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Clinical Observation on the Efficacy of Acupuncture Combined with Rehabilitation Training in Improving Motor Function Disorders in Patients with Cerebral Infarction-Induced Hemiplegia 认领 引用
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作者 YU Lu LI Mo 《外文科技期刊数据库（文摘版）医药卫生》 2026年第1期115-119,共5页
Objective: This study aims to explore the combined application of acupuncture treatment and systematic rehabilitation training, and to compare the effects of each intervention alone, in order to determine whether the ... Objective: This study aims to explore the combined application of acupuncture treatment and systematic rehabilitation training, and to compare the effects of each intervention alone, in order to determine whether the combined intervention has the clinical value of synergistic enhancement. Methods: From May 2023 to May 2024, a total of 90 patients with hemiplegia during the recovery period of cerebral infarction who met the established criteria were recruited. Using the principle of random allocation, all subjects were equally divided into three independent groups: each group had 30 participants. All study subjects maintained the basic neurology drug treatment plan. The acupuncture intervention focused on selecting acupoints of the Yangming meridian, the Governor Vessel acupoints, and the local acupoints on the affected side;the rehabilitation plan was formulated and implemented based on the principles of neurodevelopmental theory and task-oriented concepts;the combined group simultaneously executed both sets of plans. The total intervention period was 8 weeks. The primary outcome indicators were evaluated using the simplified Fugl-Meyer Scale (FMA) for assessing limb motor function;secondary indicators included the Modified Barthel Index (MBI), the National Institutes of Health Stroke Scale (NIHSS), and objective walking parameters collected by the gait analyzer. Results: After 8 weeks of intervention, data analysis showed that the FMA scores and MBI scores of patients in all three groups significantly improved, while the NIHSS score showed a downward trend. There were statistically significant differences both within and between groups. However, further comparisons between groups revealed that the improvement in all functional score scales in the combined intervention group was significantly greater than that in the acupuncture group or the rehabilitation group that received only one type of treatment, and this difference was statistically significant. Conclusio 展开更多
关键词 cerebral infarction hemiplegia acupuncture rehabilitation therapy motor function Barthel Index
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The Impact of Guidance on Limb Function Exercises on the Recovery of Motor Function in Patients with Cerebral Infarction 认领 引用
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作者 Yan Zhu 《Journal of Clinical and Nursing Research》 2026年第6期383-389,共7页
Objective:To investigate the clinical value of guidance on limb function exercises in the rehabilitation of patients with cerebral infarction,providing objective data support for optimizing rehabilitation plans during... Objective:To investigate the clinical value of guidance on limb function exercises in the rehabilitation of patients with cerebral infarction,providing objective data support for optimizing rehabilitation plans during the recovery period and enhancing overall rehabilitation outcomes.Methods:This study selected 114 patients with cerebral infarction admitted to our hospital from June 2024 to January 2026.They were randomly divided into a control group and an observation group,with 57 patients in each group.The control group received basic rehabilitation training,while the observation group received specialized guidance on limb function exercises in addition to basic rehabilitation training.Motor function,self-care ability,neurological function,and activities of daily living were compared between the two groups.Results:Compared to before the intervention,scores for motor function,self-care ability,and activities of daily living increased in both groups after the intervention,with higher scores in the observation group.Neurological function scores decreased in both groups,with lower scores in the observation group(all p<0.05).Conclusion:Combining systematic guidance on limb function exercises with basic rehabilitation training can effectively improve motor and neurological functions,as well as enhance self-care ability and activities of daily living in patients with cerebral infarction. 展开更多
关键词 Cerebral infarction Limb function Exercise Guidance Motor function
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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise 认领 引用 被引量：3
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作者 Do-Hun Lee Dan Cao +4 位作者 Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第3期836-844,共9页
Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery ... Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury. 展开更多
关键词 behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise
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Noninvasive electrodiagnostic and motor function assessment of the common fibular nerve regeneration in the rabbit hindlimb 认领 引用
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作者 Olivier Larrivée Alexane Thibodeau +4 位作者 Rosemarie Rinfret-Paquet Todd Galbraith Oumayma Hayouni Hélène TKhuong François Berthod 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第11期2080-2090,共11页
Background:Although widely used,the rat model remains poorly transferable to humans for peripheral nerve regeneration studies.The rabbit is a much better choice from an anatomical perspective.However,it remains little... Background:Although widely used,the rat model remains poorly transferable to humans for peripheral nerve regeneration studies.The rabbit is a much better choice from an anatomical perspective.However,it remains little used due to the lack of available literature.The aim of this article is to demonstrate the feasibility and effectiveness of an electrophysiological protocol combined with a motor function assessment to analyze nerve repair.Methods:Ten white New Zealand rabbits underwent a 4 cm transection of the fibular nerve.Autograft regeneration over 36 weeks was compared to non-repaired controls.The compound muscle action potential(CMAP)was recorded in the tibialis anterior and the extensor digitorum brevis.An electromyogram(EMG)was obtained after needle insertion and resting muscle activity recording.The electrophysiological results were compared to the toe spread index(TSI),which assesses the motor functional recovery promoted by fibular nerve regeneration.Results:The autograft group regeneration starts between weeks 18 and 21 and normal EMG was observed around the 30th week.These electrophysiological results were compared to the well-defined toe spread reflex.This motor test showed a significant functional return of 59%at 36 weeks(p<0.05).Rabbits regain nearly 80%of their muscle mass.Conclusion:Nerve conduction allows detection of nerve regeneration of the muscle while electromyography indicates when muscle activity returns to normal.These studies are reliable and non-invasive techniques to evaluate fibular nerve regeneration in the rabbit's hindlimb.Nonetheless,it is necessary to have qualified personnel,since inter-manipulator variations have been observed. 展开更多
关键词 denervation electromyogram fibular(peroneal)nerve motor function nerve conduction
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Link of gray matter volume to cognitive and motor function in elderly patients with mild cognitive impairment 认领 引用 被引量：1
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作者 Yue-Bing Yue Man-Fei Xu +3 位作者 Zheng Xu Jian-Xia Xu Min Lin Yi Yang 《World Journal of Psychiatry》 SCIE 2025年第4期51-59,共9页
BACKGROUND Mild cognitive impairment(MCI)is a transitional state between normal aging and Alzheimer's disease(AD),characterized by subtle cognitive decline.Amnestic MCI(aMCI),in particular,is a critical precursor ... BACKGROUND Mild cognitive impairment(MCI)is a transitional state between normal aging and Alzheimer's disease(AD),characterized by subtle cognitive decline.Amnestic MCI(aMCI),in particular,is a critical precursor often progressing to AD.There is growing interest in understanding the neuroanatomical correlates of aMCI,especially the role of gray matter volume(GMV)in cognitive and motor function decline.This study hypothesized that aMCI patients will exhibit reduced GMV,particularly in brain regions associated with cognition and motor control,impacting both cognitive performance and motor abilities.AIM To investigate the association of GMV with cognitive and motor functions in aMCI.METHODS In this cross-sectional study conducted from March 2022 to March 2024,45 aMCI patients and 45 normal controls from our Department of Geratology were enrolled.Voxel-based morphometry was used to compare GMV between groups.Correlation of differential GMV with cognitive scores and gait parameters was assessed via partial correlation analysis.Linear regression was used to assess associations between whole-brain GMV and gait measures.RESULTS GMV of aMCI region of interest(ROI)1 and ROI2 was negatively correlated with Activities of Daily Living(ADL)score.GMV of ROI6 was positively correlated with the total scores of Mini-Mental State Examination and Cambridge Cognitive Examination-Chinese Version(CAMCOG-C)and negatively correlated with ADL score.In the partial correlation analysis of cognitive and motor function parameters,age,gender,educational level,height,and weight were controlled,and the results showed that CAMCOG-C was negatively correlated with Dual Task of Time Up and Go Test(TUG)duration in the aMCI group.The volume of the left occipital gray matter in the aMCI group was negatively correlated with TUG.GMV of the bilateral frontal gyrus,right orbitofrontal gyrus,right occipital cleft,right supraoccipital gyrus,and left anterior central gyrus was positively correlated with walking speed.CONCLUSION GMV reduction in aMCI correlates with impaired cognition and motor function,emphasizing key roles for prefrontal,occipital,and central regions in gait disorders. 展开更多
关键词 Amnestic mild cognitive impairment Gray matter volume Voxel-based morphometry Alzheimer's disease Motor function
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Evaluation of Task-Oriented Training Combined with Lower Limb Rehabilitation Robot on Improvement of Motor Function and Ankle Joint Function in Stroke Patients with Hemiplegia 认领 引用 被引量：1
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作者 Xingjun Shi 《Journal of Clinical and Nursing Research》 2025年第8期332-338,共7页
Objective:To evaluate the effect of task-oriented training combined with a lower limb rehabilitation robot on improving motor function and ankle joint function in stroke patients with hemiplegia.Methods:Sixty-three st... Objective:To evaluate the effect of task-oriented training combined with a lower limb rehabilitation robot on improving motor function and ankle joint function in stroke patients with hemiplegia.Methods:Sixty-three stroke patients with hemiplegia admitted to our hospital from January 2022 to June 2024 were randomly divided into observation group(32 cases)and control group(31 cases)using the envelope method.The control group received task-oriented training,while the observation group received additional lower limb rehabilitation robot training.The motor function(Fugl-Meyer Assessment of Lower Extremity,FMA-LE)and ankle joint function(Active Dorsiflexion Range of Motion,DF AROM)were compared between the two groups.Results:After treatment,the levels of FMA-LE and DF AROM in both groups increased significantly,and the improvement in each index in the observation group was better than that in the control group(P<0.05).Conclusion:The combination of task-oriented training and lower limb rehabilitation robot training can more effectively improve the overall motor function of the lower limbs and the active dorsiflexion ability of the ankle joint in stroke patients with hemiplegia. 展开更多
关键词 Stroke Hemiplegia Task-oriented training Lower limb rehabilitation robot Motor function Ankle joint function
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Comparative Effect of Balance Rhythm Dance and Aerobics on Motor Function Rehabilitation in Elderly Women 认领 引用
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作者 Shanshan Zhang Xiuli Yu +5 位作者 Kai Gao Runli Yang Liu Ren Ye Yuan Xuefan Li Jun Shen 《Journal of Clinical and Nursing Research》 2025年第1期132-138,共7页
Objective: To investigate the effect of a self-developed balance rhythm dance program on the rehabilitation of motor function and the reduction of fall risk in elderly women with diminished balance function. Methods: ... Objective: To investigate the effect of a self-developed balance rhythm dance program on the rehabilitation of motor function and the reduction of fall risk in elderly women with diminished balance function. Methods: Fifty elderly women with reduced balance function, admitted to the Qingbar Elderly Care Center of Chongqing Medical University from December 2022 to December 2023, were randomly selected and divided into two groups. The aerobic exercise group (25 patients) received traditional treatment and rehabilitation nursing, while the balance rhythm dance intervention group (25 patients) received the balance rhythm dance intervention in addition to traditional treatment and rehabilitation nursing. The Unified Parkinson’s Disease Rating Scale (UPDRS) and Berg Balance Scale (BBS) were used as evaluation indicators to compare the intervention effects between the two groups. Results: The data revealed that the balance rhythm dance intervention significantly improved the motor ability and balance function of elderly women in the intervention group (P < 0.01), with statistically significant differences observed. Conclusion: The balance rhythm dance program plays a critical role in promoting the rehabilitation of motor function and balance ability in elderly women, effectively enhancing their quality of life. 展开更多
关键词 Balance rhythm dance Fall risk Eldery women Motor function
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Rebuilding motor function of the spinal cord based on functional electrical stimulation 认领 引用 被引量：3
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作者 Xiao-yan Shen Wei Du +1 位作者 Wei Huang Yi Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第8期1327-1332,共6页
Rebuilding the damaged motor function caused by spinal cord injury is one of the most serious challenges in clinical neuroscience.The function of the neural pathway under the damaged sites can be rebuilt using functio... Rebuilding the damaged motor function caused by spinal cord injury is one of the most serious challenges in clinical neuroscience.The function of the neural pathway under the damaged sites can be rebuilt using functional electrical stimulation technology.In this study,the locations of motor function sites in the lumbosacral spinal cord were determined with functional electrical stimulation technology.A three-dimensional map of the lumbosacral spinal cord comprising the relationship between the motor function sites and the corresponding muscle was drawn.Based on the individual experimental parameters and normalized coordinates of the motor function sites,the motor function sites that control a certain muscle were calculated.Phasing pulse sequences were delivered to the determined motor function sites in the spinal cord and hip extension,hip flexion,ankle plantarflexion,and ankle dorsiflexion movements were successfully achieved.The results show that the map of the spinal cord motor function sites was valid.This map can provide guidance for the selection of electrical stimulation sites during the rebuilding of motor function after spinal cord injury. 展开更多
关键词 nerve regeneration spinal cord injury functional electrical stimulation rebuilding motor function movement control spinal cord lumbosacral spinal cord motor function sites hip extension movement hip flexion movement ankle plantarflexion ankle dorsiflexion neural regeneration
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Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke:a systematic review and network meta-analysis 认领 引用 被引量：42
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作者 Yun-Juan Xie Yi Chen +3 位作者 Hui-Xin Tan Qi-Fan Guo Benson Wui-Man Lau Qiang Gao 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第6期1168-1176,共9页
Transcranial magnetic stimulation,a type of noninvasive brain stimulation,has become an ancillary therapy for motor function rehabilitation.Most previous studies have focused on the effects of repetitive transcranial ... Transcranial magnetic stimulation,a type of noninvasive brain stimulation,has become an ancillary therapy for motor function rehabilitation.Most previous studies have focused on the effects of repetitive transcranial magnetic stimulation(rTMS)on motor function in stroke patients.There have been relatively few studies on the effects of different modalities of rTMS on lower extremity motor function and corticospinal excitability in patients with stroke.The MEDLINE,Embase,Cochrane Library,ISI Science Citation Index,Physiotherapy Evidence Database,China National Knowledge Infrastructure Library,and ClinicalTrials.gov databases were searched.Parallel or crossover randomized controlled trials that addressed the effectiveness of rTMS in patients with stroke,published from inception to November 28,2019,were included.Standard pairwise meta-analysis was conducted using R version 3.6.1 with the“meta”package.Bayesian network analysis using the Markov chain Monte Carlo algorithm was conducted to investigate the effectiveness of different rTMS protocol interventions.Network meta-analysis results of 18 randomized controlled trials regarding lower extremity motor function recovery revealed that low-frequency rTMS had better efficacy in promoting lower extremity motor function recovery than sham stimulation.Network meta-analysis results of five randomized controlled trials demonstrated that highfrequency rTMS led to higher amplitudes of motor evoked potentials than low-frequency rTMS or sham stimulation.These findings suggest that rTMS can improve motor function in patients with stroke,and that low-frequency rTMS mainly affects motor function,whereas high-frequency rTMS increases the amplitudes of motor evoked potentials.More highquality randomized controlled trials are needed to validate this conclusion.The work was registered in PROSPERO(registration No.CRD42020147055)on April 28,2020. 展开更多
关键词 cortical excitability lower extremity motor function network meta-analysis noninvasive brain stimulation stroke systematic review transcranial magnetic stimulation
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Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury 认领 引用 被引量：32
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作者 Si-Si Li Xu-Yun Hua +6 位作者 Mou-Xiong Zheng Jia-Jia Wu Zhen-Zhen Ma Xiang-Xin Xing Jie Ma Chun-Lei Shan Jian-Guang Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第7期1545-1555,共11页
Electroacupuncture(EA)has been widely used for functional restoration after stroke.However,its role in post-stroke rehabilitation and the associated regulatory mechanisms remain poorly understood.In this study,we appl... Electroacupuncture(EA)has been widely used for functional restoration after stroke.However,its role in post-stroke rehabilitation and the associated regulatory mechanisms remain poorly understood.In this study,we applied EA to the Zusanli(ST36)and Quchi(LI11)acupoints in rats with middle cerebral artery occlusion and reperfusion.We found that EA effectively increased the expression of brain-derived neurotrophic factor and its receptor tyrosine kinase B,synapsin-1,postsynaptic dense protein 95,and microtubule-associated protein 2 in the ischemic penumbra of rats with middle cerebral artery occlusion and reperfusion.Moreover,EA greatly reduced the expression of myelin-related inhibitors Nogo-A and NgR in the ischemic penumbra.Tyrosine kinase B inhibitor ANA-12 weakened the therapeutic effects of EA.These findings suggest that EA can improve neurological function after middle cerebral artery occlusion and reperfusion,possibly through regulating the activity of the brain-derived neurotrophic factoryrosine kinase B signal pathway.All procedures and experiments were approved by the Animal Research Committee of Shanghai University of Traditional Chinese Medicine,China(approval No.PZSHUTCM200110002)on January 10,2020. 展开更多
关键词 brain-derived neurotrophic factor dendritic electroacupuncture ischemiaeperfusion motor function neurite outgrowth inhibitor-A neurological outcomes Nogo receptor synapse tyrosine kinase B
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Combined Transplantation of Neural Stem Cells and Olfactory Ensheathing Cells Improves the Motor Function of Rats with Intracerebral Hemorrhage 认领 引用 被引量：18
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作者 ZHOU-PING TANG Xue-WE XIE +4 位作者 YUAN-HONG SHI NA LIU SUI-QIANG ZHU ZAI-WANo LI YUN CHEN 《Biomedical and Environmental Sciences》 SCIE CAS 2010年第1期62-67,共6页
Objective To investigate the effects of combined transplantation of neural stem cells(NSC)and olfactory ensheathing cells(OEC)on the motor function of rats with intracerebral hemorrhage.Methods In three days after a r... Objective To investigate the effects of combined transplantation of neural stem cells(NSC)and olfactory ensheathing cells(OEC)on the motor function of rats with intracerebral hemorrhage.Methods In three days after a rat model of caudate nucleus hemorrhage was established,NSCs and OEC,NSC,OEC(from embryos of Wistar rats)or normal saline were injected into bematomas of rats in combined transplantation group,NSC group,OEC group,and control group,respectively.Damage of neural function was scored before and in 3,7,14,30 days after operation.Tissue after transplantation was observed by immunocytochemistry staining.Results The scores for the NSC,OEC and co-transplantation groups were significantly lower in 14 and 30 days after operation than in 3 days after operation(P〈0.05).The scores for the NSC and OEC groups were significantly lower than those for the control group only in 30 days after operation(P〈0.05),while the difference for the NSC-OEC group was significant in 14 days after operation(P〈0.05).Immunocytochemistry staining revealed that the transplanted OEC and NSC could survive,migrate and differentiate into neurons,astrocytes,and oligodendrocytes.The number of neural precursor cells was greater in the NSC and combined transplantation groups than in the control group.The number of neurons differentiated from NSC was significantly greater in the co-transplantation group than in the NSC group.Conclusion Co-transplantation of NSC and OEC can promote the repair of injured tissue and improve the motor fimction of rats with intracerebral hemorrhage. 展开更多
关键词 Stem cell Olfactory bulb Cell transplantation Intracerebral hemorrhage Motor function
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Efficacy of meridian massage for motor function after a stroke: a systematic review and Meta-analysis 认领 引用 被引量：14
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作者 XIE Yunhui GU Hao +4 位作者 ZHAO Qing LI Dejie GONG Ying XIE Junxing SHI Guofeng 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2022年第3期321-331,共11页
OBJECTIVE:To evaluate the efficacy of meridian massage on motor function after a stroke.METHODS:This systematic review and Meta-analysis of randomised(RCTs)and quasi-randomised controlled trials(q RCTs)was performed t... OBJECTIVE:To evaluate the efficacy of meridian massage on motor function after a stroke.METHODS:This systematic review and Meta-analysis of randomised(RCTs)and quasi-randomised controlled trials(q RCTs)was performed to determine the effects of meridian massage on motor dysfunction following a stroke.Articles published until December 2020 related to stroke and meridian massage from National Library of Medicine,Cochrane Central Register of Controlled Trials,Embase,Korea Med,Japan science and Technology Agency,China National Knowledge Infrastructure Database,Wanfang Database,Chinese Biomedical Literature Database and China Science and Technology Journal Database were searched.The primary outcomes included Fugl-Mayer Assessment(FMA),modified Barthel Index(m BI)and clinical efficiency,while the secondary outcomes included modified Ashworth(m AS)and Berg Balance Scale(BBS).Two authors independently selected the literature,extracted the data and assessed the risk of bias,after which Meta-analysis with subgroups and sensitivity analysis was conducted.RESULTS:A total of 16 RCTs and 3 q-RCTs involved 1556 patients satisfied the inclusion.Meta-analysis showed that compared to conventional rehabilitation,meridian massage had significantly better FMA[mean difference(MD)=1.16,95%confidence interval(CI):0.43,1.89,P=0.002],FMA-L(MD=3.21,95%CI:1.97,4.45,P=0.00001),m BI(MD=8.87,95%CI:4.24,13.49,P=0.00002),clinical efficiency[relative risk(RR)=1.37,95%CI:1.24,1.51,P8 weeks(MD=0.89,95%CI:-0.64,2.42,P=0.25)but improving motor function in the meridian massage when the intervention duration was≤8 weeks(<4 weeks intervention duration MD=0.84,95%CI:0.59,1.10,P<0.00001;4–8 weeks MD=2.41,95%CI:0.80,4.01,P=0.003).CONCLUSIONS:Meridian massage as an alternative and complementary therapy seems to have short-term benefits in improving post-stroke motor function(particularly in the lower limbs),quality of life,clinical efficiency,and balance stability and muscle spasms.The high heterogeneity of the included studies and the low methodological quality certainly limits the confidence placed in this systematic review and Meta-analysis,warranting future well-designed studies. 展开更多
关键词 stroke meridian massage motor function Meta-analysis randomized controlled trial
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Transcranial pulse current stimulation improves the locomotor function in a rat model of stroke 认领 引用 被引量：12
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作者 Wen-Jing Wang Yan-Biao Zhong +6 位作者 Jing-Jun Zhao Meng Ren Si-Cong Zhang Ming-Shu Xu Shu-Tian Xu Ying-Jie Zhang Chun-Lei Shan 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第7期1229-1234,共6页
Previous studies have shown that transcranial pulse current stimulation(tPCS) can increase cerebral neural plasticity and improve patients' locomotor function.However, the precise mechanisms underlying this effect... Previous studies have shown that transcranial pulse current stimulation(tPCS) can increase cerebral neural plasticity and improve patients' locomotor function.However, the precise mechanisms underlying this effect remain unclear.In the present study, rat models of stroke established by occlusion of the right cerebral middle artery were subjected to tPCS, 20 minutes per day for 7 successive days.tPCS significantly reduced the Bederson score, increased the foot print area of the affected limbs, and reduced the standing time of affected limbs of rats with stroke compared with that before intervention.Immunofluorescence staining and western blot assay revealed that tPCS significantly increased the expression of microtubule-associated protein-2 and growth-associated protein-43 around the ischemic penumbra.This finding suggests that tPCS can improve the locomotor function of rats with stroke by regulating the expression of microtubule-associated protein-2 and growth-associated protein-43 around the ischemic penumbra.These findings may provide a new method for the clinical treatment of poststroke motor dysfunction and a theoretical basis for clinical application of tPCS.The study was approved by the Animal Use and Management Committee of Shanghai University of Traditional Chinese Medicine of China(approval No.PZSHUTCM190315003) on February 22, 2019. 展开更多
关键词 motor function neural plasticity non-invasive brain stimulation protection repair stroke transcranial pulse current stimulation
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Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation 认领 引用 被引量：11
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作者 Dan Zhao Ye Zhang +5 位作者 Ya Zheng Xu-Tong Li Cheng-Cheng Sun Qi Yang Qing Xie Dong-Sheng Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第5期1062-1066,共5页
Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In... Multi-target neural circuit-magnetic stimulation has been clinically shown to improve rehabilitation of lower limb motor function after spinal cord injury. However, the precise underlying mechanism remains unclear. In this study, we performed double-target neural circuit-magnetic stimulation on the left motor cortex and bilateral L5 nerve root for 3 successive weeks in a rat model of incomplete spinal cord injury caused by compression at T10. Results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. Additionally, neural signaling of the descending corticospinal tract was markedly improved and rat locomotor function recovered significantly. These findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury. 展开更多
关键词 astrocyte inflammatory response microtubule-associated protein 2 motor function motor-evoked potential neural circuit-magnetic stimulation neural repair neuromodulation technique spinal cord injury synaptic plasticity
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Total flavonoids of hawthorn leaves promote motor function recovery via inhibition of apoptosis after spinal cord injury 认领 引用 被引量：11
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作者 Qiong Zhang Yin Xiong +5 位作者 Bo Li Gui-Ying Deng Wen-Wen Fu Bai-Chuan Cao Shao-Hui Zong Gao-Feng Zeng 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第2期350-356,共7页
Flavonoids have been reported to have therapeutic potential for spinal cord injury.Hawthorn leaves have abundant content and species of total flavonoids,and studies of the effects of the total flavonoids of hawthorn l... Flavonoids have been reported to have therapeutic potential for spinal cord injury.Hawthorn leaves have abundant content and species of total flavonoids,and studies of the effects of the total flavonoids of hawthorn leaves on spinal cord injury have not been published in or outside China.Therefore,Sprague-Dawley rats were used to establish a spinal cord injury model by Allen's method.Rats were intraperitoneally injected with 0.2 m L of different concentrations of total flavonoids of hawthorn leaves(5,10,and 20 mg/kg)after spinal cord injury.Injections were administered once every 6 hours,three times a day,for 14 days.After treatment with various concentrations of total flavonoids of hawthorn leaves,the Basso,Beattie,and Bresnahan scores and histological staining indicated decreases in the lesion cavity and number of apoptotic cells of the injured spinal cord tissue;the morphological arrangement of the myelin sheath and nerve cells tended to be regular;and the Nissl bodies in neurons increased.The Basso,Beattie,and Bresnahan scores of treated spinal cord injury rats were increased.Western blot assays showed that the expression levels of pro-apoptotic Bax and cleaved caspase-3 were decreased,but the expression level of the anti-apoptotic Bcl-2 protein was increased.The improvement of the above physiological indicators showed a dose-dependent relationship with the concentration of total flavonoids of hawthorn leaves.The above findings confirm that total flavonoids of hawthorn leaves can reduce apoptosis and exert neuroprotective effects to promote the recovery of the motor function of rats with spinal cord injury.This study was approved by the Ethics Committee of the Guangxi Medical University of China(approval No.201810042)in October 2018. 展开更多
关键词 apoptosis Bax protein Bcl-2 protein cleaved caspase-3 inflammation motor function recovery neuroprotection Nissl bodies spinal cord injury total flavonoids of hawthorn leaves
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Knockdown of polypyrimidine tract binding protein facilitates motor function recovery after spinal cord injury 认领 引用 被引量：5
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作者 Ri-Yun Yang Rui Chai +7 位作者 Jing-Ying Pan Jing-Yin Bao Pan-Hui Xia Yan-Kai Wang Ying Chen Yi Li Jian Wu Gang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第2期396-403,共8页
After spinal cord injury(SCI),a fibroblast-and microglia-mediated fibrotic scar is formed in the lesion core,and a glial scar is formed around the fibrotic scar as a res ult of the activation and proliferation of astr... After spinal cord injury(SCI),a fibroblast-and microglia-mediated fibrotic scar is formed in the lesion core,and a glial scar is formed around the fibrotic scar as a res ult of the activation and proliferation of astrocytes.Simultaneously,a large number of neuro ns are lost in the injured area.Regulating the dense glial scar and re plenishing neurons in the injured area are essential for SCI repair.Polypyrimidine tra ct binding protein(PTB),known as an RNA-binding protein,plays a key role in neurogenesis.Here,we utilized short hairpin RNAs(shRNAs)and antisense oligonucleotides(ASOs)to knock down PTB expression.We found that reactive spinal astrocytes from mice were directly reprogrammed into motoneuron-like cells by PTB downregulation in vitro.In a mouse model of compressioninduced SCI,adeno-associated viral shRNA-mediated PTB knockdown replenished motoneuron-like cells around the injured area.Basso Mouse Scale scores and forced swim,inclined plate,cold allodynia,and hot plate tests showed that PTB knockdown promoted motor function recovery in mice but did not improve sensory perception after SCI.Furthermore,ASO-mediated PTB knockdown improved motor function resto ration by not only replenishing motoneuron-like cells around the injured area but also by modestly reducing the density of the glial scar without disrupting its overall structure.Together,these findings suggest that PTB knockdown may be a promising therapeutic strategy to promote motor function recovery during spinal cord repair. 展开更多
关键词 antisense oligonucleotides astrocytes glial scar motoneuron-like cells motor function neurogenesis neuron-like cells polypyrimidine tract binding protein short hairpin RNAs spinal cord repair
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Biofeedback therapy improves motor function following stroke Meta-analysis of 14 articles from Chinese Medical Institutions 认领 引用 被引量：3
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作者 Yang Tian Lianguo Kang +1 位作者 Hongying Wang Zhenyi Liu 《Neural Regeneration Research》 SCIE CAS 2010年第7期538-544,共7页
OBJECTIVE： To evaluate feasibility of biofeedback therapy in China Medical Institutions to improve dysfunction following stroke. DATA SOURCE： A computer-based online search of publications was conducted using the Vi... OBJECTIVE： To evaluate feasibility of biofeedback therapy in China Medical Institutions to improve dysfunction following stroke. DATA SOURCE： A computer-based online search of publications was conducted using the Vip and PubMed Databases to identify publications that addressed biofeedback. The search key words included ＂electromyogram＂, ＂biofeedback＂, and ＂stroke＂. In total, 81 articles were retrieved. DATA SELECTION： Studies closely related to biofeedback, or studies with contents recently published in the same study field or in authorized journals, were included. Duplicated articles were excluded. Following full-text retrieval of selected articles, a total of 14 articles were collected, which addressed randomized, controlled trials of biofeedback therapy for dysfunction after stroke. Methodological quality was assessed for randomized, controlled trials using criteria from Cochrane reviewers＇ handbook. Results were analyzed using Revman 4.2 software. MAIN OUTCOME MEASURES： Outcomes and evaluation indices were expressed by odds ratio （OR）, weighted mean difference （WMD）, and 95% confidence interval （95% CO. Potential publication bias was presented using the funnel plot. RESULTS： The study included 14 randomized, controlled trials of 1 147 patients. Following biofeedback therapy, meta-analysis results demonstrated that： （1） The total effective rate was significantly greater in the biofeedback therapy group compared with the control group [OR = 3.46, 95% Cl （2.09, 5.73）, P = 0.62]. （2） Electromyogram changes were better in biofeedback therapy patients compared to the control group [WMD= 22.31, 95% C/（17.19, 27.43）, P〈 0.001]. （3） Motor function was better in biofeedback therapy patients compared with the control group [WMD = 12.43, 95% CI （6.71, 18.16）, P 〈 0.001]. （4） Daily living activities were better in biofeedback therapy patients compared with the control group [WMD= 18.11, 95% C/（15.77, 20.44）, P= 0.36]. （5） Joint range of motion was better in biofeedback therapy patients compared with the control group [WMD = 6.43, 95% Cl （4.44, 8.41）, P = 0.77]. Sensitivity analysis also demonstrated similar results after eliminating articles that described unknown diagnostic criteria and statistical methods. CONCLUSION： Following stroke, biofeedback therapy for dysfunction was shown to result in significant and valid outcomes, increased motor function and electromyogram values, improved joint range of motion, and improved daily living activities. 展开更多
关键词 motor function electromyogram biofeedback stroke meta-analysis Chinese Medical Institations： China
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Electro-acupuncture at Zusanli(ST 36)to improve lower extremity motor function in sensory disturbance patients with cerebral stroke A randomized controlled study of 240 cases 认领 引用 被引量：3
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作者 Weijun Gong Tong Zhang +2 位作者 Lihua Cui YuqiYang Xinting Sun 《Neural Regeneration Research》 SCIE CAS 2009年第11期935-940,共6页
BACKGROUND:Studies have shown that sensory transduction is a way to introduce needle sensation.OBJECTIVE:To observe the influence of electro-acupuncture at the"Zusanll"(ST 36)point on lower extremity motor f... BACKGROUND:Studies have shown that sensory transduction is a way to introduce needle sensation.OBJECTIVE:To observe the influence of electro-acupuncture at the"Zusanll"(ST 36)point on lower extremity motor function in various sensory disturbance patients with cerebral stroke.DESIGN,TIME AND SETTING:A randomized,controlled,clinical study was performed at the Department of Neurological Rehabilitation,China Rehabilitation Research Centre from September 2006 to June 2008.PARTICIPANTS:Patients with first-time cerebral infarction or hemorrhage,or with a stroke history,but no neurodysfunction(single damage),were selected for this study.The subjects were right-handed and disease state was stable.A total of 240 inpatients were randomly assigned to the following groups:electro-acupuncture(n=124)and control(n=116).The two groups were further assigned into sub-groups:no sensory disturbance,superficial sensory disturbance,deep sensory disturbance,and deep and superficial sensory disturbance.METHODS:On the basis of routine limb function training,the acupoint Zusanliwas utilized in all patients from the electro-acupuncture group.Perpendicular acupuncture was 3.0-4.0 cm deep.An electric acupuncture instrument was connected when patients developed the needle sensation,deqi.A stimulation pattern consisting of distant and dense waves of 50 Hz was used to elicit slight dorsal foot extension.Acupuncture was administered 5 times per week,30 minutes per session,for 6 weeks in total.MAIN OUTCOME MEASURES:FugI-Meyer assessment(FMA)was used to evaluate lower extremity motor function;Ver.1.0 gait analysis to estimate gait(step frequency,step speed,and step scope);lower extremity Composite Spasticity Scale(CSS)to estimate muscle spastic degree.RESULTS:Following treatment,motor function improved in both groups.Compared with the control group,FMA score,step speed,step frequency,and step scope were increased in the electro-acupuncture group,but there was no difference in lower extremity CSS scores between the electro-acupuncture and the control groups(P〉0.05).Compared with the control group,Zusanli(ST 36)electro-acupuncture improved motor function indices as follows:FMA score,step frequency,step speed,and step scope of patients with no sensory disturbance(P〈0.05-0.01),step frequency of patients with superficial sensory disturbance(P〈0.05),and step frequency and step speed of patients with deep sensory disturbance(P〈0.05).CONCLUSION:Zusanfi(ST 36)electro-acupuncture effects on lower extremity motor function in stroke patients were improved with no muscle tone rise.Therefore,this form of treatment can be used in convalescent treatment,Moreover,effects were different according to various sensory disturbance types,which suggested that sensory input influenced acupuncture effects. 展开更多
关键词 electro-acupuncture Zusanli(ST 36) sensory disturbance motor function sensory input
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Impacts of the combined treatment of Tongdu Tiaoshen moxibustion and rehabilitation training on the motor function recovery of the upper limbs in the patients with apoplectic hemiplegia 认领 引用 被引量：6
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作者 Si-fang Chen Wei Han Shan-bin Sun 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2020年第2期97-101,共5页
Objective:To observe the impacts of the combined treatment of Tongdu Tiaoshen moxibustion(moxibustion for promoting the circulation of the governor vessel and regulating the spirit)and rehabilitation training on the m... Objective:To observe the impacts of the combined treatment of Tongdu Tiaoshen moxibustion(moxibustion for promoting the circulation of the governor vessel and regulating the spirit)and rehabilitation training on the motor function recovery in the patients with apoplectic hemiplegia.Methods:A total of 50 patients with apoplectic hemiplegia and qualified in the trial recruitment criteria were divided into two groups according to random number table,25 cases in each group.In the control group,the simple rehabilitation training was provided.In the observation group,on the base of the treatment as the control group,Tongdu Tiaoshen moxibustion was given.Main acupoints:Baihul(百会GV20),Fengfu(风府GV16)and Dazhui(大椎GV14).The treatment was given once a day,6 treatments a week,4 weeks as one course and two courses of treatment were required.Before and after treatment,the scores of Fugle-Meyer assessment(FMA),the modified Barthel index(MBI)and action research arm test(ARAT)were detected before and after treatment in the two groups separately.Results:After 4 and 8 weeks of treatment,the scores of FMA,MBI and ARAT were all improved obviously as compared with those before treatment respectively in patients of the two groups(all P<0.01).After8 weeks of treatment,the score of each scale in the observation group was more obviously improved as compared with the control group(all P<0.05).The difference in the clinical therapeutic effect was significant statistically between the two groups(P=0.005).Conclusion:The combined treatment of Tongdu Tiaoshen moxibustion and rehabilitation training promotes the recovery of the upper limb motor function and improves the self-ability of living activities in the patients with apoplectic hemiplegia.The long-term effect of this combined therapy is superior to that of simple rehabilitation training. 展开更多
关键词 Tongdu Tiaoshen moxibustion Rehabilitation Apoplexy/Stroke Motor function of the upper limb
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Altered protein markers related to neural plasticity and motor function following electro-acupuncture treatment in a rat model of ischemic-hypoxic brain injury 认领 引用 被引量：2
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作者 Liping Zhang Liping Zou 《Neural Regeneration Research》 SCIE CAS 2008年第9期945-949,共5页
BACKGROUND：Previous studies have demonstrated that acupuncture treatment could ameliorate impaired motor function,and these positive effects might be due to neural plasticity.OBJECTIVE：Myelin basic protein（MBP）,mi... BACKGROUND：Previous studies have demonstrated that acupuncture treatment could ameliorate impaired motor function,and these positive effects might be due to neural plasticity.OBJECTIVE：Myelin basic protein（MBP）,microtubule-associated protein 2（MAP2）,growth-associated protein-43（GAP-43）,and synaptophysin（SYN） were selected as markers of neural remodeling,and expression of these markers was evaluated with regard to altered motor function following brain injury and acupuncture treatment.DESIGN,TIME AND SETTING：A completely randomized experiment was performed at the Central Laboratory of Peking University First Hospital from November 2006 to May 2007.MATERIALS：Twenty-four Sprague Dawley rat pups,aged 7 days,were selected for the present experiment.The left common carotid artery was ligated to establish a rat model of ischemic-hypoxic brain injury.METHODS：All animals were randomly divided into three groups：sham operation,model,and electro-acupuncture treatment,with 8 rats in each group.Rats in the model and electro-acupuncture treatment group underwent establishment of ischemic-hypoxic brain injury.Upon model established,rats underwent hypobaric oxygen intervention for 24 hours.Only the left common carotid artery was exposed in rats of the sham operation group,without model establishment or oxygen intervention.The rats in the electro-acupuncture treatment group were treated with electro-acupuncture.One acupuncture needle electrode was inserted into the subcutaneous layer at the Baihui and Dazhui acupoint.The stimulation condition of the electro-acupuncture simulator was set to an amplitude-modulated wave of 0-100% and alternative frequency of 100 cycles/second,as well as frequency-modulated wave of 2-100 Hz and an alternative frequency of 3 cycles/second.Maximal current through the two electrodes was limited to 3-5 mA.The stimulation lasted for 30 minutes per day for 2 weeks.Rats in the sham operation and model groups were not treated with electro-acupuncture,but only fixed to the table for the same time period.MAIN OUTCOME MEASURES：After 2 weeks stimulation,expression of MBP,MAP2,GAP-43,and SYN were detected in the brain by immunohistochemistry.Motor function was evaluated in the three groups.RESULTS：In the sham operation group,MBP was abundant in the myelinated nerve fibers.In the electro-acupuncture treatment group,however,the corpus callosum exhibited more MBP staining than the model group.MAP2 expression was increased in the model group,and increased further in the electro-acupuncture treatment group compared with the sham operation group.GAP-43 expression in the cerebral cortex was less in model group than in sham operation,but present in abundance in the electro-acupuncture treatment group.SYN expression in the cerebral cortex was less in the model and electro-acupuncture treatment group compared with the sham operation group.There was no significant difference in SYN expression and distribution between the model and electro-acupuncture treatment groups.Motor function of rats in the electro-acupuncture treatment group was significantly better than the model group（P 〈 0.05）,although function remained lower than the sham operation group（P 〈 0.05）.CONCLUSION：Two weeks of electro-acupuncture treatment improved motor function in rats,and protein markers related to neural plasticity also changed,which may be a mechanism for improved motor function in rats with ischemic-hypoxic brain injury. 展开更多
关键词 acupuncture ischemic-hypoxic brain injury motor function neural plasticity
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