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Prevalence,incidence and modifiable factors for subtypes of mild cognitive impairment:results from the Longitudinal Ageing Study in China 认领 引用 被引量：5
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作者 Tao Wang Haining He +20 位作者 Yanchen Shi Ning Su Minjie Zhu Feng Yan Yuanyuan Liu Juan Li Muni Tang Wei Chen Feng Bao Huali Wang Yuping Wang Ying Liu Yefeng Yuan Xiaoyun Zuo Xulai Zhang Lijuan Cui Wenyuan Wu Chencheng Zhang Yong Lu Yiru Fang Shifu Xiao 《General Psychiatry》 CAS CSCD 2025年第2期93-102,共10页
Background As the population in China rapidly ages,the prevalence of mild cognitive impairment(MCI)is increasing considerably.However,the causes of MCI vary.The continued lack of understanding of the various subtypes ... Background As the population in China rapidly ages,the prevalence of mild cognitive impairment(MCI)is increasing considerably.However,the causes of MCI vary.The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.Aims To estimate the prevalence and incidence rates of two MCI subtypes—amnestic MCI(aMCI)and vascular cognitive impairment without dementia(VCIND)—and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.Method This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large,community-dwelling cohort in China.Baseline lifestyle data were self-reported,while vascular and comorbid conditions were obtained from medical records and physical examinations.In total,3514 and 2051 individuals completed the baseline and 1-year follow-up assessments,respectively.Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline,respectively.Results Among our participants,aMCI and VCIND demonstrated prevalence of 14.83%and 2.71%,respectively,and annual incidence(per 1000 person-years)of 69.6 and 10.6,respectively.The risk factor for aMCI was age,whereas its protective factors were high education level,tea consumption and physical activity.Moreover,VCIND risk factors were age,hypertension and depression.The presence of endocrine disease,cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.Conclusions MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented.Preventive strategies that promote brain activity and support healthy lifestyle choices are required.We identified modifiable factors for MCI in older individuals.The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI. 展开更多
关键词 prevalence vascular cognitive impairment dementia vascular cognitive impairment mild cognitive impairment mci modifiable factors mild cognitive impairment amnestic mild cognitive impairment incidence
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Common Modifiable and Non-Modifiable Risk Factors of Cardiovascular Disease (CVD) among Pacific Countries 认领 引用
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作者 Masoud Mohammadnezhad Tamara Mangum +2 位作者 William May Joshua Jeffrey Lucas Stanley Ailson 《World Journal of Cardiovascular Surgery》 2016年第11期153-170,共18页
Introduction: Modifiable and non-modifiable risk factors contribute to the significant rise of non-communicable diseases (NCDs), most notably cardiovascular disease (CVD), in the Pacific Island nations. The aim of thi... Introduction: Modifiable and non-modifiable risk factors contribute to the significant rise of non-communicable diseases (NCDs), most notably cardiovascular disease (CVD), in the Pacific Island nations. The aim of this study is to review previously published articles to understand common modifiable and non-modifiable risk factors of CVD among Pacific countries. Methods: This systematic review is conducted using different databases including;Scopus, Medline, EMBASE, and psycINFO. This systematic review is based on the Cochrane review process. All articles published in the English language from 1st January 2000 to 1st September 2016, will be included in the study. After reviewing all of the articles’ titles, abstracts, and full text, the final articles were reviewed and the relevant data was included in the data extraction sheet. A descriptive analysis was conducted to measure the common risk factors of CVD in Pacific countries. Results: Overall, 45 articles met the inclusion criteria of the study. The results showed that age was the most common non-modifiable risk factor while diabetes, high blood lipid, and high blood pressure were the most common modifiable risk factors of CVD. There were only three interventional studies which had all of the significant influences in reducing the risk factors of CVD when the results were compared with the control group. Conclusion: While it is not possible to change the non-modifiable risk factors for CVD, we encourage policy makers to use the results of this study to develop health promotion strategies to address the modifiable risk factors for CVD. Interventional strategies are highly recommended in the Pacific countries to tackle the modifiable risk factors for CVD. 展开更多
关键词 Cardiovascular Disease Modifiable Risk Factors Non-Modifiable Risk Factors Pacific
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Modifiable Behavioral Risk Factors Associated with Biological Risk Factors in Subjects at Risk of Type 2 Diabetes in Benin: PREDIBE Study 认领 引用 被引量：1
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作者 Clemence Germaine Metonnou Colette Sylvie Azandjeme +4 位作者 Bio Nigan Issiako Charles Jerome Sossa Ghislain Emmanuel Sopoh Moussiliou Noël Paraïso Victoire Agueh 《Open Journal of Epidemiology》 2020年第4期432-445,共14页
Introduction: Type 2 diabetes is a major public health problem worldwide. This study aimed at identifying modifiable behavioral risk factors associated with biological factors in people at risk of type 2 diabetes whic... Introduction: Type 2 diabetes is a major public health problem worldwide. This study aimed at identifying modifiable behavioral risk factors associated with biological factors in people at risk of type 2 diabetes which could be targeted in the design and implementation of appropriate interventions to prevent the disease. Methods: 180 subjects at risk of type 2 diabetes (aged 15 - 60 years) were identified and selected at random during a preliminary survey conducted in two groups of villages in northeastern Benin. The study took part on August 2017. Questionnaires were administered to consenting subjects;anthropometric measurements taken and blood samples withdrawn. Blood samples were subjected to biochemical testing according to standard protocols. Results: Data was obtained from 180 subjects at risk of type 2 diabetes. The average age of the subjects was 42.76 ± 11.30 years. Multivariate analysis showed inadequate dietary intake score, low physical activity and tobacco use as behavioral factors significantly associated with high waist circumference, high blood sugar, low HDL cholesterol, high triglyceride levels and high body fat percentage. Conclusion: There is a possible association between biological and behavioral risk factors. 展开更多
关键词 Modifiable Risk Factors Type 2 Diabetes Benin
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MODIFIABLE QUARTIC AND QUINTIC CURVES WITH SHAPE-PARAMETERS 认领 引用 被引量：4
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作者 邬弘毅 朱功勤 《Numerical Mathematics A Journal of Chinese Universities(English Series)》 2001年第1期9-19,共11页
This paper presents a method for creating modificable quartic and quintic curves with shape parameters. The curves can achieve C 2 even C 3 continuity and unify both interpolation and approximation to the control poin... This paper presents a method for creating modificable quartic and quintic curves with shape parameters. The curves can achieve C 2 even C 3 continuity and unify both interpolation and approximation to the control points without solving a system of equations or inserting additional control points. They have the local properties like the cubic B spline. Besides, the quintic curve would be able globally to tend the control polygon. 展开更多
关键词 modifiable quartic and quintic curves shape parameters C 2 or C 3 continuity interpolation and approximation.
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Global,regional,and national burden of hepatocellular carcinoma and contribution of nine modifiable risk factors across 185 countries/territories in 2022 认领 引用 被引量：6
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作者 Ping Li Zhan Ding +16 位作者 Yuqi Feng Xiangyu Ren Yongyue Wei Changfa Xia Yitao Yang Quanbo Yang Zhe Wang Xuehong Zhang L.G.van der Geest Herbert Yu Edward Giovannucci David P.Smith Michael David Ahmedin Jemal Xue Qin Yu Hongmei Zeng Guangwen Cao 《Science Bulletin》 SCIE EI CAS CSCD 2026年第4期838-849,共12页
Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer.However,no previous studies systematically provided global HCC burden and population attributable fractions(PAFs)of major risk factors for H... Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer.However,no previous studies systematically provided global HCC burden and population attributable fractions(PAFs)of major risk factors for HCC at the global,regional,subregional,and national levels.We conducted a population-based study to assess the global burden of HCC and the contribution of nine modifiable risk factors.We used data from GLOBOCAN 2022,CI5,GBD 2021,and other large-scale data sources.We categorized nine major modifiable risk factors as infections(hepatitis B or C virus[HBV,HCV],or C.sinensis),metabolic factors(obesity,type 2 diabetes mellitus,and metabolic dysfunction-associated steatotic liver disease[MASLD]),and behavioraloxic factors(high alcohol use,smoking,and aflatoxin B1).In 2022,globally,there were 684,659 new HCC cases and 597,434 deaths,with the highest age-standardized rates observed in Eastern Asia and Northern Africa.An estimated 78.4%(536,571/684,659)of global HCC cases were attributable to the evaluated risk factors,with 82.5%in Asia and 60.4%in America.Infections contributed most worldwide(65.9%),followed by behavioraloxic risk factors(22.4%)and metabolic factors(19.7%).Region-specific predominant risk factors included HBV in Eastern Asia(72.5%),HCV in Northern Africa(43.9%),smoking in Northern America(24.5%),and high alcohol use in Western Europe(24.9%).Between 1990 and 2022,infection and behavioraloxic factors declined globally,whereas metabolic factors steadily increased.The substantial variations in HCC burden and PAF across regions highlight the importance of tailored,region-specific preventive interventions to address the varying modifiable risk factors. 展开更多
关键词 Hepatocellular carcinoma Population attributable fraction Modifiable risk factors Disease burden Trend Prevention
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Menopause status and modifiable risk factors for early menopause in China:a nationwide cross-sectional study on geographical disparities 认领 引用
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作者 Ting Guo Xinyi Wu +18 位作者 Peihao Liu Zifeng Cao Keyan Xu Li Yang Guangmei Huang Qianqian Ma Xiaomin Yang Xin Gao Yehuan Yang Yilin Yang Yajuan Yang XueJiao Shidou Zhao Daimin Wei Junhao Yan Dongshan Zhu Ruimin Zheng Yingying Qin Zi-Jiang Chen 《Science Bulletin》 SCIE EI CAS CSCD 2026年第10期2433-2437,共5页
Menopause,a pivotal biological event marking the irreversible cessation of female reproductive capacity,is intrinsically linked to the aging process[1,2].As global lifespans extend,the societal and individual burden o... Menopause,a pivotal biological event marking the irreversible cessation of female reproductive capacity,is intrinsically linked to the aging process[1,2].As global lifespans extend,the societal and individual burden of age-related diseases is escalating[3].This burden is particularly pronounced among women experiencing premature menopause(before age 40)or early menopause(EM,between ages 40-45),highlighting the critical imperative to understand the multifaceted determinants of age at natural menopause(ANM)[4,5]. 展开更多
关键词 early menopause modifiable risk factors menopause China understand multifaceted determinants aging process geographical disparities
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Modifiable factors for irritable bowel syndrome:evidence from Mendelian randomisation approach 认领 引用 被引量：2
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作者 Di Liu Meiling Cao +7 位作者 Shanshan Wu Yiwen Jiang Weijie Cao Tengfei Lin Fuxiao Li Feng Sha Zhirong Yang Jinling Tang 《eGastroenterology》 2025年第1期83-95,共13页
Background The potential modifiable factors influencing irritable bowel syndrome(IBS)have not been thoroughly documented.We aimed to systematically investigate the modifiable factors associated with IBS,while accounti... Background The potential modifiable factors influencing irritable bowel syndrome(IBS)have not been thoroughly documented.We aimed to systematically investigate the modifiable factors associated with IBS,while accounting for the impact of unobserved confounders and coexisting disorders.Methods Genetic correlation and Mendelian randomisation(MR)analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS.Subsequently,multiresponse MR(MR2)was employed to further examine these associations.Summary-level genome-wide association data were used.Modifiable factors and coexisting disorders(ie,gastrointestinal and psychiatric disorders)were identified based on evidence from cohort studies and meta-analysis.In all analyses,IBS was the primary outcome,while in the MR2 analysis,coexisting disorders were also treated as outcomes alongside IBS.Results Most identified modifiable factors and coexisting disorders exhibited genetic correlations with IBS.MR analyses revealed strong causation between IBS and multisite chronic pain(OR=2.20,95%CI 1.82 to 2.66),gastro-oesophageal reflux disease(OR=1.31,95%CI 1.23 to 1.39),well-being spectrum(OR=0.17,95%CI 0.13 to 0.21),life satisfaction(OR=0.31,95%CI 0.25 to 0.38),positive affect(OR=0.30,95%CI 0.24 to 0.37),neuroticism score(OR=1.20,95%CI 1.16 to 1.25)and depression(OR=1.50,95%CI 1.37 to 1.66).Additionally,smoking,alcohol frequency,college or university degree,intelligence,childhood maltreatment,frailty index,diverticular disease of the intestine and schizophrenia were suggestively associated with IBS.Robust associations were found between multisite chronic pain and both IBS and coexisting disorders.Conclusions Our study identified a comprehensive array of potential modifiable factors and coexisting disorders associated with IBS,supported by genetic evidence,including genetic correlation and multiple MR analyses.The presence of multisite chronic pain may offer a promising avenue for the concurrent prevention of IBS and its coexisting disorders. 展开更多
关键词 Modifiable Factors Irritable Bowel Syndrome Genetic Correlation Mendelian Randomization modifiable factors genetic correlation Coexisting Disorders irritable bowel syndrome ibs
Evaluating the impact of the Modifiable Areal Unit Problem on ecological model inference:A case study of COVID-19 data in Queensland,Australia 认领 引用
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作者 Shovanur Haque Aiden Price +1 位作者 Kerrie Mengersen Wenbiao Hu 《Infectious Disease Modelling》 CSCD 2025年第3期1002-1019,共18页
Accurate identification of spatial patterns and risk factors of disease occurrence is crucial for public health interventions.However,the Modifiable Areal Unit Problem(MAUP)poses challenges in disease modelling by imp... Accurate identification of spatial patterns and risk factors of disease occurrence is crucial for public health interventions.However,the Modifiable Areal Unit Problem(MAUP)poses challenges in disease modelling by impacting the reliability of statistical inferences drawn from spatially aggregated data.This study examines the effect of MAUP on ecological model inference using locally and overseas-acquired COVID-19 case data from 2020 to 2023 in Queensland,Australia.Bayesian spatial Besag-York-Mollié(BYM)models were applied across four Statistical Area(SA)levels,as defined by the Australian Statistical Geography Standard,with and without covariates:Socio-Economic Indexes for Areas(SEIFA)and overseas-acquired(OA)COVID-19 cases.OA COVID-19 cases were also considered a response variable in our study.Results indicated that finer spatial scales(SA1 and SA2)captured localized patterns and significant spatial autocorrelation,while coarser levels(SA3 and SA4)smoothed spatial variability,masking potential outbreak clusters.Incorporating SEIFA as a covariate in locally-acquired(LA)cases reduced spatial autocorrelation in residuals,effectively capturing socioeconomic disparities.Conversely,OA cases showed limited effectiveness in reducing autocorrelation at finer scales.For LA cases,higher socioeconomic disadvantage was associated with increased COVID-19 incidence at finer scales,but this association became non-significant at coarser scales.OA cases showed significant positive association with higher SEIFA scores at finer scales.Model parameters displayed narrower credible intervals at finer scales,indicating greater precision,while coarser levels had increased uncertainty.SA2 emerged as an arguably optimal scale,striking a balance between spatial resolution,model stability,and interpretability.To improve inference on COVID-19 incidence,it is recommended to use data from both SA1 and SA2 levels to leverage their respective strengths.The findings emphasize the importance of selecting appropriate spatial scales and covariates or evaluating the inferential impacts of multiple scales,to address MAUP to facilitate more reliable spatial analysis.The study advocates exploring intermediate aggregation levels and multi-scale approaches to better capture nuanced disease dynamics and extend these analyses across Australia and replicating in other countries with low population densities to enhance generalizability. 展开更多
关键词 Modifiable Areal Unit Problem(MAUP) Bayesian models Spatial patterns Model inference COVID-19 Socio-Economic Indexes for Areas(SEIFA)
Vitamin D defi ciency and fatigue in children:an overlooked Vitamin D deficiency and fatigue in children:an overlooked but modifiable factor? 认领 引用
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作者 Chandra Sekhar Devulapalli 《World Journal of Pediatrics》 SCIE CSCD 2025年第12期1179-1183,共5页
Children often present to pediatric and primary care settings with nonspecific complaints,such as persistent tiredness,low energy,or general malaise.These symptoms are commonly attributed to psychological stressors,ir... Children often present to pediatric and primary care settings with nonspecific complaints,such as persistent tiredness,low energy,or general malaise.These symptoms are commonly attributed to psychological stressors,irregular sleep patterns,or behavioral concerns.However,an emerging body of literature suggests that nutritional factors—particularly vitamin D insufficiency—may represent an underrecognized but reversible cause of fatigue in this group.Vitamin D deficiency is prevalent worldwide,especially among children with limited sun exposure or dietary intake.Despite being largely preventable,hypovitaminosis D often goes unrecognized,especially in children living in high-latitude regions or those whose sun exposure is restricted by lifestyle,clothing,or skin pigmentation.In children with unexplained fatigue,clinicians may miss an opportunity to diagnose and address vitamin D deficiency,thereby improving quality of life through simple intervention. 展开更多
关键词 nutritional factors particularly nutritional factors vitamin d children modifiable factor fatigue d deficiency vitamin D deficiency
Relationship between preoperative modified frailty index,immune inflammation index,and outcomes of colorectal cancer surgery in older patients 认领 引用 被引量：2
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作者 Xing-Si Qi Nai-Ling Liu +1 位作者 Lin Yang Jing Xie 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期151-162,共12页
BACKGROUND With the aging of the population,the proportion of older patients with colorectal cancer(CRC)is increasing annually.Preoperative frailty and chronic inflammatory responses may increase the risk of postopera... BACKGROUND With the aging of the population,the proportion of older patients with colorectal cancer(CRC)is increasing annually.Preoperative frailty and chronic inflammatory responses may increase the risk of postoperative complications and affect long-term survival.AIM To assess modified frailty index(mFI)and systemic immune-inflammation index(SII)for predicting postoperative prognosis in older patients with CRC.METHODS We retrospectively analyzed 247 older patients with CRC who underwent radical resection.The SII was calculated as platelet count×neutrophil count/lymphocyte count.Patients were grouped by complication occurrence.Univariate and multivariate analyses were performed for mFI,SII,and postoperative complications.Using receiver operating characteristic curve analysis,the critical SII value for predicting postoperative recurrence was identified,which was then used to divide patients into high/low mFI and high/low SII groups.Using Kaplan-Meier method between-group survival curves were drawn.RESULTS The 30-day complication rate was 12.55%.Multivariate logistic regression analysis identified smoking history[odds ratio(OR)=4.822],prolonged operation time(OR=1.037),and elevated preoperative mFI(OR=9.342)and SII(OR=1.002)as independent risk factors for postoperative complications(P<0.05).On survival analysis,the average recurrence-free survival(RFS)for patients with a low mFI was 47.04 months[95%confidence interval(CI):45.30-48.79],significantly better than the 33.83 months(95%CI:31.31-36.36)for patients with a high mFI(log-rank,P<0.001).The average RFS for patients with a low SII was 47.00 months(95%CI:45.07-48.94),significantly better than the 40.06 months(95%CI:31.37-43.74)for those with a high SII(log-rank,P<0.001).CONCLUSION In older patients with CRC,the preoperative mFI and SII were significantly correlated with postoperative complications and RFS,warranting closer attention to early recurrence detection and intervention. 展开更多
关键词 Colorectal cancer Laparoscopic radical resection Postoperative complications Recurrence-free survival Modified frailty index Systemic immune-inflammation index
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The modifiable areal unit problem in traffic safety:Basic issue, potential solutions and future research 认领 引用 被引量：2
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作者 Pengpeng Xu Helai Huang Ni Dong 《Journal of Traffic and Transportation Engineering(English Edition)》 2018年第1期73-82,共10页
This study fully addressed the modifiable areal unit problem （MAUP） that was well-known in geography but generally ignored by safety analysis. The basic issue of MAUP was introduced firstly with a case study to expl... This study fully addressed the modifiable areal unit problem （MAUP） that was well-known in geography but generally ignored by safety analysis. The basic issue of MAUP was introduced firstly with a case study to explicitly demonstrate the existence of the problem in macro level crash modeling, and then four potential strategies, i.e., using disaggregate data as possible, capturing spatial non-stationarity, designing optimal zoning systems, conducting sensitivity analysis to report the scope and magnitude of MAUP, were proposed and illustrated in an integrated way, followed by the future research directions. Results revealed that more efforts are desired to calibrate the state-of-art modeling technique at various levels of aggregation based on spatial homogeneity in traffic safety, transport characteristics, and demographical factors. The awareness of this problem in traffic safety domain is expected to the delineation of basic spatial units （e.g. the traffic safety analysis zones）, as well as to provide new insights into the nature of MAUP in statistics and geography. 展开更多
关键词 Modifiable areal unit problem Traffic safety Macro level crash Prediction model Traffic safety analysis zones Review
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Potential application of hydrophobically modified Welan gum as a novel thermo-salt tolerant EOR agent in high-temperature and high-salinity reservoirs 认领 引用
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作者 Jia Chen Zhao-Kai Wang +2 位作者 Wan-Lei Geng Hao-Ran Cheng Guang Zhao 《Petroleum Science》 SCIE EI CAS CSCD 2026年第5期2821-2832,共12页
Conventionalpolymeric systems face significant challengesin maintaining performance under hightemperature,high-salinity reservoir conditions due to limited thermal and saline stability.To address this critical limitat... Conventionalpolymeric systems face significant challengesin maintaining performance under hightemperature,high-salinity reservoir conditions due to limited thermal and saline stability.To address this critical limitation,a hydrophobically modified biopolymer(HWLG)was synthesized via etherification of Welan gum(WLG)with 1-bromooctadecane,introducing alkyl grafts to create hydrophobic microdomains.Comprehensivestructural characterization was performed using Fourier transform infrared spectroscopy(FT-IR),nuclear magnetic resonance spectroscopy(NMR),gel permeation chromatography(GPC),thermogravimetryanalysis(TGA),and scanning electron microscopy(SEM),confirmingsuccessful alkylincorporation.Rheological evaluations demonstrated HWLG's concentrationdependent pseudoplasticity,achieving a viscosity of 1423.2 mPa·s at4000 mg.L-1,which was about 3.4 times that of WLG at 70°C.The HWLG solution showed superior temperature and salt resistance in comparison with unmodified WLG,due to hydrophobic association-driven network formation.Particularly in formation water,HWLG showed a better long-term thermal stability,retaining 64.5%viscosity after aging50 d at 70°C,compared to WLG's 39.6%retention.Core flooding experiments validated HWLG's EOR efficacy,delivering 22.6%incremental oil recovery versus WLG's 13.7%,driven by enhanced mobility control.Theintegration of hydrophobic functionality endows HWLG with exceptional thermosaline stability,adsorption capacity,and viscoelasticity,positioning it as a robust candidate for hightemperature,high-salinity reservoir flooding applications. 展开更多
关键词 Hydrophobically modified biopolymer Welan gum Hydrophobic association Temperature and salt resistance Enhanced oil recovery
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Competitive mechanism of microplastic addition for the adsorption of arsenic from an aqueous solution by magnetic biochar-supported layered double hydroxide 认领 引用
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作者 Zihan Wang Peng Lyu +4 位作者 Lianfang Li Jinli Huang Jing Ye Feng Li Xue Zhou 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第3期832-846,共15页
This study explores the competitive mechanisms of different types of microplastics(MPs)on pentavalent arsenic(As(Ⅴ))adsorption by magnetic biochar-supported layered double hydroxide composite(MBC@LDH).The effects of ... This study explores the competitive mechanisms of different types of microplastics(MPs)on pentavalent arsenic(As(Ⅴ))adsorption by magnetic biochar-supported layered double hydroxide composite(MBC@LDH).The effects of the solution pH,ionic strength,temperature,material dosage,and MP concentration on As(Ⅴ)adsorption were investigated in co-existing MPs and MBC@LDH systems.Results revealed MPs competitively occupied As(Ⅴ)adsorption sites on MBC@LDH,with varying inhibition efficiencies:polyvinyl chloride(PVC)provided 45.44%of the competitive adsorption,representing a significant reduction in adsorption affinity especially in acidic environments and higher ionic strength.The reduced percentage of adsorption capacity of MBC@LDH for As(Ⅴ)induced by polystyrene(PS)was 35.55%,and that for polyethylene(PE)was also just between PVC and PS,especially in acidic environments and higher ionic strength.Further exploration manifested that the presence of MPs decreased the crystallinity of the CaMgAl LDH in MBC@LDH,which disrupted the surface complexation and hydrogen bonding between MBC-LDH and As.In addition,the strengths of the As–O bonds in MBC@LDH were more significantly reduced by PVC with its entering into the binary system rather than PS and PE,which was ascribable to the strong negative charge and hydrophobic separation properties of PVC.Interestingly,PVC promoted the conversion of As(Ⅴ)to As(Ⅲ)on MBC@LDH but not when PE and PS were added,which might be related to the surface chemical bonding and polarity of the different MPs.This study provides a theoretical reference for MPs'competitive adsorption mechanisms of As on porous materials in aqueous environments. 展开更多
关键词 Modified biochar Microplastics Arsenic Competitive adsorption Interaction mechanism
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Characterization of inflammatory pseudotumors in a large animal model of liver cancer 认领 引用
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作者 Erik N.K.Cressman Samantha Hicks +2 位作者 Natalie W.Fowlkes Danielle L.Stolley Maria Sophia Stenkamp 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第2期344-353,共10页
Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this com... Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal. 展开更多
关键词 animals genetically modified disease models animal solid tumors swine
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Fe/Mn-modified biochar immobilizing Pseudomonas hunanensis SK-4 enhanced simultaneous nitrogen and copper removal:Mechanism and application 认领 引用
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作者 Yuhong Zhang Jiacheng Cai +2 位作者 Jiabao Wang Yueqing Jiang Fengyu Che 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期382-390,共9页
To address the challenges posed by the complex composition and high treatment difficulty of composite pollutants,especially copper and nitrogen compounds in water.This study investigated the application of Pseudomonas... To address the challenges posed by the complex composition and high treatment difficulty of composite pollutants,especially copper and nitrogen compounds in water.This study investigated the application of Pseudomonas hunanensis SK-4,which exhibited exceptional resistance to high concentrations of Cu(Ⅱ).Under 100 mg/L Cu(Ⅱ)stress,SK-4 maintained high removal efficiencies of 98.59% for NH4+-N and 83.07%for NO3--N.A novel biocharmicrobial composite(FMABC@SK-4)was prepared by immobilizing SK-4 onto self-synthesized iron-manganese modified biochar.In practical tests,FMABC@SK-4 exhibited excellent simultaneous removal of nitrogen and copper,achieving maximum efficiencies of 99.6% for NH4+-N and 99.43% for Cu(Ⅱ).The results indicated that FMABC@SK-4 removes Cu2+mainly through physical adsorption and surface complexation,whereas nitrogen removal is driven by heterotrophic nitrification-aerobic denitrification and ammonia assimilation processes.These findings underscored the potential of FMABC@SK-4 for treating complex wastewater containing both heavy metals and nitrogen,providing an efficient and mechanism-based strategy for enhanced pollutant removal. 展开更多
关键词 Water treatment Heavy metals Modified biochar Biodegradation Composite pollutants
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A dual-component strategy for ambiently-cured high-toughness red mud based geopolymer:Modified nano-TiO2 and sodium polyacrylate 认领 引用
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作者 CHEN Jing BAI Bing +2 位作者 NIE Qing-ke BAI Fan ZHANG Hai-qing 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第4期1553-1567,共15页
In response to the growing demand for sustainable construction materials,this study overcomes the inherent brittleness and poor fracture resistance of red mud-based geopolymer(RBG)through the strategic combination of ... In response to the growing demand for sustainable construction materials,this study overcomes the inherent brittleness and poor fracture resistance of red mud-based geopolymer(RBG)through the strategic combination of surface-modified nano-TiO 2(NT)and sodium polyacrylate(SPA).The NT was functionalized with silane coupling agent to improve dispersibility and interfacial bonding,while SPA was added to enhance fracture toughness.Under the condition of ambient curing,the optimum mixture containing 3 wt%(glycidoxypropyltriethoxysilane)-modified NT(GNT)and 0.5 wt%SPA achieved a 28 d compressive strength of 43.40 MPa and a flexural strength of 8.16 MPa.The performance index meets the Portland cement(PC 42.5)standards.Microstructural analyses(XRD,FT-IR and SEM EDS)revealed that the formation of geopolymer gel was increased,the crystallinity was reduced,and the degree of polymerization was improved,which confirmed the effectiveness of this method in producing high-toughness and environmentally friendly geopolymer. 展开更多
关键词 red mud geopolymer modified nano-TiO2 sodium polyacrylate synergistic toughening
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Analytical model for lateral peak soil resistance based on pipe-soil interaction full-scale test and numerical simulation 认领 引用
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作者 Xiao-Ben Liu Tian-Wei Kong +4 位作者 Peng-Chao Chen Dong Zhang Wei Huang Lei Li Rui Guo 《Petroleum Science》 SCIE EI CAS CSCD 2026年第5期2846-2862,共17页
Pipelines,as critical infrastructure for oiland gas transportation,require precise evaluation of peak loads in displacement-prone zones to ensure operational safety.The current design guidelines for lateral peak soil ... Pipelines,as critical infrastructure for oiland gas transportation,require precise evaluation of peak loads in displacement-prone zones to ensure operational safety.The current design guidelines for lateral peak soil resistance(ALA-2oO1 and PRCI-2oo9)are based on earlyanalytical studies with limited simulations and physical test data.These guidelines fail to adequately account for the coupled effects of soil friction and cohesion while also overlooking asymmetric soil constraints.These limitations raise significant concerns regarding their applicability in practical engineering scenarios,necessitatingthe development of more accurate analytical methods.The present study combines full-scale lateral pipesoil interaction tests with finite element modeling via the coupled Eulerian-Lagrangian approach in ABAQUS/Explicit.After validation,parametric studies were conducted toestablish a comprehensive database of lateral peak soil resistances.Based on the observed resistance development patterns,the lateral peak resistance calculation equation in ALA-2001 was modified to provide a more accurate analytical model capable of better reflecting real-world pipe-soil interaction behavior.The reliability of the proposed model was confirmed through independentphysical tests,demonstrating its significant value for pipeline engineering design and safety assessment. 展开更多
关键词 Pipe-soil interaction Model tests Finite element simulation Lateral peak soil resistance Modified
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Effects of minimally coupled modified gravity on the gravitational collapse of compact matter structures 认领 引用
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作者 M Yousaf A Rehman +2 位作者 M M M Nasir S Hanif H Asad 《Communications in Theoretical Physics》 SCIE CAS CSCD 2026年第2期134-162,共29页
Our analysis is particularly motivated by its relevance to understanding compact object instabilities,gravitational collapse thresholds,and the formation of dense structures under the influence of modified gravity the... Our analysis is particularly motivated by its relevance to understanding compact object instabilities,gravitational collapse thresholds,and the formation of dense structures under the influence of modified gravity theories.The interplay of anisotropic pressures,perturbative dynamics,and modified gravity contributions offers insight into both the stable configuration of dense fluids and the mechanisms leading to dynamical instability.Such considerations directly contribute to the aims of high energy density profiles,particularly in modeling physical systems where extreme pressure,curvature,and matter interactions co-exist.We consider an axially symmetric,dense structure with anisotropic matter content and employ a specific equation of state(EoS)to examine the interplay between static and dynamic quantities via the adiabatic index.To address the complex dynamics of the collapse process,a perturbative scheme is utilized under Newtonian and post-Newtonian approximations,enabling a detailed examination of the stability and structural evolution of the system under the influence of the considered minimally coupled gravity.Our results demonstrate that hydrostatic equilibrium is maintained when effective pressure,gravitational,and anti-gravitational forces are balanced,while deviations from this balance initiate dynamical instability.Graphical representations of stable and unstable regimes are presented,revealing how the choice of gravity functions significantly affects the outcome.This work provides insight into the behavior of dense,self-gravitating configurations under modified gravity,offering broader implications for the modeling of compact astrophysical objects and contributing to the understanding of gravitational collapse in energy density regimes. 展开更多
关键词 modified theory gravitational collapse dynamical behavior Newtonian post-Newtonian
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Therapeutic effect and anti-inflammatory mechanism of modified Shoutai pills(改良寿胎丸)against lipopolysaccharide-induced miscarriage in mice 认领 引用
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作者 LI Junwei LIU Xinyue +10 位作者 MOU Xuan XIE Hongliang GAO Yating ZHANG Aolin HE Tao YEUNG Tszching TANG Chao WU Xiaoke FAN Xiaohui WANG Chichiu LI Lu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第1期22-33,共12页
OBJECTIVE:To elucidate the anti-inflammatory mechanisms of modified Shoutai pills(改良寿胎丸,MSTP)in miscarriages,we performed transcriptome sequencing on the decidua and placental tissues of pregnancy mice.METHODS:Th... OBJECTIVE:To elucidate the anti-inflammatory mechanisms of modified Shoutai pills(改良寿胎丸,MSTP)in miscarriages,we performed transcriptome sequencing on the decidua and placental tissues of pregnancy mice.METHODS:The therapeutic effects and antiinflammatory mechanisms of MSTP were studied in mice with lipopolysaccharide(LPS)-induced miscarriage.First,the effects of MSTP on pregnancy outcomes and the maternal-fetal interface,in LPS-induced miscarriage mice were examined.RNA sequencing was used to further investigate gene expression changes in LPS-induced miscarriage mice and to assess the effects of MSTP intervention.Finally,the expression levels of inflammation-related genes in the decidua and placental tissues were determined using quantitative real-time polymerase chain reaction(q RT-PCR).RESULTS:A high dose of MSTP significantly decreased the resorption rate(P<0.05)and reduced apoptosis of the decidua and placental tissues in mice.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses showed that inflammatory and immune-related signals were enriched.q RT-PCR results confirmed that in decidual and placental tissues,MSTP reduced the gene expression levels of toll-like receptor 4(TLR4),nuclear factor kappa-B(NF-κB),c-Jun N-terminal kinase 1,p38,and tumor necrosis factor-α.CONCLUSIONS:In this study,we demonstrated that MSTP effectively prevented embryo loss with an antiinflammatory mechanism through downregulation of the TLR4-NF-κB/MAPK signaling pathway,in LPS-induced miscarriage mice model.To our knowledge,this is the first study to reveal the therapeutic mechanism of MSTP in LPS-induced miscarriage in mice. 展开更多
关键词 abortion,spontaneous NF-kappa B toll-like receptor 4 transcriptomics modified Shoutai pills
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Integrated Transcriptomic and Metabolomic Analysis Reveals the Adaptive Mechanism of Penicillium digitatum under Modified Atmosphere Packaging Based on Amino Acid Metabolism 认领 引用
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作者 HAO Shanshan WANG Zhengli +3 位作者 XU Huihui JI Nana GUO Yanyin Abbas AQLEEM 《食品科学》 EI CAS CSCD 北大核心 2026年第6期129-144,共16页
This study employed integrated multi-omics approaches to elucidate,from the perspective of amino acid metabolism,the adaptive mechanism of Penicillium digitatum under modified atmosphere packaging(MAP)conditions.Compa... This study employed integrated multi-omics approaches to elucidate,from the perspective of amino acid metabolism,the adaptive mechanism of Penicillium digitatum under modified atmosphere packaging(MAP)conditions.Comparative analysis of natural air(Air),controlled atmosphere(CA),and MAP treatments revealed that MAP upregulated the expression of the hercynylcysteine S-oxide synthase(HCSOS),aldehyde dehydrogenase(ALDH),and monoamine oxidase(MAO)genes,thereby enhancing histidine-derived ergothioneine and methionine levels,and subsequently boosting glutathione-mediated redox homeostasis.Meanwhile,MAP induced the expression of the dihydroxyacid dehydratase(DHAD),saccharopine dehydrogenase(SDH),and arginosuccinate lyase(ASL)genes,redirecting valine,lysine,and arginine into the tricarboxylic acid(TCA)cycle to fuel ATP production.MAP also enhanced ASL-mediated arginine degradation and urea cycle activity,reducing arginine accumulation when compared to CA treatment.In contrast,while MAP induced upregulated expression of the pyrroline-5-carboxylate dehydrogenase(P5CDH)and D-amino acid oxidase(DAAO)genes,CA treatment promoted proline accumulation,reflecting stress-specific metabolic flexibility.Collectively,these findings demonstrate that MAP triggers transcriptional reprogramming of amino acid metabolism to coordinate oxidative defense,energy generation,and osmotic balance.By modulating these metabolic pathways and regulatory genes under MAP conditions,fungal adaptability can be disrupted.Hence,this study provides a promising strategy for suppressing green mold development,extending the postharvest shelf life,and improving the quality of fruits and vegetables. 展开更多
关键词 amino acid metabolism multi-omics Penicillium digitatum modified atmosphere packaging postharvest pathology
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