为提升旋转机械在强背景噪声及复杂工业环境下的故障诊断性能,提出了一种融合软阈值机制与元自适应开关(meta-activate or not, meta-ACON)结构的创新性诊断方法。该方法首次在meta-ACON中引入可学习软阈值机制,构建具有自适应软阈值与...为提升旋转机械在强背景噪声及复杂工业环境下的故障诊断性能,提出了一种融合软阈值机制与元自适应开关(meta-activate or not, meta-ACON)结构的创新性诊断方法。该方法首次在meta-ACON中引入可学习软阈值机制,构建具有自适应软阈值与动态非线性激活双重特性的软阈值元自适应开关(soft-thresholding meta-ACON,STMA)激活函数。为实现参数的动态调节,基于注意力机制设计元学习模块STMA-FilterUnit,根据输入特征自适应学习滤波阈值、激活非线性参数和通道响应权重。在此基础上,将STMA-FilterUnit嵌入残差深度可分离卷积中,构建多分支残差收缩卷积网络,该网络采用并行双通道残差连接实现多尺度特征提取,利用STMA-FilterUnit进行噪声特征的抑制、关键特征的增强及跨尺度特征的融合。在凯斯西储大学轴承数据集和东南大学的齿轮箱数据集上的试验结果表明,该方法在低信噪比和变载荷条件下故障诊断准确率与泛化性能均优于对比组模型,验证了STMA在复杂工业环境中抑制干扰与提取判别性特征的有效性。展开更多
Objectives To directly compare the efficacy of individual reminiscence therapy(IRT)and group reminiscence therapy(GRT)for alleviating depressive symptoms in older adults,and to evaluate their effects on secondary outc...Objectives To directly compare the efficacy of individual reminiscence therapy(IRT)and group reminiscence therapy(GRT)for alleviating depressive symptoms in older adults,and to evaluate their effects on secondary outcomes,including anxiety,cognitive function,life satisfaction,and quality of life.Methods A systematic review and network meta-analysis(NMA)was conducted.Eleven Chinese and English databases were searched from inception to December 1,2025.Randomized controlled trials(RCTs)comparing IRT or GRT against a medication control group(MCG),a non-medication control group(NCG),or each other were included.Risk of bias(RoB)was assessed using the RoB 2 tool,and evidence certainty was evaluated using the Grading of Recommendations Assessment,Development and Evaluation(GRADE)framework.Pairwise and network meta-analyses were performed,with comparisons further stratified by baseline depression severity(mild,moderate,severe).Treatment rankings were based on the surface under the cumulative ranking(SUCRA)statistic.Subgroup analyses were conducted to examine potential effect modifiers,including intervention format,baseline depression severity,control type,intervention duration,session frequency,total sessions,cumulative intervention time,geographical region,setting,and provider qualification.Results Twenty RCTs with 1,633 participants were included.For depression,both IRT and GRT were significantly superior to MCG and NCG,with no statistically significant difference between the two modalities overall(SMD=−0.03;95%CI:−0.49,0.42).Severity-stratified analysis revealed that GRT had the highest probability of being optimal for mild depression(SUCRA=92.5%),while IRT ranked highest for moderate(SUCRA=80.6%)and severe depression(SUCRA=84.5%).For secondary outcomes,IRT was superior to GRT for reducing anxiety and improving cognitive function,whereas GRT was more effective for enhancing life satisfaction.Subgroup analyses showed no significant moderating effects for any of the examined variables(all P>0.05).Conclusions Both IRT and GRT are effective for depression in older adults,with no statistically significant difference between them.GRT may be preferred for mild depression,while IRT may be more suitable for moderate-to-severe depression.IRT shows additional benefits for anxiety and cognition,whereas GRT excels in improving life satisfaction.These findings support a personalized,severity-informed approach to selecting RT delivery formats in clinical practice.展开更多
Objectives This study aimed to compare and rank the efficiency of various devices used for intubation fixation in patients undergoing orotracheal intubation in the ICU.Methods A comprehensive search of pertinent datab...Objectives This study aimed to compare and rank the efficiency of various devices used for intubation fixation in patients undergoing orotracheal intubation in the ICU.Methods A comprehensive search of pertinent databases was conducted,encompassing all available records from their inception until March 2025.The databases included PubMed,Embase,Web of Science,the Cochrane Library,China Knowledge Resource Integrated Database(CNKI),Wanfang Databases,Chinese Biomedical Databases disc(CBM disc),and VIP Database.The review concentrated on randomized controlled trials(RCTs)that examined various intubation fixation devices for patients with tracheostomy in the ICU.A network meta-analysis was then performed to compare and rank the efficacy of these devices,with catheter displacement,facial pressure injuries,and patient-reported pain as the primary outcomes,by evaluating the odds ratios(ORs)and rank probabilities.Results This network meta-analysis synthesized data from 16 RCTs assessing five different intubation fixation devices.No significant differences were found among devices regarding catheter displacement or facial pressure injuries.However,hybrid fixation(using adhesive tapes and straps)provided significantly better pain relief than dental pad fixation(OR=16.27,95%CI:3.56,74.30)and had the highest ranking probability(78%)for minimizing pain.Conclusions While no single device was superior across all outcomes,hybrid fixation demonstrated a significant advantage in reducing patient pain.Future high-quality RCTs with standardized outcomes are needed to strengthen these findings and inform clinical guidelines.展开更多
Objective To explore possible healing advantages of probiotics in controlling Alzheimer’s diseese(AD).Methods Conducting an extensive evaluation of probiotics’healing effects,encompassing various facets and perspect...Objective To explore possible healing advantages of probiotics in controlling Alzheimer’s diseese(AD).Methods Conducting an extensive evaluation of probiotics’healing effects,encompassing various facets and perspectives.We conducted an extensive search across 9 databases with no language restrictions,spanning from the inception of research to March 7,2025,to identify randomized controlled studies examining the impact of probiotic therapy on.A meta-analysis was then performed using random-effects models to determine the standardized mean difference(SMD),I2 statistic,and 95%confidence interval(CI).Results The study eventually incorporated eight randomized controlled trials(RCT),with 261 individuals in probiotic cohort and 256 in the placebo group.Probiotics significantly improved cognitive function,promoted total anti-oxidant capacity and mitigated the pro-oxidant process and inflammation.Conclusion The significance of probiotic supplements lies in their ability to enhance cognitive abilities in individuals with cognitive deficits,offering both theoretical underpinnings and actionable advice for using probiotics clinically in AD treatment.展开更多
Objectives:This systematic review and meta-analysis aimed to identify and synthesize the factors correlated with posttraumatic growth(PTG)in patients with colorectal cancer(CRC).Methods:PubMed,Web of Science,Embase,Ps...Objectives:This systematic review and meta-analysis aimed to identify and synthesize the factors correlated with posttraumatic growth(PTG)in patients with colorectal cancer(CRC).Methods:PubMed,Web of Science,Embase,PsycINFO,CINAHL,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang database,China Science and Technology Journal Database(VIP)and SinoMed were searched for studies that reported data on the correlated factors associated with PTG in patients with CRC from inception to September 3,2024.The methodological quality of the included studies was assessed via the Agency for Healthcare Research and Quality(AHRQ)methodology checklist and the Newcastle-Ottawa Scale(NOS).Pearson correlation coefficient(r)was utilized to indicate effect size.Meta-analysis was conducted in R Studio.Results:Thirty-one eligible studies encompassing 6,400 participants were included in this review.Correlated factors were identified to be significantly associated with PTG in patients with CRC including demographic factors:residential area(r=0.13),marital status(r=0.10),employment status(r=0.18),education level(r=0.19),income level(r=0.16);disease-related factors:time since surgery(r=0.17),stoma-related complications(r=0.14),health-promoting behavior(r=0.46),and sexual function(r=0.17);psychosocial factors:confrontation coping(r=0.68),avoidance coping(r=-0.65),deliberate rumination(r=0.56),social support(r=0.47),family function(r=0.50),resilience(r=0.53),selfefficacy(r=0.91),self-compassion(r=-0.32),psychosocial adjustment(r=0.39),gratitude(r=0.45),stigma(r=-0.65),self-perceived burden(r=-0.31),fear of cancer recurrence(r=-0.45);and quality of life(r=0.32).Conclusions:This meta-analysis identified 23 factors associated with PTG in CRC patients.Medical workers can combine those relevant factors from the perspective of positive psychology,further explore the occurrence and development mechanism of PTG,and establish targeted interventions to promote PTG.展开更多
Objectives A systematic review and network meta-analysis was conducted to evaluate the effectiveness of different childbirth positions in reducing the duration of the second stage of labor,providing evidence-based ins...Objectives A systematic review and network meta-analysis was conducted to evaluate the effectiveness of different childbirth positions in reducing the duration of the second stage of labor,providing evidence-based insights for obstetric institutions to guide interventions related to childbirth positions.Methods A comprehensive literature search was conducted in databases,including PubMed,Web of Science,the Cochrane Library,Embase,Wanfang Databases,China National Knowledge Infrastructure Databases(CNKI),China Science and Technology Journal Database(CSTJ),and China Biology Medicine disc(CBMdisc)to identify studies on the effectiveness of different childbirth positions in reducing the duration of the second stage of labor.The search included randomized controlled trials published from database inception to September 30,2024.The Cochrane risk-of-bias tool was used to assess the quality of the studies.Two independent reviewers screened the literature,extracted data,and evaluated study quality.Subsequently,a network meta-analysis was performed using STATA software.The study protocol has been registered in PROSPERO(CRD42023428217).Results This study analyzed data from 25 randomized controlled trials involving 9,844 women.The findings indicated that in comparison to lithotomy position,free position(MD=20.53,95%CI[11.38,29.68])and upright position(MD=−24.13,95%CI[−42.94,-5.32])were found to be superior in reducing the duration of the second stage of labor.Free position outperformed kneeling position(MD=21.48,95%CI[4.67,38.28])and squatting position(MD=23.43,95%CI[1.88,44.97]);upright position was superior to kneeling position(MD=−25.08,95%CI[−46.93,−3.22]);semirecumbent position surpassed squatting position(MD=19.71,95%CI[2.05,37.38]);and upright position was also superior to squatting position(MD=−27.03,95%CI[−51.48,−2.57]).According to the surface under the cumulative ranking curve(SUCRA),the upright position emerged as the most effective for reducing the duration of the second stage of labor(87.4%),followed by free position(81.1%),semirecumbent position(70.0%),and lateral position(62.3%).Conclusion These findings offer valuable insights for midwifery practice and help inform future research directions.Considering the limitations of this review,more larger-scale,multicenter randomized controlled trials are warranted to further evaluate the relative effectiveness of different childbirth positions in reducing the duration of the second stage of labor.展开更多
Objective Systematically integrate nurses’experience with“Internet Nursing Service”to analysis the nurses’experiences with“Internet Nursing Service”,and to provide a theoretical reference for formulating a more ...Objective Systematically integrate nurses’experience with“Internet Nursing Service”to analysis the nurses’experiences with“Internet Nursing Service”,and to provide a theoretical reference for formulating a more rational“Internet Nursing Service”model.Methods A systematic search in PubMed,Embase,Web of Science,the Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and Chinese Biomedical Literature Database was conducted to collect qualitative research on nurses’experiences with“Internet Nursing Service,”with a retrieval time limit from December 2019 to June 2024.Qualitative meta-synthesis was performed through line-by-line coding of relevant quotes,organization of codes into descriptive themes,and development of analytical themes.Results A total of 19 studies were included,one study was rated as Grade A in quality evaluation,and the remaining studies were rated as Grade B.Collectively synthesized into three integrated results:Harvest and growth,Difficulties and challenges,and Expectations and support.Harvest and growth,include 1)manifestation of self-value,2)enhancing nursing capabilities,3)optimizing nursing resources;Difficulties and challenges,include 1)lack of safety guarantee,2)role conflict;Expectations and support include,1)expectation for professional knowledge and skill training,2)expectations for service platform optimization,3)expectation for reasonable charges,4)expectation for related policy support.Conclusion“Internet Nursing Service”model benefits both nurses and patients,but still full of challenges.It aids in the decentralization of medical resources.Management departments still need to encourage nurses to actively invest in“Internet Nursing Service”while ensuring their safety and interests.展开更多
Objectives:This study aimed to assess the impact of exercise rehabilitation during the vulnerable period on cardiac recovery(CR)outcomes in patients with acute decompensated heart failure(ADHF).Methods:Multiple databa...Objectives:This study aimed to assess the impact of exercise rehabilitation during the vulnerable period on cardiac recovery(CR)outcomes in patients with acute decompensated heart failure(ADHF).Methods:Multiple databases including PubMed,Web of Science,Embase,the Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Chinese Science and Technology Periodical Database(VIP),Wanfang database,SinoMed,ClinicalTrials.gov,and American Heart Association(AHA)and European Society of Cardiology(ESC)were searched for RCTs on exercise rehabilitation in ADHF patients’vulnerable period from inception to April 2,2025.The risk of bias was assessed with Cochrane Risk of Bias 2.0,and data were analyzed in RevMan 5.3.Results:A total of seven RCTs involving 946 patients were included.The results demonstrated that exercise rehabilitation training during the vulnerable period in patients with ADHF significantly increased the 6-min walk test distance(6-MWTD)(SMD=0.37;95%CI:0.09,0.65;P=0.01),short physical performance battery(SPPB)score(MD=1.26;95%CI:0.82,1.70;P<0.001)and peak oxygen consumption(VO2peak)(SMD=1.43;95%CI:0.53,2.34;P=0.002),improved quality of life(QoL)(SMD=0.85;95%CI:0.07,1.64,P=0.03),reduced depression score(MD=-0.73;95%CI:1.27,-0.18;P=0.009),frailty(MD=-0.22;95%CI:-0.48,0.05;P=0.11),and decreased 6-month all-cause readmission(OR=0.67;95%CI:0.49,0.91;P=0.01).However,no statistically significantdifferences were observed between the two groups in left ventricular ejection fraction(LVEF)(MD=0.96;95%CI:-1.84,3.77;P=0.50),6-month heart failure(HF)-related readmission(OR=1.01;95%CI:0.66,1.53;P=0.98),and all-cause mortality(OR=0.63;95%CI:0.18,2.24;P=0.47).There were no adverse events reported.Conclusions:Exercise rehabilitation during the vulnerable phase improves exercise tolerance,QoL,and depressive symptoms while reducing 6-month all-cause readmissions in ADHF patients,with no reported adverse events.Although trends toward improved LVEF,HF-related readmissions,and all-cause mortality were observed.Large-scale,high-quality studies are warranted to explore individualized responses and long-term outcomes.展开更多
Objectives:Workplace violence is a serious issue in healthcare settings.Nurses are particularly vulnerable,and such violence significantly impacts their professional lives,leading to decreased productivity and care qu...Objectives:Workplace violence is a serious issue in healthcare settings.Nurses are particularly vulnerable,and such violence significantly impacts their professional lives,leading to decreased productivity and care quality.We aimed to estimate the pooled prevalence of workplace violence against nurses through systematic review and meta-analysis in Saudi Arabia.Methods:Databases were searched for articles published in English from 2013 to 2023,including PubMed,Web of Science,Science Direct,Medline,Emerald,Wiley,and ProQuest.The quality of the included studies was rigorously assessed using the Joanna Briggs Institute(JBI)critical appraisal tools.Meta-analysis was conducted using Comprehensive Meta-Analysis software.Subgroup analysis,metaregression,and publication bias tests were performed.Results:The pooled prevalence of workplace violence among nurses in Saudi Arabia was 61.8%(95%CI:45.8%-75.6%).Subgroup analysis showed the highest prevalence of workplace violence in studies conducted before 2020 at 69.7%(95%CI:42.0%-88.0%)and 2020-2023 at 57.0%(95%Cl:35.6%-76.1%);in the western region at 90.2%(95%CI:70.2%-97.3%);among female nurses at 81.8%(95%Cl:66.9%-90.9%);with patient relatives as perpetrators at 70.8%(95%Cl:46.4%-87.2%);during afternoon shifts at 78.5%(95%CI:64.4%-88.1%);for verbal abuse at 54.9%(95%Cl:31.3%-76.6%);and in the intensive care unit at 68.1%(95%Cl:28.1%-92.1%).Meta-regression analysis revealed that the night shift significantly contributed to heterogeneity.The funnel plot and Egger's regression test(P=0.647)indicated no significant publication bias.Conclusions:This meta-analysis showed the estimate of workplace violence against nurses in Saudi Arabia is 61.8%.Nursing managers and health policymakers should implement targeted interventions to prevent workplace violence,especially among female nurses,during afternoon shifts,in intensive care units,and in the western region of Saudi Arabia.展开更多
This study aimed to systematically evaluate the clinical efficacy of combining wax therapy with conventional drug therapy for rheumatoid arthritis(RA)and to provide evidence supporting its clinical application.A compr...This study aimed to systematically evaluate the clinical efficacy of combining wax therapy with conventional drug therapy for rheumatoid arthritis(RA)and to provide evidence supporting its clinical application.A comprehensive search was conducted across PubMed,Cochrane Library,China Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI),Wanfang,and VIP databases from their inception to May 2024.Randomized controlled trials(RCTs)investigating the combination of wax therapy and conventional drug therapy for RA were included in the analysis.Statistical analysis was performed using Review Manager 5.3 software.Nine studies,encompassing a total of 843 patients,were included.The results demonstrated that the combination therapy significantly improved clinical efficacy compared to conventional drug therapy alone[RR=1.22,95%CI(1.11,1.34)].Moreover,the combination therapy led to notable improvements in DAS 28 scores[MD=-0.90,95%CI(-1.23,-0.57),P<0.00001],VAS scores[MD=-0.90,95%CI(-1.13,-0.66),P<0.00001],reduction in joint tenderness[MD=-1.27,95%CI(-1.81,-0.72),P<0.00001],decreased duration of morning stiffness[MD=-25.47,95%CI(-34.33,-16.61),P<0.00001],and lowered C-reactive protein levels[MD=-6.29,95%CI(-12.02,-0.57),P<0.05].In conclusion,wax therapy combined with conventional anti-rheumatic drugs significantly enhanced the clinical outcomes for RA patients by alleviating symptoms,reducing joint pain and morning stiffness,and decreasing inflammatory markers more effectively than conventional drug therapy alone.展开更多
Objective This systematic review and meta-analysis aimed to identify the main factors influencing the public’s willingness to participate in out-of-hospital emergency care.Methods Studies were searched in online data...Objective This systematic review and meta-analysis aimed to identify the main factors influencing the public’s willingness to participate in out-of-hospital emergency care.Methods Studies were searched in online databases,including PubMed,Embase,Web of Science,and the Cochrane Library.The articles included in this review were published from inception to July 31,2024.The Iain Crombie assessment tool was used to assess study quality.Meta-analysis was performed using RevMan(version 5.4)software.The review protocol has been registered with PROSPERO(CRD42024570491).Results A total of 1,434 research articles were initially identified,among which 18 were incorporated into this study,and all of the included studies were cross-sectional.Meta-analysis results demonstrated that gender(male;OR=1.37,95%CI:1.28–1.47),profession(healthcare provider;OR=0.17,95%CI:0.06–0.47),knowledge and skill level(OR=1.63,95%CI:1.25–2.11),willingness to undergo training(OR=2.68,95%CI:1.89–3.79),interest in first aid(OR=2.08,95%CI:1.60–2.69),previous training(OR=2.14,95%CI:1.49–3.08),and previous first-aid experience(OR=1.70,95%CI:1.37–2.11)were the principal influencing factors of the public’s willingness to engage in out-of-hospital cardiopulmonary resuscitation.Conclusion Demographic factors,knowledge,belief,and behavior are crucial in influencing public emergency decision-making.Medical personnel could create specialized training programs based on relevant factors to enhance the public's willingness to engage in out-of-hospital CPR.展开更多
摘要为提升旋转机械在强背景噪声及复杂工业环境下的故障诊断性能,提出了一种融合软阈值机制与元自适应开关(meta-activate or not, meta-ACON)结构的创新性诊断方法。该方法首次在meta-ACON中引入可学习软阈值机制,构建具有自适应软阈值与动态非线性激活双重特性的软阈值元自适应开关(soft-thresholding meta-ACON,STMA)激活函数。为实现参数的动态调节,基于注意力机制设计元学习模块STMA-FilterUnit,根据输入特征自适应学习滤波阈值、激活非线性参数和通道响应权重。在此基础上,将STMA-FilterUnit嵌入残差深度可分离卷积中,构建多分支残差收缩卷积网络,该网络采用并行双通道残差连接实现多尺度特征提取,利用STMA-FilterUnit进行噪声特征的抑制、关键特征的增强及跨尺度特征的融合。在凯斯西储大学轴承数据集和东南大学的齿轮箱数据集上的试验结果表明,该方法在低信噪比和变载荷条件下故障诊断准确率与泛化性能均优于对比组模型,验证了STMA在复杂工业环境中抑制干扰与提取判别性特征的有效性。
摘要Objectives To directly compare the efficacy of individual reminiscence therapy(IRT)and group reminiscence therapy(GRT)for alleviating depressive symptoms in older adults,and to evaluate their effects on secondary outcomes,including anxiety,cognitive function,life satisfaction,and quality of life.Methods A systematic review and network meta-analysis(NMA)was conducted.Eleven Chinese and English databases were searched from inception to December 1,2025.Randomized controlled trials(RCTs)comparing IRT or GRT against a medication control group(MCG),a non-medication control group(NCG),or each other were included.Risk of bias(RoB)was assessed using the RoB 2 tool,and evidence certainty was evaluated using the Grading of Recommendations Assessment,Development and Evaluation(GRADE)framework.Pairwise and network meta-analyses were performed,with comparisons further stratified by baseline depression severity(mild,moderate,severe).Treatment rankings were based on the surface under the cumulative ranking(SUCRA)statistic.Subgroup analyses were conducted to examine potential effect modifiers,including intervention format,baseline depression severity,control type,intervention duration,session frequency,total sessions,cumulative intervention time,geographical region,setting,and provider qualification.Results Twenty RCTs with 1,633 participants were included.For depression,both IRT and GRT were significantly superior to MCG and NCG,with no statistically significant difference between the two modalities overall(SMD=−0.03;95%CI:−0.49,0.42).Severity-stratified analysis revealed that GRT had the highest probability of being optimal for mild depression(SUCRA=92.5%),while IRT ranked highest for moderate(SUCRA=80.6%)and severe depression(SUCRA=84.5%).For secondary outcomes,IRT was superior to GRT for reducing anxiety and improving cognitive function,whereas GRT was more effective for enhancing life satisfaction.Subgroup analyses showed no significant moderating effects for any of the examined variables(all P>0.05).Conclusions Both IRT and GRT are effective for depression in older adults,with no statistically significant difference between them.GRT may be preferred for mild depression,while IRT may be more suitable for moderate-to-severe depression.IRT shows additional benefits for anxiety and cognition,whereas GRT excels in improving life satisfaction.These findings support a personalized,severity-informed approach to selecting RT delivery formats in clinical practice.
基金funded by the Science Research Foundation of the Chinese Nursing Association[Grant No.ZHKY202304]。
摘要Objectives This study aimed to compare and rank the efficiency of various devices used for intubation fixation in patients undergoing orotracheal intubation in the ICU.Methods A comprehensive search of pertinent databases was conducted,encompassing all available records from their inception until March 2025.The databases included PubMed,Embase,Web of Science,the Cochrane Library,China Knowledge Resource Integrated Database(CNKI),Wanfang Databases,Chinese Biomedical Databases disc(CBM disc),and VIP Database.The review concentrated on randomized controlled trials(RCTs)that examined various intubation fixation devices for patients with tracheostomy in the ICU.A network meta-analysis was then performed to compare and rank the efficacy of these devices,with catheter displacement,facial pressure injuries,and patient-reported pain as the primary outcomes,by evaluating the odds ratios(ORs)and rank probabilities.Results This network meta-analysis synthesized data from 16 RCTs assessing five different intubation fixation devices.No significant differences were found among devices regarding catheter displacement or facial pressure injuries.However,hybrid fixation(using adhesive tapes and straps)provided significantly better pain relief than dental pad fixation(OR=16.27,95%CI:3.56,74.30)and had the highest ranking probability(78%)for minimizing pain.Conclusions While no single device was superior across all outcomes,hybrid fixation demonstrated a significant advantage in reducing patient pain.Future high-quality RCTs with standardized outcomes are needed to strengthen these findings and inform clinical guidelines.
基金Natural Science Foundation of China(82571825)Natural Science Foundation of Hebei Province(Key Project of Joint Funding for Innovative Development of Precision Medicine,H2025206168)+3 种基金Natural Science Foundation of Hebei Province(H2023206266)Industry-University-Research Project of Universities Stationed in Hebei Collaborative with Shijiazhuang(241200073A)Hebei Province International Science and Technology Cooperation Key Project(25292401D)Scientific Research Project of Higher Education Institutions in Hebei Province(CXZX2025007)。
摘要Objective To explore possible healing advantages of probiotics in controlling Alzheimer’s diseese(AD).Methods Conducting an extensive evaluation of probiotics’healing effects,encompassing various facets and perspectives.We conducted an extensive search across 9 databases with no language restrictions,spanning from the inception of research to March 7,2025,to identify randomized controlled studies examining the impact of probiotic therapy on.A meta-analysis was then performed using random-effects models to determine the standardized mean difference(SMD),I2 statistic,and 95%confidence interval(CI).Results The study eventually incorporated eight randomized controlled trials(RCT),with 261 individuals in probiotic cohort and 256 in the placebo group.Probiotics significantly improved cognitive function,promoted total anti-oxidant capacity and mitigated the pro-oxidant process and inflammation.Conclusion The significance of probiotic supplements lies in their ability to enhance cognitive abilities in individuals with cognitive deficits,offering both theoretical underpinnings and actionable advice for using probiotics clinically in AD treatment.
基金supported by the‘Double First-Class’Construction Specialized Discipline Project at Zhejiang University(No HL2024012).
摘要Objectives:This systematic review and meta-analysis aimed to identify and synthesize the factors correlated with posttraumatic growth(PTG)in patients with colorectal cancer(CRC).Methods:PubMed,Web of Science,Embase,PsycINFO,CINAHL,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang database,China Science and Technology Journal Database(VIP)and SinoMed were searched for studies that reported data on the correlated factors associated with PTG in patients with CRC from inception to September 3,2024.The methodological quality of the included studies was assessed via the Agency for Healthcare Research and Quality(AHRQ)methodology checklist and the Newcastle-Ottawa Scale(NOS).Pearson correlation coefficient(r)was utilized to indicate effect size.Meta-analysis was conducted in R Studio.Results:Thirty-one eligible studies encompassing 6,400 participants were included in this review.Correlated factors were identified to be significantly associated with PTG in patients with CRC including demographic factors:residential area(r=0.13),marital status(r=0.10),employment status(r=0.18),education level(r=0.19),income level(r=0.16);disease-related factors:time since surgery(r=0.17),stoma-related complications(r=0.14),health-promoting behavior(r=0.46),and sexual function(r=0.17);psychosocial factors:confrontation coping(r=0.68),avoidance coping(r=-0.65),deliberate rumination(r=0.56),social support(r=0.47),family function(r=0.50),resilience(r=0.53),selfefficacy(r=0.91),self-compassion(r=-0.32),psychosocial adjustment(r=0.39),gratitude(r=0.45),stigma(r=-0.65),self-perceived burden(r=-0.31),fear of cancer recurrence(r=-0.45);and quality of life(r=0.32).Conclusions:This meta-analysis identified 23 factors associated with PTG in CRC patients.Medical workers can combine those relevant factors from the perspective of positive psychology,further explore the occurrence and development mechanism of PTG,and establish targeted interventions to promote PTG.
基金the Obstetrics and Gynecology Hospital of Fudan University for supporting this project。
摘要Objectives A systematic review and network meta-analysis was conducted to evaluate the effectiveness of different childbirth positions in reducing the duration of the second stage of labor,providing evidence-based insights for obstetric institutions to guide interventions related to childbirth positions.Methods A comprehensive literature search was conducted in databases,including PubMed,Web of Science,the Cochrane Library,Embase,Wanfang Databases,China National Knowledge Infrastructure Databases(CNKI),China Science and Technology Journal Database(CSTJ),and China Biology Medicine disc(CBMdisc)to identify studies on the effectiveness of different childbirth positions in reducing the duration of the second stage of labor.The search included randomized controlled trials published from database inception to September 30,2024.The Cochrane risk-of-bias tool was used to assess the quality of the studies.Two independent reviewers screened the literature,extracted data,and evaluated study quality.Subsequently,a network meta-analysis was performed using STATA software.The study protocol has been registered in PROSPERO(CRD42023428217).Results This study analyzed data from 25 randomized controlled trials involving 9,844 women.The findings indicated that in comparison to lithotomy position,free position(MD=20.53,95%CI[11.38,29.68])and upright position(MD=−24.13,95%CI[−42.94,-5.32])were found to be superior in reducing the duration of the second stage of labor.Free position outperformed kneeling position(MD=21.48,95%CI[4.67,38.28])and squatting position(MD=23.43,95%CI[1.88,44.97]);upright position was superior to kneeling position(MD=−25.08,95%CI[−46.93,−3.22]);semirecumbent position surpassed squatting position(MD=19.71,95%CI[2.05,37.38]);and upright position was also superior to squatting position(MD=−27.03,95%CI[−51.48,−2.57]).According to the surface under the cumulative ranking curve(SUCRA),the upright position emerged as the most effective for reducing the duration of the second stage of labor(87.4%),followed by free position(81.1%),semirecumbent position(70.0%),and lateral position(62.3%).Conclusion These findings offer valuable insights for midwifery practice and help inform future research directions.Considering the limitations of this review,more larger-scale,multicenter randomized controlled trials are warranted to further evaluate the relative effectiveness of different childbirth positions in reducing the duration of the second stage of labor.
基金supported by the General Project of the Cultivation Project of the Chinese Hospital Reform and Development Research Institute of Nanjing University(NDYG2022072)。
摘要Objective Systematically integrate nurses’experience with“Internet Nursing Service”to analysis the nurses’experiences with“Internet Nursing Service”,and to provide a theoretical reference for formulating a more rational“Internet Nursing Service”model.Methods A systematic search in PubMed,Embase,Web of Science,the Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and Chinese Biomedical Literature Database was conducted to collect qualitative research on nurses’experiences with“Internet Nursing Service,”with a retrieval time limit from December 2019 to June 2024.Qualitative meta-synthesis was performed through line-by-line coding of relevant quotes,organization of codes into descriptive themes,and development of analytical themes.Results A total of 19 studies were included,one study was rated as Grade A in quality evaluation,and the remaining studies were rated as Grade B.Collectively synthesized into three integrated results:Harvest and growth,Difficulties and challenges,and Expectations and support.Harvest and growth,include 1)manifestation of self-value,2)enhancing nursing capabilities,3)optimizing nursing resources;Difficulties and challenges,include 1)lack of safety guarantee,2)role conflict;Expectations and support include,1)expectation for professional knowledge and skill training,2)expectations for service platform optimization,3)expectation for reasonable charges,4)expectation for related policy support.Conclusion“Internet Nursing Service”model benefits both nurses and patients,but still full of challenges.It aids in the decentralization of medical resources.Management departments still need to encourage nurses to actively invest in“Internet Nursing Service”while ensuring their safety and interests.
基金funded by the Young Clinical Research Special Fund Project of Peking University First Hospital(No.2024YC05)。
摘要Objectives:This study aimed to assess the impact of exercise rehabilitation during the vulnerable period on cardiac recovery(CR)outcomes in patients with acute decompensated heart failure(ADHF).Methods:Multiple databases including PubMed,Web of Science,Embase,the Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Chinese Science and Technology Periodical Database(VIP),Wanfang database,SinoMed,ClinicalTrials.gov,and American Heart Association(AHA)and European Society of Cardiology(ESC)were searched for RCTs on exercise rehabilitation in ADHF patients’vulnerable period from inception to April 2,2025.The risk of bias was assessed with Cochrane Risk of Bias 2.0,and data were analyzed in RevMan 5.3.Results:A total of seven RCTs involving 946 patients were included.The results demonstrated that exercise rehabilitation training during the vulnerable period in patients with ADHF significantly increased the 6-min walk test distance(6-MWTD)(SMD=0.37;95%CI:0.09,0.65;P=0.01),short physical performance battery(SPPB)score(MD=1.26;95%CI:0.82,1.70;P<0.001)and peak oxygen consumption(VO2peak)(SMD=1.43;95%CI:0.53,2.34;P=0.002),improved quality of life(QoL)(SMD=0.85;95%CI:0.07,1.64,P=0.03),reduced depression score(MD=-0.73;95%CI:1.27,-0.18;P=0.009),frailty(MD=-0.22;95%CI:-0.48,0.05;P=0.11),and decreased 6-month all-cause readmission(OR=0.67;95%CI:0.49,0.91;P=0.01).However,no statistically significantdifferences were observed between the two groups in left ventricular ejection fraction(LVEF)(MD=0.96;95%CI:-1.84,3.77;P=0.50),6-month heart failure(HF)-related readmission(OR=1.01;95%CI:0.66,1.53;P=0.98),and all-cause mortality(OR=0.63;95%CI:0.18,2.24;P=0.47).There were no adverse events reported.Conclusions:Exercise rehabilitation during the vulnerable phase improves exercise tolerance,QoL,and depressive symptoms while reducing 6-month all-cause readmissions in ADHF patients,with no reported adverse events.Although trends toward improved LVEF,HF-related readmissions,and all-cause mortality were observed.Large-scale,high-quality studies are warranted to explore individualized responses and long-term outcomes.
摘要Objectives:Workplace violence is a serious issue in healthcare settings.Nurses are particularly vulnerable,and such violence significantly impacts their professional lives,leading to decreased productivity and care quality.We aimed to estimate the pooled prevalence of workplace violence against nurses through systematic review and meta-analysis in Saudi Arabia.Methods:Databases were searched for articles published in English from 2013 to 2023,including PubMed,Web of Science,Science Direct,Medline,Emerald,Wiley,and ProQuest.The quality of the included studies was rigorously assessed using the Joanna Briggs Institute(JBI)critical appraisal tools.Meta-analysis was conducted using Comprehensive Meta-Analysis software.Subgroup analysis,metaregression,and publication bias tests were performed.Results:The pooled prevalence of workplace violence among nurses in Saudi Arabia was 61.8%(95%CI:45.8%-75.6%).Subgroup analysis showed the highest prevalence of workplace violence in studies conducted before 2020 at 69.7%(95%CI:42.0%-88.0%)and 2020-2023 at 57.0%(95%Cl:35.6%-76.1%);in the western region at 90.2%(95%CI:70.2%-97.3%);among female nurses at 81.8%(95%Cl:66.9%-90.9%);with patient relatives as perpetrators at 70.8%(95%Cl:46.4%-87.2%);during afternoon shifts at 78.5%(95%CI:64.4%-88.1%);for verbal abuse at 54.9%(95%Cl:31.3%-76.6%);and in the intensive care unit at 68.1%(95%Cl:28.1%-92.1%).Meta-regression analysis revealed that the night shift significantly contributed to heterogeneity.The funnel plot and Egger's regression test(P=0.647)indicated no significant publication bias.Conclusions:This meta-analysis showed the estimate of workplace violence against nurses in Saudi Arabia is 61.8%.Nursing managers and health policymakers should implement targeted interventions to prevent workplace violence,especially among female nurses,during afternoon shifts,in intensive care units,and in the western region of Saudi Arabia.
基金supported by the Key Research and Development Program of Yunnan Science and Technology Department(Grant No.202303AC100326)the National Natural Science Foundation of China(Grant No.81960863)the Education Department of Yunnan Province(Grant No.2023Y0463 and 2024Y380).
摘要This study aimed to systematically evaluate the clinical efficacy of combining wax therapy with conventional drug therapy for rheumatoid arthritis(RA)and to provide evidence supporting its clinical application.A comprehensive search was conducted across PubMed,Cochrane Library,China Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI),Wanfang,and VIP databases from their inception to May 2024.Randomized controlled trials(RCTs)investigating the combination of wax therapy and conventional drug therapy for RA were included in the analysis.Statistical analysis was performed using Review Manager 5.3 software.Nine studies,encompassing a total of 843 patients,were included.The results demonstrated that the combination therapy significantly improved clinical efficacy compared to conventional drug therapy alone[RR=1.22,95%CI(1.11,1.34)].Moreover,the combination therapy led to notable improvements in DAS 28 scores[MD=-0.90,95%CI(-1.23,-0.57),P<0.00001],VAS scores[MD=-0.90,95%CI(-1.13,-0.66),P<0.00001],reduction in joint tenderness[MD=-1.27,95%CI(-1.81,-0.72),P<0.00001],decreased duration of morning stiffness[MD=-25.47,95%CI(-34.33,-16.61),P<0.00001],and lowered C-reactive protein levels[MD=-6.29,95%CI(-12.02,-0.57),P<0.05].In conclusion,wax therapy combined with conventional anti-rheumatic drugs significantly enhanced the clinical outcomes for RA patients by alleviating symptoms,reducing joint pain and morning stiffness,and decreasing inflammatory markers more effectively than conventional drug therapy alone.
基金supported by Major Scientific Research Special Project for High-level Talents in Health and Wellness,Hunan Province(R2023072)Project of Hunan Provincial Department of Finance(2050205)Hunan Provincial Department of Finance Project(050205).
摘要Objective This systematic review and meta-analysis aimed to identify the main factors influencing the public’s willingness to participate in out-of-hospital emergency care.Methods Studies were searched in online databases,including PubMed,Embase,Web of Science,and the Cochrane Library.The articles included in this review were published from inception to July 31,2024.The Iain Crombie assessment tool was used to assess study quality.Meta-analysis was performed using RevMan(version 5.4)software.The review protocol has been registered with PROSPERO(CRD42024570491).Results A total of 1,434 research articles were initially identified,among which 18 were incorporated into this study,and all of the included studies were cross-sectional.Meta-analysis results demonstrated that gender(male;OR=1.37,95%CI:1.28–1.47),profession(healthcare provider;OR=0.17,95%CI:0.06–0.47),knowledge and skill level(OR=1.63,95%CI:1.25–2.11),willingness to undergo training(OR=2.68,95%CI:1.89–3.79),interest in first aid(OR=2.08,95%CI:1.60–2.69),previous training(OR=2.14,95%CI:1.49–3.08),and previous first-aid experience(OR=1.70,95%CI:1.37–2.11)were the principal influencing factors of the public’s willingness to engage in out-of-hospital cardiopulmonary resuscitation.Conclusion Demographic factors,knowledge,belief,and behavior are crucial in influencing public emergency decision-making.Medical personnel could create specialized training programs based on relevant factors to enhance the public's willingness to engage in out-of-hospital CPR.