In the natural environment,the soil structure can be weakened by temperature fluctuations and climatic changes.Nevertheless,the dynamic behavior of expansive soils,especially those with high swelling and pronounced fi...In the natural environment,the soil structure can be weakened by temperature fluctuations and climatic changes.Nevertheless,the dynamic behavior of expansive soils,especially those with high swelling and pronounced fissure properties,subjected to wetting-drying-freeze-thaw(WDFT)cycles has been rarely investigated.Undisturbed and remolded samples,made of Xinjiang’s highly expansive soils,were evaluated in this study through comprehensive resonant column tests conducted at several confining pressures and WDFT cycles.A typical hyperbolic model demonstrated the decay law of shear modulus with strain.An estimated model of the maximum shear modulus,incorporating the two factors,was developed,and it was found to be in good agreement with the measurement results.The results reveal that strain,WDFT cycle,and confining pressure have qualitatively uniform effects on the shear modulus of natural soils containing fissures and recompacted samples.However,the maximum shear modulus of the undisturbed samples is lower by 0.83–13.24 MPa due to the presence of initial fissures,except for the confining pressure of 400 kPa.Also,their responses to confining pressure are more significant,with the shear modulus increased by up to 20%–124%relative to that at 25 kPa.Furthermore,the relative difference in the shear modulus(up to about 60%)between the two samples tested under low confining pressure conditions deserves special attentions.The quantitative differences in shear modulus and cumulative damage effect of the tested samples are attributed to the initial fabric and microstructural evolution,as observed by Scanning Electron Microscope(SEM).This research enriches the theoretical framework for analyzing the ability of soils to resist shear deformation under small strain,which is instructive for disaster prevention and mitigation in expansive soil regions,considering the effects of climate change.展开更多
High-precision atomic data,including highly excited energy levels and their lifetimes,as well as autoionizing states,are essential for astrophysics,materials science,and energy research applications.Despite the increa...High-precision atomic data,including highly excited energy levels and their lifetimes,as well as autoionizing states,are essential for astrophysics,materials science,and energy research applications.Despite the increasing demand for highprecision databases,the availability of data concerning complex transition-metal atoms remains limited.In this work,we present a systematic high-precision theoretical study of highly excited and autoionizing states of the nickel atom for Jπ=4-symmetry,considering the indispensable correlation effects between bound and continuum configurations.Calculations for discrete highly excited states and autoionizing states are conducted under the same theoretical scheme,which employs the relativistic multichannel theory(RMCT),to obtain an eigenchannel scattering matrix that varies smoothly over a wide energy region.The scattering matrix is then used with the multichannel quantum defect theory(MQDT)to semi-analytically obtain highly excited states and autoionizing states.Excellent agreement is achieved between the theoretical results and existing experimental discrete levels with a maximum of 0.02%deviation.An abnormal lifetime variation of the autoionizing states along the same series is observed.The resonance energy,lifetime,and assignment of autoionizing states are systematically presented for the first time,with the objective of contributing to the fields of astrophysics,materials science,and energy research.The datasets presented in this paper,including the energy levels and lifetimes of autoionizing states,are openly available at http://gffzzd3cc09b8251d45dfsc5xpn9wbqxqf65xo.ffgz.tsg.suse.edu.cn/10.57760/sciencedb.j00113.00279.展开更多
The Qinghai-Tibet Plateau serves as a critical hub along the Central Asian Flyway(CAF)and a recognized hotspot for the emergence of highly pathogenic avian influenza(HPAI)viruses.Despite recurrent outbreaks,the migrat...The Qinghai-Tibet Plateau serves as a critical hub along the Central Asian Flyway(CAF)and a recognized hotspot for the emergence of highly pathogenic avian influenza(HPAI)viruses.Despite recurrent outbreaks,the migratory dynamics of key reservoir species,such as the Brown-headed Gull(Chroicocephalus brunnicephalus)and their potential contributions to viral dissemination remain poorly understood.Here,we integrated highresolution GPS telemetry with Bayesian discrete phylogeographic analyses to investigate the potential association between migration and HPAI H5Nx dissemination.Based on tracking data from 11 individuals,we identified 5 major life-history stages and 12 important stopover sites used during migration,including 6 in autumn and 6 in spring,and characterized their spatiotemporal distribution patterns.Phylogenetic reconstruction showed that three independent introductions of HPAI H5Nx viruses occurred on the Qinghai-Tibet Plateau between 2021 and 2024,all involving strains associated with Brown-headed Gulls and classified into the 2021-H5N8Ⅰ,2021-H5N8Ⅱ,and 2022-H5N1 clusters.These viral clusters were distributed primarily along the CAF and the East Asian–Australasian Flyway(EAAF),with diffusion patterns broadly consistent with the spatiotemporal dynamics of migratory birds.Notably,the spread of the 2022-H5N1 cluster along the CAF was highly concordant with the migratory route and phenology of Brown-headed Gulls,while host transition analysis suggested that gulls may serve as bridging hosts in interspecies transmission.Together,these findings suggest that Brown-headed Gulls may contribute to the cross-regional dissemination and interspecies transmission of HPAI H5Nx viruses,and highlight the value of combining tracking data with viral genomics for cross-border surveillance.展开更多
Wax precipitation damage caused by cold water injection or temperature reduction is very commonly seen in the development of waxy crude oil reservoirs.Various methods for eliminating wax precipitation damage have been...Wax precipitation damage caused by cold water injection or temperature reduction is very commonly seen in the development of waxy crude oil reservoirs.Various methods for eliminating wax precipitation damage have been studied by many scholars,such as injecting hot water,artificial fracture,and using chemical dewaxing agents.However,the effects of nanoemulsion on wax crystals and enhanced oil recovery(EOR)have not yet been systematically studied.This study used core displacement system based on nuclear magnetic resonance(NMR)to investigate the effect of nanoemulsion on the EOR in low-permeability,waxy oil reservoirs.Some influencing factors such as injection water temperatures,core permeability,fractured/unfractured core,and nanoemulsion concentration conditions have been investigated.Meanwhile,the wax crystal morphology and quantity have been studied before and after using nanoemulsion using a polarizing microscope.The main conclusions are as follows:(1)After injecting 60℃hot water,the recovery can be increased from 19.36%to 32.82%,which can alleviate wax deposition damage to a certain extent.(2)Enhancing core permeability or using fractured cores can increase the flow capacity of displacement fluid within the core and enhance waxy crude oil recovery.The EOR after improving core permeability is 10.22%,while the EOR of the fractured core is 26.24%.(3)Nanoemulsions can dissolve wax crystals in waxy crude oil and inhibit their formation to achieve EOR.The crude oil recovery at nanoemulsion concentrations of 0.1,0.5,and 1.0 wt%were 34.84%,38.24%,and 42.85%,respectively.(4)The use of nanoemulsion can reduce the number,area ratio,and fractal dimension of wax crystals,thereby mitigating wax deposition damage.Using a 1 wt%of nanoemulsion,the area ratio of wax crystals decreased from 47.25%to 16.67%,and the number of wax crystals decreased from 1309 to 496.展开更多
Global optimization constitutes a crucial challenge in design optimization in geotechnical engineering,which aims to maximize the performance objective function of a geotechnical engineering system,thereby achieving t...Global optimization constitutes a crucial challenge in design optimization in geotechnical engineering,which aims to maximize the performance objective function of a geotechnical engineering system,thereby achieving the optimal output.For complex geotechnical engineering systems with computationally time-consuming models and highly non-stationary responses,the direct application of stochastic optimization algorithms usually requires numerous evaluations of the original model,resulting in significantcomputational expense.To tackle this challenge,this study develops an innovative and efficientglobal optimization(EGO)method using Bayesian compressive sensing(BCS)and active learning for highly non-stationary geotechnical engineering problems,referred to as BCS-based EGO.In BCS-based EGO,BCS is utilized to train a response surface from a training sample set,enabling the efficientexecution of the stochastic optimization algorithm and providing response predictions along with the associated uncertainty at each search point.The response surface results are combined with an active learning sampling criterion to adaptively identify additional optimal sampling points,updating the response surface and training sample set to enhance the accuracy of response prediction and global optimization,until the stopping criterion of active learning is satisfied.The proposed method is capable of handling highly non-stationary data because BCS is data-driven and non-parametric.Moreover,it efficientlyaddresses the challenge of underestimating the factor of safety and failure probability in limit equilibrium method-based slope stability and reliability analysis using the potential slip surface method.Investigations utilizing three highly non-stationary benchmark examples and two highly nonstationary engineering examples indicate that BCS-based EGO performs well with sparse sampling points.展开更多
Sintering and coking are critical barriers to achieving high performance in dry reforming of methane(DRM)catalysts.A finely dispersed and thermostable Ni-based catalyst is the key to address these issues.By leveraging...Sintering and coking are critical barriers to achieving high performance in dry reforming of methane(DRM)catalysts.A finely dispersed and thermostable Ni-based catalyst is the key to address these issues.By leveraging the intrinsic superiorities of high-entropy oxides in high-temperature stability and low atomic diffusivity,in this study,a highly dispersed Ni-based catalyst is synthesized via an entropycontrolled exsolution of active components.By increasing the number of transition-metal elements in spinel oxides,the active metalsupport interaction(MSI)can be continuously strengthened,which controls the exsolution and thermal stability of Ni-based active metal in harsh reaction conditions of DRM.An optimized medium-entropy spinel(Mg0.4Ni0.2Co0.2Zn0.2)Al2O4with the exsolution of finely dispersed Ni–Co nanoparticles displayed superior activity and stability in thermal DRM at 800°C and photothermal DRM.This entropy-controlled MSI and exsolution principle provides a significant strategy for designing robust catalysts resistant to sintering and coking for high-temperature reactions like DRM in thermal and photothermal systems.展开更多
Single-wave order picking in dynamic warehouses is a sequential multi-goal navigation problem.A robot must visit an ordered set of shelves and then a delivery station while avoiding moving obstacles under partial obse...Single-wave order picking in dynamic warehouses is a sequential multi-goal navigation problem.A robot must visit an ordered set of shelves and then a delivery station while avoiding moving obstacles under partial observability.Existing approaches either entangle long-horizon task logic with low-level obstacle avoidance or rely on static-environment assumptions that limit responsiveness in dynamic settings.This paper proposes the Single-Wave Dynamic Warehouse Navigation System(SW-DWNS),a lightweight scheduling framework that extends a pretrained ColorDynamic point-to-point local planner to ordered warehouse picking without retraining.The scheduler maintains a shelf queue,exposes only the active subgoal to the local policy,and advances the queue through an arrival-gated state machine with a geometrically derived pickup threshold.We evaluate SW-DWNS in a controlled dynamic warehouse simulation benchmark with three layouts,pickup horizons K∈{1,…,5},stochastic obstacle motion,sensor noise,and obstacle-size randomization.Across the full layout-horizon grid,SW-DWNS achieves 87.3%average success,compared with 26.8%for A*search combined with the Dynamic Window Approach(A*+DWA)and 1.3%for ColorDynamic only.The gain is not obtained by sacrificing safety:the average collision rate is reduced from 69.0%for A*+DWA to 7.5%for SW-DWNS.Factor-wise ablation shows uneven robustness across disturbances:sensing noise and obstacle-size randomization have limited impact(main effects of+1 and+4.5 percentage points),whereas disabling obstacle motion costs 33 percentage points and shifts failures from collision to timeout.A pickup-threshold sweep further shows that reported success rates become inflated outside the admissible geometric bandε∈[14,31]cm.These results show that a decoupled scheduling layer can make a pretrained dynamic local planner effective for sequential warehouse picking,while also revealing the conditions under which that extension remains valid.展开更多
studies were included in the systematic review with 11 meeting the criteria for meta-analysis.Primary outcomes were complete response(no vomiting,no rescue medication)and nausea control during acute(0-24 hours),delaye...studies were included in the systematic review with 11 meeting the criteria for meta-analysis.Primary outcomes were complete response(no vomiting,no rescue medication)and nausea control during acute(0-24 hours),delayed(25-120 hours),and overall(0-120 hours)phases.Data were pooled using random-effects models.Risk of bias was assessed with Cochrane risks of bias 2.0 and risk of bias in nonrandomized studies of interventions version I tools.RESULTS Olanzapine-based regimens showed higher nausea control,with no-nausea rates of 89%vs 76%(P95%).CONCLUSION Olanzapine-based regimens are at least as effective as neurokinin-1 antagonist therapy for chemotherapy-induced nausea and vomiting in HEC,particularly for delayed nausea.Low-dose(5 mg)olanzapine provides effective,well-tolerated,oral,and cost-efficient prophylaxis,supporting its use as a first-line antiemetic.展开更多
In drug discovery,it is extremely important to identify highly potent leads with desirable drug-like profiles.Almost all the marketed phosphodiesterase 5(PDE5)inhibitors such as sildenafil,vardenafil,and tadalafil hav...In drug discovery,it is extremely important to identify highly potent leads with desirable drug-like profiles.Almost all the marketed phosphodiesterase 5(PDE5)inhibitors such as sildenafil,vardenafil,and tadalafil have poor selectivity over PDE6 or PDE11 and leading to several side effects.Herein,a metabolites-based scaffold hopping strategy was performed to discover selective PDE5 inhibitors with remarkable metabolic stability.The Eu(OTf)3-catalyzed Mannich-type reaction followed by L-selectride catalyzed reduction was used to prepare chiral 2,3,3a,4,5,6-hexahydro-1H-benzo[b]pyrido[2,3,4-de][1,6]naphthyridines as novel PDE5 inhibitors with high enantioselectivity(>99%ee and>30:1 dr).Lead L9exhibited a half maximal inhibitory concentration(IC50)of 1.03 nmol/L with higher selectivity(>898-fold)over PDE6 or PDE11 than sildenafil and tadalafil,implying the potential relief from side effects.Especially,the co-crystal binding pattern of L9 with PDE5 is revealed to be different from that of sildenafil,which possibly explain the former’s high selectivity.And oral administration of L9·HCl(5.0 mg/kg)exhibited better therapeutic effects than pirfenidone(150 mg/kg)in a bleomycin-induced idiopathic pulmonary fibrosis(IPF)rat model,highlighting the potential of L9·HCl for the treatment of IPF.展开更多
AIM:To investigate the relationship between choroidal thickness(CT)and primary open angle glaucoma(POAG)in highly myopic eyes across different categories of myopic atrophic maculopathy(MAM).METHODS:This observational ...AIM:To investigate the relationship between choroidal thickness(CT)and primary open angle glaucoma(POAG)in highly myopic eyes across different categories of myopic atrophic maculopathy(MAM).METHODS:This observational analytical case–control study enrolled highly myopic patients.All participants underwent comprehensive ophthalmic examinations.CT was measured in peripapillary and macular regions using optical coherence tomography(OCT).Each eye was classified for POAG status and MAM category.Stepwise logistic regression was performed to identify factors independently associated with POAG.RESULTS:Among 248 highly myopic subjects,37(18 males,mean age 68.25±7.16y)had POAG(25 bilateral,12 unilateral)and 211(97 males,mean age 67.09±7.63y)were non-glaucomatous.Age and sex did not differ significantly between groups(both P>0.05).Seventy-eight patients had unilateral high myopia and 170 bilateral,yielding 418 highly myopic eyes,of which 58(13.88%)had POAG.POAG prevalence across MAM categories(no lesion to complete macular atrophy)was 7.14%,16.28%,14.07%,17.86%,and 17.14%,respectively(P=0.44).In the diffuse chorioretinal atrophy subgroup,POAG eyes showed significantly thicker CT in central,inner nasal,outer superior,inner superior,and inner inferior macular regions,and thinner central corneal thickness(all P<0.05).Stepwise logistic regression showed that only parafoveal inferior CT was independently associated with POAG in this subgroup(OR=1.017;95%CI:1.005–1.028;P<0.01).No significant CT–POAG association was found in other MAM categories.CONCLUSION:Increased macular CT is independently associated with POAG in highly myopic eyes with diffuse chorioretinal atrophy.This implies distinct pathogenic mechanisms underlying POAG development across different MAM categories in high myopia.展开更多
Reducing high overpotentials in the alkaline water reduction reaction is critical for renewable hydrogen storage.Here,we report a dual-site catalytic center comprising oxygen-bridging Fe-OH and Ni-O(FeOHO-NiO)with ...Reducing high overpotentials in the alkaline water reduction reaction is critical for renewable hydrogen storage.Here,we report a dual-site catalytic center comprising oxygen-bridging Fe-OH and Ni-O(FeOHO-NiO)with Pt-like activity,where frustrated Fe-OH Lewis acid and Ni-O Lewis base generate a strong electrostatic field to promote water dissociation(Volmer step:H2O+e-→Had*+OH-).The resulting Had*adsorbs on Ni-O,forming Ni-OHad,while Fe-OH and Ni-OHad synergistically drive the Heyrovsky step(Had*+H2O+e-→*H2+OH-)to produce H2.This process achieves ultralow overpotential(52 mV@10 mA cm-2)and exceptional stability(>1000 h@300 mA cm-2),offering a design strategy for low-cost and high-performance hydrogen evolution reaction catalysts.展开更多
A review on the screening methods for the discovery of natural antimicrobial peptides Bin Yang,Hongyan Yang,Jianlong Liang,Jiarou Chen,Chunhua Wang,Yuanyuan Wang,Jincai Wang,Wenhui Luo,Tao Deng,Jialiang Guo J.Pharm.An...A review on the screening methods for the discovery of natural antimicrobial peptides Bin Yang,Hongyan Yang,Jianlong Liang,Jiarou Chen,Chunhua Wang,Yuanyuan Wang,Jincai Wang,Wenhui Luo,Tao Deng,Jialiang Guo J.Pharm.Anal.202515(1)101046 http://gffzzd3cc09b8251d45dfsc5xpn9wbqxqf65xo.ffgz.tsg.suse.edu.cn/10.1016/j.jpha.2024.101046.Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis.展开更多
Dear Editor,The highly pathogenic avian influenza viruses(HPAIVs)are important epizootic and zoonotic pathogens that cause significant economic losses to the poultry industry and pose a serious risk to veterinary and ...Dear Editor,The highly pathogenic avian influenza viruses(HPAIVs)are important epizootic and zoonotic pathogens that cause significant economic losses to the poultry industry and pose a serious risk to veterinary and public health.Wild birds have been recognized as the primary reservoirs for influenza A virus,and some species show little sign of clinical disease or even can be asymptomatic during long distance carriers of the virus(Lycett et al.,2019).Since it was first discovered in 1959,the H5Nx HPAIVs have spread globally and cause outbreaks in wild birds,poultry and sporadic human and other mammalian infections(Lycett et al.,2019).Due to the reassortant events of diverse strains facilitated by migratory waterfowl,the clade 2.3.4.4 of H5Nx viruses acquiring neuraminidase(NA)gene from other low pathogenicity avian influenza viruses(LPAIVs)emerged in 2014 and gradually became the dominant sub-clade(Lee et al.,2017).展开更多
Lithium-sulfur(Li-S)batteries hold tremendous promise for next-generation energy storage due to their high theoretical energy density and low cost.However,commercialization is hindered by severe polysulfide shuttling,...Lithium-sulfur(Li-S)batteries hold tremendous promise for next-generation energy storage due to their high theoretical energy density and low cost.However,commercialization is hindered by severe polysulfide shuttling,sluggish redox kinetics,and rapid capacity decay under practical loading conditions.Herein,we report a rationally engineered SnSe2@Ti3C2Tx MXene heterostructure as a multifunctional separator coating that synergistically combines strong Lewis acidic adsorption sites with catalytic interfaces and a highly conductive,polar-terminated MXene matrix.The SnSe2 nanosheets provide abundant catalytic centers to accelerate the redox conversion of soluble Li2Sx species,while Ti3C2Tx ensures rapid electron transport and robust chemical immobilization of polysulfide intermediates.This interfacial synergy effectively suppresses the shuttle effect,lowers electrochemical polarization,and promotes rapid charge transfer.Electrochemical evaluations reveal an initial discharge capacity of 1626 mAh g-1at 0.2 C with nearly 100%Coulombic efficiency.Under high sulfur loading(5 mg cm-2)and lean-electrolyte conditions(E/S=6μL mg-1),cells with the SnSe2@MXene-coated separator deliver 751 mAh g-1after 120 cycles,retaining 70.9%of their initial capacity.Remarkably,long-term cycling at 1 C exceeds 1000 cycles with 44.4%capacity retention and minimal structural degradation.This work demonstrates a scalable,effective separator-engineering strategy,establishing SnSe2@MXene as a promising platform for practical,high-energy-density Li-S batteries.展开更多
The booming demand for flexible electronics requires piezoelectric sensors that can simultaneously deliver high sensitivity and exceptional stretchability,which has become a significant challenge beyond the capabiliti...The booming demand for flexible electronics requires piezoelectric sensors that can simultaneously deliver high sensitivity and exceptional stretchability,which has become a significant challenge beyond the capabilities of conventional devices.Inspired by the hexagonal mesh structure,we adopted an architecture design to fabricate a continuous,structurally flexible ceramic skeleton,thereby developing a piezoelectric sensor integrating both high sensitivity and superior stretchability.The macroscopic 3D interconnected skeleton ensures efficient stress transfer for enhanced pressure sensitivity,while the hexagonal topology with hierarchical microfibers enables deformation-driven slippage under load to ensure robust stretchability.Consequently,the composite achieves remarkable stretchability(220%strain)and excellent mechanical stability(>50 stretch-compression cycles,hysteresis~8.13%).The fully flexible piezoelectric sensor maintains stable functionality even under 100%tensile strain and exhibits high sensitivity(39.57 mV kPa−1),collectively outperforming conventional piezoelectric sensors.Based on these unique advantages,we demonstrate the sensor’s capability in fine surface roughness discrimination and real-time monitoring of human stretching movements,highlighting its great potential for applications in robotic dexterous manipulation and wearable health monitoring systems.展开更多
High production volume chemicals(HPVCs)found in the environment and fish may pose health risks through dietary intake.This study measured the levels of 30 HPVCs in the ten most consumed fish species in Spain over one ...High production volume chemicals(HPVCs)found in the environment and fish may pose health risks through dietary intake.This study measured the levels of 30 HPVCs in the ten most consumed fish species in Spain over one year.The compounds with the highest average concentrations were di-(2-ethylhexyl)phthalate(740.8 ng/g dw(dry weight)),di-(2-ethylhexyl)-adipate(675.8 ng/g dw),and galaxolidone(579.0 ng/g dw).The highest intake values were recorded in Atlantic tuna,with 51.0 ng/(kg bw·day)in the high-consumption scenario.Noncarcinogenic risks were greatest for benzosulfonamides,particularly in sardine and Atlantic tuna.Carcinogenic risk factors were highest for Atlantic mackerel and tuna but remained below European Food Safety Authority safety limits,suggesting low concern for public health.Long-term monitoring provided a more accurate estimate of dietary exposure and associated health risks.展开更多
A highly sensitive,ultra-low detection limit 3-D DNA nanostructure biosensor based on functionalized reflective optical fiber probe(ROFP)is proposed and demonstrated.Our approach achieves a mass limit of detection of~...A highly sensitive,ultra-low detection limit 3-D DNA nanostructure biosensor based on functionalized reflective optical fiber probe(ROFP)is proposed and demonstrated.Our approach achieves a mass limit of detection of~10 aM based on the ROFP.A particular single-nucleotide mismatch sequence is also identified.The sensitivity of the proposed DNA biosensor is 1.51 nm/lgaM,about three-fold higher than using single-strand DNA probes(0.47 nm/lgaM)and with high specificity.The proposed ROFP has high compactness(with a length of~3 mm)which is convenient for sample detection with small volume and complex gradients in small spaces with high sensitivity.展开更多
Enhancing the performance of phosphor materials for wide-color-gamut and high-brightness phosphor-converted light-emitting diodes (pc-LEDs) represents a critical materials challenge.Improving quantum efficiency (QE) u...Enhancing the performance of phosphor materials for wide-color-gamut and high-brightness phosphor-converted light-emitting diodes (pc-LEDs) represents a critical materials challenge.Improving quantum efficiency (QE) under concentration quenching constraints and maintaining thermal stability remain primary objectives.Here,we propose a nitrogen-aluminosilicate host,La1-xSi9Al19N32(L1-xASN):x Eu2+(0.1≤x≤1.0),with a highly condensed network.Through cationic ordering and optimized local crystal field configurations under ultrahigh activator doping (x=1.0),we achieved enhanced structural rigidity that effectively suppresses nonradiative energy transfer.This strategy resulted in external quantum efficiency (EQE) increases of 332% for the x=1.0 sample relative to the x=0.5 sample,the optimal doping concentration.The high structural rigidity and artificially created nitrogen vacancy defect compensate for emission loss during the thermal generation process,improving thermal stability at x=1.0 by 278% compared to x=0.5.The designed phosphor enables pc-LEDs with a wide color gamut(106.6%NTSC) and ultrahigh brightness (8.56×106cd m-2).This study advances the understanding of the relationship between luminescent properties and microstructure,demonstrating the effectiveness of structural ordering and defect engineering in enhancing the performance of LED phosphors.展开更多
Aqueous zinc-ion batteries(AZIBs)hold promising prospects for large-scale energy storage systems,yet their commercialization is hindered by dendritic growth and water-induced side reactions associated with zinc anodes...Aqueous zinc-ion batteries(AZIBs)hold promising prospects for large-scale energy storage systems,yet their commercialization is hindered by dendritic growth and water-induced side reactions associated with zinc anodes,especially at high depths of discharge(DOD).Herein,a multifunctional zincophilic additive is developed to promote the planar Zn deposition and construct a stable solid electrolyte interphase(SEI).Disodium malate(DMA)possesses pH-buffering capability that maintains electrolyte pH stability during prolonged cycling,effectively mitigating side reactions.Furthermore,the concentration of DMA significantly influences crystal deposition.An appropriate amount of DMA molecules selectively adsorbs onto the zinc foil,facilitating uniform zinc ion deposition on the(002)crystal plane.In addition,disodium maleate molecules reconfigure the electric double layer(EDL)to reduce free water interaction and promote the in-situ formation of the dense SEI,consisting of inorganic zinc salt and amorphous organic component,on the Zn metal surface.Notably,the dense organic-inorganic hybrid SEI layer persists with remarkable structural integrity even after long cycling.These features enable a highly reversible dendritefree Zn plating/stripping process and suppress side reactions.As a result,Zn||Zn cells with DMA additives demonstrate extended cycling stability,enduring up to 5000 h at 8.6%DOD.Moreover,DMA-modified Zn anodes achieve an exceptional cycle lifespan of 750 h under 81.9%DOD with a high coulombic efficiency of 99.81%in asymmetric cells.In full-cell configurations,Zn||I2 cells stably cycle for over 12,000 cycles,retaining 89.77%of their capacity.This electrolyte regulation strategy offers a compelling pathway for the development of aqueous zinc ion batteries.展开更多
AIM:To observe the clinical features and the surgical outcomes of the high myopic(HM)patients with epiretinal membranes(ERM).METHODS:This was a retrospective study enrolled HM patients diagnosed with ERM who underwent...AIM:To observe the clinical features and the surgical outcomes of the high myopic(HM)patients with epiretinal membranes(ERM).METHODS:This was a retrospective study enrolled HM patients diagnosed with ERM who underwent vitrectomy between May 2012 and November 2021.Three groups were divided according to axial length(AXL):26–<28 mm(n=43),28–<30 mm(n=22),and≥30 mm(n=11).Baseline characteristics and postoperative visual and anatomical outcomes were analyzed.RESULTS:Totally 76 consecutive eyes of 73 HM patients(27 males),with a mean age of 60.5±9.2y(range:38–84y)were enrolled.The initial best-corrected visual acuity(BCVA)of the three groups was not significantly different(P=0.498).Longer AXL was associated with a higher incidence of both inner and outer macular retinoschisis(MRS),ellipsoid zone(EZ)disruption,and foveal retinal detachment(all P<0.05).Only the eyes in the 26–<28 mm group showed a significant improvement in postoperative BCVA.BCVA was improved in 77.6%of the eyes.Among the eyes with BCVA not improved,58.8%belonged to the group 26–<28 mm.The postoperative macular hole was seen in 1(1.32%)eye.Multivariate linear regression analysis indicated that initial BCVA(P<0.001)and epiretinal proliferation(P=0.010)influenced the final BCVA.CONCLUSION:AXL is not significantly associated with visual recovery.Early operative intervention might have better visual and anatomical outcomes in HM-ERM patients.展开更多
基金support of the National Natural Science Foundation of China(Grant No.42402290)the National Key Research and Development Program of China(Grant No.2019YFC1509901)。
摘要In the natural environment,the soil structure can be weakened by temperature fluctuations and climatic changes.Nevertheless,the dynamic behavior of expansive soils,especially those with high swelling and pronounced fissure properties,subjected to wetting-drying-freeze-thaw(WDFT)cycles has been rarely investigated.Undisturbed and remolded samples,made of Xinjiang’s highly expansive soils,were evaluated in this study through comprehensive resonant column tests conducted at several confining pressures and WDFT cycles.A typical hyperbolic model demonstrated the decay law of shear modulus with strain.An estimated model of the maximum shear modulus,incorporating the two factors,was developed,and it was found to be in good agreement with the measurement results.The results reveal that strain,WDFT cycle,and confining pressure have qualitatively uniform effects on the shear modulus of natural soils containing fissures and recompacted samples.However,the maximum shear modulus of the undisturbed samples is lower by 0.83–13.24 MPa due to the presence of initial fissures,except for the confining pressure of 400 kPa.Also,their responses to confining pressure are more significant,with the shear modulus increased by up to 20%–124%relative to that at 25 kPa.Furthermore,the relative difference in the shear modulus(up to about 60%)between the two samples tested under low confining pressure conditions deserves special attentions.The quantitative differences in shear modulus and cumulative damage effect of the tested samples are attributed to the initial fabric and microstructural evolution,as observed by Scanning Electron Microscope(SEM).This research enriches the theoretical framework for analyzing the ability of soils to resist shear deformation under small strain,which is instructive for disaster prevention and mitigation in expansive soil regions,considering the effects of climate change.
基金supported by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.12404296)the Original Exploration Program of the National Natural Science Foundation of China(Grant No.12450404)supported by the National Natural Science Foundation of China(Grant No.U2430208)。
摘要High-precision atomic data,including highly excited energy levels and their lifetimes,as well as autoionizing states,are essential for astrophysics,materials science,and energy research applications.Despite the increasing demand for highprecision databases,the availability of data concerning complex transition-metal atoms remains limited.In this work,we present a systematic high-precision theoretical study of highly excited and autoionizing states of the nickel atom for Jπ=4-symmetry,considering the indispensable correlation effects between bound and continuum configurations.Calculations for discrete highly excited states and autoionizing states are conducted under the same theoretical scheme,which employs the relativistic multichannel theory(RMCT),to obtain an eigenchannel scattering matrix that varies smoothly over a wide energy region.The scattering matrix is then used with the multichannel quantum defect theory(MQDT)to semi-analytically obtain highly excited states and autoionizing states.Excellent agreement is achieved between the theoretical results and existing experimental discrete levels with a maximum of 0.02%deviation.An abnormal lifetime variation of the autoionizing states along the same series is observed.The resonance energy,lifetime,and assignment of autoionizing states are systematically presented for the first time,with the objective of contributing to the fields of astrophysics,materials science,and energy research.The datasets presented in this paper,including the energy levels and lifetimes of autoionizing states,are openly available at http://gffzzd3cc09b8251d45dfsc5xpn9wbqxqf65xo.ffgz.tsg.suse.edu.cn/10.57760/sciencedb.j00113.00279.
基金supported by Heilongjiang Provincial Natural Science Foundation of China(ZL2025H001)National Natural Science Foundation of China(32500447)+3 种基金Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project(2025ZD01900100)Major Project of Guangzhou National Laboratory(GZNL2023A01001)State Key Laboratory for Animal Disease Control and Prevention Foundation(SKLADCPKF2024XX)the National Forestry and Grassland Administration,China。
摘要The Qinghai-Tibet Plateau serves as a critical hub along the Central Asian Flyway(CAF)and a recognized hotspot for the emergence of highly pathogenic avian influenza(HPAI)viruses.Despite recurrent outbreaks,the migratory dynamics of key reservoir species,such as the Brown-headed Gull(Chroicocephalus brunnicephalus)and their potential contributions to viral dissemination remain poorly understood.Here,we integrated highresolution GPS telemetry with Bayesian discrete phylogeographic analyses to investigate the potential association between migration and HPAI H5Nx dissemination.Based on tracking data from 11 individuals,we identified 5 major life-history stages and 12 important stopover sites used during migration,including 6 in autumn and 6 in spring,and characterized their spatiotemporal distribution patterns.Phylogenetic reconstruction showed that three independent introductions of HPAI H5Nx viruses occurred on the Qinghai-Tibet Plateau between 2021 and 2024,all involving strains associated with Brown-headed Gulls and classified into the 2021-H5N8Ⅰ,2021-H5N8Ⅱ,and 2022-H5N1 clusters.These viral clusters were distributed primarily along the CAF and the East Asian–Australasian Flyway(EAAF),with diffusion patterns broadly consistent with the spatiotemporal dynamics of migratory birds.Notably,the spread of the 2022-H5N1 cluster along the CAF was highly concordant with the migratory route and phenology of Brown-headed Gulls,while host transition analysis suggested that gulls may serve as bridging hosts in interspecies transmission.Together,these findings suggest that Brown-headed Gulls may contribute to the cross-regional dissemination and interspecies transmission of HPAI H5Nx viruses,and highlight the value of combining tracking data with viral genomics for cross-border surveillance.
基金supported by the National Science and Technology Major Project(2017ZX05009-005-003)the National Natural Science Foundation of China(U23B2084)。
摘要Wax precipitation damage caused by cold water injection or temperature reduction is very commonly seen in the development of waxy crude oil reservoirs.Various methods for eliminating wax precipitation damage have been studied by many scholars,such as injecting hot water,artificial fracture,and using chemical dewaxing agents.However,the effects of nanoemulsion on wax crystals and enhanced oil recovery(EOR)have not yet been systematically studied.This study used core displacement system based on nuclear magnetic resonance(NMR)to investigate the effect of nanoemulsion on the EOR in low-permeability,waxy oil reservoirs.Some influencing factors such as injection water temperatures,core permeability,fractured/unfractured core,and nanoemulsion concentration conditions have been investigated.Meanwhile,the wax crystal morphology and quantity have been studied before and after using nanoemulsion using a polarizing microscope.The main conclusions are as follows:(1)After injecting 60℃hot water,the recovery can be increased from 19.36%to 32.82%,which can alleviate wax deposition damage to a certain extent.(2)Enhancing core permeability or using fractured cores can increase the flow capacity of displacement fluid within the core and enhance waxy crude oil recovery.The EOR after improving core permeability is 10.22%,while the EOR of the fractured core is 26.24%.(3)Nanoemulsions can dissolve wax crystals in waxy crude oil and inhibit their formation to achieve EOR.The crude oil recovery at nanoemulsion concentrations of 0.1,0.5,and 1.0 wt%were 34.84%,38.24%,and 42.85%,respectively.(4)The use of nanoemulsion can reduce the number,area ratio,and fractal dimension of wax crystals,thereby mitigating wax deposition damage.Using a 1 wt%of nanoemulsion,the area ratio of wax crystals decreased from 47.25%to 16.67%,and the number of wax crystals decreased from 1309 to 496.
基金financially supported by the National Natural Science Foundation of China(Grant No.52578420,52278363)Shenzhen Science and Technology Program(Grant No.KQTD20221101093555006).
摘要Global optimization constitutes a crucial challenge in design optimization in geotechnical engineering,which aims to maximize the performance objective function of a geotechnical engineering system,thereby achieving the optimal output.For complex geotechnical engineering systems with computationally time-consuming models and highly non-stationary responses,the direct application of stochastic optimization algorithms usually requires numerous evaluations of the original model,resulting in significantcomputational expense.To tackle this challenge,this study develops an innovative and efficientglobal optimization(EGO)method using Bayesian compressive sensing(BCS)and active learning for highly non-stationary geotechnical engineering problems,referred to as BCS-based EGO.In BCS-based EGO,BCS is utilized to train a response surface from a training sample set,enabling the efficientexecution of the stochastic optimization algorithm and providing response predictions along with the associated uncertainty at each search point.The response surface results are combined with an active learning sampling criterion to adaptively identify additional optimal sampling points,updating the response surface and training sample set to enhance the accuracy of response prediction and global optimization,until the stopping criterion of active learning is satisfied.The proposed method is capable of handling highly non-stationary data because BCS is data-driven and non-parametric.Moreover,it efficientlyaddresses the challenge of underestimating the factor of safety and failure probability in limit equilibrium method-based slope stability and reliability analysis using the potential slip surface method.Investigations utilizing three highly non-stationary benchmark examples and two highly nonstationary engineering examples indicate that BCS-based EGO performs well with sparse sampling points.
基金supported by the National Key R&D Program of China(2023YFB4104600)National Natural Science Foundation of China(52572313)+1 种基金Tangshan Talent Funding Project(A202202007)Shenzhen Science and Technology Innovation Commission under Grant No.20231120185819001。
摘要Sintering and coking are critical barriers to achieving high performance in dry reforming of methane(DRM)catalysts.A finely dispersed and thermostable Ni-based catalyst is the key to address these issues.By leveraging the intrinsic superiorities of high-entropy oxides in high-temperature stability and low atomic diffusivity,in this study,a highly dispersed Ni-based catalyst is synthesized via an entropycontrolled exsolution of active components.By increasing the number of transition-metal elements in spinel oxides,the active metalsupport interaction(MSI)can be continuously strengthened,which controls the exsolution and thermal stability of Ni-based active metal in harsh reaction conditions of DRM.An optimized medium-entropy spinel(Mg0.4Ni0.2Co0.2Zn0.2)Al2O4with the exsolution of finely dispersed Ni–Co nanoparticles displayed superior activity and stability in thermal DRM at 800°C and photothermal DRM.This entropy-controlled MSI and exsolution principle provides a significant strategy for designing robust catalysts resistant to sintering and coking for high-temperature reactions like DRM in thermal and photothermal systems.
摘要Single-wave order picking in dynamic warehouses is a sequential multi-goal navigation problem.A robot must visit an ordered set of shelves and then a delivery station while avoiding moving obstacles under partial observability.Existing approaches either entangle long-horizon task logic with low-level obstacle avoidance or rely on static-environment assumptions that limit responsiveness in dynamic settings.This paper proposes the Single-Wave Dynamic Warehouse Navigation System(SW-DWNS),a lightweight scheduling framework that extends a pretrained ColorDynamic point-to-point local planner to ordered warehouse picking without retraining.The scheduler maintains a shelf queue,exposes only the active subgoal to the local policy,and advances the queue through an arrival-gated state machine with a geometrically derived pickup threshold.We evaluate SW-DWNS in a controlled dynamic warehouse simulation benchmark with three layouts,pickup horizons K∈{1,…,5},stochastic obstacle motion,sensor noise,and obstacle-size randomization.Across the full layout-horizon grid,SW-DWNS achieves 87.3%average success,compared with 26.8%for A*search combined with the Dynamic Window Approach(A*+DWA)and 1.3%for ColorDynamic only.The gain is not obtained by sacrificing safety:the average collision rate is reduced from 69.0%for A*+DWA to 7.5%for SW-DWNS.Factor-wise ablation shows uneven robustness across disturbances:sensing noise and obstacle-size randomization have limited impact(main effects of+1 and+4.5 percentage points),whereas disabling obstacle motion costs 33 percentage points and shifts failures from collision to timeout.A pickup-threshold sweep further shows that reported success rates become inflated outside the admissible geometric bandε∈[14,31]cm.These results show that a decoupled scheduling layer can make a pretrained dynamic local planner effective for sequential warehouse picking,while also revealing the conditions under which that extension remains valid.
摘要studies were included in the systematic review with 11 meeting the criteria for meta-analysis.Primary outcomes were complete response(no vomiting,no rescue medication)and nausea control during acute(0-24 hours),delayed(25-120 hours),and overall(0-120 hours)phases.Data were pooled using random-effects models.Risk of bias was assessed with Cochrane risks of bias 2.0 and risk of bias in nonrandomized studies of interventions version I tools.RESULTS Olanzapine-based regimens showed higher nausea control,with no-nausea rates of 89%vs 76%(P95%).CONCLUSION Olanzapine-based regimens are at least as effective as neurokinin-1 antagonist therapy for chemotherapy-induced nausea and vomiting in HEC,particularly for delayed nausea.Low-dose(5 mg)olanzapine provides effective,well-tolerated,oral,and cost-efficient prophylaxis,supporting its use as a first-line antiemetic.
基金financial support from the Natural Science Foundation of China(Nos.82373732,22377023,22307031,81872727)Excellent Talent Team Project in Hainan Province(No.HNYT20250004)+1 种基金Hainan Provincial Natural Science Foundation of China(Nos.KJRC2023B10,222RC556,823CXTD375,324MS018)Fundamental Research Funds for Hainan University(Nos.XTCX2022JKA01,KYQD(ZR)-21126,KYQD(ZR)-23003)。
摘要In drug discovery,it is extremely important to identify highly potent leads with desirable drug-like profiles.Almost all the marketed phosphodiesterase 5(PDE5)inhibitors such as sildenafil,vardenafil,and tadalafil have poor selectivity over PDE6 or PDE11 and leading to several side effects.Herein,a metabolites-based scaffold hopping strategy was performed to discover selective PDE5 inhibitors with remarkable metabolic stability.The Eu(OTf)3-catalyzed Mannich-type reaction followed by L-selectride catalyzed reduction was used to prepare chiral 2,3,3a,4,5,6-hexahydro-1H-benzo[b]pyrido[2,3,4-de][1,6]naphthyridines as novel PDE5 inhibitors with high enantioselectivity(>99%ee and>30:1 dr).Lead L9exhibited a half maximal inhibitory concentration(IC50)of 1.03 nmol/L with higher selectivity(>898-fold)over PDE6 or PDE11 than sildenafil and tadalafil,implying the potential relief from side effects.Especially,the co-crystal binding pattern of L9 with PDE5 is revealed to be different from that of sildenafil,which possibly explain the former’s high selectivity.And oral administration of L9·HCl(5.0 mg/kg)exhibited better therapeutic effects than pirfenidone(150 mg/kg)in a bleomycin-induced idiopathic pulmonary fibrosis(IPF)rat model,highlighting the potential of L9·HCl for the treatment of IPF.
基金Supported by National Natural Science Foundation of China(No.82101181)Science and Technology Commission of Shanghai Municipality(No.19YF1439700)Shanghai Eye Disease Prevention and Treatment Center(No.QX-2023-A-011,No.QX-2023-A-012,No.QX-2024-A-018).
摘要AIM:To investigate the relationship between choroidal thickness(CT)and primary open angle glaucoma(POAG)in highly myopic eyes across different categories of myopic atrophic maculopathy(MAM).METHODS:This observational analytical case–control study enrolled highly myopic patients.All participants underwent comprehensive ophthalmic examinations.CT was measured in peripapillary and macular regions using optical coherence tomography(OCT).Each eye was classified for POAG status and MAM category.Stepwise logistic regression was performed to identify factors independently associated with POAG.RESULTS:Among 248 highly myopic subjects,37(18 males,mean age 68.25±7.16y)had POAG(25 bilateral,12 unilateral)and 211(97 males,mean age 67.09±7.63y)were non-glaucomatous.Age and sex did not differ significantly between groups(both P>0.05).Seventy-eight patients had unilateral high myopia and 170 bilateral,yielding 418 highly myopic eyes,of which 58(13.88%)had POAG.POAG prevalence across MAM categories(no lesion to complete macular atrophy)was 7.14%,16.28%,14.07%,17.86%,and 17.14%,respectively(P=0.44).In the diffuse chorioretinal atrophy subgroup,POAG eyes showed significantly thicker CT in central,inner nasal,outer superior,inner superior,and inner inferior macular regions,and thinner central corneal thickness(all P<0.05).Stepwise logistic regression showed that only parafoveal inferior CT was independently associated with POAG in this subgroup(OR=1.017;95%CI:1.005–1.028;P<0.01).No significant CT–POAG association was found in other MAM categories.CONCLUSION:Increased macular CT is independently associated with POAG in highly myopic eyes with diffuse chorioretinal atrophy.This implies distinct pathogenic mechanisms underlying POAG development across different MAM categories in high myopia.
基金supported primarily by the Scientific and Technological Innovation Project of Carbon Emission Peak and Carbon Neutrality of Jiangsu Province(No.BE2022028-1)the National Natural Science Foundation of China(Grant Nos 52272217,51872135,22372078,51572121,and 21633004)。
摘要Reducing high overpotentials in the alkaline water reduction reaction is critical for renewable hydrogen storage.Here,we report a dual-site catalytic center comprising oxygen-bridging Fe-OH and Ni-O(FeOHO-NiO)with Pt-like activity,where frustrated Fe-OH Lewis acid and Ni-O Lewis base generate a strong electrostatic field to promote water dissociation(Volmer step:H2O+e-→Had*+OH-).The resulting Had*adsorbs on Ni-O,forming Ni-OHad,while Fe-OH and Ni-OHad synergistically drive the Heyrovsky step(Had*+H2O+e-→*H2+OH-)to produce H2.This process achieves ultralow overpotential(52 mV@10 mA cm-2)and exceptional stability(>1000 h@300 mA cm-2),offering a design strategy for low-cost and high-performance hydrogen evolution reaction catalysts.
摘要A review on the screening methods for the discovery of natural antimicrobial peptides Bin Yang,Hongyan Yang,Jianlong Liang,Jiarou Chen,Chunhua Wang,Yuanyuan Wang,Jincai Wang,Wenhui Luo,Tao Deng,Jialiang Guo J.Pharm.Anal.202515(1)101046 http://gffzzd3cc09b8251d45dfsc5xpn9wbqxqf65xo.ffgz.tsg.suse.edu.cn/10.1016/j.jpha.2024.101046.Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis.
基金supported by Zhejiang Province Science and Technology Cooperation Project of“Three Rural and Nine Parties”(grant number 2023SNJF059).
摘要Dear Editor,The highly pathogenic avian influenza viruses(HPAIVs)are important epizootic and zoonotic pathogens that cause significant economic losses to the poultry industry and pose a serious risk to veterinary and public health.Wild birds have been recognized as the primary reservoirs for influenza A virus,and some species show little sign of clinical disease or even can be asymptomatic during long distance carriers of the virus(Lycett et al.,2019).Since it was first discovered in 1959,the H5Nx HPAIVs have spread globally and cause outbreaks in wild birds,poultry and sporadic human and other mammalian infections(Lycett et al.,2019).Due to the reassortant events of diverse strains facilitated by migratory waterfowl,the clade 2.3.4.4 of H5Nx viruses acquiring neuraminidase(NA)gene from other low pathogenicity avian influenza viruses(LPAIVs)emerged in 2014 and gradually became the dominant sub-clade(Lee et al.,2017).
基金funded by the National Science Foundation under grants CBET-2427263 and TI-2147564.
摘要Lithium-sulfur(Li-S)batteries hold tremendous promise for next-generation energy storage due to their high theoretical energy density and low cost.However,commercialization is hindered by severe polysulfide shuttling,sluggish redox kinetics,and rapid capacity decay under practical loading conditions.Herein,we report a rationally engineered SnSe2@Ti3C2Tx MXene heterostructure as a multifunctional separator coating that synergistically combines strong Lewis acidic adsorption sites with catalytic interfaces and a highly conductive,polar-terminated MXene matrix.The SnSe2 nanosheets provide abundant catalytic centers to accelerate the redox conversion of soluble Li2Sx species,while Ti3C2Tx ensures rapid electron transport and robust chemical immobilization of polysulfide intermediates.This interfacial synergy effectively suppresses the shuttle effect,lowers electrochemical polarization,and promotes rapid charge transfer.Electrochemical evaluations reveal an initial discharge capacity of 1626 mAh g-1at 0.2 C with nearly 100%Coulombic efficiency.Under high sulfur loading(5 mg cm-2)and lean-electrolyte conditions(E/S=6μL mg-1),cells with the SnSe2@MXene-coated separator deliver 751 mAh g-1after 120 cycles,retaining 70.9%of their initial capacity.Remarkably,long-term cycling at 1 C exceeds 1000 cycles with 44.4%capacity retention and minimal structural degradation.This work demonstrates a scalable,effective separator-engineering strategy,establishing SnSe2@MXene as a promising platform for practical,high-energy-density Li-S batteries.
基金supported by the National Key Research and Development Program of China(No.2024YFB3815800 and No.2024YFB3815801)the National Natural Scientific Foundation of China(No.62474107).
摘要The booming demand for flexible electronics requires piezoelectric sensors that can simultaneously deliver high sensitivity and exceptional stretchability,which has become a significant challenge beyond the capabilities of conventional devices.Inspired by the hexagonal mesh structure,we adopted an architecture design to fabricate a continuous,structurally flexible ceramic skeleton,thereby developing a piezoelectric sensor integrating both high sensitivity and superior stretchability.The macroscopic 3D interconnected skeleton ensures efficient stress transfer for enhanced pressure sensitivity,while the hexagonal topology with hierarchical microfibers enables deformation-driven slippage under load to ensure robust stretchability.Consequently,the composite achieves remarkable stretchability(220%strain)and excellent mechanical stability(>50 stretch-compression cycles,hysteresis~8.13%).The fully flexible piezoelectric sensor maintains stable functionality even under 100%tensile strain and exhibits high sensitivity(39.57 mV kPa−1),collectively outperforming conventional piezoelectric sensors.Based on these unique advantages,we demonstrate the sensor’s capability in fine surface roughness discrimination and real-time monitoring of human stretching movements,highlighting its great potential for applications in robotic dexterous manipulation and wearable health monitoring systems.
基金supported by the project PID2020–114587GB-I00 funded by MCIN/AEI/10.13039/501100011033Agència de Gestiód’Ajudes Universitàries i Recerca(AGAUR)(No.2021 FISDU 00070)。
摘要High production volume chemicals(HPVCs)found in the environment and fish may pose health risks through dietary intake.This study measured the levels of 30 HPVCs in the ten most consumed fish species in Spain over one year.The compounds with the highest average concentrations were di-(2-ethylhexyl)phthalate(740.8 ng/g dw(dry weight)),di-(2-ethylhexyl)-adipate(675.8 ng/g dw),and galaxolidone(579.0 ng/g dw).The highest intake values were recorded in Atlantic tuna,with 51.0 ng/(kg bw·day)in the high-consumption scenario.Noncarcinogenic risks were greatest for benzosulfonamides,particularly in sardine and Atlantic tuna.Carcinogenic risk factors were highest for Atlantic mackerel and tuna but remained below European Food Safety Authority safety limits,suggesting low concern for public health.Long-term monitoring provided a more accurate estimate of dietary exposure and associated health risks.
基金supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant Nos.25KJB416001 and 22KJB510034)the National Natural Science Foundation of China(Grant Nos.12174199 and 11704199)+5 种基金the Scientific Research Foundation for Highlevel Talents in Nanjing Vocational College of Information Technology(Grant No.YB202410)the China Postdoctoral Science Foundation(Grant No.2021M701765)General Program of Natural Science Foundation of Jiangsu Province(Grant No.BK20221330)Jiangsu University‘Blue Project’FundingPostgraduate Research&Practice Innovation Programs of Jiangsu ProvinceJiangsu Province Higher Education Teaching Reform Research Project(Grant No.2025JGYB487)。
摘要A highly sensitive,ultra-low detection limit 3-D DNA nanostructure biosensor based on functionalized reflective optical fiber probe(ROFP)is proposed and demonstrated.Our approach achieves a mass limit of detection of~10 aM based on the ROFP.A particular single-nucleotide mismatch sequence is also identified.The sensitivity of the proposed DNA biosensor is 1.51 nm/lgaM,about three-fold higher than using single-strand DNA probes(0.47 nm/lgaM)and with high specificity.The proposed ROFP has high compactness(with a length of~3 mm)which is convenient for sample detection with small volume and complex gradients in small spaces with high sensitivity.
基金financially supported by the National Natural Science Foundation of China(Grant No.523B2014)the National Key R&D Program of China(Grant Nos.2023YFB3506600 and 2023YFB3506601)。
摘要Enhancing the performance of phosphor materials for wide-color-gamut and high-brightness phosphor-converted light-emitting diodes (pc-LEDs) represents a critical materials challenge.Improving quantum efficiency (QE) under concentration quenching constraints and maintaining thermal stability remain primary objectives.Here,we propose a nitrogen-aluminosilicate host,La1-xSi9Al19N32(L1-xASN):x Eu2+(0.1≤x≤1.0),with a highly condensed network.Through cationic ordering and optimized local crystal field configurations under ultrahigh activator doping (x=1.0),we achieved enhanced structural rigidity that effectively suppresses nonradiative energy transfer.This strategy resulted in external quantum efficiency (EQE) increases of 332% for the x=1.0 sample relative to the x=0.5 sample,the optimal doping concentration.The high structural rigidity and artificially created nitrogen vacancy defect compensate for emission loss during the thermal generation process,improving thermal stability at x=1.0 by 278% compared to x=0.5.The designed phosphor enables pc-LEDs with a wide color gamut(106.6%NTSC) and ultrahigh brightness (8.56×106cd m-2).This study advances the understanding of the relationship between luminescent properties and microstructure,demonstrating the effectiveness of structural ordering and defect engineering in enhancing the performance of LED phosphors.
基金financial support from the National Science Fund for Distinguished Young Scholars(No.52225312)the Natural Science Foundation of Zhejiang Province(No.LMS25E020002,LY24B030008)+1 种基金the National Natural Science Foundation of China(Nos.52002101,52272292,and 2209032)supported by computational resources provided by the Australian Government through Gadi under the National Computa-tional Merit Allocation Scheme and was accessed through the SIH HPC Allocation Scheme(No.LE190100021).
摘要Aqueous zinc-ion batteries(AZIBs)hold promising prospects for large-scale energy storage systems,yet their commercialization is hindered by dendritic growth and water-induced side reactions associated with zinc anodes,especially at high depths of discharge(DOD).Herein,a multifunctional zincophilic additive is developed to promote the planar Zn deposition and construct a stable solid electrolyte interphase(SEI).Disodium malate(DMA)possesses pH-buffering capability that maintains electrolyte pH stability during prolonged cycling,effectively mitigating side reactions.Furthermore,the concentration of DMA significantly influences crystal deposition.An appropriate amount of DMA molecules selectively adsorbs onto the zinc foil,facilitating uniform zinc ion deposition on the(002)crystal plane.In addition,disodium maleate molecules reconfigure the electric double layer(EDL)to reduce free water interaction and promote the in-situ formation of the dense SEI,consisting of inorganic zinc salt and amorphous organic component,on the Zn metal surface.Notably,the dense organic-inorganic hybrid SEI layer persists with remarkable structural integrity even after long cycling.These features enable a highly reversible dendritefree Zn plating/stripping process and suppress side reactions.As a result,Zn||Zn cells with DMA additives demonstrate extended cycling stability,enduring up to 5000 h at 8.6%DOD.Moreover,DMA-modified Zn anodes achieve an exceptional cycle lifespan of 750 h under 81.9%DOD with a high coulombic efficiency of 99.81%in asymmetric cells.In full-cell configurations,Zn||I2 cells stably cycle for over 12,000 cycles,retaining 89.77%of their capacity.This electrolyte regulation strategy offers a compelling pathway for the development of aqueous zinc ion batteries.
基金Supported by National Natural Science Foundation of China(No.82401269).
摘要AIM:To observe the clinical features and the surgical outcomes of the high myopic(HM)patients with epiretinal membranes(ERM).METHODS:This was a retrospective study enrolled HM patients diagnosed with ERM who underwent vitrectomy between May 2012 and November 2021.Three groups were divided according to axial length(AXL):26–<28 mm(n=43),28–<30 mm(n=22),and≥30 mm(n=11).Baseline characteristics and postoperative visual and anatomical outcomes were analyzed.RESULTS:Totally 76 consecutive eyes of 73 HM patients(27 males),with a mean age of 60.5±9.2y(range:38–84y)were enrolled.The initial best-corrected visual acuity(BCVA)of the three groups was not significantly different(P=0.498).Longer AXL was associated with a higher incidence of both inner and outer macular retinoschisis(MRS),ellipsoid zone(EZ)disruption,and foveal retinal detachment(all P<0.05).Only the eyes in the 26–<28 mm group showed a significant improvement in postoperative BCVA.BCVA was improved in 77.6%of the eyes.Among the eyes with BCVA not improved,58.8%belonged to the group 26–<28 mm.The postoperative macular hole was seen in 1(1.32%)eye.Multivariate linear regression analysis indicated that initial BCVA(P<0.001)and epiretinal proliferation(P=0.010)influenced the final BCVA.CONCLUSION:AXL is not significantly associated with visual recovery.Early operative intervention might have better visual and anatomical outcomes in HM-ERM patients.