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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases 认领 引用 被引量：1
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作者 Hang Shu Xiao-Yu Chen +2 位作者 Jie Zhao Pin Li Zhen Sun 《World Journal of Clinical Cases》 2025年第6期14-23,共10页
BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s... BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among others.The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system.The prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic costs.Currently,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and biologics.However,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse reactions.AIM To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.METHODS This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases.Chinese and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine.The quality of the included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using RevMan 5.4 software.RESULTS The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases.The combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective method to reduce the possibility of postoperative recurrence in patients with rheumatic immune diseases.However,due to the limited number and quality of the studies included,these results should be interpreted with caution.CONCLUSION Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective and safe treatment option for patients with rheumatic immune diseases and can be considered a clinical choice.However,more high-quality research is needed to validate this conclusion and provide more solid evidence for clinical practice. 展开更多
关键词 Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis
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Nursing Effect of Skin Ulcer in Patients with Rheumatic Immune Diseases 认领 引用
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作者 TIAN Na FU Beilei 《外文科技期刊数据库（文摘版）医药卫生》 2021年第5期066-068,共3页
Objective: to analyze the effect of holistic nursing intervention on patients with rheumatic immune disease skin ulcer. Methods: in this study, 100 cases of skin ulcer with rheumatic immune disease were randomly divid... Objective: to analyze the effect of holistic nursing intervention on patients with rheumatic immune disease skin ulcer. Methods: in this study, 100 cases of skin ulcer with rheumatic immune disease were randomly divided into two groups. One group was the reference group, which contained 50 patients and received routine nursing. The other group is the experimental group, also contains 50 patients, received the implementation of holistic nursing, and then compared with the nursing effect of patients under different nursing mode. Results: after nursing, the healing time of skin ulcer was calculated and compared. The results showed that the healing time of the experimental group was significantly shorter than that of the reference group (P < 0.05). At the same time, the total therapeutic effect of the experimental group was significantly better than that of the reference group (P < 0.05). Conclusion: under the holistic nursing mode, patients with skin ulcers of rheumatic immune diseases get more significant care, and their skin ulcers recover quickly with obvious curative effect, which is worthy of recommendation. 展开更多
关键词 skin ulcer holistic nursing rheumatic immune diseases nursing effect
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Research on Prevention and Nursing Countermeasures of Pulmonary Complications in Rheumatic Immune Diseases 认领 引用
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作者 XU Ting 《外文科技期刊数据库（文摘版）医药卫生》 2021年第9期739-741,共3页
Objective: to explore the clinical application value of targeted nursing measures in the treatment of patients with rheumatic immune diseases, and provide corresponding reference for clinical practice. Methods: 167 pa... Objective: to explore the clinical application value of targeted nursing measures in the treatment of patients with rheumatic immune diseases, and provide corresponding reference for clinical practice. Methods: 167 patients with rheumatic immune diseases treated in our hospital were selected as objects, and divided into control group and observation group by random number classification methods. Among them, control group 83 cases, during the treatment of routine clinical nursing;observation group 84 patients received targeted nursing during treatment. Then, the nursing effect and nursing satisfaction of patients under the two nursing modes were compared, in order to scientifically select nursing methods for the clinical treatment of the same type of cases, in order to inhibit the occurrence of pulmonary complications in patients. Results: patients received different nursing methods, the treatment of various clinical indicators showed great differences, especially in the total effective rate of nursing and nursing satisfaction, observation group were better than the control group (P < 0.05). Conclusion: the treatment of patients with rheumatoid immune disease, is to give no complications, the most common complications in the treatment process, the scientific implementation of targeted nursing intervention has higher clinical value, not only can effectively improve clinical care efficiently and improve the prognosis of patients with effect, also can improve patient care satisfaction, improve the doctor-patient relationship, is worth wide use in the basic-level hospitals on the floor and even the whole country. 展开更多
关键词 rheumatic immune diseases pulmonary complications quality of life nursing satisfaction
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Clinical Effect Observation of Clinical Nursing Intervention on Patients with Pulmonary Complications in Rheumatic Immune Diseases 认领 引用
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作者 FU Beilei TIAN Na 《外文科技期刊数据库（文摘版）医药卫生》 2021年第4期240-244,共5页
Objective: to explore the clinical effect of clinical nursing intervention on patients with pulmonary complications in rheumatic immune diseases. Methods: a total of 98 patients with rheumatic immune diseases and pulm... Objective: to explore the clinical effect of clinical nursing intervention on patients with pulmonary complications in rheumatic immune diseases. Methods: a total of 98 patients with rheumatic immune diseases and pulmonary complications admitted to our hospital from July 2019 to September 2020 were randomly selected as the research object. They were randomly divided into two groups and then applied with different nursing programs. The analysis group of 49 patients received clinical nursing intervention, and the preset group of 49 patients received routine nursing. The nursing effects of the two groups were compared. Results: the incidence rate of pulmonary complications, hospitalization time and hospitalization expenses of the analysis group were lower than those of the preset group, and the patients' nursing satisfaction was higher than that of the preset group, with significant difference between the groups (P < 0.05). Conclusion: clinical nursing intervention can reduce the risk of pulmonary complications, hospitalization time and treatment costs in patients with rheumatic immune diseases with pulmonary complications. Patients have high satisfaction with nursing and are suitable for promotion. 展开更多
关键词 clinical nursing intervention rheumatic immune diseases pulmonary complications nursing effect
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Effect of Individualized Pain Nursing on Pain Degree of Patients with Rheumatic Immune Diseases 认领 引用
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作者 LIANGJie 《外文科技期刊数据库（文摘版）医药卫生》 2022年第8期137-140,共4页
Objective: to analyze the effect of individualized pain care during the treatment of rheumatic immune diseases. Methods: clinical research was carried out from December 2020 to December 2021. Rheumatic immune diseases... Objective: to analyze the effect of individualized pain care during the treatment of rheumatic immune diseases. Methods: clinical research was carried out from December 2020 to December 2021. Rheumatic immune diseases were taken as the research object. After patients were confirmed to cooperate with the research, the single and even number method was taken as the grouping method of the research. The grouping results showed that there were 60 patients with singular number and 60 patients with even number. The former was in the control group and the latter was in the observation group. The former was in the routine nursing mode and the latter was in the individualized pain nursing. Results: 60 cases in the control group and 60 cases in the observation group participated in the group comparison. When the index was no pain rate, the former was 0.00% and the latter was 13.33%. The index is mild pain rate, the former is 35.00%, the latter is 46.67%;The comparison results showed a difference (P < 0.05). When the index is psychological state, the score of the former is higher and the score of the latter is lower after 7 days of nursing (P < 0.05). When the index is satisfaction degree, the former is 78.33% and the latter is 96.67%, the comparison result is different (P < 0.05). Conclusion: the application of individualized pain care during the treatment of rheumatic immune diseases can achieve ideal effects, such as reducing pain, improving psychology and improving satisfaction. 展开更多
关键词 rheumatic immune disease the former the latter personalized pain care
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Regulation of ISAP on Erythrocyte Sedimentation Rate and C-reactive Protein in Patients with Rheumatic Immune Diseases 认领 引用
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作者 WUXiaojuan 《外文科技期刊数据库（文摘版）医药卫生》 2022年第1期115-118,共4页
Objective: to explore the effect of ISEP on the treatment of rheumatoid arthritis. Methods: the patients with rheumatoid arthritis treated in our hospital from May 2019 to May 2021 were taken as the drug research obje... Objective: to explore the effect of ISEP on the treatment of rheumatoid arthritis. Methods: the patients with rheumatoid arthritis treated in our hospital from May 2019 to May 2021 were taken as the drug research object, and the groups were divided according to the differences of drugs used. 40 patients were divided into the general drug group and the other 40 patients were divided into the comprehensive group. The general drug group used leflunomide and methotrexate, and the latter group added ISEP on the basis of the former group, and compared the symptom relief time of the general drug group and the comprehensive group. The duration of remission and drug satisfaction were compared. Results: in the comprehensive group, the remission was faster, the inflammatory index decreased better, and the patients' self satisfaction was better (P ＜ 0.05). Conclusion: the application of recombinant human type II tumor necrosis factor can achieve better results in patients with rheumatoid arthritis with systemic damage and refractory. 展开更多
关键词 ISEP rheumatic immune disease inflammatory index curative effect
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Application of Clinical Nursing Pathway in the Peri-Treatment Period of Immunoadsorption Therapy for Rheumatic Immune Diseases 认领 引用
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作者 Li Wang Fan Fan Yanrui Ren 《Yangtze Medicine》 2023年第2期87-94,共8页
Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to sele... Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to select inpatients who received immunoadsorption therapy from January 2020 to December 2022 in the rheumatology and Immunology department of a 3A hospital in Jingzhou City. 30 patients from January 2020 to June 2021 were selected as control group, and 30 patients from July 2021 to December 2022 were selected as observation group. The control group was given routine nursing. On the basis of the control group, the observation group used a clinical nursing pathway for intervention during the perioperative period of immunosorbent therapy. The incidence of adverse reactions, patient satisfaction, and nurse satisfaction during immunosorbent therapy between the control group and the observation group were compared. Results: After intervention, the incidence of adverse reactions in the observation group was significantly lower than that in the control group, while patient satisfaction and nurse satisfaction in the observation group were significantly higher than those in the control group. The results are all statistically significant (P Conclusion: Clinical nursing pathway is beneficial to reduce the incidence of adverse reactions in patients with immunoadsorption during peri-treatment and improve the satisfaction of patients and nurses. 展开更多
关键词 Immunoadsorption Clinical Nursing Pathway Rheumatic Immune Disease Peri-Treatment Period
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Application Effect of Refined Management in Nursing Care of Rheumatic Immune Diseases 认领 引用
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作者 TIAN Na FU Beilei 《外文科技期刊数据库（文摘版）医药卫生》 2021年第5期212-214,共3页
Objective: to apply refined management to rheumatic immune diseases, analyze the implementation effect and improve the quality of clinical care. Methods: 120 subjects were included in this study, all of whom belonged ... Objective: to apply refined management to rheumatic immune diseases, analyze the implementation effect and improve the quality of clinical care. Methods: 120 subjects were included in this study, all of whom belonged to rheumatic immune diseases. The patients were randomly divided into two groups by computer. One group was the reference group, which was divided into 60 patients, and the other group was the experimental group, which was equally divided into 60 patients. The reference group adopted the conventional nursing mode, while the experimental group adopted the refined management mode, and compared the application effects obtained under different nursing modes. Results: the improvement of psychological state and nursing satisfaction of the experimental group were significantly better than those of the reference group (P < 0.05). Conclusion: refined management intervention on rheumatic immune diseases can promote the improvement of patients' psychological state, actively cooperate with doctors for treatment, improve patients' satisfaction with nursing care, and build a harmonious nurse-patient relationship, which is worthy of recommendation. 展开更多
关键词 refined management rheumatic immune disease nursing effect
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Autoimmune Hepatitis Associated with Other Autoimmune Diseases:A Critical Review 认领 引用 被引量：1
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作者 Danzhu Zhao George Y.Wu 《Journal of Clinical and Translational Hepatology》 SCIE CSCD 2025年第10期869-877,F0003,共9页
Autoimmune hepatitis(AIH)is an inflammatory liver disease influenced by genetic,environmental,and immunologic factors.Individuals diagnosed with AIH may exhibit concurrent autoimmune manifestations affecting multiple ... Autoimmune hepatitis(AIH)is an inflammatory liver disease influenced by genetic,environmental,and immunologic factors.Individuals diagnosed with AIH may exhibit concurrent autoimmune manifestations affecting multiple organ systems.The prevalence of AIH associated with other autoimmune diseases has been reported to range from 20%to 40%.This review indicates that the associations between AIH and autoimmune thyroiditis,type 1 diabetes mellitus,ulcerative colitis,Crohn disease,and celiac disease appear to be significant.However,the associations between AIH and primary sclerosing cholangitis,primary biliary cholangitis,rheumatoid arthritis,systemic lupus erythematosus,Sjögren syndrome,and vitiligo are not well-supported.The aim of this review is to evaluate the strength of the reported associations between AIH and other autoimmune diseases,and to update and present the available evidence on their prevalence,proposed underlying pathogenic mechanisms,diagnostic considerations,and treatment approaches. 展开更多
关键词 Autoimmune hepatitis Autoimmune diseases Immune system diseases Genetic predisposition to disease Prevalence Diagnostics Treatment.
Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases 认领 引用 被引量：15
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作者 Morten L Halling Jens Kjeldsen +2 位作者 Torben Knudsen Jan Nielsen Lars Koch Hansen 《World Journal of Gastroenterology》 SCIE CAS 2017年第33期6137-6146,共10页
AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive... AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact test.RESULTS There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways. 展开更多
关键词 Immune mediated diseases Ulcerative colitis Risk Prevalence Registry Chronic inflammatory diseases Autoimmune diseases Inflammatory bowel disease Crohn’s disease extraintestinal manifestations
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Application Effect of Comprehensive Nursing in Clinical Nursing of Rheumatic Immune System Diseases 认领 引用
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作者 WANG Min HAN Shuangshuang 《外文科技期刊数据库（文摘版）医药卫生》 2021年第5期131-133,共3页
Objective: to explore the clinical effect of comprehensive nursing in patients with rheumatic immune system diseases. Methods: 80 patients with rheumatic immune system diseases who received treatment in our hospital f... Objective: to explore the clinical effect of comprehensive nursing in patients with rheumatic immune system diseases. Methods: 80 patients with rheumatic immune system diseases who received treatment in our hospital from January 2020 to January 2021 were selected and randomly divided into observation group and control group with 40 patients in each group. The observation group was treated with traditional nursing while the control group was treated with comprehensive nursing. The nursing effects of patients were compared and observed. Results: the VAS, pain score and nursing satisfaction of the observation group were better than those of the control group, the difference was statistically significant. Conclusion: comprehensive nursing has good effect in patients with rheumatic immune system and should be widely applied. 展开更多
关键词 comprehensive care rheumatic immune system diseases clinical nursing application effect
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Multiple immune disorders in unrecognized celiac disease:a case report 认领 引用 被引量：3
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作者 Giorgio LaVilla Pietro Pantaleo +4 位作者 Roberto Tarquini Lino Cirami Federico Perfetto Francesco Mancuso Giacomo Laffi 《World Journal of Gastroenterology》 SCIE CAS 2003年第6期1377-1380,共4页
We reported a female patient with unrecognized celiac disease and multiple extra intestinal manifestations, mainly related to a deranged immune function, including macroamilasemia, macrolipasemia, IgA nephropathy,thyr... We reported a female patient with unrecognized celiac disease and multiple extra intestinal manifestations, mainly related to a deranged immune function, including macroamilasemia, macrolipasemia, IgA nephropathy,thyroiditis, and anti-b2-glicoprotein-1 antibodies, that disappeared or improved after the implementation of a gluten-free diet. 展开更多
关键词 Abortion, Habitual Adult Celiac Disease Diet Female Glomerulonephritis, IGA Gluten dosage Humans Hyperamylasemia Immune System Diseases Lipase Thyroiditis, Autoimmune
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Tumor necrosis factor-alpha in experimental autoimmune neuritis 认领 引用
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作者 Xijing Mao Hongliang Zhang Jie Zhu 《Neural Regeneration Research》 SCIE CAS 2010年第1期70-78,共9页
Tumor necrosis factor-α (TNF-α) plays a key role in the pathogenesis of experimental autoimmune neuritis (EAN) as well as Guillain-Barre syndrome. The proposed pathogenesis of TNF-α associated neuropathies involves... Tumor necrosis factor-α (TNF-α) plays a key role in the pathogenesis of experimental autoimmune neuritis (EAN) as well as Guillain-Barre syndrome. The proposed pathogenesis of TNF-α associated neuropathies involves immune-mediated attack to blood-nerve barrier, aggravated production of pro-inflammatory cytokines, and the induction of Schwann cells apoptosis. TNF-α may play a regulatory role by increasing production of interleukin-1 in macrophages, attenuating T cell receptor signaling and regulating apoptosis of potentially autoreactive T cells in EAN. The data suggest that antagonizing TNF-α functions or suppressing TNF-α production may be useful in the acute phase of EAN treatment, but further studies are required. 展开更多
关键词 tumor necrosis factor-α experimental autoimmune neuritis Guillain-Barre syndrome autoimmune neurobiology immune disease review
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Research Progress of Intestinal Flora and Related Diseases 认领 引用
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作者 Yaping Sun Xindi Zhang +3 位作者 Yanli Zhang Yanpo Si Bing Cao Zengfu Shan 《Chinese Medicine and Natural Products》 CAS 2023年第3期108-116,共9页
The intestinal tract is an important digestive organ and detoxification organ of the human body,and its circling structure is vividly called the“second brain”of the human body.There are hundreds of millions of bacte... The intestinal tract is an important digestive organ and detoxification organ of the human body,and its circling structure is vividly called the“second brain”of the human body.There are hundreds of millions of bacterium in the intestinal tract.These bacteria live in mutual benefit with the body,provide energy and nutrients for the host and themselves through fermented food,participate in the metabolism of the body,and form a metabolic mode of cometabolism between the host and the symbiotic flora.In addition,intestinal flora can also help the body resist the invasion of pathogens,promote human health,and resist diseases.More and more studies have shown that when the body is subjected to exogenous or endogenous stimuli,the microbial flora in the intestinal will change,and the disturbance of intestinal flora is closely related to the occurrence and development of inflammatory bowel diseases,metabolic diseases,immune system diseases,mental system diseases,and tumors.This article reviews the research progress of the intestinal flora affecting the pathogenesis of various diseases,aiming to provide new references and ideas for the clinical treatment of diseases. 展开更多
关键词 intestinal flora metabolic diseases bowel diseases mental system diseases immune diseases tumors
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Comparison of Immune Effect of Four Commercial Marek's Disease Vaccines in Wenchang Chicken 认领 引用
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作者 Cao Zongxi Zhang Yan +2 位作者 Tan Shuyi Ye Baoguo Lin Zhemin 《Animal Husbandry and Feed Science》 CAS 2015年第1期18-20,共3页
Marek＇s disease（MD） is a lymphoproliferative disease of domestic chickens caused by a highly infectious,oncogenic alpha-herpesvirus known as Marek＇s disease virus（MDV）.The aim of this study was to compare the ef... Marek＇s disease（MD） is a lymphoproliferative disease of domestic chickens caused by a highly infectious,oncogenic alpha-herpesvirus known as Marek＇s disease virus（MDV）.The aim of this study was to compare the efficacy of four commercial MDV vaccines in Wenchang chicken.The 1-day old Wenchang chickens tested were injected with one of four different vaccines or not unvaccinated as control;five days later,they were then challenged by virulent MDV strain MD5.The results showed that,in comparison with HVT vaccines,the CVI988 vaccine gave the immunized chickens more potent immunities against challenges of MDV strain MD5. 展开更多
关键词 Marek＇s disease virus Wenchang chicken Immunity efficacy Comparative trial
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Autoantibodies Targeting Vinculin Reveal Novel Insight into the Mechanisms of Autoimmune Podocytopathies 认领 引用 被引量：2
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作者 Hanyan Meng Dongjie Wang +9 位作者 Chen Zheng Chao Zhou Xinrui Mao Jinglan Gu Xiaohui Qiao Fei Liu Jingjing Wang Haidong Fu Jianhua Mao Qing Ye 《Research》 SCIE EI CSCD 2026年第2期270-284,共15页
Background:Emerging evidence suggests that autoantibodies targeting podocytes are potential contributors to idiopathic nephrotic syndrome(INS);however,the specific mechanisms remain unclear.This study aims to explore ... Background:Emerging evidence suggests that autoantibodies targeting podocytes are potential contributors to idiopathic nephrotic syndrome(INS);however,the specific mechanisms remain unclear.This study aims to explore the pathogenic role and underlying mechanisms of anti-vinculin autoantibodies in INS.Methods:Serum anti-vinculin autoantibody levels detected by protein microarray and clinical data were compared among INS patients(n=147),healthy individuals(n=84),and patients with other kidney or immune diseases(n=100 of each disease).Immune-mediated mouse models were established to verify the pathogenicity of anti-vinculin autoantibodies.Mouse urine was monitored for urine protein levels,while immunofluorescence,pathological staining,and electron microscopy assessed kidney pathological and ultrastructural changes.Transcriptome sequencing of mouse kidney tissues was performed to investigate the key molecular mechanisms and signaling pathways involved in kidney injury postimmunization.Results:Anti-vinculin autoantibody levels were specifically elevated in INS patients,with a 54.42%positivity rate,correlating with urinary albumin,serum albumin,cholesterol,and CD19 levels.The average anti-vinculin autoantibody levels dropped markedly in pediatric INS patients during remission.Mouse experiments revealed that injecting anti-vinculin antibodies or recombinant vinculin protein induced proteinuria and podocyte injury in the immunized mice,and the renal phenotype closely resembled the pathological characteristics of minimal change disease.Transcriptome sequencing of renal tissues revealed up-regulation of inflammation,immune responses,cytokine activities,and B cell activation pathways in the immunized mice,while cytoskeleton-related functions were down-regulated.Conclusions:Autoantibodies targeting vinculin act as pathogenic autoantibodies in INS and hold potential value for diagnosing and monitoring INS progression. 展开更多
关键词 vinculin idiopathic nephrotic syndrome ins howeverthe protein microarray autoantibodies targeting podocytes kidney immune diseases autoimmune podocytopathies autoantibodies idiopathic nephrotic syndrome
Complement Protection Against Immune Complex and Acute Glomerulonephritis 认领 引用
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作者 Hu Mingchang Jiang Xinyou.ACTA ACADEMIAE MEDICINAE NANJING,1994, 14:19-21 《Journal of Biomedical Research》 CAS 1994年第1期48-48,共1页
in this study serum complement mediated immune complex solubilizing capacity (CMSC) and immune complement precipitation capacity (ICPIC) of 32 children with acute glomerulonephritis (AGN) were measured. The data showe... in this study serum complement mediated immune complex solubilizing capacity (CMSC) and immune complement precipitation capacity (ICPIC) of 32 children with acute glomerulonephritis (AGN) were measured. The data showed that the level of serum CMSC and ICPIC was markedly decreased in acute phase and returned to normal in the 7th week after onset of disease.Correlation analysis revealed that there were positive correlation between the level of serum CMSC and ICPIC and the serum concentration of CH50, C3, C4, but no linear correlation between the level of serum CMSC and ICPIC and the amount of CIC. These results suggest that the declined serum CMSC and ICPIC in AGN may be associ ated with the pathogenesis of AGN. 展开更多
关键词 Glomerulonephritis, acute complement immune complex disease complement mediated immune complex solubilizing capacity immune complex precipitation inhibi-tion capacity
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Analysis of Curative Effect of Hydroxychloroquine in the Treatment of Pregnancy with Rheumatoid Immune Disease 认领 引用
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作者 CHEN Si GUO Yunzhong +1 位作者 LIU Yiting YE Wenhui 《外文科技期刊数据库（文摘版）医药卫生》 2021年第12期353-355,共3页
Objective: to analyze the safety of hydroxychloroquine in the treatment of rheumatoid immune disease in pregnancy. Methods: from April 2013 to April 2020, during the hospitalized patients in 86 cases of pregnancy with... Objective: to analyze the safety of hydroxychloroquine in the treatment of rheumatoid immune disease in pregnancy. Methods: from April 2013 to April 2020, during the hospitalized patients in 86 cases of pregnancy with rheumatism patients as the research object, all staff can be divided into the experimental group and the control group, control group patients implementation of small dose of hormone therapy, patients use hormone treatment plus hydroxychloroquine, comparison and analysis the curative effect of two groups of patients after drug use. Results: in this experimental study, 90.70% of the patients in the experimental group through treatment, the clinical symptoms have been effectively improved, the control group of patients is 72.09%, the treatment effect of the experimental group of patients is more effective than the control group, compare the difference between the two groups in the medical difference (P＜0.05). Conclusion: hormone and hydroxychloroquine can effectively improve the clinical symptoms of patients with rheumatic immune diseases in pregnancy, which is beneficial to alleviate and improve the pain of patients, and improve the quality of life and work, which has an important significance in clinical application. 展开更多
关键词 hydroxychloroquine pregnancy rheumatic immunity disease clinical curative effect
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Application of Clinical Nursing Pathway Combined with Cluster Nursing Mode in Biologic Treatment of Rheumatoid Immune Disease Patients 认领 引用
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作者 Li Wang Wan Liu Yanrui Ren 《Yangtze Medicine》 2022年第3期76-82,共7页
Objective: To investigate the effect of clinical nursing pathway (CNP) combined with cluster nursing mode in intravenous biologic treatment of rheumatoid immune disease patients. Methods: Convenience sampling method w... Objective: To investigate the effect of clinical nursing pathway (CNP) combined with cluster nursing mode in intravenous biologic treatment of rheumatoid immune disease patients. Methods: Convenience sampling method was used to select inpatients receiving biologics treatment in Rheumatology and Immunology Department of a grade A hospital in Jingzhou city from May 2020 to April 2022. 75 patients from May 2020 to April 2021 were selected as the control group, and 75 patients from May 2021 to April 2022 were selected as the observation group. The control group was given routine care. The observation group was treated with CNP combined with cluster nursing mode on the basis of the control group, and the incidences of adverse infusion reactions, total treatment time, patient satisfaction and nurse satisfaction were compared between the two groups. Results: There were statistically significant differences between the two groups after intervention (P Conclusion: Using CNP combined with cluster nursing mode is beneficial to reduce the incidence of adverse infusion reactions in patients, shorten the total treatment time, and improve the satisfaction of patients and nurses. 展开更多
关键词 Biologic Treatment Clinical Nursing Pathway Cluster Nursing Rheumatoid Immune Disease
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Analysis of Clinical Characteristics of Rheumatic Immune Disease Complicated with Thrombocytopenia 认领 引用
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作者 DOUYingying CUIWenjuan SUNWei 《外文科技期刊数据库（文摘版）医药卫生》 2022年第5期001-004,共4页
Objective: to explore and analyze the clinical characteristics of rheumatic immune disease complicated with thrombocytopenia. Methods: from October 2019 to September 2021, 108 cases of rheumatic immune patients admitt... Objective: to explore and analyze the clinical characteristics of rheumatic immune disease complicated with thrombocytopenia. Methods: from October 2019 to September 2021, 108 cases of rheumatic immune patients admitted to our hospital were selected as the investigation objects, among which 58 cases with thrombocytopenia were selected. The clinical status of rheumatic immune diseases with thrombocytopenia was summarized by comparing the thrombocytopenia, hemorrhage degree and the clinical response of platelets under various treatments of these patients. Results: sjogren's syndrome was the most common type of patients. The clinical effect of general immunosuppressive agents was poor after hormone addition. Leflunomide was improved, platelet was increased and spontaneous hemorrhage was stopped. Conclusion: systemic lupus erythematosus, Sjogren's syndrome and other diseases have a high incidence rate in rheumatic diseases complicated with thrombocytopenia, among which the Sjogren's complications have the greatest impact on thrombocytopenia. The clinical effect is not obvious under the treatment of hormone dosage or general immunosuppressive agents, but flunomide can be selected with good effect. 展开更多
关键词 rheumatism immune disease thrombocytopenia clinical characteristics
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