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Excellent mechanical properties and biocompatibility of Ti-15Mo alloy via interstitial nitrogen atoms 认领 引用
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作者 Zhizhi Wang Pei Liu +3 位作者 Jingyi Guo Yiwen Yan Aiqin Wang Jingpei Xie 《Metals Advances》 SCIE EI CAS CSCD 2026年第1期38-46,共9页
The insufficient tensile yield strength is a prominent deficiency for metastable biomedical titanium alloys from the clinical application perspective.In this study,we have reported a strategy to obtain excellent mecha... The insufficient tensile yield strength is a prominent deficiency for metastable biomedical titanium alloys from the clinical application perspective.In this study,we have reported a strategy to obtain excellent mechanical properties and biocompatibility of the Ti-15Mo alloy via interstitial nitrogen atoms.The results show that the addition of a trace amount of 0.1 wt%nitrogen atoms into Ti-15Mo alloy could significantly increase the tensile yield strength(YS)from 370 MPa to 995 MPa,while retaining a moderate elongation of 15.7%and an elastic modulus of 91.1 GPa.The obvious enhancement of tensile yield strength is mainly attributed to the grain refinement,twinning obstruction and dislocation pinning induced by interstitial nitrogen atoms.While the moderate plasticity is mainly because the introduction of nitrogen atoms could effectively inhibit the precipitation of nano-sizedωphases,thereby promoting remarkable dislocation slip.Moreover,the addition of interstitial nitrogen atoms could preserve the excellent in vitro biocompatibility of Ti-15Mo alloy,manifesting as elevated optical density(OD)values and increased filopodia and pseudopodia lengths.The insights derived from these findings are valuable for designing biomedical titanium alloys that possess excellent mechanical properties and biocompatibility. 展开更多
关键词 β-type titanium alloys Interstitial nitrogen Deformation mechanism Biocompatibility
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Insights into PMS activation mechanism by Te-Co3O4-α for levofloxacin removal:Role of interstitial and substitutional doping 认领 引用
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作者 Jianke Tan Xiaodan Zhang Yuming Huang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期825-833,共9页
The correlation between the distinct doping modalities of heteroatoms in metal oxides and the activation pathways of peroxymonosulfate(PMS)remains underappreciated.To address the issue,herein,we synthesized Te-doped C... The correlation between the distinct doping modalities of heteroatoms in metal oxides and the activation pathways of peroxymonosulfate(PMS)remains underappreciated.To address the issue,herein,we synthesized Te-doped Co3O4-αvia a simple hydrothermal method and employed it as a heterogeneous catalyst for PMS activation to degrade levofloxacin(LEV).The incorporation of Te via both interstitial and substitutional doping synergistically enhanced the activity of Co3O4toward PMS activation,resulting in a 66-fold increase in the LEV degradation kinetics.Various characterizations and trial results revealed that the coexistence of these doping configurations unlocked multiple pathways for reactive species generation.Interstitial Te dominates the formation of radicals and singlet oxygen(1O2),and synergistically cooperates with the generated oxygen vacancies to promote the cyclic regeneration of low-valent Co sites.On the other hand,substitutional Te primarily tailors the electron density of Co atoms through Co-O-Te sites,driving the formation of high-valent Co(Ⅳ)=O species.The factors affecting the LEV degradation were investigated,and the potential applications of the Te-Co3O4-α/PMS system were explored.Also,LEV degradation pathways were discussed.This work elucidates the correlation between doping modalities and PMS activation pathways,rendering a novel strategy to develop high performance catalysts for PMS activation. 展开更多
关键词 Peroxymonosulfate Activation pathway Interstitial doping Substitutional doping Oxygen vacancy
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The effect of Sambucus nigra extract in the treatment of interstitial cystitis 认领 引用
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作者 Arif Kol Hüseyin Günizi Özlem Ceren Günizi 《The Canadian Journal of Urology》 SCIE 2026年第3期675-684,共10页
Objective:Sambucus nigra(SN)has been found to exhibit strong antioxidant properties and antiinflammatory effects.In our study,we aimed to investigate the therapeutic effects of Sambucus nigra extracts(SNe)in interstit... Objective:Sambucus nigra(SN)has been found to exhibit strong antioxidant properties and antiinflammatory effects.In our study,we aimed to investigate the therapeutic effects of Sambucus nigra extracts(SNe)in interstitial cystitis,a condition in which inflammation plays a significant role in its pathophysiology.Methods:Thirty Wistar albino adult female rats were used in this study.All rats were housed at an average room temperature of 23◦C,with a 12-h light/dark cycle,and had ad libitum access to food.The rats were divided into three groups:Group 1(n=10):Control(sham)group,Group 2(n=10):Interstitial cystitis group,and Group 3(n=10):Treatment group.Rats in Group 3 were administered oral Sambucus nigra extract at a dose of 0.040 g/kg every other day for a total of 8 weeks.Bladder tissues were examined both histologically and immunohistochemically,with a focus on mast cells and the presence of Interleukin-6(IL-6),Interleukin-8(IL-8),Vascular Endothelial Growth Factor(VEGF),and Tumor Necrosis Factor-α(TNF-α).Results:The findings of chronic inflammation were striking in the bladder sections of the interstitial cystitis group.In the treatment group,regenerating transitional epithelium,a compact appearance in the lamina propria,and a decrease in inflammatory cells and mast cells were observed.While significant improvements were noted in IL-8,TNF-α,and mast cell counts,there was a reduction in IL-6 and VEGF levels,although this reduction was not statistically significant.Conclusion:Sambucus nigra,significantly reduces TNF-α,Mast cell,VEGF,IL-6,and IL-8 levels in interstitial cystitis(IC)bladder tissue.It provides recovery in damaged bladder epithelium,smooth muscle,and basal membrane.SN attracts attention as an important agent due to its effects in the treatment of IC. 展开更多
关键词 interstitial cystitis Sambucus nigra inflammation interleukin-8 tumor necrosis factor-α
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Neonatal bone marrow interstitial fluid supports expansion and osteogenic ability of human bone marrow mesenchymal stromal cells 认领 引用
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作者 Junfeng Zhang Tengjiao Ma +5 位作者 Lan Ke Huan Zhang Jiaxin Hu Shunping Li Hailong Wang Anming Meng 《Bone Research》 SCIE CAS CSCD 2025年第6期1599-1612,共14页
The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells,which are essential for bone development and regeneration.However,the composition and potential use of bone m... The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells,which are essential for bone development and regeneration.However,the composition and potential use of bone marrow interstitial fluid have not been well explored.In this study,we report the role of neonatal bovine bone marrow interstitial fluid(NBIF)in enhancing the bone regeneration capacity of human bone marrow mesenchymal stem cells(hBMSCs).Unlike adult bovine bone marrow interstitial fluid(ABIF),NBIF-fed hBMSCs exhibit enhanced self-renewal and osteogenic potential and bone marrow homing ability,along with transcriptome changes as compared to hBMSCs cultured in standard fetal bovine serum(FBS)supplemented medium.Mass spectrometry analysis reveals that multiple secreted factors associated with tissue repair and bone development are enriched in NBIF compared to FBS and ABIF.The combined use of NBIF-enriched Nerve Growth Factor(NGF),Lactoferrin(LTF),and High Mobility Group Protein B1(HMGB1),together with Insulin-Like Growth Factor 1(IGF1)for culturing hBMSCs in the presence of FBS can enhance osteogenic potential and bone marrow homing ability,mimicking NBIF's effects.These findings highlight the role of interstitial fluid in the bone marrow microenvironment and its potential to optimize stem cell-based therapies. 展开更多
关键词 human bone marrow mesenchymal stem cells bone marrow interstitial fluid enhancing bone regeneration capacity bone marrow interstitial fluid nbif neonatal bovine bone marrow interstitial fluid osteogenic potential human bone marrow mesenchymal stem cells hbmscs unlike bovine bone marrow interstitial fluid abif nbi
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Correlation between positive degree and psychological distress in patients with interstitial lung disease 认领 引用
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作者 Ying Ding Tian-Yu Chen +5 位作者 Su-Hong Wang Xi-Yao Chen Long Zhang Jun-Kang Huang-Fu Jun Zhou Shu-Hong Guan 《World Journal of Psychiatry》 SCIE 2026年第6期357-367,共11页
BACKGROUND Extant studies have explored the independent influencing factors of positivity or psychological distress in patients with interstitial lung disease(ILD);however,few studies have hitherto systematically anal... BACKGROUND Extant studies have explored the independent influencing factors of positivity or psychological distress in patients with interstitial lung disease(ILD);however,few studies have hitherto systematically analyzed the correlation between positivity or psychological distress in these patients.AIM To explore the correlation between disease management positivity and psychological distress in patients with ILD.METHODS Convenience sampling was used to select 370 patients with ILD treated in The First People’s Hospital of Changzhou(The Third Affiliated Hospital of Soochow University)from July 2023 to January 2025.We obtained data via a general information questionnaire,the Patient Activation Measure(PAM),and Kessler Psychological Distress Scale(K10).Pearson’s correlation analysis was conducted to assess the correlation between positivity and psychological distress.Multiple linear regression analyzed the factors that affected psychological distress.A restricted cubic spline model examined the dose-response relationship between the PAM and K10 scores.RESULTS The total PAM and K10 scores were 50.51±5.48 and 32.62±5.60,respectively.Significant differences were observed in the K10 scores among patients based on education level,dyspnea level,and the Perceived Social Support Scale score(P<0.05).Psychological distress was negatively correlated with cognition,action,belief,skill,and the PAM score(all P<0.05).Multiple linear regression analysis identified education level,dyspnea,Perceived Social Support Scale score,and PAM score as the main factors that influenced psychological distress(P<0.05).Restricted cubic spline curve fitting indicated a negative linear relationship between the PAM and K10 scores,adjusted for covariates(P for overall<0.001,P for non-linear=0.188).CONCLUSION Positivity is negatively correlated with psychological distress in patients with ILD.Clinically,attention should be paid to patients’psychological state to enhance their positivity. 展开更多
关键词 Interstitial lung disease Positiveness Psychological distress Correlation Restricted cubic spline Influencing factors
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Renal tubular acidosis complication of non-steroidal antiinflammatory drugs induced interstitial nephritis and its complete resolution with steroids:A case report 认领 引用
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作者 Abhisekh Sinha Ray Praveen Errabelli +1 位作者 Neeharik Mareedu Maulik K Lathiya 《World Journal of Nephrology》 2026年第1期265-273,共9页
BACKGROUND Non-steroidal anti-inflammatory drugs(NSAIDs)are extensively utilized for their analgesic and anti-inflammatory properties;however,their potential to induce renal adverse events remains a significant clinic... BACKGROUND Non-steroidal anti-inflammatory drugs(NSAIDs)are extensively utilized for their analgesic and anti-inflammatory properties;however,their potential to induce renal adverse events remains a significant clinical concern.NSAID-induced interstitial nephritis(IN)and renal tubular acidosis(RTA)are rare but important complications of prolonged NSAID consumption.NSAID-induced RTA has been documented in limited case reports and usually resolves after stopping NSAIDs.However,our case shows a persistent,severe hypokalemia and hypophosphatemia linked to RTA from NSAID-induced IN,which resolved with steroid therapy.CASE SUMMARY A 70-year-old woman with a history of chronic NSAID use presented with weakness and palpitations.She had atrial fibrillation,severe hypokalemia(K 1.5 mmol/L),non-anion gap metabolic acidosis(HCO311 mmol/L,anion gap 11),hypophosphatemia(1.2 mg/dL),acute kidney injury(creatinine 2 mg/dL from 0.6),and rhabdomyolysis(creatine kinase 15620 U/L).Urinalysis showed pH 6.5,proteinuria,sterile pyuria,and a positive urine anion gap,indicating RTA.Electrolytes improved with supplementation and spironolactone,but didn’t normalize.At 4 weeks post-hospitalization,she still required supplementation;creatinine remained high.Renal biopsy revealed interstitial inflammation with active tubulitis,moderate interstitial fibrosis,and tubular atrophy.She was treated with 4 weeks of prednisone,leading to normalized electrolytes and improved creatinine(1 mg/dL),and the improvements were sustained 6 months post-treatment.CONCLUSION Our patient exhibited persistent metabolic disturbances even after the cessation of NSAID therapy.Despite moderate chronicity,active interstitial inflammation responded favorably to corticosteroid treatment,resulting in improved renal function and restoration of tubular function,with normalization of acid-base and electrolyte parameters. 展开更多
关键词 Interstitial nephritis Non-steroidal anti-inflammatory drugs Renal tubular acidosis Hypokalemia Steroids Tubular dysfunction Case report
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Connecting sugar and fibrosis:Diabetes as a hidden player in rheumatoid arthritis-associated interstitial lung disease 认领 引用
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作者 Lucas Casagrande Passoni Lopes 《World Journal of Clinical Cases》 2026年第1期1-5,共5页
Rheumatoid arthritis(RA)is a chronic systemic autoimmune disease that extends beyond joint inflammation,affecting pulmonary and metabolic pathways.Interstitial lung disease(ILD)is one of its most serious extra-articul... Rheumatoid arthritis(RA)is a chronic systemic autoimmune disease that extends beyond joint inflammation,affecting pulmonary and metabolic pathways.Interstitial lung disease(ILD)is one of its most serious extra-articular complications,while type 2 diabetes mellitus(T2DM)frequently coexists with RA and may exacerbate inflammatory and fibrotic processes.This editorial discusses the study by Sutton et al,the largest population-based analysis to date exploring the link between T2DM and ILD in patients with RA,and reflects on its mechanistic and clinical implications.In a nationwide cohort of more than 120000 hospitalized RA patients,Sutton et al demonstrated that the coexistence of T2DM nearly doubles the odds of developing ILD(odds ratio=2.02;95%confidence interval:1.84-2.22),with additional increases in pulmonary hypertension,pneumothorax,and length of stay.These findings reinforce the concept of a metabolic-pulmonary-autoimmune axis,in which chronic inflammation promotes insulin resistance and metabolic dysfunction,while hyperglycaemia and advanced glycation end-products amplify oxidative stress and fibrogenesis.This reciprocal interaction may induce a self-perpetuating cycle of“metaflammation”,fibrosis,and organ damage.Conclusion:Recognizing diabetes as a silent amplifier of RA-associated ILD redefines the interface between rheumatology,pulmonology,and endocrinology.Early detection and integrated management of metabolic and pulmonary comorbidities should be prioritized,while future studies must determine whether optimizing glycemic control can attenuate pulmonary fibrosis and improve longterm outcomes. 展开更多
关键词 Fibrosis Metaflammation Pathophysiology Interstitial lung disease Rheumatoid arthritis Type 2 diabetes mellitus
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Atomic-scale understanding of interstitial-strengthened high-entropy alloys 认领 引用 被引量：4
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作者 Qiang Yu Shi Qiu Zeng-Bao Jiao 《Rare Metals》 SCIE EI CAS CSCD 2025年第9期6002-6014,共13页
Interstitial alloying has emerged as a powerful strategy to tune microstructure and microproperties of high-entropy alloys(HEAs) due to the strong interaction of interstitials with constituent elements and crystal def... Interstitial alloying has emerged as a powerful strategy to tune microstructure and microproperties of high-entropy alloys(HEAs) due to the strong interaction of interstitials with constituent elements and crystal defects,which enables the development of advanced alloys with superior mechanical and functional properties. The paper reviews the latest progress in the atomic-scale understanding of the effects of various interstitials, including carbon, boron, nitrogen, oxygen, and hydrogen, on the microstructure, stability, mechanical properties, and deformation behavior of HEAs. Emphases are placed on the in-depth insights on the interaction of interstitials with constituent elements and crystal defects, such as vacancies,stacking faults, and grain boundaries. Key parameters for rapid prediction of intrinsic properties of HEAs are also discussed. Finally, we highlight some unsolved issues and provide perspectives for future research directions. 展开更多
关键词 High-entropy alloy Interstitial Atomistic modeling Mechanical property Deformation mechanism
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Interstitial oxygen solutes promote atomic-scale heterogeneities to achieve superior irradiation tolerance in body-centered cubic multi-principal element alloys 认领 引用 被引量：2
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作者 Zhengxiong Su Jinxue Yang +10 位作者 Xiaoyang Zhou Jing Li Ping Zhang Chen Zhang Tan Shi Ke Jin Yongduo Sun Lu Wu Xiaoyong Wu En Ma Chenyang Lu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第24期142-154,共13页
Designing alloys capable of withstanding irradiation is a crucial aspect of developing materials for nuclear reactors and aerospace applications.Local chemical order(LCO)has recently been recognized as a new microstru... Designing alloys capable of withstanding irradiation is a crucial aspect of developing materials for nuclear reactors and aerospace applications.Local chemical order(LCO)has recently been recognized as a new microstructural parameter to leverage,and its effect on the mechanical properties of body-centered cubic(BCC)multi-principal element alloys(MPEAs)has attracted much attention.However,the impact of LCO on the dynamic evolution of irradiation-induced defects in BCC MPEAs remains much less explored.In this study,we engineered varying degrees of LCO and local lattice distortion in NbZrTi BCC MPEAs by alloying them with different concentrations of interstitial oxygen solutes,and analyzed their effects on the evolution of radiation-induced defects during He irradiation at 673 K to 873 K,with a fluence of 5×1016 ions/cm2 and a peak dose of approximately 1 DPA.Using first-principles calculations and atomic-scale analysis of microstructures and chemical elements,we discovered that interstitial oxygen atoms enhance LCO and increase local lattice distortion.These heterogeneities increase the formation energy,and localize the diffusion,of vacancies,hence effectively reducing the transport of aggregating helium that causes bubble swelling.The initiation and growth of dislocation loops and precipitates are depressed as well.The manipulation of irradiation defects in BCC MPEAs,through orchestrating interstitial oxygen solutes and the LCO they provoke,adds a practical strategy for designing advanced alloys for nuclear applications. 展开更多
关键词 Multi-principal alloys Local chemical order Radiation defects Interstitial oxygen atoms Transmission electron microscopy
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Interstitial-oxygen-inducedγ-phase precipitation and martensitic transformation behavior in Ni-Mn-Sn-Co alloy prepared through binder jetting and sintering 认领 引用 被引量：1
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作者 Shijiang Zhong Mingfang Qian +5 位作者 Xinxin Shen Shuhe Gong Liangbo Sun Ping Shen Xuexi Zhang Lin Geng 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第11期272-277,共6页
1.Introduction.Ni-Mn-X(X=Ga,In,Sn,or Sb)Heusler alloys have versatile properties[1-4],such as shape memory effect[1],superelastic-ity[5],magnetocaloric effect[3],elastocaloric effect[6],and even multicaloric effect[7]... 1.Introduction.Ni-Mn-X(X=Ga,In,Sn,or Sb)Heusler alloys have versatile properties[1-4],such as shape memory effect[1],superelastic-ity[5],magnetocaloric effect[3],elastocaloric effect[6],and even multicaloric effect[7],that indicate their potential for use in actu-ators,sensors,micropumps,energy harvesters,and solid-state re-frigeration[8-10].Among the alloys,Ni-Mn-Sn-based alloys are environment-friendly and cost-effective[6,7,11],and hence,they have received widespread attention. 展开更多
关键词 phase precipitation martensitic transformation sintering Ni Mn Sn Co alloy shape memory effect superelastic ity magnetocaloric effect elastocaloric effect interstitial oxygen binder jetting multicaloric effect
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Leading role of satellite interstitial electrons in superconductivity in ternary superlithide Li14CP 认领 引用 被引量：1
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作者 Yan Liu Tian Cui Da Li 《Matter and Radiation at Extremes》 SCIE EI CAS CSCD 2025年第2期90-98,共9页
The discovery of pressure-induced superconducting electrides has sparked a intense wave of interest in novel superconductors.However,opinions vary regarding the relationship between non-nuclear attractors(NNAs)and sup... The discovery of pressure-induced superconducting electrides has sparked a intense wave of interest in novel superconductors.However,opinions vary regarding the relationship between non-nuclear attractors(NNAs)and superconductivity,with two opposing views currently represented by the materials Li6P and Li6C.Here,we choose the ternary Li–C–P as a model system and reveal the underlying mechanism by which NNAs contribute to superconductivity.The loosely bound NNAs in the superlithide Li14CP covalently bond with Li and form unique satellite interstitial electrons(SIEs)around Li near the Fermi level,dominating the superconductivity.First-principles calculations show that the SIEs progressively increase in number and couple strongly with phonons at high pressure.Moreover,the Fermi surface nesting associated with SIEs induces phonon softening,further enhancing the electron–phonon coupling and giving the superlithide Li14CP a Tcof 10.6 K at 300 GPa.The leading role of SIEs in superconductivity is a general one and is also relevant to the recently predicted Li6P and Li6C.Our work presented here reshapes the understanding of NNA-dominated superconductivity and holds promise for guiding future discoveries and designs of novel high-temperature superconductors. 展开更多
关键词 ternary superlithide Li CP model system satellite interstitial electrons non nuclear attractors Fermi surface nesting high pressure superconductivity ternary li c p superconductivity
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Microstructural evolution and magnetocaloric properties of off-stoichiometric La1.2Fe11.6Si1.4alloys with interstitial C atoms 认领 引用
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作者 Huiyan Zhang Ye Zhu +7 位作者 Fucheng Zhu Yang Xu Yunbo Chen Hailing Li Weihua Gu Zhiyuan Liu Weihuo Li Ailin Xia 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第8期743-751,共9页
This study investigated the effects of interstitial carbon doping on the microstructural and magnetocaloric properties of off-stoichiometric La1.2Fe11.6Si1.4Cx(x=0,0.25,0.5,0.75,1)alloys.The alloys were prepa... This study investigated the effects of interstitial carbon doping on the microstructural and magnetocaloric properties of off-stoichiometric La1.2Fe11.6Si1.4Cx(x=0,0.25,0.5,0.75,1)alloys.The alloys were prepared by melt-spinning following vacuum arc-melting.For the as-prepared and annealed samples,the carbon existed in the La2Fe2Si2C and NaZn13-type La(Fe,Si)13(denoted by 1:13)phases,respectively.During the annealing process,the C atoms inhibited the diffusion reaction and depressed the generation of 1:13 phase,reducing mass fraction of the 1:13 phase in annealed La1.2Fe11.6Si1.4Cx compounds.The introduction of carbon resulted in lattice expansion and increased the Curie temperature(TC)from 192 K to 273 K with x=0.5.The first-order magnetic transition was gradually transformed into the second-order magnetic transition with increasing carbon content,which induced the significant reduction of thermal and magnetic hysteresis,as well as the maximum magnetic entropy change and adiabatic temperature change vary from 18.92 J/(kg·K)to 4.60 J/(kg·K)and from 4.9 K to 2.2 K under an applied field change of 0-2 T.The results demonstrate that interstitial carbon doping is an effective strategy to improve the magnetocaloric performance of La(Fe,Si)13alloys. 展开更多
关键词 interstitial C addition off-stoichiometric La(Fe Si)13alloy magnetocaloric effect magnetic transition
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Mechanism prediction of Astragalus mongholicus Bunge and Angelica sinensis Diels in treating interstitial lung disease based on network pharmacology and molecular docking 认领 引用
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作者 Jun Du Jian Hao Wei Wei 《TMR药理学研究》 2023年4期1-9，共9页
Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational prediction.Methods:We screened the ingredient... Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational prediction.Methods:We screened the ingredients of AM and AS in PubMed,the Web of Science,China National Knowledge Infrastructure(CNKI)Databases,etc.Then obtained the potential effective components.By sharing the same molecular with ILD,we got the possible target genes for ILD treatment and constructed components–targets–disease network with Cytoscape software.The CTD(Comparative Toxicogenomics Database)database was used for GO and KEGG enrichment analysis of these target genes.Results:59 active ingredients that can be druggable were chosen from AM,67 active ingredients were chosen from AS.77 overlapping target genes for AM and ILD and 36 overlapping target genes for AS and ILD were acquired.The hub targets of AM were PTGS2,PTGS1,CDK2,MAOA,ESR1,TOP2A,GSK3B,ESR2,PPARG,NOS2,The hub targets of AS were PTGS2,GABRA1,PTGS1,CHRM1,SLC6A2,ADRA1B,ADRAIA,ADRB2,CHRM3,GABRA2,CHRM2.Quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,and 5-Hydroxycoumarin were the main active ingredients which have more effective targets.Prediction of the protein-protein interaction network showed PTGS2,GSK3B,PPARG,etc.,were the important predicted targets.The enriched KEGG pathways,including the Immune System,Metabolism of lipids and lipoproteins,Cytokine Signaling in the Immune system,Generic Transcription Pathway,The interleukin pathway,Metabolism of proteins,PI3K-Akt signaling pathway,Metabolic pathways,Innate Immune System,Neuroactive ligand-receptor interaction,Metabolism,GPCR downstream signaling,Amine ligand-binding receptors,Class A/1,Calcium signaling pathway.Molecular docking showed that quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,5-Hydroxycoumarin had good binding activities with PTGS2 and GSK3B,which mainly mediated PI3K/Akt and other important signaling pathways in the pathogenesis of ILD.Conclusion:The components in AS and AM share some common targets,such as PTGS2.AM and AS may ameliorate ILD through the PI3K-Akt signaling pathway which is mediated by GSK3B.PTGS2,PPARG may also be vital target genes in the treatment of ILD with AM and AS. 展开更多
关键词 Astragalus mongholicus Bunge Angelica sinensis Diels computational prediction interstitial lung disease PI3K-Akt signaling pathways
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Rapid enrichment and SERS differentiation of various bacteria in skin interstitial fluid by 4-MPBA-AuNPs-functionalized hydrogel microneedles 认领 引用 被引量：1
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作者 Ying Yang Xingyu Wang +8 位作者 Yexin Hu Zhongyao Liu Xiao Ma Feng Feng Feng Zheng Xinlin Guo Wenyuan Liu Wenting Liao Lingfei Han 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第3期564-576,共13页
Bacterial infection is a major threat to global public health,and can cause serious diseases such as bacterial skin infection and foodborne diseases.It is essential to develop a new method to rapidly diagnose clinical... Bacterial infection is a major threat to global public health,and can cause serious diseases such as bacterial skin infection and foodborne diseases.It is essential to develop a new method to rapidly diagnose clinical multiple bacterial infections and monitor food microbial contamination in production sites in real-time.In this work,we developed a 4-mercaptophenylboronic acid gold nanoparticles(4-MPBA-AuNPs)-functionalized hydrogel microneedle(MPBA-H-MN)for bacteria detection in skin interstitial fluid.MPBA-H-MN could conveniently capture and enrich a variety of bacteria within 5 min.Surface enhanced Raman spectroscopy(SERS)detection was then performed and combined with machine learning technology to distinguish and identify a variety of bacteria.Overall,the capture efficiency of this method exceeded 50%.In the concentration range of 1×107 to 1×1010 colony-forming units/mL(CFU/mL),the corresponding SERS intensity showed a certain linear relationship with the bacterial concentration.Using random forest(RF)-based machine learning,bacteria were effectively distinguished with an accuracy of 97.87%.In addition,the harmless disposal of used MNs by photothermal ablation was convenient,environmentally friendly,and inexpensive.This technique provided a potential method for rapid and real-time diagnosis of multiple clinical bacterial infections and for monitoring microbial contamination of food in production sites. 展开更多
关键词 Hydrogel microneedle SERS Broad-spectrum bacteria detection Skin interstitial fluid Machine learning
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Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis 认领 引用 被引量：1
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作者 Jacob Sutton Georges Khattar +10 位作者 Fares Saliba Omar Mourad Laurence Aoun Jennifer Jdaidani HamzaQandil Chris Kaspar Saif Abu-Baker Shaza Almardini Fadi Haddadin Elie Bou Sanayeh Anastasia Slobodnick 《World Journal of Clinical Cases》 2025年第33期33-43,共11页
BACKGROUND This study investigates the impact of type 2 diabetes mellitus(T2DM)on the risk of interstitial lung disease(ILD)and its subtypes in patients with rheumatoid arthritis(RA).RA is often complicated by ILD.T2D... BACKGROUND This study investigates the impact of type 2 diabetes mellitus(T2DM)on the risk of interstitial lung disease(ILD)and its subtypes in patients with rheumatoid arthritis(RA).RA is often complicated by ILD.T2DM has systemic proinflam-matory effects,but its impact on RA-related ILD is unclear.This research aims to elucidate the interplay between these conditions to inform clinical management and patient care strategies.AIM To determine if RA patients with T2DM have a higher occurrence of ILD compar-ed to RA patients without T2DM.METHODS We conducted a retrospective cohort study using the 2019-2020 National Inpa-tient Sample.Adult RA patients with and without T2DM were identified via International Classification of Diseases,10th Revision(ICD-10)codes.Propensity score matching(1:1)balanced 15+confounders.Logistic regression assessed the association of T2DM with ILD(overall and by subtype)and secondary outcomes(acute respiratory distress syndrome,pneumothorax,pleural effusion,pulmonary hypertension).Missing data were excluded.ILD subtypes were included based on ICD-10 codes and case count.RESULTS Among 199380 RA inpatients,ILD was more common in those with T2DM(2.25%)vs without(1.11%).After matching(n=121046),ILD remained higher in RA+T2DM[odds ratio(OR)=2.02,95%CI:1.84-2.22,P<0.001],with an absolute risk increase of about 1.14%.T2DM was associated with higher odds of ILD subtypes including usual interstitial pneumonia(OR=3.20)and non-specific interstitial pneumonia(OR=3.50).Other subtypes showed elevated ORs;eosinophilic pneumonia showed an inverse association(OR=0.23).PAH and pneumo-thorax were also more common in RA+T2DM(OR=1.40 and 1.85,respectively).Acute respiratory distress syn-drome and pleural effusion rates did not differ by T2DM status.Rare subtype findings should be interpreted cautiously.CONCLUSION T2DM increases ILD risk in RA and is linked to higher rates of pulmonary hypertension and pneumothorax,suggesting a role in exacerbating RA-related lung complications. 展开更多
关键词 Rheumatoid arthritis Diabetes mellitus Interstitial lung disease Pulmonary hypertension Pulmonary fibrosis
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Furmonertinib re-challenge for epidermal growth factor receptormutant lung adenocarcinoma after osimertinib-induced interstitial lung disease:A case report 认领 引用 被引量：2
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作者 Fei-Fei Wei Jing Zhang +2 位作者 Zhe Jia Zhi-Chao Yao Chun-Qiao Chen 《World Journal of Clinical Oncology》 2025年第3期142-150,共9页
BACKGROUND Most non-small cell lung cancer patients have epidermal growth factor receptor(EGFR)activating mutations,such as exon 19 deletion and exon 21 replacement mutations.Osimertinib is a third-generation EGFR-tyr... BACKGROUND Most non-small cell lung cancer patients have epidermal growth factor receptor(EGFR)activating mutations,such as exon 19 deletion and exon 21 replacement mutations.Osimertinib is a third-generation EGFR-tyrosine kinase inhibitors ap-proved for the treatment of lung cancer patients carrying EGFR activating mu-tations.Osimertinib-induced interstitial lung disease(ILD)is a rare and poten-tially fatal pulmonary toxic manifestation of drug therapy.At present,there is no international consensus on the risks and treatment of the osimertinib-induced ILD.CASE SUMMARY We report a case of a 56-year-old woman who was diagnosed with lung adenocar-cinoma with lung hilum,mediastinal lymph nodes and brain metastases(T4N3-M1c stage IVB).The patient received targeted treatment with osimertinib after radiotherapy and chemotherapy.But she developed ILD after osimertinib treat-ment.Following active symptomatic treatment and hormone treatment,the lung injury alleviated.The patient was retreated with furmonertinib combined with prednisone and did not experience ILD again.So far,she has survived for 14 months without disease progression.CONCLUSION Retreatment with furmonertinib under prednisone could be considered as an effective therapeutic option after risk-benefit assessment for EGFR-mutant lung adenocarcinoma patients. 展开更多
关键词 Furmonertinib Osimertinib Lung adenocarcinoma Interstitial lung disease Case report
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The predictive value of NLR and SII in anti⁃MDA5 antibody⁃positive dermatomyositis with rapidly progressive interstitial lung disease 认领 引用 被引量：1
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作者 CAI Qingqing YOU Hanxiao +7 位作者 WANG Lei LÜChengyin SHI Yumeng QIU Yulu WU Lingyun WANG Fang ZHANG Miaojia TAN Wenfeng 《南京医科大学学报（自然科学版）》 CAS 北大核心 2025年第2期196-207,共12页
Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(... Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(anti⁃MDA5+)dermatomyositis(DM)develop into the rapidly progressive interstitial lung disease(RPILD).Methods:We retrospectively analyzed the clinical and laboratory data of 124 anti⁃MDA5+DM patients from the First Affiliated Hospital of Nanjing Medical University between March 2019 and September 2023.We identified independent risk factors associated with the development and mortality of RPILD with the Cox regression analysis,and determined the optimal cut⁃off values for predicting adverse outcomes with the receiver operating characteristic(ROC)curve analysis.Results:Among the 124 patients,36 patients(29.03%)developed RPILD,and 39 patients(31.45%)died during the follow⁃up period.The results of multivariate Cox regression analysis showed that the elevated NLR was an independent risk factor for RPILD development,while the elevated SII expression was independently associated with the increased mortality of RPILD.Based on the ROC curve analysis,NLR>6.12 was a predictor for RPILD,and SII>875.79 was associated with increased mortality risk of RPILD.Conclusion:Both NLR and SII are accessible,cost⁃effective,and reliable prognostic indicators for the prognosis of patients with anti⁃MDA5+DM,providing a valuable guidance for clinical management and risk stratification of the disease. 展开更多
关键词 anti⁃melanoma differentiation⁃associated gene 5⁃positive dermatomyositis neutrophil⁃to⁃lymphocyte ratio rapidly pro⁃gressive interstitial lung disease systemic immune⁃inflammation index
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Anion-modulated HER and OER activity of 1D Co-Mo based interstitial compound heterojunctions for the effective overall water splitting 认领 引用
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作者 Gen Zhang Ying Gu +4 位作者 Lin Li Fuli Ma Dan Yue Xiaoguang Zhou Chungui Tian 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第7期587-592,共6页
The development of highly active and easily coupled non-noble metal electrocatalysts for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is of great significance for the H2 production by water ele... The development of highly active and easily coupled non-noble metal electrocatalysts for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is of great significance for the H2 production by water electrolysis.Here,we have shown an anion-modulated HER and OER activity of 1D Co-Mo based interstitial compound heterojunctions for effective overall water splitting.The Co-Mo based complex nanowires from a one-pot route with high yields can be converted into MoC-Co heterojunction nanowires under N2 atmosphere,while a pyrolysis under NH3 can give CoMoN-CoN heterostructures.The work function revealed Mott-Schottky effect between interfaces of two heterostructures,which can introduce electron redistribution and thus promote the HER/OER process.The MoC-Co heterojunction nanowires delivers good HER activity at a low overpotential of 39mV to afford a current density of 10mA/cm2.Density functional theory calculations show that the heterogeneous interface formed between the Co and MoC optimizes the hydrogen adsorption free energy.Concurrently,CoMoN-CoN heterojunction nanowires exhibits good OER performance with a low overpotential of 260mV to reach 10mA/cm2,being superior to RuO2.The two catalysts can be coupled to assemble a two-electrode cell with a solarto-hydrogen efficiency of 12.3%at 1.54 V.This work provides an effective means to design easily coupled HER and OER catalysts for H2 production by water electrolysis. 展开更多
关键词 Anion-modulated Hydrogen evolution reaction Oxygen evolution reaction Transition metal interstitial compounds Overall water splitting
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Improving kinetic modelling of magnesium hydrogenation by including interfacial polarisation and interstitial hydrogen clustering behaviour within the site availability model 认领 引用
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作者 Marcus J.Adams Alastair Stuart +1 位作者 Gavin S.Walker David M.Grant 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2025年第5期2009-2022,共14页
Recent work analysing magnesium hydrogenation using Reflecting Electron Energy Loss Spectroscopy(REELS)and Density Function Theory(DFT)has indicated interfacial polarisation and interstitial hydrogen clustering influe... Recent work analysing magnesium hydrogenation using Reflecting Electron Energy Loss Spectroscopy(REELS)and Density Function Theory(DFT)has indicated interfacial polarisation and interstitial hydrogen clustering influence the reaction rate.The site availability model has been modified to include interstitial hydrogen clustering within the site availability factor and interface polarisation using interface treatment.The new model,SAM-CV-S,has demonstrated improved modelling of magnesium hydrogenation across wide operating conditions,such as temperatures from 330 to 400℃and pressures up to 40 bar.This wide applicability makes it a robust model that can be used to simulate bed performance in solid-state hydrogen stores.Thus,the site availability factor successfully combines interstitial hydrogen clustering with thermal resistance effects,which are known to strongly influence metal hydride reactor designs at scale.The next phase of the model is to incorporate a predictive hydrogen capacity method into the model. 展开更多
关键词 Magnesium hydrogenation kinetics Site availability factor Interstitial hydrogen clustering Interfacial polarisation
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Therapeutic Effects of Qifangfeixian Granules on Pulmonary Fibrosis in Patients with Interstitial Lung Disease 认领 引用
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作者 Lu-qin Yang Hui-lan Zhang Yong-hao Li 《Current Medical Science》 SCIE CAS CSCD 2025年第5期1079-1086,共8页
Objective To investigate the curative effect of the Qifangfeixian granule on interstitial lung disease(ILD).Methods This study combined animal experiments and clinical trials.Pathological changes in bleomycin(BLM)-ind... Objective To investigate the curative effect of the Qifangfeixian granule on interstitial lung disease(ILD).Methods This study combined animal experiments and clinical trials.Pathological changes in bleomycin(BLM)-induced pulmonary fibrosis in mice were assessed using hematoxylin and eosin(H&E),Masson,and Sirius Red staining.In the clinical study,40 ILD patients were enrolled,with 20 in the control group and 20 in the treatment group.The treatment group received Qifangfeixian granules in addition to standard therapy for 12 weeks.Pulmonary function parameters,including forced vital capacity(FVC,L),FVCpred%,diffusing capacity for carbon monoxide(DLCO,mmol/min/kPa),and DLCOpred%,were measured before and after treatment.Results Compared with those of the control group,the inflammatory infiltration and collagen fibres in the BLM group were significantly increased,and the inflammatory infiltration and collagen fibres in the BLM group were significantly reduced after Qifangfeixian granule treatment.Compared with those in the control group,the lung function parameters in the treatment group were significantly improved.Specifically,the FVC increased by+0.10±0.18 L in the treatment group,whereas the control group showed a decrease of–0.05±0.21 L(P=0.008).Additionally,FVCpred%was improved significantly in the treatment group(+2.6%±5.3%)compared with the control group(–2.0%±6.7%,P=0.009).Conclusion Qifangfeixian granules can improve not only the pulmonary fibrosis of BLM-induced model mice but also the pulmonary function of patients with ILD in practice,and their clinical efficacy is accurate. 展开更多
关键词 Qifangfeixian granule Traditional Chinese Medicine Bleomycin Interstitial lung diseases Pulmonary fibrosis Transforming growth factor beta Smad proteins Pulmonary function test
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