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Processing-induced reduction in dianthrones content and toxicity of Polygonum multiflorum:Insights from ultra-high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment 认领 引用
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作者 Wan-Fang Li Ying Wang +4 位作者 Cai-Xia Qiu Jie Li Jie Bao Jian-Bo Yang Hong-Tao Jin 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第4期685-695,共11页
Background:Polygonum multiflorum-induced liver injury(PM-DILI)has significantly hindered its clinical application and development.Methods:This study investigates the variation in content and toxicity of dian-thrones,t... Background:Polygonum multiflorum-induced liver injury(PM-DILI)has significantly hindered its clinical application and development.Methods:This study investigates the variation in content and toxicity of dian-thrones,the toxic components of P.multiflorum,during different processing cycles.We employed the ultra-high-performance liquid chromatography triple quadrupole mass spectrometry method to quantify six dianthrones in raw P.multiflorum and formulations processed with a method called nine cycles of steaming and sunning.Additionally,toxicity assessments were conducted using human normal liver cell line L02 and zebrafish embryos.Results:Results indicate a gradual reduction in dianthrones content with increasing processing cycles.Processed formulations exhibited significantly reduced cytotoxic-ity in L02 cells and hepatotoxicity in zebrafish embryos.Conclusions:Our findings elucidate the relationship between processing cycles and P.multiflorum toxicity,providing theoretical support for its safe use. 展开更多
关键词 dianthrones hepatotoxicity Polygonum multiflorum Thunb. ultra-high performance liquid chromatography triple quadrupole mass spectrometry(UHPLC-QQQ-MS/MS) zebrafish embryos
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Research progress on anti-inflammatory effect and mechanisms of the active components of Polygonum cuspidatum 认领 引用
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作者 Shi-Qing Zhang Xing-Qin Cao +2 位作者 Ming-Jiang Mao Jie Ouyang Ying Guo 《Traditional Medicine Research》 2025年第6期54-64,共11页
Diseases resulting from exaggerated inflammatory responses present a significant peril to human beings,and its pathogenesis and treatment have not been fully elaborated.Traditional Chinese medicine offers the benefit ... Diseases resulting from exaggerated inflammatory responses present a significant peril to human beings,and its pathogenesis and treatment have not been fully elaborated.Traditional Chinese medicine offers the benefit of minimal adverse effects and favorable outcomes in the management of inflammatory diseases.Polygonum cuspidatum,a type of traditional Chinese medicine,refers to the dried rhizomes and roots of the plant species Polygonum cuspidatum from the Polygonaceae family.It has a slightly bitter taste and exhibits a cold nature,exhibiting therapeutic effects such as heat-clearing and detoxification,blood stasis removal and pain relief,phlegm resolution,and cough alleviation.Research has demonstrated that the bioactive constituents found in Polygonum cuspidatum can impede the inflammatory response through the modulation of pertinent pathways.The anti-inflammatory effects of it have been primarily observed in nonalcoholic fatty liver disease,arthritis,ischemic stroke,parkinson’s disease,ulcerative colitis,and diabetes mellitus.This review is conducted by combining papers from the past decade.The anti-inflammatory properties and mechanisms of Polygonum cuspidatum and its natural compounds are summarized.It provides a new theoretical basis for further research on the clinical pharmacological effects of Polygonum cuspidatum. 展开更多
关键词 Polygonum cuspidatum anti-inflammatory mechanisms NF-κB pathway AMPK pathway JAK/STAT pathway
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Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population 认领 引用 被引量：15
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作者 Wan-Na Yang Li-Li Pang +8 位作者 Ji-Yuan Zhou Yuan-Wang Qiu Liang Miao Shou-Yun Wang Xiang-Zhong Liu Kang-An Tan Wan-Wan Shi Gui-Qiang Wang Feng-Qin Hou 《World Journal of Gastroenterology》 SCIE CAS 2020年第12期1329-1339,共11页
BACKGROUND Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China.HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury(PM-DILI).However,li... BACKGROUND Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China.HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury(PM-DILI).However,little is known about the relationship between single-nucleotide polymorphisms(SNPs) and PM-DILI.AIM To identify SNPs that indicate susceptibility to PM-DILI METHODS We conducted a systematic study enrolling 382 participants from four independent hospitals,including 73 PM-DILI patients,118 patients with other drug-induced liver injury(other-DILI) and 191 healthy controls.Whole-exome sequencing was performed for 8 PM-DILI patients and 8 healthy controls who were randomly selected from the above subjects.Nineteen SNPs that showed high frequencies in the 8 PM-DILI patients were selected as candidate SNPs and then screened in 65 PM-DILI patients,118 other-DILI patients and 183 healthy controls using the MassARRAY system.HLA-B high-resolution genotyping was performed for the 73 PM-DILI and 118 other-DILI patients.The Han-MHC database was selected as a population control for HLA-B analysis.P <6.25 x 103 after Bolferroni correction was considered significant.RESULTS The frequencies of rslll686806 in the HLA-A gene,rs1055348 in the HLA-B gene,and rs202047044 in the HLA-DRB1 gene were significantly higher in the PM-DILI group than in the control group [27.2% vs 11.6%,P=1.72×105,odds ratio(OR)=3.96,95% confidence interval(Cl):2.21-7.14;42.5% vs 8.6%,P=1.72×10-19 OR=13.62,95% CI:7.16-25.9;22.9% vs 8.1%,P=4.64×106,OR=4.1,95% CI:2.25-7.47].Only rs1055348 showed a significantly higher frequency in the PM-DILI group than in the other-DILI group(42.5% vs 13.6%,P=1.84×10-10,OR=10.06,95% Cl:5.06-20.0),which suggested that it is a specific risk factor for PM-DILI.rs1055348 may become a tag for HLA-B*35:01 with 100% sensitivity and 97.7% specificity in the PM-DILI group and 100% sensitivity and 98.1% specificity in the other-DILI group.Furthermore,HLA-B*35:01 was confirmed to be associated with PM-DILI with a frequency of 41.1% in the PM-DILI group compared with 11.9%(P=4.30×10-11,OR=11.11,95% CI:5.57-22.19) in the other-DILI group and 2.7%(P=6.22×10-166,OR=62.62,95% Cl:35.91-109.20) in the Han-MHC database.CONCLUSION rslll686806,rs1055348,and rs202047044 are associated with PM-DILI,of which,rs1055348 is specific to PM-DILI.As a tag for HLA-B*35:01,rs1055348 may become an alternative predictive biomarker of PM-DILI. 展开更多
关键词 Drug-induced liver injury Polygonum multiflorum Single-nucleotide polymorphism rs111686806 rs1055348 rs202047044 HLA-B*35
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Analysis of the Phytochemistry and Bioactivity of the Genus Polygonum of Polygonaceae 认领 引用 被引量：15
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作者 Bing-Bing SHEN Yu-Pei YANG +5 位作者 Sumera Yasamin Na LIANG Wei SU Sheng-Huang CHEN Xiao-Juan WANG Wei WANG 《Digital Chinese Medicine》 CAS 2018年第1期19-36,共18页
The main chemical constituents of the genus Polygonum(Polygonaceae)are flavonoids,quinones,phenylpropanoids,and terpenoids,which show anticancer,antitumor,anti-oxidative,anti-inflammatory,analgesic,antibacterial,insec... The main chemical constituents of the genus Polygonum(Polygonaceae)are flavonoids,quinones,phenylpropanoids,and terpenoids,which show anticancer,antitumor,anti-oxidative,anti-inflammatory,analgesic,antibacterial,insecticidal,and other pharmacological effects.This paper summarizes research on the chemical constituents and pharmacological effects of compounds from the genus Polygonum in last15years. 展开更多
关键词 Polygonum Chemical constituents Bioactivity Flavonoid Anticancer
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Three New Anthraquinones from Polygonum cillinerve 认领 引用 被引量：10
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作者 Huan Yang QI Chao Feng ZHANG +2 位作者 Mian ZHANG Jian Qun LIU Zheng Tao WANG 《Chinese Chemical Letters》 SCIE CAS 2005年第8期1050-1052,共3页
Three new anthraquinones, emodin-8-β-D-（2＂-O-coumarate）glucoside 1, emodin-8-β-D-（6＇-O-acetyl）glucoside 2 and physicon-8-β-D-（6＇-O-acetyl）glucoside 3, were isolated from the roots of Polygonum cillinerve a... Three new anthraquinones, emodin-8-β-D-（2＂-O-coumarate）glucoside 1, emodin-8-β-D-（6＇-O-acetyl）glucoside 2 and physicon-8-β-D-（6＇-O-acetyl）glucoside 3, were isolated from the roots of Polygonum cillinerve and their structures were established by spectroscopic methods. The biological activity indicated that compound 1 had the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl （DPPH） radicals （the IC50 = 8.5 μmol/L）, and compound 1-3 showed no activities against HL-60 and BCJC-823 cells by MTT method in vitro. 展开更多
关键词 Polygonum cillinerve anthraquinone antioxidant activity cytotoxic activity.
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Simultaneous determination of eight flavonoids in Polygonum aviculare L. by RP-HPLC-UV 认领 引用 被引量：11
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作者 付庆荣 刘淑娟 +1 位作者 王弘 陈世忠 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第3期170-176,共7页
A reliable high performance liquid chromatography method was developed for the quality evaluation of Polygonum aviculare L. Eight marker flavonoids were identified and simultaneously quantified, which included myricit... A reliable high performance liquid chromatography method was developed for the quality evaluation of Polygonum aviculare L. Eight marker flavonoids were identified and simultaneously quantified, which included myricitrin, hyperoside, galuteolin, avicularin, quercitrin, quercetin, luteolin, and kaempferol. The analysis was performed on an Inertsil ODS-4 column（4.6 mm×150 mm, 5 μm） with gradient elution. The mobile phases were 0.5% aqueous phosphoric acid and acetonitrile. The detection wavelength was 360 nm. The eight marker flavonoids were separated well with good linearity（r20.9991）, precision, stability and repeatability. The recovery rate was 95.58%–102.65%. Cluster analysis was employed to analyze 28 batches of samples. The result indicated that this method provides an efficient way to perform quality control as well as a scientific rationale for the Geo-authentication of Polygonum aviculare L. 展开更多
关键词 Polygonum aviculare L. Flavonoids Quantitative analyses Cluster analysis
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A novel dimeric procyanidin glucoside from Polygonum aviculare 认领 引用 被引量：3
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作者 Hai Jian Cong Shu Wei Zhang +2 位作者 Chong Zhang Yu Jie Huang Li Jiang Xuan 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第7期820-822,共3页
A novel dimeric procyanidin glucoside,catechin 3-O-acetate-（4 α→8）-catechin 3-O-acetate-3＇-O- β-D-glucopyranoside（1）, along with five flavonoids and one lignan were isolated from the aerial parts of Polygonum ... A novel dimeric procyanidin glucoside,catechin 3-O-acetate-（4 α→8）-catechin 3-O-acetate-3＇-O- β-D-glucopyranoside（1）, along with five flavonoids and one lignan were isolated from the aerial parts of Polygonum aviculare.Their structures were elucidated by spectroscopic analyses including 1D,2D NMR,MS and CD methods. 展开更多
关键词 Polygonum aviculare Polygonaceae Procyanidin glucoside Catechin
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Two new coumarin glucosides biosynthesized by transgenic hairy roots of Polygonum multiflorum 认领 引用 被引量：5
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作者 Rong Min Yu Liang Bin Zhou +2 位作者 Chun Yan Yan Guo Yan Duan Yu Zhao 《Chinese Chemical Letters》 SCIE CAS 2008年第1期76-78,共3页
The glycosylation of hydroxylcoumarin was investigated by using suspension cultures of hairy roots of Polygonum multiflorum. Two new coumarin glucosides （3 and 4） were biosysthesized by regioselectively glycosylatio... The glycosylation of hydroxylcoumarin was investigated by using suspension cultures of hairy roots of Polygonum multiflorum. Two new coumarin glucosides （3 and 4） were biosysthesized by regioselectively glycosylation of corresponding substrates （1 and 2） in the system. The structures of two products were identified as 7-hydroxy-4-methylcoumarin 5-O-β-D-glucopyranoside and 7- hydroxy-3,4-dimethylcoumarin 5-O-β-D-glucopyranoside on the ground of chemical and spectroscopic methods, respectively. 2007 Rong Min Yu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Polygonum multiflorum Hairy roots Glycosylation 7-Hydroxy-4-methylcoumarin 5-O-13-o-glucopyranoside 7-Hydroxy-3,4-dimethylcoumarin 5-O-β-D-glucopyranoside
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Comparative analysis of chemical constituents, antimicrobial and antioxidant activities of ethylacetate extracts of Polygonum cuspidatum and its endophytic actinomycete, Streptomyces sp. A0916 认领 引用 被引量：3
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作者 WANG Lei QIU Peng +3 位作者 LONG Xiu-Feng ZHANG Shuai ZENG Zhi-Gang TIAN Yong-Qiang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2016年第2期117-123,共7页
The present study investigated the chemical composition of ethylacetate extracts from an endophytic actinomycete Streptomyces sp. A0916 and its host Polygonum cuspidatum. A comparative analysis of the antimicrobial an... The present study investigated the chemical composition of ethylacetate extracts from an endophytic actinomycete Streptomyces sp. A0916 and its host Polygonum cuspidatum. A comparative analysis of the antimicrobial and antioxidant properties of the extracts was also conducted. 32 compounds of P. cuspidatum and 23 compounds of Streptomyces sp. A0916 were isolated and identified by GC/MS. Antimicrobial activities of the extracts were evaluated using eight microbial strains(3 Gram-positive bacteria, 3 Gram-negative bacteria, and 2 fungi). The Streptomyces sp. A0916 extracts showed a wide range of antimicrobial activities and presented greater antimicrobial effectiveness than the P. cuspidatum extracts. The minimum inhibitory concentration(MIC) of Streptomyces sp. A0916 extracts against the ampicillin-resistant strain Enterococcus faecium SIIA843 was 32 μg·m L-1. Furthermore, the extracts had greater antimicrobial effect against Gram-positive bacteria than Gram-negative bacteria. Finally, the antioxidant activity of the Streptomyces sp. A0916 extracts was equal to that of the P. cuspidatum extracts. In conclusion, our results suggest that the endophytic actinomycetes of the medicinal plants are an important source of bioactive substances. 展开更多
关键词 Polygonum cuspidatum Endophytic actinomycete Ethylacetate extracts GC/MS Antimicrobial activity Antioxidant activity
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In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease 认领 引用 被引量：4
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作者 Li-Ping Yu Yan-Juan Li +5 位作者 Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang 《World Journal of Gastroenterology》 SCIE CAS 2023年第1期171-189,共19页
BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic i... BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear.AIM To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in rats.METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms.The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,respectively.RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD.PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis.Eight chemicals were found in the liver mitochondria of PM-administrated rats.The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated.CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy production.The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD.Thus,PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction.Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases. 展开更多
关键词 Fatty liver Mitochondria Pharmacodynamic ingredients Polygonum multiflorum
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Simultaneous quantitative determination of eight active components in Polygonum multiflorum Thunb by RP-HPLC 认领 引用 被引量：16
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作者 续艳丽 董琦 胡凤祖 《Journal of Chinese Pharmaceutical Sciences》 CAS 2009年第4期358-361,共4页
A sensitive and specific reversed-phase high performance liquid chromatography （RP-HPLC） method was established for the simultaneous quantitative determination of eight active components, two stilbenes （resveratrol... A sensitive and specific reversed-phase high performance liquid chromatography （RP-HPLC） method was established for the simultaneous quantitative determination of eight active components, two stilbenes （resveratrol, polydatin） and six flavonoids （rutin, quercilrin, quercetin, luteotin, isoorientin, kaempferol）, in Polygonum multiflorum Thunb. The chromatographic separation was performed on a Kromasil C18 column （250 mm^4.6 mm, 5 ~tm）, and gradient elution was carried out with water-methanol as the mobile phase at a flow rate of 1 mL/min. Stilbenes and flavonoids were respectively detected at 320 nm and 350 nm with DAD. The correlation coefficients of all the calibration curves were found to be higher than 0.9995. The average recoveries were ranged from 96.8% to 102.5% with RSD less than 4.8% for these components. RP-HPLC was validated to be a robust method for the quantitative determination of active components in Polygonum multiflorum Thunb, and it could be used in the quality control of this traditional medicine. 展开更多
关键词 RP-HPLC Stilbenes Flavonoids Polygonum multiflorum Thunb
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Screening of biological activities of Polygonum maritimum L.from A lgerian coast 认领 引用 被引量：3
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作者 Imad Abdelhamid El-Haci Fawzia Atik Bekkara +2 位作者 Wissame Mazari Fay al Hassani Mohamed AmineDidi 《Asian Pacific Journal of Tropical Biomedicine》 CAS 2013年第8期611-616,共6页
Objective:To investigate the antioxidant and the antibacterial activities of crude extract from aerial part of Polygonum maritimumL.(Polygonaceae)(P.maritimum)and to find new actives biomolecules.Methods:The whole pla... Objective:To investigate the antioxidant and the antibacterial activities of crude extract from aerial part of Polygonum maritimumL.(Polygonaceae)(P.maritimum)and to find new actives biomolecules.Methods:The whole plant was collected from the Rechgoune coast(West of Algeria),and methanolic crude extract of aerial parts ofP.maritimum(PMCE)was prepared.The extract was tested against different bacterial strain and tested for his ability to neutralize free radical(DPPH)and to scavenge the H2O2.Results:PMCE had a very high content of total phenol,which was(352.49依18.03)mg/g dry weight,expressed as gallic acid equivalent.PMCE exhibited excellent antioxidant activity,as measured using DPPH and H2O2 scavenging assays.It also showed a high antibacterial activity against gram-positive bacterial strains:Bacillus cereus,Bacillus subtilisandStaphylococcus aureus with an highest MIC of 120μg/mL.Conclusions:The antioxidant and antibacterial activity of the PMCE is probably due to phenolic compounds present in the extract.The contemporary presence of antioxidant and antibacterialactivities in the PMCE suggests that this plant may be a source of bioactive substances with multifaceted activity. 展开更多
关键词 Polygonum maritimumL. Phenolic compounds Antioxidant activity Antibacterial activity
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Qualitative and Quantitative Analysis of Rhizoma of Polygonum cuspidatum 认领 引用 被引量：5
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作者 张勉 王磊 +2 位作者 黄澜 张紫佳 王峥涛 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第2期106-111,共6页
Aim To establish reliable methods for evaluating the quality of rhizoma of Polygonum cuspidatum( Huzhang in Chinese). Methods TLC and HPLC were employed for the chemical identification and content determination,respec... Aim To establish reliable methods for evaluating the quality of rhizoma of Polygonum cuspidatum( Huzhang in Chinese). Methods TLC and HPLC were employed for the chemical identification and content determination,respectively. Results A qualitative TLC method and a quantitative HPLC method with piceid as the reference substance were established, respectively. With piceid as the reference substance and ethyl acetate-methanol-formic acid-water ( 19:3:0.5:1) as the mobile phase, a TLC method for the identification of Huzhang from the commonly used crude drugs of the same family was also set up. Conclusion The established TLC method can reasonably appraise the quality of the drug and easily distinguish Huzhang from the other commonly used crude drugs of the same family. The HPLC method for determining piceid is simple, reproducible, accurate, and feasible. 展开更多
关键词 TLC HPLC piceid emodin rhizoma of Polygonum cuspidatum
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Response of enzymatic and non-enzymatic antioxidant defense systems of Polygonum hydropiper to Mn stress 认领 引用 被引量：3
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作者 杨贤均 邓冬梅 +1 位作者 刘可慧 于方明 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第4期793-797,共5页
The response of enzyme and non-enzymatic antioxidants of Mn hyperaccumuator, Polygonum hydropiper （P. hydropiper）, to Mn stress was studied using hydroponics culture experiments to explore the mechanism of Mn tolera... The response of enzyme and non-enzymatic antioxidants of Mn hyperaccumuator, Polygonum hydropiper （P. hydropiper）, to Mn stress was studied using hydroponics culture experiments to explore the mechanism of Mn tolerance in this species. Results showed that both chlorophyll and carotenoid contents significantly （p〈0.05） decreased with increasing Mn treatment levels （0, 0.5, 1, 2, 4, and 8 mg/L） in hydroponics. The concentrations of malondialdehyde （MDA） and hydrogen peroxide （H202） in the root and shoot of P hydropiper were accumulated under Mn stress. Meanwhile, the anti-oxidative functions of several important enzymes, including superoxide dismutase （SOD）, catalase （CAT）, ascorbate peroxidase （APX） and peroxidase （POD） in plants were stimulated by Mn spike in leaves and roots, especially at low Mn stress; while sulfhydryl group （--SH） and glutathion （GSH） were likely involved in Mn detoxification ofP. hydropiper under high Mn stress. 展开更多
关键词 Polygonum hydropiper hyperaccumulation enzymatic antioxidative defense non-enzymatic antioxidative defense
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Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum:A case report 认领 引用 被引量：3
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作者 You-Lin Shao Chun-Ming Ma +2 位作者 Jian-Ming Wu Feng-Cai Guo Suo-Cai Zhang 《World Journal of Clinical Cases》 SCIE 2022年第27期9921-9928,共8页
BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes neutropenia.Herein,we report the case of a 65-year-old woman with concurrent severe hepatotoxicit... BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes neutropenia.Herein,we report the case of a 65-year-old woman with concurrent severe hepatotoxicity and agranulocytosis induced by PM.CASE SUMMARY A 65-year-old woman reported with severe hepatotoxicity and agranulocytosis 17 d after ingestion of PM.The results of the Roussel Uclaf Causality Assessment Method demonstrated a highly probable relationship between hepatotoxicity and PM,with a total score of 10.The Naranjo algorithm results indicated that agranulocytosis had a probable relationship with PM,with an overall score of 6.Granulocyte colony-stimulating factor(for once),a steroid,compound glycyrrhizin,and polyene phosphatidylcholine therapy were initiated.After 15 d of treatment,there was a gradual improvement in liver biochemistry,leukocytes,and neutrophils levels.CONCLUSION Concurrent hepatotoxicity and agranulocytosis are rare and critical adverse drug reactions of PM,which should be highly valued. 展开更多
关键词 Polygonum multiflorum Hepatotoxicity Agranulocytosis Case report
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Discovery of pulmonary fibrosis inhibitor targeting TGF-b RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy 认领 引用 被引量：2
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作者 Huarong Xu Jiameng Qu +4 位作者 Jian Wang Kefei Han Qing Li Wenchuan Bi Ran Liu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第6期860-868,共9页
Pulmonary fibrosis(PF)is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2-3 years.The inhibition of transforming growth factor-β receptor type-I(TGF-β... Pulmonary fibrosis(PF)is an irreversible lung disease that is characterized by excessive scar tissue with a poor median survival rate of 2-3 years.The inhibition of transforming growth factor-β receptor type-I(TGF-β RI)by an appropriate drug may provide a promising strategy for the treatment of this disease.Polygonum cuspidatum(PC)is a well-known traditional Chinese herbal medicine which has an anti-PF effect.Accordingly,a combination of high resolution mass spectrometry with an in silico strategy was developed as a new method to search for potential chemical ingredients of PC that target the TGF-β RI.Based on this strategy,a total of 24 ingredients were identified.Then,absorption,distribution,metabolism,and excretion(ADME)-related properties were subsequently predicted to exclude compounds with potentially undesirable pharmacokinetics behaviour.Molecular docking studies on TGF-β RI were adopted to discover new PF inhibitors.Eventually,a compound that exists in PC known as resveratrol was proven to have excellent biological activity on TGF-β RI,with an IC50 of 2.211 μM in vitro.Furthermore,the complex formed through molecular docking was tested via molecular dynamics simulations,which revealed that resveratrol had strong interactions with residues of TGF-β RI.This study revealed that resveratrol has significant potential as a treatment for PF due to its ability to target TGF-β RI.In addition,this research demonstrated the exploration of natural products with excellent biological activities toward specific targets via high resolution mass spectrometry in combination with in silico technology is a promising strategy for the discovery of novel drugs. 展开更多
关键词 Polygonum cuspidatum Pulmonary fibrosis TGF-βreceptor type-I Resveratrol High resolution mass spectrometry Molecular docking
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Clinical analysis of liver injury caused by Chinese patent medicines containing Polygonum multiflorum 认领 引用 被引量：2
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作者 Jie Shen Kai Yang +2 位作者 Caihua Sun Cheng Jiang Minxia Zheng 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2022年第4期289-297,共9页
In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and it... In the present study,we discussed the drug-induced liver injury caused by Chinese patent medicines containing Polygonum multiflorum to provide a reference for clinical rational drug use of Polygonum multiflorum and its preparations.One case of long-term taking Jingwu capsule and Huolisu oral liquid,which led to the drug-induced liver injury,was reported.The other case took Runzaozhiyang capsule for a long time,which also led to drug-induced liver injury.Jingwu capsule,Huolisu oral liquid,and Runzaozhiyang capsule all contained Polygonum multiflorum,which could result in liver injury when used long-term.Moreover,we explored the clinical features and toxicity of liver damage induced by Polygonum multiflorum.Liver damage in serum transaminase was significantly increased,and the increasing rate of ALT was more than that of AST.Jaundice appeared obviously.The liver damage mechanisms included drug metabolism,immune response,physical fitness,and many other reasons.Corresponding suggestions on rational use of Polygonum multiflorum and its preparations were presented.The dosage and period should be regulated.The index of liver function should be monitored during the medication periods.Collectively,patients with a history of liver disease or a history of allergies should pay more attention when using the above-mentioned drugs. 展开更多
关键词 Drug-induced liver injury Polygonum multiflorum Jingwu capsule Huolisu oral liquid Runzaozhiyang capsule
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Anti-hemolytic, antibacterial and anti-cancer activities of methanolic extracts from leaves and stems of Polygonum odoratum 认领 引用 被引量：2
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作者 Nittaya Chansiw Narisara Paradee +1 位作者 Kamonnaree Chotinantakul Somdet Srichairattanakool 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2018年第12期580-585,共6页
Objective: To investigate anti-hemolytic, antibacterial and anti-cancer activities of leaf and stem extracts from Polygonum odoratum. Methods: Leaves and stems of Polygonum odoratum were extracted using methanol and t... Objective: To investigate anti-hemolytic, antibacterial and anti-cancer activities of leaf and stem extracts from Polygonum odoratum. Methods: Leaves and stems of Polygonum odoratum were extracted using methanol and their anti-hemolytic activity was assessed using 2, 2′-Azobis(2-methylpropionamidine) dihydrochloride which is known to generate free radical damage on cell membranes of red blood cells. This damage, represented by hemolysis, was measured using spectrophotometry. Antibacterial activity was tested by using a broth microdilution method to find minimal inhibitory concentrations against eight bacterial strains. Anti-cancer activity of the extracts was evaluated against a human promyelocytic leukemic cell line(HL-60) by using MTT assay for cell viability and flow cytometry for apoptosis induction and cell cycle analysis. Results: Both leaf and stem extracts have anti-hemolytic activity. The results showed a significantly increased percentage of inhibition in a concentration-dependent manner. Interestingly, the leaf extract showed anti-hemolytic activity to a greater extent than the stem extract. Antibacterial activity of the extracts, as indicated by their minimal inhibitory concentration, using 12.5, 50, 25, 25 μg/mL, was measured against Staphylococcus epidermidis, Enterococcus faecium, Enterococcus faecalis and Staphylococcus aureus. The leaf extracts also exhibited anti-cancer activity, demonstrated by significantly decreased cell viability of human promyelocytic cells(HL-60), with an IC50 of(350.00±1.85) μg/mL for 48 h and(38.00±0.92) μg/mL for 72 h. Additionally, HL-60 became apoptotic and accumulated in G_1-phase after 48 hours of treatment. Conclusions: The extracts of Polygonum odoratum exhibit potential antihemolytic activity. They also have antibacterial activity by inhibiting growth of Gram-positive bacteria. The leaf extract shows anti-cancer activity against HL-60 to a greater extent than the stem extract, causing decreased viability, increased G_1-phase accumulation and apoptosis induction. 展开更多
关键词 Polygonum odoratum Anti-hemolysis Antibacterial agents Anti-cancer agents
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Polygonum minus ethanolic extracts attenuate cisplatin-induced oxidative stress in the cerebral cortex of rats via its antioxidant properties 认领 引用 被引量：1
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作者 NR.Adib Ridzuan SL.Teoh +3 位作者 N.Abdul Rashid F.Othman SN.Baharum F.Hussan 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2019年第5期196-203,共8页
Objective: To explore the protective effect of Polygonum minus ethanolic extract on cisplatininduced neurotoxicity.Methods: In vitro test, total phenolic content assay and DPPH assay were performed to determine the an... Objective: To explore the protective effect of Polygonum minus ethanolic extract on cisplatininduced neurotoxicity.Methods: In vitro test, total phenolic content assay and DPPH assay were performed to determine the antioxidant activity of Polygonum minus. For in vivo test, 30 male SpragueDawley rats were randomly divided into 5 groups: the control group, cisplatin 10 mg/kg, Polygonum minus 100 mg/kg, Polygonum minus 200 mg/kg and Polygonum minus 400 mg/kg. The control group and the cisplatin group were given distilled water whereas Polygonum minus groups received the respective dose of Polygonum minus extract orally for 14 d. On day 15, a single intraperitoneal administration of normal saline was given to the control group; while 10 mg/kg of cisplatin was given to the cisplatin group and Polygonum minus groups. Body weight, signs of illness, daily activity and mortality were observed at least once daily throughout the experimental period. On day 18, the anterior part of the brain was collected and processed for histological and ultrastructural analyses(right hemisphere). The remaining part(left hemisphere) of the brain was assayed to determine malondialdehyde and catalase levels for oxidative stress analyses.Results: Polygonum minus ethanolic extract possessed high phenolic content(977.6 mg GAE/g) and 95.9% DPPH radical scavenging activities. No mortality was observed in all groups. Rats in the cisplatin group were weak and less active compared to Polygonum minus treated rats. In the cisplatin group, disorganised cellular layers of the cerebral cortex were observed whereas rats treated with low and mid doses of Polygonum minus extract had normal cerebral cortex as in the control group. Mild ultrastructural changes were observed in rats treated with low and mid doses of Polygonum minus extract. Meanwhile, low and mid doses of Polygonum minus extract significantly reduced malondialdehyde level whereas low and mid doses of Polygonum minus extracts groups significantly increased catalase activity compared to the cisplatin group. Conclusions: Polygonum minus ethanolic extract at 100 and 200 mg/kg attenuates cisplatininduced oxidative stress in the cerebral cortex via its antioxidant activity. 展开更多
关键词 Polygonum minus Cisplatin Neurotoxicity Oxidative stress
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Variation and Cluster Analysis on Leaf Characters from Different Provenance Sources of Polygonum multiflorum Thunb 认领 引用 被引量：2
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作者 韦艳梅 王凌晖 +2 位作者 曹福亮 韦山青 梁耀丹 《Agricultural Science & Technology》 CAS 2010年第6期94-98,共5页
[Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance so... [Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance sources to provide basis for the classification,identification,breeding and improved variety selection of P.multiflorum.[Method] Leaf shape characters of 31 copies of germplasm resources in the major distribution region of the whole country were determined,and the genetic variation of P.multiflorum leaves from different producing areas was analyzed.[Result] The leaf characters of single plant of the same experimental provenance source of P.multiflorum were relatively stable,the variation was mainly found on the single leaf area,1/2 leaf width,leaf width and other indicators;the variation of each leaf character among different provenance sources was obvious,and the variation was mainly found on the single leaf weight,leaf area,1/2 leaf width,leaf length and other indicators.The correlation analysis of each leaf character in P.multiflorum suggested that the single leaf area and single leaf weight showed extremely significant positive correlation with leaf length,1/2 leaf width,leaf width,leaf thickness and leaf stem length,while the single leaf area and single leaf weight showed significant negative correlation with WWR（leaf width/1/2 leaf width）and LWR（leaf length/1/2 leaf length）,in addition,several macroscopic leaf characters such as leaf length,1/2 leaf width,leaf width,leaf stem length showed extremely positive correlation.The main component analysis result suggested that the contribution rate of accumulation variance of the front three main components was up to 97.4%,which could better reflect the comprehensive performance of leaf characters of different provenance sources of P.multiflorum.The cluster analysis showed that the experimental 31 copies of P.multiflorum provenance sources should be divided into three classes,the first class was distributed in the Middle,Western of Guizhou,northwestern of Guangxi and western areas with higher altitude;the second class was distributed in Hunan,Hubei,Sichuan,Guangdong and the most area of Guangxi;the third class was distributed in Anhui,Jiangsu and Henan and Shandong.[Conclusion] Cluster analysis of leaf characters indicated that the kinds of provenance sources which the geographical position was closer could be got together.The study had provided a certain basis for the classification of P.multiflorum. 展开更多
关键词 Polygonum multiflorum Thunb Leaf characters Variation Cluster analysis
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