions:High-risk pregnancy affects various aspects of the lives of high-risk pregnant women and their families.Creating the necessary conditions for providing care at home plays a vital role in supporting high-risk pregnant women and removing related obstacles to receiving prenatal care in person.It will be especially beneficial for high-risk pregnant women in low-income areas. 展开更多
关键词 High-risk pregnancy Home care Program Qualitative study
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Effect of nursing intervention on improving awareness of high-risk patients about stroke prevention 认领 引用
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作者 Mona M.Abd El-Maksoud Aida S.Alqarni +2 位作者 Dawlat Ahmed Mahmoud Gharib Fatma Mohammed Ahmed Eman Elsayed Hussein 《Frontiers of Nursing》 2025年第1期133-144,共12页
Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, espe... Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, especially through high-risk group. Henceforth, the aim of this study was to evaluate the effect of nursing intervention on improving awareness of high-risk people about stroke prevention. Methods: A quasi-experimental design was used to carry out this study, where a purposive sample of 80 adult patients at high risk for stroke were enrolled while they were attending the out-patient clinics of Zagazig University Hospitals for follow-up treatment;they were divided into two groups: case (40 patients) and control (40 patients). An interview questionnaire was used to assess patients’ knowledge regarding warning signs, risk factors, and immediate treatment;attitude;and their practice for prevention for stroke at pretest and posttest. Results: The study revealed the poor level of knowledge, bad level of preventive behavior, and negative attitude regarding stroke prevention at pre-intervention. However, after intervention, the high-risk people had fair level of knowledge with moderate practice for stroke prevention and positive attitude, with statistically significant difference between pre-post intervention and between the case and control groups. Conclusions: The study revealed that the nursing intervention seemed to change the knowledge, practice, and attitude of subjects regarding stroke prevention. This, in turn, implies that awareness of prevention of stroke and high-risk factor control could be important to reduce the burden of stroke in Egypt. Thus, further research on a larger scale is required to improve population knowledge and behavior for stroke prevention and control. 展开更多
关键词 awareness high-risk group intervention nursing prevention stroke
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Factors influencing loneliness in women with high-risk pregnancies and its correlation with perceived stress:a cross-sectional study 认领 引用
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作者 Jian-Tong Zhou Meng-Meng Wang Li-Hua Jin 《Nursing Communications》 2025年第26期1-9,共9页
Background:Loneliness is a common experience for pregnant women and correlates with perinatal depression and negative pregnancy outcomes.Women experiencing a high-risk pregnancy are at greater risk for loneliness beca... Background:Loneliness is a common experience for pregnant women and correlates with perinatal depression and negative pregnancy outcomes.Women experiencing a high-risk pregnancy are at greater risk for loneliness because of uncertainty with disease and the medicalization of pregnancy.International studies have identified an association between perceived stress and loneliness in pregnant women.The aim of this study is to explore factors related to loneliness among women of high-risk pregnancy,and to examine the associated relationship of loneliness and perceived stress.Methods:Using convenience sampling,109 women with high-risk pregnancies were enrolled.Data collection involved questionnaires on general demographic characteristics,the 6-item Loneliness Scale(ULS-6),and the Chinese version of the Perceived Stress Scale(CPSS-14).Data analysis was performed using SPSS 28.0 statistical software.Results:The mean loneliness score was 9.95±2.99,and the mean perceived stress score was 22.84±5.80.Women with high-risk pregnancies exhibited statistically significant differences in loneliness scores compared to the control group across among age,marital status,educational attainment,per capita monthly household income,spousal relationship,in-law relationship,and parental relationship(P<0.05).Correlation analysis revealed a positive correlation between loneliness and perceived stress(r=0.456,P<0.01).Multivariate regression analysis indicated that per capita monthly household income,marital relationship,in-law relationship,and perceived stress were the primary factors influencing loneliness among women with high-risk pregnancies(P<0.05).Conclusion:The results highlight the need for specific interventions addressing loneliness among women with high-risk pregnancies.Such interventions should focus on improving spousal and in-law relationships,reducing perceived stress,and implementing support measures,such as financial counseling or assistance programs,for those with lower per capita household income.This study establishes a foundation for the creation of integrated support systems that bring together families and healthcare providers to strengthen maternal mental health. 展开更多
关键词 high-risk pregnancy loneliness perceived stress influencing factors maternal mental health psychosocial nursing
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Application of the External Treatment Method of Traditional Chinese Medicine in the Elderly Diabetic High-Risk Foot Based on the Theory of “Preventive Treatment of Disease” 认领 引用
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作者 Meilan Li Tongping Gu +1 位作者 Jie Ji Lifeng Ma 《Journal of Clinical and Nursing Research》 2025年第5期47-59,共13页
Diabetic foot(DF)has emerged as one of the most common chronic consequences of diabetes mellitus,characterized by prolonged disease duration,high treatment costs,a poor prognosis,and a high disability rate.Diabetic hi... Diabetic foot(DF)has emerged as one of the most common chronic consequences of diabetes mellitus,characterized by prolonged disease duration,high treatment costs,a poor prognosis,and a high disability rate.Diabetic high-risk foot is the early stage of diabetic foot,the“disease prevention”of“treating no disease”,which provides a critical window for clinical prevention and treatment.Traditional Chinese medicine(TCM)has emphasized the importance of preventive health care since ancient times.External therapies such as acupuncture,massage,acupoint injection,foot bath fumigation,and moxibustion have the advantages of simplicity,low cost,precise efficacy,and fewer side effects in preventing and treating diabetic high-risk foot.The multidisciplinary synergistic model formed by TCM complementary therapies and modern medical treatments,such as nutritional,peripheral nerve,and blood glucose regulation,provides new ideas for establishing standardized prevention and treatment protocols.In this paper,studies related to TCM-related complementary therapies for diabetic high-risk feet are systematically reviewed.Current advances in external application in TCM were described to better understand its effectiveness and safety in elderly patients. 展开更多
关键词 Diabetic high-risk foot External Chinese medicine treatment method Treatment of undiagnosed disorder Review
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Research on the Application of“Internet+Continuous Nursing”in the Pregnancy Management of Pregnant Women with High-Risk Pregnancy 认领 引用
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作者 Qingyan Cheng 《Journal of Clinical and Nursing Research》 2025年第12期152-158,共7页
Pregnant women with high-risk pregnancy face a higher risk of complications due to factors such as chronic diseases,multiple pregnancies,and a history of adverse pregnancy and childbirth,requiring more systematic and ... Pregnant women with high-risk pregnancy face a higher risk of complications due to factors such as chronic diseases,multiple pregnancies,and a history of adverse pregnancy and childbirth,requiring more systematic and dynamic health management support.In view of this,“Internet+continuous nursing”can break the limitations of time and space by integrating mobile communication,remote monitoring,data sharing,and intelligent analysis technologies,realizing closed-loop care with collaboration among hospitals,communities,and families.Research shows that continuous nursing based on the“Internet+”significantly improves the professional response ability of caregivers.Medical staff can grasp the patient’s status in real time,optimize diagnosis and treatment decisions,providing a feasible path for building an efficient,precise,and humanized high-risk pregnancy management system,which has broad clinical promotion value and public health significance. 展开更多
关键词 Internet+continuous nursing Pregnant women with high-risk pregnancy Pregnancy management
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Cost-benefit analysis of esophageal cancer endoscopic screening in high-risk areas of China 认领 引用 被引量：44
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作者 Juan Yang wen-Qiang wei +3 位作者 Jin Niu Zhi-Cai Liu Chun-Xia Yang You-Lin Qiao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第20期2493-2501,共9页
AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and th... AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies. 展开更多
关键词 Cost-benefit analysis Esophageal cancer Endoscopy Screening High-risk area
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