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MXene-Assembled Liquid Metal Hybrid Microparticles for Multifunctional and Stretchable Printed Electronics 认领 引用
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作者 Rouhui Yu Jiexin Qiu +8 位作者 Hui Zhu Xiangheng Du Jiale Sun Zishuo Zhang Long Chen Zhongyao Fan Huifang Chen Meifang Zhu Shaowu Pan 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第9期487-503,共17页
Stretchable printed electronic devices are essential for the advancement of soft robotics,bioelectronics,and wearable systems.Liquid metals,owing to their high electrical conductivity and intrinsic deformability,have ... Stretchable printed electronic devices are essential for the advancement of soft robotics,bioelectronics,and wearable systems.Liquid metals,owing to their high electrical conductivity and intrinsic deformability,have emerged as promising candidates for these applications.However,their limited functionality hinders their integration into multifunctional electronic devices.Here,we present versatile MXene-assembled liquid metal hybrid microparticles(MLHMs),which serve not only as conductive platforms for diverse electronic devices but also as electrochemical electrodes for stretchable energy storage devices.This multifunctionality stems from their unique structure,in which MXene nanosheets self-assemble around liquid metal microparticles via coordination interactions,forming an interconnected hybrid network within the printed pattern.This architecture enables the activation of electrical conductivity in hybrid microparticles at a minimal strain of 2.5%,achieving a high electrical conductivity of 3.7×105S m-1and excellent stretchability of~700%.The MLHMs demonstrate multifunctionality in stretchable antennas,micro-supercapacitors,electroluminescent devices,and flexible printed circuit boards,enabling wireless power transmission,energy storage,and stretchable and interactive display.These hybrids represent versatile material units for advancing stretchable and integrated electronic systems. 展开更多
关键词 Liquid metals MXene Hybrid microparticles Multifunctional electronics
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Microparticles at the crossroads of the gut-kidney axis:Mechanistic drivers and therapeutic horizons in hemodialysis 认领 引用
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作者 Thansita Bhunyakarnjanarat Asada Leelahavanichkul Wiwat Chancharoenthana 《World Journal of Nephrology》 2026年第2期140-153,共14页
Chronic kidney disease(CKD)and end-stage kidney disease(ESKD)pose significant global health challenges,with hemodialysis serving as a vital treatment for ESKD patients.Despite its life-sustaining role,hemodialysis is ... Chronic kidney disease(CKD)and end-stage kidney disease(ESKD)pose significant global health challenges,with hemodialysis serving as a vital treatment for ESKD patients.Despite its life-sustaining role,hemodialysis is associated with elevated cardiovascular morbidity and mortality,driven in part by the accumulation of uremic toxins.Recent research underscores the gut-kidney axis as a pivotal contributor to CKD progression and its complications,with gut microbiota dysbiosis amplifying uremic toxin production.Microparticles(MPs)-small extracellular vesicles released from cells-have emerged as key mediators in intercellular communication,inflammation,and vascular dysfunction.This review examines the role of MPs in the gut-kidney axis,with a focus on their contribution to uremic toxicity and clinical outcomes in hemodialysis patients.We explore how MPs,originating from endothelial cells,platelets,and gut microbiota,transport bioactive molecules,intensify inflammation,and impair endothelial function,thereby heightening cardiovascular risk.Furthermore,we assess their potential as biomarkers of disease severity and as novel therapeutic targets.By integrating current evidence,this review elucidates the intricate interplay between MPs,the gut-kidney axis,and uremic toxicity,offering fresh insights into improving outcomes for hemodialysis patients. 展开更多
关键词 Microparticles Gut-kidney axis Hemodialysis Uremic toxins Chronic kidney disease
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Clotrimazole-loaded PLGA microparticles for local drug delivery to the vagina:Shape does matter 认领 引用
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作者 Yanyu Li Jingting Luo +6 位作者 Shitao Zou Xin Zhang Zhen Wang Ziwen Jiang Jingjie Wang Zhaoxia Liu Zhimin Zhou 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第4期752-764,共13页
Background:Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health,such as vulvovaginal candidiasis(VVC).However,conventional vaginal formulations ... Background:Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health,such as vulvovaginal candidiasis(VVC).However,conventional vaginal formulations in the clinic face challenges such as drug leakage and low bioavailability due to the mucus barrier and vaginal self-cleaning behavior.To address these limitations,we designed and optimized clotrimazole-loaded PLGA non-spherical microparticles(CPNMs)for vaginal drug delivery.Methods:CPNMs and clotrimazole-loaded PLGA porous microspheres(CPMs)were prepared by the double emulsion-solvent evaporation method.The physicochemical features and in vitro drug release kinetics were characterized,and the effect of shape on drug delivery were also investigated.After intravaginal administration of CPMs and CPNMs,the pharmacokinetics and biocompatibility in the vagina of mice were studied.Results:Both CPMs and CPNMs exhibited sustained release features in vitro.Initially,there was a rapid release within the first 24 h and the cumulative release of CPMs and CPNMs was 46.55%and 56.89%over 7 days,respectively.Compared to CPMs,CPNMs demonstrated an extended drug release in vivo,maintaining a residence duration of at least 72 h,which was beneficial for clotrimazole delivery at a high concentration in the vagina of mice.Histological evaluation demonstrated the low cytotoxicity and good biocompatibility of CPNMs,with no obvious damage to vaginal epithelial cells.Conclusion:This vaginal drug delivery system offers potential applications for managing VVC,along with other health concerns in women. 展开更多
关键词 clotrimazole pharmacokinetics PLGA microparticles shape effect vaginal drug delivery
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Continuous size-based sorting of microparticles using reconfigurable scanning-optical-trap arrays 认领 引用
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作者 Zeran Li Xiaoxia Chen +6 位作者 Yanan Zhang Xi Zhang Yuchao Li Tianli Wu Xiaohao Xu Baoli Yao Yao Zhang 《Advanced Photonics Nexus》 CSCD 2026年第5期201-210,共10页
The continuous,high-precision sorting of microparticles by size is crucial for biomedical and materials science,yet achieving label-free operation,dynamic reconfigurability,and high throughput simultaneously remains c... The continuous,high-precision sorting of microparticles by size is crucial for biomedical and materials science,yet achieving label-free operation,dynamic reconfigurability,and high throughput simultaneously remains challenging.Here,we demonstrate continuous,size-based sorting using reconfigurable scanning-optical-trap(SOT)arrays.The method employs a dynamic optical potential landscape of orthogonally arranged guiding and sorting tracks,created via high-speed laser scanning.Sorting is governed by a tunable“sorting gap”at track junctions,in which size-dependent optical forces deterministically route a particle onto a sorting track only if its diameter exceeds a gap-specific critical value.Simulations establish a predictive one-to-one particle-size-to-optimal-gap relationship.Experimentally,the system achieves a sorting resolution of 90%,an average accuracy>90%(peak 98%at 1000 Hz)within a 900 to 1100 Hz frequency window,and successfully performs the simultaneous,continuous sorting of a fourcomponent polydisperse mixture.This reconfigurable,flow-free,and label-free method bridges precise optical manipulation with higher-throughput sorting,offering a versatile platform for analyzing complex colloidal and biological samples. 展开更多
关键词 optical tweezers microparticle sorting acousto-optic deflector reconfigurable optical traps size-based separation
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Anhydrous sodium sulfate microparticles for efficient water separation from surfactant-stabilized water-in-oil emulsions 认领 引用
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作者 Yan Zou Yuting Xue +6 位作者 Chenxue Du Wenyang Fu Bin Xia Yu He Liang Ao Xiaoshu Lv Guangming Jiang 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第11期194-199,共6页
Herein,a recrystallization approach was used to produce anhydrous sodium sulfate(ASS)microparticles,which are highly efficient and reusable for separating surfactant-stabilized water from water-in-oil emulsions.The AS... Herein,a recrystallization approach was used to produce anhydrous sodium sulfate(ASS)microparticles,which are highly efficient and reusable for separating surfactant-stabilized water from water-in-oil emulsions.The ASS microparticles exhibit distinct morphologies and crystal structures.Remarkably,0.1 g of ASS170 enables the separation of 10 m L of emulsion(water content:0.1 g)with a high separation efficiency of 98.63%.A stepwise separation mechanism,including demulsification and water immobilization in the crystal lattice of ASS,is proposed.The superhydrophilicity of ASS particles enables tiny water droplets to aggregate and merge into larger droplets on their surfaces.This process facilitates the phase transition from ASS to sodium sulfate decahydrate(SSD),during which water molecules are immobilized in the expanded crystal lattice of ASS.SSD particles can be collected to regenerate ASS,retaining the high performance of the original ASS.This unique renewable feature reduces the cost of utilizing ASS and simultaneously prevents secondary pollution.Further economic evaluation reveals that it only costs 66.51USD/m3to purify emulsion with a water content of 10 g/L,significantly lower than previously reported materials.Coupled with a facile and environmentally friendly preparation strategy,this method shows great application potential for water-in-oil emulsion separation and oil purification. 展开更多
关键词 Water-in-oil emulsion Oil-water separation Sodium sulfate decahydrate Phase transition Microparticles
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Comparative analysis of UPLC-MS/MS and chemiluminescence microparticle immunoassay for serum methotrexate measurement in pediatric intracranial tumor patients 认领 引用 被引量：2
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作者 Zhengyuan Shi Jingfeng Li +2 位作者 Chunjing Yang Xiqiao Xu Dechun Jiang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2025年第5期423-431,共9页
This study aimed to establish a highly accurate method for quantifying methotrexate(MTX)concentrations in serum using an ultra-high performance liquid chromatography-tandem mass spectrometry system(UPLC-MS/MS)and to c... This study aimed to establish a highly accurate method for quantifying methotrexate(MTX)concentrations in serum using an ultra-high performance liquid chromatography-tandem mass spectrometry system(UPLC-MS/MS)and to compare its performance with the chemiluminescence microparticle immunoassay(CMIA).A total of 211 serum samples from pediatric patients with intracranial tumors undergoing high-dose MTX treatment were analyzed using both techniques.Correlation and agreement analyses were performed to assess the level of concordance between these methods.The results demonstrated a significant correlation(P<0.05)between the two methods,with correlation coefficients of 0.9913 and 0.9893,respectively.However,a statistical difference was noted in MTX serum concentrations at lower levels(0.04-1.5μmol/L),while no significant difference was observed at higher concentrations(1.5-400μmol/L).Specifically,in the 0.04-1.5μmol/L range(107 cases),Bland-Altman analysis indicated a bias of 0.018 between the two methods.Given the observed discrepancies,particularly at lower concentrations,it is advised that the UPLC-MS/MS method should not be used interchangeably with the CMIA assay for therapeutic drug monitoring in patients receiving high-dose MTX treatment. 展开更多
关键词 Methotrexate Therapeutic drug monitoring UPLC-MS/MS Chemiluminescence microparticle immunoassay
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Preparation of Thermosensitive Chitosan Formulations Containing 5-Fluorouracil/Poly-3-hydroxybutyrate Microparticles Used as Injectable Drug Delivery System 认领 引用 被引量：7
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作者 昝佳 朱德权 +3 位作者 谭丰苹 蒋国强 林莹 丁富新 《Chinese Journal of Chemical Engineering》 SCIE EI CAS 2006年第2期235-241,共7页
The auto-gelling and drug release properties of the thermosensitive chitosan-β-glycerophosphate formulation were investigated. According to rheological study, gelation lag time of chitosan/β-glycerophosphate （GP） ... The auto-gelling and drug release properties of the thermosensitive chitosan-β-glycerophosphate formulation were investigated. According to rheological study, gelation lag time of chitosan/β-glycerophosphate （GP） solutions varied from 2 to 60min with different deacetylation degree of chitosan, pH, gelation temperature, and the particles in the sol. The gelation properties were also found to influence the release profilles of a hydrophilic drug, 5-fluorouracil （5-FU）. Morphological examination by scanning electron microphotography demonstrated that large ＂pores＂ occurred during the gel-forming process, which created hydrophilic environment and led to the rapid initial release of the drug （85% in f＇LrSt 8h）. Poly-3-hydroxybutyrate （PHB）, a biodegradable material, was applied here as scaffold to capture 5-FU into microparticles with high encapsulation efficiency by solvent-nonsolvent method. Combination of these microparticles into the chitosan-β-GP formulation could drop the rapid initial release from 85% down to 29% in the optimized PHB content （75%, by mass）. The release could sustain for about 10 months. Tiffs study provided an understanding of the potential of injectable implant using thermosensitive chitosan-β-GP formulation containing PHB based particles for the water soluble drugs that need the property of long-term delivery. 展开更多
关键词 hydrogel chitosan injectables microparticle drug release
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High‑Performance Silicon‑Rich Microparticle Anodes for Lithium‑Ion Batteries Enabled by Internal Stress Mitigation 认领 引用 被引量：10
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作者 Yao Gao Lei Fan +3 位作者 Rui Zhou Xiaoqiong Du Zengbao Jiao Biao Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第12期99-114,共16页
Si is a promising anode material for Li ion batteries because of its high specific capacity,abundant reserve,and low cost.However,its rate performance and cycling stability are poor due to the severe particle pulveriz... Si is a promising anode material for Li ion batteries because of its high specific capacity,abundant reserve,and low cost.However,its rate performance and cycling stability are poor due to the severe particle pulverization during the lithiation/delithiation process.The high stress induced by the Li concentration gradient and anisotropic deformation is the main reason for the fracture of Si particles.Here we present a new stress mitigation strategy by uniformly distributing small amounts of Sn and Sb in Si micron-sized particles,which reduces the Li concentration gradient and realizes an isotropic lithiation/delithiation process.The Si8.5Sn0.5Sb microparticles(mean particle size:8.22μm)show over 6000-fold and tenfold improvements in electronic conductivity and Li diffusivity than Si particles,respectively.The discharge capacities of the Si8.5Sn0.5Sb microparticle anode after 100 cycles at 1.0 and 3.0 A g-1are 1.62 and 1.19 Ah g-1,respectively,corresponding to a retention rate of 94.2%and 99.6%,respectively,relative to the capacity of the first cycle after activation.Multicomponent microparticle anodes containing Si,Sn,Sb,Ge and Ag prepared using the same method yields an ultra-low capacity decay rate of 0.02%per cycle for 1000 cycles at 1 A g-1,corroborating the proposed mechanism.The stress regulation mechanism enabled by the industry-compatible fabrication methods opens up enormous opportunities for low-cost and high-energy-density Li-ion batteries. 展开更多
关键词 Silicon anodes Silicon microparticles Lithium-ion batteries Internal stress
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Microparticle Formation and Crystallization Rate of HMX with Supercritical CO_2 Antisolvent Recrystallization 认领 引用 被引量：14
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作者 蔡建国 周展云 邓修 《Chinese Journal of Chemical Engineering》 SCIE EI CAS 2001年第3期258-261,共4页
Microparticle formation and crystallization rate of 1,3,5,7-tetranitro-l,3,5,7-tetraazacyclooctane (HMX) in acetone solution using supercritical carbon dioxide antisolvent (GAS) recrystallization were studied. Scannin... Microparticle formation and crystallization rate of 1,3,5,7-tetranitro-l,3,5,7-tetraazacyclooctane (HMX) in acetone solution using supercritical carbon dioxide antisolvent (GAS) recrystallization were studied. Scanning electronic microscopy, X-ray diffraction and infrared radiation were used to examine particle size, crystallinity and chemical structure. The results show that B-HMX microparticle in different average size (2-9.5um) and with narrow size distribution were obtained by controlling the expansibility, expansion speed, initial concentration and temperature during recrystallization of HMX. The formation of nuclei may be a main cause of consumption of solute when the solution is expanded rapidly enough and the equilibrium concentration is lower, in which almost monodisperse microparticle can be obtained. 展开更多
关键词 supercritical carbon dioxide microparticle recrystallization rate 1 3 5 7-tetranitro-1 3 5 7-tetraazacyclooctane
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Role of microparticles in endothelial dysfunction and arterial hypertension 认领 引用 被引量：16
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作者 Thomas Helbing Christoph Olivier +2 位作者 Christoph Bode Martin Moser Philipp Diehl 《World Journal of Cardiology》 2014年第11期1135-1139,共5页
Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood... Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. 展开更多
关键词 Microparticles Arterial hypertension Endothelial dysfunction Biological vectors Inflammation
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Seasonal and Spatial Variability of Microparticles in Snowpits on the Tibetan Plateau, China 认领 引用 被引量：4
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作者 ZHANG Yulana KANG Shichang +3 位作者 ZHANG Qianggong CONG Zhiyuan ZHANG Yongjun GAO Tanguang 《Journal of Mountain Science》 SCIE 2010年第1期15-25,共11页
The work presents microparticle concentrations in snowpits from the East Rongbuk Glacier on Mt. Qomolangma (Everest) (ER) (28.02°N, 86.96°E, 6536 m a.s.l.), the Zhadang Glacier on Mt. Nyainqentanglha (NQ) (3... The work presents microparticle concentrations in snowpits from the East Rongbuk Glacier on Mt. Qomolangma (Everest) (ER) (28.02°N, 86.96°E, 6536 m a.s.l.), the Zhadang Glacier on Mt. Nyainqentanglha (NQ) (30.47°N, 90.65°E, 5800m a.s.l.), and the Guoqu Glacier on Mt. Geladaindong (GL) (33.95°N, 91.28°E, 5823m a.s.l.) over the Tibetan Plateau (TP). Variations of microparticle and major ions (e.g. Mg2+, Ca2+) concentrations in snowpits show that the values of the microparticles and ions in the non-monsoon seasons are much higher than those in the monsoon seasons. Annual flux of microparticle deposition at ER is lower than those at NQ and GL, which could be attributed to the long distance away from the possible dust source regions as well as the elevation for ER higher than the others. Compared with other remote areas, microparticle concentrations in the southern TP are much lower than those in the northern TP, but still much higher than those in Greenland and Antarctica. The seasonal and spatial microparticle variations are clearly related to the variations of atmospheric circulation according to the air mass 5-day backward trajectory analyses of HYSPLIT Model. Resultingly, the high microparticle values in snow are mainly attributed to the westerlies and the strong dust storm outbreaks on the TP, while the monsoon circulation brings great amount of precipitation from the Indian Ocean, thus reducing in the aerosol concentrations. 展开更多
关键词 Microparticle seasonal change spatialvariation snowpits Tibetan Plateau
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Supercritical Antisolvent Precipitation of Microparticles of Quercetin 认领 引用 被引量：7
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作者 刘学武 李志义 +1 位作者 韩冰 苑塔亮 《Chinese Journal of Chemical Engineering》 SCIE EI CAS 2005年第1期128-130,共3页
Supercritical antisolvent (SAS) process is a recently developed technology to produce micro- and nano particles. This paper presents a continuous apparatus to conduct experiment of SAS process. With the apparatus, the... Supercritical antisolvent (SAS) process is a recently developed technology to produce micro- and nano particles. This paper presents a continuous apparatus to conduct experiment of SAS process. With the apparatus, the effects of pressure, temperature and flow ratio of CO2 to the solution on the shape and size of particles are studied for the quercetin-ethanol-CO2 system. Spherical quercetin microparticles with diameters ranging form 1 μm to 6μm can be obtained while ethanol is used as organic solvent. The most effective fact on the shape and size of particles is pressure, the next is temperature and the last is the flow ratio of CO2 to solution. 展开更多
关键词 supercritical antisolvent process microparticles quercetin
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Thermally stable ultrafine grained copper induced by CrB/CrB2 microparticles with surface nanofeatures via regular casting 认领 引用 被引量：4
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作者 Gongcheng Yao Chezheng Cao +3 位作者 Shuaihang Pan Jie Yuan Igor De Rosa Xiaochun Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2020年第23期55-62,共8页
Ultrafine-grained(UFG)anocrystalline materials possess novel properties. Refining as-solidified grains of metals to the ultrafine and even nanometer scale by nanoparticles via slow cooling has been recently discovered... Ultrafine-grained(UFG)anocrystalline materials possess novel properties. Refining as-solidified grains of metals to the ultrafine and even nanometer scale by nanoparticles via slow cooling has been recently discovered. Here, we report that microparticles(CrB and CrB2) with surface nanofeatures can also enable ultrafineano grains via slow cooling. CrB/CrB2 microparticles, formed by coalescence of nanoparticles in Cu matrix, display surface nanofeatures, which induce substantial grain refinement and stabilization down to the ultrafineano scale. The UFG Cu/Cr B and Cu/CrB2 samples exhibit exceptional thermal stability, comparable to UFG Cu induced by nanoparticles, without coarsening after annealing at 600°C for 1 h. The microhardness, strengths, and Young's moduli of the Cu/Cr B and Cu/CrB2 samples are significantly enhanced over pure Cu. This discovery has great potential to advance the mass production UFGanocrystalline for widespread applications. 展开更多
关键词 Copper Microparticles with nanofeatures Casting Ultrafine grains Thermal stability
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Ionic/electronic conductivity regulation of n-type polyoxadiazole lithium sulfonate conductive polymer binders for high-performance silicon microparticle anodes 认领 引用 被引量：3
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作者 Yuanyuan Yu Huihui Gao +6 位作者 Jiadeng Zhu Dazhe Li Fengxia Wang Chunhui Jiang Tianhaoyue Zhong Shuheng Liang Mengjin Jiang 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期203-209,共7页
Low-cost silicon microparticles(SiMP),as a substitute for nanostructured silicon,easily suffer from cracks and fractured during the electrochemical cycle.A novel n-type conductive polymer binder with excellent electro... Low-cost silicon microparticles(SiMP),as a substitute for nanostructured silicon,easily suffer from cracks and fractured during the electrochemical cycle.A novel n-type conductive polymer binder with excellent electronic and ionic conductivities as well as good adhesion,has been successfully designed and applied for high-performance SiMP anodes in lithium-ion batteries to address this problem.Its unique features are attributed to the stro ng electron-withdrawing oxadiazole ring structure with sulfonate polar groups.The combination of rigid and flexible components in the polymer ensures its good mechanical strength and ductility,which is beneficial to suppress the expansion and contraction of SiMP s during the charge/discharge process.By fine-tuning the monomer ratio,the conjugation and sulfonation degrees of the polymer can be precisely controlled to regulate its ionic and electronic conductivities,which has been systematically analyzed with the help of an electrochemical test method,filling in the gap on the conductivity measurement of the polymer in the doping state.The experimental results indicate that the cell with the developed n-type polymer binder and SiMP(~0.5 μm) anodes achieves much better cycling performance than traditional non-conductive binders.It has been considered that the initial capacity of the SiMP anode is controlled by the synergetic effect of ionic and electronic conductivity of the binder,and the capacity retention mainly depends on its electronic conductivity when the ionic conductivity is sufficient.It is worth noting that the fundamental research of this wo rk is also applicable to other battery systems using conductive polymers in order to achieve high energy density,broadening their practical applications. 展开更多
关键词 n-Doping Conductive binder Electronic conductivity Ionic conductivity High-performance silicon microparticle anodes
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Comparison of chemiluminescence enzyme immunoassay based on magnetic microparticles with traditional colorimetric ELISA for the detection of serumα-fetoprotein 认领 引用 被引量：6
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作者 Qian-Yun Zhang Hui Chen +1 位作者 Zhen Lin Jin-Ming Lin 《Journal of Pharmaceutical Analysis》 CAS 2012年第2期130-135,共6页
A chemiluminescence enzyme immunoassay based on magnetic microparticles(MmPs-CLEIA)was developed to evaluate serum a-fetoprotein(AFP)in parallel with traditional colorimetric enzyme-linked immunosorbent assay(ELISA).A... A chemiluminescence enzyme immunoassay based on magnetic microparticles(MmPs-CLEIA)was developed to evaluate serum a-fetoprotein(AFP)in parallel with traditional colorimetric enzyme-linked immunosorbent assay(ELISA).A systematic comparison between the MmPs-CLEIA and colorimetric ELISA concluded that the MPs-CLEIA exhibited fewer dosages of immunoreagents,less total assay time,and better linearity,recovery,precision,sensitivity and validity.AFP was detected in forty human serum samples by the proposed MPs-CLEIA and ELISA,and the results were compared with commercial electrochemiluminescence immunoassay(ECLIA)kit.The correlation coefficient between MPs-CLEIA and ELISA was obtained with R 20.6703;however,the correlation between MPs-CLEIA and ECLIA(R 20.9582)was obviously better than that between colorimetric ELISA and ECLIA(R 20.6866). 展开更多
关键词 a-Fetoprotein Hepatocellular carcinoma Chemiluminescence enzyme immunoassay Magnetic microparticles Colorimetric enzyme-linked immunosorbent assay
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Preparation and Crystal Modification of Ibuprofen-Loaded Solid Lipid Microparticles 认领 引用 被引量：4
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作者 龙春霞 章莉娟 钱宇 《Chinese Journal of Chemical Engineering》 SCIE EI CAS 2006年第4期518-525,共8页
An emulsion-congealing technique is used to prepare solid lipid microparticles （SLM） containing ibuprofen with glyceryl behenate, tripalmitin and beewax as excipients. The difference of the solubility parameters bet... An emulsion-congealing technique is used to prepare solid lipid microparticles （SLM） containing ibuprofen with glyceryl behenate, tripalmitin and beewax as excipients. The difference of the solubility parameters between the excipients and ibuprofen are used to analyze their compatibility. Both the solubility parameter analysis and the experimental results show that glyceryl behenate is the best among the three excipients. The solid particles disperse well in aqueous phase when the drug loading reaches 10% （relative to lipid only）. Glycerides exhibit marked polymorphism and their rapid rates of crystallization accelerate the formation of metastable crystal modification. The metastable crystal modification characterizes high drug loading capacity but less stability. Increasing the content of lipophilic drug in a lipid matrix facilitates the transformation of excipients to more stable polymorphic forms. 展开更多
关键词 solid lipid microparticles crystal modification solubility parameter drug loading capacity ibuprofen
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Biofabrication of size-controlled liver microtissues incorporated with ECM-derived microparticles to prolong hepatocyte function 认领 引用 被引量：2
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作者 Zahra Heydari Ibrahim Zarkesh +11 位作者 Mohammad-Hossein Ghanian Mahdokht HAghdaei Svetlana Kotova Ensieh Zahmatkesh Zahra Farzaneh Abbas Piryaei Iman Akbarzadeh Anastasia Shpichka Roberto Gramignoli Peter Timashev Hossein Baharvand Massoud Vosough 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2021年第4期790-805,共16页
Multicellular microtissues of primary human hepatocytes(PHHs)co-cultured with other supporting cell types are a promis-ing model for drug screening and toxicological studies.However,these liver microtissues(LMs)rapidl... Multicellular microtissues of primary human hepatocytes(PHHs)co-cultured with other supporting cell types are a promis-ing model for drug screening and toxicological studies.However,these liver microtissues(LMs)rapidly lose their functions during ex vivo culture.Here,in order to mimic the cellular and structural hepatic microenvironment,we co-cultured PHHs with human mesenchymal stromal cells(MSCs)and human umbilical vein endothelial cells(HUVECs)in the presence of cell-sized microparticles(MPs)derived from liver extracellular matrix(LEMPs).The microwell culture platform enabled biofabrication of size-controlled multicellular microtissues(PHH:HUVEC:MSC=3:2:1)with efficient LEMP incorporation(about 70%at a 2:1 ratio of cells:MP).The biofabricated liver microtissues(BLMs)were cultured ex vivo for 14 days and compared to the cell-only LM in terms of gene and protein expression,functional activity,cytochrome P450(CYP450)enzyme inducibility,and drug sensitivity.The results supported superior hepatic-related gene expression,functional activity,and polarity for PHH in BLM compared to LM.CYP450 enzyme inducibility and dose-responsive sensitivity to toxic drugs were significantly higher in the BLM group.In conclusion,microtissue engineering by incorporation of tissue-specific microparticles within a multicellular microtissue can offer some advantages for drug discovery studies and cell transplantation applications.In the near future,this approach could generate a scalable platform of several functional biofabricated microtissues representing different organs. 展开更多
关键词 Liver microtissue Hepatocyte maintenance Microparticles Decellularized tissue Drug screening
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The synergistic role of Ti microparticles and CeO2 nanoparticles in tailoring microstructures and properties of high-quality Ni matrix nanocomposite coating 认领 引用 被引量：2
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作者 Lianbo Wang Shilong Xing +4 位作者 Zizhen Shen Huabing Liu Chuanhai Jiang Vincent Ji Yuantao Zhao 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第10期182-193,共12页
In current work,Ni-Ti-CeO2 nanocomposite coatings were achieved by co-adding Ti microparticles and CeO2 nanoparticles.Designed experiments and COMSOL computer simulation were applied to reveal the synergistic ro... In current work,Ni-Ti-CeO2 nanocomposite coatings were achieved by co-adding Ti microparticles and CeO2 nanoparticles.Designed experiments and COMSOL computer simulation were applied to reveal the synergistic role of Ti microparticles and CeO2 nanoparticles in tailoring the spatial microstructures and properties of Ni-Ti-CeO2 nanocomposite coating.Unilaterally,the conductive Ti microparticles conducted the growth behavior of Ni grains by current density concentration,distorting electronic feld lines and heterogeneous nucleation.Individual domains consisting of inner nanograins and outer radial columnar grains surrounded Ti microparticles,where Ti microparticles acted as seeds.Ti microparticles tended to be aggregated,leading to spatial heterogeneity of microstructures.Ni deposits buried the Ti microparticles in forms of“covering model”,contributing to the formation of inside voids and rough surface and aggregation of Ti microparticles;on the other hand,the non-conductive CeO2microparticles hardly changed the distribution of current density and electronic feld lines on the cathode surface.Ni deposits buried the CeO2microparticle in forms of“stacking model”,avoiding the inside voids and aggregation of particles.The incorporation of CeO2microparticle brought in microstructure evolutions only on its top side without disturbing the growth behavior of Ni grains on its lateral side or bottom,suggesting the limited effects.This was correlated with the presence of current concentration above the CeO2 microparticle at the last stage of burying CeO2 microparticle.The co-addition of Ti microparticles and CeO2 nanoparticles into Ni deposits exploited the complementary action of the two particles,which gave birth to satisfed spatial microstructures and improved hardness.Ti microparticles took major responsibility for microstructure evolutions,while the CeO2 nanoparticles were mainly in charge of the microstructure homogeneity. 展开更多
关键词 Nanocomposite coating CeO2nanoparticle Ti microparticles Grain growth behavior COMSOL computer simulation Spatial microstructure and spatial hardness
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Changes in the frequency of myeloid-derived suppressor cells after transarterial chemoembolization with gelatin sponge microparticles for hepatocellular carcinoma 认领 引用 被引量：3
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作者 Yuanxun Yue Zhizhong Ren +1 位作者 Ying Liu Yuewei Zhang 《Journal of Interventional Medicine》 2019年第1期21-26,共6页
Purpose: A series of clinical studies have established the safety and efficacy of transcatheter arterial chemoembolization(TACE) with gelatin sponge microparticles(GSMs) in treating hepatocellular carcinoma(HCC). HCC ... Purpose: A series of clinical studies have established the safety and efficacy of transcatheter arterial chemoembolization(TACE) with gelatin sponge microparticles(GSMs) in treating hepatocellular carcinoma(HCC). HCC can lead to obvious necrosis inside tumors, especially larger ones, although it is unclear whether such necrotic tumor tissue can induce favorable immune reactions against the tumor. Myeloid-derived suppressor cells(MDSCs)have immunosuppressive functions and are currently considered a very important cell type affecting tumor immunity. This study observed changes in MDSC frequency in peripheral blood before and after GSM–TACE to evaluate the effect on the immune function of HCC patients.Methods: Eight patients diagnosed with HCC underwent GSM–TACE treatment in the Hepatobiliary Interventional Department of Beijing Tsinghua Chang Gung Hospital, Beijing, China;we followed up with the patients over a period of 30 days post-surgery. We used flow cytometry(FCM) to quantify the frequency of MDSCs in peripheral blood before TACE, 10 days after surgery and 30 days after surgery.Results: MDSC frequency after GSM–TACE had a significant downward trend. Pre-TACE, it was 30.73% ? 11.93%,decreasing to 18.60% ? 11.37% at 10 days after operation. This decrease was not statistically significant(P > 0.05). MDSC frequency was even lower 30 days after TACE(7.63% ? 7.32%) than at 10 days after TACE(P < 0.05), and there was a significant difference compared with pre-TACE(P < 0.001). We evaluated tumor response at 30 days after GSM–TACE according to the Modified Response Evaluation Criteria in Solid Tumors(mRECIST), and all eight patients showed partial response(PR).Conclusion: Our results confirmed that GSM–TACE was beneficial for improving anti-tumor immunity in the treatment of HCC. 展开更多
关键词 Gelatin sponge microparticles–transcatheter arterial chemoembolization(GSMs-TACE) Hepatocellular carcinoma Myeloid-derived suppressor cells(MDSCs) Immunology
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Increased levels of circulating platelet-derived microparticles in psoriasis:Possible implications for the associated cardiovascular risk 认领 引用 被引量：2
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作者 Evangelia Papadavid Konstantina Diamanti +8 位作者 Aris Spathis Maria Varoudi Ioanna Andreadou Kostas Gravanis Kostas Theodoropoulos Petros Karakitsos John Lekakis Dimitrios Rigopoulos Ignatios Ikonomidis 《World Journal of Cardiology》 2016年第11期667-675,共9页
AIM To evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODS Forty psoriatic patients without cardiovascu... AIM To evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODS Forty psoriatic patients without cardiovascular disease,and 12 healthy controls were subjected to measurement of baseline platelet CD62 P, CD63 and CD42 b expression, platelet-leukocyte complexes, i.e., platelet-monocyte complexes(PMC), platelet-neutrophil complexes(PNC) and platelet-lymphocyte complexes, and concentrations of platelet-derived microparticles(PMPs) using flow cytometry. Both larger-size(0.5-0.9 μm) and smallersize(< 0.5 μm) PMPs were determined. Serum interleukin(IL)-12 and IL-17 levels were also measured by enzyme-linked immunosorbent assay. The severity of psoriasis was evaluated by the Psoriasis Area Severity Index(PASI).RESULTS PMP concentrations were significantly higher in psoriasis patients than controls [mean±standard error of mean(SEM): 22±5/μL vs 11±6/μL; P=0.018), for both smaller-size(10±2/μL vs 4±2/μL; P=0.033) and larger-size(12±3/μL vs 6±4/μL; P=0.014) PMPs. Platelet CD62 P, CD63 and CD42 b expression and circulating PMC and PNC were similar between the two groups. Lower circulating PLC were observed in psoriasis patients compared to controls(mean±SEM: 16%±3% vs 23%±6%; P=0.047). Larger-size PMPs were related with IL-12 levels(P<0.001) and smaller-size PMPs with both IL-12 and IL-17 levels(P<0.001). Total PMPs also correlated with IL-12(P<0.001). CD63 expression was positively correlated with both IL-12 and IL-17(P<0.05). Increased PASI score was associated with increased levels of larger-size PMPs(r=0.45; P=0.011) and increased CD63 expression(r=0.47; P<0.01).CONCLUSION PMPs, known to be predictive of cardiovascular outcomes, are increased in psoriasis patients, and associated with high inflammatory disease burden. Enhanced platelet activation may be the missing link leading to cardiovascular events in psoriatic patients. 展开更多
关键词 Psoriasis Atherosclerosis Inflammation Platelet activation Platelet-derived microparticles
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