期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到6,139篇文章
< 1 2 … 250 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Liquid-Liquid Phase Separation in Cancer Drug Resistance:Mechanisms and Therapeutic Opportunities 认领 引用
1
作者 Yiyang Zhao Changchang Sun +3 位作者 Qihan Dong Jiangyang He Yan Wang Ling Bi 《Oncology Research》 SCIE 2026年第6期289-313,共25页
Liquid-liquid phase separation(LLPS)is an emerging biophysical principle that governs subcellular organization through the formation of dynamic,membraneless biomolecular condensates.This review aims to elucidate the m... Liquid-liquid phase separation(LLPS)is an emerging biophysical principle that governs subcellular organization through the formation of dynamic,membraneless biomolecular condensates.This review aims to elucidate the multifaceted mechanisms by which dysregulated LLPS drives cancer drug resistance and to explore therapeutic strategies targeting oncogenic biomolecular condensates for improved anticancer outcomes.We synthesize evidence demonstrating that dysregulated LLPS drives cancer drug resistance through diverse mechanisms,including sustaining oncogenic transcription despite targeted therapies,creating physical barriers against chemotherapeutics,modulating immune checkpoint activity,enhancing DNA damage repair,promoting cancer stemness and radioresistance.By integrating insights from cell cycle control,cytoskeletal dynamics,and critical tumor signaling pathways,we highlight the pervasive role of LLPS in facilitating adaptive tumor responses.We also discuss how multi-omics approaches and advanced biophysical techniques facilitate studies of condensate dynamics and prognostic signature identification.Finally,we address the challenges and opportunities in developing therapeutic strategies that target oncogenic condensates,a promising approach to counteract resistance and improve anticancer treatments. 展开更多
关键词 Liquid-liquid phase separation cancer drug resistance biomolecular condensates signaling pathways targeted therapy
暂未订购 下载PDF
Synthesis of reusable and portable SERS sandpaper based on liquid-liquid interface self-assembly method for stable and ultrasensitive detection of S-fenvalerate in foods 认领 引用
2
作者 Yingfang Zhang Chen Chen +4 位作者 Xinyue Wang Xuguang Qiao Ximo Wang Geoffrey I.N.Waterhouse Zhixiang Xu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期327-334,共8页
Herein,a reusable and portable surface-enhanced Raman spectroscopy(SERS)sandpaper was successfully synthesized for the sensitive detection of S-fenvalerate in foods.Commercial sandpapers were decorated with Ag@SiO2@Au... Herein,a reusable and portable surface-enhanced Raman spectroscopy(SERS)sandpaper was successfully synthesized for the sensitive detection of S-fenvalerate in foods.Commercial sandpapers were decorated with Ag@SiO2@Au nanoarrays via a liquid-liquid interface self-assembly method.The capacity of sandpaper to float directly on the cyclohexane-water interface allows nanoarrays to be formed directly on it,thereby minimizing stacking issues typically associated with nanoarray assemblies and significantly enhancing the sensitivity of S-fenvalerate detection.Moreover,the SERS sandpaper was reusable and portable due to its strong adhesion of the nanoarrays.Under optimized testing conditions,the developed SERS sandpaper method was capable of detecting S-fenvalerate,demonstrating a strong linear response within a concentration range of 10–7–103μmol/L,with a limit of detection of 1.92×10−8μmol/L.The analysis of spiked food samples containing S-fenvalerate using the developed SERS sandpaper afforded excellent recoveries(92.2%−109.7%).Additionally,the SERS sandpaper was successfully applied to quantify S-fenvalerate in real food samples,with results consistent with analyses conducted using gas chromatography. 展开更多
关键词 Surface-enhanced Raman spectroscopy Liquid-liquid interface self-assembly Reusable and portable SERS sandpaper S-Fenvalerate detection
暂未订购 下载PDF
Dispersive liquid-liquid microextraction combined with capillary electrophoresis for simultaneous determination of five fluoroquinolone antibiotics in marine crude drugs,seawater,and seafood samples 认领 引用
3
作者 Yingying LOU Guangli ZHAO +6 位作者 Jingyi YAN Dani SUN Jinmao YOU Huiquan XIAO Huitao LIU Guisheng LI Jinhua LI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第1期137-149,共13页
To simultaneously enrich,separate,and determine five fluoroquinolone antibiotics(FQs)in marine crude drugs(MCDs),seawater and seafood,we conducted this study using vortex assisted dispersed liquid-liquid microextracti... To simultaneously enrich,separate,and determine five fluoroquinolone antibiotics(FQs)in marine crude drugs(MCDs),seawater and seafood,we conducted this study using vortex assisted dispersed liquid-liquid microextraction(DLLME),followed by capillary electrophoresis(CE)-UV.A single-variable optimization was employed to examine the factors influencing the separation effect of CE and the extraction efficiency of DLLME,including buffer solution,organic solvent,separation voltage,extractant,dispersant,and sample solution pH.Under the optimal conditions,the baseline separation of the five FQs was achieved within 6 min.The analytical performance of the method was assessed using six types of actual samples,including three MCDs of hippocampus,clam,and kelp,seawater,and two seafood of prawn and pomfret,demonstrating good linearity ranging from 0.1-5 or 0.01-5μg/mL.The limits of detection(LODs)and limits of quantification(LOQs)for the five FQs in MCDs were 0.0022-0.0292 and 0.0066-0.0973μg/mL,respectively.The LODs and LOQs in seawater and seafood were 0.0009-0.0262 and 0.0029-0.0874μg/mL,respectively.The matrix effects of this method were evaluated in the hippocampus,seawater,and prawn,and the results show that DLLME could effectively eliminate matrix interference.Satisfactory recovery rates were achieved in all the six tested actual samples.This developed DLLME-CE method was proven simple to operate,accurate and reliable,with high sensitivity,making it suitable for the analysis of multiple antibiotic residues in complex matrices. 展开更多
关键词 fluoroquinolone antibiotic(FQ) dispersive liquid-liquid microextraction(DLLME) capillary electrophoresis(CE) marine crude drug(MCD) seafood seawater
暂未订购 下载PDF
Liquid-liquid phase separation in the nucleus:pathogenesis and therapy 认领 引用
4
作者 Zi-Ang Ma Zhong-Yong Zhang +7 位作者 Xiu-Min Gao Duo Wang Wei Wang Tong-Jin Liu Ya-Mei Gao Fei-Tian Min Huan-Tian Cui Shu-Quan Lv 《Biomedical Engineering Communications》 CAS 2025年第3期28-37,共10页
Intracellular liquid-liquid phase separation(LLPS)represents a pivotal biological process for the formation of cellular compartments,which involves the formation of droplet-like condensates through the hydrophobic and... Intracellular liquid-liquid phase separation(LLPS)represents a pivotal biological process for the formation of cellular compartments,which involves the formation of droplet-like condensates through the hydrophobic and hydrophilic interactions of biomolecules.LLPS plays a crucial role in normal cellular physiological activities,and it is also intimately linked to the pathological mechanisms of various diseases.This review summarizes the significant role of LLPS in regulating transcriptional mechanisms within the nucleus,with a focus on the mechanisms by which LLPS modulates gene transcription.Additionally,we highlight the roles of key proteins involved in LLPS,such as FOXK1,BRD4,Tau protein,and HDAC6,in the context of disease.We delve into the relationships between LLPS and diseases such as chronic kidney disease,atherosclerosis,Alzheimer’s disease,and triple-negative breast cancer,revealing the regulatory mechanisms of LLPS in disease onset and progression.Furthermore,we discuss the potential of pharmacological interventions targeting LLPS as novel therapeutic approaches,encompassing strategies such as gene therapy,traditional Chinese medicine monomers,and small-molecule inhibitors.In the future,a deeper understanding of the LLPS mechanism will continue to propel its application in disease prevention and treatment,providing robust support for the development of novel therapeutic strategies. 展开更多
关键词 liquid-liquid phase separation nuclear condensates transcription regulation
暂未订购 下载PDF
Short-Term Penetration beyond Diffusion Spinodal of a Mixture:Interaction of Liquid-Liquid and Liquid-Vapour Transitions 认领 引用 被引量：1
5
作者 Alexey Melkikh Sergey Rutin +1 位作者 Dmitrii V.Antonov Pavel Skripov 《Frontiers in Heat and Mass Transfer》 EI CAS 2025年第3期721-737,共17页
The article considers a relaxation of the water/polypropylene glycol-425 solution with a lower critical solution temperature(LCST)following its pulsed superheating concerning liquid-liquid and liquid-vapor equilibrium... The article considers a relaxation of the water/polypropylene glycol-425 solution with a lower critical solution temperature(LCST)following its pulsed superheating concerning liquid-liquid and liquid-vapor equilibrium lines,as well as the liquid-liquid spinodal.Superheating was performed using the pulsed heat generation method in a micro-sized wire probe.The main heating mode was the constant(over the pulse length)power mode.Characteristic heating rates ranged from 0.05×105 to 2×105 K/s,while the degree of superheating concerning the spinodal was up to 200 K.The temperature of spontaneous boiling-up and the amplitude of the corresponding signal were monitored as functions of the heating rate set by the power value.The results demonstrate an example of the interaction of liquidliquid and liquid-vapor phase transitions,as well as the spinodal decomposition of a solution with LCST against the background of its unstable states.We proposed a physical model to explain the minimum spontaneous boiling-up temperature revealed within a certain range of heating rates,which is not typical of completely miscible solutions.Further research will focus on establishing a general criterion for the possibility of spinodal decomposition of such solutions under the conditions of rapid heating. 展开更多
关键词 Pulse heating wire probe binary mixture liquid-liquid(diffusion)spinodal spinodal decomposition spontaneous boiling-up
暂未订购 下载PDF
Growth behavior of heavy metal sulfide particles:A comparison between gas-liquid and liquid-liquid sulfidation 认领 引用
6
作者 Chunxue Li Meiqing Shi +5 位作者 Qingzhu Li Jiahui Wu Xu Yan Qingwei Wang Zhang Lin Liyuan Chai 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第8期615-623,共9页
Sulfide precipitation is an effective method for treating acidic heavy metal wastewater.However,the process often generates tiny particles with poor settling performance.The factors and mechanisms influencing particle... Sulfide precipitation is an effective method for treating acidic heavy metal wastewater.However,the process often generates tiny particles with poor settling performance.The factors and mechanisms influencing particle size and settling performance remain unclear.In this study,the growth behavior of CuS particles generated by two sulfide precipitation methods,gas-liquid and liquid-liquid sulfidation,was investigated.The effects of acidity,sulfur-to-copper molar ratio,and temperature on particle size were analyzed.The results showed that increasing the temperature had an adverse effect on CuS particle growth.Additionally,we found that acidity and sulfur-to-copper molar ratio had a more significant impact on particle growth in the liquid-liquid sulfidation system than in the gas-liquid sulfidation system.Based on supersaturation calculations and XPS analysis,it is found that particle growth in gas-liquid sulfidation systems is mainly influenced by supersaturation,while particle growth in liquid-liquid sulfidation systems is mainly affected by surface charge.This study provides valuable insights into the factors that influence particle growth in sulfide precipitation and can inform the development of strategies to improve the effective precipitation of sulfide nanoparticles in acidic wastewater. 展开更多
关键词 Sulfide precipitation Liquid-liquid sulfidation Gas-liquid sulfidation Supersaturation Surface charge Particle growth
暂未订购 下载PDF
Liquid-Liquid Phase Separation in Hereditary Hearing Loss 认领 引用
7
作者 Kefan Tao Yanjun Zong +3 位作者 Xiaozhou Liu Xinyu Shi Zhengdong Zhao Yu Sun 《Neuroscience Bulletin》 SCIE CAS CSCD 2025年第10期1888-1900,共13页
Hearing loss is one of the most prevalent sensory disorders affecting the human nervous system.Liquid–liquid phase separation(LLPS)is a physiological process that facilitates the reversible and dynamic assembly of bi... Hearing loss is one of the most prevalent sensory disorders affecting the human nervous system.Liquid–liquid phase separation(LLPS)is a physiological process that facilitates the reversible and dynamic assembly of biomolecular condensates.Increasing evidence suggests that LLPS plays a significant role in the pathogenesis of hereditary hearing loss.Nevertheless,there is a conspicuous lack of systematic investigations exploring the impact of LLPS abnormalities on the etiology of hereditary hearing loss.In this review,we examine the mechanisms by which dysfunctions in LLPS contribute to hereditary hearing loss,specifically focusing on its effects on mechanoelectrical transduction in hair bundles,transcriptional regulation,post-transcriptional modifications,the actin cytoskeleton,ion homeostasis within the inner ear,and energy and redox homeostasis.Furthermore,we evaluate the considerable potential of targeting LLPS as a therapeutic approach for hearing loss and propose innovative perspectives on LLPS that may guide future research initiatives in the field of auditory disorders. 展开更多
关键词 Liquid-liquid phase separation Hereditary hearing loss Usher syndrome Ankle link complex Posttranscriptional modifcations
暂未订购 下载PDF
Ionic liquid based dispersive liquid-liquid microextraction of aromatic amines in water samples 认领 引用 被引量：16
8
作者 Yun Chang Fan Zheng Liang Hu +2 位作者 Mei Lan Chen Chao Shen Tu Yan Zhu 《Chinese Chemical Letters》 SCIE CAS 2008年第8期985-987,共3页
In this work, a new microextraction method termed ionic liquid based dispersive liquid-liquid microextraction （IL-DLLME） was demonstrated for the extraction of 2-methylaniline, 4-chloroaniline, 1-naphthylamine and 4... In this work, a new microextraction method termed ionic liquid based dispersive liquid-liquid microextraction （IL-DLLME） was demonstrated for the extraction of 2-methylaniline, 4-chloroaniline, 1-naphthylamine and 4-aminobiphenyl in aqueous matrices. After extraction the ionic liquid （IL） phase was injected directly into the high performance liquid chromatography （HPLC） system for determination. Some parameters that might affect the extraction efficiency were optimized. Under the optimum conditions, good linear relationship, sensitivity and reproducibility were obtained. The limits of detection （LOD, S/N = 3） for the four analytes were in the range of 0.45-2.6 μg L^-1. The relative standard deviations （R.S.D., n = 6） were in the range of 6.2-9.8%. This method was applied for the analysis of the real water samples. The recoveries ranged from 93.4 to 106.4%. The main advantages of the method are high speed, high recovery, good repeatability and volatile organic solvent-free. 展开更多
关键词 Ionic liquid （IL） Dispersive liquid-liquid microextraction （DLLME） High performance liquid chromatography （HPLC） Aromatic amines
暂未订购 下载PDF
Study on liquid-liquid bimetal composite casting hammers 认领 引用 被引量：11
9
作者 Rong Shoufan Zhou Haitao +3 位作者 ZhuYongchang Wang Junfa Yao Jia Li Chunhong 《China Foundry》 SCIE CAS 2014年第5期412-417,共6页
Crusher hammers for the mineral processing industry must meet the demands of both high wear resistance at the hammer head and high impact toughness at the hammer handle. The crusher hammers made of Hadfield steel have... Crusher hammers for the mineral processing industry must meet the demands of both high wear resistance at the hammer head and high impact toughness at the hammer handle. The crusher hammers made of Hadfield steel have typical y low service life of less than 40 hours. To solve the problem, a kind of bimetal crusher hammers made of high chromium cast iron （HCCI） and low al oy steel （LAS） has been successful y developed by using liquid-liquid composite casting. The microstructure and composite interface bonding was analyzed using optical microscope, SEM, EDX and XRD. Micrographs indicate that the composite interface is metal urgical y bonded with a zigzag shape across the boundary and without unbound region or void. After heat treatment, the composite hammers have shown excellent properties. The hardness of HCCI is at least 63 HRC and its αk is greater than 3.5 J？cm-2; the hardness of LAS is greater than 35 HRC and its αk is no less than 80 J？cm-2. Diffusion of elements takes place at the interface and forms a transition region. The micro hardness increases from LAS to the interface and then to HCCI. Wear comparison was made separately between the bimetal composite hammer and a Hadfield steel hammer in two quarries of Jilin province and Liaoning province. The results showed that the liquid-liquid bimetal composite hammers did not have the fal ing off of hammer head or impact fracture phenomenon, and their service life was 3.75 times as long as that of the Hadfield steel hammers. 展开更多
关键词 hammer liquid-liquid composite casting bimetal interfacial microstructure
暂未订购 下载PDF
Novel method for the determination of five carbamate pesticides in water samples by dispersive liquid-liquid microextraction combined with high performance liquid chromatography 认领 引用 被引量：11
10
作者 Zhi Mei Liu Xiao Huan Zang +2 位作者 Wei Hua Liu Chun Wang Zhi Wang 《Chinese Chemical Letters》 SCIE CAS 2009年第2期213-216,共4页
A novel method for the determination of five carbamate pesticides(metolcarb,carbofuran,carbaryl,isoprocard and diethofencard)in water samples was developed by dispersive liquid-liquid microextraction(DLLME)coupled wit... A novel method for the determination of five carbamate pesticides(metolcarb,carbofuran,carbaryl,isoprocard and diethofencard)in water samples was developed by dispersive liquid-liquid microextraction(DLLME)coupled with high performance liquid chromatography-diode array detector(HPLC-DAD).Some experimental parameters that influence the extraction efficiency were studied and optimized to obtain the best extraction results.Under the optimum conditions for the method,the calibration curve was linear in the concentration range from 5 to 1000 ng mL^-1 for all the five carbamate pesticides,with the correlation coefficients(r^2)varying from 0.9984 to 0.9994.Good enrichment factors were achieved ranging from 80 to 177-fold,depending on the compound.The limits of detection(LODs)(S/N=3)were ranged from 0.1 to 0.5 ng mL^-1.The method has been successfully applied to the analysis of the pesticide residues in environmental water samples. 展开更多
关键词 Carbamate pesticides High performance liquid chromatography Diode array detection Dispersive liquid-liquid microextraction Water samples
暂未订购 下载PDF
HCWCI/Carbon Steel Bimetal Liner by Liquid-Liquid Compound Lost Foam Casting 认领 引用 被引量：13
11
作者 XIAO Xiao-feng YE Sheng-ping +1 位作者 YIN Wei-xin XUE Qiong 《Journal of Iron and Steel Research International》 SCIE CAS CSCD 2012年第10期13-19,共7页
Impact,friction and corrosion from the grinding balls and the grinding medium during the mineral processing result in liner breakage.Liner,made from Hadfield steel or alloyed steel,could not have served in wet grindin... Impact,friction and corrosion from the grinding balls and the grinding medium during the mineral processing result in liner breakage.Liner,made from Hadfield steel or alloyed steel,could not have served in wet grinding environment for more than ten months.Composite liner,made from HCWCI(high Cr white cast iron)and carbon steel,has been developed successfully with liquid-liquid composing process based on LFC(lost foam casting).The microstructure of composite was analyzed with optical microscope,SEM(scanning electron microscope)/EDX energy-dispersive X-ray and XRD(X-ray diffraction).According to micrograph,the combination region of two metals was staggered like dogtooth,no mixtures occurred between two liquid metals,and its interface presented excellent metallurgical bonding state.The results of mechanical property test show that,the hardness of HRC,the fracture toughness,and the bending strength are more than 61,16.5 J/cm2 and 1600 MPa,respectively.Comparison between liners made from bimetal composite and alloyed steel has also been investigated in industrial hematite ball mill.The results of eight months test in wet grinding environment prove that the service life of bimetal composite liner is three times as long as that of one made from alloyed steel. 展开更多
关键词 composite liner bimetal liquid-liquid compound composite interface lost foam casting high Cr white cast iron
暂未订购 下载PDF
High Cr white cast iron/carbon steel bimetal liner by lost foam casting with liquid-liquid composite process 认领 引用 被引量：11
12
作者 Xiao Xiaofeng Ye Shengping +2 位作者 YinWeixin Zhou Xiaoguang Xue Qiong 《China Foundry》 SCIE CAS 2012年第2期136-142,共7页
Liners in wet ball mill for mineral processing industry must bear abrasive wear and corrosive wear, and consequently, the service life of the liner made from traditional materials, such as Hadfield steel and alloyed s... Liners in wet ball mill for mineral processing industry must bear abrasive wear and corrosive wear, and consequently, the service life of the liner made from traditional materials, such as Hadfield steel and alloyed steels, is typically less than ten months. Bimetal liner, made from high Cr white cast iron and carbon steel, has been successfully developed by using liquid-liquid composite lost foam casting process. The microstructure and interface of the composite were analyzed using optical microscope, SEM, EDX and XRD. Micrographs indicate that the boundary of bimetal combination regions is staggered like dogtooth, two liquid metals are not mixed, and the interface presents excellent metallurgical bonding state. After heat treatment, the composite liner specimens have shown excellent properties, including hardness 〉 61 HRC, fracture toughness ak 〉16.5 J.cm2 and bending strength 〉1,600 MPa. Wear comparison was made between the bimetal composite liner and alloyed steel liner in an industrial hematite ball mill of WISCO, and the results of eight-month test in wet grinding environment have proved that the service life of the bimetal composite liner is three times as long as that of the alloyed steel liner. 展开更多
关键词 bimetal liner liquid-liquid composite process lost foam casting high Cr white cast iron
暂未订购 下载PDF
Ice Slurry Formation in a Cocurrent Liquid-Liquid Flow 认领 引用 被引量：10
13
作者 彭正标 袁竹林 +1 位作者 梁坤峰 蔡杰 《Chinese Journal of Chemical Engineering》 SCIE EI CAS 2008年第4期552-557,共6页
A new technique for ice slurry production was explored. Multiple small water-drops were formed in another immiscible chilled liquid by a single-nozzled atomizer and frozen in the fluidized bed by direct contact heat t... A new technique for ice slurry production was explored. Multiple small water-drops were formed in another immiscible chilled liquid by a single-nozzled atomizer and frozen in the fluidized bed by direct contact heat transfer. Experiments were conducted to investigate the dynamic behaviors of the ice crystal making system. The results demonstrate that the ice crystals could be produced continuously and stably in the vertical bed with the circulating coolant of initial temperature below -5℃. The size distribution of the ice crystals appears non-uniform, but is more similar and more uniform at lower oil flow rate. The mean ice crystal size rests seriously with the jet velocity and the oil flow rate. It decreases with decreasing the oil flow rate, and reaches the maximum at an intermediate jet velocity at about 16.5 m.s y. The ice crystal size is also closely related to the phenomenon of drop-coalescing, which can be alleviated considerably by reducing the flow rate or lowering the temperature of the carrier oil. However, optimization of liquid-liquid atomization is a more effective approach to produce fine ice crystals of desired size. 展开更多
关键词 ice slurry drop-coalescing ice crystal size distribution liquid-liquid atomization
暂未订购 下载PDF
CFD-PBM coupled modeling of the liquid-liquid dispersion characteristics and structure optimization for Kenics static mixer 认领 引用 被引量：6
14
作者 Junhai Deng Shilin Lan +4 位作者 Juchang Wu Shenghua Du Weidong Liu Luchang Han Yefeng Zhou 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第6期173-188,共16页
Kenics static mixers(KSM)are extensively used in industrial mixing-reaction processes by virtue of high mixing efficiency,low power homogenization and easy continuous production.Resolving liquid droplet size and its d... Kenics static mixers(KSM)are extensively used in industrial mixing-reaction processes by virtue of high mixing efficiency,low power homogenization and easy continuous production.Resolving liquid droplet size and its distribution and thus revealing the dispersion characteristics are of great significance for structural optimization and process intensification in the KSM.In this work,a computational fluid dynamics-population balance model(CFD-PBM)coupled method is employed to systematically investigate the effects of operating conditions and structural parameters of KSM on droplet size and its distribution,to further reveal the liquid-liquid dispersion characteristics.Results indicate that higher Reynolds numbers or higher dispersed phase volume fractions increase energy dissipation,reducing Sauter mean diameter(SMD)of dispersed phase droplets and with a shift in droplet size distribution(DSD)towards smaller size.Smaller aspect ratios,greater blade twist and assembly angles amplify shear rate,leading to smaller droplet size and a narrower DSD in the smaller range.The degree of impact exerted by the aspect ratio is notably greater.Notably,mixing elements with different spin enhance shear and stretching efficiency.Compared to the same spin,SMD becomes 3.7-5.8 times smaller in the smaller size range with a significantly narrower distribution.Taking into account the pressure drop and efficiency in a comprehensive manner,optimized structural parameters for the mixing element encompass an aspect ratio of 1-1.5,a blade twist angle of 180°,an assembly angle of 90°,and interlaced assembly of adjacent elements with different spin.This work provides vital theoretical underpinning and future reference for enhancing KSM performance. 展开更多
关键词 CFD Population balance Liquid-liquid dispersion Kenics static mixer
暂未订购 下载PDF
Numerical study on the morphology of a liquid-liquid pintle injector element primary breakup spray 认领 引用 被引量：14
15
作者 Rui ZHOU Chi-bing SHEN Xuan JIN 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2020年第8期684-694,共11页
Primary breakup in a liquid-liquid pintle injector element at different radial jet velocities is investigated to elucidate the impingement morphology,the formation of primary breakup spray half cone angle,the pressure... Primary breakup in a liquid-liquid pintle injector element at different radial jet velocities is investigated to elucidate the impingement morphology,the formation of primary breakup spray half cone angle,the pressure distribution,the liquid diameter distribution,and the liquid velocity distribution.With a sufficient mesh resolution,the liquid morphology can be captured in a physically sound way.A mushroom tip is triggered by a larger radial jet velocity and breakup happens at the tip edge first.Different kinds of ligament breakup patterns due to aerodynamic force and surface tension are captured on the axial sheet.A high pressure core is spotted at the impinging point region.A larger radial jet velocity can feed more disturbances into the impinging point and the axial sheet,generate stronger vortices to promote the breakup process at a longer distance,and form a larger spray half cone angle.Because of the re-collision phenomenon the axial sheet diameter does not decrease monotonically.The inner rim on the axial sheet shows a larger diameter magnitude and a lower velocity magnitude due to surface tension.This paper is expected to provide a reference for the optimum design of a liquid-liquid pintle injector. 展开更多
关键词 Pintle injector element Liquid-liquid impingement Primary breakup Volume of fluid-to-discrete phase model(VOF-to-DPM)simulation Adaptive mesh refinement(AMR)method
暂未订购 下载PDF
A novel method for the determination of trace copper in cereals by dispersive liquid-liquid microextraction based on solidification of floating organic drop coupled with flame atomic absorption spectrometry 认领 引用 被引量：5
16
作者 Chun Xia Wu Qiu Hua Wu +1 位作者 Chun Wang Zhi Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2011年第4期473-476,共4页
A novel,simple,rapid,efficient and environment-friendly method for the determination of trace copper in cereal samples was developed by using dispersive liquid-liquid microextraction based on solidification of floatin... A novel,simple,rapid,efficient and environment-friendly method for the determination of trace copper in cereal samples was developed by using dispersive liquid-liquid microextraction based on solidification of floating organic drop(DLLME-SFO)followed by flame atomic absorption spectrometry.In the DLLME-SFO,copper was complexed with 8-hydroxy quinoline and extracted into a small volume of 1-dodecanol,which is of low density,low toxicity and proper melting point near room temperature.The experimental parameters affecting the extraction efficiency were investigated and optimized.Under the optimum conditions,the calibration graph exhibited linearity over the range of 0.5—500 ng/mL with the correlation coefficient(r)of 0.9996.The enrichment factor was 122 and the limit of detection was 0.1 ng/mL.The method was applied to the determination of copper in the complex matrix samples such as rice and millet with the recoveries for the spiked samples at 5.0 and 10.0 u,g/g falling in the range of 92.0-98.0%and the relative standard deviation of 3.9-5.7%. 展开更多
关键词 Dispersive liquid-liquid microextraction based on solidification of floating organic droplet Flame atomic absorption spectrometry Copper Cereal samples
暂未订购 下载PDF
Prediction of Pressure Gradient and Holdup in Small Eoetvoes Number Liquid-Liquid Segregated Flow 认领 引用 被引量：3
17
作者 刘夷平 张华 +1 位作者 王淑华 王经 《Chinese Journal of Chemical Engineering》 SCIE EI CAS 2008年第2期184-191,共8页
The segregated flow pattern, which occurs in a 26.1 mm diameter, horizontal, stainless steel test section, is investigated. Pressure gradient and in situ phase distribution data were obtained for different combination... The segregated flow pattern, which occurs in a 26.1 mm diameter, horizontal, stainless steel test section, is investigated. Pressure gradient and in situ phase distribution data were obtained for different combinations of phase superficial velocities ranging from 0.05 m.s^-1 to 0,96 m.s^-1. For the current small Eoetvoes number liquid-liquid system （EOD=4.77）, the dominant effect of interfacial tension and wall-wetting properties of the liquids over the gravity is considered. The approach introduces the closure relationship for the case of turbulent flow m a rough pipe, and attempts to modify the two-fluid model to account for the curved interface. In present flow rates range, wave amplitudes were found small, while interfacial mixing was observed. An adjustable definition for hydraulic diame- ters of two fluids and interfacial friction factor is adopted. The predicted pressure gradient and in situ phase distribution data have been compared with present experimental data and those reported in the literature. 展开更多
关键词 two-fluid model pressure gradient holdup liquid-liquid flow interfacial shear
暂未订购 下载PDF
An Experimental Study of Liquid-Liquid Microflow Pattern Maps Accompanied with Mass Transfer 认领 引用 被引量：11
18
作者 SHAO Huawei LÜYangcheng +1 位作者 WANG Kai LUO Guangsheng 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2012年第1期18-26,共9页
This paper presents the experimental results of liquid-liquid microflows in a coaxial microfluidic device with mass transfer.Three working systems were n-butanol + phosphoric acid(PA) + water,methyl isobutyl ketone(MI... This paper presents the experimental results of liquid-liquid microflows in a coaxial microfluidic device with mass transfer.Three working systems were n-butanol + phosphoric acid(PA) + water,methyl isobutyl ketone(MIBK) + PA + water,30% kerosene in tri-n-butylphosphate(TBP) + PA + water.The direction and intensity of mass transfer were adjusted by adding PA in one of two phases mutual saturated in advance.When PA transferred from the organic phase to the aqueous phase,tiny aqueous droplets may generate inside the organic phase by mass transfer inducement to form a new W/O/W flow pattern directly on some special cases.Once the PA concentration was very high,violent Marangoni effect could be observed to throw part of organic phase out of droplets as tail.The interphase transfer of PA could expand the jetting flow region,in particular for systems with low or medium inter-facial tension and when the mass transfer direction was from the aqueous phase to the organic phase. 展开更多
关键词 mass transfer flow pattern liquid-liquid system microflows
暂未订购 下载PDF
Dispersive Liquid-liquid Microextraction Combined with High-performance Liquid Chromatography for the Determination of Clozapine and Chlorpromazine in Urine 认领 引用 被引量：6
19
作者 陈静 熊朝梅 +1 位作者 阮金兰 苏邹 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2011年第2期277-284,共8页
A simple method has been proposed for the determination of clozapine （CLZ） and chlorpromazine （CPZ） in human urine by dispersive liquid-liquid microextraction （DLLME） in combination with high-performance liquid ... A simple method has been proposed for the determination of clozapine （CLZ） and chlorpromazine （CPZ） in human urine by dispersive liquid-liquid microextraction （DLLME） in combination with high-performance liquid chromatography-ultraviolet detector （HPLC-UV）. All important variables influencing the extraction efficiency, such as pH, types of the extraction solvent and the disperser solvent and their volume, ionic strength and centrifugation time were investigated and optimized. Under the optimal conditions, the limit of detection （LODs） and quantification （LOQs） of the method were 13 and 39 ng/mL for CLZ, and 2 and 6 ng/mL for CPZ, respectively. The relative standard deviations （RSDs） of the targets were less than 5.1% （C=0.100 μg/mL, n=9）. Good linear behaviors over the tested concentration ranges were obtained with the values of R20.999 for the targets. The absolute extraction efficiencies of CLZ and CPZ from the spiked blank urine samples were 98.3% and 97.8%, respectively. The applicability of the technique was validated by analyzing urine samples and the mean recoveries for spiked urine samples ranged from 93.3% to 105.0%. The method was successfully applied for the determination of CLZ and CPZ in real human urine. 展开更多
关键词 dispersive liquid-liquid microextraction clozapine chlorpromazine high-performance liquid chromatography human urine
暂未订购 下载PDF
Improved determination of salicylaldoxime in water samples by liquid-liquid extraction followed by high performance liquid chromatographic analysis 认领 引用 被引量：3
20
作者 KONG Qian BAI Xiu-zhi +2 位作者 LIN Hui-ju LI Hai-pu YANG Zhao-guang 《Journal of Central South University》 SCIE EI CAS CSCD 2018年第4期701-708,共8页
For the determination of salicylaldoxime in environmental water samples,a stable and rapid method with low detection was proposed and established,based on the liquid-liquid extraction-high performance liquid chromatog... For the determination of salicylaldoxime in environmental water samples,a stable and rapid method with low detection was proposed and established,based on the liquid-liquid extraction-high performance liquid chromatography with ultraviolet detector.Parameters including extraction solvent,ionic strength,solution pH,and extraction pattern were discussed for the optimal quantification of salicylaldoxime-spiked water.When the described method was applied to four spiked water samples,the obtained average extraction recovery rate was found between 87%–107%and relative standard deviation was below 6%.At the same time,good linear relationships were observed for spiked water samples from 0.01 to 10μg/mL(R2=0.9993).In addition,the detection limit of salicylaldoxime was revealed between 0.003–0.008μg/mL,which is two orders of magnitude lower than previously reported results.Thus,the presented method may be advantageous for the high-efficiency determination of salicylaldoxime in water samples. 展开更多
关键词 high-performance liquid chromatography liquid-liquid extraction salicylaldoxime
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 250 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈