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Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots 认领 引用 被引量：11
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作者 Lingjie Meng Qinglan Guo +3 位作者 Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第8期1257-1260,共4页
A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A（1）, was isolated from an aqueous extract of the Isatis indigotica roots ＂ban lan gen＂. Its structure was elucidated by... A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A（1）, was isolated from an aqueous extract of the Isatis indigotica roots ＂ban lan gen＂. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism（CD） data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. 展开更多
关键词 Isatis indigotica Cruciferae Ban lan gen Indole-lignan conjugate Isatindolignanoside A Antiviral activity
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