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Melatonin-Mediated Coordination of ROS Signaling,Physiological,and Hormonal Networks under Drought Stress 认领 引用
1
作者 Hossam S.El-Beltagi Tarek A.Shalaby +1 位作者 Nagwa Khedr Emad H.Khedr 《Phyton-International Journal of Experimental Botany》 SCIE 2026年第7期1-27,共27页
Drought stress stands out as a main abiotic factor that adversely influences the development,yield,and quality of plants.With the increasing prevalence of water scarcity driven by climate change,urban expansion,and in... Drought stress stands out as a main abiotic factor that adversely influences the development,yield,and quality of plants.With the increasing prevalence of water scarcity driven by climate change,urban expansion,and industrial activities,understanding plant responses to limited water availability has become critically important.Among stress-related molecules,melatonin has gained recognition as a multipurpose regulator with a central role in strengthening plant tolerance to drought.The synthesis and accumulation of melatonin are influenced by environmental stressors and vary across plant species and tissue types.Whether synthesized internally or applied externally,melatonin contributes to drought mitigation by neutralizing reactive oxygen species(ROS),boosting the activity of enzymatic antioxidants,and modulating levels of non-enzymatic defense compounds.Additionally,it regulates stress-responsive genes and activates defense pathways intermediated by key phytohormones such as abscisic acid(ABA),salicylic,and gibberellins.Melatonin’s interaction with other hormonal signals including auxins,cytokinins,jasmonates,and ethylene creates a dynamic network of hormonal crosstalk that further strengthens plant tolerance mechanisms.Its beneficial effects are evident in improved photosynthetic efficiency,optimized stomatal behavior,enhanced seed germination,and stimulated root development.This review focus on the effects of melatonin in plants under drought conditions,highlighting its interplay with other signaling molecules and hormonal pathways.It further highlights recent progress and strategic approaches for utilizing melatonin in developing drought-resilient cultivars and enhancing agricultural sustainability. 展开更多
关键词 Bio-stimulants hormonal crosstalk photosynthesis growth regulators plant resilience water scarcity
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Decoding the cold signal:hormonal networks orchestrating the trade-off between growth and tolerance 认领 引用
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作者 Jingwen Ye Chunlan Yu Yanru Hu 《Tropical Plants》 CSCD 2026年第1期61-74,共14页
Low-temperature(LT)stress represents a pivotal environmental factor that significantly impacts plant growth,geographical distribution,and agricultural productivity.As sessile organisms,plants have evolved a suite of s... Low-temperature(LT)stress represents a pivotal environmental factor that significantly impacts plant growth,geographical distribution,and agricultural productivity.As sessile organisms,plants have evolved a suite of sophisticated mechanisms to adapt to LT environments,achieving an optimal balance between growth and cold tolerance,a phenomenon termed the growth and tolerance trade-off.This balance is not a passive outcome but rather an active,dynamic,and adaptive decision-making process regulated by a complex molecular network.This review systematically summarizes the molecular mechanisms underlying plant responses to LT and the equilibrium between growth and cold tolerance,with a particular emphasis on LT perception and signal transduction,the suppression of growth and developmental processes,and the regulatory role of hormonal networks.It underscores the central role of hormonal signaling networks in balancing cold tolerance and growth,and also explores potential future applications in this field. 展开更多
关键词 developmental processes low temperature stress agricultural productivity hormonal networks signal transduction plant adaptation molecular mechanisms cold signal
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Dual function of GbNAC2 in flavonoid metabolism and hormonal pathways enhances salt tolerance in Ginkgo biloba 认领 引用 被引量：1
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作者 Jinkai Lu Han Tang +6 位作者 Wei Li Yanbin Jiang Helin Zou Zhili Wang Weixing Li Qingjie Wang Li Wang 《Forestry Research》 2025年第1期39-49,共11页
NAC transcription factors are central regulators of plant salt tolerance,yet their specific roles in ginkgo salt response remain unclear.Here,GbNAC2 was identified as a salinity-induced transcriptional activator in gi... NAC transcription factors are central regulators of plant salt tolerance,yet their specific roles in ginkgo salt response remain unclear.Here,GbNAC2 was identified as a salinity-induced transcriptional activator in ginkgo,orchestrating two key adaptive responses.GbNAC2 overexpression significantly improved salt tolerance in transgenic plants,accompanied by over 60%increase in root length,and more than 20%increase in flavonoid content compared to wild type(WT).Transcriptome analysis of GbNAC2-overexpressing ginkgo calli revealed that genes related to auxin biosynthesis,and those involved in the flavonoid synthesis pathway,were significantly upregulated in transgenic calli.Mechanistically,GbNAC2 directly binds the GbAREB3 promoter to enhance ABA signaling,and exogenous ABA treatment further enhances salt resilience.The present findings unveil a unique crosstalk mediated by GbNAC2 between flavonoid-antioxidant systems and auxin-ABA hormonal networks,effectively resolving the growth-defense trade-off under salinity in ginkgo. 展开更多
关键词 flavonoid metabolism dual function nac transcription factors hormonal pathways adaptive responsesgbnac salt tolerance GBNAC transgenic plantsaccompanied
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Comparative hormonal and transcriptomic analysis of heat stress responses in cassava and potato 认领 引用
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作者 Jia Luo Jin Xiao +3 位作者 Haozheng Li Shujuan Wang Wenquan Wang Xin Guo 《Tropical Plants》 CSCD 2025年第1期47-59,共13页
Improving crop heat tolerance is essential under the increasingly frequent extreme temperature conditions worldwide.Cassava(Manihot esculenta Crantz)is a tropical crop with strong resistance to high temperature and hi... Improving crop heat tolerance is essential under the increasingly frequent extreme temperature conditions worldwide.Cassava(Manihot esculenta Crantz)is a tropical crop with strong resistance to high temperature and high light,whereas potato(Solanum tuberosum L.)is a temperate crop highly sensitive to heat stress.To elucidate the differences in heat stress responses between cassava and potato,this study combined transcriptome sequencing with hormonal profiling.The results revealed that cassava exhibited significant changes in hormone signaling with relatively lower amplitude,whereas potato showed large fluctuations in both hormone levels and signaling pathways.Transcriptome analysis identified numerous differentially expressed genes(DEGs)in cassava cultivars KU50 and SC205 and in potato cultivars FAVORITA and Qingshu No.9.Weighted gene co-expression network analysis(WGCNA)identified 13 regulatory modules in cassava and 11 in potato.In cassava,heat-responsive transcription factors and heat shock proteins(HSPs)were generally downregulated,while genes involved in photosynthetic electron transport and lignin biosynthesis were upregulated;the opposite trend was observed in potato.RT-qPCR validation confirmed the transcriptome data.These findings provide valuable gene resources for breeding heat-tolerant crop varieties and offer insights into the molecular mechanisms underlying heat tolerance in tropical vs temperate crops. 展开更多
关键词 cassava transcriptome sequencing hormonal profilingthe differences heat stress responses transcriptomic analysis hormonal profiling heat stress improving crop heat tolerance
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Impact of long-term environmental toxin exposure on prepubertal boys'anthropometric and hormonal development 认领 引用
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作者 Valery Erkudov Kenjabek Rozumbetov +4 位作者 Shanika Arachchi Upaka Rathnayake Azat Matchanov Andrey Pugovkin Sergey Lytaev 《Global Health Journal》 CAS 2025年第3期238-247,共10页
Background:Long-term exposure to toxic substances increases the risk of their accumulation and triggering endocrine disruption.The ill-planned irrigation systems in Uzbekistan led to severe environmental disasters,res... Background:Long-term exposure to toxic substances increases the risk of their accumulation and triggering endocrine disruption.The ill-planned irrigation systems in Uzbekistan led to severe environmental disasters,resulting in aridization and the spread of organochlorine pesticides and toxic metals across the region.Objective:We investigate the influence of negative environmental factors on hormonal activities such as sex steroids,gonadotropic hormones,and growth factors,in addition to potential disruptions in growth rate and anthropometric indicators in prepubertal adolescents living in this region.Methods:This study included 405 prepubertal boys aged 11 to 13 years,residing in the cities of Muynak(unfavorable region)and Nukus(favorable region)of Uzbekistan.We measured 20 anthropometric parameters and assessed somatotype by the Heath-Carter method,peak height velocity(PHV),and maturity offset based on Mirwald's equation.In addition,the endocrine profile of 8 hormonal parameters was assessed,which includes growth factors,gonadotropins,sex steroids,and thyroid status.Results:We observed a positive dependence of physique,rate of maturation,and level of androgens,stimulated by gonadotropin hormones.Children living in unfavorable environmental regions show a decrease in folliclestimulating hormone,luteinizing hormone,total testosterone(the best predictor),and anthropometric signs of androgen deficiency.These resulted in an increase in maturity offset and PHV,combined with lower skeletal density and ectomorphic somatotype compared to their peers living in favorable environmental regions.Conclusion:Regional differences in stature,body weight,and anthropometric parameters of adipose tissue,growth factor axis,and thyroid hormones are the influencing indices in the regulation of growth in prepubertal children.We hypothesize that the inhibition of the gonadotropin-testosterone axis may result from endocrine disruption due to higher levels of toxic metals and pesticide exposure. 展开更多
关键词 Aral ecological disaster Endocrine disruption Prepubertal boys Hormonal profile Maturation Somatotype
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Ethylene enhances peanut seed germination by modulating hormonal and metabolic pathways 认领 引用
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作者 Yuanyuan Cui Haosong Guo +7 位作者 Qichao Wang Qingjing Meng Tianyu Li Jiancheng Zhang Xiaoyuan Chi Chun Fu Fa Cui Xiaoqin Liu 《Seed Biology》 2025年第1期194-204,共11页
Ethylene influences various physiological processes especially seed germination in plants.Through this study of ethylene on peanut seed germination,we found that soaking seeds in a 0.2 mM ethylene solution for 12 h,fo... Ethylene influences various physiological processes especially seed germination in plants.Through this study of ethylene on peanut seed germination,we found that soaking seeds in a 0.2 mM ethylene solution for 12 h,followed by water soaking,optimally promotes germination.To understand the mechanisms involved,we measured abscisic acid(ABA),gibberellins(GA),crude fat,and 18 fatty acids using GC-MS and also analyzed gene expression related to hormone pathways,fatty acid degradation,and cell wall loosening in both control and ethylene-treated seeds.Our results showed that ethylene significantly increased GA3 and GA4 expression levels,induced endogenous ethylene synthesis and signal transduction,and interfered with ABA signaling.Ethylene also enhanced fatty acid degradation and facilitated cell wall loosening.Notably,genes involved in these processes,such as the ethylene synthesis rate-limiting gene ACO,the ethylene receptor ETR,and cell wall loosening genes EXP and PEC,were significantly upregulated by ethylene treatment.In contrast,the abscisic acid-insensitive ABI5 was significantly downregulated after ethylene treatment.Further experiments confirmed that ethylene promoted the expression of three ERFs,which could bind to the promoter of ABI5 and inhibit its expression.This study is also the first to identify ethylene's role in promoting fatty acid degradation in peanut seeds.In conclusion,our findings reveal that ethylene enhances peanut seed germination through hormonal modulation,signal transduction enhancement,and metabolic adjustments.These insights provide a deeper understanding of ethylene's role in seed germination and offer potential applications for improving germination practices in agriculture. 展开更多
关键词 analyzed gene expression peanut seed germination hormonal modulation cell wall loosening seed germination physiological processes metabolic adjustments ethylene
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Influence of body mass index on semen quality: Examining sperm DNA fragmentation, protamine deficiency, and hormonal profiles 认领 引用
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作者 Mohammed M.Laqqan Maged M.Yassin 《Asian pacific Journal of Reproduction》 CAS 2025年第4期171-178,共8页
Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the a... Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the alterations related to reproductive hormones,semen parameters and their association with body mass index(BMI).Methods:Participants in this observational study were divided into three groups based on their BMI:proven fertile,normal weight men(n=200);overweight men(n=200);and obese men(n=200).After 3 days of abstinence,seminal fluid was collected from all participants and analyzed.Blood samples were also collected on the same day for hormonal analysis.Sperm DNA fragmentation and protamine deficiency were also assessed.Results:A total of 600 men with a mean age of(34.3±7.9)2 years were included in the study.Obese males(BMI 30 kg/m or higher)exhibited significant reductions in semen volume,sperm concentration,total sperm motility percentage,progressive motility,non-progressive motility,and levels of total testosterone,follicle-stimulating hormone(FSH)and luteinizing hormone(LH)compared to overweight(BMI 25 to 29.9 kg/m2)and normal weight males(BMI 18.5 to 24.9 kg/m2)(P<0.001).Conversely,obese males showed a significant increase in prolactin level,sperm DNA fragmentation,and protamine deficiency compared to overweight and normal weight males(P<0.001).Significant negative correlations were demonstrated between BMI and sperm concentration,motility,total testosterone,FSH and LH(P<0.001),whereas prolactin,sperm DNA fragmentation and protamine deficiency were positively correlated with BMI(P<0.001).Conclusions:This study provides clear evidence that obesity contributes potentially to male infertility by inducing sperm DNA fragmentation and protamine deficiency,as well as negatively impacting reproductive hormones and semen quality. 展开更多
关键词 Body mass index DNA fragmentation Protamine deficiency Reproductive hormonal Sperm
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Assessing Changes in Root Architecture,Developmental Timing,Transcriptional and Hormonal Profiles in Rice Co-Cultivated with Azolla filiculoides 认领 引用
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作者 Sara CANNAVÒ Chiara PALENI +9 位作者 Alma COSTARELLI Maria Cristina VALERI Martina CERRI Antonietta SACCOMANNO Veronica GREGIS Graziella Chini ZITTELLI Petre I.DOBREV Lara REALE Martin M.KATER Francesco PAOLOCCI 《Rice science》 SCIE CSCD 2025年第3期426-444,I0066-I0084,共19页
Strategies for increasing rice yield are needed to keep pace with the expected global population growth and sustainably address the challenges posed by climate change.In Southeast Asian countries,rice farming benefits... Strategies for increasing rice yield are needed to keep pace with the expected global population growth and sustainably address the challenges posed by climate change.In Southeast Asian countries,rice farming benefits from the use of Azolla spp.for nitrogen supply.By virtue of their symbiosis with the nitrogen-fixing cyanobacterium Trichormus azollae,Azolla spp.are ferns that release nitrogen into the environment upon biomass decomposition.However,whether and to what extent actively growing Azolla plants influence the development of co-cultivated rice seedlings remains unclear.To address this,rice(Oryza sativa L.var.Kitaake)seedlings were co-cultivated hydroponically with Azolla filiculoides for up to two months.Morphological changes in rice roots and aerial organs were assessed alongside nitric oxide assays in rice roots,root transcriptomics,and targeted hormonomics of rice roots,leaves,and growth media.Here,we showed that co-cultivation with actively growing A.filiculoides alters rice root architecture by inducing a nitric oxide boost and accelerates leaf and tiller differentiation and proliferation.Overall,this study provides an in-depth analysis of the morphogenetic effects of co-cultivated A.filiculoides on rice during early vegetative growth.It also paves the way for studies assessing whether A.filiculoides co-cultivation primes rice plants to better withstand abiotic and biotic stresses. 展开更多
关键词 Azolla hormone liquid chromatography-mass spectrometry Oryza sativa nitric oxide plant architecture root apparatus transcriptome Trichormus(Anabaena)azollae
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Hormonal interactions underlying parthenocarpic fruit formation in horticultural crops 认领 引用 被引量：12
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作者 Rahat Sharif Li Su +1 位作者 Xuehao Chen Xiaohua Qi 《Horticulture Research》 SCIE CSCD 2022年第1期132-148,共17页
In some horticultural crops,such as Cucurbitaceae,Solanaceae,and Rosaceae species,fruit set and development can occur without the fertilization of ovules,a process known as parthenocarpy.Parthenocarpy is an important ... In some horticultural crops,such as Cucurbitaceae,Solanaceae,and Rosaceae species,fruit set and development can occur without the fertilization of ovules,a process known as parthenocarpy.Parthenocarpy is an important agricultural trait that can not only mitigate fruit yield losses caused by environmental stresses but can also induce the development of seedless fruit,which is a desirable trait for consumers.In the present review,the induction of parthenocarpic fruit by the application of hormones such as auxins(2,4 dichlorophenoxyacetic acid;naphthaleneacetic acid),cytokinins(forchlorfenuron;6-benzylaminopurine),gibberellic acids,and brassinosteroids is first presented.Then,the molecular mechanisms of parthenocarpic fruit formation,mainly related to plant hormones,are presented.Auxins,gibberellic acids,and cytokinins are categorized as primary players in initiating fruit set.Other hormones,such as ethylene,brassinosteroids,and melatonin,also participate in parthenocarpic fruit formation.Additionally,synergistic and antagonistic crosstalk between these hormones is crucial for deciding the fate of fruit set.Finally,we highlight knowledge gaps and suggest future directions of research on parthenocarpic fruit formation in horticultural crops. 展开更多
关键词 hormonal interactions agricultural trait gibberellic acids induction parthenocarpic fruit mitigate fruit yield application hormones parthenocarpy auxins
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Genetic, hormonal, and environmental control of tillering in wheat 认领 引用 被引量：14
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作者 Qiushuang Shang Yaping Wang +3 位作者 Heng Tang Na Sui Xiansheng Zhang Fang Wang 《The Crop Journal》 SCIE CSCD 2021年第5期986-991,共6页
Tillering contributes greatly to grain yield in wheat.Investigating the mechanisms of tillering provides a theoretical foundation and genetic resources for the molecular breeding of wheat.The regulation of tillering i... Tillering contributes greatly to grain yield in wheat.Investigating the mechanisms of tillering provides a theoretical foundation and genetic resources for the molecular breeding of wheat.The regulation of tillering is a complex molecular process that involves a multitude of factors.Little is known about the molecular mechanisms in the wheat genome,although progress has been made in rice.Here we review the developmental characteristics of tillers and summarize current knowledge of the roles of endogenous and environmental factors in wheat tillering.We propose directions for future studies and advanced technologies to be used for gene identification and functional studies. 展开更多
关键词 Wheat Tillering Genetic control Hormonal regulation Environmental factor
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The feasibility and safety of high-intensity focused ultrasound combined with low-dose external beam radiotherapy as supplemental therapy for advanced prostate cancer following hormonal therapy 认领 引用 被引量：3
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作者 Rui-Yi Wu Guo-Min Wang +4 位作者 Lei Xu Bo-Heng Zhang Ye-Qing Xu Zhao-Chong Zeng Bing Chen 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第3期499-504,515,共6页
The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound （HIFU） combined with （＋） low-dose external beam radiotherapy （LRT） as supplemental therapy for advanced p... The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound （HIFU） combined with （＋） low-dose external beam radiotherapy （LRT） as supplemental therapy for advanced prostate cancer （PCa） following hormonal therapy （HT）. Our definition of HIFU＋LRT refers to treating primary tumour lesions with HIFU in place of reduced field boost irradiation to the prostate, while retaining four-field box irradiation to the pelvis in conventional-dose external beam radiotherapy （CRT）. We performed a prospective, controlled and non-randomized study on 120 patients with advanced PCa after HT who received HIFU, CRT, HIFU＋LRT and HT alone, respectively. CT/MR imaging showed the primary tumours and pelvic lymph node metastases visibly shrank or even disappeared after HIFU ＋LRT treatment. There were significant differences among four groups with regard to overall survival （OS） and disease-specific survival （DSS） curves （P=0.018 and 0.015）. Further comparison between each pair of groups suggested that the long-term DSS of the H IFU ＋ LRT group was higher than those of the other three groups, but there was no significant difference between the HIFU＋LRT group and the CRT group. Multivariable Cox＇s proportional hazard model showed that both HIFU＋LRT and CRT were independently associated with DSS （P=0.001 and 0.035） and had protective effects with regard to the risk of death. Compared with CRT, HIFU ＋LRT significantly decreased incidences of radiation-related late gastrointestinal （GI） and genitourinary （GU） toxicity grade ≥ II. In conclusion, long-term survival of patients with advanced PCa benefited from strengthening local control of primary tumour and reRional lymph node metastases after HT. As an alternative to CRT, HIFU＋LRT showed Rood efficacy and better safety. 展开更多
关键词 complication high-intensity focused ultrasound hormonal therapy low-dose external beam radiotherapy prostate cancer survival rate
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The safety of radium-223 combined with new-generation hormonal agents in bone metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis 认领 引用 被引量：2
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作者 Ming-Hao Wang Jin-Dong Dai +7 位作者 Xing-Ming Zhang Jin-Ge Zhao Guang-Xi Sun Yu-Hao Zeng Hong Zeng Nan-Wei Xu Hao Zeng Peng-Fei Shen 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第4期441-447,共7页
Patients with bone metastatic castration-resistant prostate cancer (mCRPC) might benefit from radium-223 (223Ra) combined withnew-generation hormonal agents (NHAs) in terms of survival and quality of life (QoL). Ho... Patients with bone metastatic castration-resistant prostate cancer (mCRPC) might benefit from radium-223 (223Ra) combined withnew-generation hormonal agents (NHAs) in terms of survival and quality of life (QoL). However, the safety of combination therapiesremains unclear. Therefore, we aimed to perform a network meta-analysis by reviewing the literature about the combination of223Ra with abiraterone acetate plus prednisone (AAP) or enzalutamide and to evaluate the safety of combination therapy in bonemCRPC patients. Ultimately, ten studies (2835 patients) were selected, including four randomized controlled trials (RCTs), fiveretrospective cohort studies, and one single-arm study. Overall, there was no difference in the incidence of fracture between the223Ra+NHA combination group and the 223Ra monotherapy group (odds ratio [OR]: 1.46, 95% confidence interval [CI]: 0.91–2.34,P = 0.66), but the incidences in both the 223Ra+NHA combination group (OR: 3.22, 95% CI: 2.24–4.63, P < 0.01) and the 223Ramonotherapy group (OR: 2.24, 95% CI: 1.23–4.08, P < 0.01) were higher than that in the NHA monotherapy group. However, inthe meta-analysis involving only RCTs, there was no difference between the 223Ra monotherapy group and the NHA monotherapygroup (OR: 1.14, 95% CI: 0.22–5.95, P = 0.88), while the difference between the 223Ra+NHA combination group and the NHAmonotherapy group remained significant (OR: 3.22, 95% CI: 2.24–4.63, P < 0.01). Symptomatic skeletal events (SSEs), SSE-freesurvival (SSE-FS), all grades of common adverse events (AEs), and ≥grade 3 AEs among all groups did not show any significantdifference. Our results indicate that the combination of 223Ra with NHAs was well tolerated in bone mCRPC patients compared to 223Ra monotherapy, even though the incidence of fracture was higher in patients who received 223Ra than that among those whoreceived NHA monotherapy. More evidence is needed to explore the safety and efficiency of 223Ra combination therapies. 展开更多
关键词 meta-analysis metastatic castration-resistant prostate cancer new-generation hormonal agents radium-223 safety
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Hormonal therapy might be a better choice as maintenance treatment than capecitabine after response to first-line capecitabine-based combination chemotherapy for patients with hormone receptor-positive and HER2-negative,metastatic breast cancer 认领 引用 被引量：10
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作者 Xue-Lian Chen Feng Du +5 位作者 Ruo-Xi Hong Jia-Yu Wang Yang Luo Qing Li Ying Fan Bing-He Xu 《Chinese Journal of Cancer》 2016年第6期46-52,共7页
Background:Both hormonal therapy(HT) and maintenance capecitabine monotherapy(MCT) have been shown to extend time to progression(TTP) in patients with metastatic breast cancer(MBC) after failure of taxanes and anthrac... Background:Both hormonal therapy(HT) and maintenance capecitabine monotherapy(MCT) have been shown to extend time to progression(TTP) in patients with metastatic breast cancer(MBC) after failure of taxanes and anthracycline?containing regimens.However,no clinical trials have directly compared the efficacy of MCT and HT after response to first?line capecitabine?based combination chemotherapy(FCCT) in patients with hormone receptor(HR)?positive and human epidermal growth factor receptor 2(HER2)?negative breast cancer.Methods:We retrospectively analyzed the charts of 138 HR?positive and HER2?negative MBC patients who were in non?progression status after FCCT and who were treated between 2003 and 2012 at the Cancer Institute and Hospital,Chinese Academy of Medical Sciences,in Beijing,China.The median number of first?line chemotherapy cycles was 6(range,4–8);combined agents included taxanes,vinorelbine,or gemcitabine.Of these 138 patients,79 received MCT,and 59 received HT.Single?agent capecitabine was administered at a dose of 1250 mg/m2 twice daily for 14 days,followed by a 7?day rest period,repeated every 3 weeks.Of the 59 patients who received HT,37 received aromatase inhibitors(AIs),8 received selective estrogen receptor modulators(SERMs),and 14 received goserelin plus either AIs or SERMs.We then compared the MCT group and HT group in terms of treatment efficacy.Results:With a median follow?up of 43 months,patients in the HT group had a much longer TTP than patients in the MCT group(13 vs.8 months,P ease?free surviv= 0.011).When TTP was adjusted for age,menopausal status,Karnofsky performance status score,disal,site of metastasis,number of metastatic sites,and response status after FCCT,extended TTP was still observed for patients in the HT group(hazard ratio:0.63;95% confidence interval:0.44–0.93;P = 0.020).We also observed a trend of overall survival advantage for patients in the HT group vs.patients in the MCT group,but the difference was not significant(43 vs.37 months,P tients in the MCT g= 0.400).In addition,patients in the HT group gen?erally tolerated the treatment well,whereas paroup experienced grades 3–4 adverse events,the most frequent of which were hand?foot syndrome(15.8%) and hematologic abnormalities(7.6%).Conclusion:For HR?positive and HER2?negative MBC patients,HT might be considered a treatment after response to FCCT but prior to MCT as a long?term administration. 展开更多
关键词 Hormonal therapy Maintenance capecitabine monotherapy First-line capecitabine-based combination chemotherapy Metastatic breast cancer
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Luteinizing hormone-releasing hormone receptor agonists and antagonists in prostate cancer:effects on long-term survival and combined therapy with next-generation hormonal agents 认领 引用
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作者 Jinge Zhao Junru Chen +2 位作者 Guangxi Sun Pengfei Shen Hao Zeng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第11期1012-1032,共21页
Prostate cancer is a leading cause of cancer-related death in men worldwide.Luteinizing hormone-releasing hormone receptor(LHRH-R)agonists and antagonists are known to achieve castration-level testosterone suppression... Prostate cancer is a leading cause of cancer-related death in men worldwide.Luteinizing hormone-releasing hormone receptor(LHRH-R)agonists and antagonists are known to achieve castration-level testosterone suppression;however,long-term data comparing the survival benefits of these therapies are insufficient to inform treatment decisions.Furthermore,the advent of nextgeneration hormonal agents(NHAs),such as abiraterone and enzalutamide,have shifted the paradigm of managing prostate cancer.Although LHRH-R agonists and antagonists remain the cornerstone treatment across various stages of prostate cancer,they are increasingly administered with NHAs,because the combination treatment confers a survival advantage.Nevertheless,the differences in efficacy and safety profiles among various combinations of LHRH-R agonists and antagonists and NHAs remain unclear.Hence,this narrative review is aimed at providing a comprehensive overview of the long-term outcomes of various LHRH-R agonists and antagonists.Key data from major clinical studies are summarized,categorized by disease stage.LHRH-R agonists and antagonists,particularly goserelin,have demonstrated long-term survival benefits in patients with localized and locally advanced prostate cancer.The clinical outcomes of different LHRH-R agonists and antagonists in combination with NHAs have also been evaluated.Among the various combinations,goserelin plus abiraterone appears to have a manageable safety profile with relatively low rates of hot flushes and fatigue.Overall,long-term survival data and safety profiles should be considered in selecting optimal combination therapies for prostate cancer treatment. 展开更多
关键词 Luteinizing hormone-releasing hormone receptor agonists luteinizing hormone-releasing hormone receptor antagonists prostate cancer long-term survival next-generation hormonal agents
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Effectiveness and adverse effects of hormonal therapy for prostate cancer: Japanese experience and perspective 认领 引用
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作者 Mikio Namiki Satoru Ueno +2 位作者 Yasuhide Kitagawa Takashi Fukagai Hideyuki Akaza 《Asian Journal of Andrology》 SCIE CAS CSCD 2012年第3期451-457,I0007,I0008,共7页
Recently, novel anti-androgens and inhibitors of androgen biosynthesis have been developed through the elucidation of mechanisms of castration resistance of prostate cancer. We believe that these new developments will... Recently, novel anti-androgens and inhibitors of androgen biosynthesis have been developed through the elucidation of mechanisms of castration resistance of prostate cancer. We believe that these new developments will improve hormonal therapy. On the other hand, there has been an increase in criticism of hormonal therapy, because hormonal therapy is supposed to induce adverse effects such as cardiovascular disease. In this review, we have introduced the Japanese experience of hormonal therapy, because we believe that there may be ethnic differences between Caucasians and Asian people in the efficacy and adverse effects of hormonal therapy. First, we showed that primary hormonal therapy can achieve long-term control of localized prostate cancer in some cases and that quality of life of patients receiving hormonal therapy is rather better than previously thought. Neoadjuvant and adjuvant hormonal therapy in cases undergoing radical prostatectomy or radiotherapy are very useful for high-risk or locally advanced prostate cancer. Further clinical trials are required to confirm the efficacy of neoadjuvant or adjuvant hormonal therapy. We showed that the death from cardiovascular dis- eases in Japanese patients receiving hormonal therapy was not higher than that in the general population. However; efforts should be made to decrease the adverse effects of hormonal therapy, because life-style change may increase the susceptibility to adverse effects by hormonal therapy even in Japan. Managements of endocrine and metabolic dysfunction, such as diabetes mellitus, are essential. New hormonal compounds such as selective androgen receptor modulators capable of specifically targeting prostate cancer are expected to be developed. 展开更多
关键词 adverse effects androgen deprivation therapy hormonal therapy prostate cancer
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Hormonal contraception in Chinese men: variations insuppression of spermatogenesis with injectable testosteroneundecanoate and levonorgestrel implants 认领 引用 被引量：3
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作者 Si-TianLiu You-LunOui +1 位作者 Cui-HongLin Chang-HalHe 《Asian Journal of Andrology》 SCIE CAS 2004年第1期41-46,共6页
Aim: To explore the causes of the difference in spermatogenic suppression between responders and non-responders in Chinese men treated with levonorgestrel (LNG) implants plus testosterone undecanoate (TU) injectable. ... Aim: To explore the causes of the difference in spermatogenic suppression between responders and non-responders in Chinese men treated with levonorgestrel (LNG) implants plus testosterone undecanoate (TU) injectable. Methods: The 16 Chinese volunteers treated were divided into two groups in regard to the sperm count during the treatment period, 7 men in the responder group (Group R), including 6 azoospermia and one severe oligozoospermia, and the remaining 9 in the non-responder group (Group N), including 4 oligozoospermia and 5 with sperm counts greater than 20×106/mL. The differences in serum profiles of FSH, LH, T, LNG and T/LH ratio were compared between the two groups and the correlation between the seminal fluid parameters and serum reproductive hormones was analyzed. Results: The serum FSH level was lower in Group R than that in Group N (P<0.05), while the serum LH and LNG levels were higher in Group R than those in Group N (P<0.05). The sperm density (P<0.01, r=0.235), motility (P<0.01, r=0.326) and vitality (P<0.01, r=0.219) showed significantly positive correlation with the serum FSH level. Conclusion: The blood LNG and T levels, the degree of FSH inhibition and/or the sensitivity of the pituitary-testis axis to exogenous steroids, as well as the individual spermatogenetic potential and the functional status of the Leydig cells may be factors bringing about individual differences in spermatogenic suppression in Chinese men treated with LNG and TU. 展开更多
关键词 levonorgestrel testosterone undecanocate spermatogenesis hormonal contraception
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Bone flare after initiation of novel hormonal therapy in patients with metastatic hormone-sensitive prostate cancer:A case report 认领 引用 被引量：1
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作者 Ke-Hao Li Yuan-Cheng Du +4 位作者 Dong-Yu Yang Xin-Yuan Yu Xue-Ping Zhang Yong-Xiang Li Liang Qiao 《World Journal of Clinical Cases》 SCIE 2022年第15期4985-4990,共6页
BACKGROUND The 2020 European Association of Urology prostate cancer guidelines recommend androgen deprivation therapy(ADT)in combination with apalutamide and enzalutamide,a new generation of androgen receptor antagoni... BACKGROUND The 2020 European Association of Urology prostate cancer guidelines recommend androgen deprivation therapy(ADT)in combination with apalutamide and enzalutamide,a new generation of androgen receptor antagonists,as first-line therapy.A decrease in prostate-specific antigen(PSA)levels may occur in the early stages of novel hormonal therapy;however,radionuclide bone imaging may suggest disease progression.During follow-up,PSA,radionuclide bone imaging,and prostate-specific membrane antigen(PSMA)positron emission tomography–computed tomography(PET-CT)are needed for systematic evaluation.CASE SUMMARY We admitted a 56-year-old male patient with metastatic hormone-sensitive prostate cancer.Initial radionuclide bone imaging,magnetic resonance imaging(MRI),and PSMA PET-CT showed prostate cancer with multiple bone metastases.Ultrasound-guided needle biopsy of the prostate revealed a poorly differentiated adenocarcinoma of the prostate with a Gleason score:5+4=9.The final diagnosis was a prostate adenocarcinoma(T4N1M1).ADT with novel hormonal therapy(goseraline sustained-release implant 3.6 mg monthly and apalutamide 240 mg daily)was commenced.Three months later,radionuclide bone imaging and MRI revealed advanced bone metastasis.However,PSMA PET-CT examination showed a significant reduction in PSMA aggregation on the bone,indicating improved bone metastases.Considering that progressive decrease in the presenting lumbar pain,treatment strategies were considered to be effective.CONCLUSION ADT using novel hormonal therapy is effective for treating patients with prostate adenocarcinoma.Careful evaluation must precede treatment plan changes. 展开更多
关键词 Bone flare Novel hormonal therapy Metastatic hormone-sensitive prostate cancer Apalutamide Case report
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Retinal vein occlusion associated with combined hormonal contraceptive vaginal ring use 认领 引用 被引量：2
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作者 Albert S.Li Jonathan Naysan Ronni M.Lieberman 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第5期891-892,共2页
Dear Editor,We read with interest your recent article on the impact of combined oral contraceptives on ocular tissues.We report a case of a branch retinal vein occlusion（BRVO）associated with use of an etonogestrel/e... Dear Editor,We read with interest your recent article on the impact of combined oral contraceptives on ocular tissues.We report a case of a branch retinal vein occlusion（BRVO）associated with use of an etonogestrel/ethinyl estradiol vaginal ring（NuvaR ing）,an implantable combined hormonal contraceptive,in a young healthy female with no other identifiable risk factors. 展开更多
关键词 Retinal vein occlusion hormonal contraceptive vaginal ring use
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The effects of aqueous extracts of Tetracarpidium conophorum seeds on the hormonal parameters of male guinea pigs 认领 引用 被引量：1
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作者 Obianime AW Uche FI 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第1期21-24,共4页
Objective:To investigate the effects of the aqueous extracts of the seeds of Tetracarpidium conophorum and the effect of Proviron(12.5 mg/kg)(as standard) on the hormonal parameters of male guinea pigs,compare the eff... Objective:To investigate the effects of the aqueous extracts of the seeds of Tetracarpidium conophorum and the effect of Proviron(12.5 mg/kg)(as standard) on the hormonal parameters of male guinea pigs,compare the effects of the seeds of Tetracarpidium conophorum and Proviron,and screen the phytochemical constituents of the seeds of Tetracarpidium conophorum.Methods:The hormonal effects of the Tetracarpidium conophorum and Proviron were tested by hormonal assay,using enzyme immuno assay method.This was done by reaction of antibody with serum testosterone and testosterone label,magnetic solid phase separation and colour development step.Phytochemical screening was done using standard procedures. Results:The aqueous extract of the Tetracarpidium conophorum seeds(100-400 mg/kg) caused a statistically significant increase(P【0.05,ANOVA) in the level of testosterone of male guinea pigs,from(2.60±0.06) ng/mL to(3.40±0.05) ng/mL,(3.00±0.60) ng/mL and(3.30±0.45) ng/mL on the 7th,14th and 21st day of the administration of the extracts,respectively.The highest increase was obtained after the 7th day of treatment[(3.40±0.05) ng/mL].These effects were very comparable to the effects of Proviron on the testosterone of male guinea pigs,which were obtained to be(2.80±0.01) ng/mL,(2.90±0.16) ng/mL and(3.10±0.30) ng/mL on the 7th, 14th and 21st day,respectively.These effects were dose-and time-dependent.The optimum effect on testosterone level under dose-dependent study f(4.70±0.45) ng/mL]was obtained at 300 mg/kg of Tetracarpidium conophorum after 7 days treatment.Finally,the phytochemical screening of the seeds of Tetracarpidium conophorum revealed the presence of flavonoids, tannin,alkaloids,carbohydrate,volatile oils,terpenoids,saponins and cardiac glycosides. Conclusion:This study supports the claims on the use of the seeds of this plant by traditional medicine practitioners as a fertility agent.However,further studies need to be done to isolate and characterize the active principle(s) responsible for this activity in this plant. 展开更多
关键词 Tetracarpidium conophorum Hormonal parameters Male guinea pigs
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Progress in understanding hormonal regulation during the postembryonic development of Helicoverpa armigera 认领 引用 被引量：2
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作者 ZHAO Xiao-fan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2020年第6期1417-1428,共12页
Lepidoptera,with 0.16 million species,is the second largest order of insecta.This order includes silk worms,butterflies,and many agricultural pests.The cotton bollworm,Helicoverpa armigera(Hubner)is one of the pests i... Lepidoptera,with 0.16 million species,is the second largest order of insecta.This order includes silk worms,butterflies,and many agricultural pests.The cotton bollworm,Helicoverpa armigera(Hubner)is one of the pests in Lepidoptera that seriously harms cotton plant and other crops in China and other countries.This pest develops resistance to chemical insecticides rapidly.Bacillus thuringiensis(Bt)transgenic cotton plants are developed to control H.armigera population in the field.However,duri ng the past years,the rapid evoluti on of Bt toxi n resista nee is observed in H.armigera in tran sge nic cott on fields.New approaches for the development of new envir on mentally friendly insecticides to control H.armigera have become necessary,and the molecular mechanisms underlying the development and physiological processes of this species need to be further understood.Considerable progress in the study of H.armigera development and physiology has been achieved in the last decade.This mini-review summarizes the main fin dings on the molecular mechanisms of horm onal regulation of the development of H.armigera to present new target genes for developing new approaches to control the pest. 展开更多
关键词 Helicoverpa armigera Lepidoptera hormonal regulation development pest control
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