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Clinical and Epidemiological Analysis of 188 Hospitalized Pertussis Cases in Jingzhou City 认领 引用
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作者 Hongying WU Yu YANG Feiyu HUANG 《Asian Agricultural Research》 2026年第1期61-64,共4页
[Objectives]To analyze the clinical symptoms and epidemiological characteristics of 188 hospitalized pertussis cases in Jingzhou City.[Methods]Clinical data from 188 patients diagnosed with pertussis and admitted to t... [Objectives]To analyze the clinical symptoms and epidemiological characteristics of 188 hospitalized pertussis cases in Jingzhou City.[Methods]Clinical data from 188 patients diagnosed with pertussis and admitted to two tertiary hospitals in Jingzhou City between March and August 2024 were collected.Patients were randomly divided into three groups:<3-year-old,3—17-year-old,and≥18-year-old.A retrospective analysis was performed on their clinical features(including laboratory findings,disease course,and imaging characteristics)and epidemiological characteristics.[Results]In the<3-year-old group,28 cases(36.4%)were unvaccinated and 22 cases(28.6%)had received only one dose of the pertussis vaccine.In the 3—17-year-old group,91 cases(94.8%)had received four doses.Vaccination history was unknown for the≥18-year-old adult group.The<3-year-old group exhibited significantly higher incidences of cough with wheezing/dyspnea,paroxysmal spasmodic cough,cough with cyanosis or facial flushing,wheezes,and moist rales in the lungs compared to both the 3—17-year-old and≥18-year-old groups.Post-tussive vomiting was less frequent in the<3-year-old group than in the 3—17-year-old group but more frequent than in the≥18-year-old group;these differences were statistically significant(P<0.05).The≥18-year-old group had significantly lower incidences of cough with wheezing/dyspnea,paroxysmal spasmodic cough,cough with cyanosis or facial flushing,wheezes,and moist rales in the lungs compared to both the<3-year-old and 3—17-year-old groups(P<0.05).The proportion of cases with pneumonia and increased lung markings was higher in the<3-year-old group than in the 3—17-year-old group but lower than in the≥18-year-old group,showing statistically significant differences(P<0.05).The proportion of cases with pulmonary nodules and fibrotic foci was lower in the<3-year-old group than in both the 3—17-year-old and≥18-year-old groups,and these differences were also statistically significant(P<0.05).The proportion of pneumonia cases in the 3—17-year-old group was lower than in both the<3-year-old and≥18-year-old groups.The proportion of cases with increased lung markings was lower than in the<3-year-old group but higher than in the≥18-year-old group;these differences were statistically significant(P<0.05).The proportion of cases with pulmonary nodules and fibrotic foci in the 3—17-year-old group was higher than in the<3-year-old group but lower than in the≥18-year-old group,with statistically significant differences(P<0.05).The proportion of cases with pulmonary nodules and fibrotic foci was higher in the≥18-year-old group than in both the<3-year-old and 3—17-year-old groups,and these differences were also statistically significant(P<0.05).[Conclusions]Analysis of the clinical symptoms and epidemiological characteristics of 188 hospitalized pertussis cases in Jingzhou City contributes to enhancing the prevention and control of pertussis within the city. 展开更多
关键词 Pertussis Epidemiological characteristics Clinical features Imaging examination
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Risk factors for pertussis among children hospitalized for pertussis during 2016-2017, in Guizhou Province of China: a case-control study 认领 引用 被引量：4
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作者 Feng Jiang Keli Li +1 位作者 Guangpeng Tang Yan Huang 《Global Health Journal》 2021年第2期97-101,共5页
Aim:Pertussis is a respiratory tract infection,the vaccine for which was introduced in the Expanded Programme on Immunization(EPI)in Guizhou Province of China(hereafter referred as Guizhou)in the 1980s.This vaccine ra... Aim:Pertussis is a respiratory tract infection,the vaccine for which was introduced in the Expanded Programme on Immunization(EPI)in Guizhou Province of China(hereafter referred as Guizhou)in the 1980s.This vaccine rapidly decreased incidence rates of pertussis in the province,however,despite the wide high coverage of the diphtheria,tetanus and acellular pertussis(DTaP)combined vaccine,there has been a resurgence of pertussis since 2014.Even with this recent increase in disease transmission,risk factors for pertussis infection have not been evaluated in Guizhou.We aimed to provide information on pertussis risk factors and insight on designing targeted pertussis control policies and measures through this study.Methods:A 1:2 matched retrospective case-control study was conducted between 2016 and 2017,involving infants and children younger than 6 years old and parents of the participants.The enrolled cases included clinical and laboratory confirmed pertussis cases according to the WHO-recommended pertussis definition.Controls were selected from children in the same neighborhood who were not diagnosed with pertussis prior to our investigation and did not exhibit any clinical manifestations of pertussis.Results:The household size[Matched odds ratio(ORm=1.4,95%confidence interval(Cl):1.1-1.7]and household members with antecedent cough(ORm=3.6,95%CI:1.8-7.2)were significantly associated with their child’s pertussis onset.The parents’occupations were significantly associated with their child’s pertussis onset(ORm=9.4,95%CI:1.6-54.8,for mother side;ORm=4.5,95%CI:1.2-16.5,for father side),when they worked in the business and/or service industry.Having family members with a history of cough was an independent risk factor for pertussis[Adjusted odds ratio(AOR)=43.6,95%CI:2.7-694.0].Besides,the parents’demographic characteristics and DTaP doses were not found to be independent factors.Conclusion:Household exposure is an important risk factor for pertussis infection in infants and young children and should therefore be considered as a major factor during formulation of pertussis control policies and measures. 展开更多
关键词 Pertussis risk factors Household exposure Guizhou province China Pertussis resurgence Diphtheria Tetanus and acellular pertussis combined vaccine
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Seroepidemiological Assessment of Bordetella pertussis in Jahrom,Southern Iran:A Cross-Sectional Study 认领 引用
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作者 Rahim Raufi Fatemeh Zareian-Jahromi +2 位作者 Saba Zangeneh Jalil Rajabi Reza Shahriarirad 《Health Care Science》 CSCD 2025年第1期44-51,共8页
Background:Bordetella pertussis,the causative agent of whooping cough,is a significant contributor to recurrent persistent cough across all age groups,including vaccinated individuals.This seroepidemiological study ai... Background:Bordetella pertussis,the causative agent of whooping cough,is a significant contributor to recurrent persistent cough across all age groups,including vaccinated individuals.This seroepidemiological study aims to address the gap in understanding pertussis incidence by investigating its occurrence in individuals with persistent cough and describing the characteristics of affected patients admitted to clinical centers in Jahrom,Southwest Iran.Methods:This cross-sectional study enrolled 110 patients with a cough persisting for at least 2 weeks,admitted to clinical centers in Jahrom,Iran.Blood samples were collected at baseline and on day 21 of follow-up.Serum samples were analyzed for anti-pertussis toxin immunoglobulin G(anti-PT-IgG)levels using an enzyme-linked immunosorbent assay.Demographic factors,including age,gender,occupation,area of residence,and family size,were also evaluated.Results:Among the 110 participants,77(70%)were female,and seven patients(6.4%)tested seropositive for anti-PT-IgG.No significant associations were observed between pertussis incidence and the analyzed variables,including age,gender,occupation,area of residence(urban vs.rural),and family size(p>0.05).These findings underscore the importance of enhancing vaccination coverage to reduce the prevalence of B.pertussis in the community.Conclusion:This study highlights the occurrence of pertussis in individuals presenting solely with a persistent cough,absent of classic symptoms.The findings emphasize the need for healthcare providers to conduct detailed assessments and utilize rapid diagnostic methods for timely detection.This is particularly crucial in regions with high vaccination rates but limited awareness of pertussis recurrence. 展开更多
关键词 Bordetella pertussis Iran seroepidemiology
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Hyperleukocytosis associated with pertussis:Two case reports 认领 引用
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作者 Hong-Wu Han Xi-Xia Wang +1 位作者 Ying Wang Wei-Hua Zhang 《World Journal of Clinical Cases》 2025年第17期51-58,共8页
BACKGROUND Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis.Although the diphtheria-pertussis-tetanus vaccine is widely administered,there are still a number of patients with severe ... BACKGROUND Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis.Although the diphtheria-pertussis-tetanus vaccine is widely administered,there are still a number of patients with severe pertussis each year,which can lead to death,especially in infants and young children.Hyperleukocytosis is a factor related to the severity of pertussis and a risk factor for death.Reducing the leukocyte number by plasma exchange is a treatment method in clinical practice.CASE SUMMARY Two children with pertussis with cough as the initial symptom,developed pneumonia during the course of the illness.White blood cell counts were significantly increased with the highest values of 87.34×109/L and 55.46×109/L.Following anti-infection,plasma exchange,and ventilator treatment,both children recovered.CONCLUSION Early identification of children with pertussis complicated with hyperleukocytosis and timely plasma exchange can improve the prognosis and reduce mortality. 展开更多
关键词 Pertussis Hyperleukocytosis Plasma exchange Children Case report
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Antibody Levels and Infection Status of Pertussis in the Population under Pertussis Resurgence in Guangxi in 2018:A Cross-Sectional Survey 认领 引用 被引量：3
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作者 Liang Liang Qiuyun Deng +6 位作者 Lili Deng Jinghang Wei Shiyi Chen Yizhi Wei Yuyan Ma Yue Qin Wei Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第6期628-638,共11页
Objective Pertussis cases have increased markedly since 2018 in Guangxi.The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.Method A total of 10,215 s... Objective Pertussis cases have increased markedly since 2018 in Guangxi.The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.Method A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay(ELISA).Results Of the collected samples,1,833(17.94%)tested positive for anti-pertussis IgG,with the median concentration of 16.06 IU/mL.Antibody level<10 IU/mL accounted for more than 60%in children under 4 years of age,but declined with age,whereas the percentages of the other three levels(10-40,40-50,and≥50 IU/mL)increased almost with age(P<0.001).Moreover,7,924 samples were selected for anti-pertussis toxin IgG,of which 653(8.24%)tested positive(≥40 IU/mL)with the median concentration of 5.89 IU/mL,and 204 participants(2.56%)had recent pertussis infection(≥100 IU/mL).Among the different age groups,the highest rates of positivity and recent infection were observed at 11-20 years of age,the lowest positivity rate at 5 years of age,and the lowest recent infection rate at 4 years of age(P<0.001,P=0.005,respectively).Conclusion The survey results showed that all age groups in Guangxi lacked immunity against pertussis,which was one of the main factors contributing to the resurgence of pertussis in 2018.In addition,the prevalence of pertussis is relatively high in Guangxi,and its incidence is seriously underestimated,especially in adolescents and adults. 展开更多
关键词 Pertussis resurgence Anti-pertussis IgG Anti-pertussis toxin IgG Antibody level Infection status
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Epidemiological Characteristics and Risk Factors of the Pertussis in Infants < 12 Months of Age in Tianjin, China 认领 引用 被引量：10
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作者 HUANG Hai Tao GAO Zhi Gang +3 位作者 LIU Yong WANG Li Juan LIU Yan Ping ZHANG Ying 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第7期545-548,共4页
The epidemiologic characteristics of 631 infant pertussis cases 〈 12 months, which accounted for 57.42% of the total cases, were analyzed by descriptive epidemiology in Tianjin, between 2010 and 2015. The incidence o... The epidemiologic characteristics of 631 infant pertussis cases 〈 12 months, which accounted for 57.42% of the total cases, were analyzed by descriptive epidemiology in Tianjin, between 2010 and 2015. The incidence of infants was 104.66/100,000, which was 118 times higher than in other age groups （P 〈 0.001）. The primary type of pertussis simultaneously presented in households was adult-to-infant （70.51%）. The parents were identified as the source of infection in 80.18% of cases for infants. The positive rate of placental antibody transfer was 31.06% and 3.13% for 3-month-old infants. Infants presented the highest age-specific pertussis incidence. The most important reason was parents were the important sources of infection, and secondly the lower level of antibodies in neonates and the rapid waning of maternal antibody titer. 展开更多
关键词 of is In for were Months of Age in Tianjin China Epidemiological Characteristics and Risk Factors of the Pertussis in Infants
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Aberration detection of pertussis from the Mazandaran province, Iran, from 2012 to 2018: Application of discrete wavelet transform 认领 引用
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作者 Yousef Alimohamadi Seyed Mohsen Zahraei +3 位作者 Manoochehr Karami Mehdi Yaseri MojtabaLotfizad Kourosh Holakouie-Naieni 《Journal of Acute Disease》 2020年第3期114-120,共7页
Objective:To define the level of alarm threshold for pertussisaberrations and to detect the aberrations of the reported suspectedcases of pertussis from the Mazandaran province in the north ofIran.Methods:The included... Objective:To define the level of alarm threshold for pertussisaberrations and to detect the aberrations of the reported suspectedcases of pertussis from the Mazandaran province in the north ofIran.Methods:The included cases were composed of the suspectedpertussis patients who came from Mazandaran province andregistered in the Center for Disease Control and Prevention from20 March 2012 to 20 March 2018.A discrete wavelet transformbasedmethod was used to detect the aberrations.All analyseswere performed using MATLAB Software version 2018a andExcel 2010.Results:A total of 1162 cases were recruited in the study,including 545(46.90%)males and 617(53.10%)females,withmedian age of 1.47(0.22-9.56)years.The median age of maleswas 1.18(0.21-8.24)years,while that of females was 1.82(0.21-10.75)years.Concerning the level of the alarm threshold,it was1.28 case/d when k=2,while it was 1.34 case/d when k=3.Thetotal detected aberration days were 123 d and 57 d by consideringk=2 and 3,respectively.The most defined alarm threshold wasrelated to spring(>2 cases/d)and summer(>1 case/d),respectively.Conclusions:The sensitivity of the surveillance system issubjected to a different time.Thus,determining the level of alarmthreshold periodically using different methods is recommended. 展开更多
关键词 Aberration detection Pertussis Mazandaran Iran Discrete wavelet transform
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30 and 32 kDa outer membrane proteins of Bordetella pertussis as a modulator on promoting degranulation of mast cells 认领 引用
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作者 YONG LIANG LOU JIE YAN +1 位作者 YI HUI LUO YA FEI MAO 《Journal of Microbiology and Immunology》 2005年第2期111-119,共9页
The correlation between the activities of the outer menbrane proteins （OMPs） of Bordetella pertussis and the lgE-mediated asthma was investigated in the present study, in which the OMPs of B. pertussis and their com... The correlation between the activities of the outer menbrane proteins （OMPs） of Bordetella pertussis and the lgE-mediated asthma was investigated in the present study, in which the OMPs of B. pertussis and their components were prepared by detergent treatment and chromatography, and the molecular weights of the OMPs components were determined by SDS-PAGE. The amounts of total as well as the ovalbumin （OVA）-specific IgE induced by dead B. pertussis whole bacterial vaccine on guinea pigs were detected by ELISA. Meanwhile, the effect of the OMPs and their components to promote the degranulation of guinea pig mast cells was observed by using the mast cell degranulation test, and ELISA assay was used to measure the histatmine levels in the supematants from the mast cell cultures. Histamine sensitive test was used to demonstrate the effects of the OMPs and their components to increase the histamine lethal sensitivity in mice. It was found that four components with molecular weights of 30, 32, 38 and 69 kDa could be obtained from the OMPs of B. pertussts, and the dead whole bacteria vaccine of B. pertussis had the ability to increase the levels of the total as well as the OVA-specific IgE in sera of guinea pigs. The OMPs and their 30 and 32 kDa components demonstrated significantly enhancing effect on the degranulation of guinea pig mast cells, and the histamine levels in the supematants from the mast cell culture treated with OMPs and their 30 and 32 kDa components were also significantly increased. It is evident that the strong adjuvant activity and the enhancing effect to degranulation of mast cells and the release of histamine of certain outer membrane components of B. pertussis could be demonstrated as revealed by the results of the present study, suggesting the possibility of a close relationship between the infection of vaccination with B. pertussis and the IgE-mediated asthma. 展开更多
关键词 Bordetella pertussis Bacterial outer membrane protein Immunoglobulin E Mast cells Cell degranulation Histamine Asthma
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Characterization of two Achromobacter xylosoxidans isolates from patients with pertussis-like symptoms 认领 引用
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作者 Fiorella Orellana-Peralta Michelle Jacinto +5 位作者 Maria J.Pons Cláudia Gomes Carlos Bada Isabel Reyes Juana del Valle Mendoza Joaquim Ruiz 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第6期465-468,共4页
Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year ... Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR.Results:Two Achromobaeter xylosoxidans A8,closely related to Bordetella spp.were recovered from 2 patients diagnosed of pertussis,both carrying the ptxA gene and IS418 the pertussis toxin encoding gene.Subsequently,antibiotic susceptibility was evaluated by disk-diffusion method and by PCR.Conclusions:Although more detailed studies are needed,the present data highlight the possibility that Achromobaeter xylosoxidans.closely related Bordetella pertussis microorganisms and not covered under the vaccine umbrella,might also result in cases of whooping cough.Thereby further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to discriminate their real public health implication. 展开更多
关键词 Achromobacter xylosoxidans Bordetella pertussis
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The First Reported Case of Co-Infection with Neisseria Meningitidis and Bordetella Pertussis in the Cerebrospinal Fluid Specimen of a Normal Four-Year-Old Child 认领 引用
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作者 XIA Xian LI Guo Ming +7 位作者 TANG Yi WANG Si Quan HE Fei JIANG Yong Zhong YANG Hong Mei JIANG Hong Lin LYU Jing MAO Ling Feng 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第4期432-435,共4页
Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(B.pertussis),which occurs in people of all ages and is most dangerous for young children,especially infants.The introducti... Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(B.pertussis),which occurs in people of all ages and is most dangerous for young children,especially infants.The introduction of whole-cell pertussis vaccines(wPVs)in the 1950s dramatically reduced the incidence of pertussis worldwide[1].However,over the past two decades,many studies have reported the resurgence of pertussis in different countries[2].Epidemiological surveillance in Hubei Province over the last 3 years revealed a clear increasing trend in the incidence of pertussis during the coronavirus disease 2019(COVID-19)epidemic. 展开更多
关键词 Pertussis dangerous Hubei
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Seroepidemiological study of pertussis in Henan Province,China,and prediction of the effectiveness of a new immunization strategy 认领 引用
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作者 Yuting Tang Qian Liu +3 位作者 Jiangnan Kong Daxing Feng Qiaohua Dou Yonghao Guo 《Biosafety and Health》 CSCD 2026年第1期42-50,共9页
The study objectives were to analyze the epidemiological characteristics of pertussis in Henan Province,China,and to evaluate the impact of pertussis vaccination strategy adjustments on population infection rates.A re... The study objectives were to analyze the epidemiological characteristics of pertussis in Henan Province,China,and to evaluate the impact of pertussis vaccination strategy adjustments on population infection rates.A retrospective analysis was conducted on the reported pertussis cases in Henan Province from 2012 to 2024.The concentration of IgG antibodies against pertussis toxin(anti-PT IgG)was measured in 18,528 healthy individuals from 2022 to 2024.The positive rate(≥20 IU/mL)and median concentration(MC)were calculated,and the infection rate was estimated based on anti-PT IgG≥40 IU/mL,using the susceptible-exposed-infec tious-recovered-vaccinated(SEIRV)model to predict the effect of adding a pertussis booster dose at 6 years.The average annual incidence of pertussis in Henan Province from 2012 to 2024 was 2.21 per 100,000 population.The overall anti-PT IgG positivity rate was 16.42%,and the MC was 4.66 IU/mL.The antibody concentration is influenced by age,gender,and vaccine type.The population that completed the full course of vaccination had the highest anti-PT IgG positive rate(17.81%)and the highest MC(4.97 IU/mL).The population that vaccinated the diphtheria-tetanus-acellular pertussis-inactivated polio vaccine-haemophilus influenzae type b(DTaP-IPV/Hib)had the highest MC(14.83 IU/mL).The total estimated infection rate of pertussis was 7,833.45 per 100,000,peaking in the 6-year age group(10,809.72 per 100,000).When the estimated coverage rate of the pertussis booster vaccination reaches 83.21%,the infection rate could be decreased by 71.41%.The incidence of pertussis in Henan Province has increased,and the infection rate is higher than anticipated.Booster immunization at age six can significantly lower the risk of infection. 展开更多
关键词 Pertussis Epidemiological characteristics Antibody concentration Immunization strategy Susceptible-exposed-infectious-recovered-vac cinated model(SEIRV)
Global,regional,and national burden of pertussis in children aged 0-14 years from 1990 to 2021:A systematic analysis of the Global Burden of Disease Study 2021 认领 引用
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作者 Yinsong Luo Xi Xiao +7 位作者 Yuxin Jiang Xiaorui Li Lingyun Ge Yiyao Hu Chenye Liu Dian Zhao Tianqi Kong Jiaye Liu 《Infectious Diseases & Immunity》 CSCD 2026年第2期111-121,共11页
Background:Despite widespread vaccination efforts,pertussis remains a significant global public health concern,particularly among children.This study aimed to assess the burden and temporal trends of pertussis globall... Background:Despite widespread vaccination efforts,pertussis remains a significant global public health concern,particularly among children.This study aimed to assess the burden and temporal trends of pertussis globally,regionally,and nationally by age,sex,and socio-demographic index(SDI)among children aged 0-14 years from 1990 to 2021,which is critical for informing targeted prevention strategies.Methods:We analyzed data from the Global Burden of Disease Study(GBD)2021 on pertussis incidence,disability-adjusted life years(DALYs),mortality,and years lived with disability.The estimated annual percentage changes(EAPCs)were calculated to quantify temporal trends.Joinpoint regression analysis was used to identify the points at which significant changes in the trend occurred.To update the temporal trend analyses beyond 2021,we also incorporated the most recent pertussis estimates for relevant countries and territories from the GBD 2023 dataset.Results:Globally,approximately 19.9 million new cases of pertussis were recorded among children aged 0-14 years(age-standardized incidence rate 1,022.1 per 100,000 population)and 11.9 million DALYs(age-standardized DALY rate 608.7 per 100,000 population)in 2019.The age-standardized incidence of pertussis decreased by an EAPC of 1.7 from 1990 to 2009 and by 1.3 from 2010 to 2019,and declined further by 2021,probably due to Coronavirus Disease 2019 control measures.However,this overall downward trend masked considerable regional variation.Between 2010 and 2019,11 out of 21 GBD regions experienced rising incidence,particularly in Tropical Latin America,Central Europe,and Central Latin America.Among high-SDI countries,pertussis incidence increased substantially in Cyprus(EAPC 17.62)and Finland(EAPC 19.66)from 2011 to 2019.In 2019,infants under 1 year old exhibited the highest pertussis incidence,and girls consistently had higher rates than boys across all age groups.In 2023,the highest age-standardized incidence was observed in the United States Virgin Islands among high SDI countries(1,597.5 per 100,000 population)and in Bosnia and Herzegovina among high-middle SDI countries(1,074.3 per 100,000 population).Conclusions:Although the age-standardized incidence and DALYs of pertussis have declined among children aged 0-14 since 1990,the disease has resurged in about half of the regions worldwide.Pertussis-related incidence and DALYs were higher in infants under 1 year old and girls.Maternal vaccination,continuous surveillance,and tailored public health interventions should be targeted toward vulnerable populations to prevent pertussis resurgence. 展开更多
关键词 Children Pertussis GBD 2021 Disease burden Temporal trend
Comparing frequentist and Bayesian methods to identify drivers of pathogen strain invasion:A temporal case study of pertussis in the United States 认领 引用
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作者 Florian Lecorvaisier Dominique Pontier +1 位作者 Frank Sauvage David Fouchet 《Infectious Disease Modelling》 CSCD 2026年第2期389-406,共18页
Since the 20th century,it has been widely recognized that the emergence of new pathogens is closely linked to human activities such as global travel and environmental exploitation.In addition,the widespread use of ant... Since the 20th century,it has been widely recognized that the emergence of new pathogens is closely linked to human activities such as global travel and environmental exploitation.In addition,the widespread use of antibiotics and vaccines has contributed to the evolution and dissemination of new pathogen variants.However,the role of environmental and socio-demographic cofactors on the dynamics of pathogen spread remains insufficiently explored.In this study,we argue that such influences are best captured using mixed logistic regression models that incorporate temporally autocorrelated random effects,in order to reflect the complex and time-dependent nature of strain invasion processes.To address the statistical challenges of this framework,we compared two approaches:(i)a simplified model with independent random effects and frequentist inference,and(ii)a full model accounting for temporal autocorrelation,estimated using Bayesian inference.Our results show that the simplified model,although commonly used in longitudinal analyses,substantially underestimates the probability of detecting false-positive associations(i.e.,it underestimates the Type I error rate),leading to potentially misleading conclusions.In contrast,the full Bayesian model avoids this bias and offers a more robust alternative.We applied this approach to a dataset monitoring the emergence of vaccine-escape Bordetella pertussis strains in the United States between 2007 and 2017.Among the eight cofactors tested,only temperature was significantly associated with the rate of strain invasion.Further simulation-based analyses revealed that the current dataset has limited statistical power to detect such associations.However,our results suggest that increasing the temporal resolution of data collection could substantially improve the model's ability to detect meaningful associations–without increasing surveillance costs. 展开更多
关键词 Bayesian methods frequentist methods pathogen strain invasion mixed logistic regression emergence new pathogens temporal autocorrelation global travel pertussis
Study on the resurgence of pertussis based on a stage-structured dynamic model 认领 引用
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作者 Yifei Qiao Jijun Zhao 《Infectious Disease Modelling》 CSCD 2026年第2期643-651,共9页
Although pertussis vaccination has effectively reduced the global incidence rate and mortality,pertussis resurgence has been observed in many countries in recent years.This study aims to untangle the changes in dynami... Although pertussis vaccination has effectively reduced the global incidence rate and mortality,pertussis resurgence has been observed in many countries in recent years.This study aims to untangle the changes in dynamic transmission characteristics before and after pertussis resurgence in high-incidence provinces of China and to explore the contributing factors and potential control measures.Shandong,Sichuan,and Zhejiang provinces were selected as study subjects.Based on monthly cases data from 2004 to 2022,dynamic models incorporating different waning immunity were constructed to identify the model that most appropriately reflected the epidemic dynamics in these provinces.From 2004 to 2013 in Shandong Province,and from 2004 to 2017 in Zhejiang and Sichuan Province,the Susceptible-Vaccinated-Infected-Recovered model(SVIR)best captured the epidemic dynamics in the three provinces,with an estimated vaccine protection duration of approximately 7–11 years.After the resurgence,the Susceptible-Vaccinated-Infected-Recovered-Susceptible model(SVIRS)more accurately represented the epidemic dynamics across the three provinces,with vaccine protection lasting 7–13 years and natural immunity persisting for 16–24 years,indicating the absence of lifelong immunity.Moreover,we found increases in the average transmission rate,case reporting,and vaccine effectiveness for pertussis.The observed resurgence of pertussis in the three provinces in China is affected by multiple factors,including elevated transmission rates,improved reporting rate,and vaccine-induced immunity waning.To mitigate resurgence,booster vaccination strategies targeting adolescents and adults should be considered. 展开更多
关键词 Pertussis resurgence Dynamic model Immunity duration Transmission rate
Research on pharmacological mechanism of the treatment of Asthma by oral Bordetella pertussis 认领 引用
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作者 CHI Shen SUN Yun ZHANG Bao-yuan 《沈阳药科大学学报》 CAS 北大核心 2008年第S1期115-116,共2页
Objective To examine the effect of oral Bordetella pertussis on the asthma mice sensitized by ovalbumin(OVA),and explore the possible mechanism.Methods Culture the B.pertussis in Bordet-Gengou agar containing 25%rabbi... Objective To examine the effect of oral Bordetella pertussis on the asthma mice sensitized by ovalbumin(OVA),and explore the possible mechanism.Methods Culture the B.pertussis in Bordet-Gengou agar containing 25%rabbit blood.Collect the bacteria and inactive them at 80℃for 30 min to get whole killed B.pertussis.32 BALB/C mice were randomly divided into control group,model-control group,model group and treatment group.The mice were sensitized and challenged with OVA to establish asthma model.Asthma mice in treatment group were orally administrated with B.pertussis 7 days before sensitization.The mice in control group and model-control group were challenged with saline.After 24 hours of last challenge,bronchoaveolar lavage fluid(BALF)and peripheral blood were collected.The total cells and eosinophils were counted in BALF.Results Compared with the control group(2.03±0.42,0.33±0.82)×105 mL-1 and model-control group(2.16±0.48,0.16±0.41)×105 mL-1,the total cells(10.13±1.33)×105 mL-1 and eosinophils(11.83±4.573)×105 mL-1 in BALF were more in asthma mice(P<0.01).The number of total cells(5.50±1.55)×105 mL-1 and eosinophils(0.66±0.82)×105 mL-1 in BALF were reduced in asthma mice treated with B.pertussis compared with asthma mice(P<0.01).Conclusions Oral B.pertussis can inhabit airway inflammation of asthma mice and has the potential of treating asthma. 展开更多
关键词 asthma airway inflammation Bordetella pertussis bral eosinophils
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Global,regional,and national burdens of pertussis among adults:a systematic analysis of age-specific trends using Global Burden of Diseases 2021 data 认领 引用
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作者 Kangguo Li Jiadong Wu +8 位作者 Ruixin Zhang Yulun Xie Zecheng Zhou Qi Yin Qi Chen Jia Rui Xuhua Guan Zeyu Zhao Tianmu Chen 《Infectious Diseases of Poverty》 SCIE CSCD 2025年第4期106-107,共2页
Background Despite the high coverage of childhood vaccination,pertussis remains a significant global health challenge,with increasing adult cases attributed to waning immunity and enhanced diagnostic capability.This s... Background Despite the high coverage of childhood vaccination,pertussis remains a significant global health challenge,with increasing adult cases attributed to waning immunity and enhanced diagnostic capability.This study quantified the global burden of pertussis in adults from 1990 to 2021 and evaluated the impact of the COVID-19 pandemic on disease trends.Methods Using data from the Global Burden of Disease Study 2021,we assessed pertussis incidence and disabilityadjusted life years(DALYs)in adults,stratified by age,sex,sociodemographic factors,and geographic regions.Temporal trends were analysed using joinpoint regression to detect significant changes and calculate the average annual percentage change(AAPC).An exponential smoothing state-space model with hierarchical forecast reconciliation was used to estimate the impact of the COVID-19 pandemic on pertussis burden.Results Globally,the incidence rate of adult pertussis declined from 17.44 per 100,000 population in 1990 to 9.00 per 100,000 in 2019,and fell sharply to 2.70 per 100,000 by 2021.DALYs rates followed a similar trend.The burden was consistently highest in low Socio-demographic Index(SDI)countries,where the 2019 incidence rate was over four times that of high SDI countries(18.59 vs.3.96 per 100,000).Between 1990 and 2019,incidence numbers increased in low SDI countries[AAPC:0.63%;95%confidence interval:0.36%,0.91%]and in older adults(AAPC>0),despite falling incidence rates.From 2009 to 2019,incidence rates increased in 84 countries.During the COVID-19 pandemic,estimates based on the model indicated a 58.41%reduction in incidence and a 50.34%decrease in DALYs.Conclusions Although the global incidence of adult pertussis has declined over the past three decades,a resurgence from 2009 to 2019,particularly in low-income regions and specific age groups,underscores the persistent challenges.The sharp decline during the COVID-19 pandemic highlights the importance of public health and social measures.These findings emphasise the need for targeted vaccination strategies and sustained surveillance to address regional disparities and prevent the resurgence of the disease. 展开更多
关键词 Pertussis Resurgence Adult Incidence Disability-adjusted life years
Clinical characteristics,molecular epidemiology and antimicrobial susceptibility of pertussis among children in southern China 认领 引用 被引量：16
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作者 Jiao-Sheng Zhang Hong-Mei Wang +4 位作者 Kai-Hu Yao Ying Liu Yan-Ling Lei Ji-Kui Deng Yong-Hong Yang 《World Journal of Pediatrics》 SCIE CSCD 2020年第2期185-192,共8页
Background Increasing numbers of pertussis cases have been reported in recent years.The reported cases from Shenzhen Children's Hospital were close to one tenth of all cases in China.The epidemiology of antigenic ... Background Increasing numbers of pertussis cases have been reported in recent years.The reported cases from Shenzhen Children's Hospital were close to one tenth of all cases in China.The epidemiology of antigenic genotype and antibiotic resistance of circulating strains in children have been unknown in Shenzhen,southern China.The aim of this study was to describe the clinical features and explore the genotypes and antimicrobial susceptibility of circulating Bordetella pertussis among children in Shenzhen.Methods Data of hospitalized children with pertussis in Shenzhen Children's Hospital from August 2015 to April 2017 were collected.The genetic variability of isolates was investigated and Etest was performed for phenotypic susceptibility to erythromycin,azithromycin,clarithromycin,clindamycin,and trimethoprim/sulfamethoxazole.Results 469 children with pertussis confirmed by real-time quantitative polymerase chain reaction were hospitalized and strains were isolated from 105 patients.White blood cell count≥20×10^9/L and lymphocyte proportion≥60%were observed in 39.29%of infants younger than 3 months.The two predominant profiles of virulence-associated allelic genes were ptxA1/ptxC1/ptxPl/prnl(48.6%)and ptxA1/ptxC2/ptxP3/prn2(44.8%).Among the isolates,48.6%(51/105)were found resistant to macrolides.Conclusions These findings indicate that leukocytosis is not a sensitive indicator of pertussis.Isolates with the gene profile ptxP3/prn2 were highly circulating in Shenzhen and less resistant to macrolides,different from patterns observed in other parts of China. 展开更多
关键词 Antimicrobial susceptibility Bordetella pertussis Children Genotype Virulence
Expert consensus for pertussis in children: new concepts in diagnosis and treatment 认领 引用 被引量：14
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作者 Yu-Mei Mi Ji-Kui Deng +22 位作者 Ting Zhang Qing Cao Chuan-Qing Wang Sheng Ye Ying-Hu Chen Han-Qing He Bei-Bei Wu Yan Liu Mei Zeng Wei Li Fang Wu Hong-Mei Xu Shi-Yong Zhao Gang Liu Wang Hua Dan Xu Guan-Nan Bai Ying Yang Li-Su Huang Yi-Ping Chen Kai-Hu Yao Zhu-Jun Shao Chun-Zhen Hua 《World Journal of Pediatrics》 SCIE CSCD 2024年第12期1209-1222,共14页
Background Pertussis resurgence has been reported worldwide in the past two decades. Pertussis is still endemic and diffcult to control though with universal vaccination in children. The resurgence may be related to m... Background Pertussis resurgence has been reported worldwide in the past two decades. Pertussis is still endemic and diffcult to control though with universal vaccination in children. The resurgence may be related to multiple variables, such as increased disease awareness and laboratory tests, waning of immunity following vaccination, and/or genetic mutations of Bordetella pertussis. For better pertussis prevention, diagnosis, and management, we called up an expert panel to develop this expert consensus to provide new concepts in diagnosis and treatment for clinical practice.Data sources The expert groups collected clinical evidence, summarized their clinical experiences, evaluated preliminary recommendations or guidelines, and then organized open-ended discussions to form the recommendations. This consensus was developed by reviewing the literature and studies in databases, including PubMed, Cochrane, EMBASE, the China Biomedical Database, and the Chinese Journal Full-text Database up to May 2024. The search terms included “pertussis” or “whooping cough”, “children”, “diagnosis”, and “treatment”.Results The burden of pertussis has also changed from infants to  school children and adults, and these age groups have consequently become the main source of infection for vulnerable population including infants and newborns. In China, a high prevalence of erythromycin-resistant Bordetella pertussis (ERBP) has been reported in the past decade. ERBP may lead to failed clinical empirical treatment with macrolides, which poses a great challenge for pertussis management and control. For better management of pertussis, a fow diagram for diagnosis and treatment of pertussis was presented in this consensus. This consensus also described the diagnostic criteria for pertussis, high-risk cases, and severe pertussis. Macrolides can still be used to treat confrmed erythromycin-sensitive B. pertussis (ESBP) infections, whereas oral trimethoprim–sulfamethoxazole therapy is the initial treatment option for children older than two months. For infants younger than two months, severe patients, or those exhibiting a high degree of sulfonamide allergy, intravenous administration of piperacillin or cefoperazone–sulbactam is advised.Conclusions This expert consensus provides a comprehensive guidance and a reference for the diagnosis and treatment of pertussis in children. 展开更多
关键词 Children Diagnosis Expert consensus Pertussis Treatment
Emergence of Erythromycin-Resistant and Pertactin-and Filamentous Hemagglutinin-Deficient Bordetella pertussis Strains—Beijing,China,2022-2023 认领 引用 被引量：15
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作者 Guilan Zhou Ying Li +7 位作者 Hairui Wang Yuanyuan Wang Yuan Gao Juan Xu Fengshuang Wang Tao Peng Maojun Zhang Zhujun Shao 《China CDC weekly》 SCIE CSCD 2024年第20期437-441,共5页
What is already known about this topic?Pertussis has reemerged as a significant public health threat,primarily due to variations in Bordetella pertussis strains,antimicrobial resistance,and vaccine evasion.What is add... What is already known about this topic?Pertussis has reemerged as a significant public health threat,primarily due to variations in Bordetella pertussis strains,antimicrobial resistance,and vaccine evasion.What is added by this report?All isolated strains were identified as ptxA1/ptxC2/ptxP3/prn150/fim2-1/fim3-1/fhaB1cfA2 type and exhibited resistance to erythromycin. 展开更多
关键词 vaccine pertussis primarily
Resurgence of pertussis:reasons and coping strategies 认领 引用 被引量：24
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作者 Chun-Zhen Hua Han-Qing He Qiang Shu 《World Journal of Pediatrics》 SCIE CSCD 2024年第7期639-642,共4页
Pertussis(whooping cough)is an acute and contagious respiratory disease caused by the pathogen Bordetella pertussis(B.pertussis).B.pertussis can infect individuals of all ages.Children with pertussis may experience se... Pertussis(whooping cough)is an acute and contagious respiratory disease caused by the pathogen Bordetella pertussis(B.pertussis).B.pertussis can infect individuals of all ages.Children with pertussis may experience severe and persistent coughing and paroxysms;for newborns and infants,pertussis may be life-threatening.The development and widespread administration of the pertussis vaccine had once successfully brought pertussis under control,maintaining it at a low level for many years.However,resurgence of pertussis has been reported in many countries even with high vaccination coverage recently.The resurgence of pertussis was first reported in the United States(USA)in 1993[1].During 2000–2016,the baseline incidence increased and the age distribution of pertussis changed in the USA[2].Other countries including Canada[3],Australia[4],European Union countries,and South Korea have also reported a rise in pertussis outbreaks[2,5]. 展开更多
关键词 pertussis Canada surge
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