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Combined assessment with stress hyperglycemia ratio and time in range:Associations with twenty-eight-day mortality in surgical intensive care unit patients 认领 引用
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作者 Shuang Liu Bai-Ge Cao +3 位作者 Yue Ma Jin-Fang Xu Quan-Hong Zhou Cong-Rong Wang 《World Journal of Diabetes》 SCIE 2026年第1期89-96,共8页
BACKGROUND The stress hyperglycemia ratio(SHR)reflects patients’acute hyperglycemia status,and the time in range(TIR)captures glucose control dynamics during their intensive care unit(ICU)stays.AIM To investigate the... BACKGROUND The stress hyperglycemia ratio(SHR)reflects patients’acute hyperglycemia status,and the time in range(TIR)captures glucose control dynamics during their intensive care unit(ICU)stays.AIM To investigate the independent and combined associations of SHR and TIR with 28-day mortality among surgical ICU patients.METHODS In total,706 adult patients with available glucose data were included.SHR was calculated as the ratio of admission glucose levels to glycosylated hemoglobinderived estimated average glucose.TIR was calculated as percentages of glucose readings within the 3.9-10.0 mmol/L range during the ICU stay.SHR and TIR were divided into quartiles,and patients were allocated to four groups according to combinations of high/low values.The associations of the SHR,TIR,and both combined with mortality were assessed using logistic regression.RESULTS Logistic regression analysis demonstrated that patients in the highest SHR quartile had a significantly increased risk of 28-day mortality compared with the reference quartile[adjusted odds ratio(OR)=2.24;95%confidence interval(CI):1.06-4.71;P=0.033].In contrast,higher TIR were associated with a reduced risk of 28-day mortality.Compared with the lowest TIR quartile(Q1),adjusted ORs in Q2,Q3,and Q4 were 0.43(95%CI:0.23-0.93;P=0.030),0.43(95%CI:0.19-0.99;P=0.046),and 0.41(95%CI:0.17-0.98;P=0.045),respectively.When the SHR and TIR were analyzed in combination,patients with high SHR and low TIR had the highest risk of 28-day mortality(adjusted OR=2.19;95%CI:1.05-4.58;P=0.038).CONCLUSION Combined SHR and TIR assessment offers prognostic value in surgical ICU patients.Maintaining glucose within the target range may be important to improve short-term outcomes in patients with stress hyperglycemia. 展开更多
关键词 Surgical intensive care unit Stress hyperglycemia ratio Time in range Twenty-eight-day mortality Hyperglycemia
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Hypoxia-inducible factor-1:A new neuroprotective agent for the treatment of hyperglycemia after stroke 认领 引用
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作者 María Isabel Hernández Jose L.Zugaza Abraham Martín 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4061-4067,共7页
Acute hyperglycemia in ischemic stroke occurs in almost half of cases,inducing a worsening of the underlying pathophysiology.Hence,the management of acute hyperglycemia during the first hours following ischemic stroke... Acute hyperglycemia in ischemic stroke occurs in almost half of cases,inducing a worsening of the underlying pathophysiology.Hence,the management of acute hyperglycemia during the first hours following ischemic stroke requires well-defined strategies.Furthermore,the effect of hyperglycemia on stroke remains an unresolved paradoxical process whose possible causes are still unknown.The ischemic process involves the activation of multiple signaling pathways related to cell death and survival,which can be acutely altered by hyperglycemia,causing subsequent worsening of the ischemic process.In search of potential biological targets to combat this medical burden,the role of hypoxia-inducible factor appears as a novel neuroprotective agent that needs further investigation.Furthermore,hypoxia-inducible factor protein targets multiple pathways changing depending on factors such as the severity of hypoxia,the time elapsed after reperfusion and the specific cell type.In fact,the poor prognosis of ischemic stroke associated with acute hyperglycemia has been linked to alterations in hypoxia-inducible factor-1αprotein function.Together,these findings support this transcription factor as a new therapeutic target to prevent the negative effect of hyperglycemia,opening new avenues for treatment in stroke. 展开更多
关键词 acute hyperglycemia hypoxia-inducible factor-1α ischemic stroke neuroprotective agents post-translational modifications
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Stress hyperglycemia and early mortality in non-ST elevation myocardial infarction 认领 引用
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作者 Emir Becirovic Minela Becirovic +5 位作者 Jusuf Hodzic Amir Becirovic Mugdim Bajric Admir Abdic Fahrudin Sabanovic Emir Begagic 《World Journal of Cardiology》 2026年第5期79-89,共11页
BACKGROUND Acute hyperglycemia is frequently observed in patients presenting with acute coronary syndromes and is considered a marker of metabolic and neurohormonal stress.However,its prognostic significance relative ... BACKGROUND Acute hyperglycemia is frequently observed in patients presenting with acute coronary syndromes and is considered a marker of metabolic and neurohormonal stress.However,its prognostic significance relative to chronic glycemic status remains incompletely understood,particularly in patients with non-ST-segment elevation myocardial infarction(NSTEMI).Glycated hemoglobin(HbA1c)reflects long-term glycemic control but may not adequately capture acute metabolic derangements occurring during myocardial ischemia.Stress hyperglycemia reflects a transient metabolic response to acute illness mediated by counter-regulatory hormones,systemic inflammation,and increased hepatic gluconeogenesis,and does not necessarily indicate pre-existing insulin resistance or chronic dysglycemia.Recent studies suggest that stress-related hyperglycemia indices may better reflect short-term risk,yet comparative data in NSTEMI populations remain limited.AIM To determine whether admission stress hyperglycemia indices are associated with early mortality in patients with non-ST elevation myocardial infarction.METHODS This prospective,single-center observational study consecutively enrolled 171 patients admitted with confirmed NSTEMI.Stress hyperglycemia was assessed using the stress hyperglycemia ratio(SHR)and the admission glucose-to-chronic glycemia ratio(ACGR),calculated from admission plasma glucose and HbA1c values obtained at hospital presentation.Patients were categorized according to established HbA1c thresholds.Clinical,laboratory,and echocardiographic data were systematically collected.All patients were followed for three months after discharge.The primary endpoint was the occurrence of major adverse cardiovascular events(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction,or urgent coronary revascularization.The secondary endpoint was all-cause mortality.Discriminatory performance was evaluated using receiver operating characteristic(ROC)curve analysis.Multivariable logistic regression models were constructed to assess the independent and incremental prognostic value of stress hyperglycemia indices before and after adjustment for established clinical and echocardiographic predictors.RESULTS During the three-month follow-up period,88 MACE and 25 deaths were recorded.HbA1c categories were not significantly associated with all-cause mortality or MACE.In contrast,admission glucose levels,SHR,and ACGR were significantly higher in non-survivors than in survivors.No significant differences in HbA1c were observed between outcome groups.Stress hyperglycemia indices demonstrated modest discriminatory ability for predicting mortality and showed greater discrimination than HbA1c in ROC analyses.In multivariable models,both SHR and ACGR remained independently associated with early mortality after adjustment for demographic,clinical,and echocardiographic variables,whereas no independent association with the composite MACE endpoint was observed.ROC-derived thresholds used for survival analyses were exploratory and have not been externally validated.CONCLUSION In patients with NSTEMI,stress hyperglycemia indices assessed at hospital admission are independently associated with early mortality,whereas chronic glycemic status shows limited prognostic relevance.These indices appear to reflect acute systemic stress and metabolic instability and may provide clinically useful information for early risk stratification during the initial phase of hospitalization,particularly when comprehensive echocardiographic assessment is not yet available. 展开更多
关键词 Non-ST elevation myocardial infarction Stress hyperglycemia Glycated hemoglobin Mortality Major adverse cardiovascular events
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Effects of hyperglycemia on the bone microenvironment in diabetic osteoporosis 认领 引用
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作者 Bo Li Wei Wei +1 位作者 Yan-Long Zhang Xi-Xu Zhang 《World Journal of Diabetes》 SCIE 2026年第7期83-96,共14页
With the global surge in diabetes mellitus prevalence,diabetic osteoporosis(DOP)has become a pressing public health challenge because it markedly increases fracture risk and impairs bone repair capacity.The bone micro... With the global surge in diabetes mellitus prevalence,diabetic osteoporosis(DOP)has become a pressing public health challenge because it markedly increases fracture risk and impairs bone repair capacity.The bone microenvironment,a dynamic ecosystem that maintains skeletal integrity,undergoes profound pathological changes under chronic hyperglycemia:Excessive reactive oxygen species production induced by high glucose and accumulation of advanced glycation end products together trigger oxidative stress and chronic low-grade inflammation in the bone microenvironment(e.g.,activation of the nuclear factorkappa B signaling pathway).These processes,by inhibiting osteoblast differentiation,enhancing osteoclast activity,and damaging microvascular supply,disrupt the coupled balance of bone remodeling.This article aims to systematically review the effects of hyperglycemia on the bone microenvironment and its molecular mechanisms,clarify the pathological basis of DOP,and provide a theoretical foundation for identifying new targets for prevention,treatment,and clinical intervention. 展开更多
关键词 Diabetic osteoporosis Bone microenvironment Hyperglycemia Oxidative stress Inflammation
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Stress hyperglycemia ratio and long-term prognosis in patients with acute myocardial infarction undergoing percutaneous coronary intervention:evidence for an J-shaped association 认领 引用
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作者 Ning WANG Yi-Shuo XU +4 位作者 Xue FENG Ming ZENG Xi CHEN Bo YU Jun-Jie KOU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2025年第12期981-991,共11页
BACKGROUND Acute myocardial infarction(AMI)is a major cause of mortality worldwide.The stress hyperglycemia ratio(SHR),which integrates glucose and glycated hemoglobin A1c levels,better reflects acute metabolic stress... BACKGROUND Acute myocardial infarction(AMI)is a major cause of mortality worldwide.The stress hyperglycemia ratio(SHR),which integrates glucose and glycated hemoglobin A1c levels,better reflects acute metabolic stress.This study assessed the SHR and longterm prognosis of patients with AMI.METHODS This study was a post-hoc analysis based on the prospective,multicenter OPTIMAL registry(http://gffzz1caf53c915c04334h5k6pu6fqc9p06wvn.ffgz.tsg.suse.edu.cn,NCT number:NCT03084991).A total of 3384 consecutive patients who underwent percutaneous coronary intervention(PCI)at Department of Cardiology,The 2nd Affiliated Hospital of Harbin Medical University,Harbin,China were included in the present analysis after exclusions.Patients were stratified into quartiles according to the SHR.The primary endpoint was cardiovascular death,with all-cause death and major adverse cardiovascular events as secondary endpoints.The median follow-up duration was 24.1 months,with a completion rate of 99.5%.RESULTS Kaplan-Meier survival curves showed progressively worse survival across SHR quartiles(log-rank P<0.001),with patients in Q4(SHR≥1.34)experiencing the highest risk.Multivariate Cox regression analysis confirmed that the SHR was an independent predictor of cardiovascular death[hazard ratio(HR)=1.56],all-cause death(HR=1.48),and major adverse cardiovascular events(HR=1.34)for Q4(SHR≥1.34)versus Q2(SHR:0.93–1.11).Restricted cubic spline analysis revealed a J-shaped association between SHR and outcomes,with the lowest risk observed at an SHR of approximately 1.0.CONCLUSIONS The SHR is an independent predictor of long-term adverse outcomes in patients with AMI undergoing PCI,supporting its use for early risk stratification and glycemic management. 展开更多
关键词 acute myocardial infarction ami stress hyperglycemia ratio J shaped association stress hyperglycemia ratio shr which long term prognosis percutaneous coronary percutaneous coronary intervention acute myocardial infarction
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Edible prodelphinidins that improve postprandial hyperglycemia were discovered in Chinese bayberry(Myrica rubra Sieb.et Zucc.)fruits 认领 引用
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作者 Yi Wang Laiming Zhang +4 位作者 Jiaxiong Wu Chengxiao Yu Xingqian Ye Haibo Pan Shiguo Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第3期1008-1016,共9页
Plant polyphenols are potential substitutes for clinicalα-glucosidase inhibitors.Our previous studies indicated that prodelphinidins from Chinese bayberry leaves(BLPs)have strongerα-glucosidase inhibitory activity t... Plant polyphenols are potential substitutes for clinicalα-glucosidase inhibitors.Our previous studies indicated that prodelphinidins from Chinese bayberry leaves(BLPs)have strongerα-glucosidase inhibitory activity than other common polyphenols,but they have no safe history of consumption.There is a reasonable prospect that prodelphinidins from Chinese bayberry fruits(BFPs)can improve postprandial hyperglycemia,though known active components are only myricetin and cyanidin-3-O-glucoside.Hence,the aim of this study was to analyze structure and hypoglycemic effect of BFPs of“Biqi”(BQPs)and“Dongkui”(DKPs)cultivars,and compare their difference with BLPs.The contents of BQPs and DKPs were(221.73±0.60)and(136.82±4.33)mg epicatechin(EC)equivalents/g dry weight,respectively.The most subunits were epigallocatechin gallate along with a small amount of epigallocatechin,epicatechin gallate and EC connected by B-type linkages and a small portion of A-type linkages with mean polymerization degree of 4.25 and 4.08,respectively.Importantly,BQPs and DKPs wereα-glucosidase inhibitors with half inhibitory concentration of 11.91 and 9.47μg/m L respectively,which were significantly stronger than BLPs.DKPs could also improve postprandial hyperglycemia of normal mice and high fat diet-induced type II diabetic mice.Therefore,edible prodelphinidins,which have stronger hypoglycemic effect than BLPs,were first found in Chinese bayberry fruits. 展开更多
关键词 Chinese bayberry fruit Prodelphinidins Structure α-Glucosidase Postprandial hyperglycemia
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Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia 认领 引用
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作者 Sebastian Mas-Fontao Esther Civantos +7 位作者 Nisa Boukichou-Abdelkader Juan Antonio Moreno Carmen Gomez-Guerrero M Isabel López Gálvez Jaakko Tuomilehto Marcus Lind Rafael Gabriel Jesús Egido 《World Journal of Diabetes》 SCIE 2025年第9期139-154,共16页
BACKGROUND Diabetes and its associated microvascular complications,such as nephropathy and retinopathy,significantly impact global health.These complications often begin in the prediabetic stage,emphasizing the import... BACKGROUND Diabetes and its associated microvascular complications,such as nephropathy and retinopathy,significantly impact global health.These complications often begin in the prediabetic stage,emphasizing the importance of early detection and intervention.Inflammatory pathways are key contributors to these conditions,and recent research has identified members of the tumor necrosis factor(TNF)receptor superfamily as potential biomarkers.However,their association with renal and retinal dysfunction in individuals with intermediate hyperglycemia(IH)remains underexplored.The Early Prevention of Diabetes Complications(ePREDICE)trial provides a valuable cohort to investigate these associations and improve risk assessment strategies.AIM To identify inflammatory biomarkers associated with early renal and retinal dysfunction in individuals with IH.Specifically,we evaluate the diagnostic and prognostic potential of TNF receptor superfamily members[TNF receptor 1(TNF-R1),TNF receptor 2(TNF-R2)],T-cell immunoglobulin and mucin domain 3(TIM-3)/HAVCR2,galectin-3,and interleukin-6(IL-6)in detecting kidney dysfunction and retinopathy in this high-risk population.By understanding their roles,we seek to enhance early screening methods and inform personalized intervention strategies.METHODS A cross-sectional analysis of 967 individuals with IH from the ePREDICE trial was conducted.Participants underwent comprehensive anthropometric and biochemical assessments.Key inflammatory biomarkers,including TNF-R1,TNF-R2,TIM-3/HAVCR2,galectin-3,and IL-6,were quantified using immunoassays.Renal function was assessed using estimated glomerular filtration rate(eGFR)and albuminuria,while retinopathy was evaluated through fundoscopic examination.Statistical analyses included adjusted mean comparisons,correlation studies,and receiver operating characteristic curve analysis to assess biomarker diagnostic accuracy.RESULTS TNF-R1,TNF-R2,and TIM-3/HAVCR2 were significantly associated with reduced filtration function(eGFR0.75)were observed among TNF-R1,TNF-R2,and TIM-3/HAVCR2,suggesting a coordinated role in inflammatory pathways.CONCLUSION Our findings highlight the potential of TNF receptor superfamily members as biomarkers for early-stage renal and retinal complications in individuals with IH.Their integration into clinical screening protocols could facilitate earlier detection,improving patient stratification and personalized management strategies.Further longitudinal studies are necessary to validate their predictive value and potential for guiding therapeutic interventions in IH and early diabetes management. 展开更多
关键词 Biomarkers Microvascular complications Intermediate hyperglycemia Renal function Tumor necrosis factor receptor
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Impact of intensive insulin therapy on dynamic cardiac function in critically ill patients with stress-induced hyperglycemia 认领 引用
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作者 Yu-Dan Wang Jing-Jing Yu 《World Journal of Diabetes》 SCIE 2025年第7期244-252,共9页
BACKGROUND Stress-induced hyperglycemia(SIH)is common in critically ill patients and has been associated with adverse cardiovascular outcomes.Intensive insulin therapy(IIT)has been proposed to mitigate these risks by ... BACKGROUND Stress-induced hyperglycemia(SIH)is common in critically ill patients and has been associated with adverse cardiovascular outcomes.Intensive insulin therapy(IIT)has been proposed to mitigate these risks by achieving tighter glycemic control.AIM To evaluate the efficacy of IIT for managing SIH in critically ill patients and to explore its potential effect on cardiac function.METHODS A retrospective study was conducted at our hospital from January 2021 to December 2024,adhering to STROBE guidelines.A total of 186 critically ill pa-tients were divided into normal glycemia(n=85)and SIH(n=101)groups.The SIH cohort was further subdivided into conventional treatment(n=50)and IIT(n=51)groups.Hemodynamic parameters-including right atrial pressure(RAP),pulmonary artery pressure(PAP),pulmonary capillary wedge pressure(PAWP),cardiac output(CO),cardiac index(CI),and B-type natriuretic peptide(BNP)-were measured at baseline and post-treatment.Clinical outcomes such as intensive care unit(ICU)length of stay,mechanical ventilation requirements,and mortality were also recorded.Statistical analyses were conducted using inde-pendent samples t-tests and χ2/Fisher’s exact tests.RESULTS SIH markedly worsened haemodynamics versus normal glycaemia:RAP 9.8±5.1 vs 6.1±3.5 mmHg,PAP 35.2±16.0 vs 26.2±10.3 mmHg,PAWP 16.0±7.0 vs 8.6±6.4 mmHg,CO 3.3±2.3 vs 6.0±3.3 L/min,CI 1.88±0.24 vs 2.70±0.50 L/min/m2,BNP 465±250 vs 180±53 pg/mL(all P<0.001).Within the SIH cohort,IIT outperformed conventional therapy:RAP 7.0±2.2 vs 8.3±3.9 mmHg(P=0.04),PAP 21.6±3.7 vs 29.3±6.5 mmHg(P<0.001),PAWP 10.2±5.4 vs 13.8±5.3 mmHg(P=0.001),CO 4.9±2.2 vs 4.0±1.4 L/min(P=0.022),CI 2.58±0.32 vs 2.11±0.31 L/min/m2,P<0.001),BNP 202±62 vs 346±171 pg/mL(P<0.001).Clinically,IIT shortened ICU stay(10.3±3.4 vs 14.5±2.6 days,P<0.001),reduced ventilator use(56.9%vs 76.0%,P=0.042),and lowered mortality(23.5%vs 42.0%,P=0.048).CONCLUSION IIT significantly reduced cardiac filling pressures,improved cardiac function,and was associated with favorable clinical outcomes in SIH patients,suggesting potential benefits of stricter glycaemic control in critically ill patients.However,given the retrospective design and absence of glucose-variability monitoring,these findings should be interpreted with caution. 展开更多
关键词 Intensive insulin therapy Stress-induced hyperglycemia Cardiac function Critically ill patients Intensive care unit
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Overexpression of Circ-Astn1 Suppresses Hyperglycemia-Induced Endothelial Cell Damage via the miR-138-5p/SIRT1 Axis 认领 引用
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作者 Hong-bin Yu Li-yun Wang +4 位作者 Xiao-ning Yan Xue-yan Wu Jian-long Wu Da-wei Liu Si-yang Liu 《Current Medical Science》 SCIE CAS CSCD 2025年第1期93-103,共11页
Objective To elucidate the regulatory mechanism of circRNAs in diabetic retinopathy.Methods Next-generation sequencing(NGS)was employed to identify circRNAs that are abnormally expressed in endothe-lial progenitor cel... Objective To elucidate the regulatory mechanism of circRNAs in diabetic retinopathy.Methods Next-generation sequencing(NGS)was employed to identify circRNAs that are abnormally expressed in endothe-lial progenitor cells(EPCs)under hyperglycemia(HG)conditions.The regulatory mechanism and predicted targets of this circRNA were also studied via bioinformatics analysis,luciferase reporter assays,angiogenic differentiation experiments,flow cytometry,and RT-qPCR.Results Circ-astrotactin 1(circ-Astn1)expression was decreased in EPCs under HG conditions,and circ-Astn1 overexpres-sion inhibited HG-induced endothelial damage.The miR-138-5p and silencing information regulator 2 related enzyme 1(SIRT1)were identified as circ-Astn1 downstream targets,which were further verified through luciferase reporter assays.SIRT1 silencing or miR-138-5p overexpression reversed the protective effect of circ-Astn1 on HG-induced endothelial cell dysfunction,as evidenced by increased apoptosis,abnormal vascular differentiation,and inflammatory factor secretion.SIRT1 overexpression reversed miR-138-5p-induced endothelial cell dysfunction under HG conditions.In vivo experiments confirmed that circ-Astnl overexpression promoted skin wound healing through the regulation of SIRT1.Conclusions These findings suggest that circ-Astn1 promotes SIRT1 expression by sponging miR-138-5p.Circ-Astn1 over-expression suppresses HG-induced endothelial cell damage via miR-138-5p/SIRT1 axis. 展开更多
关键词 Circ-Astn1 Endothelial cell Hyperglycemia miR-138-5p SIRT1
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Hyperglycemia-induced overexpression of CREB3 L3 promotes the epithelial-to-mesenchymal transition in bladder urothelial cells in diabetes mellitus 认领 引用
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作者 Qing-Guo Wu Ming-Jin Zhang +2 位作者 Yi-Bi Lan Chun-Lei Ma Wei-Jin Fu 《World Journal of Diabetes》 SCIE 2025年第8期263-284,共22页
BACKGROUND Diabetic cystopathy(DCP)is a complication affecting the lives of people with diabetes.However,the pathogenesis of DCP is not well known.AIM To investigate the potential mechanisms by which cAMP-responsive e... BACKGROUND Diabetic cystopathy(DCP)is a complication affecting the lives of people with diabetes.However,the pathogenesis of DCP is not well known.AIM To investigate the potential mechanisms by which cAMP-responsive elementbinding protein 3 like 3(CREB3 L3)promotes the occurrence and development of DCP.METHODS High-throughput sequencing was used to analyze differentially expressed genes(DEGs)in bladder urothelium from patients with DCP and healthy controls.Gene enrichment analysis was conducted to assess the biological functions of DEG.Small interfering RNA technology was performed to silence the CREB3 L3 gene in both in vitro and in vivo experiments.Morphological changes in bladder urothelium from a DCP rat model were observed.Immunofluorescence and western blotting assay were performed to determine associated protein expression.RESULTS We identified significant DEGs through high-throughput sequencing.These genes were primarily enriched in inflammatory activation,epithelial-mesenchymal transition(EMT)and tight junction organization.Upregulated expression of both CREB3 L3 and C-reactive protein(CRP)in bladder urothelium from patients with DCP was accompanied by upregulated EMT markers including N-cadherin and vimentin proteins,but downregulated E-cadherin.Silencing CREB3 L3 attenuated the protein expression of CRP and EMT in SV-HUC-1 urothelial cells under hyperglycemic conditions and in the diabetes mellitus rat model at 4,8,and 12 weeks.CREB3 L3 knockdown also reversed downregulation of the tight junction proteins occludin and claudin 1.CONCLUSION Hyperglycemia induces the upregulation of CREB3 L3 expression,thereby promoting the EMT and impairing tight junctions in bladder urothelial cells.Targeting CREB3 L3 in bladder urothelial cells is likely to be a key approach in preventing and treating DCP. 展开更多
关键词 Diabetic cystopathy Epithelial-mesenchymal transition Hyperglycemia
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Rapid correction of chronic hyperglycemia and bone remodeling,warning against overdoing 认领 引用
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作者 Dured Dardari Beatrice Segurens 《World Journal of Diabetes》 SCIE 2024年第9期1858-1861,共4页
It is widely recognized that chronic hyperglycemia decreases bone quality,although little is known about the impact of the rapid correction of chronic hyperglycemia on the quality of bone remodeling.This spotlight art... It is widely recognized that chronic hyperglycemia decreases bone quality,although little is known about the impact of the rapid correction of chronic hyperglycemia on the quality of bone remodeling.This spotlight article explores this correlation by focusing on the stages of bone remodeling linked to glucose levels. 展开更多
关键词 Bone remodeling Chronic hyperglycemia Intensive hyperglycemia treatment Diabetes complication Rapid correction of hyperglycemia
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Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia 认领 引用 被引量：25
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作者 Rong-Hui Han He-Meng Huang +9 位作者 Hong Han Hao Chen Fei Zeng Xiang Xie Dan-Yong Liu Yin Cai Liang-Qing Zhang Xin Liu Zheng-Yuan Xia Jing Tang 《Military Medical Research》 SCIE CAS CSCD 2022年第3期286-302,共17页
Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotect... Background:Administration of propofol,an intravenous anesthetic with antioxidant property,immediately at the onset of post-ischemic reperfusion(propofol postconditioning,P-PostC) has been shown to confer cardioprotection against ischemia–reperfusion(I/R) injury,while the underlying mechanism remains incompletely understood.The forkhead box O(FoxO) transcription factors are reported to play critical roles in activating cardiomyocyte survival signaling throughout the process of cellular injuries induced by oxidative stress and are also involved in hypoxic postconditioning mediated neuroprotection,however,the role of FoxO in postconditioning mediated protection in the heart and in particular in high glucose condition is unknown.Methods:Rat heart-derived H9c2 cells were exposed to high glucose(HG) for 48 h,then subjected to hypoxiaeoxygenation(H/R,composed of 8 h of hypoxia followed by 12 h of reoxygenation) in the absence or presence of postconditioning with various concentrations of propofol(P-PostC) at the onset of reoxygenation.After having identified the optical concentration of propofol,H9c2 cells were subjected to H/R and P-PostC in the absence or presence of FoxO1 or FoxO3a gene silencing to explore their roles in P-PostC mediated protection against apoptotic and autophagic cell deaths under hyperglycemia.Results:The results showed that HG with or without H/R decreased cell viability,increased lactate dehydrogenase(LDH) leakage and the production of reactive oxygen species(ROS) in H9c2 cells,all of which were significantly reversed by propofol(P-PostC),especially at the concentration of 25 μmol/L(P25)(P<0.05,NC vs.HG;HG vs.HG+HR;HG+HR+P12.5 or HG+HR+P25 or HG+HR+P50 vs.HG+HR).Moreover,we found that propofol(P25) decreased H9c2 cells apoptosis and autophagy that were concomitant with increased FoxO1 and FoxO3a expression(P<0.05,HG+HR+P25 vs.HG+HR).The protective effects of propofol(P25) against H/R injury were reversed by silencing FoxO1 or FoxO3a(P<0.05,HG+HR+P25 vs.HG+HR+P25+siRNA-1 or HG+HR+P25+siRNA-5).Conclusions:It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia. 展开更多
关键词 Hypoxiaeoxygenation injury Hyperglycemia High glucose Propofol postconditioning Apoptosis Autophagy Forkhead box O
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Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage 认领 引用 被引量：17
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作者 Rong-Yi Liu Jun-Jun Wang +1 位作者 Xia Qiu Ji-Min Wu 《Neuroscience Bulletin》 SCIE CAS CSCD 2014年第1期90-98,共9页
Recent evidence suggests that admission hypergly- cemia has deleterious effects on the survival and functional outcome of patients with intracerebral hemorrhage （ICH）. In this study, we first induced acute hyperglyc... Recent evidence suggests that admission hypergly- cemia has deleterious effects on the survival and functional outcome of patients with intracerebral hemorrhage （ICH）. In this study, we first induced acute hyperglycemia in male adult Sprague-Dawley rats by intraperitoneal injection of 50% glucose （6 mL/kg）, and created the ICH model thereafter by delivering autologous whole blood or homologous normal- glucose blood into the right basal ganglia. Twenty- four hours later, we assessed the neurological injury, evaluated the hematoma and brain water content, and investigated autophagy. We found elevations of neurological deficit scores, brain water content, and microtubule-associated protein light chain-3 （LC3） and beclin-1 protein levels, and decreased SQSTM1/ p62 levels after ICH with normal-glucose blood （without hyperglycemia）. Acute hyperglycemia with ICH of high-glucose blood hematoma was associated with significantly increased forelimb-use asymmetry test scores, brain water content and SQSTM1/p62 protein levels, and evident decreases in the ratio of LC3-11/LC3-1 and beclin-1 protein levels. On the other hand, acute hyperglycemia and ICH with normal- glucose blood hematoma only slightly increased the neurological deficit scores and brain water content （P 〉0.05）. In conclusion, the autophagy pathway was activated after ICH, and acute hyperglycemia with hematoma of high-glucose blood exacerbates the neurological injury, and reduces autophagy around the hematoma. 展开更多
关键词 intracerebral hemorrhage hyperglycemia autophagy
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Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy 认领 引用 被引量：13
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作者 Takanori Hosokawa Masayuki Kurosaki +13 位作者 Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi 《World Journal of Gastroenterology》 SCIE CAS 2013年第2期249-257,共9页
AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was t... AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) therapy.The mean age was 67.6 years and the mean observation period was 4.04 years.The etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 patients.The Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 patients.For surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 mo.Factors associated with distant recurrence of HCC or survival were studied.RESULTS:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant recurrence.The 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of recurrence.The incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic patients.Among 232 patients who had HCC recurrence,138 had a second recurrence.The 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1% vs 24.3%,and 69.6% vs 42.3%,respectively(P = 0.0021).Inadequate maintenance of blood glucose in diabetic patients [1.99(95%CI,1.23-3.22),P = 0.0049] and presence of multiple HCC nodules [1.53(95%CI,1.06-2.22),P = 0.024] were again significantly associated with second HCC recurrence.Inadequate maintenance of blood glucose in diabetic patients was also a significant predictor of poor survival [2.77(95%CI,1.38-5.57),P = 0.0046] independent of excessive alcohol drinking [6.34(95%CI,1.35-29.7),P = 0.019],initial level of serum AFP [3.40(95%CI,1.88-6.18),P < 0.0001] and Child-Pugh classification grade B [2.24(95%CI,1.12-4.46),P = 0.022].Comparing diabetic patients with inadequate maintenance of blood glucose vs the others,the 1-,2-,and 3-year survival rates were significantly lower in diabetic patients with inadequate maintenance of blood glucose:92% vs 99%,85% vs 96%,and 70% vs 92%,respectively(P = 0.0003).CONCLUSION:Inadequate maintenance of blood glucose in diabetic patients is a significant risk factor for recurrence of HCC and for poor survival after curative RFA therapy. 展开更多
关键词 Hyperglycemia Hepatocellular carcinoma Recurrence Radio frequency ablation Survival
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Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat,a spontaneous type 2 diabetic animal model 认领 引用 被引量：5
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作者 WANG Xue LU Qian +5 位作者 YU Dong-Sheng CHEN Yu-Peng SHANG Jing ZHANG Lu-Yong SUN Hong-Bin LIU Jun 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2015年第7期529-534,共6页
The Goto-Kakizaki(GK) rat is a spontaneous type 2 diabetic animal model,which is characterized by a progressive loss of beta islet cells with fibrosis.In the present study,the hypoglycemic effect of asiatic acid(AA) i... The Goto-Kakizaki(GK) rat is a spontaneous type 2 diabetic animal model,which is characterized by a progressive loss of beta islet cells with fibrosis.In the present study,the hypoglycemic effect of asiatic acid(AA) in GK rats was examined.GK rats receiving AA at a daily dose of 25 mg·kg-1 for four weeks showed a significant reduction in blood glucose levels.Age-matched normal Wistar rats were given 0.5% sodium carboxymethyl cellulose(CMC-Na) solution for the same periods and used as control.Compared to the normal Wistar rats,GK rats treated with AA showed improvement in insulin resistance partially through decreasing glucose level(P < 0.01) and insulin level(P < 0.05).Furthermore,the results of immunohistochemistry indicate that AA treatment reduced islet fibrosis in GK rats.Fibronectin,a key protein related to islet fibrosis,was over-expressed in GK rats,which was reversed significantly by AA treatment(P < 0.05).These findings suggest that AA has a beneficial effect on lowering blood glucose levels in GK rats and improves fibrosis of islets in diabetes,which may play a role in the prevention of islets 展开更多
关键词 Asiatic acid Hyperglycemia Islet fibrosis Goto-Kakizaki(GK) rats Diabetes mellitus Pancreas
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Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity 认领 引用 被引量：33
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作者 Federica Ferrari Antonio Moretti Roberto Federico Villa 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第2期292-299,共8页
Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke hyperglycemia is also present in a n... Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke hyperglycemia is also present in a number of non-diabetic patients after acute ischemic stroke, presumably as a stress response. The aim of this review is to summarize the main effects of hyperglycemia when associated to ischemic injury in acute stroke patients, highlighting the clinical and neurological outcomes in these conditions and after the administration of the currently approved pharmacological treatment, i.e. insulin. The disappointing results of the clinical trials on insulin(including the hypoglycemic events) demand a change of strategy based on more focused therapies. Starting from the comprehensive evaluation of the physiopathological alterations occurring in the ischemic brain during hyperglycemic conditions, the effects of various classes of glucose-lowering drugs are reviewed, such as glucose-like peptide-1 receptor agonists, DPP-4 inhibitors and sodium glucose cotransporter 2 inhibitors, in the perspective of overcoming the up-to-date limitations and of evaluating the effectiveness of new potential therapeutic strategies. 展开更多
关键词 acute ischemic stroke diabetes mellitus DPP-4 inhibitor glucose-like peptide-1 receptor agonist hyperglycemia hypoglycemia insulin physiopathology sodium glucose cotransporter 2 inhibitor
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Diacylated anthocyanins from purple sweet potato(Ipomoea batatas L.)attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet 认领 引用 被引量：8
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作者 Luhong SHEN Yang YANG +2 位作者 Jiuliang ZHANG Lanjie FENG Qing ZHOU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2023年第7期587-601,共15页
Studies have shown that targeting xanthine oxidase(XO)can be a feasible treatment for fructose-induced hyperuricemia and hyperglycemia.This study aimed to evaluate the dual regulatory effects and molecular mechanisms ... Studies have shown that targeting xanthine oxidase(XO)can be a feasible treatment for fructose-induced hyperuricemia and hyperglycemia.This study aimed to evaluate the dual regulatory effects and molecular mechanisms of diacylated anthocyanins from purple sweet potato(diacylated AF-PSPs)on hyperglycemia and hyperuricemia induced by a high-fructose/high-fat diet.The body weight,organ index,serum biochemical indexes,and liver antioxidant indexes of mice were measured,and the kidneys were observed in pathological sections.The relative expression levels of messenger RNAs(mRNAs)of fructose metabolism pathway enzymes in kidney were detected by fluorescent real-time quantitative polymerase chain(qPCR)reaction technique,and the expression of renal transporter protein and inflammatory factor pathway protein was determined by immunohistochemistry(IHC)technique.Results showed that diacylated AF-PSPs alleviated hyperuricemia in mice,and that this effect might be related to the regulation of liver XO activity,lipid accumulation,and relevant renal transporters.Diacylated AF-PSPs reduced body weight and relieved lipid metabolism disorder,liver lipid accumulation,and liver oxidative stress,thereby enhancing insulin utilization and sensitivity,lowering blood sugar,and reducing hyperglycemia in mice.Also,diacylated AF-PSPs restored mRNA levels related to renal fructose metabolism,and reduced kidney injury and inflammation.This study provided experimental evidence for the mechanisms of dual regulation of blood glucose and uric acid(UA)by diacylated AF-PSPs and their utilization as functional foods in the management of metabolic syndrome. 展开更多
关键词 Diacylated anthocyanins from purple sweet potato(diacylated AF-PSPs) Hyperglycemia Hyperuricemia Metabolism syndrome Regulation of renal function
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Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury 认领 引用 被引量：6
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作者 Hui-Jie Wei Li Liu +7 位作者 Fang-Lian Chen Dong Wang Liang Wang Zeng-Guang Wang Rong-Cai Jiang Jing-Fei Dong Jie-Li Chen Jian-Ning Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第6期984-990,共7页
Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function.However, the relationship between blood glucose levels and endothelial progenitor c... Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function.However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury,and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels(r =-0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China(approval No. 200501) in January 2015. 展开更多
关键词 nerve regeneration endothelial progenitor cells vascular repair vascular remodeling angiogenesis neovascularization blood glucose hyperglycemia traumatic brain injury mobilization suppression senescence alternative therapy brain damage neural regeneration
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Type 2 Diabetes Meilitus Easily Develops into Alzheimer’s Disease via Hyperglycemia and Insulin Resistance 认领 引用 被引量：4
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作者 Ting LI Hong-xia CAO Dan KE 《Current Medical Science》 SCIE CAS 2021年第6期1165-1171,共7页
With the acceleration of population aging,the incidence of type 2 diabetes mellitus(T2DM)and Alzheimer’s disease(AD)is progressively increasing due to the age-relatedness of these two diseases.The association between... With the acceleration of population aging,the incidence of type 2 diabetes mellitus(T2DM)and Alzheimer’s disease(AD)is progressively increasing due to the age-relatedness of these two diseases.The association between T2DM and AD-like dementia is receiving much attention,and T2DM is reported to be a significant risk factor for AD.The aims of this review were to reveal the brain changes caused by T2DM as well as to explore the roles of hyperglycemia and insulin resistance in the development of AD. 展开更多
关键词 type 2 diabetes mellitus Alzheimer’s disease hyperglycemia insulin resistance cognition
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Successful treatment of hyperglycemia with liraglutide in a hospitalized 27-year-old patient with schizophrenia:A case report 认领 引用 被引量：2
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作者 Lei Zhang Wen-Juan Yu +2 位作者 Hui Zhu Hua-Fang Li Jie Qiao 《World Journal of Clinical Cases》 SCIE 2022年第21期7495-7501,共7页
BACKGROUND Antipsychotics are associated with abnormalities in glucose metabolism in patients with schizophrenia. Liraglutide, a GLP-1 receptor agonist, is Food and Drug Administration approved for the treatment of ty... BACKGROUND Antipsychotics are associated with abnormalities in glucose metabolism in patients with schizophrenia. Liraglutide, a GLP-1 receptor agonist, is Food and Drug Administration approved for the treatment of type 2 diabetes mellitus. However, ways to maintain the long-term stability of psychotic symptoms and balance the disadvantages of obesity, diabetes, and other metabolic disorders caused by antipsychotic medications remain unclear. In this study, we present a case of weight gain and hyperglycemia in a schizophrenia patient who received antipsychotic polypharmacy for 6 years.CASE SUMMARY A 27-year-old man with olanzapine and sodium valproate-treated disorganized schizophrenia was admitted to a diabetes outpatient clinic. He was diagnosed with type 2 diabetes(fasting blood glucose, 20 mmol/L) and obesity(body mass index, 38.58 kg/m). The patient had been treated with glargine(40 IU/d) and metformin(1.5 g/d) and showed a poor response for 2 mo. Two years of liraglutide treatment resulted in stable blood glucose levels and weight loss in addition to a maintained stable mental status for a long time. The biological activities of GLP-1 significantly improved glucose levels and body weight in the schizophrenia patient treated with antipsychotic medications.CONCLUSION Liraglutide administration can be considered an effective alternative treatment for abnormalities in glucose metabolism in schizophrenia patients receiving antipsychotics. 展开更多
关键词 Hyperglycemia Liraglutide GLP-1 receptor agonist Schizophrenia Antipsychotics Case report
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