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Treatment Effects of Pancreatogenic Diabetes Mellitus(Qi and Yin Deficiency Syndrome)Using Zicui Xiaodu Decoction Combined with Conventional Western Medicine 认领 引用
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作者 Qin WANG Yuanjun HE +1 位作者 Xiaojun YANG Baijun QIN 《Medicinal Plant》 2026年第4期50-55,共6页
[Objectives]To investigate the effects of Zicui Xiaodu Decoction combined with conventional Western medicine on endocrine and exocrine functions,as well as pancreatic inflammation,in patients diagnosed with pancreatog... [Objectives]To investigate the effects of Zicui Xiaodu Decoction combined with conventional Western medicine on endocrine and exocrine functions,as well as pancreatic inflammation,in patients diagnosed with pancreatogenic diabetes mellitus(T3cDM,qi and yin deficiency syndrome).[Methods]A retrospective analysis was performed on the clinical data of 30 patients diagnosed with T3cDM.The control group(n=15)received conventional Western medical treatment,whereas the observation group(n=15)was additionally administered Zicui Xiaodu Decoction.The treatment duration was 12 weeks.Comparative analyses were conducted between the two groups to evaluate differences in traditional Chinese medicine(TCM)syndrome scores,glycemic indicators(FPG,2hPG,and HbA1c),pancreatic islet function(FCP and 2hCP),pancreatogenic exocrine function(FE-1),and inflammatory markers(CRP,IL-6,amylase,and lipase)before and after treatment.[Results]After treatment,the total effective rate of TCM syndromes in the observation group(86.7%)exceeded that of the control group(66.7%),but this difference was not statistically significant(P>0.05).The observation group demonstrated significantly greater improvements in FPG,2hPG,and HbA1c compared to the control group(P<0.05).Enhancements in FE-1 and 2hCP levels were markedly superior in the observation group(P<0.01).The reductions in CRP,IL-6,amylase,and lipase were also significantly more pronounced in the observation group relative to the control group(P<0.05).No statistically significant difference was observed in the incidence of adverse reactions between the two groups.Correlation analysis revealed a significant negative association between IL-6 levels and both FE-1 and C-peptide in the observation group(P<0.05).[Conclusions]Zicui Xiaodu Decoction combined with Western medicine can effectively enhance blood glucose regulation,as well as improve both endocrine and exocrine pancreatic functions and reduce inflammatory status in patients with T3cDM.The underlying mechanism may involve tonifying qi and nourishing yin,clearing heat and detoxifying,and promoting blood circulation while removing blood stasis to inhibit chronic pancreatic inflammation. 展开更多
关键词 Pancreatogenic diabetes mellitus(T3cDM) Zicui Xiaodu Decoction Pancreaticosplenic homology Clinical observation
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Pancreatogenic diabetes:Pathophysiology,diagnosis,and management challenges 认领 引用 被引量：1
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作者 Duo Wang Yan Jiao 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第11期126-130,共5页
Pancreatogenic diabetes,also known as type 3c diabetes,arises from pancreatic dysfunction due to conditions such as chronic pancreatitis and pancreatic cancer.This form of diabetes is characterized by both endocrine a... Pancreatogenic diabetes,also known as type 3c diabetes,arises from pancreatic dysfunction due to conditions such as chronic pancreatitis and pancreatic cancer.This form of diabetes is characterized by both endocrine and exocrine pancreatic insufficiency,leading to insulin deficiency,glycemic variability,and maldigestion.The diagnostic process remains complex,as it shares clinical features with type 2 diabetes,and there are no standardized diagnostic criteria.Current treatment approaches include insulin therapy and pancreatic enzyme replacement therapy,along with nutritional support.However,the efficacy of oral hypoglycemic agents is limited,particularly in the presence of exocrine insufficiency.Epidemiological data indicate a significant overlap between pancreatogenic diabetes and pancreatic cancer,necessitating enhanced screening in high-risk populations.In this minireview,we highlight the pathophysiological mechanisms,diagnostic challenges,and current management strategies,emphasizing the need for improved diagnostic criteria and individualized treatment regimens. 展开更多
关键词 Pancreatogenic diabetes Chronic pancreatitis Insulin therapy Pancreatic enzyme replacement therapy Glycemic control Pancreatic cancer
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New-onset diabetes mellitus after distal pancreatectomy:Incidence,predictors and clinical impact 认领 引用
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作者 Zoi Gkiafi Sofia Rozani 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第6期70-78,共9页
New-onset diabetes mellitus(NODM)represents a significant postoperative concern following distal pancreatectomy,arising from loss of functionalβ-cell mass and potential alterations in remnant pancreatic perfusion.Wit... New-onset diabetes mellitus(NODM)represents a significant postoperative concern following distal pancreatectomy,arising from loss of functionalβ-cell mass and potential alterations in remnant pancreatic perfusion.With increasing use of distal pancreatectomy for benign and malignant conditions,recognition of its metabolic consequences has become critical in long-term patient management.This review examines current evidence on the incidence,determinants,and clinical relevance of NODM after distal pancreatectomy.Published studies demonstrate a broad range of incidence rates,reflecting variability in surgical techniques,underlying disease processes,and diagnostic criteria for postoperative diabetes.Factors such as preoperative glucose intolerance,pancreatic steatosis,patient age,and the volume of preserved pancreatic tissue appear to play important roles in determining postoperative endocrine function.Additionally,technical considerations-including splenic preservation and maintenance of splenic vessel integrity,may influence the risk of NODM.Clinically,the development of NODM is associated with increased healthcare utilization,lifestyle adjustments,and potential long-term cardiovascular and metabolic complications.This review underscores the importance of early detection,risk stratification,and evidence-based followup strategies,while highlighting areas requiring further research to better understand and mitigate NODM after distal pancreatectomy. 展开更多
关键词 New-onset diabetes Distal pancreatectomy Pancreatectomy Type 3c diabetes Pancreatogenic diabetes
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Central pancreatectomy:An uncommon but potentially optimal choice of pancreatic resection 认领 引用 被引量：2
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作者 Dimitrios Oikonomou Ricky H Bhogal Vasileios K Mavroeidis 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2025年第2期119-127,共9页
Benign,premalignant or low-grade malignant pancreatic tumors are increasingly diagnosed owing to the widespread uptake of cross-sectional imaging.Surgical excision is a potential treatment option for these tumors.Panc... Benign,premalignant or low-grade malignant pancreatic tumors are increasingly diagnosed owing to the widespread uptake of cross-sectional imaging.Surgical excision is a potential treatment option for these tumors.Pancreatoduodenectomy and distal pancreatectomy are the standard resections for tumors located in the pancreatic head-neck or body-tail,respectively,and not uncommonly sacrifice a significant amount of healthy pancreatic parenchyma.Central pancreatectomy(CP)is a parenchyma-sparing procedure,initially performed by Dagradi and Serio in 1982,in a patient with pancreatic neck insulinoma.Since then,an increasing number of cases are being performed worldwide,either via open or minimally invasive surgical access.Additionally,pancreatic enucleation is reserved for tumors<3 cm,without involvement of the main pancreatic duct.CP remains an alternative approach in selected cases,albeit in the presence of some controversies,such as its use in early pancreatic ductal adenocarcinoma or metastatic deposits to the central aspect of the pancreas from other malignancies.In recent years,clarity is lacking as regards indications for CP,and despite accumulating evidence in favor of limited resections for suitable pancreatic tumors,no evidence-based consensus guidelines are yet available.Nevertheless,it appears that appropriate patient selection is of paramount importance to maximize the advantages of preservation of endocrine and exocrine pancreatic functions as well as to mitigate the risks of higher complication rates.In this comprehensive review,we explore the role of CP in the treatment of lesions located in the neck and proximal body of the pancreas. 展开更多
关键词 Central/middle/median pancreatectomy Pancreatoduodenectomy Distal pancreatectomy Pancreatic tumors Exocrine/endocrine pancreatic function Type 3c pancreatogenic diabetes mellitus
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Relationship between the exocrine and endocrine pancreas after acute pancreatitis 认领 引用 被引量：11
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作者 Stephanie L M Das James I C Kennedy +3 位作者 Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov 《World Journal of Gastroenterology》 SCIE CAS 2014年第45期17196-17205,共10页
AIM: To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.
关键词 Pancreatogenic diabetes Pancreatic exocrine insufficiency Acute pancreatitis Endocrine insufficiency
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Diagnosis and treatment of diabetes mellitus in chronic pancreatitis 认领 引用 被引量：31
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作者 Nils Ewald Philip D Hardt 《World Journal of Gastroenterology》 SCIE CAS 2013年第42期7276-7281,共6页
Diabetes secondary to pancreatic diseases is commonly referred to as pancreatogenic diabetes or type 3c diabetes mellitus.It is a clinically relevant condition with a prevalence of 5%-10%among all diabetic subjects in... Diabetes secondary to pancreatic diseases is commonly referred to as pancreatogenic diabetes or type 3c diabetes mellitus.It is a clinically relevant condition with a prevalence of 5%-10%among all diabetic subjects in Western populations.In nearly 80%of all type 3c diabetes mellitus cases,chronic pancreatitis seems to be the underlying disease.The prevalence and clinical importance of diabetes secondary to chronic pancreatitis has certainly been underestimated and underappreciated so far.In contrast to the management of type 1 or type2 diabetes mellitus,the endocrinopathy in type 3c is very complex.The course of the disease is complicated by additional present comorbidities such as maldigestion and concomitant qualitative malnutrition.General awareness that patients with known and/or clinically overt chronic pancreatitis will develop type 3c diabetes mellitus(up to 90%of all cases)is rather good.However,in a patient first presenting with diabetes mellitus,chronic pancreatitis as a potential causative condition is seldom considered.Thus many patients are misdiagnosed.The failure to correctly diagnose type 3 diabetes mellitus leads to a failure to implement an appropriate medical therapy.In patients with type 3c diabetes mellitus treating exocrine pancreatic insufficiency,preventing or treating a lack of fat-soluble vitamins(especially vitamin D)and restoring impaired fat hydrolysis and incretin secretion are key-features of medical therapy. 展开更多
关键词 Diabetes mellitus Chronic pancreatitis Type 3c diabetes Pancreatogenic diabetes Pancreatitis
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Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm 认领 引用 被引量：4
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作者 Gianpaolo Balzano Michele Carvello +7 位作者 Lorenzo Piemonti Rita Nano Riccardo Ariotti Alessia Mercalli Raffaella Melzi Paola Maffi Marco Braga Carlo Staudacher 《World Journal of Gastroenterology》 SCIE CAS 2014年第14期4030-4036,共7页
AIM: To evaluate the safety and feasibility of laparoscopic spleen-preserving distal pancreatectomy (LSPDP) with autologous islet transplantation (AIT) for benign tumors of the pancreatic body-neck.
关键词 Pancreas Benign neoplasm Laparoscopy Minimally invasive treatment Spleen preservation Pancreatogenic diabetes Autologous islet transplantation
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Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a specialist diabetes team 认领 引用 被引量：4
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作者 Vasileios K Mavroeidis Jennifer Knapton +1 位作者 Francesca Saffioti Daniel L Morganstein 《World Journal of Diabetes》 SCIE 2024年第4期598-605,共8页
Pancreatic surgery units undertake several complex operations,albeit with consi-derable morbidity and mortality,as is the case for the management of complicated acute pancreatitis or chronic pancreatitis.The centralis... Pancreatic surgery units undertake several complex operations,albeit with consi-derable morbidity and mortality,as is the case for the management of complicated acute pancreatitis or chronic pancreatitis.The centralisation of pancreatic surgery services,with the development of designated large-volume centres,has contribu-ted to significantly improved outcomes.In this editorial,we discuss the complex associations between diabetes mellitus(DM)and pancreatic/periampullary disease in the context of pancreatic surgery and overall management of complex pancreatitis,highlighting the consequential needs and the indispensable role of specialist diabetes teams in support of tertiary pancreatic services.Type 3c pan-creatogenic DM,refers to DM developing in the setting of exocrine pancreatic disease,and its identification and management can be challenging,while the glycaemic control of such patients may affect their course of treatment and outcome.Adequate preoperative diabetes assessment is warranted to aid identification of patients who are likely to need commencement or escalation of glucose lowering therapy in the postoperative period.The incidence of new onset diabetes after pancreatic resection is widely variable in the literature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal loss in the context of severe pancreatitis.Early involvement of a specialist diabetes team is essential to ensure a holistic management.In the current era,large volume pancreatic surgery services commonly abide by the principles of enhanced recovery after surgery,with inclusion of provisions for optimisation of the perioperative glycaemic control,to improve outcomes.While various guidelines are available to aid perioperative management of DM,auditing and quality improvement platforms have highlighted deficiencies in the perioperative management of diabetic patients and areas of required improvement.The need for perioperative support of diabetic patients by specialist diabetes teams is uniformly underlined,a fact that becomes clearly more prominent at all different stages in the setting of pancreatic surgery and the management of complex pancreatitis.Therefore,pancreatic surgery and tertiary pancreatitis services must be designed with a provision for support from specialist diabetes teams.With the ongoing accumulation of evidence,it would be reasonable to consider the design of specific guidelines for the glycaemic management of these patients. 展开更多
关键词 Pancreatectomy Pancreatoduodenectomy Whipple’s Pancreatitis Diabetes specialist Type 3c pancreatogenic diabetes mellitus
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Post-acute pancreatitis diabetes:A complication waiting for more recognition and understanding 认领 引用 被引量：7
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作者 Diego García-Compeán Alan R Jiménez-Rodríguez +3 位作者 Juan M Muñoz-Ayala José A González-González Héctor J Maldonado-Garza Jesús Z Villarreal-Pérez 《World Journal of Gastroenterology》 SCIE CAS 2023年第28期4405-4415,共11页
Post-acute pancreatitis diabetes(PAPD)is the second most common type of diabetes below type 2 diabetes mellitus.Due to the boom in research on this entity carried out during the last decade,its recognition has increas... Post-acute pancreatitis diabetes(PAPD)is the second most common type of diabetes below type 2 diabetes mellitus.Due to the boom in research on this entity carried out during the last decade,its recognition has increased.However,much of the medical community still does not recognize it as a medium and long-term complication of acute pancreatitis(AP).Recent prospective cohort studies show that its incidence is about 23%globally and 34.5%in patients with severe AP.With the overall increase in the incidence of AP this complication will be certainly seen more frequently.Due to its high morbidity,mortality and difficult control,early detection and treatment are essential.However,its risk factors and pathophysiological mechanisms are not clearly defined.Its diagnosis should be made excluding pre-existing diabetes and applying the criteria of the American Diabetes Association after 90 d of resolution of one or more AP episodes.This review will show the evidence published so far on the incidence and prevalence,risk factors,possible pathophysiological mechanisms,clinical outcomes,clinical characteristics and preventive and corrective management of PAPD.Some important gaps needing to be clarified in forthcoming studies will also be discussed. 展开更多
关键词 Acute pancreatitis Diabetes mellitus Chronic pancreatitis Post-pancreatitis diabetes Pancreatogenic diabetes
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