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Effect of hemoperfusion and hemofiltration in lead clearance: a case report 认领 引用
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作者 Jiaqi Xu Qing Tang +3 位作者 Lina Jiao Xin Luo Songtao Shou Lijun Wang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第4期400-402,共3页
Lead poisoning mainly results from inhaling leadcontaining dust or aerosols, ingesting contaminated food/water, or contact with lead-based paint.[1] Lead poisoning symptoms include headaches, dizziness, fatigue, memor... Lead poisoning mainly results from inhaling leadcontaining dust or aerosols, ingesting contaminated food/water, or contact with lead-based paint.[1] Lead poisoning symptoms include headaches, dizziness, fatigue, memory impairment, sleep disorders, joint and muscle aches, peripheral neuropathy, abdominal pain, bloating, constipation, and anemia. Severe cases may cause muscle paralysis and toxic encephalopathy.[2] In adults, lead poisoning is defined as blood lead level(BLL) ≥100 μg/L. 展开更多
关键词 sleep disorders abdominal pain lead poisoning inhaling leadcontaining dust muscle paralysis hemoperfusion toxic encephalopathy peripheral neuropathy
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Influence mechanism and optimization of aerodynamic efficiency in a compressor stator blade with wavy leading-edge 认领 引用
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作者 Haoguang ZHANG Ruizheng YANG +2 位作者 Yiming FENG Yue LI Wuli CHU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第7期189-214,共26页
This paper investigates the flow control mechanisms of wavy leading-edge parameters through parametric optimization of the stator blade in a single-stage axial flow compressor.The optimal configuration with 2%stator b... This paper investigates the flow control mechanisms of wavy leading-edge parameters through parametric optimization of the stator blade in a single-stage axial flow compressor.The optimal configuration with 2%stator blade tip axial chord length amplitude,15%span wavelength,and crest-trough arrangement near the shroud improves peak efficiency by 0.93%.Detailed loss analysis shows this design reduces endwall separation losses by approximately 50%compared to original configuration.The research reveals three key mechanisms:First,increasing the wavy leading-edge amplitude enhances the strength of the leading-edge vortex pairs,which subsequently promotes the formation of leading-edge mixing vortices to disrupt the corner separation vortices.However,excessive amplitude introduces additional flow losses.Second,the large-wavelength configuration generates weaker leading-edge vortex pairs,while the small-wavelength design enhances vortex pair intensity at the expense of reduced radial induction capability for near-shroud flow.Consequently,an optimal wavelength exists,which simultaneously maintains effective radial flow induction to alleviate blockage near the shroud and generates sufficient leading-edge mixing vortices to suppress corner separation.Third,although the phase arrangement does not affect vortex pair strength,the crest-trough alignment near the shroud provides optimal improvement for shroudendwall corner separation.The middle-crest configuration near the hub effectively enhances boundary layer attachment in the lower span region. 展开更多
关键词 Aerodynamic optimization Compressor stator blade Computational fluid dynamics Flow control Flow mechanism Wavy leading edge
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AgNbO3-based lead-free antiferroelectric ceramics for energy storage 认领 引用
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作者 Lei Zhao Ziyu Wu +1 位作者 Jing-Feng Li Jing Wang 《Journal of Materiomics》 SCIE EI CSCD 2026年第4期63-65,共3页
Antiferroelectric(AFE)materials,which exhibit typical double polarization-electric field(PE)loops,are characterized by a linear polarization response at low electric fields and a transition to ferroelectric(FE)-like p... Antiferroelectric(AFE)materials,which exhibit typical double polarization-electric field(PE)loops,are characterized by a linear polarization response at low electric fields and a transition to ferroelectric(FE)-like polarization behavior at high electric fields.These materials show exceptional promise for high-capacitance-density capacitors due to their large reversible polarization dur-ing electric field cycling.Lead-based AFE materials,exemplified by PbZrO3 and PbHfO3,have dominated the field for decades due to their outstanding energy storage performance. 展开更多
关键词 energy storage lead free antiferroelectric ceramics PbZrO capacitors polarization electric field linear polarization response
Machine learning-based detection of diabetes mellitus from singlelead electrocardiography:A phenotype-stratified approach 认领 引用 被引量：2
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作者 Anna Dmitrievna Karbovskaya Basheer Abdullah Marzoog +9 位作者 Anastasia Stroeva Alexander Suvorov Peter Chomakhidze Daria Gognieva Natalia Kuznetsova Philipp Kopylov Abromavich Syrkin Valentin V Fadeev Sevindzh M Ismailova Irina V Poluboyarinova 《World Journal of Cardiology》 2026年第3期78-92,共15页
BACKGROUND Diabetes mellitus(DM)and the related sequalae remains one of the most frequently reported cause of morbidity and mortality in our era.This returns to the non-sufficient screening methods for DM at early sta... BACKGROUND Diabetes mellitus(DM)and the related sequalae remains one of the most frequently reported cause of morbidity and mortality in our era.This returns to the non-sufficient screening methods for DM at early stages.AIM To assess the diagnostic capabilities of the parameters of single lead electrocardiography(ECG)in the diagnosis of DM utilizing machine learning model.METHODS A single center study involved 629 participants with vs without DM.All the study participants passed transthoracic echocardiography,fasting blood glucose measurement,standard 12-lead ECG recording,and single lead ECG registration using the Cardio-Qvark®device.A gradient boosting machine model,specifically the XGBoost implementation,was developed using R v4.2 and Python v3.10.The model was trained and validated using a novel cluster-stratified approach-training on three phenotypic clusters and testing on the fourth-to isolate DM-specific ECG signatures from confounding cardiovascular disease.RESULTS The cluster-stratified analysis revealed that the model performed best in cluster 4(patients with high DM prevalence and significant comorbidities),achieving a sensitivity of 75%,specificity of 83%,and an area under the curve of 88%.CONCLUSION This study demonstrates that a phenotype-stratified approach is crucial for effective ECG-based DM screening.By identifying a specific clinical profile(cluster 4:High comorbidity burden with preserved cardiac function),we developed a model that accurately detects DM from a single-lead ECG.This phenotype-specific strategy overcomes the confounding effect of cardiovascular disease,moving beyond one-size-fits-all algorithms towards a precise and clinically viable tool for non-invasive DM detection in high-risk populations. 展开更多
关键词 Diabetes mellitus Machine learning model Diagnosis Single lead electrocardiography Hyperglycemia Metabolic syndrome
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Exceptional one-dimensional hybrid lead halide for high-performance X-ray detection through hydrogen bond enhanced charge transport 认领 引用 被引量：1
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作者 Xue-Na Tang Qingshun Fan +2 位作者 Guang-Ning Liu Cuncheng Li Zhihua Sun 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期624-629,共6页
The immense potential of one-dimensional(1D)hybrid lead halide perovskites(HLHPs)in single crystal X-ray detection is hindered by their relatively low charge transport abilities and needle-like morphology.Alloying mix... The immense potential of one-dimensional(1D)hybrid lead halide perovskites(HLHPs)in single crystal X-ray detection is hindered by their relatively low charge transport abilities and needle-like morphology.Alloying mixed cations in 1D HLHP is expected to realize superior charge mobility and large single crystals.Herein,we report a 1D HLHP of(ATZ)(EA)4Pb3I11(1)with thiazol-2-aminium(ATZ)+and ethanaminium(EA)+as the mixed cations,demonstrating an exceptional 1D HLHP for high-performance X-ray detector.The H…I hydrogen bonds with a fraction of 69.7%are stronger than those in 1D HLHPs containing solely(ATZ)+or(EA)+cations.The single crystal of 1 posesses remarkable semiconducting properties,including a high resistivity(1.94×1011Ωcm)and a large mobility-lifetime product(2.22×10−4cm2/V),which contribute to the outstanding X-ray detection,manifested by a high sensitivity of 1356μC Gyair−1cm−2and an ultra-low dark current drift of 5.01×10−8nA cm-1 s−1V−1. 展开更多
关键词 Lead halide Inorganic-organic hybrid Hydrogen bonds Mixed cation X-ray detection
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数智时代专创融合的LEADS-P范式建构——基于《创新创业教育》金课的行动研究 认领 引用
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作者 连仙枝 《漳州职业技术学院学报》 2026年第3期94-102,共9页
以行动研究为方法论框架,依托晋城职业技术学院学前教育专业《创新创业教育》课程,建构并验证了一个专创融合的实践范式——LEADS-P。以156名五年制大专学前教育专业学生为研究对象,历经三轮“计划—行动—观察—反思”的循环实践,通过... 以行动研究为方法论框架,依托晋城职业技术学院学前教育专业《创新创业教育》课程,建构并验证了一个专创融合的实践范式——LEADS-P。以156名五年制大专学前教育专业学生为研究对象,历经三轮“计划—行动—观察—反思”的循环实践,通过半结构化访谈收集质性资料,并借助NVivo 15进行系统编码分析。研究结果表明,LEADS-P范式能够有效破解专创融合中“形式化融合”与“结构性割裂”的双重困境,驱动课堂教学从知识传授向价值创造转型。学生的创新素养、实践能力及专业认同感均有显著提升。基于该范式的课程实践成功获批2025年山西省职业教育社会实践“金课”。本研究为高职院校学前教育及其他专业推进专创融合提供了具有可操作性的实践路径与理论参考。 展开更多
关键词 数智时代 专创融合 LEADS-P范式 创新创业教育 行动研究
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Role of gut microbiota in lead-induced neural damage in diabetic mice 认领 引用 被引量：1
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作者 Wen-Jia Ding Chao-Qun Liu +7 位作者 Xin-Yi Tang Zhi-Bin Shang Xu Liang Tao Tao Ru-Xi Liu Qiong-Yun Jiang Yan-Fang Qiu Yi Sun 《World Journal of Diabetes》 SCIE 2026年第1期164-179,共16页
BACKGROUND China has the highest incidence of diabetes among all Asian countries,and environmental factors have a significant impact on the onset of diabetes.Lead is one of the important legacy environmental pollutant... BACKGROUND China has the highest incidence of diabetes among all Asian countries,and environmental factors have a significant impact on the onset of diabetes.Lead is one of the important legacy environmental pollutants that disrupts endocrine function.Both lead and diabetes have damaging effects on the nervous system,while the gut microbiota is considered an important mediator of brain damage.AIM To determine the effects and underlying mechanisms of environmental lead exposure and diabetes on neural function.METHODS A mouse model of lead exposure and diabetes was used.Lead levels were measured using inductively coupled plasma mass spectrometry,and blood glucose levels were assessed.Immunofluorescence was used to analyze brain damage in mice.The Morris water maze was used for evaluating neural function.Neurotransmitters including vanillylmandelic acid,5-hydroxyindoleacetic acid,3,4-dihydroxyphenylacetic acid(DOPAC),and homovanillic acid(HVA)were quantified with high performance liquid chromatography.Proteomics analysis was conducted on hippocampal brain tissue,and gut microbiota analysis was performed on colonic fecal samples.PI3K and COX2 proteins were detected by Western blotting,and then glutathione(GSH)levels in brain tissue were measured.RESULTS Mice in the lead-exposure diabetic model exhibited significantly elevated lead and blood glucose levels,with the most severe neural damage observed.The neurotransmitters DOPAC and HVA were markedly increased.Proteomics revealed that differential proteins were primarily involved in neural and metabolic pathways.Correlation analysis between the top 20 gut microbiota and differential proteins identified Sutterella as the most associated gut microbe with proteins.The levels of COX2,PI3K,and GSH in the mouse brain provided preliminary validation of these findings.CONCLUSION The coexistence of lead exposure and diabetes has an interactive effect on neural damage.This interaction appears to affect the abundance of the gut microbe Sutterella,which,through inflammation,influences the expression of related differential proteins in the brain,ultimately resulting in neural damage. 展开更多
关键词 Diabetes Lead exposure Proteomics Gut microbiota Neurotoxicity
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Recovery of Lead-Zinc Slags to Methyl-Ammonium Lead Tri-Iodide With Single-Atom Fe-N4Sites for Piezocatalytic Hydrogen Evolution 认领 引用 被引量：1
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作者 Fangyan Liu Mengye Wang +6 位作者 Jiawen Liu Feng Gao Jiahui Lin Jiaqing He Feng Zhu Chuan Liu Zhang Lin 《Carbon Energy》 SCIE EI CSCD 2025年第8期26-36,共11页
Lead(Pb)-zinc(Zn)slags contain large amounts of Pb,causing irreversible damage to the environment.Therefore,developing an effective strategy to extract Pb from Pb-Zn slags and convert them into a renewable high-value ... Lead(Pb)-zinc(Zn)slags contain large amounts of Pb,causing irreversible damage to the environment.Therefore,developing an effective strategy to extract Pb from Pb-Zn slags and convert them into a renewable high-value catalyst not only solves the energy crisis but also reduces environmental pollution.Herein,we present a viable strategy to recycle Pb and iron(Fe)from Pb-Zn slags for the fabrication of efficient methylammonium lead tri-iodide(r-MAPbI3)piezocatalysts with single-atom Fe-N4 sites.Intriguingly,atomically dispersed Fe sites from Pb-Zn slags,which coordinated with N in the neighboring four CH3NH3 to form the FeN4 configuration,were detected in the as-obtained r-MAPbI3 by synchrotron X-ray absorption spectroscopy.The introduction of Fe single atoms amplified the polarization of MAPbI3 and upshifted the d-band center of MAPbI3.This not only enhanced the piezoelectric response of MAPbI3 but also promoted the proton transfer during the hydrogen evolution process.Due to the decoration of Fe single atoms,r-MAPbI3 showed a pronounced H2 yield of 322.4μmol g−1 h−1,which was 2.52 times that of MAPbI3 synthesized using commercially available reagents.This simple yet robust strategy to manufactureMAPbI3 piezocatalysts paves a novel way to the large-scale and value-added consumption of Pb-containing waste residues. 展开更多
关键词 lead extraction lead-zinc slags methylammonium lead tri-iodide piezoelectric catalysis single-atom Fe sites
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Magnetotactic bacteria antagonized lead toxicity:Distinct detoxification mechanisms in magnetosome-containing/deficient bacteria 认领 引用
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作者 Ruoyun Dong Yuting Ding +5 位作者 Han Li Yanan Zhao Yuanyuan Wu Chenxi Zhou An Xu Yun Liu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期247-258,共12页
Lead(Pb),a highly toxic heavy metal pollutant with a long biological half-life and environmental persistence,has posed serious threats to global health.However,efficient and safe detoxification methods for Pb poisonin... Lead(Pb),a highly toxic heavy metal pollutant with a long biological half-life and environmental persistence,has posed serious threats to global health.However,efficient and safe detoxification methods for Pb poisoning remain lacking.In this study,Magnetospirillum magneticum AMB-1 containing magnetosomes(M-AMB-1)and magnetosome-deficient AMB-1(NM-AMB-1)were selected to comparatively explore the detoxification efficacies of magnetotactic bacteria(MTB)against Pb(Ⅱ)and its related mechanisms.The results showed that both MAMB-1 and NM-AMB-1 could significantly detoxify Pb(Ⅱ)-induced cytotoxicity.When the OD565 of bacteria was1,M-AMB-1 and NM-AMB-1 increased the cell viability induced by Pb pretreatment for 6 h by 2.17 and 2.25-fold,respectively.Moreover,a series of biological endpoints including cell apoptosis,cell membrane damage,reactive oxygen species generation,and DNA damage confirmed the efficient antagonism of M-AMB-1 and NMAMB-1 against Pb(Ⅱ)-induced cytotoxicity and genotoxicity.Both types of AMB-1 antagonized the toxicity of Pb(Ⅱ)by enriching Pb(Ⅱ)and reducing the cellular Pb(Ⅱ)accumulation.Interestingly,the presence or absence of magnetosomes determined the distinct enrichment pathways of Pb(Ⅱ)in AMB-1:M-AMB-1 primarily mediated surface adsorption of Pb(Ⅱ),whereas massive Pb(Ⅱ)could be internalized into NM-AMB-1 approximately through the iron-transport system.The different Pb(Ⅱ)enrichment mechanisms probably resulted from the content of iron in bacteria,which competitively inhibited the further uptake of Pb(Ⅱ).This study innovatively revealed the mechanistic differences between M-AMB-1 and NM-AMB-1 in Pb(Ⅱ)enrichment.These findings might not only offer novel intervention strategies for Pb(Ⅱ)poisoning but also expand the application of MTB in the field of environmental health. 展开更多
关键词 Lead Magnetotactic bacteria Detoxification Bioaccumulation
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Transcriptional and epigenetic changes associated with lead exposure in spermatozoa 认领 引用
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作者 Xu Zhang Xiao-Rong Shen +3 位作者 Bin Wu Xue-Mei Wang Hui-Juan Shi Tian-Cheng Zhang 《Asian Journal of Andrology》 SCIE CAS CSCD 2026年第3期297-303,共7页
Lead(Pb)exposure is a risk factor of male infertility,while the transcriptional and epigenetic changes associated with lead exposure in spermatozoa are poorly understood.Our previous findings revealed significant chan... Lead(Pb)exposure is a risk factor of male infertility,while the transcriptional and epigenetic changes associated with lead exposure in spermatozoa are poorly understood.Our previous findings revealed significant changes in DNA methylation of the calcium(Ca)homeostasis pathway of human spermatozoa in men with a blood Pb level over 5µg dl−1,which was associated with decreased sperm motility.In this study,we explored the effects of Pb exposure on expression of differentially methylated genes(DMGs)by analyzing semen samples from six healthy,non-smoking,and non-drinking men(aged 20–40 years).Using methylated DNA immunoprecipitation sequencing(MeDIP-seq)and RNA sequencing(RNA-seq),we compared DNA methylation and RNA abundance patterns between two groups:three men with blood Pb level 0–2.5µg dl−1 and three men with blood Pb level 5–10µg dl−1.Additionally,we experimentally validated the regulatory function of the differentially methylated regions associated with 11 hub genes using dual-luciferase reporter assays.We revealed differences in promoter activity between methylated and unmethylated promoter regions of seven cloned genes,namely calcium voltage-gated channel subunit alpha1 H(CACNA1H),calcium voltage-gated channel subunit alpha1 G(CACNA1G),calcium voltage-gated channel subunit alpha1 I(CACNA1I),calcium/calmodulin dependent protein kinase II gamma(CAMK2G),ATPase sarcoplasmic/endoplasmic reticulum Ca²+transporting 3(ATP2A3),solute carrier family 8 member A2(SLC8A2),and glutamate ionotropic receptor NMDA type subunit 2D(GRIN2D).Our results of Pb exposure-induced expression changes of essential genes associated with the calcium signaling pathway,particularly CACNA1H,SLC8A2,and GRIN2D,in spermatozoa,may be a potential cause of low sperm quality. 展开更多
关键词 calcium homeostasis pathway DNA methylomes lead exposure sperm motility transcriptomes
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Synergistic cell membrane-coated ECL-DNA biosensor for specificity-enhanced drug lead evaluation 认领 引用
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作者 Dan Wu Qi Hu +5 位作者 Qianhui Wu Guoxi Xia Jiabo Wang Yusi Bu Xiaoyu Xie Sicen Wang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期438-451,共14页
Cell membrane coating technology has recently emerged as a promising platform for drug activity assessment due to its unique biointerfacing capabilities.Nevertheless,its integration with conventional detection methods... Cell membrane coating technology has recently emerged as a promising platform for drug activity assessment due to its unique biointerfacing capabilities.Nevertheless,its integration with conventional detection methods such as high performance liquid chromatography(HPLC)and fluorescence probe analysis remains limited by poor specificity and low accuracy,primarily resulting from non-specific adsorption of non-target membrane receptors and interference from background signals.In this study,we presented a collaborative strategy that integrates aptamers with cell membrane coating technology to establish a novel electrochemiluminescence(ECL)-DNA biosensor platform for specifically detecting drug-target receptor interactions.High specificity was achieved through competitive binding between aptamers and drug candidates for membrane receptors,while high accuracy was ensured by employing an ECL detection system incorporating signal cascade amplification and three-dimensional(3D)DNA walkers,enabling reliable performance even with complex biological samples.Using this approach,we demonstrated a linear dynamic range of 1 nmol/L to 2μmol/L for the detection of desloratadine activity,with a limit of detection(LOD)of 0.16 nmol/L.Furthermore,the platform was successfully applied to evaluate the binding activity of eight drugs to angiotensin-converting enzyme 2(ACE2),and their pharmacological activities were further characterized.Overall,this aptamer-cell membrane coating synergistic strategy offered excellent specificity and ultra-high sensitivity,making it a valuable tool for elucidating drug-receptor mechanisms of action and providing a robust reference for preclinical drug activity evaluation. 展开更多
关键词 Cell membrane coating technology Angiotensin-converting enzyme 2 Drug lead evaluation Electrochemiluminescence biosensor Aptamer
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Weed Species Associated with Cacao Cultivation Exhibiting Phytoremediation Potential for Cadmium and Lead:A Study Based on Bioconcentration and Translocation Factors 认领 引用
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作者 Lorena E.Romero-Chávez Emilee Calero-Rios +5 位作者 Uriel Aldava-Pardave Elvis Ottos-Díaz Noelito Salgado-Veramendi Eldhy S.Huerto-Pajuelo Carolina Ibarra-Porras Richard A.Solórzano-Acosta 《Phyton-International Journal of Experimental Botany》 SCIE 2026年第6期346-365,共20页
The exploration and identification of spontaneous weed species in heavy metal–contaminated soils represent a relevant approach for understanding the role and their potential application in phytoremediation.In cacao c... The exploration and identification of spontaneous weed species in heavy metal–contaminated soils represent a relevant approach for understanding the role and their potential application in phytoremediation.In cacao cultivation,cadmium contamination poses a significant risk due to the restrictions established for soils and cacao-derived products,thereby threatening productive sustainability and export viability.The objective of this study was to identify weed species associated with cacao cultivation exhibiting accumulation patterns and phytoremediation potential for Cd and Pb,through the assessment of biomass production and the bioconcentration factor(BCF)and translocation factor(TF),in natural conditions.Soil samples were collected from seven cacao-growing zones,and the site with the highest Cd concentration(1.65 mg kg−1)was selected,where ten dominant weed species were identified and evaluated.Significant interspecific differences were observed in biomass production and in Cd and Pb concentrations(p<0.05).Talinum paniculatum exhibited the highest total biomass(6.15 g)and the highest TF for Cd,whereas Cyperus aggregatus showed the greatest total Cd accumulation(2.68 mg kg−1).BCF and TF values enabled the identification of species with accumulation patterns consistent with Cd phytoextraction(T.paniculatum,C.aggregatus,Pseudelephantopus spiralis,Bidens riparia,Euphorbia heterophylla,and Malvastrum coromandelianum)and with phytostabilization(Ocimum campechianum).For Pb the observed patterns were consistent with potential phytoextractive behavior in B.riparia,P.spiralis,E.heterophylla,Hilleria latifolia,and Acalypha stachyura.Although these results do not constitute functional evidence of remediation,they describe heavy metal accumulation and translocation patterns in native weed species,providing a technical basis for the design of future experimental trials aimed at the sustainable remediation of contaminated soils. 展开更多
关键词 Spontaneousweeds cadmium lead plant biomass bioconcentration factor translocation factor rhizosphere
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Hypersonic Flow over V-Shaped Leading Edges:A Review of Shock Interactions and Aerodynamic Loads 认领 引用
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作者 Xinyue Dong Wei Zhao +4 位作者 Jingying Wang Shiyue Zhang Yue Zhou Xinglian Yang Chunhian Lee 《Fluid Dynamics & Materials Processing》 EI 2026年第1期26-44,共19页
For hypersonic air-breathing vehicles,the V-shaped leading edges(VSLEs)of supersonic combustion ramjet(scramjet)inlets experience complex shock interactions and intense aerodynamic loads.This paper provides a comprehe... For hypersonic air-breathing vehicles,the V-shaped leading edges(VSLEs)of supersonic combustion ramjet(scramjet)inlets experience complex shock interactions and intense aerodynamic loads.This paper provides a comprehensive review of flow characteristics at the crotch of VSLEs,with particular focus on the transition of shock interaction types and the variation of wall heat flux under different freestream Mach numbers and geometric configurations.The mechanisms governing shock transition,unsteady oscillations,hysteresis,and three-dimensional effects in VSLE flows are first examined.Subsequently,thermal protection strategies aimed at mitigating extreme heating loads are reviewed,emphasizing their relevance to practical engineering applications.Special attention is given to recent studies addressing thermochemical nonequilibrium effects on VSLE shock interactions,and the limitations of current research are critically assessed.Finally,perspectives for future investigations into hypersonic VSLE shock interactions are outlined,highlighting opportunities for advancing design and thermal management strategies. 展开更多
关键词 V-shaped leading edges shock interaction scramjet thermochemical nonequilibrium aerodynamic heating
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Detection of Arctic Leads Based on FY-3D/MERSI-Ⅱ 认领 引用
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作者 CHAO Tong LI Lele CHEN Haihua 《Journal of Ocean University of China》 SCIE CAS CSCD 2026年第4期1313-1330,共18页
As a critical channel for sea-air energy exchange,the precise detection of Arctic leads is essential for understanding the mechanism of climate change and ensuring the safety of Arctic navigation.In this study,we addr... As a critical channel for sea-air energy exchange,the precise detection of Arctic leads is essential for understanding the mechanism of climate change and ensuring the safety of Arctic navigation.In this study,we address the limitations of existing remote sensing products,such as insufficient spatial resolution,high sensitivity to cloud interference,and limited adaptability of detection methods by leveraging the visible and thermal infrared multispectral synergistic observation capability of China’s FY-3D/MERSI-Ⅱ.We introduce the visible channel of FY-3D/MERSI-Ⅱ,constructing a synergistic observation system with the thermal infrared channel to overcome the inherent limitations of single-channel observation,addressing cloud interference in Arctic lead detection by establishing a pixel credibility model,and propose an adaptive iterative fuzzy classification(AIFC)method to effectively surmount the technical bottleneck of poor adaptability of traditional threshold methods when applied to complex underlying surfaces.The results indicate that from April 1 to 30,2021,the proposed method effectively suppresses false alarms due to thin cloud cover through the incorporation of pixel credibility,thereby achieving a lower false detection rate than the Willmes lead product.The average probability of lead detection from this method reaches 0.912±0.041,which is 10.4%higher than that of the iterative threshold method,and the probability of background detection is increased to 0.987±0.035.In addition,the average precision rate reaches 0.872,and the F1-score reaches 0.913.The proposed method effectively identifies leads of varying scales across different Arctic regions,demonstrating that the combination of multispectral synergy and fuzzy classification significantly enhances the detection accuracy of Arctic leads. 展开更多
关键词 Arctic leads FY-3D/MERSI-Ⅱ fuzzy classification multiscale fusion
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Urinary Arsenic,Lead,and Their Joint Effects on Hypotension in Children and Adolescents Aged 8-17 Years:A Cross-Sectional Analysis of NHANES 2007-2018 认领 引用
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作者 Wen Duan Jie Liu +2 位作者 Xinpei Luo Caixia Liu Zhui Ke 《Asia Pacific Journal of Clinical Medical Research》 2026年第2期47-59,共13页
Background:Evidence on the joint effects of arsenic and lead exposure on pediatric hypotension is limited.The modifying roles of age,sex,and body weight in this association remain unclear.Methods:Using NHANES 2007-201... Background:Evidence on the joint effects of arsenic and lead exposure on pediatric hypotension is limited.The modifying roles of age,sex,and body weight in this association remain unclear.Methods:Using NHANES 2007-2018 data(2,043 adolescents aged 8-17y),we employed survey-weighted logistic regression(hypotension risk),weighted linear regression(blood pressure percentiles),and Weighted Quantile Sum regression(joint effects).Results:In weighted logistic regres-sion,Model 1(adjusted for age,sex,race)showed arsenic fourth quartile increased hypotension risk(OR=1.73,95%CI:1.132.64,P=0.01).After full adjustment(Model 2:Model 1+BMI,income,sodium,calories,household size),this risk remained significant(OR=1.63,95%CI:1.03-2.5,P=0.04)with a significant trend(P-trend=0.04).For lead,Model I fourth quartile risk(OR=1.66,95%CI:1.05-2.64,P=0.03)shifted to third quartile significance in Model 2(OR=1.54,95%CI:1.04-2.28,P=0.03).Linear regression revealed arsenic third quartile significantly reduced diastolic blood pressure percentile in both Model 1(β=6.20,95%CI:-10.92-1.47,P=0.01)and Model 2(β=5.75,95%CI:-10.41-1.09,P=0.02).The Weighted Quantile Sum(WQS)index showed consistent risk in the main model(OR=1.21,95%CI:1.03-1.42,P=0.02).Stratified analyses(Model 2 based)showed males had higher lead sensitivity Q2(OR=2.01,P=0.005),normal weight individuals had strongest associations lead Q4(OR=2.14,P=0.02):arsenic Q4(OR=2.04,P=0.02)and early puberty(11-13 years)exhibited peak lead risk Q3(OR=2.45,P=0.005).Conclusion:Arsenic and lead additively increase pediatric hypotension risk,with effects modified by sex,BMI,and pubertal stage.Normal-weight males in early puberty are the most vulnerable subgroup. 展开更多
关键词 NHANES Hypotension Heavy Metals Lead Arsenic
Colloidal synthesis of lead chalcogenide/lead chalcohalide core/shell nanostructures and structural evolution 认领 引用 被引量：2
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作者 Yang Liu Kunyuan Lu +11 位作者 Yujie Zhu Xudong Hu Yusheng Li Guozheng Shi Xingyu Zhou Lin Yuan Xiang Sun Xiaobo Ding Irfan Ullah Muhammad Qing Shen Zeke Liu Wanli Ma 《Journal of Semiconductors》 EI CAS CSCD 2025年第4期38-44,共7页
Lead chalcohalides(PbYX,X=Cl,Br,I;Y=S,Se)is an extension of the classic Pb chalcogenides(PbY).Constructing the heterogeneous integration with PbYX and PbY material systems makes it possible to achieve significantly im... Lead chalcohalides(PbYX,X=Cl,Br,I;Y=S,Se)is an extension of the classic Pb chalcogenides(PbY).Constructing the heterogeneous integration with PbYX and PbY material systems makes it possible to achieve significantly improved optoelectronic performance.In this work,we studied the effect of introducing halogen precursors on the structure of classical PbS nanocrystals(NCs)during the synthesis process and realized the preparation of PbS/Pb3S2X2 core/shell structure for the first time.The core/shell structure can effectively improve their optical properties.Furthermore,our approach enables the synthesis of Pb3S2Br2 that had not yet been reported.Our results not only provide valuable insights into the heterogeneous integration of PbYX and PbY materials to elevate material properties but also provide an effective method for further expanding the preparation of PbYX material systems. 展开更多
关键词 lead chalcohalides lead chalcogenides PbS nanocrystal core/shell structure Pb3S2X2nanocrystal
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Shipbuilding Sector Maintains Global Lead in 2025 认领 引用
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《ChinAfrica》 2026年第3期52-53,共2页
China’s shipbuilding industry maintained the world’s largest market share in terms of three major indicators for the 16th consecutive year in 2025,according to data released by the Ministry of Industry and Informati... China’s shipbuilding industry maintained the world’s largest market share in terms of three major indicators for the 16th consecutive year in 2025,according to data released by the Ministry of Industry and Information Technology on 1 February. 展开更多
关键词 global lead indicators China shipbuilding market share
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The Recovery of PGMs from Spent Automotive Exhaust Catalysts by Lead Slag 认领 引用 被引量：1
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作者 YAN Jisen ZHANG Liao +5 位作者 MAO Shuaidong WANG Zihan PENG Yinli XIE Fang HUA Xijin ZHANG Baojing 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2025年第3期871-879,共9页
This paper presented a novel and environmentally friendly approach for recovering platinum group metals(PGMs)from spent automotive exhaust catalysts.The study employed lead slag and waste graphite electrodes as raw ma... This paper presented a novel and environmentally friendly approach for recovering platinum group metals(PGMs)from spent automotive exhaust catalysts.The study employed lead slag and waste graphite electrodes as raw materials,incorporating CaO as an additive to fine-tune the slag's viscosity and density.By reducing FeO in the lead slag using waste graphite electrodes,pure Fe was obtained,effectively trapping the PGMs from the exhausted catalysts.The study explored the effects of reductant addition,trapping duration,slag basicity,and trapping temperature on the recovery rate of PGMs.The results indicated that a maximum recovery rate of 97.86%was achieved when the reductant was added at 1.5 times the theoretical amount,with a trapping duration of 60 minutes,a slag basicity of 0.7,and a trapping temperature of 1600℃.This research offered a greener pathway for the recovery of PGMs from spent automotive exhaust catalysts. 展开更多
关键词 PGMs lead slag recovery spent automotive exhaust catalysts
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Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection 认领 引用
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作者 Weimin Liang Jindi Lu +10 位作者 Ping Yu Meiqun Cai Danni Xie Xini Chen Xi Zhang Lingmin Tian Liyan Yan Wenxun Lan Zhongqiu Liu Xuefeng Zhou Lan Tang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第5期614-629,共16页
This study investigates the pharmacokinetics and metabolic characteristics of three marinederived piericidins as potential drug leads for kidney disease:piericidin A(PA)and its two glycosides(GPAs),glucopiericidin A(G... This study investigates the pharmacokinetics and metabolic characteristics of three marinederived piericidins as potential drug leads for kidney disease:piericidin A(PA)and its two glycosides(GPAs),glucopiericidin A(GPA)and 13-hydroxyglucopiericidin A(13-OH-GPA).The research aims to facilitate lead selection and optimization for developing a viable preclinical candidate.Rapid absorption of PA and GPAs in mice was observed,characterized by short half-lives and low bioavailability.Glycosides and hydroxyl groups significantly enhanced the absorption rate(13-OH-GPA>GPA>PA).PA and GPAs exhibited metabolic instability in liver microsomes due to Cytochrome P450 enzymes(CYPs)and uridine diphosphoglucuronosyl transferases(UGTs).Glucuronidation emerged as the primary metabolic pathway,with UGT1A7,UGT1A8,UGT1A9,and UGT1A10 demonstrating high elimination rates(30%-70%)for PA and GPAs.This rapid glucuronidation may contribute to the low bioavailability of GPAs.Despite its low bioavailability(2.69%),13-OH-GPA showed higher kidney distribution(19.8%)compared to PA(10.0%)and GPA(7.3%),suggesting enhanced biological efficacy in kidney diseases.Modifying the C-13 hydroxyl group appears to be a promising approach to improve bioavailability.In conclusion,this study provides valuable metabolic insights for the development and optimization of marine-derived piericidins as potential drug leads for kidney disease. 展开更多
关键词 Piericidin glycosides Pharmacokinetics Metabolism Drug evaluation Drug lead selection
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Tracing Metal Sources of Geogas with Lead Isotopes:A Case Study on the Bairendaba Silver-polymetallic Deposit,Inner Mongolia 认领 引用
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作者 FAN Huihu ZUO Libo +4 位作者 WAN Wei WANG Mingqi QI Fuyong GAO Yuyan ZHANG Bimin 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2025年第6期1776-1787,共12页
Geogas survey is an unconventional geochemical prospecting method that has proven particularly effective in exploring concealed ore deposits.However,its application in covered areas has been questioned due to the lack... Geogas survey is an unconventional geochemical prospecting method that has proven particularly effective in exploring concealed ore deposits.However,its application in covered areas has been questioned due to the lack of a confirmed geogas formation mechanism.Investigating the sources of geogas anomalies can help clarify this mechanism.This study focuses on the Bairendaba silver-polymetallic deposit,located in a grassland-covered area.Tracer research was conducted on lead isotope compositions in the mining area by analyzing various solid media(soil,rocks,ores)and geogas samples.The results revealed considerable differences in lead isotope compositions between background geogas samples and solid media.Furthermore,the lead isotope compositions of anomalous geogas samples differed markedly from those of background samples.These anomalous samples are located closer to the ore body,suggesting that ore-derived lead is incorporated into the geogas.The anomalous lead in geogas is inferred to originate from deep,concealed ore bodies.This study provides a theoretical basis for applying geogas surveys in mineral exploration within covered terrains. 展开更多
关键词 geogas survey lead isotope metal sources of geogas Bairendaba silver-polymetallic deposit
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