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Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes 认领 引用
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作者 An-Ran Wang Yu-Yang Zhang +4 位作者 Yi-Jun Liu Li-Nan Ren Qi-Hui Yan Kai-Fang Wang Yan Wang 《World Journal of Stem Cells》 SCIE 2026年第3期116-130,共15页
BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.Although globular adiponectin(gAd)shows potential in improving islet function,its clinical application is limited by rapid clearance.Give... BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.Although globular adiponectin(gAd)shows potential in improving islet function,its clinical application is limited by rapid clearance.Given the promising prospects of adipose-derived mesenchymal stem cell exosomes(Exos)in targeted therapy,whether this nanocarrier can enhance gAd’s efficacy in improving islet function warrants significant research attention.AIM To develop a new synergistic therapeutic strategy based on adipose-derived mesenchymal stem cells Exos loaded with gAd(gAd-Exo).METHODS A T2DM rat model was established using a high-fat diet and streptozotocin.Rats were randomized into control,T2DM,T2DM+gAd,T2DM+Exo,and T2DM+gAd-Exo groups,receiving respective treatments via tail vein injection for four weeks.Pancreatic tissues were subjected to histological,immunohistochemical,and biochemical analyses.Meanwhile in vitro experiments assessed the protective effects of gAd-Exo on palmitic acid-injured INS-1 cells.RESULTS gAd-Exo treatment significantly ameliorated hyperglycemia,improved pancreatic islet morphology,and reducedβ-cell apoptosis compared to other groups.It enhanced insulin sensitivity and down-regulated glucagon expression.Mechanistically,gAd-Exo activated the AMP-activated protein kinase/acetyl-CoA carboxylase signaling pathway.In vitro,gAd-Exo superiorly mitigated palmitic acid-induced oxidative stress and apoptosis in INS-1 cells.CONCLUSION This study shows that the combination of gAd and Exo produced a significant synergistic effect.gAd-Exo can relieve type 2 diabetes by reducing blood glucose,improving hyperinsulinaemia and islet function,and at the same time reducing isletβcells apoptosis.It may be achieved by activating the AMP-activated protein kinase/acetyl-CoA carboxylase pathway.The discovery provides a new strategy with synergistic regenerative potential for diabetes treatment. 展开更多
关键词 Adipose-derived mesenchymal stem cells Exosomes Type 2 diabetes mellitus Insulin sensitivity Islet function
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Effect of Renin Angiotensin System Blockade on the Islet Microvessel Density of Diabetic Rats and Its Relationship with Islet Function 认领 引用 被引量：1
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作者 李新 袁莉 +4 位作者 徐国玲 齐翠娟 李进 李海玲 程梭梭 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2009年第6期684-688,共5页
To investigate the effects of rennin angiotensin system blockade on the microvessel density in islets of diabetic rats and its relationship with islet function, diabetes model was created by feeding of high-caloric la... To investigate the effects of rennin angiotensin system blockade on the microvessel density in islets of diabetic rats and its relationship with islet function, diabetes model was created by feeding of high-caloric laboratory chow plus intraperitoneal injection of a small dose of streptozotocin （30 mg/kg）. After 8 weeks intervention with perindopril （AE, n=10） or valsartan （AR, n=10）, the islet function of the animals was evaluated by intravenous insulin release test （IVIRT）. The pancreases were immunohistochemically stained to analyze the content of insulin and vascular endothelial growth factor （VEGF） in the islets. The microvessel density （MVD） of islets was detected by counting CD34 positive cells. The hypoxia inducible factor （HIF）-1α mRNA expression in the islets was detected by RT-PCR. Compared with normal control group （NC, n=10）, the area under the curve for insulin from 0 to 30 min （AUCI0-30） of diabetes group （DM, n=8） was decreased by 66.3%; the insulin relative concentration （IRC） of βcell was decreased significantly; the relative content of VEGF was increased obviously [（–4.21±0.13） vs （–4.06±0.29）]; MVD in islets was decreased by 71.4%; the relative expression of HIF-1α mRNA was increased by 1.19 times （all P〈0.01）. Compared with DM group, the AUCI0-30 of AE and AR group was increased by 44.6% and 34.9% respectively; IRC was also increased significantly; the relative content of VEGF was decreased by 21.2% and 21.7% respectively; MVD was increased by 62.5% and 75.0% respectively; the relative expression of HIF-1α was decreased by 27.2% and 29.0% respectively （all P〈0.01 or P〈0.05）. There were no significant differences in the said indexes between group AE and AR. It is concluded that the blockade of RAS may ameliorate islets function of diabetic rats by increasing the MVD in islets. 展开更多
关键词 renin angitotensin system diabetes mellitus islet function microvessel density
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A Study on Enhancing Pancreatic Islet Function in Type 2 Diabetes and Coronary Heart Disease Patients with Liraglutide and Metformin Combination Therapy 认领 引用 被引量：2
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作者 Chunxiao Yang 《Proceedings of Anticancer Research》 2023年第6期116-121,共6页
Objective:To investigate the impact of combining liraglutide with metformin on the enhancement of pancreatic islet function in patients with type 2 diabetes and coronary heart disease.Methods:60 patients with type 2 d... Objective:To investigate the impact of combining liraglutide with metformin on the enhancement of pancreatic islet function in patients with type 2 diabetes and coronary heart disease.Methods:60 patients with type 2 diabetes and coronary heart disease admitted from February 2022 to August 2023 were selected as research subjects.They were randomly assigned to either control or treatment groups,with 30 patients in each.The control group received metformin alone,while the treatment group received liraglutide in combination with metformin.Various indicators,including blood sugar levels,pancreatic islet function,and cardiac function between the two groups were compared.Results:The results of FPG,2hPG,HbA1c,HOMA-IR,NT-proBNP,and LVEDD in the treatment group were lower than those in the control group,whereas the values of FINS,HOMA-β,E/A,and LVEF in the treatment group were higher than those in the control group(P<0.05).Conclusion:The use of liraglutide in combination with metformin significantly benefits patients with type 2 diabetes and coronary heart disease.It leads to improved pancreatic islet function,better blood sugar control,and enhanced cardiac function.This combination therapy is recommended for clinical adoption. 展开更多
关键词 Liraglutide Metformin Type 2 diabetes Coronary heart disease Pancreatic islet function
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Influence of heme oxygenase-1 gene transfer on the viability and function of rat islets in in vitro culture 认领 引用 被引量：6
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作者 Xiao-Bo Chen Yong-Xiang Li +4 位作者 Yang Jiao Wei-Ping Dong Ge Li Jing Chen Jian-Ming Tan 《World Journal of Gastroenterology》 SCIE CAS 2007年第7期1053-1059,共7页
AIM. To investigate the influence of heme oxygenase-1 （HO-1） gene transfer on the viability and function of cultured rat islets in vitro. METHODS： Islets were isolated from the pancreata of Sprague-Dawley rats by i... AIM. To investigate the influence of heme oxygenase-1 （HO-1） gene transfer on the viability and function of cultured rat islets in vitro. METHODS： Islets were isolated from the pancreata of Sprague-Dawley rats by intraductal collagenase digestion, and purified by discontinuous Ficoll density gradient centrifugation. Purified rat islets were transfected with adenoviral vectors containing human HO-1 gene （Ad- HO-1） or enhanced green fluorescent protein gene （Ad- EGFP）, and then cultured for seven days. Transfection was confirmed by fluorescence microscopy and Western blot. Islet viability was evaluated by acridine orange/ propidium iodide fluorescent staining. Glucose-stimulated insulin release was detected using insulin radioimmunoassay kits and was used to assess the function of islets. Stimulation index （SI） was calculated by dividing the insulin release upon high glucose stimulation by the insulin release upon low glucose stimulation. RESULTS： After seven days culture, the viability of cultured rat islets decreased significantly （92% ± 6% vs 52% ± 13%, P 〈 0.05）, and glucose-stimulated insulin release also decreased significantly （6.47 ± 0.55 mIU/ L/30IEO vs 4.57 ± 0.40 mIU/L/3OIEO., 14.93 ± 1.17 mIU/L/30IEQ vs 9.63 ± 0.71 mIU/L/30IEQ, P 〈 0.05）. Transfection of rat islets with adenoviral vectors at an 1±10 of 20 was efficient, and did not impair islet function. At 7 d post-transfection, the viability of Ad-HO-1 transfected islets was higher than that of control islets（71% ± 15% vs 52% ± 13%, P 〈 0.05）. There was no significant difference in insulin release upon low glucose stimulation （2.8 mmol/L） among Ad-HO-1 transfected group, Ad-EGFP transfected group, and control group （P 〉 0.05）, while when stimulated by high glucose （16.7 mmol/L） solution, insulin release in Ad-HO-1 transfected group was significantly higher than that in Ad-EGFP transfected group and control group, respectively （12.50 ±2.17 mIU/L/30IEQ vs 8.87 ± 0.65 mIU/L/30IEQ, 12.50 ± 2.17 mIU/L/30IEQ vs 9.63 ± 0.71 mIU/L/30IEQ, P 〈 0.05）. The SI of Ad-HO-1 transfected group was also significantly higher than that of Ad-EGFP transfected group and control group, respectively （2.21 ± 0.02 vs 2.08 ± 0.05; 2.21 ± 0.02 vs 2.11 ± 0.03, P 〈 0.05）. CONCLUSION： The viability and function of rat islets decrease over time in in vitro culture, and heine oxygenase-1 gene transfer could improve the viability and function of cultured rat islets. 展开更多
关键词 Islet viability, Islet function Heineoxygenase-1 Gene transfer, Adenoviral vectors
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Small intestinal submucosa improves islet survival and function during in vitro culture 认领 引用 被引量：3
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作者 Xiao-Hui Tian Wu-Jun Xue Xiao-Ming Ding Xin-Lu Pang Yan Teng Pu-Xun Tian Xin-Shun Feng 《World Journal of Gastroenterology》 SCIE CAS 2005年第46期7378-7383,共6页
AIM： To evaluate the recovery and function of isolated rat pancreatic islets during in vitro culture with small intestinal submucosa （SIS）. METHODS： Pancreatic islets were isolated from Wistar rats by standard sur... AIM： To evaluate the recovery and function of isolated rat pancreatic islets during in vitro culture with small intestinal submucosa （SIS）. METHODS： Pancreatic islets were isolated from Wistar rats by standard surgical procurement followed by intraductal collagenase distension, mechanical dissociation and Euroficoll purification. Purified islets were cultured in plates coated with multilayer SIS （SIS-treated group） or without multilayer SIS （standard cultured group） for 7 and 14 d in standard islet culture media of RPMI 1640. After isolation and culture, islets from both experimental groups were stained with dithizone and counted. Recovery of islets was determined by the ratio of counts after the culture to the yield of islets immediately following islet isolation. Viability of islets after the culture was assessed by the glucose challenge best with low （2.7 mmol/L） and high glucose （16.7 mmol/L） solution supplemented with 50 mmol/L 3-isobutyl-1- methylxanthine （IBMX） solution. Apoptosis of islet cells after the culture was measured by relative quantification of histone-complexed DNA fragments using ELISA. RESULTS： After 7 or 14 d of in vitro tissue culture, the recovery of islets in SIS-treated group was significantly higher than that cultured in plates without SIS coating. The recovery of islets in SIS-treated group was about twice more than that of in the control group. In SIS treated group, there was no significant difference in the recovery of islets between short- and long-term periods of culture （95.8±1.0% vs 90.8±1.5%, P〉0.05）. When incubated with high glucose （16.7 mmol/L） solution, insulin secretion in SIS-treated group showed a higher increase than that in control group after 14 d of culture （20.7±1.1 mU/L vs 11.8±1.1 mU/L, P〈0.05）. When islets were placed in high glucose solution containing IBMX, stimulated insulin secretion was higher in SlS-treated group than in control group. Calculated stimulation index of SlS-treated group was about 23 times of control group. In addition, the stimulation index of SlS-treated group remained constant regardless of short- and long- term periods of culture （9.5±0.2 vs 10.2±1.2, P〉0.05）. Much less apoptosis of islet cells occurred in SlS-treated group than in control group after the culture. CONCLUSION： Co-culture of isolated rat islets with native sheet-like SIS might build an extracellular matrix for islets and provide possible biotrophic and growth factors that promote the recovery and subsequent function of islets. 展开更多
关键词 Islet culture Islet survival Islet function Small intestinal submucosa
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Relationship between Free Thyroxine and Islet Beta-cell Function in Euthyroid Subjects 认领 引用 被引量：8
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作者 Qing LI Meng LU +9 位作者 Ning-jian WANG Yi CHEN Ying-chao CHEN Bing HAN Qin LI Fang-zhen XIA Bo-ren JIANG Hua-ling ZHAI Dong-ping LIN Ying-li LU 《Current Medical Science》 SCIE CAS 2020年第1期69-77,共9页
Thyroid hormones have a specific effect on glucose-induced insulin secretion from the pancreas.We aimed to investigate the association between euthyroid hormones and islet betacell function in general population and n... Thyroid hormones have a specific effect on glucose-induced insulin secretion from the pancreas.We aimed to investigate the association between euthyroid hormones and islet betacell function in general population and non-treated type 2 diabetes mellitus(T2DM)patients.A total of 5089 euthyroid participants(including 4601 general population and 488 non-treated T2DM patients)were identified from a cross-sectional survey on the prevalence of metabolic diseases and risk factors in East China from February 2014 to June 2016.Anthropometric indices,biochemical parameters,and thyroid hormones were measured.Compared with general population,non-treated T2DM patients exhibited higher total thyroxine(TT4)and free thyroxine(FT4)levels but lower ratio of free triiodothyronine(T3):T4(P<0.01).HOMA-βhad prominently negative correlation with FT4 and positive relationship with free T3:T4 in both groups even after adjusting for age,body mass index(BMI)and smoking.When analyzed by quartiles of FT4 or free T3:T4,there were significantly decreased trend of HOMA-β going with the higher FT4 and lower free T3:T4 in both groups.Linear regression analysis showed that FT4 but not FT3 and free T3:T4 was negatively associated with HOMA-β no matter in general population or T2DM patients,which was independent of age,BMI,smoking,hypertension and lipid profiles.FT4 is independently and negatively associated with islet beta-cell function in euthyroid subjects.Thyroid hormone even in reference range could play an important role in the function of pancreatic islets. 展开更多
关键词 free thyroxine free triiodothyronine islet beta-cell function euthyroid hormones diabetes
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EFFECTS OF GLUCAGON ON ISLET β CELL FUNCTION IN PATIENTS WITH DIABETES MELLITUS 认领 引用 被引量：7
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作者 Tong Wang Xin-hua Xiao Wen-hui Li Heng Wang Qi Sun Tao Yuan Guo-hua Yang 《Chinese Medical Sciences Journal》 CAS 2008年第2期117-120,共4页
Objective To evaluate islet β cell response to intravenous glucagon （ a non-glucose secretagogue） stimulation in diabetes mellitus. Methods Nineteen patients with type 1 diabetes （T1 D） and 131 patients with type... Objective To evaluate islet β cell response to intravenous glucagon （ a non-glucose secretagogue） stimulation in diabetes mellitus. Methods Nineteen patients with type 1 diabetes （T1 D） and 131 patients with type 2 diabetes （T2D） were recruited in this study. T2D patients were divided into two groups according to therapy： 36 cases treated with insulin and 95 cases treated with diet or oral therapy. The serum C-peptide levels were determined at fasting and six minutes after intra- venous injection of 1 mg of ghicagon. Results Both fasting and 6-minute post-ghicagon-stimulated C-peptide levels in T1D patients were significantly lower than those of T2D patients （0. 76±0. 36 ng/mL vs. 1.81±0. 78 ng/mL, P 〈 0.05 ; 0.88±0.42 ng/mL vs. 3.68±0. 98 ng/mL, P 〈 0. 05 ）. In T1D patients, the C-peptide level after injection of ghicagon was similar to the fasting level. In T2D, patients treated with diet or oral drug had a significantly greater fasting and stimulated C-peptide level than those patients received insulin therapy （2.45±0. 93 ng/mL vs. 1.61±0. 68 ng/mL, P 〈 0.05 ; 5.26±1.24 ng/mL vs. 2.15±0.76 ng/mL, P 〈 0.05 ）. The serum C-peptide level after ghicagon stimulation was positively correlated with C-peptide levels at fasting in all three groups （ r = 0.76, P 〈 0.05 ）. Conclusions The 6-minute ghicagon test is valuable in assessing the function of islet β cell in patients with diabetes mellitus. It is helpful for diagnosis and treatment of diabetes mellitus. 展开更多
关键词 glucagon diabetes mellitus C-peptide islet β cell function
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Relationship between imaging changes of the pancreas and islet beta-cell function 认领 引用
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作者 Hong-Jing Chen Yun Hu Jian-Hua Ma 《World Journal of Radiology》 2024年第12期717-721,共5页
Imaging changes in the pancreas can provide valuable information about the status of islet beta-cell function in different pancreatic diseases,such as diabetes,pancreatitis,pancreatic cancer,fatty pancreas,and insulin... Imaging changes in the pancreas can provide valuable information about the status of islet beta-cell function in different pancreatic diseases,such as diabetes,pancreatitis,pancreatic cancer,fatty pancreas,and insulinoma.While imaging cannot directly measure beta-cell function;it can be used as a marker of disease progression and a tool to guide therapeutic interventions.As imaging techno-logies continue to advance,they will likely play an increasingly important role in diagnosing,monitoring,and managing diabetes. 展开更多
关键词 Pancreas Imaging diagnosis Islet beta-cell function Diabetes Pancreatitis
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黄芪-黄连药对调控胰岛β细胞去分化对2型糖尿病小鼠胰岛功能的影响 认领 引用
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作者 李振华 陈源 +3 位作者 韩栩珂 张效科 岳仁宋 颜利伊 《天然产物研究与开发》 CAS CSCD 北大核心 2026年第5期942-951,共10页
探讨黄芪-黄连药对调控2型糖尿病(type 2 diabetes mellitus,T2DM)小鼠胰岛β细胞去分化改善胰岛功能的作用及潜在机制。通过高糖高脂饲料联合链脲佐菌素(streptozotocin,STZ)注射构建T2DM小鼠模型,随机分为空白组、模型组、二甲双胍组... 探讨黄芪-黄连药对调控2型糖尿病(type 2 diabetes mellitus,T2DM)小鼠胰岛β细胞去分化改善胰岛功能的作用及潜在机制。通过高糖高脂饲料联合链脲佐菌素(streptozotocin,STZ)注射构建T2DM小鼠模型,随机分为空白组、模型组、二甲双胍组及黄芪-黄连药对低、高剂量组。连续干预8周后,生化法检测空腹血糖(fasting blood glucose,FBG)、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)及高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)水平;ELISA法检测空腹胰岛素(fasting insulin,FINS)、游离脂肪酸(free fatty acids,FFA)水平;血糖测试仪检测口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)和腹腔注射胰岛素耐量试验(intraperitoneal insulin tolerance test,IPITT)血糖水平并计算曲线下面积(area under the curve,AUC);HE染色观察胰腺组织病理形态;免疫荧光法检测胰腺组织胰岛素(insulin,INS)表达;免疫组织化学法检测胰腺组织胰十二指肠同源盒因子1(pancreatic and duodenal homeobox 1,PDX1)和NANOG同源框蛋白(NANOG homeobox protein,NANOG)表达;Western blot检测磷酸化磷脂酰肌醇3-激酶(phosphorylated phosphoinositide 3-kinase,p-PI3K)、磷酸化蛋白激酶B(phosphorylated protein kinase B,p-AKT)、磷酸化叉头框蛋白O1(phosphorylated forkhead box protein O1,p-FOXO1)蛋白表达水平。结果表明,与空白组比较,模型组小鼠FBG升高,FINS降低,OGTT和IPITT试验的AUC增加(均P<0.01);TC、TG、LDL-C、FFA升高(P<0.01),而HDL-C降低(P<0.05);胰腺组织病理形态学显示胰岛结构紊乱、胰岛面积缩小并伴炎性浸润;胰腺组织中INS、PDX1、p-PI3K、p-AKT、p-FOXO1蛋白表达均降低而NANOG蛋白表达升高(P均<0.01)。与模型组比较,黄芪-黄连药对低、高剂量组小鼠的FBG降低,FINS升高,AUC降低(P<0.05或P<0.01);TC、TG、LDL-C降低(P<0.01或P<0.05),仅高剂量组FFA明显降低(P<0.05),各组HDL-C无明显差异;胰岛形态改善,炎性细胞浸润减轻;胰腺组织中INS、PDX1、p-AKT、p-FOXO1蛋白表达升高(P<0.01或P<0.05),仅高剂量组NANOG蛋白表达降低,p-PI3K蛋白表达升高(P<0.05)。总之,黄芪-黄连药对可通过抑制T2DM小鼠胰岛β细胞去分化,改善胰岛β细胞功能,其作用机制可能与激活PI3K/AKT/FOXO1通路有关。 展开更多
关键词 黄芪-黄连药对 2型糖尿病 胰岛β细胞 去分化 胰岛功能
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利拉鲁肽联合硫辛酸治疗痛性糖尿病周围神经病变疗效观察 认领 引用
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作者 陈雪辉 白立炜 +6 位作者 尹清风 孟祥雨 徐云 王迪 王旭 耿锐娜 刘秋君 《河南医药大学学报》 CAS 2026年第7期552-557,共6页
目的探讨利拉鲁肽联合硫辛酸治疗痛性糖尿病周围神经病变(PDPN)的临床疗效。方法选择2021年9月至2023年9月新乡医学院第一附属医院收治的102例PDPN患者为研究对象,按照随机数字表法将患者分为对照组和观察组,每组51例。对照组患者给予... 目的探讨利拉鲁肽联合硫辛酸治疗痛性糖尿病周围神经病变(PDPN)的临床疗效。方法选择2021年9月至2023年9月新乡医学院第一附属医院收治的102例PDPN患者为研究对象,按照随机数字表法将患者分为对照组和观察组,每组51例。对照组患者给予硫辛酸治疗,观察组患者给予利拉鲁肽联合硫辛酸治疗,对比2组患者治疗前、治疗3个月后空腹血糖、胰岛功能、血糖变异性、临床症状评分[自发性疼痛视觉模拟评分法(VAS)评分、刺激诱发性疼痛VAS评分、医院性焦虑和抑郁量表(HADS)-焦虑评分、HADS-抑郁评分]、神经传导速度、枯草溶菌素转化酶9(PCSK9)、成纤维细胞生长因子-21(FGF-21)、巨噬细胞炎症蛋白-1α(MIP-1α)水平变化。结果治疗3个月后,2组患者空腹血糖、餐后2 h血糖、胰岛素抵抗指数、糖化血红蛋白、平均血糖波动幅度、日内最大血糖波动幅度、空腹血糖变异系数、全天血糖标准差、自发性疼痛VAS评分、刺激诱发性疼痛VAS评分、HADS-焦虑评分、HADS-抑郁评分均显著低于治疗前,且观察组显著低于对照组(P<0.05);治疗3个月后,2组患者腓总神经感觉神经传导速度、正中神经感觉神经传导速度、腓总神经运动神经传导速度、正中神经运动神经传导速度均显著高于治疗前,且观察组显著高于对照组(P<0.05);治疗3个月后,2组患者血清PCSK9、FGF-21、MIP-1α水平均显著低于治疗前,且观察组显著低于对照组(P<0.05)。结论利拉鲁肽联合硫辛酸治疗PDPN可显著改善患者临床症状、血糖代谢、胰岛功能、血糖变异性,提高神经传导速度,这可能与其抑制PCSK9、FGF-21及MIP-1α表达有关。 展开更多
关键词 痛性糖尿病周围神经病变 糖尿病 利拉鲁肽 硫辛酸 血糖变异性 神经传导 胰岛功能
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2型糖尿病患者血清成纤维细胞生长因子21与空腹C肽之间的关系分析 认领 引用
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作者 杨艾利 鱼馨文 +6 位作者 孙飞 靳玉欣 王新 张文成 王美璎 赵国宏 高彬 《空军军医大学学报》 CAS 2026年第8期1175-1180,共6页
目的探究2型糖尿病(T2DM)患者血清成纤维细胞生长因子21(FGF21)水平与空腹C肽(FCP)之间的关系,寻找FGF21与胰岛β细胞功能相关性的证据。方法纳入2023年6月至12月期间在空军军医大学唐都医院内分泌科住院的265例T2DM患者。收集患者的临... 目的探究2型糖尿病(T2DM)患者血清成纤维细胞生长因子21(FGF21)水平与空腹C肽(FCP)之间的关系,寻找FGF21与胰岛β细胞功能相关性的证据。方法纳入2023年6月至12月期间在空军军医大学唐都医院内分泌科住院的265例T2DM患者。收集患者的临床资料,包括年龄、性别、病程等基本信息,以及血清FGF21、FCP、空腹血糖等检测结果。所有患者根据FCP水平被分为3组:胰岛素分泌不足型组(FCP≤1.0μg/L)、胰高血糖素样肽1分泌不足型组(1.0μg/L<FCP<2.5μg/L)以及胰岛素抵抗型组(FCP≥2.5μg/L)。采用单因素方差分析或Kruskal-Wallis秩和检验比较3组之间各项指标的差异,然后分别通过多元线性回归分析和多元有序logistic回归分析探讨FGF21与FCP的关系。结果在3组中,体质量指数(BMI)、舒张压、糖化血红蛋白(HbA1c)、甘油三酯、FGF21以及使用胰岛素、胰岛素促泌剂的比例存在显著差异(均P<0.05)。单因素线性回归表明BMI、病程、舒张压、FGF21、HbA1c、应用胰岛素、应用胰岛素促泌剂与FCP显著相关(均P<0.05)。多因素线性回归分析结果表明,FGF21[β=0.144,95%CI(0.041,0.370),P=0.015]与T2DM患者的FCP具有显著相关性。多元有序logistic回归分析结果也显示,相较于FGF21第一分位,第三分位FGF21[OR=2.815,95%CI(1.467,5.403),P=0.002]与T2DM患者FCP的升高显著相关。结论在T2DM患者中,较高的FGF21水平与FCP的升高显著相关,这提示FGF21可能对T2DM患者的胰岛功能具有潜在保护作用。 展开更多
关键词 2型糖尿病 成纤维细胞生长因子21 空腹C肽 胰岛功能
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基于胰腺CT评估不同糖耐量受损人群胰腺脂肪成分占比及与胰岛功能相关性 认领 引用
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作者 张梦琪 李晶晶 +1 位作者 刘烁 陈杰 《中国CT和MRI杂志》 2026年第2期108-111,共4页
目的基于胰腺CT评估不同糖耐量受损人群胰腺脂肪成分占比及其与胰岛功能相关性。方法选取本院178例接受口服葡萄糖耐量试验(OGTT)的糖耐量受损者作为研究对象,根据糖耐量受损情况,分为4组:空腹血糖受损(IFG)组、糖耐量减低(IGT)组、IFG+... 目的基于胰腺CT评估不同糖耐量受损人群胰腺脂肪成分占比及其与胰岛功能相关性。方法选取本院178例接受口服葡萄糖耐量试验(OGTT)的糖耐量受损者作为研究对象,根据糖耐量受损情况,分为4组:空腹血糖受损(IFG)组、糖耐量减低(IGT)组、IFG+IGT组与新诊断2型糖尿病(T2DM)组,使用胰腺CT评估胰腺脂肪成分占比,分析胰腺脂肪成分占比与胰岛功能[空腹胰岛素(FINS)、饭后2h胰岛素(2h INS)、β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)]的相关性。结果胰腺脂肪脂肪成分占比为:T2DM组(19.72±3.50)%>IFG+IGT组(16.09±3.14)%>IFG组(11.42±2.38)%>IGT组(9.98±1.85)%,差异有统计学意义(PIGT组[(27.74±4.20)μU/mL、(93.78±15.35)μU/mL]与IFG+IGT组[(27.81±4.25)μU/mL、(93.29±16.54)μU/mL]>IFG组[(3.19±0.83)μU/mL、(23.16±5.08)μU/mL],差异有统计学意义(PIFG组(43.71±5.54)%与IFG+IGT组(42.69±5.56)%>T2DM组(33.39±7.48)%,差异有统计学意义(PIFG+IGT组(0.91±0.16)>IFG组(0.69±0.12)>IGT组(0.31±0.08),差异有统计学意义(P<0.05);FINS、2h INS、HOMA-IR与胰腺脂肪成分占比呈正相关(r=0.345、0.459、0.689,P<0.05),HOMA-β与胰腺脂肪成分占比呈负相关(r=-0.576,P<0.05)。结论IFG、IFG+IGT、T2DM人群胰腺脂肪成分占比逐渐升高,且与FINS、2hINS、HOMA-IR、HOMA-β密切相关。 展开更多
关键词 糖耐量受损 胰腺 脂肪 CT 胰岛功能
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杞菊地黄汤加减联合胰岛素治疗妊娠期糖尿病的临床效果观察 认领 引用
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作者 李乾胜 段红福 +1 位作者 马中华 刘永新 《贵州医药》 CAS 2026年第3期463-466,共4页
目的探讨妊娠期糖尿病(GDM)行杞菊地黄汤加减与胰岛素联合治疗妊娠期糖尿病的效果。方法选取我院妇产科150例GDM患者,采用随机数字表法将其分为对照组和观察组,各75例。对照组予以单一胰岛素治疗,观察组予以杞菊地黄汤加减联合胰岛素治... 目的探讨妊娠期糖尿病(GDM)行杞菊地黄汤加减与胰岛素联合治疗妊娠期糖尿病的效果。方法选取我院妇产科150例GDM患者,采用随机数字表法将其分为对照组和观察组,各75例。对照组予以单一胰岛素治疗,观察组予以杞菊地黄汤加减联合胰岛素治疗,观察两组的临床治疗效果。结果观察组总治疗有效率高于对照组(97.33%VS 82.67%,P<0.05);治疗后,观察组血糖、胰岛功能、脂肪因子指标水平以及中医症候积分均优于对照组(P<0.05);观察组不良围产结局总发生率低于对照组(2.67%VS 13.33%,P<0.05)。结论杞菊地黄汤加减、胰岛素联合治疗对GDM效果显著,其不仅可改善胰岛功能、中医证候,控制血糖,同时还可调节脂肪因子,最大限度避免不良围产结局发生。 展开更多
关键词 杞菊地黄汤加减 围产结局 胰岛功能 妊娠期糖尿病
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利拉鲁肽联合卡格列净治疗2型糖尿病的效果及对血清脂肪因子和炎症因子水平的影响 认领 引用
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作者 杨磊磊 梁鹏 赵宁 《临床和实验医学杂志》 2026年第4期368-372,共5页
目的探讨利拉鲁肽联合卡格列净治疗2型糖尿病(T2DM)的效果及对血清脂肪因子和炎症因子水平的影响。方法前瞻性选取2023年1月至2024年12月就诊于北京市垂杨柳医院的104例T2DM患者作为研究对象。按照随机数字表法将患者分为对照组与联合组... 目的探讨利拉鲁肽联合卡格列净治疗2型糖尿病(T2DM)的效果及对血清脂肪因子和炎症因子水平的影响。方法前瞻性选取2023年1月至2024年12月就诊于北京市垂杨柳医院的104例T2DM患者作为研究对象。按照随机数字表法将患者分为对照组与联合组,每组各52例。对照组予以卡格列净治疗,联合组予以利拉鲁肽联合卡格列净治疗,两组均治疗3个月。治疗前、治疗3个月后,检测患者血糖指标[空腹血糖、餐后2 h血糖(2 h PPG)、糖化血红蛋白(GHb)]、胰岛功能[空腹C肽、餐后2 h C肽(2 h CP)、稳态模型评估胰岛素抵抗指数(HOMA-IR)]、脂肪因子(鸢尾素、降脂素、瘦素)和炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,并对比组间差异。结果治疗3个月后,两组患者的空腹血糖、2 h PPG和GHb均较治疗前显著降低,且联合治疗组的空腹血糖、2 h PPG和GHb均低于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,两组患者的HOMA-IR均较治疗前显著降低,FCP和2 h CP水平均较治疗前上升,且联合治疗组的HOMA-IR低于对照组,CP和2 h CP水平均高于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,两组患者的血清鸢尾素、降脂素水平均较治疗前显著提升,瘦素均较治疗前显著降低,且联合治疗组的血清鸢尾素、降脂素水平均高于对照组,瘦素低于对照组,差异均有统计学意义(P<0.05)。治疗3个月后,两组患者的血清IL-6、TNF-α水平均较治疗前显著降低,且联合治疗组的血清IL-6、TNF-α水平均低于对照组,差异均有统计学意义(P<0.05)。结论利拉鲁肽联合卡格列净用于血糖控制不佳的T2DM患者降糖治疗,可提升血糖控制效果,改善胰岛功能,其机制可能与调节脂肪因子和减轻炎症有关。 展开更多
关键词 2型糖尿病 利拉鲁肽 卡格列净 胰岛功能 脂肪因子 炎症因子
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德谷门冬双胰岛素联合二甲双胍治疗2型糖尿病的效果及对血糖水平的影响 认领 引用
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作者 孟海艳 李佳伟 +3 位作者 米高琴 陈慧雅 石忠月 谷沛 《临床合理用药》 2026年第21期25-28,共4页
目的观察德谷门冬双胰岛素联合二甲双胍治疗2型糖尿病的效果及对血糖水平的影响。方法选取2024年1月—2025年10月于国药同煤总医院内分泌科诊治的2型糖尿病患者96例,以随机数字表法分为观察组(n=48,应用德谷门冬双胰岛素联合二甲双胍治... 目的观察德谷门冬双胰岛素联合二甲双胍治疗2型糖尿病的效果及对血糖水平的影响。方法选取2024年1月—2025年10月于国药同煤总医院内分泌科诊治的2型糖尿病患者96例,以随机数字表法分为观察组(n=48,应用德谷门冬双胰岛素联合二甲双胍治疗)和对照组(n=48,仅应用二甲双胍治疗),2组均连续治疗3个月。比较2组临床疗效,治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)]、胰岛功能指标[空腹胰岛素(FINS)、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)]、抗氧化指标[血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、总抗氧化能力(T-AOC)]。结果观察组治疗总有效率为93.75%,高于对照组的79.17%(χ2=4.360,P=0.037)。治疗3个月后,2组FPG、2 hPG、HbA1c水平低于治疗前,且观察组低于对照组(P<0.01);2组FINS、HOMA-IR低于治疗前,HOMA-β高于治疗前,且观察组低/高于对照组(P<0.01);2组SOD、CAT、T-AOC水平高于治疗前,且观察组高于对照组(P<0.01)。结论德谷门冬双胰岛素联合二甲双胍治疗2型糖尿病临床效果较佳,可有效降低血糖,改善胰岛功能,增强机体抗氧化能力。 展开更多
关键词 2型糖尿病 德谷门冬双胰岛素 二甲双胍 血糖 胰岛功能 抗氧化指标
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5例次同种异体胰岛细胞移植患者术后早期胰岛功能恢复的护理观察 认领 引用
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作者 张红霞 高丽 +4 位作者 罗新春 刘颖翠 叶海丹 胡安斌 何晓顺 《中西医结合护理》 2026年第3期86-91,共6页
总结同种异体胰岛细胞移植患者术后早期胰岛功能恢复的临床特点和护理经验,为此类患者早期胰岛功能恢复提供实践参考依据。对4例患者共施行5例次同种异体胰岛细胞移植术。实施动态血糖监测,做好胰岛功能相关各项指标的采集、送检及观察... 总结同种异体胰岛细胞移植患者术后早期胰岛功能恢复的临床特点和护理经验,为此类患者早期胰岛功能恢复提供实践参考依据。对4例患者共施行5例次同种异体胰岛细胞移植术。实施动态血糖监测,做好胰岛功能相关各项指标的采集、送检及观察护理工作,保证检验结果的准确性与时效性。4例患者接受5例次同种异体胰岛细胞移植,术后均未发生低血糖反应,血糖水平维持在3.9~11.9 mmol/L。其中3例次实现胰岛素间断停用,1例次胰岛素的使用量较术前减少明显,1例次在胰岛细胞移植后的6个月后出现血糖复升,接受二次同种异体胰岛细胞移植,术后胰岛功能恢复良好。对同种异体胰岛细胞移植术后患者胰岛功能进行临床护理观察,正确监测血糖,以及按医嘱及时采集标本进行实验室检查,是全面促进术后早期胰岛功能恢复的关键措施。 展开更多
关键词 胰岛细胞移植 糖尿病 胰岛功能 血糖
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马齿苋与金莲花饮片联合二甲双胍治疗2型糖尿病患者的效果 认领 引用
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作者 谢文松 仇丽伟 +1 位作者 常香云 沈莺 《中国民康医学》 2026年第15期115-118,共4页
目的:观察马齿苋与金莲花饮片联合二甲双胍治疗2型糖尿病患者的效果。方法:回顾性分析2023年1月至2024年6月该院收治的84例2型糖尿病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各42例。对照组采用二甲双胍治疗,观察组在对... 目的:观察马齿苋与金莲花饮片联合二甲双胍治疗2型糖尿病患者的效果。方法:回顾性分析2023年1月至2024年6月该院收治的84例2型糖尿病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各42例。对照组采用二甲双胍治疗,观察组在对照组基础上联合马齿苋与金莲花饮片治疗。比较两组临床疗效,治疗前后胰岛功能指标[空腹胰岛素(FINS)、稳态模型评估胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.86%,高于对照组的76.19%,差异有统计学意义(P0.05)。结论:马齿苋与金莲花饮片联合二甲双胍治疗2型糖尿病患者可提高治疗总有效率,改善胰岛功能指标、血脂指标、炎性因子及氧化应激指标水平,效果优于单纯二甲双胍治疗。 展开更多
关键词 马齿笕 金莲花 二甲双胍 2型糖尿病 胰岛功能 血脂 炎性因子 氧化应激
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肝肾同调理论在老年2型糖尿病患者临床治疗中的应用进展 认领 引用
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作者 曹宏业 张军 《糖尿病新世界》 2026年第11期190-194,共5页
2型糖尿病是老年群体常见的慢性代谢性疾病,其发病进展与肝肾功能密切相关。肝肾同调理论为老年2型糖尿病的防治提供了重要理论基础,本文从肝肾同调理论出发,系统性阐述疾病发生进展机制以及近些年基于肝肾同调理论衍生的诸多中医特色... 2型糖尿病是老年群体常见的慢性代谢性疾病,其发病进展与肝肾功能密切相关。肝肾同调理论为老年2型糖尿病的防治提供了重要理论基础,本文从肝肾同调理论出发,系统性阐述疾病发生进展机制以及近些年基于肝肾同调理论衍生的诸多中医特色疗法。通过深入分析其核心病机及治疗决策,可为此类患者群体临床诊治工作开展提供关键数据支持。 展开更多
关键词 2型糖尿病 老年 肝肾同调 血糖 胰岛功能 中医 联合疗法
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二甲双胍联合德谷门冬双胰岛素治疗2 型糖尿病的临床效果分析 认领 引用
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作者 潘美时 杨斌 +2 位作者 黄丽娜 劳志醒 李雪英 《中外医药研究》 2026年第3期40-42,共3页
目的:探究二甲双胍联合德谷门冬双胰岛素治疗对2型糖尿病患者的影响。方法:选取百色市人民医院2021年6月—2023年6月收治的2型糖尿病患者100例,按随机数字表法分为两组,各50例。对照组采用二甲双胍联合阿卡波糖治疗,观察组采用二甲双胍... 目的:探究二甲双胍联合德谷门冬双胰岛素治疗对2型糖尿病患者的影响。方法:选取百色市人民医院2021年6月—2023年6月收治的2型糖尿病患者100例,按随机数字表法分为两组,各50例。对照组采用二甲双胍联合阿卡波糖治疗,观察组采用二甲双胍联合德谷门冬双胰岛素治疗。比较两组治疗效果。结果:观察组总有效率高于对照组(P=0.023);治疗后,观察组各项血糖指标水平低于对照组(P0.05)。结论:二甲双胍联合德谷门冬双胰岛素能有效提高2型糖尿病患者临床疗效,改善患者血糖及C肽水平,促进胰岛功能恢复,且安全性良好。 展开更多
关键词 二甲双胍 德谷门冬双胰岛素 2型糖尿病 胰岛功能
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司美格鲁肽联合瑞格列奈治疗肥胖2型糖尿病的效果及对胰岛功能、身体成分的影响 认领 引用 被引量：2
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作者 冯娟娟 马沙 +1 位作者 李柏龄 杨海波 《海南医学》 CAS 2026年第1期14-19,共6页
目的 探讨司美格鲁肽联合瑞格列奈对肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者的治疗效果。方法 选取洛阳市东方人民医院2022年1月至2024年9月收治的肥胖T2DM患者102例,随机分为观察组和对照组,各51例。两组均给予基础治疗,对... 目的 探讨司美格鲁肽联合瑞格列奈对肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)患者的治疗效果。方法 选取洛阳市东方人民医院2022年1月至2024年9月收治的肥胖T2DM患者102例,随机分为观察组和对照组,各51例。两组均给予基础治疗,对照组给予瑞格列奈,观察组给予司美格鲁肽联合瑞格列奈,疗程3个月。治疗3个月后比较两组患者的治疗效果,以及治疗前后糖化血红蛋白(HbA1c)、胰岛β细胞功能指数(HOMA-β)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、空腹胰岛素(FINS)、总胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)、肌肉量、脂肪量、体脂比、内脏脂肪面积及不良反应发生率。结果 治疗后观察组患者的FPG、2 hPG、HbA1c水平分别为(7.06±0.64) mmol/L、(7.15±1.12) mmol/L、(6.63±0.54)%,明显低于对照组的(7.64±0.70) mmol/L、(8.17±1.25) mmol/L、(7.20±0.62)%,差异均有统计学意义(P0.05)。结论 司美格鲁肽联合瑞格列奈治疗肥胖T2DM患者可改善胰岛功能,调控血糖血脂水平,减少体脂,安全有效。 展开更多
关键词 2型糖尿病 肥胖 司美格鲁肽 瑞格列奈 胰岛功能
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