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Isoflavones’effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats 认领 引用 被引量：7
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作者 Ruirui Chang Jialin Liu +5 位作者 Yusha Luo Taohong Huang Qiang Li Jun Wen Weidong Chen Tingting Zhou 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2020年第6期571-580,共10页
Gardeniae Fructus(GF)and Semen Sojae Praeparatum(SSP)are both medicine food homologies and widely used in Chinese clinical prescriptions together.The research investigated the pharmacokinetics of four iridoids in norm... Gardeniae Fructus(GF)and Semen Sojae Praeparatum(SSP)are both medicine food homologies and widely used in Chinese clinical prescriptions together.The research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats,which were administered with isolfavones from SSP for 7,14,21 and 28 consecutive days.A validated LC-MS/MS method was developed for determining shanzhiside,genipin-1-gentiobioside,geniposide and their metabolite genipin in rat plasma.Plasma samples were pretreated by solid-phase extraction using paeoniflorin as the internal standard.The chromatographic separation was performed on a Waters Atlantis T3(4.6 mm×150 mm,3 mm)column using a gradient mobile phase consisting of acetonitril and water(containing 0.06%acetic acid).The mass detection was under the multiple reaction monitoring(MRM)mode via polarity switching between negative and positive ionization modes.The calibration curves exhibited good linearity(r>0.997)for all components.The lower limit of quantitation was in the range of 1 e10 ng/m L.The intra-day and inter-day precisions(RSD)at three different levels were both less than 12.2%and the accuracies(RE)ranged fromà10.1%to 16.4%.The extraction recovery of them ranged from 53.8%to 99.7%.Pharmacokinetic results indicated the bioavailability of three iridoid glycosides and the metabolite,genipin in normal rats was higher than that in rats exposed to isoflavones.With the longer time of administration of isoflavones,plasma concentrations of iridoids decreased,while genipin sulfate,the phase II metabolite of genposide and genipin-1-gentiobioside,appeared the rising exposure.The pharmacokinetic profiles of main iridoids from GF were altered by isoflavones. 展开更多
关键词 Iridoids Gardeniae fructus Isoflavones Rat Pharmacokinetics LC-MS/MS
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Two New Antibacterial Iridoids from Patrinia rupestris 认领 引用 被引量：4
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作者 Xiu Ping YANG Cheng Shan YUAN Zhong Jian JIA 《Chinese Chemical Letters》 SCIE CAS 2006年第3期337-340,共4页
Two new iridoids （1 and 2） were isolated from the roots of Patrinia rupestris （Pail.） Juss. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited strong antibacterial activities ag... Two new iridoids （1 and 2） were isolated from the roots of Patrinia rupestris （Pail.） Juss. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited strong antibacterial activities against Eschecichia coli and Staphylococcus aureus, respectively. 展开更多
关键词 Patrinia rupestris Valerianaceae iridoids antibacterial activity.
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Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert 认领 引用 被引量：12
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作者 NAN Ze-Dong ZHAO Ming-Bo +4 位作者 Zeng Ke-Wu TIAN Shuai-Hua WANG Wei-Nan JIANG Yong TU Peng-Fei 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2016年第1期61-65,共5页
In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert,a systematically phytochemical investigation was carried out.The constituents were isolated by silica gel,Sephadex LH-2... In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert,a systematically phytochemical investigation was carried out.The constituents were isolated by silica gel,Sephadex LH-20,MCI gel,ODS column chromatography,and semi-preparative HPLC.Their structures were determined on the basis of MS and NMR spectroscopic analyses,by chemical methods,and/or comparison with literature data.The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects on the lipopolysaccharide(LPS)-induced nitric oxide(NO)production in BV-2 mouse microglial cells.Nine iridoids were isolated and identified as cistadesertoside A(1),cistanin(2),cistachlorin(3),6-deoxycatalpol(4),gluroside(5),kankanoside A(6),ajugol(7),bartsioside(8),and 8-epi-loganic acid(9).Compound 9 exhibited potent inhibition on the NO production with an IC50 value being 5.2 μmol·L-1,comparable to the positive control quercetin(4.3 μmol·L-1).Compound 1 was a new iridoid,and compounds 5,6,and 8 were isolated from this species for the first time. 展开更多
关键词 Cistanche deserticola Iridoids Structure elucidation Anti—inflammatory activity
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Iridoids modulate inflammation in diabetic kidney disease: A review 认领 引用 被引量：5
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作者 Tong-yi Zhou Na Tian +1 位作者 Liu Li Rong Yu 《Journal of Integrative Medicine》 SCIE CAS CSCD 2024年第3期210-222,共13页
In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical attention.DKD has become a pervasive complication of type 2 diabetes.Given the complexity of... In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical attention.DKD has become a pervasive complication of type 2 diabetes.Given the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achieving desired therapeutic outcomes.Iridoids,primarily derived from the potent components of traditional herbs,have been the subject of long-standing research.Preclinical data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of DKD.This article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this condition.Additionally,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic effects.This review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors. 展开更多
关键词 Diabetic kidney disease Iridoids Gut-kidney axis Traditional Chinese medicine monomer Inflammation
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Cytoprotective effects of iridoids from Gaultheria spp.berries in gastric and intestinal epithelial cells after in vitro digestion 认领 引用
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作者 Luise Amelie Lauer Daniel Mieres-Castro +2 位作者 Victor Schmalle Jan Frank Felipe Jiménez-Aspee 《Food Bioscience》 SCIE 2024年第1期1717-1728,共12页
Reactive oxygen species may induce oxidation of macromolecules in foods and during digestion in the gastrointestinal tract,negatively impacting human health.Antioxidants present in plant foods,including carotenoids,to... Reactive oxygen species may induce oxidation of macromolecules in foods and during digestion in the gastrointestinal tract,negatively impacting human health.Antioxidants present in plant foods,including carotenoids,tocochromanols,ascorbic acid,as well as(poly)phenols and iridoids,may counteract oxidation of macromolecules.The aims of the present study were to determine the contents of carotenoids,tocochromanols,ascorbic acid from Gaultheria spp.berries and to investigate the cytoprotective and antioxidant activities of the fruit extracts and monotropein esters present in the berries.Moreover,the underlying mechanisms of action in gastrointestinal epithelial cells after in vitro digestion was also investigated.The content of ascorbic acid ranged from 3 to 24 mg/100 g fw,carotenoids from 9 to 56μg/100 g fw,and total tocochromanols from 0.29 to 0.45 mg/100 g fw.The pre-incubation of gastric(AGS)and intestinal(Caco-2)cells with Gaultheria fruit extracts significantly increased viability of cells stressed with 10 mM H2 O2 and 100 mM AAPH,respectively,compared to control cells.Furthermore,digested Gaultheria fruit extracts and monotropein esters increased the relative mRNA of the Nrf2/Keap1/ARE antioxidant signaling pathway and enzymes such as superoxide dismutase(SOD),glutathione peroxidase(GPX)and reductase,and catalase(CAT).The pre-incubation of Caco-2 cells with digested monotropein and monotropein esters increased the protein expression of GPX,CAT,Keap1,and Nrf2,and incremented the SOD activity in Caco-2 cells.In conclusion,Gaultheria spp.fruit extracts and monotropein esters may protect gastrointestinal epithelial cells against oxidative stress during digestive processes. 展开更多
关键词 In vitro digestion Tocochromanols Carotenoids Ascorbic acid Iridoids Monotropein Oxidative stress
Discovery of New Iridoids as Farnesoid X Receptor Agonists from Morinda officinalis: Agonistic Potentials and Molecular Stimulation 认领 引用 被引量：1
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作者 Zhi-Lin Luan Fei Qiao +11 位作者 Wen-Yu Zhao Wen-Hua Ming Zhen-Long Yu Jie Liu Sheng-Yun Dai Shuang-Hui Jiang Chao-Jie Lian Cheng-Peng Sun Bao-Jing Zhang Jian Zheng Shuang-Cheng Ma Xiao-Chi Ma 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2021年第5期1288-1296,共9页
The investigation of Morinda officinalis led to the isolation of twelve compounds(1-12),including three new iridoid glycosides morindallns A-C(1-3)and nine known compounds(4-12).Their structural identifications were c... The investigation of Morinda officinalis led to the isolation of twelve compounds(1-12),including three new iridoid glycosides morindallns A-C(1-3)and nine known compounds(4-12).Their structural identifications were conducted using HRMS,1D and 2D NMR,and electronic circular dichroism(ECD)spectra as well as quantum chemical computations.Compound 6 displayed the most significantly agonistic activity against farnesoid X receptor(FXR)with an EC50 value of 7.18 μM,and its agonistic effect was verified through the investigation of FXR downstream target genes including small heterodimer partner 1(SHP1),bile salt export pump(BSEP),and organic solute transporter subunit alpha and beta(OSTα and OSTβ).The potential interaction of compound 6 with FXR was analyzed by molecular docking and molecular dynamics stimulation,revealing that amino acid residues Leu287;Thr288,and Ser332 played a crucial role in the activation of compound 6 towards FXR.These findings suggested that compound 6 could be regarded as a potential candidate for the development of FXR agonists. 展开更多
关键词 Morinda officinalis Iridoid Farnesoid X receptor Agonistic effect
A new iridoid glycoside from Paederia scandens 认领 引用 被引量：5
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作者 He, Da Hai Chen, Jin Song +1 位作者 Wang, Xiao Ling Ding, Ke Yi 《Chinese Chemical Letters》 SCIE CAS 2010年第4期437-439,共3页
A new glycoside named 6β-O-β-D-glucosylpaederosidic acid(1) was isolated from Paederia scandens and its structure was elucidated on the basis of spectroscopic and chemical evidence,together with four known iridoids,... A new glycoside named 6β-O-β-D-glucosylpaederosidic acid(1) was isolated from Paederia scandens and its structure was elucidated on the basis of spectroscopic and chemical evidence,together with four known iridoids,paederoside(2),paederosidic acid(3),paederosidic acid methyl ester(4),and deacetyl asperulosidic acid methyl ester(5).Compound 5 was isolated from this plant for the first time. 展开更多
关键词 Paederia scandens Iridoids Chemical structure 6β-O-β-D-Glucosylpaederosidic acid Deacetyl asperulosidic acid methyl ester
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Effects of Different Compounding of Formulae on Content of Gardenoside in Yin Chen Hao Decoction 认领 引用
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作者 梁光义 曹佩雪 +3 位作者 柴立 冼福荣 李霞 王友京 《Journal of Traditional Chinese Medicine》 2002年第1期55-60,共6页
In order to observe the effects of the ground and intact Zhi Zi (Fructus Gardeniae) and different combinations of the ingredients and refined single Chinese drug granules in Yin Chen Hao Decoction compound prescriptio... In order to observe the effects of the ground and intact Zhi Zi (Fructus Gardeniae) and different combinations of the ingredients and refined single Chinese drug granules in Yin Chen Hao Decoction compound prescription on the contents of gardenoside (an effective component of the prescription), the contents of gardenoside were determined with reversed phase high performance liquid chromatography (HPLC), with acetonitrile-water (15:85) as mobile phase, at wave length 238nm. The results indicated that the gardenoside-decocted-out rates in the decoctions prepared by different combinations of the ingredients with the ground Zhi Zi (Fructus Gardeniae) all were higher significantly than those in the decoction with intact Zhi Zi (Fructus Gardeniae), and generally, different combinations of the ingredients in the decoction had only little effect on the gardenoside-decocted-out rate. 展开更多
关键词 Iridoids Chromatography, High Pressure Liquid Comparative Study Drug Compounding Drugs, Chinese Herbal Pyrans Technology, Pharmaceutical
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Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea 认领 引用 被引量：9
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作者 Yan Bo Zeng Wen Li Mei +3 位作者 You Xing Zhao Ling Zhuang Kui Hong Hao Fu Dai 《Chinese Chemical Letters》 SCIE CAS 2007年第12期1509-1511,共3页
Two new epimeric pairs of iridoid scyphiphin A1 （la）, A2 （lb） and scyphiphin B 1 （2a）, B2 （2b） were isolated from Scyphiphora hydrophyllacea Gaertn. F. Their structures were elucidated by spectroscopic methods... Two new epimeric pairs of iridoid scyphiphin A1 （la）, A2 （lb） and scyphiphin B 1 （2a）, B2 （2b） were isolated from Scyphiphora hydrophyllacea Gaertn. F. Their structures were elucidated by spectroscopic methods. The mixture of scyphiphin B 1 and scyphiphin B2 showed moderate cytotoxicity against human hepatoma SMMC-7721 cell line in vitro by MTT method. 展开更多
关键词 Scyphiphora hydrophyllacea Gaertn. E Iridoid Cytotoxicity SMMC-7721
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The chemical constituents from the roots of Gentiana crassicaulis and their inhibitory effects on inflammatory mediators NO and TNF-α 认领 引用 被引量：13
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作者 Tao LV Min XU +4 位作者 Dong WANG Hong-Tao ZHU Chong-Ren YANG Tian-Tai ZHANG Ying-Jun ZHANG 《Natural Products and Bioprospecting》 2012年第5期217-221,共5页
Chemical study on the roots of Gentiana crassicaulis Duthie ex Burk(Gentianaceae)afforded 15 compounds,including two new iridoid glycosides,qinjiaosides B(1)and C(2).Their structures were elucidated by spectroscopic m... Chemical study on the roots of Gentiana crassicaulis Duthie ex Burk(Gentianaceae)afforded 15 compounds,including two new iridoid glycosides,qinjiaosides B(1)and C(2).Their structures were elucidated by spectroscopic methods and chemical evidence.The isolated iridoid glycosides 1,4-6 and 8-11 were tested for their anti-inflammatory activity by the inhibitory effects on LPS-induced NO and TNF-αproduction in macrophage RAW264.7 cells.All of them showed inhibitory effects on inflammatory mediators NO at a concentration of 15μM,while 5 and 9 displayed the most potential inhibitory effects on TNF-awith IC50 of 0.06 and 0.05μM,respectively.The structure-activity relationships(SARs)of these iridoid derivatives were discussed. 展开更多
关键词 Gentiana crassicaulis Gentianaceae iridoid glycosides qinjiaosides
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A new iridoid glycoside from Gardenia jasminoides 认领 引用 被引量：12
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作者 Xiao Qin Zhou Zhi Ming Bi +2 位作者 Ping Li Dan Tang Hal Xia Cai 《Chinese Chemical Letters》 SCIE CAS 2007年第10期1221-1223,共3页
A new iridoid glycoside, 6＇-O-sinapoylgeniposide, was isolated from Gardeniajasminoides Ellis and its structure was elucidated on the basis of 1D and 2D NMR, HR-ESI-MS techniques.
关键词 Gardenia jasminoides Iridoid glycoside 6＇-O-Sinapoylgeniposide
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Anti-tumor activity of Hedyotis diffusa Willd. in mice 认领 引用 被引量：5
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作者 王英锋 郑宜 +3 位作者 库宝善 姚海燕 姚广印 万阳丽 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2013年第3期272-276,共5页
The whole plant with root ofHedyotis diffusa Willd. （AE） has been demonstrated to have anti-inflammatory, antioxidant, and anti-bacterial activities. In our study, we aim to examine the anti-tumor effect of alcoholi... The whole plant with root ofHedyotis diffusa Willd. （AE） has been demonstrated to have anti-inflammatory, antioxidant, and anti-bacterial activities. In our study, we aim to examine the anti-tumor effect of alcoholic extract of AE in mice implanted with sarcoma S180 cells （SBT mice）. We also compared the immune system function and the life span of SBT mice with that of control mice. We found that AE displayed a significant inhibitory effect on solid tumor growth, as well as increased the life span. At the dose of 10 mg/kg body weight, both tumor weight and volume were decreased significantly. We also measured several immune fimction markers, inlcuding spleen index （SI）, thymus index （TI） and parameters of hematological. We observed no reduce in these markers, indicatine that AE could inhibit tumor ~rowth without affectino immune function in SBT ,nice. 展开更多
关键词 Hedyotis diffusa Willd. Anti-tumor Immunomodu（atory Iridoid E-6-O-p-coumaroyl scandoside methyl ester
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Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction 认领 引用 被引量：3
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作者 Deng-lei MA Yi LUO +6 位作者 Rui HUANG Zi-run ZHAO Li ZhANG Ya-li LI Qi WANG Lin LI Lan ZhANG 《Current Medical Science》 SCIE CAS 2020年第6期1031-1039,共9页
rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer’s disease(AD).Besides cognitive impairments,rTg4510 mice also show abnormal h... rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer’s disease(AD).Besides cognitive impairments,rTg4510 mice also show abnormal hyperactivity behavior.Cornel iridoid glycoside(CIG)is an active ingredient extracted from Cornus officinalis,a traditional Chinese herb.The purpose of the present study was to investigate the effects of CIG on the emotional disorders such as hyperactivity,and related mechanisms.The emotional hyperactivity was detected by locomotor activity test and Y maze test.Immunofluorescent and immunohistochemical analyses were conducted to measure neuron loss and phosphorylated tau.Western blotting was used to detect the expression of related proteins.The results showed that intragastric administration of CIG for 3 months decreased the hyperactivity phenotype,prevented neuronal loss,reduced tau hyperphosphorylation and aggregation in the amygdala of rTg4510 mice.Meanwhile,CIG alleviated the synaptic dysfunction by increasing the expression of N-methyl-D-aspartate receptors(NMDARs)subunits GluN1 and GluN2A andαamino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)subunits GluA1 and GluA2,and increased the level of phosphorylated Ca2+/calmodulin dependent protein kinase IIα(p-CaMK IIα)in the brain of rTg4510 mice.In conclusion,CIG may have potential to treat the emotional disorders in tauopathies such as AD through reducing tau pathology and improving synaptic dysfunction. 展开更多
关键词 cornel iridoid glycoside rTg4510 mouse hyperactivity tauopathy Alzheimer’s disease tau phosphorylation synaptic function
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A new iridoid glycoside from Veronica sibirica 认领 引用 被引量：3
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作者 Jie Teng Fu Geng Zhang +2 位作者 Yan Wen Zhang Yoshihisa Takaishi Hong Quan Duan 《Chinese Chemical Letters》 SCIE CAS 2008年第4期450-452,共3页
A new iridoid glycoside,versibirioside（1）,and a known iridoid glycoside,verbaspinoside（2）,were isolated from the whole plant of Veronica sibirica L.Their structures were elucidated by spectroscopic methods,includi... A new iridoid glycoside,versibirioside（1）,and a known iridoid glycoside,verbaspinoside（2）,were isolated from the whole plant of Veronica sibirica L.Their structures were elucidated by spectroscopic methods,including 2D-NMR spectra. 展开更多
关键词 Veronica sibirica L. Versibirioside Iridoid glycoside
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A New Iridoid Glucoside from Lagotis yunnanensis 认领 引用 被引量：3
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作者 XiaoDongYANG ShuangXiMEI +3 位作者 JingFengZHAO GanPengLI HongBinZHANG LiangLI 《Chinese Chemical Letters》 SCIE CAS 2003年第9期936-938,共3页
Phytochemical investigation of Lagotis yunnanensis led to the isolation and identification of a new iridoid glucoside 1, named as 10-O-(3,4-dimethoxy-(E)-cinnamoyl)aucubin. Its structure was elucidated by spectroscopi... Phytochemical investigation of Lagotis yunnanensis led to the isolation and identification of a new iridoid glucoside 1, named as 10-O-(3,4-dimethoxy-(E)-cinnamoyl)aucubin. Its structure was elucidated by spectroscopie methods. 展开更多
关键词 Lagotis yunnanensis iridoid glucoside 10-O-(3 4-dimethoxy-(E)-cinnamoyl)aucubin.
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Two New Iridoid Glucosides from Clerodendrum serratum 认领 引用 被引量：2
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作者 Hui YANG Bei JIANG +2 位作者 Zhi NA Yun Pin GUO Han Dong SUN 《Chinese Chemical Letters》 SCIE CAS 2000年第3期231-234,共4页
Two new iridoid glucosides, serratoside A and serratoside B, were isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Their structures were elucidated by spectral and chemical methods.
关键词 Clerodendrum serratum Verbenaceae iridoid glucoside serratoside A serratoside B
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A New Secoiridoidal Glucoside from Gentiana rigescens(Gentianaceae) 认领 引用 被引量：19
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作者 XU Min WANG Dong +1 位作者 ZHANG Ying-Jun YAN Chong-Ren 《云南植物研究》 北大核心 2006年第6期669-672,共4页
A new acylated secoiridoidal glucoside,named gentiorigenoside A(1),was isolated from the root of Centiarm rigescens(Gentianaceae),together with eight known compounds,gentiopicroside(2),6'-O-β-D-glucopyranosyl gen... A new acylated secoiridoidal glucoside,named gentiorigenoside A(1),was isolated from the root of Centiarm rigescens(Gentianaceae),together with eight known compounds,gentiopicroside(2),6'-O-β-D-glucopyranosyl gentiopicroside(3),loganic acid(4),6'-O-β-D-glucopyranosyl loganic acid(5),sweroside(6),2'-(o,m-dihydoxybenzyl)-sweroside(7),swertiamarin(8)and secologanoside(9).heir structures were elucidated on the basis of detailed spectroscopic analysis.Iridoidal glucosides 3,5 and 9 were isolated for the first time from the title plant. 展开更多
关键词 Centiana rigescens Iridoidal glucosides Gentiorigenoside A
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Comparative Study on“Long-Dan”,“Qin-Jiao”and Their Adulterants by HPLC Analysis 认领 引用 被引量：2
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作者 Fang-Fang Liu Yan-Ming Wang +4 位作者 Hong-Tao Zhu Dong Wang Chong-Ren Yang Min Xu Ying-Jun Zhang 《Natural Products and Bioprospecting》 2014年第5期297-308,共12页
“Long-Dan”and“Qin-Jiao”are two important TCM herbs since ancient times in China.In the Chinese Pharmacopoeia,the dried roots and rhizomes of four species from the genus Gentiana,e.g.Gentiana manshurica,G.scabra,G.... “Long-Dan”and“Qin-Jiao”are two important TCM herbs since ancient times in China.In the Chinese Pharmacopoeia,the dried roots and rhizomes of four species from the genus Gentiana,e.g.Gentiana manshurica,G.scabra,G.triflora and G.rigescens,are recorded under the name of Gentianae Radix et Rhizoma(“Long-Dan”in Chinese),while the other four species from the same genus including G.macrophylla,G.crassicaulis,G.straminea and G.duhurica are recorded and used as the raw materials of Gentianae Macrophyllae Radix(“Qin-Jiao”in Chinese).On the basis of the establishment of a validated HPLC–UV method for quantifying simultaneously,five iridoid glycosides,e.g.loganic acid(1),swertiamarinin(2),gentiopicroside(3),sweroside(4)and 20-(o,m-dihydroxybenzyl)sweroside(5)have been used successfully as chemical markers for the comparison of the species used as“Long-Dan”,“Qin-Jiao”and their adulterants in the present study.The results suggested that four iridoid glycosides 1–4 commonly existed in both“Long-Dan”and“Qin-Jiao”,while 20-(o,m-dihydroxybenzyl)sweroside(5)also existed as one of the major components in“Dian-Long-Dan”species.Moreover,the contents of compounds 1–5 were various in different“LongDan”and“Qin-Jiao”species.Herein,we profiled and compared three“Long-Dan”species,four“Qin-Jiao”species and five adulterants by applying multivariate statistical techniques to their HPLC data sets to establish the differences and/or similarities. 展开更多
关键词 “Long-Dan” “Qin-Jiao” Gentiana HPLC analysis Iridoid glycosides
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Two New Iridoid Glucosides from Clerodendrum serratum 认领 引用 被引量：2
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作者 Xiao Mei WEI Qi Xiou ZHU +1 位作者 Jin Chun CHEN Dong Liang CHENG 《Chinese Chemical Letters》 SCIE CAS 2000年第5期415-416,共2页
Two new iridoid glucosides, named 7 beta -coumaroyloxyugandoside (1) and 7 beta - cinnamoyloxyugandoside (2) were isolated from the leaves of Clerodendrum serratum, and their structures were elucidated by spectral means.
关键词 Clerodendrum serratum Verbenaceae iridoid glucoside 7 beta-coumaroyloxyugandoside (1). 7 beta-cinnamoyloxyugandoside (2).
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Non-alkaloid constituents of Vinca major 认领 引用 被引量：1
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作者 CHENG Gui-Guang ZHAO Hai-Yun +6 位作者 LIU Lu ZHAO Yun-Li SONG Chang-Wei GU Ji SUN Wei-Bang LIU Ya-Ping LUO Xiao-Dong 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2016年第1期56-60,共5页
The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The... The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside （compound 1）, together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2μmaol·L 1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity. 展开更多
关键词 Vinca major Iridoid glycoside Vinmaside A Antioxidant
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