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Cloning and analysing of 5'flanking region of Xenopus organizer gene noggin 认领 引用
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作者 TAO QIN HUA JING YANG +2 位作者 WEN YAN MEI XlN GENG XIAO YAN DING 《Cell Research》 SCIE CAS 1999年第3期209-216,共8页
Xenopus organizer specific gene Noggin possessesnearly all the characterestic properties of the action of or-ganizer to specify the embryonic body axis.To analyzehow the maternal inherited factors cofltrol its express... Xenopus organizer specific gene Noggin possessesnearly all the characterestic properties of the action of or-ganizer to specify the embryonic body axis.To analyzehow the maternal inherited factors cofltrol its expressionpattern,we cloned the 5’regulatory region of noggn gene.The 1.5 kb upstream sequense could direct reporter geneto express in vivo and data from deletion analysis indi-cated that a 229 base pair fragmet is essential for acti-vating noggn expression.We further demonstrated thatthe response elements within this regulatory region wereindeed under the control of growth factor activin and Wntsignaling pathway components. 展开更多
关键词 Xenopus organizer specific gene noggin regulatory region
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NUCLEOLAR ORGANIZER REGIONS IN CUTANEOUS T CELL LYMPHOMAS 认领 引用
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作者 许良中 陈红莉 +1 位作者 邱丙森 陶玲娣 《Chinese Journal of Cancer Research》 CAS 1990年第3期61-64,共4页
The present work studied the application of AgNOR count to differential diagnosis between cutaneous T cell lymphoma (CTCL) and cutaneous pseudolymphoma (CPL). Paraffin sections from 50 mycosis fungoides (22 MFI-Premyc... The present work studied the application of AgNOR count to differential diagnosis between cutaneous T cell lymphoma (CTCL) and cutaneous pseudolymphoma (CPL). Paraffin sections from 50 mycosis fungoides (22 MFI-Premycotic stage, 24 MF Ⅰ infiltrative stage and 4 MF Ⅲ - tumor stage), 2 nonepidermotropic cutaneous T cell lymphoma (NECTCL) and 9 CPL were investigated. In each case, 200 cells randomly selected were examined using a × 100 oil immersion lens. The mean number, standard deviation and standard error of the mean of AgNOR counts were as follows: MFⅠ 1.17±0.09, SEM = 0.01; MⅡ 1.17±0.01, SEM = 0.01; MF Ⅲ. 3.55±0.87, SEM = 0.43; NECTCL 4.5±0.28, SEM -0.199; CPL 1.17±0.1, SEM ± 0.03. The results revealed a highly significant difference between CTCL (MFⅢ+NECTCL) and CPL (t = 4.75, P<0.001), tumor stage (MF Ⅲ) and pretumor stage (MFI, MF Ⅱ) of mycosis fungoides (t = 4.75, P<0.001). Thus. AgNOR count is valuable in differential diagnosis. 展开更多
关键词 AgNORs MFI NUCLEOLAR ORGANIZER REGIONS IN CUTANEOUS T CELL LYMPHOMAS
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STUDIES OF NUCLEOLAR ORGANIZER REGIONS AND MUCIN HISTOCHEMISTRY IN ULCERATIVE COLITIS 认领 引用
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作者 虞积耀 杜毅 +4 位作者 夏敏良 胡端民 王鲁平 邢惠清 田玉旺 《Chinese Journal of Cancer Research》 CAS 1992年第2期46-50,共5页
The argyrophil method for nucleolar organizer regions (AgNOR) known as the AgNor technique and mucin histochemical stain were applied to Investigate the dysplasia and cancaration in ulcerative colitis Including 58 cas... The argyrophil method for nucleolar organizer regions (AgNOR) known as the AgNor technique and mucin histochemical stain were applied to Investigate the dysplasia and cancaration in ulcerative colitis Including 58 cases of biopsy specimens and three cases operative specimens. The numbers of AgNOR have been gradully increased with the grades of dasplasls. Similarly the percentage of sialomucin having vicinal diols on side chain of sialic acid also gradully Increased with the grades of dysplasia. The AgNOR reflects rDNA transcriptional activity responsible for degrees of differentiation of cell. Epithelial cells secreting a heterogeneous mucin, could be taken as a signal of abnormal cellular differentiation. AgNOR and mucln chages might be assumed as a criteria In representing malignant transformation. 展开更多
关键词 AgNOR STUDIES OF NUCLEOLAR ORGANIZER REGIONS AND MUCIN HISTOCHEMISTRY IN ULCERATIVE COLITIS
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Making DDL Engaging Through Advance Organizers and Prediction Activities 认领 引用
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作者 金忍冬 《海外英语》 2012年第18期72-73,86,共2页
This paper addresses some of the requirements of the advance organizers and prediction activities for DDL(Data-Driv en Learning) based on multi-modal corpora for learning English as a second language.It analyzes preli... This paper addresses some of the requirements of the advance organizers and prediction activities for DDL(Data-Driv en Learning) based on multi-modal corpora for learning English as a second language.It analyzes preliminary advantages and dis advantages of using multi-modal corpora for DDL and focuses on key methodological issues related to self-guided learning and corpus operation.Pedagogical suggestions are provided on how to make the multi-modal corpora based DDL engaging in accor dance with Krashen' s Language Input Hypothesis with the assistance of advance organizers and prediction activities. 展开更多
关键词 DDL advance organizers prediction activities
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Argyrophilic nucleolar organizer region in MIB-1 positive cells in non-small cell lung cancer: clinicopathological significance and survival 认领 引用
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作者 Dmitriy Sergeevich Kobyakov Ashot Merudzhanovich Avdalyan +2 位作者 Aleksandr Fedorovich Lazarev Elena Leonidovna Lushnikova Lev Moiseevich Nepomnyashchikh 《Cancer Biology & Medicine》 CAS CSCD 2014年第4期264-269,共6页
Objective： To evaluate the relation between argyrophilic nucleolar organizer region （AgNOR）-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer （NSCLC）. Methods： A t... Objective： To evaluate the relation between argyrophilic nucleolar organizer region （AgNOR）-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer （NSCLC）. Methods： A total of 207 surgical specimens diagnosed as NSCLC were included in this study. Double-staining procedures were performed using antigen Ki-67 （clone MIB-1） and silver nitrate by immunohistochemical and AgNOR-staining methods. Results： The AgNOR area in MIB-l-positive cells of NSCLC is related to clinicopathological parameters under the TNM （tumor, node, and metastasis） system. The survival of patients with small AgNOR area in MIB-1-positive cells is better than that of patients with large AgNOR area. Molecular, biological （AgNOR area in MIB-l-positive cells）, and clinicopathological （greatest tumor dimension, metastases to regional lymph nodes, histology, and differentiation） parameters are independent prognostic factors of NSCLC.Conclusion： The AgNOR area in MIB- 1-positive cells is related to clinicopathological parameters and survival in NSCLC. 展开更多
关键词 Argyrophilic nucleolar organizer region （AgNOR） MIB-1 survival non-small cell lung cancer （NSCLC）
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Gene ORGANizer在小耳畸形中的应用 认领 引用
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作者 唐宏涛 潘博 《中国美容整形外科杂志》 CAS 2022年第12期736-739,I0008,I0009,共4页
目的探究Gene ORGANizer在小耳畸形的候选基因及伴发综合征相关研究中的应用。方法自2021年10月至2022年1月,中国医学科学院北京协和医学院整形外科医院外耳整形再造一科采用“Gene ORGANizer”工具,基于现有遗传疾病及表型,通过条件筛... 目的探究Gene ORGANizer在小耳畸形的候选基因及伴发综合征相关研究中的应用。方法自2021年10月至2022年1月,中国医学科学院北京协和医学院整形外科医院外耳整形再造一科采用“Gene ORGANizer”工具,基于现有遗传疾病及表型,通过条件筛选,检索并整理小耳畸形的候选基因及综合征。结果共获得53类与小耳畸形相关的疾病/综合征,共累及134个候选基因。结论Gene ORGANizer是一种能较好地将基因与遗传疾病或表型、器官三者关联的应用工具,我们在小耳畸形研究中,初步利用该工具,得到了潜在候选基因及相关综合征,并由此简要总结了部分综合征表型。 展开更多
关键词 小耳畸形 Gene ORGANizer 基因 综合征
Reg Organizer史上最强之注册表工具 认领 引用
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作者 徐海斌 《家庭电脑世界》 2003年第6期111-113,共3页
因为Windows自带的注册表编辑功能太弱．因此第三方的注册表编辑器工具非常多。在这些工具中，功能最强大的当数Reg Organizer．它不仅具备强大的注册表编辑修改功能，而且还具备ini文件编辑、注册表清理以及强大的注册表数据搜索替换... 因为Windows自带的注册表编辑功能太弱．因此第三方的注册表编辑器工具非常多。在这些工具中，功能最强大的当数Reg Organizer．它不仅具备强大的注册表编辑修改功能，而且还具备ini文件编辑、注册表清理以及强大的注册表数据搜索替换功能，是注册表“玩”家必备的超级工具。 展开更多
关键词 Reg Organizer 注册表工具 数据搜索替换功能 文件编辑 Windows系统
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Organizer涉足工作组领域 认领 引用
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作者 Gregg Keizer 伍颖文 《个人电脑》 EI 1995年第6期22-23,共2页
Lotus Organizer 2.0(Lotus个人信息管理器的最新产品)已成功地加入了一些重要的群组安排功能,但它作为最易使用的PIM产品的声望却秋毫未损。这种99美元的产品保持了Day-Timer似的笔记本外观,带有环扣装饰和“狗耳朵”页面角签。你可以... Lotus Organizer 2.0(Lotus个人信息管理器的最新产品)已成功地加入了一些重要的群组安排功能,但它作为最易使用的PIM产品的声望却秋毫未损。这种99美元的产品保持了Day-Timer似的笔记本外观,带有环扣装饰和“狗耳朵”页面角签。你可以加入新的部分,改制旧的部分。 展开更多
关键词 工作组 待办事项 先前版本 organizer 管理器 个人信息 电话模块 地址薄 交叉参考信息 适用范围
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The Effects of Teaching With Graphic Organizers on the Thinking Intelligence of Students 认领 引用
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作者 I-Ching Chen Jeng-fung Hung 《US-China Education Review(A)》 2014年第4期261-267,共7页
This study sought to design a pedagogical activity using multiple graphic organizers to enhance the thinking intelligence of students. The study consisted of a quasi-experiment with a nonequivalent group and pretest-p... This study sought to design a pedagogical activity using multiple graphic organizers to enhance the thinking intelligence of students. The study consisted of a quasi-experiment with a nonequivalent group and pretest-posttest design. The targets of the study were students aged 11. An experimental teaching session was conducted continuously for 12 weeks to compare the effects of teaching with multiple graphic organizers and teaching with concept mapping on the thinking intelligence of students in the experimental groups as compared with that of the students in the control group （CG）. To examine the differences in the thinking intelligence of students, results of the study were analyzed with Analysis of Covariance （ANCOVA）. Data analysis showed that the students who had received teaching with multiple graphic organizers had better thinking intelligence as compared with the students who were taught with the concept mapping method and that there was a significant effect size. This indicates that multiple graphic organizers produce significant positive results on the thinking intelligence of students. 展开更多
关键词 multiple graphic organizer thinking intelligence concept mapping
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Graphic Organizers and Reading Comprehension Ability: Evidence From Iranian EFL University Students 认领 引用
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作者 Reza Biria Mohammad Mahdi Sharifi 《Sino-US English Teaching》 2013年第5期358-365,共8页
The present study investigated the impact from GOs （Graphic Organizers） upon reading comprehension ability. To this end, an OPT （Oxford Placement Test） was administered to a research population （N = 354） in orde... The present study investigated the impact from GOs （Graphic Organizers） upon reading comprehension ability. To this end, an OPT （Oxford Placement Test） was administered to a research population （N = 354） in order to homogenize it. On the basis of the test results, the population was sorted into three groups of reading-low, reading-mid, and reading-high students. Sixty participants with the lowest level of reading comprehension proficiency were randomly selected and assigned to an EG （Experimental Group） （N = 30） and a CG （Control Group） （N = 30）. Afterwards, a TOEFL （Test of English as a Foreign Language） reading comprehension pretest was administered to both groups in order to determine their current level of reading proficiency. Then, the EG received 10 successive 90-minute sessions on GOs as post-reading strategies for expository text comprehension, while the CG received the same amount of treatment on other post-reading strategies. In the end, another TOEFL reading comprehension posttest was administered to the research groups to measure their reading comprehension performance level after the treatment. The results revealed that GOs were statistically more significant and effective for the low-skilled readers than other post-reading strategies. 展开更多
关键词 GOs （graphic organizers） text structure reading comprehension strategies expository text readingcomprehension ability
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Gorgeous Eight Years:SPINEXPO Moving into A New Journey Interview with Ms. Karine Van Tassel,the founder and organizer of SPINEXPO 认领 引用
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《China Textile》 2011年第1期39-41,共3页
Since the first International Textile Exhibition created by SPINEXPO in March 2003, Ms. Karine Van Tassel, the founder and organizer of SPINEXPO, dedicates herself to the display of the
关键词 Karine Van Tassel,the founder and organizer of SPINEXPO Gorgeous Eight Years
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用Media Organizer管理你的海量文件 认领 引用
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作者 杨书琴 《办公自动化》 2005年第5期46-46,共1页
硬盘里的图书、游戏、电影、音乐和软件多了,查找起来确实非常繁琐.如何能解决此类问题呢?"Media Organizer"这款软件,恰恰为有此遭遇的朋友解除了困扰.
关键词 Organizer Media 文件 管理 软件 硬盘 解除
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用Media Organizer管理你的海量文件 认领 引用
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作者 杨书琴 《电脑技术——Hello-IT》 2005年第2期28-29,共2页
关键词 “Media Organizer”软件 文件管理 空数据库 备份
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电子效率手册——Lotus Organizer 认领 引用
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作者 王珊 《文体用品与科技》 1996年第1期20-20,共1页
关键词 电子效率手册 信息管理软件 Lotus Organizer
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把Word和Organizer连结在一起 认领 引用
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作者 Woody Leonhard Vincent Chen 陆伟文 《电子与电脑》 1995年第9期55-57,共3页
苏格兰的谚语说,除了坏名声和长指甲,什么事都要付出辛苦才能有所获,可我们事先那里知道这件事有这么多的磨难。开始时事情好象很单纯,Tim Longacre从CompuServe连网服务部的GO WOPR技术支持论坛发来一份信息。他想在Word forWindows中... 苏格兰的谚语说,除了坏名声和长指甲,什么事都要付出辛苦才能有所获,可我们事先那里知道这件事有这么多的磨难。开始时事情好象很单纯,Tim Longacre从CompuServe连网服务部的GO WOPR技术支持论坛发来一份信息。他想在Word forWindows中用一小段三步宏过程来做以下的事:首先,在一个人名上双点击,然后,在一个“Lookup”的工具条按钮上点击。最后,使Word forWindows转到Lotus Organizer。 展开更多
关键词 应用程序 Word Organizer
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A Literature Review on the Effects of Graphic Organizers on Reading Comprehension 认领 引用
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作者 李秋东 《海外英语》 2018年第8期231-233,共3页
Reading texts serve as an influx of comprehensible input for English learners. Graphic organizer is a decent way of demonstrating the discourse structures or organizational patterns of a text, which will enormously fa... Reading texts serve as an influx of comprehensible input for English learners. Graphic organizer is a decent way of demonstrating the discourse structures or organizational patterns of a text, which will enormously facilitate reading comprehension. This study would give a literature review on the impact of graphic organizers on English reading comprehension. Finally, some suggestions were proposed for future studies. Hopefully, the review will shed some light on reading studies and instructions in an EFL pedagogical context. 展开更多
关键词 English reading comprehension graphic organizer(GO) EFL context
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依托Graphic Organizer解构、再构文本——以外研版新标准(一年级起点)四年级上册Module 6 Unit 1 It didn’t become gold.一课为例 认领 引用
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作者 林琳 杨晓莉 《福建教育》 2021年第9期49-51,共3页
Graphic Organizer能将人的思维活动有序化,简明扼要地外显思考的结果。教师在文本解读时借助Graphic Organizer将思考具象化,不仅可以使教学思路更清晰,还有利于引导学生解构、再构文本,提高教学成效。
关键词 Graphic Organizer 文本解读
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Host & Organizer etc.of the 5th Zhengzhou International Superhard Materials and Related Products Conference 认领 引用
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《金刚石与磨料磨具工程》 CAS 北大核心 2008年第S1期23-23,共1页
关键词 Host Organizer etc.of the 5 Zhengzhou International Superhard Materials and Related Products Conference
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The emerging role of ferroptosis in the pathological development and progression of sepsis 认领 引用 被引量：4
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作者 Hui-Ting Zhou Jie Huang +2 位作者 Ya-Kun Liu Jiang-Huai Wang Jian Wang 《Military Medical Research》 SCIE CAS CSCD 2026年第4期629-658,共30页
Ferroptosis,a form of iron-dependent regulated cell death(RCD),is emerging as a critical mechanism in the pathogenesis and progression of sepsis.This review highlights the intricate molecular pathways and hallmark fea... Ferroptosis,a form of iron-dependent regulated cell death(RCD),is emerging as a critical mechanism in the pathogenesis and progression of sepsis.This review highlights the intricate molecular pathways and hallmark features of ferroptosis,including lipid peroxidation,dysregulation of iron metabolism,and glutathione depletion,which exacerbate sepsis progression and sepsis-associated multi-organ damage.The systemic interactions of ferroptosis with inflammation,innate,and adaptive immunity,and organ injury are elucidated,emphasizing the role ferroptosis plays both in immunity including sepsis-associated immune cell damage/dysfunction,immune dysregulation,and immunosuppression,and in sepsis-associated multi-organ injury such as acute lung injury(ALI),acute kidney injury(AKI),acute hepatic injury(AHI),acute intestinal injury,septic cardiomyopathy,and septic encephalopathy.Therapeutic strategies targeting ferroptosis hold promise for improving sepsis outcomes.Approaches include pharmacological interventions of ferroptosis-associated pathways,nanoparticle-based delivery systems,and combinatorial therapies aimed at preventing immune dysfunction and protecting against multi-organ failure.Nonetheless,challenges remain in translating preclinical findings into clinical application,necessitating further research into ferroptosis-specific regulatory networks.This review underscores the potential of therapeutics targeting ferroptosis as a transformative approach to addressing sepsis,paving the way for innovative and precision-based clinical interventions. 展开更多
关键词 Sepsis Ferroptosis Lipid peroxidation Inflammation Immune dysregulation Organ damage Treatment
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Lattice Anchoring Stabilizesα-FAPbI3 Perovskite for High-Performance X-Ray Detectors 认领 引用 被引量：3
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作者 Yu-Hua Huang Su-Yan Zou +5 位作者 Cong-Yi Sheng Yu-Chuang Fang Xu-Dong Wang Wei Wei Wen-Guang Li Dai-Bin Kuang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第1期337-354,共18页
Formamidinium lead iodide(FAPbI3)perovskite exhibits an impressive X-ray absorption coefficient and a large carrier mobility-lifetime product(μτ),making it as a highly promising candidate for X-ray detection appl... Formamidinium lead iodide(FAPbI3)perovskite exhibits an impressive X-ray absorption coefficient and a large carrier mobility-lifetime product(μτ),making it as a highly promising candidate for X-ray detection application.However,the presence of larger FA+cation induces to an expansion of the Pb-I octahedral framework,which unfortunately affects both the stability and charge carrier mobility of the corresponding devices.To address this challenge,we develop a novel low-dimensional(HtrzT)PbI3 perovskite featuring a conjugated organic cation(1H-1,2,4-Triazole-3-thiol,HtrzT+)which matches well with theα-FAPbI3 lattices in two-dimensional plane.Benefiting from the matched lattice between(HtrzT)PbI3 andα-FAPbI3,the anchored lattice enhances the Pb-I bond strength and effectively mitigates the inherent tensile strain of theα-FAPbI3 crystal lattice.The X-ray detector based on(HtrzT)PbI3(1.0)/FAPbI3 device achieves a remarkable sensitivity up to 1.83×105μC Gyair−1 cm−2,along with a low detection limit of 27.6 nGyair s−1,attributed to the release of residual stress,and the enhancement in carrier mobility-lifetime product.Furthermore,the detector exhibits outstanding stability under X-ray irradiation with tolerating doses equivalent to nearly 1.17×106 chest imaging doses. 展开更多
关键词 α-FAPbI3perovskite Conjugated organic cation Lattice anchoring Phase stability X-ray detectors
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