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miR-944靶向调控MARCH7对非小细胞肺癌细胞增殖、凋亡及顺铂耐药的机制研究 认领 引用
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作者 吴映南 薛明月 +1 位作者 崔文佳 鲁小敏 《河北医药》 CAS 2026年第7期1081-1085,共5页
目的探究miR-944靶向调控MARCH7对非小细胞肺癌细胞增殖、凋亡及顺铂耐药的机制研究。方法将肺癌A549细胞常规培养后用DDP浓度梯度法建立DDP耐药细胞株,完成后设立miR-944 mimics组(将miR-944 mimics转染至细胞株中)、MARCH7 siRNA组(将... 目的探究miR-944靶向调控MARCH7对非小细胞肺癌细胞增殖、凋亡及顺铂耐药的机制研究。方法将肺癌A549细胞常规培养后用DDP浓度梯度法建立DDP耐药细胞株,完成后设立miR-944 mimics组(将miR-944 mimics转染至细胞株中)、MARCH7 siRNA组(将MARCH7 siRNA转染至细胞株中)、miR-944 mimics+MARCH7 siRNA组(将miR-944 mimics与MARCH7 siRNA共同转染至细胞株中)。采用CCK-8法检测细胞增殖情况,采用TUNEL法检测细胞凋亡,对顺铂耐药机制进行检测并用线性回归法计算药物半抑制浓度(IC50)值,采用荧光素酶测定系统检测miR-944与MARCH7靶向关系,采用PCR检测miR-944与MARCH7表达。结果与对照组比较,miR-944 mimics组、MARCH7 siRNA组及miR-944 mimics+MARCH7 siRNA组细胞中的miR-944、细胞凋亡率升高,MARCH7、IC50及24、48、72 h增殖率降低(P0.05)。双荧光素酶报告实验结果显示,miR-944 mimics转染MARCH7 siRNA后MARCH7明显降低(P0.05),提示MARCH7与miR-944可能存在靶向以及负调控的关系。结论在非小细胞肺癌中,升高miR-944及敲低MARCH7可能有助于抑制癌细胞增殖、促进其凋亡,同时还可能对改善耐药状态具有一定积极作用。 展开更多
关键词 miR-944 MARCH7 非小细胞肺癌 细胞增殖 凋亡 顺铂耐药
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基于改进March算法的闪存测试方法与系统研究 认领 引用
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作者 王军防 霍毅 +3 位作者 吴尚书 殷宇朝 周明 王营营 《自动化应用》 2026年第14期102-104,共3页
提出一种基于改进March算法的闪存测试方法与系统,旨在解决传统测试方法中动态故障漏检率高、硬件适配性差与故障分析效率低的问题。通过引入动态奇偶校验写入策略、双向遍历耦合测试机制与状态保持验证,改进March算法将动态故障漏检率... 提出一种基于改进March算法的闪存测试方法与系统,旨在解决传统测试方法中动态故障漏检率高、硬件适配性差与故障分析效率低的问题。通过引入动态奇偶校验写入策略、双向遍历耦合测试机制与状态保持验证,改进March算法将动态故障漏检率从20%降至5%以下,测试周期缩短40%。系统采用总线通信方式与可视化交互设计,支持NAND和NOR闪存多协议适配,将故障定位精度提升至95%以上。实验结果表明,该系统对电荷泄漏、邻位干扰等新型故障具有较强的检测能力,为高密度闪存可靠性验证提供了系统性解决方案。 展开更多
关键词 闪存测试 March算法 总线通信 可视化分析
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MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD 认领 引用 被引量：1
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作者 Hao Feng Jiaxin Niu +2 位作者 Zhi Chen Guobin Yang Guohua Yuan 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期126-136,共11页
Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated R... Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated RING finger protein 2(March2) is the highest among all March family members,with an increasing trend during odontoblast differentiation.In mouse incisors and molars,MARCH2 is moderately expressed in the undifferentiated dental papilla cells and strongly expressed in the odontoblasts.Knockdown and overexpression experiments demonstrate that MARCH2 inhibits odontoblastic differentiation of mouse dental papilla cells(mDPCs).Additionally,both March2 deficient mice and mice with odontoblast specific knockdown of March2 exhibit the phenotype of increased dentin thickness,accelerated dentin deposition as well as elevated expression levels of odontoblast markers compared with control littermates.Therefore,MARCH2 plays an inhibitory role in odontoblast differentiation.Mechanistically,MARCH2 interacts with protein tyrosine phosphatase receptor delta(PTPRD) and facilitates its K27-linked polyubiquitination and subsequent degradation,which is dependent on the ligase activity of MARCH2.The presence of MARCH2promotes the translocation of PTPRD from the cell membrane to the lysosome,thereby enhancing its degradation via the lysosomal pathway.Further experiments show that knockdown of endogenous Ptprd impairs odontoblastic differentiation of mDPCs.Ptprd and March2 double knockdown in mDPCs apparently reversed the enhanced odontoblastic differentiation by knockdown of March2 alone,indicating that MARCH2 inhibits odontoblastic differentiation by promoting PTPRD degradation.This study unveils a novel mechanism where an E3 ubiquitin ligase regulates odontoblast differentiation through post-translational modification of a membrane protein,highlighting a promising direction for future exploration. 展开更多
关键词 membrane protein degradation undifferentiated dental papilla cells dental hard tissues polyubiquitination dental hard tissuesis Ptprd March mouse incisors
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The Enduring Echo of the Long March:Toward a Shared Future 认领 引用
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《China Today》 2026年第7期22-23,共2页
Ninety years after the Chinese Workers’and Peasants’Red Army accomplished its epic strategic relocation(1934-1936),the Long March spirit continues to illuminate China’s modernization drive–and its broader global g... Ninety years after the Chinese Workers’and Peasants’Red Army accomplished its epic strategic relocation(1934-1936),the Long March spirit continues to illuminate China’s modernization drive–and its broader global governance endeavors.The relevance of the Long March has long since transcended national boundaries.What the Long March forged was not only a fighting force but a way of moving through history:discipline tested by adversity,unity chosen over disruption,and the belief that justice isn’t bestowed from a higher authority but by mobilizing ordinary people. 展开更多
关键词 Ordinary People Discipline Global Governance Modernization Unity Justice long march Long March Spirit
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Construction,Protection,and Utilization Strategies of Red Cultural Heritage Corridor in the Jiangxi Section of the Red Army's Long March 认领 引用
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作者 Feiping CHEN Junhai LIU +4 位作者 Jinyang YUAN Hua LI Hao LIU Jianping ZHANG Yikui LIANG 《Meteorological and Environmental Research》 2026年第1期37-44,共8页
In this paper,the Jiangxi section of the red army's long march is taken as the research object to construct a red cultural heritage corridor.Introducing the theory of heritage corridor,on the basis of its hierarch... In this paper,the Jiangxi section of the red army's long march is taken as the research object to construct a red cultural heritage corridor.Introducing the theory of heritage corridor,on the basis of its hierarchical decomposition and comparative judgment,a hierarchy model of the red cultural heritage corridor resource is established.The comprehensive scores of each factor are obtained through expert scoring,and the overall pattern of red army corridor is constructed as"ring-shape-point".New ideas for protection and utilization as well as protection implementation measures are proposed,and the spiritual and cultural connotations of long march in Jiangxi are fully explored.This could help the social and economic development of the areas along the long march of red army in Jiangxi,and promote the integrated utilization and coordinated development of resources in the red cultural heritage corridor region. 展开更多
关键词 Red cultural heritage Jiangxi section of the red army's long march Construction and protection strategies for heritage corridors Analytic hierarchy process
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基于改进Marching Cubes算法的舰船齿轮三维建模 认领 引用
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作者 陈玉红 史培行 《舰船科学技术》 北大核心 2026年第9期185-189,共5页
为精确捕捉齿轮复杂几何特征,避免细节信息丢失,设计了基于改进Marching Cubes的舰船齿轮三维建模方法。通过工业计算机断层扫描技术,采集舰船齿轮的二维切片图像,堆叠得到齿轮体数据;采用结合齿轮几何参数的区域生长法,分割体数据,得... 为精确捕捉齿轮复杂几何特征,避免细节信息丢失,设计了基于改进Marching Cubes的舰船齿轮三维建模方法。通过工业计算机断层扫描技术,采集舰船齿轮的二维切片图像,堆叠得到齿轮体数据;采用结合齿轮几何参数的区域生长法,分割体数据,得到齿轮区域的体数据;利用最近邻法,改进Marching Cubes算法,在齿轮体数据中精准捕捉齿轮几何特征,确定等值点并绘制三角面片,通过整合三角面片完成舰船齿轮三维建模,避免细节信息丢失。实验证明:该方法可有效分割舰船齿轮体数据,在不同体素分辨率下,该方法齿轮体数据分割的重叠面积变化率均较小,最大值约为9%,具备较优的齿轮体数据分割效果;在不同舰船齿轮二维切片层厚下,该方法三维建模的Hausdorff距离均较小,即三维建模精度较高。 展开更多
关键词 改进Marching Cubes 舰船齿轮 三维建模 区域生长法 最近邻法
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The New Long March Spirit Lives On 认领 引用
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作者 MARK H.LEVINE 《China Today》 2026年第7期34-36,共3页
The Long March is not confined to history.Its essence and vitality are seen in China every day.I first heard of the Long March in the 1960s,as a college student in the United States.Like many Westerners,at the time I ... The Long March is not confined to history.Its essence and vitality are seen in China every day.I first heard of the Long March in the 1960s,as a college student in the United States.Like many Westerners,at the time I understood it as a distant,heroic tale from China’s past–a military relocation transformed into legendary status.It was only after reading Edgar Snow’s Red Star Over China in the mid-1970s that I began to grasp its deeper meaning:not merely a story of survival,but a testament to endurance,collective sacrifice,and unwavering belief in the face of impossible odds. 展开更多
关键词 Spirit Essence History China long march United States College Student Vitality
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Gansu:90 Years after the Long March 认领 引用
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作者 Rafael Henrique Zerbetto 《China Report ASEAN》 2026年第7期46-48,共3页
Ninety years ago,the Long March,an epic trek spanning more than 10,000 kilometers across China,came to an end.More than a strategic operation undertaken by China's Red Army between 1934 and 1936,it played a pivota... Ninety years ago,the Long March,an epic trek spanning more than 10,000 kilometers across China,came to an end.More than a strategic operation undertaken by China's Red Army between 1934 and 1936,it played a pivotal role in shaping modern China.To understand the legacy of the Long March,we embarked on a journey to Gansu Province in northwest China to visit key historical sites and explore the social and economic development of those areas since the arrival of the Red Army. 展开更多
关键词 social economic development historical sites economic development gansu province social development long march
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The Long March Spirit:Enduring Legacy,Modern Drive,and Global Vision 认领 引用
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作者 KEITH BENNETT 《China Today》 2026年第7期30-33,共4页
The enduring spirit of perseverance,unity,and people-centered commitment embodied in the Long March continues to inspire China’s modernization,international cooperation,and vision of building a community with a share... The enduring spirit of perseverance,unity,and people-centered commitment embodied in the Long March continues to inspire China’s modernization,international cooperation,and vision of building a community with a shared future for humanity. 展开更多
关键词 unity building community shared future humanity global vision enduring legacy modern drive perseverance long march people centered commitment
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Evaluation of Red Cultural Heritage Corridor Resources in the Jiangxi Section of the Red Army’s Long March Based on AHP Method 认领 引用
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作者 CHEN Feiping LIU Junhai +4 位作者 LI Sihao LI Hua HUANG Hui ZHANG Jianping LIU Hao 《Journal of Landscape Research》 2026年第1期27-32,共6页
The literature analysis,data collection,and on-site exploration are conducted on 128 heritage nodes in the three historical event routes with linear characteristics at the Jiangxi section of the red army's long ma... The literature analysis,data collection,and on-site exploration are conducted on 128 heritage nodes in the three historical event routes with linear characteristics at the Jiangxi section of the red army's long march.Combining their characteristics,protection status,heritage value,etc.,a system framework for evaluating heritage corridor resources is constructed by integrating the analytic hierarchy process and Delphi method.On this basis,the weight values corresponding to each evaluation factor are accurately determined,and the comprehensive score of heritage resources is calculated based on the Rosenberg-Fishbein mathematical model formula.The login route,distribution area,protection level,and protection status are analyzed,providing a solid theoretical basis and scientific support for the scientific construction and effective protection of the red cultural heritage corridor in the Jiangxi section of the red army’s long march. 展开更多
关键词 Red army’s long march Jiangxi Heritage corridor Red cultural heritage Heritage resource evaluation
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E3泛素连接酶MARCH1抗病毒感染研究进展 认领 引用
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作者 于长清 彭永刚 +5 位作者 张贺 李明翔 徐超 张斌 先元华 汤艳东 《中国动物传染病学报》 CAS 北大核心 2025年第2期220-226,共7页
E3泛素连接酶对细胞内蛋白质命运具有重要调控作用。宿主细胞E3泛素连接酶MARCH1蛋白是RING家族成员,在调控宿主细胞免疫识别和免疫应答中具有重要作用。近期研究结果表明,MARCH1在宿主细胞抗病毒感染中发挥重要角色。其抗病毒感染主要... E3泛素连接酶对细胞内蛋白质命运具有重要调控作用。宿主细胞E3泛素连接酶MARCH1蛋白是RING家族成员,在调控宿主细胞免疫识别和免疫应答中具有重要作用。近期研究结果表明,MARCH1在宿主细胞抗病毒感染中发挥重要角色。其抗病毒感染主要有两种模式。一方面,MARCH1通过诱导病毒蛋白质发生泛素化并靶向细胞内途径降解;另一方面,MARCH1可将病毒囊膜糖蛋白滞留在细胞内,进而阻断病毒的组装和感染循环。本文将对宿主MARCH1分子的两种抗病毒感染模式进行阐述,为后续抗病毒研究工作提供参考。 展开更多
关键词 MARCH1 天然免疫 抗病毒 囊膜糖蛋白 弗林蛋白酶
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利用MarchingCubes算法的塔身垂直度激光雷达检验方法 认领 引用 被引量：2
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作者 周命端 覃钰涵 +4 位作者 孟庆龙 徐翔 刘明华 宋峤 王俊杰 《测绘科学》 CSCD 北大核心 2025年第3期123-131,共9页
鉴于移动立方体算法在医学成像、计算机图形学、工程建模等领域被广泛应用,顾及激光雷达检验法具有诸多优点,提出了一种新的利用MarchingCubes算法的塔身垂直度激光雷达检验方法。实验选取施工现场某型号塔式起重机塔身进行测试,采用激... 鉴于移动立方体算法在医学成像、计算机图形学、工程建模等领域被广泛应用,顾及激光雷达检验法具有诸多优点,提出了一种新的利用MarchingCubes算法的塔身垂直度激光雷达检验方法。实验选取施工现场某型号塔式起重机塔身进行测试,采用激光雷达扫描采集塔身标准节原始点云数据,经预处理后获取塔身标准节有效高精度点云数据;给出塔身标准节横向切段立方体点云分割策略,利用MarchingCubes算法提取塔身标准节横向切段立方体点云轮廓线,并求解其体中心点坐标;运用最小二乘法拟合体中心点所在空间直线,计算其方向向量,并在站心空间坐标系下分别与x轴和z轴进行向量运算,获得塔身轴心线倾斜方位角、倾斜角和塔身垂直度。结果表明:采用本文方法设计5种策略方案获得的塔身垂直度中数值为1.80‰,与传统的经纬仪检验法结果为3.02‰基本吻合。本文为塔身垂直度无损检验提供一种高精度激光雷达算法。 展开更多
关键词 激光雷达检验法 经纬仪检验法 移动立方体算法 点云数据 塔身垂直度
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MARCH9介导磷酸酶RPTPα的泛素化降解 认领 引用
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作者 张宇琴 依力夏提·艾合买提 +2 位作者 王艳丽 阳志 黄建 《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2025年第8期957-968,共12页
目的·探讨E3泛素连接酶膜相关锌指蛋白9(membrane-associated RING-CH 9,MARCH9)调控受体型蛋白质酪氨酸磷酸酶α(receptor protein tyrosine phosphatase alpha,RPTPα)泛素化修饰的分子机制及其生物学功能。方法·采用Wester... 目的·探讨E3泛素连接酶膜相关锌指蛋白9(membrane-associated RING-CH 9,MARCH9)调控受体型蛋白质酪氨酸磷酸酶α(receptor protein tyrosine phosphatase alpha,RPTPα)泛素化修饰的分子机制及其生物学功能。方法·采用Western blotting鉴定RPTPα的泛素化修饰类型及MARCH9对其泛素化水平的调控作用;比较MARCH9野生型、MARCH9酶活突变体(MARCH9 S198A或MARCH9-HC/CC),以及shRNA介导的内源MARCH9敲低对RPTPα蛋白稳定性的影响;利用蛋白酶体抑制剂MG132、自噬抑制剂3-MA和溶酶体抑制剂氯喹(chloroquine,CQ)鉴定MARCH9介导的RPTPα泛素化降解类型;探究43℃热激促进RPTPα蛋白降解的可能机制;利用慢病毒载体构建MARCH9单敲低(H1299-sh MARCH9)及MARCH9/RPTPα双敲低(H1299-sh MARCH9-sh RPTPα)的肺癌稳转细胞株,通过CCK-8细胞增殖、平板克隆形成和软琼脂克隆形成实验,评估MARCH9或RPTPα对肺癌细胞增殖与集落形成能力的影响;通过血管拟态形成实验和划痕实验检测MARCH9或RPTPα对肺癌细胞侵袭、迁移能力的影响;建立裸鼠皮下移植瘤模型评价MARCH9或RPTPα对肺癌细胞体内成瘤能力的影响;通过生物信息学方法比较MARCH9和RPTPα在肺癌患者中的表达差异与预后相关性。结果·RPTPα主要发生K63连接型多聚泛素化修饰,E3泛素连接酶MARCH9过表达显著增强其泛素化水平;过表达野生型MARCH9而非酶活突变体能显著降低RPTPα蛋白稳定性,而shRNA敲低内源MARCH9后RPTPα蛋白水平又会明显上升;CQ而非MG132或3-MA处理能增加RPTPα蛋白稳定性,提示MARCH9主要介导RPTPα的泛素化-溶酶体降解途径;43℃热激可以特异增强MARCH9-RPTPα相互作用并促进RPTPα蛋白降解。功能实验显示:与对照H1299细胞相比,H1299-sh MARCH9细胞的RPTPα蛋白水平升高,细胞增殖速率加快,克隆形成和细胞侵袭能力均明显增强,裸鼠中成瘤能力也明显增强,而双敲低MARCH9/RPTPα的稳转细胞株又能逆转上述表型(均P<0.05)。生物信息学分析肺癌患者相关数据,显示RPTPα高表达与肺癌患者不良预后及肿瘤转移呈正相关,而MARCH9则为负相关。结论·MARCH9介导了磷酸酶RPTPα的K63型泛素化依赖的溶酶体降解过程。这一发现为开发靶向RPTPα的肿瘤治疗策略提供了新的依据。 展开更多
关键词 蛋白质酪氨酸磷酸酶RPTPα E3泛素连接酶MARCH9 泛素化 热激 肺癌
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E3泛素连接酶March6抑制成牙本质细胞分化以及牙本质生成 认领 引用
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作者 冯豪 袁国华 《口腔医学研究》 CAS CSCD 北大核心 2025年第8期657-663,共7页
目的:明确膜相关的RING-CH型E3泛素连接酶6(membrane-associated RING finger protein 6, March6)在成牙本质细胞分化以及牙本质生成中的作用。方法:采用免疫组织化学染色(immunohistochemistry, IHC)分析不同发育阶段小鼠牙齿切片,分析... 目的:明确膜相关的RING-CH型E3泛素连接酶6(membrane-associated RING finger protein 6, March6)在成牙本质细胞分化以及牙本质生成中的作用。方法:采用免疫组织化学染色(immunohistochemistry, IHC)分析不同发育阶段小鼠牙齿切片,分析March6的时空表达特征。体外敲低小鼠牙乳头细胞(mouse dental papilla cells, mDPCs)中的March6,并进行矿化诱导,分别使用实时定量PCR、Western bolt、碱性磷酸酶(alkaline phosphatase, ALP)染色以及茜素红染色,评估March6对mDPCs成牙本质细胞向分化潜能的影响。将Prx1cre与March6flox/flox小鼠配繁,获得牙齿间充质中特异性敲除March6的小鼠(March6 cKO,Prx1cre;March6flox/flox)。通过IHC验证March6被特异性敲除。随后,对出生后10 d的March6 cKO及其同窝对照小鼠的下颌行切片苏木素-伊红染色、显微CT(micro-computed tomography, Micro-CT)观察,以确定March6在体内对牙本质生成的影响。结果:March6在胚胎时期小鼠牙齿间充质中表达水平较低,而在成牙本质细胞形成后,March6在成牙本质细胞中高表达。体外敲低mDPCs中的March6,并诱导其向成牙本质细胞分化,牙本质基质蛋白1(dentin matrix protein 1,Dmp1)和牙本质涎磷蛋白(dentin sialophosphoprotein, Dspp)的mRNA以及蛋白水平相较于对照显著上调。同时,细胞ALP活性和钙化结节生成能力在敲低组中也明显增强。组织学形态观察以及Micro-CT分析结果显示,March6 cKO小鼠的牙本质层相较于同窝对照明显增厚。结论:E3泛素连接酶March6对成牙本质细胞分化以及牙本质生成发挥抑制作用。 展开更多
关键词 March6 成牙本质细胞分化 牙本质生成 基因敲除
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过表达MARCH2抑制自噬促进肝细胞癌HUH7细胞的生长 认领 引用
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作者 夏丹 韦志永 《临床医学进展》 2025年第5期2371-2380,共10页
目的:探讨过表达MARCH2对肝细胞癌HUH7细胞自噬水平和生长的影响及其机制。方法:MTS和EDU检测MARCH2过表达的肝细胞癌HUH7细胞的生长情况。流式细胞术检测MARCH2过表达的肝细胞癌HUH7细胞凋亡、细胞周期的情况。Western blot和激光共聚... 目的:探讨过表达MARCH2对肝细胞癌HUH7细胞自噬水平和生长的影响及其机制。方法:MTS和EDU检测MARCH2过表达的肝细胞癌HUH7细胞的生长情况。流式细胞术检测MARCH2过表达的肝细胞癌HUH7细胞凋亡、细胞周期的情况。Western blot和激光共聚焦法检测MARCH2过表达的肝细胞癌HUH7细胞自噬水平。结果:MTS和EDU检测表明,MARCH2的过表达促进了肝细胞癌HUH7的生长。流式细胞术检测表明,MARCH2过表达对肝细胞癌HUH7细胞凋亡和细胞周期没有明显影响。进一步的实验表明,MARCH2过表达损害了肝细胞癌HUH7的自噬。用常见的自噬诱导剂雷帕霉素挽救自噬可以使肝细胞癌HUH7的增殖率恢复到控制水平。结论:我们的数据表明,MARCH2通过抑制自噬在肿瘤发展过程中起着至关重要的作用。因此,MARCH2是一种有前景的肿瘤治疗新靶点。Aims: To investigate the effects and mechanisms of overexpression of MARCH2 on autophagy levels and growth of hepatocellular carcinoma HUH7 cells. Methods: MTS and EDU were used to detect the growth of MARCH2 overexpressing hepatocellular carcinoma HUH7 cells. Flow cytometry was used to detect apoptosis and cell cycle in MARCH2 overexpressing hepatocellular carcinoma HUH7 cells. Western blot and laser confocal microscopy were used to detect the autophagy levels in MARCH2 overexpressing HUH7 hepatocellular carcinoma cells. Results: In this study, MTS and EDU assays showed that the overexpression of MARCH2 promoted the growth of hepatocellular carcinoma HUH7 cells. Flow cytometry detection illustrated that MARCH2 overexpression had no obvious effect on the hepatocellular carcinoma HUH7 cell apoptosis and cell cycle. Further experiments displayed that MARCH2 overexpression impaired the autophagy of hepatocellular carcinoma HUH7 cells. Rescued autophagy with the common autophagy inducer rapamycin can bring the proliferation rate of hepatocellular carcinoma HUH7 cells back to the control level. Conclusions: Our data indicates that MARCH2 plays an essential role in the progression of tumor development through inhibiting autophagy. Therefore, MARCH2 is an attractive novel target for tumor therapy. 展开更多
关键词 MARCH2 肝细胞癌HUH7细胞 自噬 凋亡 细胞周期
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Research on Optimizing the Construction of the Long March National Cultural Park from the Perspective of Cultural Route Heritage Protection 认领 引用
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作者 Wang Yiping 《Contemporary Social Sciences》 2023年第4期59-68,共10页
The idea of cultural route heritage protection expands the protection theory for world cultural heritage.The Long March route carries the prominent characteristic of cultural route heritage.By actively building the Lo... The idea of cultural route heritage protection expands the protection theory for world cultural heritage.The Long March route carries the prominent characteristic of cultural route heritage.By actively building the Long March National Cultural Park,China has strengthened the overall protection and integrated utilization of the Long March cultural heritage,upgraded the hardware facilities for exhibition,and investigated ways to protect cultural route heritage with Chinese characteristics.During the construction of the Park,it is necessary to draw on the concept and norms of the cultural route heritage protection,optimize the construction approach,and make the construction of the Park more in line with the linear cultural characteristics of Long March heritage.Specifically,it is proposed to improve the Long March cultural route heritage protection system oriented towards“authenticity”protection,to deeply tap and interpret the prominent universal worth of the Long March route,augmenting the international dissemination of the Long March culture in an innovative way,and realizing a more scientific and effective protection and utilization of Long March cultural resources. 展开更多
关键词 cultural routes Long March route Long March National Cultural Park
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一种基于存储器内建自测试的新型动态March算法设计 认领 引用 被引量：10
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作者 蔡志匡 余昊杰 +2 位作者 杨航 王子轩 郭宇锋 《电子与信息学报》 EI CAS CSCD 北大核心 2023年第9期3420-3429,共10页
存储器作为片上系统(SoC)中最大和最重要的模块之一,它的稳定性和可靠性关乎着整个芯片能否正常工作。为了提高存储器的测试效率,该文提出一种新型动态March算法——Dynamic-RAWC。相比经典的March RAW算法,Dynamic-RAWC算法有着更良好... 存储器作为片上系统(SoC)中最大和最重要的模块之一,它的稳定性和可靠性关乎着整个芯片能否正常工作。为了提高存储器的测试效率,该文提出一种新型动态March算法——Dynamic-RAWC。相比经典的March RAW算法,Dynamic-RAWC算法有着更良好的故障检测效果:动态故障覆盖率提高了31.3%。这个可观的效果得益于所提算法以经典的March RAW算法为基础进行优化,融入了Hammer,March C+算法的测试元素和一些新的测试元素。不同于普通March型算法的固定元素,所提算法支持用户自定义算法的执行顺序以适应不同的故障检测需求,能够动态地控制算法元素,在时间复杂度和故障覆盖率之间进行调整从而达到良好的平衡。 展开更多
关键词 存储器内建自测试 March算法 动态故障 故障覆盖率
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Fast Marching Method for Microseismic Source Location in Cavern-Containing Rockmass: Performance Analysis and Engineering Application 认领 引用 被引量：26
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作者 Ruochen Jiang Feng Dai +1 位作者 Yi Liu Ang Li 《Engineering》 SCIE EI CAS CSCD 2021年第7期1023-1034,共12页
Microseismic(MS)event locations are vital aspect of MS monitoring technology used to delineate the damage zone inside the surrounding rock mass.However,complex geological conditions can impose significantly adverse ef... Microseismic(MS)event locations are vital aspect of MS monitoring technology used to delineate the damage zone inside the surrounding rock mass.However,complex geological conditions can impose significantly adverse effects on the final location results.To achieve a high-accuracy location in a complex cavern-containing structure,this study develops an MS location method using the fast marching method(FMM)with a second-order difference approach(FMM2).Based on the established velocity model with three-dimensional(3D)discrete grids,the realization of the MS location can be achieved by searching the minimum residual between the theoretical and actual first arrival times.Moreover,based on the calculation results of FMM2,the propagation paths from the MS sources to MS sensors can be obtained using the linear interpolation approach and the Runge–Kutta method.These methods were validated through a series of numerical experiments.In addition,our proposed method was applied to locate the recorded blasting and MS events that occurred during the excavation period of the underground caverns at the Houziyan hydropower station.The location results of the blasting activities show that our method can effectively reduce the location error compared with the results based on the uniform velocity model.Furthermore,the obtained MS location was verified through the occurrence of shotcrete fractures and spalling,and the monitoring results of the in-situ multipoint extensometer.Our proposed method can offer a more accurate rock fracture location and facilitate the delineation of damage zones inside the surrounding rock mass. 展开更多
关键词 Fast marching method Microseismic event location Cavern-containing complex rock mass Runge-Kutta method
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Marching Cubes算法研究现状 认领 引用 被引量：26
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作者 孙伟 张彩明 杨兴强 《计算机辅助设计与图形学学报》 EI 北大核心 2007年第7期947-952,共6页
对现有的Marching Cubes改进算法从拓扑结构二义性、提高逼近精度、算法的时间和空间效率3个方面进行综述,对每一类改进算法进行新的分类,并对各类算法的实验结果进行比较.
关键词 Marching Cubes 等值面抽取 拓扑二义性 精度 效率
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Marching Cubes改进算法及其气象三维模拟 认领 引用 被引量：6
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作者 毕硕本 陆源 +2 位作者 曾晓文 路明月 张永华 《系统仿真学报》 CAS CSCD 北大核心 2017年第7期1405-1410,1418,共6页
用三等分体元边界的方法取代了原始Marching Cubes算法中通过线性插值获得等值面与体元交点的方法,该方法不仅解决了线性插值不适用于气象数据模拟的问题,还有效地减少了等值面绘制过程中生成的三角面片的数量,在减少冗余提高绘制速度... 用三等分体元边界的方法取代了原始Marching Cubes算法中通过线性插值获得等值面与体元交点的方法,该方法不仅解决了线性插值不适用于气象数据模拟的问题,还有效地减少了等值面绘制过程中生成的三角面片的数量,在减少冗余提高绘制速度的同时也进一步提高了等值面图像绘制的质量。将改进之后的Marching Cubes算法应用在对气象模式数据即WRF数据的等值面模拟中,在图像绘制速度和绘制质量上均取得了不错的实验效果。 展开更多
关键词 Marching Cubes算法 等值面 三维模拟 WRF
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