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Microstructure and properties of Cu-Ni-Co-Si alloy designed by cluster formula approach 认领 引用
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作者 Shi-fang LI Zhu XIAO +3 位作者 Xiang-peng MENG Zhou LI Yan-lin JIA Yan-bin JIANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第3期872-886,共15页
A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was syst... A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was systematically investigated.The strengthening mechanism and electrical conductivity of the alloy were discussed in detail.The optimal thermomechanical treatment process was as follows:solid solution→80%cold rolling→(450℃,4 h)aging→50%cold rolling→(400℃,4 h)aging.The designed alloy achieved excellent comprehensive properties with a microhardness of HV 260,a yield strength of 843 MPa,a tensile strength of 884 MPa,and an electrical conductivity of 42.6%(IACS).Compared to direct aging treatment,the designed alloy subjected to multi-stage thermomechanical treatment had refined grains,high density of dislocations,and accelerated of precipitation of(Ni,Co)2Si precipitates.High strength was mainly attributed to the combined effect of dislocation strengthening,work hardening and sub-grain strengthening,while good electrical conductivity was maintained through the precipitation of the large number of nanoparticles. 展开更多
关键词 Cu-Ni-Co-Si alloys cluster formula approach thermomechanical treatment microstructure strengthening mechanism
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Soufeng Yuchuan formula(搜风愈喘方)alleviates asthma airway inflammation and suppresses the progression of asthma by inhibiting ferroptosis in airway epithelial cells 认领 引用
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作者 WEI Mumu YAN Xiaoyu +2 位作者 ZHANG Yujing ZHANG Xinxin YAN Yongbin 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第1期73-84,共12页
OBJECTIVE: To explore whether Soufeng Yuchuan(搜风愈喘, SFYC) formula alleviates asthma by promoting ferroptosis of airway epithelial cells. METHODS: A chronic asthma rat model was established using ovalbumin(OVA) com... OBJECTIVE: To explore whether Soufeng Yuchuan(搜风愈喘, SFYC) formula alleviates asthma by promoting ferroptosis of airway epithelial cells. METHODS: A chronic asthma rat model was established using ovalbumin(OVA) combined with aluminum hydroxide sensitization and OVA nebulization stimulation. Lung tissue pathology was assessed via hematoxylin and eosin staining and periodic acid-Schiff staining. Lung tissue ultrastructure was observed using transmission electron microscopy. Serum cytokine levels were measured by enzyme-linked immunosorbent assay. Malondialdehyde(MDA), glutathione, and tissue ferrous ion content in rat lung tissues and cells were detected using commercial kits. Immunohistochemical staining was used to determine the expression levels of interleukin-13(IL-13) and interleukin-6(IL-6) in lung tissue. Western blotting was employed to detect the expression levels of transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), acyl-Co A synthetase longchain family member 4(ACSL4), glutathione peroxidase 4(GPX4), and solute carrier family 7 member 11(SLC7A11). Cell proliferation, apoptosis and reactive oxygen species(ROS) were evaluated using a cell counting kit-8 assay and flow cytometry. Intracellular lipid peroxidation was detected using a C11-BODIPY 581/591(C11-BODIPY) probe. RESULTS: SFYC formula effectively alleviates airway inflammation in asthmatic rats in a dose-dependent manner. It improves airway epithelial cell integrity, reduces alveolar wall thickening and expansion, inhibits goblet cell proliferation and mucus secretion, and decreases the expression of IL-6 and IL-13 in lung tissue, as well as the serum levels of IL-6, IL-13, interleukin-4(IL-4), and immunoglobulin E(Ig E). SFYC formula mitigates ferroptosis in lung tissue of asthmatic rats. At the cellular level, it promotes proliferation of rat airway epithelial cells, inhibits cell apoptosis, suppresses ROS, MDA, and lipid accumulation, reduces the expression of TFR1, TFR2, and ASCL4, and increases the expression of GPX4 and SLC7A11 to mitigate ferroptosis. CONCLUSION: SFYC formula alleviates asthma airway inflammation by inhibiting ferroptosis in airway epithelial cells, providing new insights and potential therapeutic targets for the development of new asthma treatment drugs. 展开更多
关键词 asthma asthma airway inflammation ferroptosis Soufeng Yuchuan formula
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Xijiaqi Formula attenuates cognitive dysfunction by inhibiting neuroinflammation and promoting neuroplasticity in rats with chronic heart failure 认领 引用
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作者 Jie Chen Xuefen Wu +8 位作者 Qian Zhang Hongcai Shang Wanting Li Linnan Zhou Xinyu Chu Guiyang Xia Huan Xia Xiaohong Wei Sheng Lin 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期73-88,共16页
Chronic heart failure(CHF)impairs cognitive function.Xijiaqi Formula(XJQ),a traditional Chinese medicine(TCM)used clinically to treat CHF,demonstrates potential for improving cognition in CHF patients.However,its prec... Chronic heart failure(CHF)impairs cognitive function.Xijiaqi Formula(XJQ),a traditional Chinese medicine(TCM)used clinically to treat CHF,demonstrates potential for improving cognition in CHF patients.However,its precise mechanism in treating post-CHF cognitive dysfunction remains unclear.This study systematically investigates XJQ’s effects on post-CHF cognitive dysfunction and the underlying mechanisms.The components of XJQ were identified through liquid chromatography-mass spectrometry.CHF was induced in rats via ligation of the left anterior descending coronary artery,followed by six weeks of XJQ treatment.Cardiac function was evaluated through echocardiography and hemodynamic parameters,while cognitive function was assessed using Morris water maze(MWM)and open field tests(OFT).XJQ treatment enhanced both cardiac and cognitive functions in CHF rats.Network pharmacology identified 12 core active components of XJQ and indicated its effect on cognitive dysfunction involved regulating synapses,inflammation,and phosphodiesterase 4(PDE4)-dependent cyclic adenosine monophosphate(cAMP)signaling.XJQ inhibited microglial and astrocyte activation,decreased proinflammatory cytokines,and mitigated neuronal damage.Notably,XJQ promoted synaptic repair and dendritic growth by downregulating PDE4 and upregulating cAMP,protein kinase A(PKA),cAMP-response element binding protein(CREB),brain-derived neurotrophic factor(BDNF),PSD95,and synapsin I levels.Molecular docking and Bio-layer interferometry assays confirmed direct binding of quercetin,kaempferol,isorhamnetin,and darutoside to PDE4.In conclusion,XJQ alleviates neuroinflammation and enhances synaptic plasticity to improve cognitive dysfunction in CHF rats via the PDE4/cAMP/PKA/CREB signaling pathway.These findings provide valuable insight into the heart-brain axis. 展开更多
关键词 Xijiaqi Formula Cognitive dysfunction Chronic heart failure Synaptic plasticity Neuroinflammation PDE4
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基于Penman-Monteith模型和PRA算法的番茄灌溉研究 认领 引用
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作者 张宇 郭文忠 林森 《吉林农业大学学报》 CAS CSCD 北大核心 2026年第2期367-376,共10页
灌溉是影响番茄产量的重要因素之一。为高效、精准地对番茄进行灌溉,以“齐达利”番茄展开试验,在灌溉决策模型中考虑作物实时状态,以Penman-Monteith(P-M)模型和知识推理算法相结合的方法对番茄灌溉展开研究。首先收集番茄灌溉的影响... 灌溉是影响番茄产量的重要因素之一。为高效、精准地对番茄进行灌溉,以“齐达利”番茄展开试验,在灌溉决策模型中考虑作物实时状态,以Penman-Monteith(P-M)模型和知识推理算法相结合的方法对番茄灌溉展开研究。首先收集番茄灌溉的影响因素和专家经验知识并将数据结构化,然后利用“自顶向下”和“自底向上”的模块化方法构建番茄知识图谱,然后应用路径排序算法(Path Ranking Algorith,PRA)计算灌溉调整值并对P-M模型计算的初始灌溉值进行调整,实现番茄的精准灌溉。知识推理中每个专家的灌溉调整策略均不相同,试验目标为番茄果实产量最大化,选择得分最高的专家灌溉推理值对灌溉进行调整。结果表明:基于Penman-Monteith模型和路径排序算法相结合的方法比传统P-M模型方法的果实总产量、单株果实均产量、果实均重、果实均重百分比分别提高了5346.1 g,178.2 g,5.2 g,2.22%,对比基于视觉经验方法分别提高了875.2 g,29.2 g,9.5 g,4.18%。表明该方法根据作物生长状态对作物灌溉进行了合理调整,为精确灌溉提供了新的思路。 展开更多
关键词 知识图谱 知识推理 精准灌溉 番茄 Penman-Monteith 路径排序算法
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Hua-Yi-Jie-Du formula ameliorates poly(I:C)-induced viral pneumonia by regulating ILC2 cells and NLRP3 activation 认领 引用
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作者 Xiao-Hong Li Ning Yang +7 位作者 Chun-Fei Zhang Die Qian Guo-Hui Yang Xin-Yan Yang Chun-Rong He Zhi-Dao Zhang Bi-Hong Dai Chun-Ping Wan 《Traditional Medicine Research》 2026年第6期50-59,共10页
Background:Hua-Yi-Jie-Du formula(HYJD)is a traditional Chinese medicine that has proven effective against viral pneumonia and was extensively used during the COVID-19 pandemic.This study investigates how HYJD influenc... Background:Hua-Yi-Jie-Du formula(HYJD)is a traditional Chinese medicine that has proven effective against viral pneumonia and was extensively used during the COVID-19 pandemic.This study investigates how HYJD influences group 2 innate lymphoid cell(ILC2)and nucleotide oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation in a mouse model of viral pneumonia.Methods:A mouse model of viral pneumonia was established through the administration of polyinosinic-polycytidylic acid(poly(I:C))via nasal drops.Histopathological analysis of lung tissue was conducted,alongside enzyme-linked immunosorbent assay to quantify cytokine levels in serum and bronchoalveolar lavage fluid(BALF).Flow cytometry was employed to detect ILC2 cells in lung tissue and spleen,while immunofluorescence techniques were utilized to visualize ILC2 cells in lung tissue.Transcriptomic sequencing was performed,and the results were validated using qRT-PCR and western blot analysis.Results:HYJD significantly ameliorated inflammatory infiltration in lung tissue,decreased mucus protein secretion,and reduced the serum levels of inflammatory cytokines interleukin(IL)-1β,IL-6,and tumor necrosis factor-alpha(TNF-α).Additionally,it lowered the expression of cytokines IL-4,IL-5,IL-13,IL-25,thymic stromal lymphopoietin(TSLP),and IL-33 in BALF,and reduced the differentiation of ILC2 cells in both lung tissue and spleen.Transcriptomic analysis and experimental validation revealed that HYJD downregulated the expression of NLRP3 related genes and proteins within the NOD-like receptor signaling pathway.Conclusion:The mechanism by which HYJD intervenes in acute lung injury associated with viral pneumonia may involve the reduction of ILC2 cells differentiation and the inhibition of NLRP3 activation. 展开更多
关键词 viral pneumonia Hua-Yi-Jie-Du formula ILC2 cells NLRP3 inflammatory response
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Effectiveness of the extensively hydrolyzed formulas in the management of infantile colic:A systematic review and metaanalysis 认领 引用
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作者 Konstantinos Dodos Tsampika-Vasileia Kalamara +5 位作者 Stylianos Xinias Antigoni Mavroudi Dorothea Kapoukranidou Antigoni Sarantaki Athina Diamanti Vasiliki E Georgakopoulou 《World Journal of Clinical Pediatrics》 2026年第1期252-260,共9页
BACKGROUND Infantile colic(IC)is a common,self-limiting condition marked by excessive,unexplained crying.Evidence on the use of extensively hydrolyzed formulas(eHFs)as a dietary intervention remains fragmented.AIM To ... BACKGROUND Infantile colic(IC)is a common,self-limiting condition marked by excessive,unexplained crying.Evidence on the use of extensively hydrolyzed formulas(eHFs)as a dietary intervention remains fragmented.AIM To systematically review and meta-analyze the effectiveness of eHFs in managing symptoms of IC.METHODS A comprehensive literature search of MEDLINE,Cochrane and Web of Science databases(1980-2025)identified randomized controlled trials and crossover studies assessing the efficacy of eHF in infants diagnosed with IC based on Wessel’s or ROME III criteria.Studies were included if they involved infants≤6 months old on partial or exclusive formula diets,and were excluded if the diagnosis was unclear.Data were synthesized qualitatively and through meta-analysis using odds ratios(OR)and 95%confidence intervals(CI).RESULTS Six studies met the inclusion criteria,with a total of 340 infants across intervention and comparator arms.In all studies,eHF significantly reduced crying duration and colic symptoms compared to regular formula or dicyclomine.The meta-analysis showed a pooled OR of 4.8(95%CI:2.53-9.11,P<0.05).Secondary outcomes such as stool consistency and parental quality of life were variably reported but tended to favor eHF.CONCLUSION eHF appear significantly more effective than standard formulas and pharmacologic comparators in reducing colicrelated symptoms.These findings support eHF as a viable dietary intervention for IC,though larger,wellcontrolled trials are warranted to confirm long-term outcomes. 展开更多
关键词 Infantile colic Extensively hydrolyzed formulas Crying duration Dietary intervention Formula-fed infants Cow’s milk protein allergy
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Exploring the mechanism of the Lianshi Jianpi formula(莲实健脾方)in treating impaired glucose tolerance:a network pharmacology,molecular docking,and experimental validation study 认领 引用
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作者 JIANG Mingqian WANG Tong +3 位作者 HUANG Bowei QIU Chen LIANG Yanbin YE Binhua 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第1期160-171,共12页
OBJECTIVE:To explore the bioactive constituents,key targets,signalling pathways,and molecular mechanisms of Lianshi Jianpi formula(莲实健脾方,LSJPF)in the treatment of impaired glucose tolerance(IGT)through network ph... OBJECTIVE:To explore the bioactive constituents,key targets,signalling pathways,and molecular mechanisms of Lianshi Jianpi formula(莲实健脾方,LSJPF)in the treatment of impaired glucose tolerance(IGT)through network pharmacology,molecular docking,and in vivo experiments.METHODS:The active ingredients and targets of LSJPF were identified using the Traditional Chinese Medicine Systems Pharmacology and HERB databases,whereas the IGT-related targets were sourced from Gene Cards,Dis Ge NET,and Pub Med.The overlap analysis identified potential targets of LSJPF.Protein-protein interaction networks and core targets were evaluated using the Search Tool for the Retrieval of Interacting Genes/Proteins and Cytoscape,and molecular docking confirmed the binding affinities.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using Metascape.The therapeutic mechanisms were validated in an animal IGT model.RESULTS:LSJPF contained 229 compounds,with 15 active compounds and 77 potential target proteins.The phosphatidylinositol-3-kinase(PI3K)-protein kinase B(AKT)signalling pathway emerged as a key IGT pathway.The KEGG enrichment analysis revealed the pivotal genes RAC-alpha serinehreonine-protein kinase(AKT1),heat shock protein 90 k Da alpha B1,and B-cell lymphoma 2 family protein,which predominantly interact with beta-sitosterol and beta-carotene,the major constituents of Semen Euryales,Semen lablab Album,Semen sojae Atricolor in LSJPF.Molecular docking revealed strong binding affinities between LSJPF and IGT-related targets.In an animal IGT model,LSJPF treatment prevented weight loss;reduced food and water intake;decreased blood glucose levels;improved insulin resistance;decreased serum triglyceride,cholesterol,and low-density lipoprotein cholesterol levels;alleviated liver pathology;and significantly increased the levels of phosphorylated adenosine 5'-monophosphate-activated protein kinase(AMPK),PI3K,and AKT,suggesting its potential role in regulating glucose and lipid metabolism.CONCLUSIONS:These findings reveal the potential of LSJPF as an IGT intervention that targets the AMPK/PI3K/AKT cascade,validating network pharmacology predictions and highlighting the role of multipathway mechanisms in metabolic diseases. 展开更多
关键词 impaired glucose intolerance AMP-activated protein kinases phosphatidylinositol-3-kinase protein kinase B signalling pathway medicinal dietary therapy Lianshi Jianpi diet formula
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Yiqi Huoxue formula(益气活血方)relieves heart failure with reduced ejection fraction in calcium/calmodulin-dependent protein kinaseⅡdelta B isoform and calcium/calmodulin-dependent protein kinaseⅡdelta C isoform transgenic mice by inhibiting myocardi 认领 引用
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作者 XU Jianglin SHI Xiaolu +11 位作者 LI Yan ZHOU Kun LI Peng LI Sinai LU Jinjin CHEN Yajun ZHAN Nannan ZHANG Ruotong CHENG Bairu LIN Qian WAN Jie LIU Jing 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第3期530-543,共14页
OBJECTIVE:To confirm the efficacy of Yiqi Huoxue formula(益气活血方,YQHX)on heart failure with reduced ejection fraction(HFr EF),and elucidate its potential effect on calcium homeostasis.METHODS:Cardiac specific calci... OBJECTIVE:To confirm the efficacy of Yiqi Huoxue formula(益气活血方,YQHX)on heart failure with reduced ejection fraction(HFr EF),and elucidate its potential effect on calcium homeostasis.METHODS:Cardiac specific calcium/calmodulindependent protein kinase II delta C isoform(Ca MKⅡδC)-overexpression transgenic mice(C-Ca MKⅡδC+/-Tg mice)and calcium/calmodulin-dependent protein kinase II delta B isoform(Ca MKⅡδB)-overexpression transgenic mice(C-Ca MKⅡδB+/-Tg mice)were established by clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9 technique,and their genotypes and phenotypes were identified thereafter.C57BL/6 mice and transgenic mice were divided into seven groups in random,each containing eight mice.The groups were Control group,Ca MKⅡδB model group,Ca MKⅡδB treatment group(B Treated),Ca MKⅡδB inhibitor group(B Inhibitor),Ca MKⅡδC model group(C Model),Ca MKⅡδC treatment group(C Treated),Ca MKⅡδC inhibitor group(C Inhibitor).B and C Treated groups were given YQHX once a day for 4 weeks by gavage.The cardiac function and structure were evaluated using echocardiogram.The myocardial cellular status and fibrosis were detected by hematoxylin and eosin staining and Masson staining.Calcium transients and calcium leakage from cardiac ventricular myocytes were detected to reflect calcium homeostasis,and the expressions of Ca MKⅡδB,Ca MKⅡδC,hypertrophy factors,calcium pathway-related genes,and the level of calcium handling proteins were assessed by western blotting and reverse transcription-quantitative polymerase chain reaction.RESULTS:We found Ca MKⅡδB and Ca MKⅡδC transgenic mice showed HFr EF phenotype.YQHX improved the systolic function of the Ca MKⅡδB transgenic mice,reduced the cross-sectional area of cardiomyocytes,inhibited the overexpression of Ca MKⅡδB and hypertrophy-related genes(B-type natriuretic peptide,myocyte enhancer factor 2,and atrial natriuretic factor),and increased calcium handling protein sarcoendoplasmic reticulum Ca^(2+)adenosine triphosphatase 2a(SERCA2a)and calcium capacity.YQHX improved the cardiac systolic function of Ca MKⅡδC transgenic mice,reduced the ventricular diameter and cardiomyocyte cross-sectional area,alleviated myocardial fibrosis,increased SERCA2a expression and calcium capacity,and reduced calcium leakage.CONCLUSION:Our results suggest that YQHX improved HFr EF by inhibiting Ca MKIIδB overexpression,which may be related to reduced expression of hypertrophyrelated factors,and increased SERCA2a expression to increase calcium reserve.In addition,YQHX improved HFr EF by inhibiting Ca MKIIδC overexpression,which may be related to reduce calcium leakage,and increase SERCA2a expression to increase calcium reserve. 展开更多
关键词 heart failure systolic calcium homeostasis Yiqi Huoxue formula calcium/calmodulin-dependent protein kinase II delta C isoform overexpression calcium/calmodulin-dependent protein kinase II delta B isoform overexpression
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Γ0(2)MODULAR FORMS AND ANOMALY CANCELLATION FORMULAS 认领 引用
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作者 Siyao LIU Yong WANG 《Acta Mathematica Scientia》 SCIE CSCD 2026年第1期119-130,共12页
In the references[4,11,12],the authors gave some modular forms overΓ0(2).In this note,we proceed with the study of cancellation formulas relating to the modular forms.
关键词 modular invariance cancellation formulas (a,b)type cancellation formulas
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Clinical outcomes of two lactose-free formulas in the management of acute childhood diarrhea 认领 引用
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作者 Nopaorn Phavichitr Ruangvith Tantibhaedhyangkul +4 位作者 Termpong Dumrisilp Sittichoke Prachuapthunyachart Wilaiporn Chanpreecha Panjachat Ratanamongkol Voranush Chongsrisawat 《World Journal of Clinical Pediatrics》 2026年第1期224-231,共8页
BACKGROUND Acute diarrhea is the most common gastrointestinal disease in children under five years of age and is associated with significant morbidity and mortality risks.Lactose-free formulas may be beneficial for ho... BACKGROUND Acute diarrhea is the most common gastrointestinal disease in children under five years of age and is associated with significant morbidity and mortality risks.Lactose-free formulas may be beneficial for hospitalized patients.AIM To compare the efficacy,safety,and cost-effectiveness of a medium-chain triglyceride-containing lactose-free formula(MLF)with a standard lactose-free formula(SLF)in children hospitalized with acute diarrhea.METHODS In this randomized,double-blind,controlled trial,children aged 6-24 months were randomized to receive MLF or SLF.The primary outcomes were the duration until diarrhea resolution and the frequency of stools after enrollment.Secondary outcomes included length of hospital stay,treatment costs,and caregiver satisfaction.RESULTS Forty-four children completed the study(MLF=22,SLF=22).The median duration of diarrhea after enrollment did not differ significantly between the groups,24.0 hours[interquartile range(IQR):21.5]vs 45.0 hours(IQR:49.0);P=0.293.The reduction in stool frequency was also comparable[7.5(IQR:5.8)vs 4.0(IQR:3.8)times/day;P=0.083].The Hodges-Lehmann estimated median difference in diarrhea duration was-4 hours(95%confidence interval:-26.0 to 2.0),supporting the noninferiority of MLF.The median length of hospital stay was 2 days in both groups.Formula costs were significantly lower in the MLF group(227.9 Thai Baht vs 373.6 Thai Baht;P<0.001).Caregiver satisfaction,product acceptance,and safety profiles were comparable between the groups.CONCLUSION MLF demonstrated noninferior clinical outcomes and safety compared to SLF,with a significant reduction in formula-related costs.MLF could be an appropriate alternative for the management of acute diarrhea in young children,especially in resource-constrained settings. 展开更多
关键词 Acute diarrhea Acute gastroenteritis Children Lactose-free formula Nutritional management
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A Cauchy integral formula and the related properties for inframonogenic functions valued in the Clifford algebra depending on parameters 认领 引用
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作者 DU Xiao-jing LIANG Xiao-tong XIE Yong-hong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2026年第2期314-327,共14页
Firstly,we obtain a Cauchy integral formula for inframonogenic functions which are solutions to the sandwich equation DfD=0 in the framework of parameter-depending Cliffordtype algebras.Secondly,the properities relati... Firstly,we obtain a Cauchy integral formula for inframonogenic functions which are solutions to the sandwich equation DfD=0 in the framework of parameter-depending Cliffordtype algebras.Secondly,the properities relating to Cauchy integral operators are discussed.Finally,the decompositions of the inframonogenic function are given. 展开更多
关键词 inframonogenic function Cauchy integral formula Clifford algebra depending on parameter
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Comparative characterization of triacylglycerols in human milk,infant formula,structured lipids,and plant oils using UPSFC-Q-TOF-MS 认领 引用
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作者 Jiayao Zhou Yan Chen +3 位作者 Jiadi Yan Chunlin Wang Xingguo Wang Wei Wei 《Grain & Oil Science and Technology》 EI CAS 2026年第1期11-20,共10页
Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic a... Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic acid rapeseed oil)were analyzed and compared using ultraperformance supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPSFC-Q-TOF-MS).Distinct TAG profiles were identified by lipidomics,principal component analysis(PCA),and heatmap visualization.Human milk was characterized by a high abundance of medium-and long-chain triacylglycerols(MLCTs),saturated-unsaturated-unsaturated(SUU)-type TAGs(sn-2 palmitic acid).In contrast,plant oils lacked MLCTs and SUU-type TAGs,containing mainly TAGs esterified long-chain polyunsaturated fatty acid.Breast milk contains about 27%MLCT,about 50%SUU-type triacylglycerols(which contain about 34%UPU-type triacylglycerols),which is significantly different from plant oils,structured fats and infant formulas.These findings provide a clear basis for optimizing the fat blend in infant formula to better mimic the unique TAG profile of human milk,thereby improving energy delivery and nutrient absorption for infants. 展开更多
关键词 Triacylglycerol Milk lipids Human milk Infant formula Plant oil Medium-and long-chain triacylglycerol Palmitic acid Mass spectrometry
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Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway 认领 引用
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作者 Shao-Pu Hu Yan-Ru Cai +4 位作者 Yang Liu Yu-Xi Guo Xue-Mei Jia Jian-Ming Jiang Qian Yang 《World Journal of Gastroenterology》 SCIE CAS 2026年第27期141-159,共19页
BACKGROUND Colitis-associated colorectal cancer(CAC)is a common type of malignant tumor that occurs in the digestive tract and poses a significant threat to human health.The traditional Chinese medicine preparation Hu... BACKGROUND Colitis-associated colorectal cancer(CAC)is a common type of malignant tumor that occurs in the digestive tract and poses a significant threat to human health.The traditional Chinese medicine preparation Hua-Zhuo-Jie-Du formula(HZJDF)has shown clinical efficacy in preventing CAC;however,the potential therapeutic mechanisms of this formula for treating CAC remain under explored.AIM To investigate the therapeutic efficacy and mechanism of HZJDF against CAC through applying an integrated research approach.METHODS We first established a CAC mouse model using the azoxymethane/dextran sulfate sodium induction method and then assessed the therapeutic effects of various doses of HZJDF on the CAC mice.Subsequently,we utilized a combination of network pharmacology and transcriptomics analyses to help predict the potential mechanisms by which HZJDF acts against CAC.Finally,we sought to validate these prediction findings through animal and cell experiments.RESULTS HZJDF significantly mitigated weight reduction and colon length shortening in a dose-dependent manner,enhanced the mice survival rates,lowered the disease activity index scores,diminished the tumor incidence and burden,and improved the pathological condition of the colon tissues in the CAC mice.The findings from the network pharmacology and transcriptomics analyses suggested that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway might be the potential mechanism through which HZJDF exerts its protective effects against CAC.In vivo studies showed that HZJDF diminished the quantity of Ki67-positive cells within the colon tissues of the CAC mice and lowered the levels of phosphorylated PI3K and AKT proteins.Meanwhile,in vitro studies indicated that serum containing HZJDF decreased the viability,proliferation,and migration of HT-29 and HCT116 cells in a dose-dependent manner,while also lowering the expression of key proteins linked to the PI3K/AKT signaling pathway.CONCLUSION HZJDF effectively alleviated CAC tumorigenesis by suppressing the PI3K/AKT signaling pathway,providing reliable evidence to support the appropriate utilization of HZJDF in CAC treatment. 展开更多
关键词 Hua-Zhuo-Jie-Du formula Colitis-associated colorectal cancer Network pharmacology Transcriptomics Phosphatidylinositol 3-kinase/protein kinase B signaling pathway
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Pinggan Yuyin Qingre formula(平肝育阴清热方)ameliorates meibomian gland dysfunction through the interleukin-17/nuclear factor kappa B pathway based on network pharmacology and experimental validation 认领 引用
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作者 GAO Yinli ZHANG Linhua +3 位作者 ZHANG Yaqiang ZHANG Liuhe ZHI Nan LIAN Haihong 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第1期172-182,共11页
OBJECTIVE:To investigate the pharmacological effects and underlying mechanisms of Pinggan Yuyin Qingre formula(平肝育阴清热方,PGYYQR)in the treatment of meibomian gland dysfunction(MGD)through network pharmacology and... OBJECTIVE:To investigate the pharmacological effects and underlying mechanisms of Pinggan Yuyin Qingre formula(平肝育阴清热方,PGYYQR)in the treatment of meibomian gland dysfunction(MGD)through network pharmacology and in vivo validation.METHODS:A mouse model of MGD was induced using the stearoyl-coenzyme a desaturase 1 inhibitor,followed by PGYYQR treatment for 2 weeks.MGD sign scoring,hematoxylin and eosin(HE)staining,oil red o(ORO)staining,and serum inflammatory cytokine analysis were conducted to assess the effects of PGYYQR on meibomian gland(MG)function,histopathology,and associated inflammation.Network pharmacology was employed to identify the active compounds and potential targets of PGYYQR.Molecular mechanisms were further investigated using Western blotting,reverse transcription quantitative real-time polymerase chain reaction,and reactive oxygen species(ROS)assays.RESULTS:PGYYQR treatment significantly reduced the scores of MG orifice obstruction and meibum quality in MGD mice.HE and ORO staining further demonstrated that PGYYQR ameliorated glandular damage and lipid dysfunction.Enzyme-linked immunosorbent assay results revealed that PGYYQR markedly decreased the serum levels of key inflammatory cytokines,including interleukin(IL)-1β,IL-6,and tumor necrosis factor-α.Network pharmacology identified 162 active compounds and 598 target genes in PGYYQR.Among these,IL-6,IL-1β,matrix metalloproteinase-9,and C-X-C motif chemokine ligand 8 were recognized as core targets related to MGD and were mainly enriched in the IL-17uclear factor kappa B(NF-κB)signaling pathway.Further molecular analyses confirmed that PGYYQR significantly inhibited the IL-17/NF-κB axis by downregulating IL-17 expression and reducing phosphorylated NF-κB p65 levels at both the protein and m RNA levels in MG tissues.PGYYQR also effectively reduced ROS levels in the conjunctival tissues of MGD mice.CONCLUSION:PGYYQR effectively improves MG function and preserves local tissue morphology in MGD model mice,primarily by suppressing the inflammatory response through coordinated modulation of the IL-17/NF-κB signaling pathway and oxidative stress. 展开更多
关键词 meibomian gland dysfunction network pharmacology interleukin-17 NF-kappa B signal transduction reactive oxygen species Pinggan Yuyin Qingre formula
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Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder 认领 引用 被引量：1
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作者 Jia-Xing Tian Yan-Jiao Zhang +7 位作者 Yu-Xin Zhang Jia-Hua Wei Xin-Yi Fang Run-Yu Miao Kai-Le Ma Hui-Fang Guan Xin-Miao Wang Hao-Ran Wu 《World Journal of Diabetes》 SCIE 2026年第2期127-143,共17页
BACKGROUND Glycolipid metabolic disorder includes a series of chronic diseases that are closely associated with disturbances in both glucose and lipid metabolism.Jiangtang Tiaozhi formula(JTTZF)demonstrating significa... BACKGROUND Glycolipid metabolic disorder includes a series of chronic diseases that are closely associated with disturbances in both glucose and lipid metabolism.Jiangtang Tiaozhi formula(JTTZF)demonstrating significant hypoglycemic,lipidmodifying,and anti-inflammatory effects.However,the specific molecular mechanisms underlying JTTZF’s hepatoprotective effects and its ability to ameliorate glycolipid metabolic disorder remain largely unexplored.AIM To investigate how JTTZF improves glycolipid metabolic disorder using hepatic transcriptome and metabolome analyses.METHODS To induce glycolipid metabolic disorder,male C57BL/6J mice were fed a high-fat diet(HFD)for 12 weeks,after which they received an 8-week administration of JTTZF.Liver tissues were analyzed using transcriptomics and metabolomics.Real-time quantitative polymerase chain reaction validated key gene expression.RESULTS Metabolomics data revealed that JTTZF significantly regulated HFD-induced alterations in glycolipid metabolism,with notable changes in pathways such as the pentose phosphate pathway,steroid hormone biosynthesis,and purine metabolism.Transcriptomics profiles indicated that JTTZF exerted regulatory effects on lipid and glucose metabolism,primarily through pathways including peroxisome proliferators-activated receptor signaling,drug metabolism other enzymes,and regulation of lipolysis in adipocytes.Real-time quantitative polymerase chain reaction confirmed that JTTZF modulated pivotal genes associated with fatty acid synthesis,lipolysis,insulin resistance,energy metabolism,and inflammation.These findings suggest that JTTZF may act through multiple pathways to improve glycolipid metabolic disorder.CONCLUSION JTTZF can ameliorate the glycolipid metabolic disorder induced by HFD-diet by regulating lipid metabolism and improving insulin tolerance. 展开更多
关键词 Glycolipid metabolic disorder Hepatic transcriptome Hepatic metabolome Jiangtang Tiaozhi formula Multiomics
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Time period formulas for RC shear-wall multistory buildings 认领 引用
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作者 Ahmed M.El-Kholy Ahmed H.Abd-Allah +1 位作者 Mohamed Eissa Souma M.Abdelghany 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2026年第3期767-791,共25页
This paper presents new formulas for estimating the translational and rotational time periods of the prevailing reinforced concrete shear-wall multistory buildings(SWMBs)in Egypt.Forty distinct structural plans,featur... This paper presents new formulas for estimating the translational and rotational time periods of the prevailing reinforced concrete shear-wall multistory buildings(SWMBs)in Egypt.Forty distinct structural plans,featuring varying lateral and torsional stiffness,were rigorously prepared to create a sample of 142 SWMBs,with diverse heights,concrete strengths,and stiffness properties.A three-dimensional finite element modal analysis was conducted on the sample,and the first three vibration modes were identified.Regression analyses were performed using multiple combinations of eighteen geometric and mechanical parameters to derive the most accurate and simplest formulas for the translational and rotational periods.Additionally,lower-bound translational formulas were proposed for code implementation.Compared with reference modal analyses and period estimates calculated using the Egyptian code(ECL 201)alongside three international seismic codes—EC8,IBC,and UBC—the proposed formulas demonstrated superior reliability(95%based on a new criterion),followed by the UBC(61%)and ECL(56%).While the ECL ensured the safety of all buildings,it exhibited excessive conservativeness in underestimating the periods.The proposed formulas mitigated this conservativeness by ensuring only marginal underestimation of the time periods,thereby improving economic viability.Furthermore,the correct order of the first three vibration modes was effectively distinguished. 展开更多
关键词 fundamental time period formulas shear-wall multistory buildings seismic codes finite element modal analysis regression analysis
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阿尔贝蒂《论密码》中“formula”涵义与其密码算法 认领 引用
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作者 杨欣童 《计算》 CAS 2026年第2期62-67,72,共6页
阿尔贝蒂在其著作《论密码》中提出的核心概念“formula”,长期以来被解读为一种物理装置,即密码盘本身。然而,通过对《论密码》文本的细致分析及其密码算法的系统梳理,本文指出,这一传统理解未能充分揭示阿尔贝蒂的真实意图。研究表明,... 阿尔贝蒂在其著作《论密码》中提出的核心概念“formula”,长期以来被解读为一种物理装置,即密码盘本身。然而,通过对《论密码》文本的细致分析及其密码算法的系统梳理,本文指出,这一传统理解未能充分揭示阿尔贝蒂的真实意图。研究表明,“formula”并非仅指代密码盘的硬件结构,而是一个具有多种映射关系和多层映射关系的密码算法。该算法通过动态调整字母与数字的对应关系,实现了加密过程的复杂性与安全性,体现了阿尔贝蒂对数学映射思想的深刻运用。本文通过探求“formula”的涵义对阿尔贝蒂的密码装置与相应算法做了澄清,为西方密码学的机械化和算法化进程提供了参考。 展开更多
关键词 《论密码》 阿尔贝蒂 密码算法 formula 映射
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Some Reciprocity Formulas for Generalized Dedekind-Rademacher Sums 认领 引用
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作者 HE Yuan SHI Yongguo 《数学进展》 CSCD 北大核心 2026年第1期85-102,共18页
In this paper,we study the generalized Dedekind Rademacher sums considered by Hall,Wilson and Zagier.We establish a new formula for the products of two Bernoulli functions by using Parseval's formula,Hurwitz's... In this paper,we study the generalized Dedekind Rademacher sums considered by Hall,Wilson and Zagier.We establish a new formula for the products of two Bernoulli functions by using Parseval's formula,Hurwitz's formula and Lerch's functional equation.As applications of the result,some well-known reciprocity formulas are deduced as special cases. 展开更多
关键词 Bernoulli function Dedekind sum Hurwitz and Lerch zeta function reciprocity formula
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Yang Mai Tong Luo formula ameliorates heart failure with preserved ejection fraction by alleviating microvascular endothelial inflammation 认领 引用
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作者 Liting Huang Xingming Zhong +10 位作者 Longwei Yang Hongjing You Shengtao Xiong Ke Wang Lanting Fu Hecai Wang Liang Long Yunting Wang Haiyan Li Qiuhe Chen Yang Chen 《World Journal of Integrated Traditional and Western Medicine》 2026年第1期66-83,共18页
Objectives:The study aimed to investigate the efficacy and underlying mechanisms of Yang Mai Tong Luo formula(YMTLF)in the treatment of heart failure with preserved ejection fraction(HFpEF)by focusing on its ability t... Objectives:The study aimed to investigate the efficacy and underlying mechanisms of Yang Mai Tong Luo formula(YMTLF)in the treatment of heart failure with preserved ejection fraction(HFpEF)by focusing on its ability to alleviate microvascular endothelial inflammation.Methods:We analyzed the main components of YMTLF using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).An HFpEF mouse model was established using high-fat diet and N-nitro-L-arginine methyl ester(L-NAME)stimulation and then treated with YMTLF for 10 weeks.Cardiac function of mice was assessed by echocardiography.Myocardial cross-sectional area was evaluated by wheat germ agglutinin(WGA)staining.The blood perfusion of hindlimb was analyzed by laser speckle.Network pharmacology and transcriptome analysis were employed to explore the potential mechanisms of YMTLF in addressing HFpEF.Immunofluorescence staining was used to analyze the expression levels of proteins related to microvascular inflammation.Results:A total of 27 principal components of YMTLF were characterized by UPLC-MS/MS.YMTLF reversed the body mass gain,improved heart function and myocardial hypertrophy of HFpEF mice.Specifically,YMTLF treatment reduced serum N-terminal probrain natriuretic peptide(NT-proBNP)levels from 622 to 319 pg/mL and decreased left ventricular posterior wall thickness in diastole(LVPWD)from 0.794 to 0.604 mm(P<0.05).Furthermore,it improved hindlimb blood perfusion(perfusion unit value increased from 156 to 226).It ameliorated the microvascular endothelial dysfunction(zonula occludens-1,intercellular adhesion molecule-1 and vascular cell adhesion molecule-1)and downregulated the expression levels of microvascular inflammation related proteins(interleukin-1β,F4/80,high mobility group box 1,transforming growth factor β1 and thrombospondin-1)(P<0.05).Conclusions:YMTLF exerted a therapeutic effect on HFpEF by ameliorating microvascular inflammation. 展开更多
关键词 Yang Mai Tong Luo formula(YMTLF) heart failure with preserved ejection fraction(HFpEF) vascular endothelial dysfunction inflammation transforming growth factorβ(TGF-β)
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Tangwang formula ameliorates diabetic retinopathy by inhibiting cell apoptosis and regulating the intestinal microbiota and metabolic profiles 认领 引用
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作者 He Zhang Jia-Xin Xing +15 位作者 Yi-Fei Yin Jun Li Chen-Xu Jing Song-Yan Liu Jin-Zhu Yin Xiang Gao Zu-Guo Liang Tong-Yi Yuan Hang Su Ying-Qian Li Ze-Yu Wang Hai-Si Dong Da-Qing Zhao Da-Shi Ying Zhen-Wei Zhou Qing-Xia Huang 《World Journal of Diabetes》 SCIE 2026年第6期152-180,共29页
BACKGROUND Tangwang formula(TWF),a traditional Chinese medicine,has been shown to delay the progression of diabetic retinopathy(DR)over the past 20 years.However,the potential therapeutic mechanisms and effective comp... BACKGROUND Tangwang formula(TWF),a traditional Chinese medicine,has been shown to delay the progression of diabetic retinopathy(DR)over the past 20 years.However,the potential therapeutic mechanisms and effective components of TWF remain unclear.AIM To investigate the effective components of TWF and elucidate the mechanism underlying TWF treatment for DR.METHODS The chemical ingredients of TWF were detected using high-pressure liquid chromatography.Network pharmacology and molecular docking were applied to identify the targets and pathways associated with TWF and DR.A DR mouse model was established by streptozotocin to evaluate the therapeutic effect of TWF in vivo.High glucose treatment was used to induce injury in mouse retinal endothelial cells(mRECs)to verify the mechanism of TWF in vitro.The 16S ribosomal RNA sequencing and untargeted metabolomics were performed to detect intestinal bacteria and fecal metabolites in DR mice.RESULTS Eight important active constituents were identified by high-pressure liquid chromatography.Network pharmacology results showed that Bcl2 and Casp3 were key targets between TWF and DR.Isorhamnetin-3-O-neohespeidoside,naringenin,ononin,and calycosin-7-O-β-D-glucoside from TWF had strong affinities with Bcl2 and Casp3.TWF significantly reduced random blood glucose,inhibited the levels of proinflammatory factors in DR mice and mRECs,and alleviated retinal damage by downregulating the expressions of vascular endothelial growth factor and receptor advanced glycation end products,and upregulating the expressions of zonula occludens-1 and RBP-3.TWF inhibited the apoptosis in mouse retinal tissues and mRECs.Analysis of intestinal bacteria and metabolites revealed that TWF increased the richness and evenness of intestinal microbiota and improved fecal metabolic profiles in DR mice.Importantly,seven genus bacteria were closely correlated with amino acids,fatty acids,glycerophosphocholine,and bile acid,which could participate in ameliorating retinal injury.CONCLUSION These findings suggest that TWF may ameliorate retinal damage in DR mice via anti-inflammatory and antiapoptotic activities,which may be associated with modulation of the intestinal microbiota and metabolic profiles. 展开更多
关键词 Tangwang formula Diabetic retinopathy Cell apoptosis Intestinal bacteria Metabolic profiles
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