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Outcomes in octogenarians undergoing percutaneous coronary intervention:nationwide data from the Netherlands Heart Registration 认领 引用
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作者 Nousjka PA Vranken Sanne Janssen +5 位作者 Tobias FS Pustjens Romi Michon Lineke Derks Arnoud WJ van’t Hof Saman Rasoul the PCI and Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第1期1-8,共8页
Background In patients with coronary artery disease,age is of known significance in predicting outcomes.Data on clinical outcomes in patients≥85 years undergoing percutaneous coronary intervention(PCI)remain scarce.T... Background In patients with coronary artery disease,age is of known significance in predicting outcomes.Data on clinical outcomes in patients≥85 years undergoing percutaneous coronary intervention(PCI)remain scarce.The study aim was to determine clinical characteristics,risk of adverse cardiovascular events,and mortality in patients aged≥85 years compared to those aged<85 undergoing PCI.Methods In this retrospective study,data were obtained from the nationwide Netherlands Heart Registration on patients undergoing PCI between January 1st,2017 and January 1st,2021.The primary endpoint was all-cause mortality at long-term followup.Results A total of 155,683 patients underwent PCI,of which 100,209(64.4%)acute coronary syndrome cases.Compared to patients aged<85 years,patients aged≥85 were more often female and showed a higher number of cardiovascular comorbidities,including impaired left ventricle ejection fraction and reduced kidney function.Mortality at short-term and long-term follow-up were significantly higher in those aged≥85(P<0.001).Patients aged≥85 were more likely to have a myocardial infarction within 30 days following the index intervention(0.9%vs.0.7%;P=0.024),though they less often underwent revascularization at longterm follow-up compared to patients aged<85(P<0.001).Conclusions The elderly(≥85 years)patient requiring PCI carries an extensive cardiovascular risk profile,translating in significant risk of recurrent cardiovascular events and increased mortality rate.Clinicians should carefully weigh perceived risks and potential benefits in the individual patient,considering the patients’age,cardiovascular risk profile,and associated risk of morbidity and mortality. 展开更多
关键词 Octogenarians coronary artery diseaseage Clinical Characteristics percutaneous coronary intervention pci remain Adverse Cardiovascular Events Mortality Percutaneous Coronary Intervention
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Examining short-term and long-term outcomes in octogenarians undergoing isolated surgical aortic valve replacement 认领 引用
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作者 Marcus Taylor Antony Walker +1 位作者 David Rose Mohamad N Bittar 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第4期228-234,共7页
BACKGROUND As the transcatheter approach to aortic valve disease become more common,the role of surgical aortic valve replacement(SAVR),particularly in older patients,is increasingly contentious.This study aimed to ex... BACKGROUND As the transcatheter approach to aortic valve disease become more common,the role of surgical aortic valve replacement(SAVR),particularly in older patients,is increasingly contentious.This study aimed to examine short-term and long-term outcomes in octogenarians undergoing isolated SAVR.METHODS All consecutive patients aged 80 years and over undergoing isolated first-time SAVR in two cardiac surgery centres between 1997 and 2019 were included.Primary outcomes were in-hospital,1-year and 5-year mortality and overall survival.Secondary outcomes were re-exploration,post-operative renal replacement therapy,post-operative stroke,post-operative permanent pacemaker implantation and post-operative length of stay(PLOS).The multivariate Cox regression analysis was used to identify variables independently associated with overall survival.RESULTS The study comprised 524 patients,which represented 14.9%of all isolated SAVRs performed during the study period(n=524/3516).Mean age was 83.2±2.7 years and 28.1%of patients(n=147)were aged 85 years and above.59.0%of patients(n=309)were female.There were 11.1%of patients(n=58)who underwent minimally invasive surgery and mean logistic EuroSCORE was 12.1%±6.6%.Median PLOS was 9(7-14)days.Overall in-hospital,1-year and 5-year mortality were 4.2%(n=22),9.7%(n=51)and 34.5%(n=181),respectively.For patients who survived to hospital discharge,1-year survival was 94.2%(n=473/502).Median follow-up time was 77(44-101)months and estimated median overall survival was 81(76-86)months.CONCLUSIONS SAVR remains a safe operation in octogenarian patients.Findings from this study suggest that for appropriately selected patients,SAVR can provide durable long-term benefit and should still be considered an appropriate treatment strategy. 展开更多
关键词 octogenarians long term outcomes short term outcomes transcatheter approach cardiac surgery isolated surgical aortic valve replacement transcatheter aortic valve replacement surgical aortic valve replacement savr particularly
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Survival outcomes with pelvic node dissection after partial cystectomy among octogenarians with muscle-invasive bladder cancer 认领 引用
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作者 Arjun Pon Avudaiappan Pushan Prabhakar +4 位作者 Hannah Baker Mukesh K.Roy Manuel Ozambela Jr Christopher Gomez Murugesan Manoharan 《The Canadian Journal of Urology》 SCIE 2025年第3期137-143,共7页
Introduction:Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma(MIBC);however,there is a growing interest in bladder preservation alternatives among the e... Introduction:Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma(MIBC);however,there is a growing interest in bladder preservation alternatives among the elderly population.Guidelines indicate that partial cystectomy(PC)combined with pelvic node dissection(LND)can be considered as an alternative in carefully selected individuals.Using the National Cancer Database,we analyzed the overall survival(OS)between PC with and without LND among octogenarians.Methods:We identified octogenarians with localized muscle-invasive bladder carcinoma(cT2-3N0M0)and urothelial histology who underwent PC with or without LND between 2004 and 2018.Based on the number of lymph nodes removed(LNR),the LND group was further subdivided into=10 lymph node groups.A propensity-matched Kaplan-Meier survival analysis was performed to compare OS between these groups.Results:Among 2573 patients who underwent PC,492 octogenarians met our selection criteria.208(42.2%)had LND,while 284(57.8%)had no LND.Within the LND group,53(25.5%)had=10 LNR.The median OS for the matched LND and non-LND groups was 36.9 and 33.4 months(p=0.96),respectively.Similarly,=10 LNR had 36.9 and 43.5 months(p=0.42),respectively.Multivariate Cox regression analysis revealed no difference in the risk of mortality.Conclusion:Among octogenarians who underwent PC,there was no significant difference in OS between those with or without LND,and between=10 LNR groups.Therefore,the role and extent of LND after PC need further exploration in this subset of the population. 展开更多
关键词 partial cystectomy pelvic node dissection muscle-invasive bladder cancer elderly octogenarian
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Clinical outcomes of radiofrequency catheter ablation of atrial fibrillation in octogenarians lO-year experience of a one high-volume center 认领 引用 被引量：6
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作者 Alan Bulava Jiri Hanis Ladislav Dusek 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第9期575-581,共7页
Background Prevalence of atrial fibrillation （AF） increases with age. Radiofrequency catheter ablation （RFCA） is an establishedtreatment option superior to antiarrhythmics （AAs）. In this study, we investigated s... Background Prevalence of atrial fibrillation （AF） increases with age. Radiofrequency catheter ablation （RFCA） is an establishedtreatment option superior to antiarrhythmics （AAs）. In this study, we investigated safety and efficacy of RFCA of AF in octogenarians.Methods From our database, we extracted procedural and follow-up data for patients 〉 80 years with symptomatic AF undergoing RFCAand compared this population to RFCA patients 〈 50 years. All patients underwent pulmonary vein isolation （PVI） supplemented by linearlesions in PVI-nonresponders. Arrhythmia-free survival was assessed using seven day Holter every three months post procedure. All patientscompleted their 12 months follow-up. Results Fifty patients aged ≥80 years （80.5 ± 1.6 years） were compared to 259 patients aged 〈 50years （43.5±5.5 years）. The RFCA complication rate did not vary between groups. No differences in procedural characteristics were seenafter being analyzed by type of AF. Among patients with paroxysmal AF, 71.4% octogenarian vs. 84.7% young patients was free of anyarrhythmia, without AAs, after single procedure. For non-paroxysmal AF, arrhythmia-free survival without AAs, was considerably lower（58.6% octogenarians vs. 81.2% younger patients, P = 0.023）. If AAs were used, arrhythmia-free survival for paroxysmal AF increased to90.5% and 92.1% in octogenarians and younger patients, respectively; and in non-paroxysmal AF it increased to 79.3% vs. 88.4%. ConclusionsRFCA is a safe and effective strategy to achieve normal sinus rhythm in a highly selected group of octogenarians. Paroxysmal AF ablation inoctogenarians has similar clinical effectiveness as that seen in much younger patients. Non-paroxysmal AF ablation has lower, but still rea-sonable clinical effectiveness. 展开更多
关键词 Atrial fibrillation Catheter ablation Effectiveness Octogenarians Safety The elderly
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Intermediate-term mortality and incidence of ICD therapy in octogenarians after cardiac resynchronization therapy 认领 引用 被引量：2
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作者 Heval Mohamed Kelli Faisal MMerchant +3 位作者 Andenet Mengistu Mary Casey Michael Hoskins Mikhael FEl-Chami 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2014年第3期180-184,共5页
Background Clinical outcomes of cardiac resynchronization therapy （CRT） in patients over the age of 80 have not been well de-scribed.MethodsWe retrospectively identified 96 consecutive patients≥ 80 years old who un... Background Clinical outcomes of cardiac resynchronization therapy （CRT） in patients over the age of 80 have not been well de-scribed.MethodsWe retrospectively identified 96 consecutive patients≥ 80 years old who underwent an initial implant or an upgrade to CRT, with or without defibrillator （CRT-Dvs. CRT-P）, at our institution between January 2003 and July 2008. The control cohort consisted of 177 randomly selected patients 〈 80 years old undergoing CRT implant during the same time period. The primary efficacy endpoint was all-cause mortality at 36 months, assessed by Kaplan-Meier time to first event curves.Results In the octogenarian cohort, mean age at CRT implant was 83.1 ± 2.9 yearsvs. 60.1 ± 8.8 years among controls （P 〈 0.001）. Across both groups, 70% were male, mean left ventricular ejection fraction （LVEF） was 24.8% ± 14.1% and QRS duration was 154 ± 24.8 ms, without significant differences between groups. Octo-genarians were more likely to have ischemic cardiomyopathy （74%vs. 37%,P 〈 0.001） and more likely to undergo upgrade to CRT instead of an initial implant （42%vs. 19%,P 〈 0.001）. The rate of appropriate defibrillator shocks was lower among octogenarians （14%vs. 27%,P = 0.02） whereas the rate of inappropriate shocks was similar （3%vs. 6%,P = 0.55）. At 36 months, there was no significant difference in the rate of all-cause mortality between octogenarians （11%） and controls （8%,P = 0.381）.ConclusionAppropriately selected octogenarians who are candidates for CRT have similar intermediate-term mortality compared to younger patients receiving CRT. 展开更多
关键词 Octogenarians Cardiac resynchronization therapy Implantable cardioverter-defibrillator
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Coronary artery bypass grafting in the octogenarians:should we intervene,or leave them be? 认领 引用 被引量：5
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作者 Anil Ozen Ertekin Utku Unal +7 位作者 Murat Songur Sinan Sabit Kocabeyoglu Onur Hanedan Metin Yilmaz Basak Soran Turkcan Ferit Cicckcioglu Sadi Kaplan Cemal Levent Birincioglu 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第2期147-152,共6页
Objective Coronary artery bypass grafting(CABG)is gradually increasing in the elderly population.We aimed to investigate the risk factors and the results of CABG along with the long term survival in patients at an age... Objective Coronary artery bypass grafting(CABG)is gradually increasing in the elderly population.We aimed to investigate the risk factors and the results of CABG along with the long term survival in patients at an age of 80 and older.Methods Between Januaa-y 2002 and December 201 I,a total of i01 consecutive patients at an age of S0 and older who underwent CABG in our hospital were included in the study.The patients were followed and the long-term survival was estimated.Results The mean age of the patients was 82.98~2.27 years.Sixty-four(63.4%)were males and 37(36.6%)were females.Emergency surgery,duration of cardiopulmonary bypass,the intensive care unit(ICU)stay,inotropic support,intra aortic balloon pulsation application,amount oferythrocyte transfusion and flesh frozen plasma transfusion and ventilation period were significantly higher in the patients who died in the hospital.The duration of cardiopulmonary bypass(CPB)was found to be an inde-pendent predictor of mortality(OR:1.18,95%CI 1.01-1.38,P=0.034).The in-hospital mortality was 16.8%.Kaplan-Meier analyses revealed a survival ratio of 91.3%at one year,82.9%at three years and 69.0%at five years.Conclusions Patients at the age of 80 and older can be candidates for the CABG procedure bearing in mind that they may have a longer ventilation period and intensive care unit stay.The morbidity and mortality of this age group is considered within an acceptable range.Approaches to minimize CPB,or the choice of off-pump surgery,may be a preventive method to lower the incidence of mortality.Hence,CABG may be performed in this age group with a satisfactory survival ratio. 展开更多
关键词 Cardiopulmonary bypass Complications Coronary artery bypass Mortality Octogenarians
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Percutaneous nephrolithotomy in octogenarians and beyond:How old is too old? 认领 引用 被引量：1
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作者 Bradley Morganstern Riccardo Galli +6 位作者 Piruz Motamedinia David Leavitt Mohamed Keheila Eric Ghiraldi David Hoenig Arthur Smith Zeph Okeke 《Asian Journal of Urology》 2015年第4期208-213,共6页
Objective:To specifically report perioperative characteristics and outcomes in patients 80 years and older undergoing percutaneous nephrolithotomy(PCNL).PCNL has been established as feasible in the elderly;however,to ... Objective:To specifically report perioperative characteristics and outcomes in patients 80 years and older undergoing percutaneous nephrolithotomy(PCNL).PCNL has been established as feasible in the elderly;however,to our knowledge no one has specifically reported feasibility in patients 80 years and older.Methods:We retrospectively reviewed perioperative data of octogenarians who underwent PCNL at a high stone volume single institution,and matched them to patients<65 years of age by stone burden and sex.Patient demographics,perioperative outcomes and postoperative complications were compared.Results:Thirty-three octogenarians(mean age 83.6 years)with 36 renal units were matched to 67 controls(mean age 48.6 years)with 72 renal units.Octogenarians had a higher mean American Society of Anesthesiologists(ASA)score,more comorbidities,and worse renal function.There were no differences in operative characteristics,length of hospital stay or stone free rates.Of the patients with preoperative urinary decompression(ureteral stent or nephrostomy tube)prior to PCNL,the elderly were more likely to have a history of urosepsis.Octogenarians did not experience more minor Clavien(Ⅰ-Ⅱ)or major Clavien(Ⅲa-Ⅳb)complications.Conclusion:Octogenarians who undergo PCNL were more likely to have cardiovascular comorbidities and a prior history of sepsis.Despite these risk factors,in appropriately selected patients PCNL can be safely and successfully performed in octogenarians without increased perioperative complications relative to a younger cohort. 展开更多
关键词 Percutaneous nephrolithotomy Elderly Percutaneous stone extraction complications Clavien Octogenarians Percutaneous stone extraction
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Improvements in quality of life in septuagenarians versus octogenarians undergoing trans-catheter aortic valve replacement 认领 引用
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作者 Nuray Kahraman Ay Yasin Ay +2 位作者 Osman Sonmez Mehmet Akif Vatankulu Omer Goktekin 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第5期439-443,共5页
Background Very elderly patients represent a distinct patient group in clinical setting in terms of a decision for trans-catheter aortic valve replacement （TAVR） when one considers the potential improvement in the q... Background Very elderly patients represent a distinct patient group in clinical setting in terms of a decision for trans-catheter aortic valve replacement （TAVR） when one considers the potential improvement in the quality of life （QoL） on one hand and the benefit to risk ratio on the other. This study aimed to compare functional and QoL outcomes of TAVR between octogenarians and septuagenarians. Methods This prospective cohort study included 136 elderly patients （70 to 89 years of age）, who tmderwent Wansfemoral TAVR due to degenerative aortic stenosis. Patients were allocated into one of the following age groups： septuagenarians （n = 67） and octogenarians （n = 69）. Preoperative and early postoperative clinical parameteT：s were recorded. In addition, QoL of the patients was evaluated using SF-36 questionnaire preoperatively and six month postoperatively. Results Groups were similar in terms of early postoperative mortality and morbidity parameters. The mean New York Heart Association （NYHA） class improved after TAVR in both groups. In addition, all SF-36 norm-based scale and SF-36 summary scale scores improved significantly in both groups during the postoperative period. Postoperatively, physical functioning, general health and physical component summary scores were significantly better in the septuagenarian group （P = 0.02, 0.01, 0.03, respectively）. ConcLusion Although the improvement in the QoL in terms of physical health was more marked in septuagenarians than in octogenarians, substantial benefits on the QoL and particularly on mental health seem to justify re-consideration of TAVR indications in the very elderly. 展开更多
关键词 Elderly Octogenarians Quality of life Septuagenarian Trans-catheter aortic valve replacement
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Steerable microcatheters for complex percutaneous coronary interventions in octogenarians: from Venture to Swift Ninja 认领 引用
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作者 George Kassimis Nestoras Kontogiannis Tushar Raina 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2019年第1期54-59,共6页
0ctogenarians represent the fastest growing group of patients undergoing percutaneous coronary intervention(PCI),now constituting more than one in five patients treated with PCI in real-world practice.[1,2]Comparing c... 0ctogenarians represent the fastest growing group of patients undergoing percutaneous coronary intervention(PCI),now constituting more than one in five patients treated with PCI in real-world practice.[1,2]Comparing coronary lesion characteristics of patients aged<≥80 years to those≥80 years undergoing PCI,the octogenarians have a higher prevalence of calcified and ostial lesions,tortuous coronary anatomy,multi-vessel disease and left main stem(LMS)stenosis.⑶Furthermore,they often have greater ischemic burden than their younger counterparts,suggesting an even greater benefit following revascularization. 展开更多
关键词 Acute angle branch Octogenarians Steerable microcatheters Supercross Swift Ninja Venture wire control catheter
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Cardiac Surgery in Octogenarians and Beyond: Single Center Experience 认领 引用
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作者 Reda E. Al-Refaie Hashem Aliter +3 位作者 Ricardo Gallo Ali Youssef Mushabab Al-Murayeh Edwin Ravikumar 《Open Journal of Thoracic Surgery》 2013年第2期51-56,共6页
Background: Increasing numbers of octogenarians and improvements in surgical techniques and postoperative care have resulted in increasing cardiac operations in this age. The aim is to analyze our experience of cardia... Background: Increasing numbers of octogenarians and improvements in surgical techniques and postoperative care have resulted in increasing cardiac operations in this age. The aim is to analyze our experience of cardiac surgery on octogenarians and beyond concerning postoperative morbidities and mortality. Methods: 67 octogenarians and nonagenarians underwent open heart surgery in our hospital between 2001 to 2009 were retrospectively reviewed. Data included baseline preoperative status, intraoperative and perioperative course, and immediate outcomes. Results: The mean age was 86.22 ± 6.1 years. 86.6% patients were males. Symptoms were dyspnea;Class II in 13.4%, Class III in 55.2%, Class IV in 31.4% patients;angina in 82.1%, and CHF in 25.4% patients. The mean EF was 37.8% ± 10. Risk factors include smoking in 52.2%, DM in 37.3%, hypertension in 28.4%, obesity in 25.4%, previous MI in 22.4%, COPD in 17.9%, renal insufficiency in 11.9%, pulmonary hypertension in 7.5%, PVD in 6%, and cerebrovascular disease in 3% patients. The procedures were isolated CABG in 73%, AVR in 9%, MVR in 6%, CABG/valve in 9%, and MVR and AVR in 3% patients. Complications were 18%. It included renal impairment in 18%, arrhythmias in 14.9%, bleeding in 6%, prolonged ventilation in 13.4%, CHF in 4.5%, gastrointestinal bleeding in 4.5%, wound infection in 7.5%, and cerebrovascular accident in 3%. Hospital mortality was 9% patients. Conclusions: Cardiac surgery can be performed safely with acceptable hospital morbidity and mortality in octogenarians and beyond. Early referral and proper selection of patients are mandatory to improve immediate postoperative survival. 展开更多
关键词 Coronary Artery Bypass Graft Valve Octogenarians Nonagenarian
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Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis 认领 引用 被引量：2
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作者 Rajkumar Doshi Vaibhav Patel Priyank Shah 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第2期123-130,共8页
Background Aortic valve stenosis （AS） is very common in the elderly patients above 80 years. Transcatheter aortic valve replacement （TAVR） in such patients is being increasingly performed. This study sought to ass... Background Aortic valve stenosis （AS） is very common in the elderly patients above 80 years. Transcatheter aortic valve replacement （TAVR） in such patients is being increasingly performed. This study sought to assess in-hospital outcome differences between octogenarians and nonagenarians and predictors of mortality in nonagenarians undergoing TAVR with severe AS. Method The study population was derived from the National Inpatient Sample （MS） for the years 2012-2014 using ICD-9 CM procedure codes 35.05 and 35.06 for TAVR. Hospitalizations below 80 years of age were excluded. After performing propensity score matching （1： 2）, in-hospital outcomes were compared in matched cohorts. Then, multivariate model was developed to analyze predictors of in-hospital mortality in nonagenarians. Results There were 11,630 hospitalizations in the octogenarian and 5815 hospitalizations in the nonagenarian group. Primary outcome of in-hospital mortality （6% vs. 4.1%, P ≤ 0.001） was higher in nonagenarians compared to octogenarians. Secondary outcomes including stroke （3.4% vs. 2.8%, P ≤ 0.001）, renal failure （18.9% vs. 17.3%, P ≤0.001）, blood transfusion （35% vs. 32.6%, P ≤ 0.001）, vascular complications （4.5% vs. 3.5%, P ≤ 0.001）, and pacemaker implantation （27.8% vs. 24.8%, P ≤ 0.001） were higher in nonagenarians. There was no difference in their length of stay. Median cost （70,3745 vs. 65,3815, P ≤ 0.001） was slightly higher with nonagenarian. Conclusions Although in-hospital mortality is slightly higher in nonagenarians, it is acceptable. This difference in mortality is at least partly explained by higher complications in nonagenarians. Efforts should be made to decrease the complications which can further narrow the difference in in-hospital mortality between the groups. 展开更多
关键词 Nonagenarian Octogenarian Quality of Life Transcatheter aortic valve replacement
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Outcomes of elective laparoscopic colorectal operations in octogenarians at a district general hospital in South East England 认领 引用 被引量：1
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作者 Roland Fernandes Irshad Shaikh Samer Doughan 《World Journal of Gastrointestinal Surgery》 2013年第1期9-11,共3页
AIM:To assess the outcomes of laparoscopic colorectal cancer resection in the octogenarian population at our institution.METHODS:Retrospective analysis of registry data accumulated prospectively were used in conjuncti... AIM:To assess the outcomes of laparoscopic colorectal cancer resection in the octogenarian population at our institution.METHODS:Retrospective analysis of registry data accumulated prospectively were used in conjunction with the data obtained from patient notes to identify outcome data for octogenarians who had undergone elective laparoscopic colorectal cancer resection.RESULTS:Laparoscopic colorectal cancer resections were performed in 68 octogenarians between 2003 and 2011 at our institution.Four operations(6%) were converted to an open technique.There were twelve cases of morbidity(18%) and two cases of mortality(3%).The overall median hospital stay was 8 d.The median time for a patient to be deemed surgically fit for discharge was 5 d reflecting a delay in provision of social care or stoma education.CONCLUSION:Our results support the view that laparoscopic surgery in octogenarians is safe,feasible and with a reduced length of stay.This is well reflected in our results which are compatible with United Kingdom national figures. 展开更多
关键词 Laparoscopic surgery Colorectal disease Octogenarian Mortality Morbidity
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Evaluation of long stent implantation in diffuse coronary lesions for octogenarians 认领 引用
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作者 Osamu Katoh Shigeru Nakamura 《Journal of Geriatric Cardiology》 CAS 2005年第1期29-35,共7页
Objective To evaluate angiographic and clinical outcomes of ≥ 20mm long stents or overlapped stent implantation in diffuse coronary lesions for octogenarians, in comparison with patients under sixty. Methods Two grou... Objective To evaluate angiographic and clinical outcomes of ≥ 20mm long stents or overlapped stent implantation in diffuse coronary lesions for octogenarians, in comparison with patients under sixty. Methods Two groups (Group O: 47 lesions in 44 octogenarians, aged 81± 3 years; Group Y: 64 lesions in 58 patients under sixty, aged 54 ± 4 years) were compared with a 6-month follow-up. Results Success rate of the procedures was 100%. None had in-hospital major adverse cardiac events (MACE). There was no significant difference in angiographic restenosis between the groups at follow-up (Group O vs Group Y, 29.8 % vs 26.6 %, P = NS). The revascularization of target vessel and MACE was less in Group Y, but these showed no statistical significance (15.6% vs 23.4% and 20.7% vs 25.0%, respectively). Conclusions Long stent implantation for diffuse coronary lesions in octogenarians appears safe and feasible, with high procedural success and favorable long-term outcomes. 展开更多
关键词 percutaneous coronary intervention octogenarian diffuse lesion coronary stenting follow-up
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When not to reintervene:three-dimensional echocardiography guiding conservative management in frail octogenarian with post-TEER tricuspid regurgitation 认领 引用
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作者 Elpidio Santillo Michela Maria Nazarena Coco +2 位作者 Anna Libertazzi Cinzia Giuli Monica Migale 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第5期326-329,共4页
The management of severe tricuspid regurgitation(TR)in elderly patients has been transformed by transcatheter edge-to-edge repair(TEER),now a cornerstone for those at prohibitive surgical risk.[1]However,with increasi... The management of severe tricuspid regurgitation(TR)in elderly patients has been transformed by transcatheter edge-to-edge repair(TEER),now a cornerstone for those at prohibitive surgical risk.[1]However,with increasing procedural volumes,recurrent TR after TEER is emerging as a relevant clinical challenge.[2]Although three-dimensional(3D)echocardiography provides superior characterization of complex post-procedural orifices,its role in guiding the difficult decision between redo intervention and conservative management in octogenarians remains insufficiently defined.[3,4] 展开更多
关键词 post TEE tricuspid regurgitation three dimensional echocardiography conservative management redo intervention tricuspid regurgitation tr recurrent tricuspid regurgitation frail octogenarian transcatheter edge edge repair
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Survival after resection of colorectal liver metastases in octogenarians and sexagenarians compared to their respective age-matched national population 认领 引用
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作者 Kristoffer Watten Brudvik Bard Rosok +5 位作者 Usha Naresh Sheraz Yaqub Asmund Avdem Fretland Knut Jorgen Labori Bjorn Edwin Bjorn Atle Bjornbeth 《Hepatobiliary Surgery and Nutrition》 SCIE 2018年第4期234-241,共8页
Background:The aim of the current study was to investigate survival after resection of colorectal liver metastases(CLM)in octogenarians.The survival of octogenarian patients was compared to the survival of the nationa... Background:The aim of the current study was to investigate survival after resection of colorectal liver metastases(CLM)in octogenarians.The survival of octogenarian patients was compared to the survival of the national population of octogenarians and the survival of sexagenarians,the latter representing the average-age patient undergoing resection of CLM.Methods:Octogenarian and sexagenarian were defined as person 80–89 and 60–69 years of age,respectively.Survival analyses of patients who underwent resection of CLM between 2002 and 2014 were performed.Data from Statistics Norway were used to estimate the survival of the age-matched national population of octogenarians(ageM-Octo)and the age-matched national population of sexagenarians(ageM-Sexa).Results:During the study period,59 octogenarians underwent resection of CLM.The majority of patients underwent a minor liver resection(n=50).In octogenarians,the 5-year survival was 32.5%and 66.3%[difference,33.8 percentage points(pp)]in patients and ageM-Octo,respectively.The 10-year survival was 14.1%and 31.2%(difference,17.1 pp)in patients and ageM-Octo,respectively.In sexagenarians,the 5-year survival was 50.9%and 96.2%(difference,45.3 pp)in patients and ageM-Sexa,respectively.The 10-year survival was 35.7%and 90.3%(difference,54.6 pp)in patients and ageM-Sexa,respectively.The 5-year cancer-specific survival and 5-year recurrence-free survival(RFS)after resection of CLM in octogenarians were 43.1%and 32.9%,respectively.Conclusions:After resection of CLM,the survival was poorer in octogenarians than in sexagenarians.However,the difference between the survival curves of patients and their age-matched population was smaller in octogenarians.In practice,this finding may indicate a greater benefit of resection in the elderly than the survival rates alone would suggest. 展开更多
关键词 Liver resection elderly octogenarians colorectal liver metastases(CLM) survival
Microwave ablation of hepatocellular carcinomas in octogenarians 认领 引用
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作者 Jacob Freedman 《Hepatoma Research》 CAS 2020年第3期24-30,共7页
Aim:To evaluate wether it is safe and meaningful to treat octogenarians with microwave ablation for hepatocellular carcinoma.With an ageing population being healthier than previous generations,old limits for treating ... Aim:To evaluate wether it is safe and meaningful to treat octogenarians with microwave ablation for hepatocellular carcinoma.With an ageing population being healthier than previous generations,old limits for treating disease founded on patient age need to be revised.One of the most common tumour related death causes is hepatocellular carcinoma(HCC).With the development of minimally invasive therapies with curative potential,new ground is being broken offering treatments to older patients in the hope of achieving prolongation and better quality of life.Methods:In this retrospective single centre study of patients having a first microwave ablation therapy for HCC in a national referral centre for ablative liver treatments,septuagenarians(n=161,age 70-80)were compared with octogenarians(n=32,age 80-90).Results:Octogenarians selected for microwave ablation of HCC at a regional multidisciplinary team conference have similar outcomes as their younger control group.Survival,complications and length of stay are not different.Conclusion:Octogenarians who are fit for ablative treatment of HCC should not be disqualified on grounds of age,recognising that this group has an obvious immortality,or lead-time,bias as well as a probable selection bias in part explaining their good results. 展开更多
关键词 Microwave ablation hepatocellular carcinoma octogenarians survival complications
Clinical efficacy of different treatments and their impacts on the quality of life of octogenarians with coronary artery disease 认领 引用 被引量：4
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作者 Xiang-Yu Wu Tao Ying +5 位作者 Cheng-Qian Yin Su Wang Yu-Long Gao Yu-Tong Cheng Zhao Li Zhi-Zhong Li 《Chinese Medical Journal》 SCIE CAS CSCD 2019年第22期2657-2663,共7页
Background:Coronary artery disease(CAD)in octogenarians(age of>80 years)has a high risk of mortality and high expenses.Research shows that the prevalence of CAD is higher among octogenarians than that among younger... Background:Coronary artery disease(CAD)in octogenarians(age of>80 years)has a high risk of mortality and high expenses.Research shows that the prevalence of CAD is higher among octogenarians than that among younger people,but few such patients undergo percutaneous coronary intervention(PCI)or coronary artery bypass grafting(CABG).This study aimed to evaluate different treatments w让h respect to their clinical effects and impacts on quality of life of octogenarians with CAD.Methods:Data of 519 octogenarians with CAD consecutively treated at Beijing Anzhen Hospital,Capital Medical University(Beijing,China)from January 2010 to January 2016 were collected in this study.The patients were categorized into three groups based on the treatments they received:the PCI group(n=292),CABG group(n=110),and medical treatment group(n=117).The followings were recorded during follow-up:clinical data,death(all-cause and cardiovascular-related),re-hospitalization time,Seattle Angina Questionnaire(SAQ)score,and occurrence of hemorrhagic events(cerebral bleeding,gastrointestinal bleeding,and dermal ecchymosis).Results:The median follow-up duration was 25.0(25th,75th percentile:17.0,55.5)months among 417 patients.The all-cause death rates(28.2%vs.12.0%and 14.6%,respectively)and cardiovascular-related death rates(15.4%us.3.8%and 6.4%,respectively)were significantly higher in the medical treatment group than those in the PCI group and CABG group(all P<0.05).The re-hospitalization rate for cardiovascular events was significantly lower in the CABG group than those in the PCI group and medical treatment group(3.8%vs.12.8%and 14.9%,respectively)(x^2=8.23&P=0.018).The SAQ scores of physical limitation,angina frequency,treatment satisfaction,and disease perception were significantly higher in the PCI group and CABG group than those in the medical treatment group(all P<0.05).No significant difference in the angina stability score was observed among the three groups(F=3.179,P=0.204).Conclusion:PCI and CABG result in reduced mortality and better quality of life in octogenarians with CAD. 展开更多
关键词 Coronary artery disease Octogenarian Percutaneous coronary intervention Coronary artery bypass graft Death Life quality
Random forests to predict survival of octogenarians with brain metastases from nonsmall-cell lung cancer 认领 引用
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作者 Lijun Song Yu Wang +5 位作者 Xue Li Yi Liu Bingyi Yin Daorui Li Hongsheng Lin Yuqi Zhang 《Brain Science Advances》 2024年第1期39-56,共18页
Background:To create and validate nomograms for the personalized prediction of survival in octogenarians with newly diagnosed nonsmall-cell lung cancer(NSCLC)with sole brain metastases(BMs).Methods:Random forests(RF)w... Background:To create and validate nomograms for the personalized prediction of survival in octogenarians with newly diagnosed nonsmall-cell lung cancer(NSCLC)with sole brain metastases(BMs).Methods:Random forests(RF)were applied to identify independent prognostic factors for building nomogram models.The predictive accuracy of the model was evaluated based on the receiver operating characteristic(ROC)curve,C-index,and calibration plots.Results:The area under the curve(AUC)values for overall survival at 6,12,and 18 months in the validation cohort were 0.837,0.867,and 0.849,respectively;the AUC values for cancer-specific survival prediction were 0.819,0.835,and 0.818,respectively.The calibration curves visualized the accuracy of the model.Conclusion:The new nomograms have good predictive power for survival among octogenarians with sole BMs related to NSCLC. 展开更多
关键词 octogenarian NSCLC brain metastases random forests nomogram
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An overview of PCI in the very elderly 认领 引用 被引量：26
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作者 Vimalraj Bogana Shanmugam Richard Harper +2 位作者 Ian Meredith Yuvaraj Malaiapan Peter J Psaltis 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第2期174-184,共11页
Cardiovascular disease,and in particular ischemic heart disease(IHD),is a major cause of morbidity and mortality in the very elderly(〉80 years)worldwide.These patients represent a rapidly growing cohort presenting fo... Cardiovascular disease,and in particular ischemic heart disease(IHD),is a major cause of morbidity and mortality in the very elderly(〉80 years)worldwide.These patients represent a rapidly growing cohort presenting for percntaneous coronary intervention(PCI),now constituting more than one in five patients treated with PCI in real-world practice.Furthermore,they often have greater ischemic burden than their younger counterparts,suggesting that they have greater scope of benefit from coronary revascularization therapy.Despite this,the very elderly are frequently under-represented in clinical revascularization trials and historically there has been a degree of physician reluctance in referring them for PCI procedures,with perceptions of disappointing outcomes,low success and high complication rates.Several issues have contributed to this,including the tendency for older patients with IHD to present late,with atypical symptoms or non-diagnostic ECGs,and reservations regarding their procedural risk-to-benefit ratio,due to shorter life expectancy,presence of comorbidities and increased bleeding risk from antiplatelet and anticoagulation medications.However,advances in PCI technology and techniques over the past decade have led to better outcomes and lower risk of complications and the existing body of evidence now indicates that the very elderly actually derive more relative benefit from PCI than younger populations.Importantly,this applies to all PCI settings:elective,urgent and emergency.This review discusses the role of PCI in the very elderly presenting with chronic stable IHD,non ST-elevation acute coronary syndrome,and ST-elevation myocardial infarction.It also addresses the clinical challenges met when considering PCI in this cohort and the ongoing need for research and development to further improve outcomes in these challenging patients. 展开更多
关键词 Acute coronary syndrome Angina Antithrombotic therapy Myocardial infarction Octogenarians Percutaneous coronary intervention The elderly
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Acute upper gastrointestinal bleeding in octοgenarians:Clinical outcome and factors related to mortality 认领 引用 被引量：15
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作者 George J Theocharis Vassiliki Arvaniti +4 位作者 Stelios F Assimakopoulos Konstantinos C Thomopoulos Vassilis Xourgias Irini Mylonakou Vassiliki N Nikolopoulou 《World Journal of Gastroenterology》 SCIE CAS 2008年第25期4047-4053,共7页
AIM: To evaluate the aetiology, clinical outcome and factors related to mortality of acute upper gastrointestinal bleeding (AUGIB) in octogenarians. METHODS: We reviewed the records of all patients over 65 years old w... AIM: To evaluate the aetiology, clinical outcome and factors related to mortality of acute upper gastrointestinal bleeding (AUGIB) in octogenarians. METHODS: We reviewed the records of all patients over 65 years old who were hospitalised with AUGIB in two hospitals from January 2006 to December of 2006. Patients were divided into two groups: Group A (65-80 years old) and Group B (> 80 years old). RESULTS: Four hundred and sixteen patients over 65 years of age were hospitalized because of AUGIB. Group A included 269 patients and Group B 147 patients. Co-morbidity was more common in octogenarians (P = 0.04). The main cause of bleeding was peptic ulcer in both groups. Rebleeding and emergency surgery were uncommon in octogenarians and not different from those in younger patients. In-hospital complications were more common in octogenarians (P = 0.05) and more patients died in the group of octogenarians compared to the younger age group (P = 0.02). Inability to perform endoscopic examination (P = 0.002), presence of high risk for rebleeding stigmata (P = 0.004), urea on admission (P = 0.036), rebleeding (P = 0.004) and presenceof severe co-morbidity (P < 0.0001) were related to mortality. In multivariate analysis, only the presence of severe co-morbidity was independently related to mortality (P = 0.032). CONCLUSION: While rebleeding and emergency surgery rates are relatively low in octogenarians with AUGIB, the presence of severe co-morbidity is the main factor of adverse outcome. 展开更多
关键词 Acute upper gastrointestinal bleeding Octogenarians Elderly Co-morbidity Mortality
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