The destabilization of overhanging rock is a dangerous geological problem.In this study,a generalized model of typical overhanging cliffs from the Three Gorges Reservoir area in China with different fracture angles,fr...The destabilization of overhanging rock is a dangerous geological problem.In this study,a generalized model of typical overhanging cliffs from the Three Gorges Reservoir area in China with different fracture angles,fracture lengths,and free surface depths is constructed to investigate the cracking and deformation behavior of overhanging rocks.Laboratory tests and deformation field monitoring using the digital image correlation(DIC)method are performed on these specimens to reproduce the destabilization and failure process of overhanging rock under external loading.The influence of peak load is found to be the most sensitive to the fracture length,followed by the free surface depth,and to be the least sensitive to the fracture angle.The DIC-based strain fields reveal that the fracture angle and free surface depth significantly alter the crack propagation paths,whereas the influence of the fracture length is weaker.These parameters also affect the crack initiation time.The relative displacement evolution characteristics indicate that fracture angle,fracture length,and free surface depth affect the shape and size of the rotating block,the rotation center,and the rotation pivot point and degree,respectively.The grayscale characteristic evolution trends are similar for all examined overhanging rock specimens.The evolution of the grayscale indices based on DIC can be divided into high-frequency oscillation,smooth decline(or smooth downward concavity),and stable development stages.Furthermore,the multistage properties of the indices can be used to identify the fracture state of overhanging rocks,providing a theoretical basis for graded early warning of rockfall disasters.展开更多
The characteristics of USB data acquisition system NI cDAQ and its control software LabVIEW are briefed.The methods for controlling GDS pressure and volume controller by LabVIEW through serial port communication are p...The characteristics of USB data acquisition system NI cDAQ and its control software LabVIEW are briefed.The methods for controlling GDS pressure and volume controller by LabVIEW through serial port communication are presented.A practical data sharing method among geotechnical testing systems is illustrated.As an application case on a modified conventional soil triaxial testing system,the automatic triaxial testing system is designed by LabVIEW.Based on the control panel,the cell pressure and back pressure can be controlled independently and the testing data can be recorded automatically.展开更多
900 abusers were tested for the presence of drug abuse and coronavirus disease.In the early stage,the throat and noise samples of these patients were examined by polymerase chain reaction(PCR).The mean age of the stud...900 abusers were tested for the presence of drug abuse and coronavirus disease.In the early stage,the throat and noise samples of these patients were examined by polymerase chain reaction(PCR).The mean age of the study group is 42±23.Hematological and serological examinations were performed on 131 patients.All data were analyzed by t-test and one-way analysis of variance(ANOVA).Therefore,P<0.05 is considered as the significance of the test results.The results showed that 131 patients in the study group had positive results of PCR tests and nearby they had Covid-19.Approximately 90%of patients with coronavirus disease showed positive serological tests and lymphopenic condition.All of urine or blood samples in the 131 patients were positive for the presence of abuse drugs.C-reactive protein(CRP)is one of important serologic test that detected on these patients.This study showed the importance of molecular genetics test such as PCR and also hematology and serology tests in distinguish of coronavirus diseases.展开更多
Objective:Perform a literary review of the interference in the results of biochemical laboratory tests caused by antihypertensive drugs.Methods:This is a review of the scientific literature with descriptive research p...Objective:Perform a literary review of the interference in the results of biochemical laboratory tests caused by antihypertensive drugs.Methods:This is a review of the scientific literature with descriptive research performed according to the PRISMA model using the databases PUBMED,SCIELO,MEDLINE,LILACS,and searches of Brazilian Ministry of Health and Federal Pharmacy Council publications,reagent kits and package inserts approved by ANVISA.Literature and papers in Portuguese and English were selected,prioritizing the years 2010 to 2020.Results:The diuretic class of antihypertensive drugs causes decreases glucose tolerance,thus resulting in an increase in triglycerides.In long-term use,the drug captopril can increase serum levels of potassium,creatine kinase and decreases blood sodium.Methyldopa causes an increase in AST levels.Propranolol is associated with an increase in triglyceride levels and a decrease in HDL and glucose levels.The constant use of losartan results in an increase in HDL,a decrease in uric acid levels and a slight and transient increase in transaminases.In the Gold Analisa,Bioclin and Labtest reagent kits,most of the alterations occur due to the increase in levels of serum biomarkers according to the class of the antihypertensive drug.Conclusions:Biochemical alterations in serum can result in false-positive or false-negative reports,since it can be observed that most of the dosages caused increases due to the physiological effect of the drugs.The antihypertensive drugs that showed the highest incidence of interference were captopril,atenolol,losartan and propranolol.展开更多
In this study, five hundred urine samples and five hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples ...In this study, five hundred urine samples and five hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples of addicts in clinics of welfare organization, during detoxification treatment or maintenance treatment were screened for abuse drugs presence. The all of samples were tested through as a view of clinical laboratory methods. Age ranges of female patients were 35 ~ 15 and age range of males patients were 45 ~ 15. All patients filled questionnaire and satisfy forms too. First, all fresh urine and blood samples were examined to confirm presence drugs abuses, depend on their addiction and treatment, so all samples were confirmed by two tests. Then they were examined to other clinical laboratory tests. All data were analyzed by t-test and were Anova one way and two ways of Anova Turkey, and p 〈 0.05 was considered significant. The p-value of this study was p = 0.0001. The results of this study were showed that 4% of abusers had mild increase in hematocrite level and 2% of narcotic drugs abusers had mild lower level of blood sugars than normal range and 4% of participants had increase liver enzymes such ALT (alanine transferase), AST (aspartat transferase), ALP (alkaline phosphatease) and 1% of them had renal failure. Although blood level BUN (blood urea nitrogen) and creatinin were examined to evaluation of their renal failure .The results in Tabriz/Iran undrevision of welfare organization clinics were approximately showed that positive results of addiction are in each of urine and blood samples. Because some of abusers directly consumed full long time agonist or partial agonists' drugs such as methadone and buprenorphine for their maintenance therapy in clinics. Also doing test on blood samples has high importance in distinguishing and confirmation of drugs abuse in samples. Also in this study we conclude that among all drug analytical methods the cheapest and easiest test to screening opioids and other abuse drugs in urine and blood samples is strip test for rapid diagnosis, also tests on blood samples have high importance as a view point of accuracy to distinguishing of drugs abuse, and serum levels of some other parameters showed all abusers patients situation such as liver and renal dysfimction through clinical laboratory tests.展开更多
Replacing cement clinker with solid residue is a highly promising decarbonization strategy in soil improvement.Waste clay was improved by desulfurized gypsum and carbide slag using eco-friendly low-temperature hydroth...Replacing cement clinker with solid residue is a highly promising decarbonization strategy in soil improvement.Waste clay was improved by desulfurized gypsum and carbide slag using eco-friendly low-temperature hydrothermal solidification technology in this study.The compressive strength of the hydrothermally solidified waste clay was investigated,and four hybrid prediction models(PSO-RF,PSO-GPR,PSO-GBR,and PSO-AdaBoost)were developed to predict its compressive strength.The results showed that the strength of the hydrothermally solidified waste clay significantly increased but then decreased when the Ca/Si ratio exceeded 0.8–0.9.Water has a dual effect on the strength of hydrothermally solidified waste clay,with an optimum range of approximately 10%–20%.Among the strength prediction models developed for hydrothermally solidified waste clay,the optimization performance and prediction accuracy of PSO-GBR are superior,and the UCS prediction results of other studies with various precursor types have been verified.SHapley Additive exPlanation(SHAP)analysis of the PSO-GBR model revealed that the pressed dry density contributes most significantly to the compressive strength of hydrothermally solidified waste clay,followed by the autoclave temperature,water content,Ca/Si ratio,and autoclave temperature.The impact of each input feature of the prediction model is consistent with the experimental results and previous studies.展开更多
Understanding the slip-style evolution of tectonic faults is important for exploring the earthquake mechanisms. Toreveal the fault slip characteristics under a complex stress state, we conducted a series of laboratory...Understanding the slip-style evolution of tectonic faults is important for exploring the earthquake mechanisms. Toreveal the fault slip characteristics under a complex stress state, we conducted a series of laboratory friction testson saw-cut granite joint surfaces. The effects of load point velocity and normal stress disturbances were investigated. Based on laboratory observations, a one-dimensional Spring-Block model was developed to interpret thefrictional behavior. Under constant normal stress, the simulated fault (granite joint) exhibits a regular stick-slipphenomenon at different load point velocities with stable recurrence intervals and stress drop magnitudes.Under cyclic normal stress, when the load point velocity is slow, stick-slip events occur only after 4-5 cycles ofnormal stress loading. When the load point velocity is large, due to the rapid sliding of the joint interface, onenormal stress cycle can lead to 4-5 stick-slip events. We find that the cyclic normal stress weakens the joint shearstrength when the load point velocity is slow and improves the strength when the velocity is fast. There is acritical value of load point velocity for resonance where the stick-slip occurrence timespan is identical to thenormal stress cyclic period. This work sheds light on the frictional evolution of tectonic faults during the seismiccycles influenced by a complex stress state.展开更多
To address the scientific challenges in laboratory shock testing of large-inertia and large-scale marine structural components,particularly those used in deep-sea naval environments,a pneumatic-hydraulic shock testing...To address the scientific challenges in laboratory shock testing of large-inertia and large-scale marine structural components,particularly those used in deep-sea naval environments,a pneumatic-hydraulic shock testing apparatus(PHSTA)has been developed.In contrast to conventional drop-weight,pendulum,or explosion-based shock simulators that rely on localized collisions or rigid impacts,the proposed PHSTA employs a pneumatic-hydraulic spring mechanism to provide controllable,repeatable,and tunable shock responses.A comprehensive theoretical framework was developed,including dynamic modeling of the PHSTA,energy storage analysis,and closed-form expressions for equivalent stiffness and acceleration characteristics.The effects of gas precharge pressures po and loading pressuresΔp on the stored energy E,shock acceleration,and the system's dynamic characteristics-in particular the natural frequency and damping ratio-were quantitatively analyzed using AMESim.Experimental validation was conducted on a prototype PHSTA,and the measured shock responses demonstrated the validity of the proposed model,showing good agreement with both the theoretical analysis and simulation results.At p0=10 MPa,the peak acceleration increased by 24.7%compared to p0=13 MPa,closely matching the simulated result of 23.3%.The developed PHSTA offers a novel approach for simulating marine shock environments under laboratory conditions and provides a robust platform for evaluating the shock resistance of offshore and naval structural components.展开更多
Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating s...Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating slab track (FST), low frequency vibration tests on an FST in an underground laboratory at Beijing Jiaotong University were carried out. The FST and an unbalanced shaker SBZ30 for dynamic simulation were designed for use in low frequency vibration experiments. Vibration measurements were performed on the bogie of the unbalanced shaker, the rail, the slab, the tunnel invert, the tunnel wall, the tunnel apex, and on the ground surface at distances varying from 0 to 80 m from the track. Measurements were also made on several floors of an adjacent building. Detailed results of low frequency vibration tests were reported. The attenuation of low frequency vibrations with the distance from the track was presented, as well as the responses of different floors of the building. The experimental results could be regarded as a reference for developing methods to control low frequency vibrations and for adopting countermeasures.展开更多
Broken coal and rock(BCR)are an important component medium of the caving zone in the goaf(or gob),as well as the main filling material of fault fracture zone and collapse column.The compaction seepage characteristics ...Broken coal and rock(BCR)are an important component medium of the caving zone in the goaf(or gob),as well as the main filling material of fault fracture zone and collapse column.The compaction seepage characteristics of BCR directly affect the safe and efficient mining of coal mines.Thus,numerous laboratory studies have focused on the compaction seepage characteristics of BCR.This paper first outlines the engineering problems involved in the BCR during coal mining including the air leakage,the spontaneous combustion,the gas drainage,and the un-derground reservoirs in the goaf.Water inrush related to tectonics such as faults and collapse columns and surface subsidence related to coal gangue filling and mining also involve the compaction seepage characteristics of BCR.Based on the field problems of BCR,many attempts have been made to mimic field environments in laboratory tests.The experimental equipment(cavity size and shape,acoustic emission,CT,etc.)and experimental design for the BCR were firstly reviewed.The main objects of laboratory analysis can be divided into compression tests and seepage test.During the compaction test,the main research focuses on the bearing deformation characteristics(stress-strain curve),pore evolution characteristics,and re-crushing characteristics of BCR.The seepage test mainly uses gas or water as the main medium to study the evolution characteristics of permeability under different compaction stress conditions.In the laboratory tests,factors such as the type of coal and rock mass,particle size,particle shape,water pressure,temperature,and stress path are usually considered.The lateral compression test of BCR can be divided into three stages,including the self-adjustment stage,the broken stage,and the elastic stage or stable stage.At each stage,stress,deformation,porosity,energy,particle size and breakage rate all have their own characteristics.Seepage test regarding the water permeability experiment of BCR is actually belong to variable mass seepage.While the experimental test still focuses on the influence of stress on the pore structure of BCR in terms of gas permeability.Finally,future laboratory tests focus on the BCR related coal mining including scaling up,long term loading and water immersion,mining stress path matching were discussed.展开更多
Underground mine pillars provide natural stability to the mine area,allowing safe operations for workers and machinery.Extensive prior research has been conducted to understand pillar failure mechanics and design safe...Underground mine pillars provide natural stability to the mine area,allowing safe operations for workers and machinery.Extensive prior research has been conducted to understand pillar failure mechanics and design safe pillar layouts.However,limited studies(mostly based on empirical field observation and small-scale laboratory tests)have considered pillar-support interactions under monotonic loading conditions for the design of pillar-support systems.This study used a series of large-scale laboratory compression tests on porous limestone blocks to analyze rock and support behavior at a sufficiently large scale(specimens with edge length of 0.5 m)for incorporation of actual support elements,with consideration of different w/h ratios.Both unsupported and supported(grouted rebar rockbolt and wire mesh)tests were conducted,and the surface deformations of the specimens were monitored using three-dimensional(3D)digital image correlation(DIC).Rockbolts instrumented with distributed fiber optic strain sensors were used to study rockbolt strain distribution,load mobilization,and localized deformation at different w/h ratios.Both axial and bending strains were observed in the rockbolts,which became more prominent in the post-peak region of the stress-strain curve.展开更多
There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver dama...There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver damage, fibrosis or regenerative process, but this point is not always shared. Actually, balancing the need for diagnosis, prognostic evaluation and therapy response of liver disease with a good cost/benefit ratio is very difficult. New tests are probably not needed but the aim should be for better utilization of existing tests to contain the increasing cost of health care.展开更多
Large-diameter shield tunneling in composite strata presents significant challenges due to the heterogeneous mechanical properties,posing substantial risks to excavation safety.Existing research,however,provides limit...Large-diameter shield tunneling in composite strata presents significant challenges due to the heterogeneous mechanical properties,posing substantial risks to excavation safety.Existing research,however,provides limited insights into how specific layer configurations influence soil strength,failure mechanisms,and the soil arching effect.This study aims to bridge these knowledge gaps by systematically investigating the mechanical behaviors of sand–clay and sand–pebble composites,as well as their excavation-induced responses.Methodologically,we integrate laboratory triaxial tests on reconstituted composite specimens with 3-dimensional(3D)finite element simulations of the tunneling process.Key contributions of this work include:1)the identification of a critical clay layer thickness(20–40 mm)that governs the transition from interfacial slippage to bulging failure in sand–clay composites;2)the quantification of a progressive strength reduction(up to 14.52%)in sand–pebble composites as the sand layer shifts downward;and 3)a novel comparative analysis using a soil stress coefficient method,which reveals a more extensive destruction zone and a more fragile soil arching effect in sand–pebble strata,thereby indicating an elevated risk of collapse.These findings provide crucial insights into the performance of large-diameter shield tunnels in complex geological conditions and offer guidance for safer design and operational control.展开更多
Despite the unique properties of diatomite,relatively few studies have focused on its geotechnical engineering characteristics,especially those investigating the engineering performance of tunnel foundation pile treat...Despite the unique properties of diatomite,relatively few studies have focused on its geotechnical engineering characteristics,especially those investigating the engineering performance of tunnel foundation pile treatment technologies that account for the creep behavior of diatomite.This study is grounded on the Feifengshan Tunnel Project,a key component of the Hangzhou-Shaoxing-Taizhou High-Speed Railway.To address the geotechnical challenges of this project,the creep deformation behavior of diatomite under different saturation levels was investigated by combining laboratory creep tests and numerical simulations.Subsequently,a comparative analysis was conducted on the long-term deformation of tunnel foundations(LTDTF)in diatomite strata,with consideration of different reinforcement schemes.The findings reveal that under the same creep stress levels,the creep deformation of diatomite first decreases and then increases as saturation rises.Creep parameters obtained through the inversion of field monitoring and laboratory test data are more consistent with practical engineering conditions.The miniature steel pipe pile(MSPP)reinforcement technique improves the load-bearing capacity of tunnel foundations in diatomite strata.For tunnel foundations treated with MSPP,the LTDTF decreases by 70.6%in the 100th year after the completion of the secondary support construction.Furthermore,increasing the length(0-8 m)or diameter(0-150 mm)of MSPP can effectively control the magnitude and range of surrounding rock deformation at three key locations:the tunnel foundation(Point A),the horizontal observation line(Line B-C),and the vertical observation line(Line A-D).The findings provide crucial insights and a practical methodology for predicting and controlling long-term deformation in tunnel projects in diatomite strata.展开更多
A 47-year-old female presented with the chief complaint of dull pain in right upper quadrant of abdomen for 10 days without jaundice.Routine laboratory tests were as follows,liver function tests showed an alanine amin...A 47-year-old female presented with the chief complaint of dull pain in right upper quadrant of abdomen for 10 days without jaundice.Routine laboratory tests were as follows,liver function tests showed an alanine aminotransferase(ALT)level of 49 U/L(normal range,15-40 U/L),an aspartate aminotransferase(AST)level of 96 U/L(normal range,15-40 U/L),a gamma glutamyl transpeptidase(GGT)level of 164 U/L(normal range,10-60 U/L),a total bilirubin(TBil)level of 23.4μmol/L(normal range,1.7-13.7µmol/L).展开更多
The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the p...The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the pavement structure increases the load-carrying capacity of unbound pavement layers by providing lateral restraint,improving vertical stress distribution,and enhancing bearing capacity.Such reinforcement typically aims to either improve the service life of pavements or achieve equivalent performance with a reduced granular cover.Previous and ongoing research quantifies geosynthetic performance in pavement reinforcement using various testing methods.Among these,laboratory model box tests subjected to cyclic loading are pivotal,as they closely replicate real-world traffic conditions.Hence,these studies are essential for understanding how geosynthetics distribute loads and enhance pavement durability.This facilitates the development of optimized geosynthetic design and installation practices,accelerating the loading process to simulate years of traffic wear in a shorter period.This review discusses the improved rutting resistance of unbound pavements reinforced with geosynthetic materials,specifically drawing on data from cyclic plate load tests conducted on laboratory model boxes,as highlighted in the literature.Key variables such as optimum geosynthetic placement,geosynthetic material properties,performance of different geosynthetic materials and the effects of aperture shape and size on rutting resistance are discussed.Furthermore,the review assesses various predictive rutting models,analysing their applicability and accuracy in forecasting the rutting performance of geosynthetic-reinforced unbound pavements.This comprehensive literature review aids pavement engineers and researchers,in guiding the selection and design of geosynthetics to optimize pavement durability and functionality under repetitive traffic loads.展开更多
A series of polyester, cotton, and polyester/cotton blend fabrics were evaluated in a subjective wear. Subjective trial data were correlated with the results of in-house laboratory tests with the regression methods. E...A series of polyester, cotton, and polyester/cotton blend fabrics were evaluated in a subjective wear. Subjective trial data were correlated with the results of in-house laboratory tests with the regression methods. Experimental results indicate that clothing-comfort assessment by human perception provides a sound basis for comparison of apparel garments under combined microclimates and human-activity levels of展开更多
The performance evaluation of gas turbine inlet air filtration systems is commonly based on standardized laboratory testing;however,discrepancies frequently arise between laboratory results and actual operating perfor...The performance evaluation of gas turbine inlet air filtration systems is commonly based on standardized laboratory testing;however,discrepancies frequently arise between laboratory results and actual operating performance.In this study,an on-site testing apparatus was developed to investigate filtration behavior under realistic operating conditions.Field measurements were conducted to analyze pressure loss evolution,particle-size-dependent filtration efficiency,and the influence of environmental parameters,including temperature,humidity,and ambient particulate concentration.Results show that filter pressure loss increased progressively with operational loading,while short-term fluctuations were associated with variations in environmental conditions.Filtration efficiency exhibited an overall increasing tendency with particle size,with minor fluctuations observed at larger particle sizes,and showed limited dependence on pressure loss within the investigated operating range.Correlation analysis indicated that ambient temperature showed a stronger relationship with filtration efficiency compared with humidity and differential pressure,suggesting that environmental conditions play an important role in practical filtration performance.To evaluate the consistency between laboratory certification and field operation,comparative tests were carried out at three representative gas turbine power plants operating under different environmental conditions.Although laboratory and field results demonstrated similar efficiency trends,noticeable quantitative deviations were observed.Correction factors relating laboratory-tested efficiency to field-measured efficiency were determined as 0.82,0.86,and 0.54 for the three sites,respectively.The proposed correction-coefficient approach provides a practical method for translating standardized laboratory performance into realistic operational evaluation,offering useful guidance for filter selection,performance assessment,and operational management of gas turbine inlet air filtration systems.展开更多
In order to study the engineering behaviors of reinforced gabion retaining wall,laboratory model test was carried out.Cyclic load and unload of five levels(0-50,0-100,0-50,0-200 and 0-250 kPa) were imposed.Vertical ea...In order to study the engineering behaviors of reinforced gabion retaining wall,laboratory model test was carried out.Cyclic load and unload of five levels(0-50,0-100,0-50,0-200 and 0-250 kPa) were imposed.Vertical earth pressure,lateral earth pressure,deformation behaviors of reinforcements,potential failure surface and deformation behaviors of wall face were studied.Results show that vertical earth pressure is less than theoretical value,the ratio of vertical earth pressure to theoretical value increases nearly linearly with increasing load,and the correlation coefficient of regression equation is 0.92 for the second layer and 0.79 for the fifth layer.The distribution of lateral earth pressure along the wall back is nonlinear and it is less than theoretical value especially when the load imposed at the top of retaining wall is large.Therefore,reinforced gabion retaining wall will be in great safety when current method is adopted.The deformation behaviors of reinforcements both in the third layer and the fifth layer are single-peak distributions,and the position of the maximum strain is behind that determined by 0.3H(Here H refers to the height of retaining wall) method or Rankine theory.Lateral deformation of wall face increases with increasing load,and the largest lateral deformation occurs in the fourth layer,which lead to a bulging in the middle of wall face.展开更多
The deformation of sea coast or sandy deposits caused by earthquakes can lead to catastrophic damages to various port structures. The volumetric deformation is mainly induced by densification of sand during the dissip...The deformation of sea coast or sandy deposits caused by earthquakes can lead to catastrophic damages to various port structures. The volumetric deformation is mainly induced by densification of sand during the dissipation of excess pore water pressure created by cyclic loading. Based on laboratory test, the reconsolidation volumetric characteristics of saturated sea sand are investigated. The experiments are conducted with a newly developed multi functional triaxial test equipment. Two types of dynamic loads are applied to the samples to clarify different kinds of affecting factors. It is found that the reconsolidation volumetric strain is correlated not only to the excess pore water pressure and the maximum shear strain during the dynamic loading, but also to the effective confining pressure. A new formula is put forward to calculate the volumetric strain during reconssolidation.展开更多
基金supported by the China National Natural Science Foundation(Grant No.42362034)the Applied Basic Research Foundation of Yunnan Province,China(Grant No.202401AS070068).
摘要The destabilization of overhanging rock is a dangerous geological problem.In this study,a generalized model of typical overhanging cliffs from the Three Gorges Reservoir area in China with different fracture angles,fracture lengths,and free surface depths is constructed to investigate the cracking and deformation behavior of overhanging rocks.Laboratory tests and deformation field monitoring using the digital image correlation(DIC)method are performed on these specimens to reproduce the destabilization and failure process of overhanging rock under external loading.The influence of peak load is found to be the most sensitive to the fracture length,followed by the free surface depth,and to be the least sensitive to the fracture angle.The DIC-based strain fields reveal that the fracture angle and free surface depth significantly alter the crack propagation paths,whereas the influence of the fracture length is weaker.These parameters also affect the crack initiation time.The relative displacement evolution characteristics indicate that fracture angle,fracture length,and free surface depth affect the shape and size of the rotating block,the rotation center,and the rotation pivot point and degree,respectively.The grayscale characteristic evolution trends are similar for all examined overhanging rock specimens.The evolution of the grayscale indices based on DIC can be divided into high-frequency oscillation,smooth decline(or smooth downward concavity),and stable development stages.Furthermore,the multistage properties of the indices can be used to identify the fracture state of overhanging rocks,providing a theoretical basis for graded early warning of rockfall disasters.
基金Laboratory and numerical modelling of unsaturated flow in fractured soil and rock(50609012)Fund Proposer:ZHANG Hua.
摘要The characteristics of USB data acquisition system NI cDAQ and its control software LabVIEW are briefed.The methods for controlling GDS pressure and volume controller by LabVIEW through serial port communication are presented.A practical data sharing method among geotechnical testing systems is illustrated.As an application case on a modified conventional soil triaxial testing system,the automatic triaxial testing system is designed by LabVIEW.Based on the control panel,the cell pressure and back pressure can be controlled independently and the testing data can be recorded automatically.
摘要900 abusers were tested for the presence of drug abuse and coronavirus disease.In the early stage,the throat and noise samples of these patients were examined by polymerase chain reaction(PCR).The mean age of the study group is 42±23.Hematological and serological examinations were performed on 131 patients.All data were analyzed by t-test and one-way analysis of variance(ANOVA).Therefore,P<0.05 is considered as the significance of the test results.The results showed that 131 patients in the study group had positive results of PCR tests and nearby they had Covid-19.Approximately 90%of patients with coronavirus disease showed positive serological tests and lymphopenic condition.All of urine or blood samples in the 131 patients were positive for the presence of abuse drugs.C-reactive protein(CRP)is one of important serologic test that detected on these patients.This study showed the importance of molecular genetics test such as PCR and also hematology and serology tests in distinguish of coronavirus diseases.
摘要Objective:Perform a literary review of the interference in the results of biochemical laboratory tests caused by antihypertensive drugs.Methods:This is a review of the scientific literature with descriptive research performed according to the PRISMA model using the databases PUBMED,SCIELO,MEDLINE,LILACS,and searches of Brazilian Ministry of Health and Federal Pharmacy Council publications,reagent kits and package inserts approved by ANVISA.Literature and papers in Portuguese and English were selected,prioritizing the years 2010 to 2020.Results:The diuretic class of antihypertensive drugs causes decreases glucose tolerance,thus resulting in an increase in triglycerides.In long-term use,the drug captopril can increase serum levels of potassium,creatine kinase and decreases blood sodium.Methyldopa causes an increase in AST levels.Propranolol is associated with an increase in triglyceride levels and a decrease in HDL and glucose levels.The constant use of losartan results in an increase in HDL,a decrease in uric acid levels and a slight and transient increase in transaminases.In the Gold Analisa,Bioclin and Labtest reagent kits,most of the alterations occur due to the increase in levels of serum biomarkers according to the class of the antihypertensive drug.Conclusions:Biochemical alterations in serum can result in false-positive or false-negative reports,since it can be observed that most of the dosages caused increases due to the physiological effect of the drugs.The antihypertensive drugs that showed the highest incidence of interference were captopril,atenolol,losartan and propranolol.
摘要In this study, five hundred urine samples and five hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples of addicts in clinics of welfare organization, during detoxification treatment or maintenance treatment were screened for abuse drugs presence. The all of samples were tested through as a view of clinical laboratory methods. Age ranges of female patients were 35 ~ 15 and age range of males patients were 45 ~ 15. All patients filled questionnaire and satisfy forms too. First, all fresh urine and blood samples were examined to confirm presence drugs abuses, depend on their addiction and treatment, so all samples were confirmed by two tests. Then they were examined to other clinical laboratory tests. All data were analyzed by t-test and were Anova one way and two ways of Anova Turkey, and p 〈 0.05 was considered significant. The p-value of this study was p = 0.0001. The results of this study were showed that 4% of abusers had mild increase in hematocrite level and 2% of narcotic drugs abusers had mild lower level of blood sugars than normal range and 4% of participants had increase liver enzymes such ALT (alanine transferase), AST (aspartat transferase), ALP (alkaline phosphatease) and 1% of them had renal failure. Although blood level BUN (blood urea nitrogen) and creatinin were examined to evaluation of their renal failure .The results in Tabriz/Iran undrevision of welfare organization clinics were approximately showed that positive results of addiction are in each of urine and blood samples. Because some of abusers directly consumed full long time agonist or partial agonists' drugs such as methadone and buprenorphine for their maintenance therapy in clinics. Also doing test on blood samples has high importance in distinguishing and confirmation of drugs abuse in samples. Also in this study we conclude that among all drug analytical methods the cheapest and easiest test to screening opioids and other abuse drugs in urine and blood samples is strip test for rapid diagnosis, also tests on blood samples have high importance as a view point of accuracy to distinguishing of drugs abuse, and serum levels of some other parameters showed all abusers patients situation such as liver and renal dysfimction through clinical laboratory tests.
基金supported by the National Natural Science Foundation of China(Grant No.52178327).
摘要Replacing cement clinker with solid residue is a highly promising decarbonization strategy in soil improvement.Waste clay was improved by desulfurized gypsum and carbide slag using eco-friendly low-temperature hydrothermal solidification technology in this study.The compressive strength of the hydrothermally solidified waste clay was investigated,and four hybrid prediction models(PSO-RF,PSO-GPR,PSO-GBR,and PSO-AdaBoost)were developed to predict its compressive strength.The results showed that the strength of the hydrothermally solidified waste clay significantly increased but then decreased when the Ca/Si ratio exceeded 0.8–0.9.Water has a dual effect on the strength of hydrothermally solidified waste clay,with an optimum range of approximately 10%–20%.Among the strength prediction models developed for hydrothermally solidified waste clay,the optimization performance and prediction accuracy of PSO-GBR are superior,and the UCS prediction results of other studies with various precursor types have been verified.SHapley Additive exPlanation(SHAP)analysis of the PSO-GBR model revealed that the pressed dry density contributes most significantly to the compressive strength of hydrothermally solidified waste clay,followed by the autoclave temperature,water content,Ca/Si ratio,and autoclave temperature.The impact of each input feature of the prediction model is consistent with the experimental results and previous studies.
基金funded by the National Natural Science Foundation of China(No.52474122)the Natural Science Foundation of Guangdong Province,China(No.2022A1515240009).
摘要Understanding the slip-style evolution of tectonic faults is important for exploring the earthquake mechanisms. Toreveal the fault slip characteristics under a complex stress state, we conducted a series of laboratory friction testson saw-cut granite joint surfaces. The effects of load point velocity and normal stress disturbances were investigated. Based on laboratory observations, a one-dimensional Spring-Block model was developed to interpret thefrictional behavior. Under constant normal stress, the simulated fault (granite joint) exhibits a regular stick-slipphenomenon at different load point velocities with stable recurrence intervals and stress drop magnitudes.Under cyclic normal stress, when the load point velocity is slow, stick-slip events occur only after 4-5 cycles ofnormal stress loading. When the load point velocity is large, due to the rapid sliding of the joint interface, onenormal stress cycle can lead to 4-5 stick-slip events. We find that the cyclic normal stress weakens the joint shearstrength when the load point velocity is slow and improves the strength when the velocity is fast. There is acritical value of load point velocity for resonance where the stick-slip occurrence timespan is identical to thenormal stress cyclic period. This work sheds light on the frictional evolution of tectonic faults during the seismiccycles influenced by a complex stress state.
基金financial support provided by the Wuhan Second Ship Design and Research Institute,Chinathe technical assistance from the FESTO Pneumatics Center at Huazhong University of Science and Technology,China.
摘要To address the scientific challenges in laboratory shock testing of large-inertia and large-scale marine structural components,particularly those used in deep-sea naval environments,a pneumatic-hydraulic shock testing apparatus(PHSTA)has been developed.In contrast to conventional drop-weight,pendulum,or explosion-based shock simulators that rely on localized collisions or rigid impacts,the proposed PHSTA employs a pneumatic-hydraulic spring mechanism to provide controllable,repeatable,and tunable shock responses.A comprehensive theoretical framework was developed,including dynamic modeling of the PHSTA,energy storage analysis,and closed-form expressions for equivalent stiffness and acceleration characteristics.The effects of gas precharge pressures po and loading pressuresΔp on the stored energy E,shock acceleration,and the system's dynamic characteristics-in particular the natural frequency and damping ratio-were quantitatively analyzed using AMESim.Experimental validation was conducted on a prototype PHSTA,and the measured shock responses demonstrated the validity of the proposed model,showing good agreement with both the theoretical analysis and simulation results.At p0=10 MPa,the peak acceleration increased by 24.7%compared to p0=13 MPa,closely matching the simulated result of 23.3%.The developed PHSTA offers a novel approach for simulating marine shock environments under laboratory conditions and provides a robust platform for evaluating the shock resistance of offshore and naval structural components.
基金Project supported by the National Natural Science Foundation of China (No. 51008017)the Fundamental Research Funds for the Central Universities of China (Nos. 2009JBM074 and 2009JBM075)
摘要Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating slab track (FST), low frequency vibration tests on an FST in an underground laboratory at Beijing Jiaotong University were carried out. The FST and an unbalanced shaker SBZ30 for dynamic simulation were designed for use in low frequency vibration experiments. Vibration measurements were performed on the bogie of the unbalanced shaker, the rail, the slab, the tunnel invert, the tunnel wall, the tunnel apex, and on the ground surface at distances varying from 0 to 80 m from the track. Measurements were also made on several floors of an adjacent building. Detailed results of low frequency vibration tests were reported. The attenuation of low frequency vibrations with the distance from the track was presented, as well as the responses of different floors of the building. The experimental results could be regarded as a reference for developing methods to control low frequency vibrations and for adopting countermeasures.
基金support for this work is provided by the National Key R&D Program of China(2023YFC3012101)the National Natural Science Foundation of China(52104155)+1 种基金the Natural Science Foundation of Beijing(8212032)the Fundamental Research Funds for the Central Universities(2023ZKPYNY03).
摘要Broken coal and rock(BCR)are an important component medium of the caving zone in the goaf(or gob),as well as the main filling material of fault fracture zone and collapse column.The compaction seepage characteristics of BCR directly affect the safe and efficient mining of coal mines.Thus,numerous laboratory studies have focused on the compaction seepage characteristics of BCR.This paper first outlines the engineering problems involved in the BCR during coal mining including the air leakage,the spontaneous combustion,the gas drainage,and the un-derground reservoirs in the goaf.Water inrush related to tectonics such as faults and collapse columns and surface subsidence related to coal gangue filling and mining also involve the compaction seepage characteristics of BCR.Based on the field problems of BCR,many attempts have been made to mimic field environments in laboratory tests.The experimental equipment(cavity size and shape,acoustic emission,CT,etc.)and experimental design for the BCR were firstly reviewed.The main objects of laboratory analysis can be divided into compression tests and seepage test.During the compaction test,the main research focuses on the bearing deformation characteristics(stress-strain curve),pore evolution characteristics,and re-crushing characteristics of BCR.The seepage test mainly uses gas or water as the main medium to study the evolution characteristics of permeability under different compaction stress conditions.In the laboratory tests,factors such as the type of coal and rock mass,particle size,particle shape,water pressure,temperature,and stress path are usually considered.The lateral compression test of BCR can be divided into three stages,including the self-adjustment stage,the broken stage,and the elastic stage or stable stage.At each stage,stress,deformation,porosity,energy,particle size and breakage rate all have their own characteristics.Seepage test regarding the water permeability experiment of BCR is actually belong to variable mass seepage.While the experimental test still focuses on the influence of stress on the pore structure of BCR in terms of gas permeability.Finally,future laboratory tests focus on the BCR related coal mining including scaling up,long term loading and water immersion,mining stress path matching were discussed.
基金the funding support from Alpha Foundation for the Improvement of Mine Safety and Health Inc.(ALPHAFOUNDATION,Grant No.AFC820-52)。
摘要Underground mine pillars provide natural stability to the mine area,allowing safe operations for workers and machinery.Extensive prior research has been conducted to understand pillar failure mechanics and design safe pillar layouts.However,limited studies(mostly based on empirical field observation and small-scale laboratory tests)have considered pillar-support interactions under monotonic loading conditions for the design of pillar-support systems.This study used a series of large-scale laboratory compression tests on porous limestone blocks to analyze rock and support behavior at a sufficiently large scale(specimens with edge length of 0.5 m)for incorporation of actual support elements,with consideration of different w/h ratios.Both unsupported and supported(grouted rebar rockbolt and wire mesh)tests were conducted,and the surface deformations of the specimens were monitored using three-dimensional(3D)digital image correlation(DIC).Rockbolts instrumented with distributed fiber optic strain sensors were used to study rockbolt strain distribution,load mobilization,and localized deformation at different w/h ratios.Both axial and bending strains were observed in the rockbolts,which became more prominent in the post-peak region of the stress-strain curve.
摘要There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver damage, fibrosis or regenerative process, but this point is not always shared. Actually, balancing the need for diagnosis, prognostic evaluation and therapy response of liver disease with a good cost/benefit ratio is very difficult. New tests are probably not needed but the aim should be for better utilization of existing tests to contain the increasing cost of health care.
基金supported by the Shanghai Science and Technology Innovation Program under Grant(No.19DZ1201004).
摘要Large-diameter shield tunneling in composite strata presents significant challenges due to the heterogeneous mechanical properties,posing substantial risks to excavation safety.Existing research,however,provides limited insights into how specific layer configurations influence soil strength,failure mechanisms,and the soil arching effect.This study aims to bridge these knowledge gaps by systematically investigating the mechanical behaviors of sand–clay and sand–pebble composites,as well as their excavation-induced responses.Methodologically,we integrate laboratory triaxial tests on reconstituted composite specimens with 3-dimensional(3D)finite element simulations of the tunneling process.Key contributions of this work include:1)the identification of a critical clay layer thickness(20–40 mm)that governs the transition from interfacial slippage to bulging failure in sand–clay composites;2)the quantification of a progressive strength reduction(up to 14.52%)in sand–pebble composites as the sand layer shifts downward;and 3)a novel comparative analysis using a soil stress coefficient method,which reveals a more extensive destruction zone and a more fragile soil arching effect in sand–pebble strata,thereby indicating an elevated risk of collapse.These findings provide crucial insights into the performance of large-diameter shield tunnels in complex geological conditions and offer guidance for safer design and operational control.
基金supported by the National Natural Science Foundation of China(No.52178395).
摘要Despite the unique properties of diatomite,relatively few studies have focused on its geotechnical engineering characteristics,especially those investigating the engineering performance of tunnel foundation pile treatment technologies that account for the creep behavior of diatomite.This study is grounded on the Feifengshan Tunnel Project,a key component of the Hangzhou-Shaoxing-Taizhou High-Speed Railway.To address the geotechnical challenges of this project,the creep deformation behavior of diatomite under different saturation levels was investigated by combining laboratory creep tests and numerical simulations.Subsequently,a comparative analysis was conducted on the long-term deformation of tunnel foundations(LTDTF)in diatomite strata,with consideration of different reinforcement schemes.The findings reveal that under the same creep stress levels,the creep deformation of diatomite first decreases and then increases as saturation rises.Creep parameters obtained through the inversion of field monitoring and laboratory test data are more consistent with practical engineering conditions.The miniature steel pipe pile(MSPP)reinforcement technique improves the load-bearing capacity of tunnel foundations in diatomite strata.For tunnel foundations treated with MSPP,the LTDTF decreases by 70.6%in the 100th year after the completion of the secondary support construction.Furthermore,increasing the length(0-8 m)or diameter(0-150 mm)of MSPP can effectively control the magnitude and range of surrounding rock deformation at three key locations:the tunnel foundation(Point A),the horizontal observation line(Line B-C),and the vertical observation line(Line A-D).The findings provide crucial insights and a practical methodology for predicting and controlling long-term deformation in tunnel projects in diatomite strata.
基金supported by Sichuan Natural Science Foundation(2024NSFSC1933,2024NSFSC1896 to J.X.)Bureau of Science and Technology Nanchong City(23JCYJPT0065,23JCYJPT0069,23JCYJPT0071,23JCYJPT0031 to J.X.)+2 种基金Research Project of Sichuan Medical Association(S23033 to J.X.)Outstanding Youth Fund Project of North Sichuan Medical College(CBY23-JQ02 to J.X.)Central-guided Local Science and Technology Project(2025ZYD0168).
摘要A 47-year-old female presented with the chief complaint of dull pain in right upper quadrant of abdomen for 10 days without jaundice.Routine laboratory tests were as follows,liver function tests showed an alanine aminotransferase(ALT)level of 49 U/L(normal range,15-40 U/L),an aspartate aminotransferase(AST)level of 96 U/L(normal range,15-40 U/L),a gamma glutamyl transpeptidase(GGT)level of 164 U/L(normal range,10-60 U/L),a total bilirubin(TBil)level of 23.4μmol/L(normal range,1.7-13.7µmol/L).
基金financial and intellectual support provided by Queensland University of Technology(QUT)through its Higher Degree Research Program.
摘要The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the pavement structure increases the load-carrying capacity of unbound pavement layers by providing lateral restraint,improving vertical stress distribution,and enhancing bearing capacity.Such reinforcement typically aims to either improve the service life of pavements or achieve equivalent performance with a reduced granular cover.Previous and ongoing research quantifies geosynthetic performance in pavement reinforcement using various testing methods.Among these,laboratory model box tests subjected to cyclic loading are pivotal,as they closely replicate real-world traffic conditions.Hence,these studies are essential for understanding how geosynthetics distribute loads and enhance pavement durability.This facilitates the development of optimized geosynthetic design and installation practices,accelerating the loading process to simulate years of traffic wear in a shorter period.This review discusses the improved rutting resistance of unbound pavements reinforced with geosynthetic materials,specifically drawing on data from cyclic plate load tests conducted on laboratory model boxes,as highlighted in the literature.Key variables such as optimum geosynthetic placement,geosynthetic material properties,performance of different geosynthetic materials and the effects of aperture shape and size on rutting resistance are discussed.Furthermore,the review assesses various predictive rutting models,analysing their applicability and accuracy in forecasting the rutting performance of geosynthetic-reinforced unbound pavements.This comprehensive literature review aids pavement engineers and researchers,in guiding the selection and design of geosynthetics to optimize pavement durability and functionality under repetitive traffic loads.
摘要A series of polyester, cotton, and polyester/cotton blend fabrics were evaluated in a subjective wear. Subjective trial data were correlated with the results of in-house laboratory tests with the regression methods. Experimental results indicate that clothing-comfort assessment by human perception provides a sound basis for comparison of apparel garments under combined microclimates and human-activity levels of
摘要The performance evaluation of gas turbine inlet air filtration systems is commonly based on standardized laboratory testing;however,discrepancies frequently arise between laboratory results and actual operating performance.In this study,an on-site testing apparatus was developed to investigate filtration behavior under realistic operating conditions.Field measurements were conducted to analyze pressure loss evolution,particle-size-dependent filtration efficiency,and the influence of environmental parameters,including temperature,humidity,and ambient particulate concentration.Results show that filter pressure loss increased progressively with operational loading,while short-term fluctuations were associated with variations in environmental conditions.Filtration efficiency exhibited an overall increasing tendency with particle size,with minor fluctuations observed at larger particle sizes,and showed limited dependence on pressure loss within the investigated operating range.Correlation analysis indicated that ambient temperature showed a stronger relationship with filtration efficiency compared with humidity and differential pressure,suggesting that environmental conditions play an important role in practical filtration performance.To evaluate the consistency between laboratory certification and field operation,comparative tests were carried out at three representative gas turbine power plants operating under different environmental conditions.Although laboratory and field results demonstrated similar efficiency trends,noticeable quantitative deviations were observed.Correction factors relating laboratory-tested efficiency to field-measured efficiency were determined as 0.82,0.86,and 0.54 for the three sites,respectively.The proposed correction-coefficient approach provides a practical method for translating standardized laboratory performance into realistic operational evaluation,offering useful guidance for filter selection,performance assessment,and operational management of gas turbine inlet air filtration systems.
基金Project(50778180) supported by the National Natural Science Foundation of ChinaProject(CX2010B049) supported by Hunan Provincial Innovation Foundation for Postgraduate,China
摘要In order to study the engineering behaviors of reinforced gabion retaining wall,laboratory model test was carried out.Cyclic load and unload of five levels(0-50,0-100,0-50,0-200 and 0-250 kPa) were imposed.Vertical earth pressure,lateral earth pressure,deformation behaviors of reinforcements,potential failure surface and deformation behaviors of wall face were studied.Results show that vertical earth pressure is less than theoretical value,the ratio of vertical earth pressure to theoretical value increases nearly linearly with increasing load,and the correlation coefficient of regression equation is 0.92 for the second layer and 0.79 for the fifth layer.The distribution of lateral earth pressure along the wall back is nonlinear and it is less than theoretical value especially when the load imposed at the top of retaining wall is large.Therefore,reinforced gabion retaining wall will be in great safety when current method is adopted.The deformation behaviors of reinforcements both in the third layer and the fifth layer are single-peak distributions,and the position of the maximum strain is behind that determined by 0.3H(Here H refers to the height of retaining wall) method or Rankine theory.Lateral deformation of wall face increases with increasing load,and the largest lateral deformation occurs in the fourth layer,which lead to a bulging in the middle of wall face.
摘要The deformation of sea coast or sandy deposits caused by earthquakes can lead to catastrophic damages to various port structures. The volumetric deformation is mainly induced by densification of sand during the dissipation of excess pore water pressure created by cyclic loading. Based on laboratory test, the reconsolidation volumetric characteristics of saturated sea sand are investigated. The experiments are conducted with a newly developed multi functional triaxial test equipment. Two types of dynamic loads are applied to the samples to clarify different kinds of affecting factors. It is found that the reconsolidation volumetric strain is correlated not only to the excess pore water pressure and the maximum shear strain during the dynamic loading, but also to the effective confining pressure. A new formula is put forward to calculate the volumetric strain during reconssolidation.