Diabetic retinopathy(DR)is a glucose-defining complication with varying prevalence reported depending upon the duration of diabetes,degree of glycemic control,and associated other microvascular complications,particula...Diabetic retinopathy(DR)is a glucose-defining complication with varying prevalence reported depending upon the duration of diabetes,degree of glycemic control,and associated other microvascular complications,particularly nephropathy,defined by albuminuria and reduced glomerular filtration rate.The prevalence of DR also varies with the diabetes phenotype,with ketosis-prone diabetes having DR as prevalent as type 2 diabetes,but less than type 1 diabetes,matched for age and gender.An increasing prevalence in ketosis-prone diabetes plausibly could be due to ketonemia increasing permeability of blood-retinal layer contributing to inflammation.The guidelines for initial screening and evaluation of DR suggest similar strategies across diabetes phenotypes.Recent advances in DR diagnosis with advanced imaging technologies with artificial intelligence shall enable earlier detection with improved accuracy across varied diabetes phenotypes to reduce preventable blindness due to DR.展开更多
摘要Diabetic retinopathy(DR)is a glucose-defining complication with varying prevalence reported depending upon the duration of diabetes,degree of glycemic control,and associated other microvascular complications,particularly nephropathy,defined by albuminuria and reduced glomerular filtration rate.The prevalence of DR also varies with the diabetes phenotype,with ketosis-prone diabetes having DR as prevalent as type 2 diabetes,but less than type 1 diabetes,matched for age and gender.An increasing prevalence in ketosis-prone diabetes plausibly could be due to ketonemia increasing permeability of blood-retinal layer contributing to inflammation.The guidelines for initial screening and evaluation of DR suggest similar strategies across diabetes phenotypes.Recent advances in DR diagnosis with advanced imaging technologies with artificial intelligence shall enable earlier detection with improved accuracy across varied diabetes phenotypes to reduce preventable blindness due to DR.