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Shared genetic link and causal inference between blood lipids,lipid-lowering drugs and amyotrophic lateral sclerosis 认领 引用
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作者 Kailin Xia Ninghao Huang +7 位作者 Yajun Wang Gan Zhang Lu Tang Linjing Zhang Minhao Yao Zhonghua Liu Tao Huang Dongsheng Fan 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3824-3830,共7页
Growing evidence suggests that abnormal lipid metabolism occurs in amyotrophic lateral sclerosis,even in the presymptomatic stage,implying an etiologic link.However,the genetic mechanism underlying altered lipid level... Growing evidence suggests that abnormal lipid metabolism occurs in amyotrophic lateral sclerosis,even in the presymptomatic stage,implying an etiologic link.However,the genetic mechanism underlying altered lipid levels in amyotrophic lateral sclerosis remains elusive.Therefore,in this study,we performed genetic correlation analysis,a cross-trait meta-analysis,tissue-specific enrichment analysis,and bidirectional two-sample Mendelian randomization analysis of European population to explore whether there is a genetic and causal relationship between lipids and amyotrophic lateral sclerosis.The effect of lipid-lowering drugs on amyotrophic lateral sclerosis was also evaluated using a drug target Mendelian randomization approach.The results showed a positive genetic correlation between amyotrophic lateral sclerosis and both high-density lipoprotein cholesterol and apolipoprotein A1 and identified 71 independent shared loci between amyotrophic lateral sclerosis and high-density lipoprotein cholesterol,as well as 55 independent shared loci between amyotrophic lateral sclerosis and apolipoprotein A1.These shared loci were enriched in the lipid metabolic pathway and the alcohol metabolic pathway.Further Mendelian randomization analysis targeting lipid-lowering drugs showed that single nucleotide polymorphisms within the ACLY and PCSK9 genes had a protective effect against amyotrophic lateral sclerosis risk by decreasing low-density lipoprotein cholesterol.The combination of ACLY and PCSK9 inhibitors has a greater protective effect on amyotrophic lateral sclerosis risk than that of PCSK9 inhibitors alone.In summary,there is a common genetic structure between lipids and amyotrophic lateral sclerosis.Mendelian randomization analysis supports an association between elevated blood lipids and the risk of developing amyotrophic lateral sclerosis,and the use of ACLY or PCSK9 inhibitors may improve disease prognosis. 展开更多
关键词 amyotrophic lateral sclerosis genetic correlation genetics instrumental variables lipid-lowering drug lipids Mendelian randomization metabolism nerve regeneration neurodegenerative disease risk factor
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Comparative characterization of triacylglycerols in human milk,infant formula,structured lipids,and plant oils using UPSFC-Q-TOF-MS 认领 引用
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作者 Jiayao Zhou Yan Chen +3 位作者 Jiadi Yan Chunlin Wang Xingguo Wang Wei Wei 《Grain & Oil Science and Technology》 EI CAS 2026年第1期11-20,共10页
Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic a... Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic acid rapeseed oil)were analyzed and compared using ultraperformance supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPSFC-Q-TOF-MS).Distinct TAG profiles were identified by lipidomics,principal component analysis(PCA),and heatmap visualization.Human milk was characterized by a high abundance of medium-and long-chain triacylglycerols(MLCTs),saturated-unsaturated-unsaturated(SUU)-type TAGs(sn-2 palmitic acid).In contrast,plant oils lacked MLCTs and SUU-type TAGs,containing mainly TAGs esterified long-chain polyunsaturated fatty acid.Breast milk contains about 27%MLCT,about 50%SUU-type triacylglycerols(which contain about 34%UPU-type triacylglycerols),which is significantly different from plant oils,structured fats and infant formulas.These findings provide a clear basis for optimizing the fat blend in infant formula to better mimic the unique TAG profile of human milk,thereby improving energy delivery and nutrient absorption for infants. 展开更多
关键词 Triacylglycerol Milk lipids Human milk Infant formula Plant oil Medium-and long-chain triacylglycerol Palmitic acid Mass spectrometry
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Tetra-branched ionizable lipids enhance the stability and transfection efficiency of lipid nanoparticles for mRNA delivery 认领 引用
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作者 Haoran Xu Jiaqi Fan +12 位作者 Jiwei Liu Qi Wei Ruoshui Li Pengcheng Yuan Bing Xiao Ying Piao Wenjing Sun Jiajia Xiang Shiqun Shao Zhuxian Zhou Youqing Shen Nigel K.H.Slater Jianbin Tang 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第11期357-361,共5页
mRNA is a highly promising approach for disease prevention,yet its further application is currently limited by the low efficiency of delivery.Lipid nanoparticles(LNPs)are the mainstream delivery vehicles at present,an... mRNA is a highly promising approach for disease prevention,yet its further application is currently limited by the low efficiency of delivery.Lipid nanoparticles(LNPs)are the mainstream delivery vehicles at present,and ionizable lipids,as a key component,have a particularly significant impact on delivery efficiency.To improve the efficiency of delivery,a library of ionizable lipids with tetra-branched hydrophobic tails was designed and synthesized by the Michael addition reaction.From this library,the lipid 10A was selected for the highest delivery efficiency.Further formulation screening yielded LNPs with excellent performance,which showed good efficacy in tumor prevention experiments.At the same time,the structure-activity relationship between the ionizable lipid structure and the delivery efficiency was elucidated.It was that the tetra-branched hydrophobic tails,as compared with the di-branched hydrophobic tails enhanced the stability of LNPs,provided uniformity of particle size and improved the efficiency of endocytosis and lysosomal escape,resulting in higher delivery efficiency.Meanwhile,tetra-branched lipids with hydroxyl groups in the head group performed even better.This research provides a theoretical basis and foundation for guiding the development of the next generation of ionizable lipids,and the developed 10A LNP also shows broad prospects for clinical translation. 展开更多
关键词 mRNA vaccine Lipid nanoparticles Tetra-branched lipids Structure-activity relationship mRNA delivery
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Engineering a modular pectin-to-lipids bioconversion system using two Kluyveromyces marxianus strains 认领 引用
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作者 Bofan Yu He Qiao Xuye Lang 《Bioresources and Bioprocessing》 SCIE EI CSCD 2025年第1期1360-1373,共14页
Pectin production by processing renewable feedstocks is an appealing and sustainable approach.However,microbial valorization of pectin remains underdeveloped and necessitates efficient expression of key enzymes.In thi... Pectin production by processing renewable feedstocks is an appealing and sustainable approach.However,microbial valorization of pectin remains underdeveloped and necessitates efficient expression of key enzymes.In this study,we developed a novel two-stage microbial consortium for pectin valorization through modular utilization of engineered Kluyveromyces marxianus strains.CRISPR-mediated integration of PGU1 in strain YKM1013 significantly increased endoPG production,enabling efficient pectin hydrolysis and achieving a 65%improvement in hydrolysis degree.Meanwhile,strain YKM1015,engineered with a synthetic D-galacturonic acid(D-galUA)metabolic pathway,demonstrated efficient utilization of available D-galUA components.The established bioprocess achieved remarkable lipids productivity,yielding 19-fold and 6-fold increases in medium-chain fatty acid(MCFA)and long-chain fatty acid(LCFA)production,respectively,thereby establishing the microbial platform for direct pectin-to-lipids bioconversion.Collectively,these advances provided a feasible bioconversion route for valorizing pectin-rich biomass into high-value chemicals via microbial cell factory platform construction. 展开更多
关键词 Kluyveromyces marxianus Pectin utilization Lipids production Modular system Metabolic engineering
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Fucoxanthin improves serum lipids,liver metabolism and gut microbiota in hyperlipidemia mice 认领 引用 被引量：1
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作者 Yonghui Zhou Jingyi Zhang +4 位作者 Kun Xu Weihao Zhang Feng Chen Bin Liu Bingbing Guo 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第1期236-249,共14页
Fucoxanthin,a kind of exclusively algae-derived carotenoids,could reduce lipid content and regulate gut microbiota composition in obese mice,showing potential in preventing hyperlipidemia.This study aimed to illustrat... Fucoxanthin,a kind of exclusively algae-derived carotenoids,could reduce lipid content and regulate gut microbiota composition in obese mice,showing potential in preventing hyperlipidemia.This study aimed to illustrate fucoxanthin efficacy in modulating lipid metabolism in serum and liver of high-fat-induced hyperlipidemia mice,as well as investigate the underlying association with gut microbiota changes.Results showed that fucoxanthin significantly reduced body weight gain and body white fat of the mice.In the serum,total triglycerides(TG),total cholesterol(TC)contents were significantly decreased and high-densitylipoprotein cholesterol levels was significantly upregulated.Moreover,fucoxanthin remarkedly prevented lipid accumulation in the liver.Especially,metabolomics results showed that lipids and lipid-like molecules were significantly downregulated compared with the control,indicating the advance of hepatic lipid metabolism.Bile acids profile in the liver was also greatly changed by fucoxanthin.Meanwhile,fucoxanthin remodeled gut microbiota composition and promoted the relative abundance of Desulfovibrio,Blautia and Clostridia genera.Finally,correlation analysis revealed that these gut microbiota changes were closely related with hepatic metabolites/metabolism and serum lipids.Altogether,this study showed great potential of fucoxanthin in improving serum lipids profile,hepatic lipids and bile acids metabolism of hyperlipidemia mice,which was associated with gut microbiota alteration. 展开更多
关键词 Fucoxanthin Lipids Hyperlipidemia Liver metabolism Gut microbiota
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Mycelial mass,microbial lipids and γ-linolenic acid(GLA)by Cunninghamella elegans cultivated on agro-industrial residues 认领 引用 被引量：1
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作者 Gabriel Vasilakis Afef Gamraoui +5 位作者 Dimitris Karayannis Nikos Giannakis Abdelwaheb Chatti Ioannis Politis Panagiota Diamantopoulou Seraphim Papanikolaou 《Resources Chemicals and Materials》 2025年第1期64-76,共13页
In the current study,the Zygomycetes fungus Cunninghamella elegans NRRL Y-1392 was evaluated for its ability to grow in extracts derived from dried and ground agricultural residues,such as mushroom stalks and roots fr... In the current study,the Zygomycetes fungus Cunninghamella elegans NRRL Y-1392 was evaluated for its ability to grow in extracts derived from dried and ground agricultural residues,such as mushroom stalks and roots from hydroponically cultivated lettuces and produce poly-unsaturated fatty acids(PUFA)andγ-linolenic acid(GLA)rich lipids.Initially,the compositions of stalks and lettuce roots were analysed,and the fungus was batch-flask cultivated on six different commercial semi-defined substrates containing different sugars detected in stalks and roots to evaluate its catabolic ability.C.elegans was capable to assimilate all sugars,but at a lower rate in the case of arabinose.Subsequently,C.elegans was cultivated on tailor-made semi-defined commercial substrates,resembling hydrolysates containing carbohydrates found in mushroom stalks,under both nitrogen-excess and nitrogen-limited conditions,and resembling that of hydrolysates of roots,under nitrogen-excess conditions.Based on the results,under nitrogen-excess conditions,in the case of media resembling stalks hydrolysates,higher production values for biomass,PUFAs,and GLA were observed(20.3 g/L,1906 mg/L,668 mg/L),accompanied by high productivity values due to short cultivation periods,while under nitrogen limitation,high lipid accumulation(lipid in dry cell weight=48%,w/w)was presented,and lipids rich in oleic acid were produced.Finally,the fungus was cultivated on a medium derived from hot water-extraction applied to mush-room stalks,enriched with organic nitrogen sources.The fungus was successfully grown on the sugar-rich waterextract derived from mushroom stalks,resulting in dry biomass of 14.5 g/L,lipids of 1.8 g/L,with 15%(w/w)of GLA in cellular lipids. 展开更多
关键词 Agro-industrial residues Circular economy Cunninghamella elegans Gamma-linolenic acid Microbial lipids Polyunsaturated fatty acids
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Impact of dietary lysophospholipids supplementation on growth performance, meat quality, and lipid metabolism in finishing bulls fed diets varying in fatty acid saturation 认领 引用
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作者 Meimei Zhang Haixin Bai +5 位作者 Ruixue Wang Yufan Zhao Wenzhu Yang Jincheng Liu Yonggen Zhang Peixin Jiao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第2期831-844,共14页
Background The objective of this study was to evaluate the effects of dietary fatty acids(FA)saturation and lysophospholipids supplementation on growth,meat quality,oxidative stability,FA profiles,and lipid metabolism... Background The objective of this study was to evaluate the effects of dietary fatty acids(FA)saturation and lysophospholipids supplementation on growth,meat quality,oxidative stability,FA profiles,and lipid metabolism of finishing beef bulls.Thirty-two Angus bulls(initial body weight:623±22.6 kg;21±0.5 months of age)were used.The experiment was a completely randomized block design with a 2×2 factorial arrangement of treatments:2 diets with FA of different degree of unsaturation[high saturated FA diet(HSFA)vs.high unsaturated FA diet(HUFA)]combined with(0.075%,dry matter basis)and without lysophospholipids supplementation.The bulls were fed a high-concentrate diet(forage to concentrate,15:85)for 104 d including a 14-d adaptation period and a 90-d data and sample collection period.Results No interactions were observed between dietary FA and lysophospholipids supplementation for growth and meat quality parameters.A greater dietary ratio of unsaturated FA(UFA)to saturated FA(SFA)from 1:2 to 1:1 led to lower DM intake and backfat thickness,but did not affect growth performance and other carcass traits.Compared with HSFA,bulls fed HUFA had greater shear force in Longissimus thoracis(LT)muscle,but had lower intramuscular fat(IMF)content and SOD content in LT muscle.Compared with HUFA,feeding the HSFA diet up-regulated expression of ACC,FAS,PPARγ,and SCD1,but down-regulated expression of CPT1B.Compared with feeding HSFA,the HUFA diet led to greater concentrations of c9-C18:1 and other monounsaturated FA in LT muscle.Feeding HUFA also led to lower plasma concentrations of cholesterol,but there were no interactions between FA and lysophospholipids detected.Feeding lysophospholipids improved growth and feed conversion ratio and altered meat quality by increasing muscle pH24h,redness values(24 h),IMF content,and concentrations of C18:3,C20:5 and total polyunsaturated fatty acids.Furthermore,lysophospholipids supplementation led to lower malondialdehyde content and up-regulated the expression of ACC,FAS,and LPL in LT muscle.Conclusions Results indicated that supplementing a high-concentrate diet with lysophospholipids to beef bulls can enhance growth rate,feed efficiency,meat quality,and beneficial FA.Increasing the dietary ratio of UFA to SFA reduced DM intake and backfat thickness without compromising growth,suggesting potential improvements in feed efficiency. 展开更多
关键词 Bulls Fatty acids Lipid metabolism Lysophospholipids Meat quality
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Lipids,cholesterols,statins and COPD:a Mendelian randomization study 认领 引用
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作者 Wei-Zhen Guo Gang Cheng +3 位作者 Jian Ding Tan-Tan Huang Xiao Ma Ze-Geng Li 《Medical Data Mining》 CAS 2025年第1期41-49,共9页
Background:Chronic obstructive pulmonary disease(COPD)is a prevalent respiratory ailment that has risen to become the foremost cause of mortality globally,and statins are a widely used class of lipid-modifying drugs.D... Background:Chronic obstructive pulmonary disease(COPD)is a prevalent respiratory ailment that has risen to become the foremost cause of mortality globally,and statins are a widely used class of lipid-modifying drugs.Data from some observational studies suggest an association between statins use and COPD.Objectives:The main objective of this study was to investigate whether lipids and apolipoproteins are bidirectionally causally associated with COPD at the genetic level using a Mendelian randomization(MR)design,and to determine the potential role of circulating inflammatory proteins as mediators in this association.Methods:The publicly available Genome-Wide Association Study(GWAS)database was utilised for the purposes of the analysis.The data on high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),triglycerides(TG),apolipoprotein A-1(ApoA1),and apolipoprotein B(ApoB)were obtained from the UK BioBank,while the COPD dataset was obtained from the FinnGen BioBank R11(number of cases:21,617,number of controls:372,627).Furthermore,data were gathered on genetic variants linked to inflammatory processes,encompassing 91 circulating inflammatory proteins(n=14,823 individuals).A two-sample MR study was conducted using these data to assess the association between HDL-C,LDL-C,TG,ApoA1,and ApoB with the risk of COPD.Furthermore,in order to investigate the potential mediating influence of inflammatory factor alterations between lipids and COPD,a two-step Mendelian randomization(MR)mediation analysis was conducted.Results:The forward MR methods identified two lipids that were found to have a causal relationship with the development of COPD.An elevated level of LDL-C and ApoB was found to be associated with a diminished risk of COPD.Furthermore,the researchers identified circulating inflammatory factors that were determined to be the causal agents in the development of COPD.Mediation analysis indicated that the inflammatory protein S100-A12 may act as a mediator between the LDL-C and COPD pathways.Conclusion:The present MR study provides genetic evidence for a causal relationship between lipids and apolipoproteins and COPD,as well as identifying the inflammatory protein S100-A12 as a potential mediator of the COPD association.The findings offer valuable insights into the mechanistic studies of statins for COPD and potential targets for disease intervention and treatment. 展开更多
关键词 lipids apolipoproteins COPD genetic prediction Mendelian randomization inflammatory factors
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Raman analysis of lipids in cells:Current applications and future prospects 认领 引用 被引量：1
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作者 Yixuan Zhou Yuelin Xu +1 位作者 Xiaoli Hou Daozong Xia 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第4期665-678,共14页
Lipids play an important role in the regulation of cell life processes.Although there are various lipid detection methods,Raman spectroscopy,a non-invasive technique,provides the detailed chemical composition of lipid... Lipids play an important role in the regulation of cell life processes.Although there are various lipid detection methods,Raman spectroscopy,a non-invasive technique,provides the detailed chemical composition of lipid profiles without a complex sample preparation procedure and possesses greater potential in basic biology,clinical diagnosis and disease therapy.In this review,we summarized the characteristics and advantages of Raman-based techniques and their primary contribution to illustrating cellular lipid metabolism. 展开更多
关键词 Raman spectroscopy Raman image Cellular lipid metabolism Adipocytes Cancer cell
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iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides 认领 引用 被引量：1
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作者 Xiaofei Xu Xiaofei Liu +2 位作者 Jin Chen Jingjing Guan Donghui Luo 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第5期1840-1853,共14页
The mechanisms of mushroom polysaccharides on immune functions and lipid metabolism of aged mammals have not been fully elucidated.In the present study,after assessing the impacts of one type of Lentinula edodes-deriv... The mechanisms of mushroom polysaccharides on immune functions and lipid metabolism of aged mammals have not been fully elucidated.In the present study,after assessing the impacts of one type of Lentinula edodes-derived polysaccharides,named L2,on immune functions and blood lipid profiles,isobaric tags for relative and absolute quantification(iTRAQ)-based proteomic profiling of the small intestinal tissues from aged mice treated with L2 was performed.L2 reversed immune function declines and modulated the lipid metabolism of aged mice evidenced by increased levels of serum TC,HDL-C,and LDL-C,and reduced levels of serum TG.Moreover,a total of 95 differentially regulated proteins(DRPs) were identified,of which75 were up-regulated and 20 were down-regulated.Most of the DRPs were involved in intracellular and extracellular structure organization,and cellular and metabolic regulation.Particularly,approximately 16 and 9 DRPs participated in the regulation of immune functions and lipid metabolism,respectively.Furthermore,protein-protein interaction analysis highlighted that cadherin-1,plectin,cadherin-17,Ras GTPase-activating-like protein IQGAP2,and ezrin might be key proteins in response to L2 treatment.These findings provide new insights into the biological mechanisms of mushroom polysaccharides in anti-aging from a proteomic perspective. 展开更多
关键词 Mushroom polysaccharides Immune function Isobaric tags for relative and absolute quantification(iTRAQ)proteomics Blood lipid Intestinal tissue
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Unlocking the unique impact of yellow meat lipids on the flavor profile of sturgeon surimi gel 认领 引用
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作者 Lu Tong Yongjie Zhou +5 位作者 Peipei Dou Yanyan Zheng Yan Zhang Hui Hong Yongkang Luo Yuqing Tan 《Food Innovation and Advances》 2025年第2期149-158,共10页
Lipids play a crucial role in both the creation and transport of volatile compounds(VCs)in surimi products.This study explored how the unique lipid of sturgeon yellow meat influences the flavor profile of sturgeon sur... Lipids play a crucial role in both the creation and transport of volatile compounds(VCs)in surimi products.This study explored how the unique lipid of sturgeon yellow meat influences the flavor profile of sturgeon surimi gels,distinguishing them from traditional freshwater surimi,such as silver carp.The electronic nose revealed significant differences between the VCs of yellow meat surimi gel(YS)and white meat surimi gel(WS).Gas chromatography–ion mobility spectrometry analysis detected 30 VCs,with 10 significantly up-regulated and three down-regulated in YS compared to WS.Sensory evaluation identified eight flavor descriptors:oily/fatty,earthy,grassy,unpleasant fishy,meaty,cheesy/milky,sweet,and fresh.YS was found to contribute primarily to undesirable oily/fatty,unpleasant fishy,and earthy notes,while simultaneously enhancing the more desirable cheesy/milky and sweet flavors.Unlike silver carp surimi,which is often characterized by pronounced earthy,grassy,and metallic flavors,sturgeon surimi gels were free from metallic flavors.Partial least squares regression analysis revealed that specific compounds such as 4-methyl-2-pentanone and 3-methylbutanal were strongly associated with key flavor attributes like oily/fatty and cheesy/milky,further distinguishing sturgeon surimi from traditional surimi products.This study highlights the distinctive flavor potential of sturgeon surimi,offering new opportunities for surimi product innovation. 展开更多
关键词 volatile compounds vcs sturgeon yellow meat chromatography ion mobility spectrometry analysis flavor profile sturgeon surimi gelsdistinguishing yellow meat lipids electronic nose yellow meat surimi
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Effects of nicorandil combined with atorvastatin on vascular endothelial function,blood lipids,and inflammatory factors in coronary heart disease patients with myocardial ischemia 认领 引用 被引量：1
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作者 LU Cheng-bin 《South China Journal of Cardiology》 CAS 2025年第4期292-299,共8页
Background Coronary heart disease with myocardial ischemia is closely associated with vascular endothelial dysfunction,dyslipidemia,and chronic inflammatory response.Atorvastatin,a classic lipid-lowering agent,exhibit... Background Coronary heart disease with myocardial ischemia is closely associated with vascular endothelial dysfunction,dyslipidemia,and chronic inflammatory response.Atorvastatin,a classic lipid-lowering agent,exhibits pleiotropic effects including plaque stabilization,endothelial function improvement,and anti-inflammatory actions.Nicorandil,as a potassium channel opener with additional nitrate-like effects,directly dilates coronary arteries and improves myocardial microcirculation.Theoretically,the two drugs may synergistically enhance myocardial perfusion and endothelial function through distinct mechanisms.However,clinical evidence regarding the comprehensive impact of their combination on vascular endothelial function,blood lipid profiles,and systemic inflammatory status in patients with coronary heart disease and myocardial ischemia remains insufficient.Further studies are warranted to clarify their synergistic effects and clinical value.Methods A total of 60 patients with coronary heart disease and myocardial ischemia admitted to our hospital from January 2023 to October 2024 were enrolled and randomly divided into combination group and control group using a random number table,with 30 patients in each group.The control group received atorvastatin treatment,while the combination group received nicorandil combined with atorvastatin.After 12 weeks of continuous treatment,the clinical efficacy,vascular endothelial function,blood lipid profiles,inflammatory factors,and adverse reactions were compared between the two groups.Results The total effective rate in the combination group(93.33%)was significantly higher than that in the control group(70.00%)(P0.05).Conclusions The combination of nicorandil and atorvastatin demonstrated certain short-term therapeutic effects in patients with coronary heart disease and myocardial ischemia.It not only effectively improves vascular endothelial function and regulates lipid metabolism but also suppresses the levels of inflammatory factors,with a favorable safety profile. 展开更多
关键词 Nicorandil Atorvastatin Coronary heart disease Myocardial ischemia Vascular endothelial function Blood lipids
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Efficient serum lipids profiling by TiO2-dopamin-assisted MALDI-TOF MS for breast cancer detection 认领 引用 被引量：1
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作者 Xinyue Han Yunhan Yang +4 位作者 Jiayin Lu Yuxiang Lin Dongxue Zhang Ling Lin Liang Qiao 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第5期651-657,共7页
Lipids serve as fundamental constituents of cell membranes and organelles.Recent studies have highlighted the significance of lipids as biomarkers in the diagnosis of breast cancer.Although liquid chromatography coupl... Lipids serve as fundamental constituents of cell membranes and organelles.Recent studies have highlighted the significance of lipids as biomarkers in the diagnosis of breast cancer.Although liquid chromatography coupled with tandem mass spectrometry(LC-MS/MS)is widely employed for lipid analysis in complex samples,it suffers from limitations such as complexity and time-consuming procedures.In this study,we have developed dopamine-modified TiO2nanoparticles(TiO2-DA)and applied the materials to assist the analysis of lipids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS).The TiO2-DA can provide large specific surface area and acidic environment,well suited for lipid analysis.The method was initially validated using standard lipid molecules.Good sensitivity,reproducibility and quantification performance was observed.Then,the method was applied to the analysis of 90 serum samples from 30 patients with breast cancer,30 patients with benign breast disease and 30 healthy controls.Five lipid molecules were identified as potential biomarkers for breast cancer.We constructed a classification model based on the MALDI-TOF MS signal of the 5 lipid molecules,and achieved high sensitivity,specificity and accuracy for the differentiation of breast cancer from benign breast disease and healthy control.We further collected another 60 serum samples from 20 healthy controls,20 patients with benign breast disease and 20 patients with breast cancer for MALDITOF MS analysis to verify the accuracy of the classification model.This advancement holds great promise for the development of diagnostic models for other lipid metabolism-related diseases. 展开更多
关键词 Lipid MALDI-TOF MS Breast cancer Machine learning TiO2
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Exploring the Clinical Value of Combined Detection of Blood Lipids, Blood Glucose, and Liver Function in Non-alcoholic Fatty Liver Disease 认领 引用
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作者 Jinyuan Gong 《Journal of Clinical and Nursing Research》 2025年第2期147-152,共6页
Objective:To study the clinical value of combined detection of blood lipids,blood glucose,and liver function in non-alcoholic fatty liver disease.Methods:105 patients with non-alcoholic fatty liver disease treated in ... Objective:To study the clinical value of combined detection of blood lipids,blood glucose,and liver function in non-alcoholic fatty liver disease.Methods:105 patients with non-alcoholic fatty liver disease treated in our hospital from May 2022 to July 2024 were selected as the research subjects.All patients underwent a B-ultrasound examination.According to the severity of the disease,they were divided into group A(mild,n=35),group B(moderate,n=44),and group C(severe,n=26).Another 30 healthy residents who came to the hospital for physical examination during the same period were selected as group D.The differences in blood lipids,blood glucose,and liver function indicators between groups were compared.Results:The triglyceride(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL)levels in groups A,B,and C were higher than those in group D,while the high-density lipoprotein cholesterol(HDL)level was lower(P<0.05).The fasting plasma glucose(FPG)levels in groups B and C were higher than those in group D(P<0.05).The TG,LDL,and FPG levels in groups B and C were higher than those in group A(P<0.05).The TC level in group C was higher than that in group A,while the HDL level was lower(P<0.05).The TC and FPG levels in group C were higher than those in group B(P<0.05).The total bilirubin(TBil),aspartate aminotransferase(AST),and alanine aminotransferase(ALT)levels in groups A,B,and C were higher than those in group D(P<0.05).The TBil and ALT levels in groups B and C were higher than those in group A(P<0.05).The AST level in group C was higher than that in group A(P<0.05).The AST and ALT levels in group C were higher than those in group B(P<0.05).Conclusion:Patients with non-alcoholic fatty liver disease have disordered glucose and lipid metabolism.Blood lipids,blood glucose,and liver function are closely related to the severity of the disease.Strengthening exercise and dietary intervention early on can help control the progression of simple fatty liver disease and reduce the risk of severe liver diseases such as steatohepatitis and cirrhosis. 展开更多
关键词 Non-alcoholic fatty liver disease Blood lipids Blood glucose Liver function
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Association between dairy intake,lipids and vascular structure and function in diabetes 认领 引用
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作者 Kristina S Petersen Jennifer B Keogh +3 位作者 Natalie Lister Jacquelyn M Weir Peter J Meikle Peter M Clifton 《World Journal of Diabetes》 SCIE 2017年第5期202-212,共11页
AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure... AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function.METHODS A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and 12-mo.RESULTS Serum lipid species [lysophosphatidylcholine(LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine(PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; P < 0.05). The 3-mo change in some lipids was positively associated with the 3-mo change in central systolic [LPC 14:0(rho 0.30; P = 0.007), PC 30:0(rho 0.28; P = 0.010)] and diastolic blood pressure [LPC 14:0(rho 0.32; P = 0.004), LPC 15:0(rho 0.23; P = 0.04), LPC 16:1(rho 0.23; P = 0.035), PC 29:0(rho 0.28; P = 0.01), PC 30:0(rho 0.36; P = 0.001), PC 31:0(rho 0.30; P = 0.007)] and 12-mo change in common carotid artery intimal medial thickness [CE 14:0(rho 0.22; P = 0.02)]. Pulse wave velocity and augmentation index were unrelated to dairy and lipid species.CONCLUSION An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness. 展开更多
关键词 Lipids Phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness Pulse wave velocity Diabetes
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Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015 认领 引用 被引量：125
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作者 SONG Peng Kun MAN Qing Qing +6 位作者 LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2019年第8期559-570,共12页
Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blo... Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. 展开更多
关键词 Lipids Dyslipidemia Cross-sectional study Adults China
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Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients 认领 引用 被引量：19
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作者 Hui-yan ZHANG Jian-yong WANG +2 位作者 Gui-shuang YING Li-ping SHEN Zhe ZHANG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2013年第5期392-399,共8页
Objective: To investigate the association of serum lipids and other risk factors with diabetic retinopathy (DR) in Chinese type 2 diabetic patients. Methods: Five hundred and twenty-three type 2 diabetic patients unde... Objective: To investigate the association of serum lipids and other risk factors with diabetic retinopathy (DR) in Chinese type 2 diabetic patients. Methods: Five hundred and twenty-three type 2 diabetic patients underwent ophthalmic examination by experienced retinal specialists to assess their DR. Serum lipids, including triglycerides, total cholesterol, high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC), were measured using Roche automated clinical chemistry analyzers. The concentration of very low density lipoprotein cholesterol (VLDLC) was calculated based on total cholesterol, HDLC and LDLC. Hyperlipidemia was defined as a total cholesterol concentration of 6.2 mmol/L or higher or the use of lipid-lowering medications. The association of risk factors with any DR or proliferative diabetic retinopathy (PDR) was assessed using the odds ratio (OR) and its 95% confidence interval (CI), calculated from logistic regression models. Results: In multivariate logistic regression models, hyperlipidemia (OR=2.39, 95% CI: 1.02-5.66), higher VLDLC (OR=1.59, 95% CI: 1.14-2.23), and higher triglyceride (OR=1.18, 95% CI: 1.03-1.37) were associated with increased risk of DR. A longer diabetic duration was associated with increased risk of DR (P<0.0001) and PDR (P=0.002) in a dose-response manner. Higher systolic blood pressure (P=0.02) and higher serum creatinine (P=0.01) were independently associated with increased risk of DR, and female gender was associated with increased risk of PDR (P=0.03). Conclusions: Among Chinese type 2 diabetic patients, hyperlipidemia, higher VLDLC, and higher triglyceride were independently associated with increased risk of DR, suggesting control of serum lipids may decrease the risk of DR. 展开更多
关键词 Diabetic retinopathy Serum lipids Risk factors
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Review:Lipids changes in liver cancer 认领 引用 被引量：9
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作者 JIANG Jing-ting XU Ning +1 位作者 ZHANG Xiao-ying WU Chang-ping 《Journal of Zhejiang University-SCIENCE B》 EI CAS 2007年第6期398-409,共12页
Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, ... Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV). HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer. 展开更多
关键词 Lipids Lipoprotein Liver cancer
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Exploiting styrene-maleic acid copolymer grafting chromatographic stationary phase materials for separation of membrane lipids 认领 引用 被引量：3
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作者 Mengying Liang Delu Liu +2 位作者 Yangyang Nie Yanli Liu Xiaoqiang Qiao 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第6期3123-3126,共4页
High performance liquid chromatography-mass spectrometry is one of the most commonly used strategies for lipid analysis.The development of versatile chromatographic stationary phases to meet the increasing demands for... High performance liquid chromatography-mass spectrometry is one of the most commonly used strategies for lipid analysis.The development of versatile chromatographic stationary phases to meet the increasing demands for separation of complex lipids is very important.Styrene-maleic acid(SMA)copolymer is an amphiphilic polymer,which has been proven to have the ability to solubilize lipid molecules of various structures.In this study,styrene-maleic anhydride copolymer coated silica was first prepared by the thiol-ene click reaction.With L-cysteine hydrochloride or dodecanol as the post-modification reagents,Sil-SMA-amino acid and Sil-SMA-dodecanol stationary phase materials were further successfully fabricated via nucleophilic ring-opening reaction.The Fourier-transform infrared,thermogravimetric analysis,and elemental analysis results confirmed the two stationary phase materials were successfully prepared.Furthermore,both the Sil-SMA-dodecanol column and the Sil-SMA-amino acid column possessed reversed-phase/hydrophilic interaction/ion exchange mixed-mode retention mechanisms.The column efficiency of the Sil-SMA-derivatives columns reached 77,300 N/m.Based on the mixed-mode retention characteristics,the Sil-SMA-derivatives columns achieved both the lipid classes and species separation via a single column.The Sil-SMA-amino acid column was further successfully used to separate lipid extract from gastric cancer cell membrane.All these results demonstrated that the SMA-based stationary phase materials have a good potential for use in lipid separation. 展开更多
关键词 Styrene-maleic acid copolymer Mixed-mode Stationary phase Chromatographic separation Lipids
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Long-Term Effects of Docosahexaenoic Acid-Bound Phospholipids and the Combination of Docosahexaenoic Acid-Bound Triglyceride and Egg Yolk Phospholipid on Lipid Metabolism in Mice 认领 引用 被引量：3
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作者 CHE Hongxia CUI Jie +5 位作者 WEN Min XU Jie Teruyoshi Yanagita WANG Qi XUE Changhu WANG Yuming 《Journal of Ocean University of China》 SCIE CAS CSCD 2018年第2期392-398,共7页
The bioavailability of docosahexaenoic acid(DHA) and eicosapentaenoic acid(EPA) depends on their chemical forms. This study investigated the long-term effects of DHA-bound triglyceride(TG-DHA), DHA-bound phospholipid(... The bioavailability of docosahexaenoic acid(DHA) and eicosapentaenoic acid(EPA) depends on their chemical forms. This study investigated the long-term effects of DHA-bound triglyceride(TG-DHA), DHA-bound phospholipid(PL-DHA), and the combination of TG-DHA and egg yolk phospholipid(Egg-PL) on lipid metabolism in mice fed with a high-fat diet(fat levels of 22.5%). Male C57BL/6J mice were fed with different formulations containing 0.5% DHA, including TG-DHA, PL-DHA, and the combination of TG-DHA and Egg-PL, for 6 weeks. Serum, hepatic, and cerebral lipid concentrations and the fatty acid compositions of the liver and brain were determined. The concentrations of serum total triglyceride(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-c), and hepatic TG in the PL-DHA group and the combination group were significantly lower than those in the high-fat(HF) group(P < 0.05). Atherogenic index(AI) of the PL-DHA group was significantly lower than that of the combination group(P < 0.05). Hepatic TC level in the combination group was significantly lower than that in the HF group(P < 0.05), but no significant difference was observed between the combination group and the PL-DHA group. Both the PL-DHA and the combination groups showed significantly increased DHA levels in the liver compared with the HF group(P < 0.05). However, there were no obvious increases in the cerebral DHA levels in all DHA diet groups. These results suggest that PL-DHA was superior to the combination of TG-DHA and Egg-PL in decreasing the AI. Long-term dietary supplementation with low amount of DHA(0.5%) may improve hepatic DHA levels, although cerebral DHA levels may not be enhanced. 展开更多
关键词 omega-3 fatty acid docosahexaenoic acid eicosapentaenoic acid lipid metabolism triglycerides phospholipids
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