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Fault Diagnosis Based on BA-SVM Trapezoidal Region Pole Classification 认领 引用
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作者 DU Zi-wei YAO Bo WANG Fu-zhong 《Chinese Quarterly Journal of Mathematics》 2026年第2期197-206,共10页
For a class of linear constant systems, the problem of continuous gain type fault diagnosis and reliable control of a single component of an actuator is investigated based on the trapezoidal region. Firstly, in order ... For a class of linear constant systems, the problem of continuous gain type fault diagnosis and reliable control of a single component of an actuator is investigated based on the trapezoidal region. Firstly, in order to solve the problem that the pole information of closed-loop system is difficult to observe, a design scheme of full-dimensional state observer is given to realize the real-time observation of pole information and form a pole classification database for system failure. Secondly, according to the characteristics that the poles are located in different areas when different channels have faults, support vector machine is applied to design a pole classifier to diagnose faults in the system and achieve accurate and reliable control of the system based on the fault diagnosis results.Then, in order to solve the problem of difficulty in selecting parameters for support vector machines, the bat algorithm(BA) is proposed to achieve automatic parameter optimization, which has the advantages of strong robustness and easy to combine with other methods. 展开更多
关键词 Pole classifier Support vector machine Bat algorithm Regional pole assignment Fault diagnosis
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Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques 认领 引用
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作者 Qinyao Sun Shunli Zhu +6 位作者 Futing Yang Zhigang Chen Heling Li Heng Shao Hong Wang Sangma Xie Jiaojian Wang 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期91-106,共16页
The temporal pole(TP),one of the most expanded cortical regions in humans relative to other primates,plays a crucial role in human language processing.It is also one of the most structurally and functionally asymmetri... The temporal pole(TP),one of the most expanded cortical regions in humans relative to other primates,plays a crucial role in human language processing.It is also one of the most structurally and functionally asymmetric regions.However,whether the functional architecture of the TP is shared by humans and macaques is an open question.We used spectral clustering algorithms to define a cross-species fine-grained TP atlas with different anatomical connectivity patterns.We identified three similar subregions,two ventral and one dorsal,within the TP in both humans and macaques.The parcellation scheme for the TP was validated using functional gradient mapping,anatomical connectivity and resting-state functional connectivity pattern analysis,and functional characterization.Furthermore,in conjunction with the Allen Human Brain Atlas,we revealed the molecular basis for the functional connectivity patterns of each human TP subregion.In addition,we compared the hemispheric asymmetry in mean gray matter volume,anatomical connectivity fingerprints,and whole brain functional connectivity patterns to reveal the evolutionary differences in the TP and found different asymmetric patterns between humans and macaques.In conclusion,our findings reveal that the asymmetry in structure and connectivity may underpin the hemispheric functional specialization of the brain and provide a novel insight into understanding the evolutionary origin of the TP. 展开更多
关键词 Temporal pole Parcellation Asymmetry Evolution Human Macaque
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恩沃利单抗治疗POLE突变型局部进展期直肠癌临床完全缓解1例 认领 引用
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作者 葛郁平 高鑫 +1 位作者 孙昭 周建凤 《基础医学与临床》 CAS 2026年第8期1126-1129,共4页
目的探讨携带POLE校对缺陷突变的局部进展期直肠癌患者治疗策略。方法分析1例POLE p.V411L突变型局部进展期直肠癌患者的临床资料。结果本例系41岁错配修复功能完整的局部进展期直肠癌男性患者,初始接受新辅助同步放射和化学治疗,腹腔... 目的探讨携带POLE校对缺陷突变的局部进展期直肠癌患者治疗策略。方法分析1例POLE p.V411L突变型局部进展期直肠癌患者的临床资料。结果本例系41岁错配修复功能完整的局部进展期直肠癌男性患者,初始接受新辅助同步放射和化学治疗,腹腔镜探查发现肿瘤无法根治性切除,后基因检测提示POLE校对缺陷突变、肿瘤突变负荷426 mut/MB,患者接受2年恩沃利单抗治疗,临床达到长期完全缓解。结论POLE校对缺陷突变的结直肠癌对免疫治疗高度敏感;对于侵犯周围组织或器官,或手术涉及器官功能保留的直肠癌应考虑基因检测,筛查有无POLE校对缺陷突变等,从而获得最佳疗效。 展开更多
关键词 直肠癌 POLE突变 免疫治疗 完全缓解
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POLE基因的研究进展 认领 引用
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作者 袁会军 马倩国 +3 位作者 郭兴才 郝志成 马福慧 杨勇 《四川医学》 CAS 2026年第2期212-216,共5页
肿瘤微环境(TME)是肿瘤发展和治疗反应的重要因素,其中包含肿瘤细胞、基质细胞、免疫细胞以及各种细胞外基质成分。TME中的免疫细胞如树突状细胞、T细胞和巨噬细胞等在肿瘤的发生和进展中发挥着复杂的作用。在某些肿瘤中,免疫抑制性微... 肿瘤微环境(TME)是肿瘤发展和治疗反应的重要因素,其中包含肿瘤细胞、基质细胞、免疫细胞以及各种细胞外基质成分。TME中的免疫细胞如树突状细胞、T细胞和巨噬细胞等在肿瘤的发生和进展中发挥着复杂的作用。在某些肿瘤中,免疫抑制性微环境的形成可以导致肿瘤细胞逃避免疫监视,从而促进肿瘤的生长和转移[1]。与此相对,肿瘤免疫治疗的目标就是通过重塑这一微环境来增强机体的抗肿瘤免疫反应。 展开更多
关键词 POLE 子宫内膜癌 结直肠癌 非小细胞肺癌 胶质母细胞瘤
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POLE基因变异致IMAGe综合征临床及遗传学分析 认领 引用
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作者 张利明 潘桂梅 +2 位作者 高静 杨俊梅 陈永兴 《中国优生与遗传杂志》 2026年第7期1441-1444,共4页
目的探讨1例IMAGe综合征患儿的临床特征及基因变异特点。方法回顾性分析2025年5月郑州大学附属儿童医院内分泌遗传代谢科收治的1例IMAGe综合征患儿的临床资料及基因检测结果。结果患儿,男,5岁4月龄,存在特殊面容、宫内及生后生长迟缓、... 目的探讨1例IMAGe综合征患儿的临床特征及基因变异特点。方法回顾性分析2025年5月郑州大学附属儿童医院内分泌遗传代谢科收治的1例IMAGe综合征患儿的临床资料及基因检测结果。结果患儿,男,5岁4月龄,存在特殊面容、宫内及生后生长迟缓、身材矮小、垂体前叶功能低下、甲状腺机能减退、生殖器畸形。拷贝数分析提示患儿染色体10q26.3区域存在约38.68 kb的重复:seq[GRCh37]dup(10)(q26.3)chr10:135340356_135379033dup;全外显子组测序显示POLE基因携带c.3989C>T(p.P1330L)和c.720+5G>C复合杂合变异,2种变异分别源自父亲、母亲,均为未报道新变异。根据ACMG指南,c.3989C>T(p.P1330L)变异被评级为可能致病变异(PM2_supporting+PM3+PP1+PP3+PP4),c.720+5G>C变异被评级为致病变异(PVS1+PM2_supporting+PP1+PP3+PP4)。结论IMAGe综合征临床罕见,POLE基因c.3989C>T(p.P1330L)和c.720+5G>C复合杂合变异考虑为本研究患儿的遗传学病因。 展开更多
关键词 IMAGe综合征 POLE基因 全外显子组测序
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POLEmut型子宫内膜癌/子宫内膜非典型增生保留生育功能治疗13例病例分析 认领 引用
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作者 任倩 张立娟 +12 位作者 薛誉 卢丹华 王伟娜 刘春红 王一飞 符元元 孙月芳 姬果 黄琼漪 郑佳谊 朱慧庭 单伟伟 陈晓军 《中国妇产科临床杂志》 CSCD 北大核心 2026年第2期99-104,共6页
目的探讨POLE超突变型(POLEmut)子宫内膜癌(EC)/子宫内膜非典型增生(EAH)患者保留生育功能治疗(FST)的疗效,对比孕激素/促性腺激素释放激素激动剂(GnRH-a)与免疫检查点抑制剂(ICIs)方案的疗效差异。方法回顾性收集2019年4月至2025年11... 目的探讨POLE超突变型(POLEmut)子宫内膜癌(EC)/子宫内膜非典型增生(EAH)患者保留生育功能治疗(FST)的疗效,对比孕激素/促性腺激素释放激素激动剂(GnRH-a)与免疫检查点抑制剂(ICIs)方案的疗效差异。方法回顾性收集2019年4月至2025年11月在复旦大学附属妇产科医院和同济大学附属第十人民医院确诊为POLEmut型EC/EAH、并接受FST 13例患者的临床资料,按治疗方案分为孕激素/GnRH-a组(n=8)和ICIs组(n=5)。对比两组患者的治疗、随访及妊娠结局。结果13例患者中,超指征保育7例,其中ICIs组5例。两组患者的完全缓解(CR)率比较,差异无统计学意义(P=1.000),ICIs组中位CR时间(28.2周)短于孕激素/GnRH-a组(35.9周,P=0.450);难治性病例4例,其中孕激素/GnRH-a组3例、ICIs组1例(P=1.000)。ICIs组总随访时间及CR后随访时间均显著短于孕激素/GnRH-a组(中位数21.1个月vs 44.6个月、14.0个月vs 33.8个月,P均<0.05);ICIs组无复发,孕激素/GnRH-a组复发2例(P=0.467)。8例CR患者中7例成功妊娠,其中孕激素/GnRH-a组5例均成功妊娠,4例活产;ICIs组2例成功妊娠,均晚期妊娠。结论对于POLEmut型EC/EAH患者,孕激素/GnRH-a方案与ICIs方案均是有效的FST选择。对于超指征保育患者,ICIs方案似乎显示出更快的起效趋势、更优短期疾病控制效果和良好的生育结局,或可作为更优保育治疗方案。 展开更多
关键词 POLE突变型 子宫内膜癌 子宫内膜非典型增生 保留生育功能治疗 免疫检查点抑制剂
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Quantitative Analysis of Structure-related Spatial Harmonics on Torque Generation in Hybrid Excited Asymmetric Stator Pole Double Salient Machine for Integrated Machine Drive Applications 认领 引用
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作者 Chen Cao Wei Xu +5 位作者 Jian Ge Bin Du Zhongyong Chen Chuanjia Zhang Lili Kang Lei Zhang 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2026年第2期133-143,共11页
With the rapid development of integrated machine drives(IMDs),hybrid excited asymmetric stator pole double salient machines(HEASPDSMs)have gained widespread attention owing to their flexible flux regulation ability,ex... With the rapid development of integrated machine drives(IMDs),hybrid excited asymmetric stator pole double salient machines(HEASPDSMs)have gained widespread attention owing to their flexible flux regulation ability,excellent heat dissipation capacity,and robust structure.As a type of flux modulation machine,HEASPDSMs exhibit numerous magnetic field harmonics due to their double-sided reluctance structure and introduction of asymmetric stator poles and excitation windings.These harmonics cause significant distortions in airgap flux density,back-electromotive-force(back-EMF),and torque.Traditional magnetomotive force(MMF)-specific permeance analytical methods fail to quantify the torque contribution of individual structural-related spatial harmonics,which restricts the torque density improvement of HEASPDSMs.To mitigate the torque distortion and improve torque density,a novel evaluation model for both average torque and torque ripple of HEASPDSMs is proposed in this paper.Different from classical methods,the proposed model directly utilizes statorotor MMF and specific permeance as modulation components for torque calculation,which can quantitatively clarify the individual contribution of each modulation harmonic to torque and establish a direct correlation between harmonic contribution and structural parameters.Furthermore,its accuracy is validated via finite element analysis(FEA)by performing single-parameterscan on four HEASPDSMs with different pole-pair combinations,during which the torque performance and flux regulation ability are analyzed.Finally,experimental validation is performed on a 12s7p HEASPDSM prototype to further verify the proposed model. 展开更多
关键词 Hybrid excited asymmetric stator pole double salient machine(HEASPDSM) integrated machine drive(IMD) structure-related spatial harmonics torque model
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POLE在结直肠癌中的作用及临床意义 认领 引用
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作者 邓依旋 吴凌亚 +1 位作者 王玉红 黄山 《临床与实验病理学杂志》 CAS 北大核心 2026年第5期569-578,共10页
目的分析DNA聚合酶ε(DNA polymerase epsilon,POLE)与微卫星不稳定性(microsatellite instability,MSI)之间的关联与作用,探究POLE在结直肠癌(colorectal cancer,CRC)发生、发展中的作用及机制。方法利用免疫组化法检测POLE在CRC组织... 目的分析DNA聚合酶ε(DNA polymerase epsilon,POLE)与微卫星不稳定性(microsatellite instability,MSI)之间的关联与作用,探究POLE在结直肠癌(colorectal cancer,CRC)发生、发展中的作用及机制。方法利用免疫组化法检测POLE在CRC组织及癌旁组织中的表达差异,并通过TCGA数据库及GEO数据库完成CRC中POLE的生存分析、差异分析及富集分析。采用Western blot检测CRC细胞系中POLE的蛋白表达水平。构建POLE低表达的CRC细胞系,通过划痕和CCK-8实验评估CRC细胞的增殖与迁移能力。结果POLE在CRC组织中的表达显著高于癌旁组织(P<0.05),且在MSI的CRC患者中表达显著高于微卫星稳定(microsatellite stability,MSS)的CRC患者(P<0.05)。Kaplan-Meier生存曲线显示,POLE高表达患者的总生存期显著高于低表达患者(P<0.05)。差异分析与富集分析提示POLE的上调关键基因TACC3富集于多条促进CRC发生、发展的信号通路。POLE与TACC3在MSI细胞系中的表达高于MSS细胞系。当POLE被敲低时,TACC3在CRC细胞中的表达降低,且CRC细胞的增殖与迁移能力降低(P<0.05)。结论POLE在CRC组织中高表达,敲低POLE可抑制CRC细胞的增殖和迁移能力。POLE可能通过调控其关键上调基因TACC3参与细胞衰老过程,进而促进CRC发生、发展,可作为CRC患者预后及治疗的潜在生物学标志物。 展开更多
关键词 结直肠癌 POLE 微卫星不稳定性 TACC3 细胞衰老
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Quantitative Stress Testing Using Scalable Digital Twin Simulation with MobileX Pole for Intelligent Mobile Surveillance 认领 引用
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作者 DongHwan Ku Sun Park JongWon Kim 《Computers, Materials & Continua》 SCIE EI 2026年第8期1290-1311,共22页
In future smart cities,ensuring urban safety requires data-driven decision-making through real-time monitoring tailored to dynamic,complex environments.Such surveillance relies on diverse mobile sensor devices,includi... In future smart cities,ensuring urban safety requires data-driven decision-making through real-time monitoring tailored to dynamic,complex environments.Such surveillance relies on diverse mobile sensor devices,including drones,robots,patrol vehicles,and portable sensors.However,scaling and validating these systems directly in the real world is constrained by high costs,safety risks,and limited reproducibility across operating conditions.A scalable Digital Twin(DT)model can overcome these constraints by reproducing real-world mobile surveillance in a virtual environment,enabling large-scale simulations of sensor deployment,communication scenarios,and high-density visual data processing.Nevertheless,digital twins still face well-known limitations such as the reality gap,construction costs,limited coverage of behavioral and social variables,biased learning in AI models,and the need for continuous updates.Many of these issues are expected to be mitigated in the near future as generative AI increasingly automates the construction of virtual environments and objects.Despite these advancements,the systemic resource constraints of integrating large-scale physical sensor streams with virtual rendering remain underexplored.To address this gap,this paper proposes a scalable DT framework for the quantitative stress testing of intelligent mobile surveillance systems.The proposed framework collects real-world visualization data from multiple cameras mounted on MobileX Poles,and supports quantitative stress testing in both virtual and physical environments.It systematically analyzes how computing resource usage varies with the number of smart poles and the total number of camera streams under rendering conditions,thereby quantifying the resource limits of real-world,multi-camera DT simulations. 展开更多
关键词 Quantitative stress testing scalable digital twin MobileX Pole intelligent mobile surveillance
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Ⅳ期子宫内膜样癌POLE超突变型保留生育功能1例病例报告 认领 引用
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作者 冯艺帆 刘媛媛 王建六 《中国妇产科临床杂志》 CSCD 北大核心 2026年第2期159-160,共2页
一、病例摘要患者女性,30岁,平素月经不规律,7~28 d/35~60 d,因月经淋漓不尽,2020年4月于当地行宫腔镜检查,镜下见宫腔内充满息肉样增生,表面血管分布。术后病理回报子宫内膜癌(endometrial carcinoma,EC),中分化。山东大学齐鲁医院病... 一、病例摘要患者女性,30岁,平素月经不规律,7~28 d/35~60 d,因月经淋漓不尽,2020年4月于当地行宫腔镜检查,镜下见宫腔内充满息肉样增生,表面血管分布。术后病理回报子宫内膜癌(endometrial carcinoma,EC),中分化。山东大学齐鲁医院病理会诊考虑中分化EC,北京协和医院病理会诊考虑高分化EC。既往婚后2年未孕,监测排卵考虑多囊卵巢综合征,体质指数21.5 kg/m2,孕1产0,人工流产1次,无肿瘤、高血压及糖尿病等家族史。盆腔增强磁共振成像(MRI)提示宫腔内占位性病变3.8 cm×2.6 cm×4.7 cm,累及子宫浅肌层,考虑子宫内膜癌ⅠA期。 展开更多
关键词 保留生育功能 病例报告 POLE超突变型
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GADD45A与POLE3介导基因组不稳定性重塑宫颈癌免疫微环境的机制 认领 引用
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作者 李珊 梁彩霞 +1 位作者 李朝明 戴梦源 《武汉大学学报（医学版）》 CAS 2026年第7期891-900,共10页
目的:探讨GADD45A与POLE3在宫颈癌中的表达特征及其对细胞生物学行为和患者预后的影响。方法:采用免疫组织化学染色(IHC)检测69例宫颈癌组织及23例正常宫颈组织中GADD45A与POLE3的蛋白表达水平,在HeLa与SiHa细胞系中分别构建oeGADD45A(... 目的:探讨GADD45A与POLE3在宫颈癌中的表达特征及其对细胞生物学行为和患者预后的影响。方法:采用免疫组织化学染色(IHC)检测69例宫颈癌组织及23例正常宫颈组织中GADD45A与POLE3的蛋白表达水平,在HeLa与SiHa细胞系中分别构建oeGADD45A(过表达)及siPOLE3(敲低)模型,通过CCK‑8法、平板克隆形成实验、流式细胞术评价细胞增殖、凋亡及周期的变化。利用转录组测序分析二者调控的差异表达基因集及富集通路,并基于TCGA数据库评估其与患者总生存期的相关性。结果:IHC显示宫颈癌组织中GADD45A表达显著下调,而POLE3表达显著上调,且在HPV16阳性组中升高尤为明显(P<0.05)。功能实验显示,oeGADD45A或siPOLE3均可显著抑制宫颈癌细胞增殖并诱导细胞凋亡(P<0.05);周期分析表明oeGADD45A可引起S期阻滞;测序分析揭示oeGADD45A与siPOLE3诱导的转录组变化高度相似,差异基因主要富集于核小体组装、DNA损伤应答及干扰素信号通路;TCGA生存分析显示,POLE3高表达与宫颈癌患者的不良预后显著相关(P<0.01),而GADD45A高表达预示患者生存获益。结论:GADD45A在宫颈癌中发挥抑癌作用,而POLE3为促癌因子;二者可能通过共同调控DNA损伤修复与免疫应答通路影响宫颈癌进展,可作为临床预后评估及靶向治疗的潜在标志物。 展开更多
关键词 宫颈癌 GADD45A POLE3 人乳头瘤病毒 免疫微环境 免疫检查点
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POLE突变亚型子宫内膜癌的临床病理及分子特征分析 认领 引用
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作者 黄思家 余淼 +1 位作者 张雪晴 翁海燕 《临床与实验病理学杂志》 CAS 北大核心 2026年第6期726-732,共7页
目的探讨POLE突变亚型子宫内膜癌(POLE-mutant endometrial carcinoma,POLE-mut EC)的临床病理特征及分子遗传学特征,并为临床治疗策略提供理论依据。方法回顾性分析2019年1月至2021年12月在中国科学技术大学附属第一医院接受手术切除... 目的探讨POLE突变亚型子宫内膜癌(POLE-mutant endometrial carcinoma,POLE-mut EC)的临床病理特征及分子遗传学特征,并为临床治疗策略提供理论依据。方法回顾性分析2019年1月至2021年12月在中国科学技术大学附属第一医院接受手术切除且经下一代测序分子分型的101例子宫内膜癌(endometrial carcinoma,EC)患者资料,筛选出其中13例伴有POLE-mut病例纳入研究队列。收集患者临床病理特征及预后信息,复阅石蜡及免疫组化切片,分析基因检测数据,并复习相关文献。结果13例伴有POLE-mut EC中,12例(12/101,11.9%)突变位于已知致病性位点,1例突变位点为S459Y。患者年龄50~73岁(中位57岁,平均57岁)。组织学类型包括子宫内膜样癌(endometrioid endometrial carcinoma,EEC)10例,高级别浆液性癌2例,1例为透明细胞癌。参考2023版国际妇产科联盟(international federation of gynecology and obstetrics,FIGO)内膜癌分期标准,多数病例分期为ⅠAm POLE-mut期。POLE-mut EC多为侵袭性EC(69%),其中高级别(G3)EEC 6例(46%),多伴浅肌层浸润8例(62%),肿瘤浸润性淋巴细胞显著9例(69%),无/局灶脉管癌栓11例(85%),无淋巴结转移12例(92%)。基因共突变者8例,合并TP53突变者6例(免疫组化均呈亚克隆性表达模式),合并高度微卫星不稳定(microsatellite instability-high,MSI-H)者2例,无同时合并TP53突变及MSI-H者。13例患者中8例接受术后化疗和/或放疗,5例未行辅助治疗。1例ⅠAm POLE-mut患者术后1年出现肺转移,其余12例随访10~63个月无复发及转移。结论POLE-mut EC可具有低分化癌的组织学形态,但患者大多预后良好,无须进一步的辅助治疗,准确的POLE-mut检测对指导临床治疗决策具有重要意义。其次,在治疗高级别EC时,临床工作者应整合分子分型与传统风险因素,综合判断是否需要进行降级治疗。 展开更多
关键词 子宫内膜肿瘤 POLE基因 突变位点
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Design and optimization of quadrupole and sextupole magnets for Shenzhen Innovation Light-source Facility storage ring 认领 引用
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作者 Zhu Jiawu Zhang Miao Wang Yong 《强激光与粒子束》 CAS CSCD 北大核心 2025年第7期83-90,共8页
As an advanced 4th generation synchrotron radiation facility,the Shenzhen Innovation Light-source Facility(SILF)storage ring is based on multi-bend achromat(MBA)lattices,enabling one to two orders of magnitude redu... As an advanced 4th generation synchrotron radiation facility,the Shenzhen Innovation Light-source Facility(SILF)storage ring is based on multi-bend achromat(MBA)lattices,enabling one to two orders of magnitude reduction in beam emittance compared to the 3rd generation storage ring.This significantly enhance the radiation brightness and coherence.The multipole magnets of many types for SILF storage ring are under preliminary design,which require high integral field homogeneity.As a result,a dedicated pole tip optimization procedure with high efficiency is developed for quadrupole and sextupole magnets with Opera-2D■python script.The procedure considers also the 3D field effect which makes the optimization more straightforward.In this paper,the design of the quadrupole and sextupole magnets for SILF storage ring is first presented,followed by a detailed description of the implemented pole shape optimization method. 展开更多
关键词 synchrotron radiation facility quadrupole magnet sextupole magnet pole shape optimization
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Fast and Accurate Prediction of Electromagnetic and Temperature Fields for SPMSM Equipped with Unequally Thick Magnetic Poles 认领 引用 被引量：3
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作者 Feng Liu Xiuhe Wang +1 位作者 Lingling Sun Hongye Wei 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2025年第2期199-211,共13页
With the continuous upgrading of traditional manufacturing industries and the rapid rise of emerging technology fields,the performance requirements for the permanent magnet synchronous motors(PMSMs)have become higher ... With the continuous upgrading of traditional manufacturing industries and the rapid rise of emerging technology fields,the performance requirements for the permanent magnet synchronous motors(PMSMs)have become higher and higher.The importance of fast and accurate electromagnetic thermal coupling analysis of such motors becomes more and more prominent.In view of this,the surfacemounted PMSM(SPMSM)equipped with unequally thick magnetic poles is taken as the main object and its electromagnetic thermal coupling analytical model(ETc AM)is investigated.First,the electromagnetic analytical model(EAM)is studied based on the modified subdomain method.It realizes the fast calculation of key electromagnetic characteristics.Subsequently,the 3D thermal analytical model(TAM)is developed by combining the EAM,the lumped parameter thermal network method(LPTNM),and the partial differential equation of heat flux.It realizes the fast calculation of key thermal characteristics in 3D space.Further,the information transfer channel between EAM and TAM is built with reference to the intrinsic connection between electromagnetic field and temperature field.Thereby,the novel ETcAM is proposed to realize the fast and accurate prediction of electromagnetic and temperature fields.Besides,ETcAM has a lot to commend it.One is that it well accounts for the complex structure,saturation,and heat exchange behavior.Second,it saves a lot of computer resources.It offers boundless possibilities for initial design,scheme evaluation,and optimization of motors.Finally,the validity,accuracy,and practicality of this study are verified by simulation and experiment. 展开更多
关键词 Electromagnetic field and temperature field Electromagnetic thermal coupling analytical model(ETcAM) Fast and accurate prediction SPMSM Unequally thick magnetic poles
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POLE基因突变型子宫内膜癌的免疫特征分析 认领 引用
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作者 黄育刚 苏小敏 +1 位作者 王莉 汤显斌 《中国免疫学杂志》 CAS CSCD 北大核心 2025年第4期908-914,共7页
目的:探讨POLE基因突变型子宫内膜癌(EC)的免疫特征。方法:收集2020年12月至2022年10月十堰市太和医院病理科存档的104例EC石蜡包埋组织样本,包括11例POLE突变型和93例POLE野生型。免疫组化检测EC组织中CD4、CD8、PD-L1蛋白表达;结合TCG... 目的:探讨POLE基因突变型子宫内膜癌(EC)的免疫特征。方法:收集2020年12月至2022年10月十堰市太和医院病理科存档的104例EC石蜡包埋组织样本,包括11例POLE突变型和93例POLE野生型。免疫组化检测EC组织中CD4、CD8、PD-L1蛋白表达;结合TCGA数据库分析POLE基因突变型的免疫浸润情况,主要包括CD4、CD8、PD-L1 mRNA的表达及相关预后分析。结果:基于TCGA数据集,与POLE野生型EC相比,POLE突变型的趋化因子家族、免疫细胞表面标志物及溶菌酶等基因的表达差异显著(均P0.05)。结论:在EC患者中,CD8+T细胞浸润丰度、PD-L1表达情况对POLE突变型的预后或治疗具有重要价值。 展开更多
关键词 子宫内膜癌 POLE突变 免疫特征分析 生物信息学分析
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Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis 认领 引用
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作者 Yan-Fei Feng Hui-Kun Zhou +8 位作者 Bo-Bin Hu Hang Wang Heng-Kai Liang Lu Wei Qing-Mei Li Tu-Mei Su Qian-Bing Yin Ming-Hua Su Jian-Ning Jiang 《World Journal of Hepatology》 2025年第7期221-232,共12页
BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging e... BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients. 展开更多
关键词 Extra spindle pole bodies-like 1 p53 antibody Hepatocellular carcinoma Hepatitis B virus Diagnostic biomarker Case-control study
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Evaluating Euler pole parameters for the north American terrestrial reference frame of 2022 认领 引用
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作者 Mohammad Ali Goudarzi 《Geodesy and Geodynamics》 EI CSCD 2025年第6期681-692,共12页
Euler Pole Parameters(EPPs)were estimated for the new plate-fixed North American Terrestrial Reference Frame of 2022(NATRF2022)based on the spherical model of Earth using different sets of continuously operating GPS(c... Euler Pole Parameters(EPPs)were estimated for the new plate-fixed North American Terrestrial Reference Frame of 2022(NATRF2022)based on the spherical model of Earth using different sets of continuously operating GPS(cGPS)station velocities.Two objectives were considered in this research:(1)the possibility of using the cGPS stations located in the areas affected by the Glacial Isostatic Adjustment(GIA),and(2)minimizing the reference frame velocities across the entire continent for conventional uses such as surveying and mapping.A key consideration in this analysis is accounting for the impact of the ongoing GIA on the horizontal velocities.The predicted horizontal velocities from the ICE-6G model were used to remove the GIA effect from the velocity field to mitigate such biases.As a proof of concept,different data sets from a large set of cGPS station velocities were selected,and EPPs were estimated for all these sets of stations with and without removing the GIA effect and estimating or not estimating the Plate Translation Rate(PTR).Considering the WRMS as the criterion for showing goodness of fit,the results show that accounting for the GIA effect reduces the NATRF2022 velocities.Using the same velocity dataset,the PTR was estimated along with the conventional Euler's rotation parameters,and it was shown that estimating the PTR term can further reduce the NATRF2022 velocities. 展开更多
关键词 Reference frame North America tectonic plate Euler pole parameters Plate translation rate NATRF2022
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不同PD-1单抗治疗POLE基因突变型结直肠癌疗效的比较 认领 引用 被引量：1
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作者 陈盼盼 陈翠珊 +2 位作者 潘庆善 杨曦 周捷 《中国处方药》 2025年第18期6-10,共5页
目的明确治疗DNA聚合酶ε催化亚单位(POLE)基因突变型结直肠癌首选的程序性死亡受体-1(PD-1)单抗。方法收集确诊晚期POLE基因突变型结直肠癌患者的临床资料,按使用不同的PD-1单抗分为帕博利珠单抗组(Pem组)、特瑞普利单抗组(Tor组)、替... 目的明确治疗DNA聚合酶ε催化亚单位(POLE)基因突变型结直肠癌首选的程序性死亡受体-1(PD-1)单抗。方法收集确诊晚期POLE基因突变型结直肠癌患者的临床资料,按使用不同的PD-1单抗分为帕博利珠单抗组(Pem组)、特瑞普利单抗组(Tor组)、替雷利珠单抗组(Tis组)、信迪利单抗组(Sin组)四个组别。按Recist 1.1标准评价药物的疗效。以患者首次接受PD-1单抗治疗为生存时间起点计算无事件生存期(EFS),绘制Kaplan-Meier生存曲线,并用Log-Rank进行检验。对比分析用药前后癌胚抗原(CEA)、糖类抗原19-9(CA19-9)和糖类抗原72-4(CA72-4)等肿瘤标志物的检测结果。统计分析用药过程中各组不良反应的发生率。结果客观缓解率(ORR)高低依次为Pem组(66.67%)、Tor组(53.33%)、Tis组(50.00%)、Sin组(43.75%),各组差异无统计学意义(P>0.05)。EFS依次为Pem组11.45个月、Tis组9.68个月、Tor组9.32个月、Sin组8.85个月。经Log-Rank检验,Pem组累计生存比例显著高于Sin组(P0.05)。结论对于POLE基因突变型结直肠癌,可首选帕博利珠单抗进行治疗,特瑞普利单抗次选,最后考虑替雷利珠单抗或信迪利单抗。 展开更多
关键词 POLE基因 结直肠癌 PD-1单抗
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信迪利单抗联合贝伐珠单抗转化治疗POLE~(P286R)突变型结直肠癌1例 认领 引用
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作者 杨俊豪 姚光宇 +3 位作者 马晓婷 刘莲 王晰程 巴一 《中国肿瘤临床》 CAS CSCD 北大核心 2025年第18期971-972,共2页
患者男性,44岁。2023年6月开始出现间断性右腹痛,发作时可扪及右侧中下腹凸起肿块,自服“胃药”后未有好转。2024年7月患者于当地医院行腹部增强CT,显示右侧结肠肝区壁有局限性不规则增厚,密度欠均匀,增强呈不均匀明显强化;胰头区结节... 患者男性,44岁。2023年6月开始出现间断性右腹痛,发作时可扪及右侧中下腹凸起肿块,自服“胃药”后未有好转。2024年7月患者于当地医院行腹部增强CT,显示右侧结肠肝区壁有局限性不规则增厚,密度欠均匀,增强呈不均匀明显强化;胰头区结节样软组织密度影,边缘清晰光滑,与胰头分界欠清,增强呈不均匀强化,提示恶性可能。 展开更多
关键词 POLE 结直肠癌 免疫治疗 抗血管生成治疗 转化治疗
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Simultaneous second and third harmonics generation in periodically poled lithium niobate:Coupling and competition 认领 引用
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作者 Junming Liu Liqiang Liu +1 位作者 Lihong Hong Zhiyuan Li 《Chinese Physics B》 SCIE EI CAS CSCD 2025年第8期591-599,共9页
Conventional approaches for obtaining the second and third harmonics typically employ several nonlinear crystals to generate them,which is restricted in application due to the complexity of the optical path and the bu... Conventional approaches for obtaining the second and third harmonics typically employ several nonlinear crystals to generate them,which is restricted in application due to the complexity of the optical path and the bulkiness of the device.In this work,we present a comprehensive theoretical and numerical investigation of the simultaneous generation and competition between the second harmonic waves(SHW)and the third harmonic waves(THW)in a single nonlinear crystal.Through analyzing both small-signal and large-signal regimes,we reveal the complex coupling mechanisms between SHW and THW generation processes.Using periodically poled lithium niobate as an example,we demonstrate that the relative conversion efficiencies between SHW and THW can be freely adjusted by controlling the input fundamental wave power.This work provides new insights for designing efficient frequency converters capable of generating both SHW and THW outputs with controllable intensity ratios. 展开更多
关键词 second harmonic generation third harmonic generation quasi-phase matching periodically poled lithium niobate
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