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Turning the tide in the mitigation of clinically relevant post-operative pancreatic fistula in pancreatoduodenectomy-broad-spectrum antibiotic surgical prophylaxis is the new standard of care 认领 引用
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作者 Bartholomew McKay Elijah Dixon 《Hepatobiliary Surgery and Nutrition》 SCIE 2026年第1期122-125,共4页
Post-operative infectious complications are unfortunately common following pancreatoduodenectomy and their presence significantly affects patient outcomes(1).Post-operative pancreatic fistula(POPF)remains the Achilles... Post-operative infectious complications are unfortunately common following pancreatoduodenectomy and their presence significantly affects patient outcomes(1).Post-operative pancreatic fistula(POPF)remains the Achilles heel of pancreatic resection and the subsequent development of septic complications in relation to POPF can be life-threatening(2).Despite the potential sequela of this complication,effective strategies to mitigate the development of clinically significant grade B/C POPF are lacking(2,3). 展开更多
关键词 Pancreatoduodenectomy antibiotics post-operative pancreatic fistula(POPF)
Gut-brain axis and post-operative cognitive dysfunction:A multifactorial perspective on microbiota,inflammation,and cognitive health 认领 引用
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作者 Rhythm Joshi Nishkarsh Gupta +3 位作者 Anju Gupta Puneet Khanna Nishant Verma Simran Kaur 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2026年第1期92-102,共11页
Post-operative cognitive dysfunction(POCD)is a common but often overlooked issue,especially in older adults after surgery.This review looks into how the gut and brain are connected—a relationship known as the gut-bra... Post-operative cognitive dysfunction(POCD)is a common but often overlooked issue,especially in older adults after surgery.This review looks into how the gut and brain are connected—a relationship known as the gut-brain axis—and how tiny microbes living in our gut might influence our brain health during recovery.The gut microbiota helps produce important substances like short-chain fatty acids and neurotransmitters that play a key role in memory,mood,and brain function.Among these microbes,Akkermansia muciniphila stands out for supporting the gut lining,reducing inflammation,and balancing chemicals that affect cognition.Surgery,anesthesia,and antibiotics can disturb this balance,leading to“gut dysbiosis”,which may trigger brain inflammation and worsen POCD.By reviewing 11 carefully selected studies,this paper explores how restoring gut health—using probiotics like Akkermansia muciniphila or combinations like VSL#3—could be a promising way to protect the brain after surgery.Overall,these findings highlight a powerful connection between gut health and brain recovery,suggesting that personalized probiotic treatments might one day help improve mental outcomes in surgical patients.More clinical studies are needed,but the potential here is both exciting and hopeful. 展开更多
关键词 Gut-brain axis Post-operative cognitive dysfunction Gut microbiota Akkermansia muciniphila Neuroinflammation Short-chain fatty acids Gut dysbiosis Cognitive outcomes after surgery Probiotic intervention Microbiota-based targeted therapy
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Comprehensive strategy for preventing unplanned extubation in patients with post-operative delirium after gastrointestinal surgery 认领 引用
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作者 Yan-Hua Yu Jing-Jing Yang 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第6期207-215,共9页
BACKGROUND Unplanned extubation(UE)is a serious complication in patients with postoperative delirium(POD)after gastrointestinal surgery that significantly increases the risk of reintubation,ventilator-associated pneum... BACKGROUND Unplanned extubation(UE)is a serious complication in patients with postoperative delirium(POD)after gastrointestinal surgery that significantly increases the risk of reintubation,ventilator-associated pneumonia,and mortality.Effective prevention strategies that integrate optimization of sedation-analgesia with structured nursing care are underexplored.AIM To determine an individualized sedation-analgesia strategy based on the risk of UE in patients with POD after gastrointestinal surgery.METHODS Data from 118 patients with POD who required invasive mechanical ventilation for≥24 hours in the intensive care unit,were retrospectively analyzed.Patients were assigned to an intervention group(n=60)or a control group(n=58).Patients in the control group received conventional sedation and single-tape tube fixation,with nursing measures based on clinical experience.Patients in the intervention group had a structured nursing pathway applied that included standardized airway fixation,scheduled delirium assessment,pain monitoring,and early recognition of extubation intention behaviors.RESULTS The intervention group had a lower incidence of UE and a composite endpoint of post-reintubation complications than the control group(P<0.05).Durations of mechanical ventilation,intensive care unit stay,and delirium were significantly shorter in the intervention group(P<0.05).Multivariate Cox regression analysis showed that increased daily fluctuation in the Richmond Agitation-Sedation Scale score,a higher frequency of extubation intention behaviors,insufficient reduction in interleukin-6,delayed intervention response time,high restraint usage,and low nursing assessment completion rates were independent risk factors for UE(P<0.05).CONCLUSION A combined strategy to prevent UE in patients with POD is proposed,and it effectively reduced the incidence of UE and duration of hospitalization,improved nursing quality,and mitigated neuroinflammation. 展开更多
关键词 Post-operative delirium Unplanned extubation Gastrointestinal surgery Sedation-analgesia Endotracheal tube fixation Neuroinflammation Nursing intervention
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Analysis of risk factors for post-operative infection following drugeluting trans arterial chemo embolization in hepatocellular carcinoma:A retrospective study 认领 引用 被引量：1
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作者 Gang Wang Rui Qi 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第6期244-253,共10页
BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment... BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment efficacy and increasing morbidity.AIM To investigate the risk factors associated with post-operative infection in HCC patients undergoing D-TACE,and to provide evidence for clinical prevention and targeted intervention strategies.METHODS Clinical data of 77 primary HCC patients who underwent D-TACE in our hospital from January 2022 to December 2023 were retrospectively analyzed.Patient demographics,laboratory test results,tumor characteristics,and surgery-related parameters were collected.Univariate and multivariate logistic regression analyses were performed to identify risk factors for post-operative infection.RESULTS Post-operative infection occurred in 20 cases(25.97%)among the 77 patients.Univariate analysis showed that age≥65 years,Child-Pugh grade B,tumor diameter≥5 cm,operation time≥120 minutes,preoperative albumin<35 g/L,and comorbid diabetes were significantly associated with post-operative infection(P<0.05).Multivariate logistic regression analysis identified Child-Pugh grade B(OR=2.851,95%CI:1.426-5.698),operation time≥120 minutes(OR=2.367,95%CI:1.238-4.523),and preoperative albumin<35 g/L(OR=2.156,95%CI:1.147-4.052)as independent risk factors for post-operative infection.CONCLUSION Liver function status,operation time,and preoperative albumin level are significant factors affecting post-operative infection in HCC patients undergoing D-TACE.For high-risk patients,enhanced perioperative management,appropriate timing of surgery,and active improvement of nutritional status should be implemented to reduce the risk of post-operative infection. 展开更多
关键词 Hepatocellular carcinoma Drug-eluting trans arterial chemo embolization Post-operative infection Risk factors Retrospective study
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Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis 认领 引用 被引量：5
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作者 Yuntai Yao Hua Ying +2 位作者 Nengxin Fang Yongbao Zhang Xin Yuan 《Chinese Medical Sciences Journal》 CAS CSCD 2020年第2期121-134,共14页
Objective Post-operative cognitive dysfunction(POCD)and post-operative delirium(POD)are two common post-operative cerebral complications.The current meta-analysis was to systematically review the effects of penehyclid... Objective Post-operative cognitive dysfunction(POCD)and post-operative delirium(POD)are two common post-operative cerebral complications.The current meta-analysis was to systematically review the effects of penehyclidine hydrochloride(PHC)on POCD and POD in surgical patients.Methods Electronic databases were searched to identify all randomized controlled trials comparing PHC with atropine/scopolamine/placebo on POCD and POD in surgical patients.Primary outcomes of interest included the incidences of POCD and POD;the secondary outcomes of interest included peri-operative minimental state examination(MMSE)scores.Two authors independently extracted peri-operative data,including patients'baseline characteristics,surgical variables,and outcome data.For dichotomous data(POCD and POD occurrence),treatment effects were calculated as odds ratio(OR)and 95%confidential interval(Cl).Each outcome was tested for heterogeneity,and randomized-effects or fixed-effects model was used in the presence or absence of significant heterogeneity.For continuous variables(MMSE scores),treatment effects were calculated as weighted mean difference(WMD)and 95%CI.Statistical significance was defined as P<0.05.Results Our search yielded 33 studies including 4017 patients.Meta-analysis showed that,the incidence of POCD in PHC group was comparable to that in saline group(OR=0.97;95%Ck 0.S8-1.64;P=0.92),scopolamine group(OR=0.78;95%CI:0.48-1.27;P=0.32)and atropine group(0R=1.20;95%Ch 0.86-1.67;P=0.29).The incidence of POD in PHC group was comparable to that in saline group(OR=1.53;95%CI:0.81-2.90;P=0.19)and scopolamine group(OR=0.53;95%CI:0.06-4.56;P=0.56),but higher than that in atropine group(OR=4.49;95%CI:1.34-15.01;P=0.01).Conclusions PHC premedication was not associated with increased incidences of POCD or POD as compared to either scopolamine or placebo. 展开更多
关键词 penehyclidine hydrochloride post-operative cognitive dysfunction post-operative delirium meta-analysis
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Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein 认领 引用 被引量：26
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作者 Xi-ming LI Ming-tao SHAO +1 位作者 Jian-juan WANG Yue-lan WANG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2014年第10期870-878,共9页
Objective： To investigate the relationship between post-operative cognitive dysfunction（POCD） and regional cerebral oxygen saturation（rSO2） and β-amyloid protein（Aβ） in patients undergoing laparoscopic pancre... Objective： To investigate the relationship between post-operative cognitive dysfunction（POCD） and regional cerebral oxygen saturation（rSO2） and β-amyloid protein（Aβ） in patients undergoing laparoscopic pancreaticoduodenectomy. Methods： Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction（t0）, at the beginning of laparoscopy（t1）, and at the time of pneumoperitoneum 120 min（t2）, pneumoperitoneum 240 min（t3）, pneumoperitoneum 480 min（t4）, the end of pneumoperitoneum（t5）, and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay（ELISA）. Results： Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO2（rSO2, %max） was significantly higher in the POCD group than in the non-POCD group. The rSO2, %max value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values（P〈0.01）. After 24 h, levels of plasma Aβ in the POCD group were significantly higher than those in the non-POCD group（P〈0.01）. Conclusions： The development of POCD in patients undergoing laparoscopic pancreaticoduodenectomy is associated with alterations of rSO2 and Aβ. Monitoring of rSO2 might be useful in the prediction of POCD, and Aβ might be used as a sensitive biochemical marker to predict the occurrence of POCD. 展开更多
关键词 Laparoscopic pancreaticoduodenectomy Regional cerebral oxygen saturation β-Amyloid protein Post-operative cognitive dysfunction
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Perioperative Risk Factors for Post-operative Pneumonia after Type A Acute Aortic Dissection Surgery 认领 引用 被引量：10
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作者 Li-juan HUA Lu-xia KONG +6 位作者 Jian-nan HU Qian LIU Chen BAO Chao LIU Zi-ling LI Jun CHEN Shu-yun XU 《Current Medical Science》 SCIE CAS 2023年第1期69-79,共11页
Objective Type A acute aortic dissection(TAAAD)is a dangerous and complicated condition with a high death rate before hospital treatment.Patients who are fortunate to receive prompt surgical treatment still face high ... Objective Type A acute aortic dissection(TAAAD)is a dangerous and complicated condition with a high death rate before hospital treatment.Patients who are fortunate to receive prompt surgical treatment still face high in-hospital mortality.A series of post-operative complications further affects the prognosis.Post-operative pneumonia(POP)also leads to great morbidity and mortality.This study aimed to identify the prevalence as well as the risk factors for POP in TAAAD patients and offer references for clinical decisions to further improve the prognosis of patients who survived the surgical procedure.Methods The study enrolled 89 TAAAD patients who underwent surgical treatment in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei province,China from December 2020 to July 2021 and analyzed the perioperative data and outcomes of these patients.Logistic regression analyses were used to identify the risk factors for POP.Results In the study,31.5%of patients developed POP.Patients with POP had higher proportions of severe oxygenation damage,pneumothorax,reintubation,tracheotomy,renal replacement therapy,arrhythmia,gastrointestinal bleeding,and longer duration of mechanical ventilation,fever,ICU stay,and length of stay(all with P<0.05).The in-hospital mortality was 2.3%.Smoking,preoperative white blood cells,and intraoperative transfusion were the independent risk factors for POP in TAAAD.Conclusion Patients who underwent TAAAD surgery suffered poorer outcomes when they developed POP.Furthermore,patients with risk factors should be treated with caution. 展开更多
关键词 cardiovascular surgery type A acute aortic dissection post-operative pneumonia risk factors
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Effect of obesity on post-operative outcomes following colorectal cancer surgery 认领 引用 被引量：4
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作者 Derek Mao David E Flynn +3 位作者 Stephanie Yerkovich Kayla Tran Usha Gurunathan Manju D Chandrasegaram 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第7期1324-1336,共13页
BACKGROUND Colorectal cancer(CRC)resection is currently being undertaken in an increasing number of obese patients.Existing studies have yet to reach a consensus as to whether obesity affects post-operative outcomes f... BACKGROUND Colorectal cancer(CRC)resection is currently being undertaken in an increasing number of obese patients.Existing studies have yet to reach a consensus as to whether obesity affects post-operative outcomes following CRC surgery.AIM To evaluate the post-operative outcomes of obese patients following CRC resection,as well as to determine the post-operative outcomes of obese patients in the subgroup undergoing laparoscopic surgery.METHODS Six-hundred and fifteen CRC patients who underwent surgery at the Prince Charles Hospital between January 2010 and December 2020 were categorized into two groups based on body mass index(BMI):Obese[BMI≥30,n=182(29.6%)]and non-obese[BMI<30,n=433(70.4%)].Demographics,comorbidities,surgical features,and post-operative outcomes were compared between both groups.Postoperative outcomes were also compared between both groups in the subgroup of patients undergoing laparoscopic surgery[n=472:BMI≥30,n=136(28.8%);BMI<30,n=336(71.2%)].RESULTS Obese patients had a higher burden of cardiac(73.1%vs 56.8%;P<0.001)and respiratory comorbidities(37.4%vs 26.8%;P=0.01).Obese patients were also more likely to undergo conversion to an open procedure(12.8%vs 5.1%;P=0.002),but did not experience more postoperative complications(51.6%vs 44.1%;P=0.06)or high-grade complications(19.2%vs 14.1%;P=0.11).In the laparoscopic subgroup,however,obesity was associated with a higher prevalence of post-operative complications(47.8%vs 39.3%;P=0.05)but not high-grade complications(17.6%vs 11.0%;P=0.07).CONCLUSION Surgical resection of CRC in obese individuals is safe.A higher prevalence of post-operative complications in obese patients appears to only be in the context of laparoscopic surgery. 展开更多
关键词 Colorectal cancer Obesity Body mass index Post-operative outcomes Clavien-Dindo
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Post-operative abdominal complications in Crohn's disease in the biological era:Systematic review and meta-analysis 认领 引用 被引量：4
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作者 Peter Waterland Thanos Athanasiou Heena Patel 《World Journal of Gastrointestinal Surgery》 2016年第3期274-283,共10页
AIM:To perform a systematic review and meta-analysis on post-operative complications after surgery for Crohn's disease(CD)comparing biological with no therapy.METHODS:Pub Med,Medline and Embase databases were sear... AIM:To perform a systematic review and meta-analysis on post-operative complications after surgery for Crohn's disease(CD)comparing biological with no therapy.METHODS:Pub Med,Medline and Embase databases were searched to identify studies comparing postoperative outcomes in CD patients receiving biological therapy and those who did not.A meta-analysis with a random-effects model was used to calculate pooled odds ratios(OR)and confidence intervals(CI)for each outcome measure of interest.RESULTS:A total of 14 studies were included for metaanalysis,comprising a total of 5425 patients with CD 1024(biological treatment,4401 control group).After biological therapy there was an increased risk of total infectious complications(OR=1.52;95%CI:1.14-2.03,8 studies)and wound infection(OR=1.73;95%CI:1.12-2.67;P=0.01,7 studies).There was no increased risk for other complications including anastomotic leak(OR=1.19;95%CI:0.82-1.71;P=0.26),abdominal sepsis(OR=1.22;95%CI:0.87-1.72;P=0.25)and re-operation(OR=1.12;95%CI:0.81-1.54;P=0.46)in patients receiving biological therapy.CONCLUSION:Pre-operative use of anti-TNF-αtherapy may increase risk of post-operative infectious complications after surgery for CD and in particular wound related infections. 展开更多
关键词 Crohn's Post-operative complications Biological Anti-tumor necrosis factor-α Monoclonal antibody Infliximab Adulimimab
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Cost-effectiveness of Crohn's disease post-operative care 认领 引用 被引量：1
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作者 Emily K Wright Michael A Kamm +7 位作者 Peter Dr Cruz Amy L Hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny Liew 《World Journal of Gastroenterology》 SCIE CAS 2016年第14期3860-3868,共9页
AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn&#x02019;s disease following intestinal resection.METHODS: In the &#x020... AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn&#x02019;s disease following intestinal resection.METHODS: In the &#x0201c;POCER&#x0201d; study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care (6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin (FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 mo.RESULTS: Sixty patients (active care n = 43, standard care n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those in remission [$26347 (IQR 25045-27485) vs $2729 (IQR 1182-5215), P &#x0003c; 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence prevented.CONCLUSION: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated. 展开更多
关键词 Crohn’ s disease Post-operative Health economics Health care cost Biologics
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Effectiveness of massage therapy on post-operative outcomes among patients undergoing cardiac surgery:A systematic review 认领 引用 被引量：1
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作者 C.Ramesh Vasudev Baburaya Pai +4 位作者 Nitin Patil Baby S.Nayak Anice George Linu Sara George Elsa Sanatombi Devi 《International Journal of Nursing Sciences》 2015年第3期304-312,共9页
The incidence and prevalence of cardiovascular disease(CVD)are increasing rapidly in developing countries.Most patients with CVD do not respond to medical treatment and have to undergo cardiac surgery.This highly stre... The incidence and prevalence of cardiovascular disease(CVD)are increasing rapidly in developing countries.Most patients with CVD do not respond to medical treatment and have to undergo cardiac surgery.This highly stressful experience results in increased levels of anxiety for patients.The objective of this review was to evaluate the efficacy of massage therapy on postoperative outcomes among patients undergoing cardiac surgery.A comprehensive literature search was made on PubMed-Medline,CINAHL,Science Direct,Scopus,Web of Science and the Cochrane library databases for original research articles published between 2000 and 2015.Original articles that reported the efficacy of massage therapy in patients undergoing cardiac surgery were included.The Cochrane data extraction form was used to extract data.A total of 297 studies were identified in the literature search.However,only seven studies were eligible for analysis.Of the seven studies,six studies demonstrated the effects of massage therapy on improving postoperative outcomes of patients,while one study found no evidence of improvement.Although the methods varied considerably,most of the studies included in this review reported positive results.Therefore,there is some evidence that massage therapy can lead to positive postoperative outcomes.Evidence of the effectiveness of massage therapy in patients undergoing cardiac surgery remains inconclusive.Additional research is needed to provide a strong evidence base for the use of massage therapy to improve post-operative outcomes and recovery among cardiac surgery patients. 展开更多
关键词 Anxiety Heart surgery Massage Pain Post-operative period
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Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease 认领 引用 被引量：2
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作者 Tauseef Ali Laura Yun David T Rubin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第3期197-204,共8页
There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with... There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn' s disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Studyresults could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed. 展开更多
关键词 Crohn＇s disease Ulcerative colitis Colectomy Post-operative complications
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Effect of ankle versus thigh tourniquets on post-operative pain in foot and ankle surgery 认领 引用 被引量：2
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作者 Ashish Mishra Ahmed Barakat +5 位作者 Jitendra Mangwani Jakub Kazda Sagar Tiwatane Sana Mohammed Aamir Shaikh Linzy Houchen-Wolloff Vipul Kaushik 《World Journal of Orthopedics》 2024年第2期163-169,共7页
BACKGROUND Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss,improve visualization in the surgical field,and to potentially reduce surgical time.There is a lack of consensus ... BACKGROUND Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss,improve visualization in the surgical field,and to potentially reduce surgical time.There is a lack of consensus in existing guidelines regarding the optimal tourniquet pressure,placement site,and duration of use.There is a paucity of data on the relationship between the site of a tourniquet and postoperative pain in foot and ankle surgery.AIM To explore the relationship between tourniquet site and intensity of post-operative pain scores in patients undergoing elective foot and ankle surgery.METHODS Retrospective analysis of prospectively collected data on 201 patients who underwent foot and ankle surgery in a single institution was undertaken.Intraoperative tourniquet duration,tourniquet pressure and site,and postoperative pain scores using Visual Analogue Score were collected in immediate recovery,at six hours and at 24 h post-op.Scatter plots were used to analyse the data and to assess for the statistical correlation between tourniquet pressure,duration,site,and pain scores using Pearson correlation coefficient.RESULTS All patients who underwent foot and ankle surgery had tourniquet pressure of 250 mmHg for ankle tourniquet and 300 mmHg for thigh.There was no correlation between the site of the tourniquet and pain scores in recovery,at six hours and after 24 h.There was a weak correlation between tourniquet time and Visual Analogue Score immediately post-op(r=0.14,P=0.04)but not at six or 24 h post-operatively.CONCLUSION This study shows that there was no statistically significant correlation between tourniquet pressure,site and postop pain in patients undergoing foot and ankle surgery.The choice of using a tourniquet is based on the surgeon's preference,with the goal of minimizing the duration of its application at the operative site. 展开更多
关键词 Lower limb surgery Tourniquet time Tourniquet pressure Tourniquet site Post-operative pain Pain scores
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Association between anterior internal fixation systems and post-operative lateral angulation in thoracolumbar fractures 认领 引用
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作者 马立泰 《外科研究与新技术（中英文）》 2011年第2期106-106,共1页
Objective To explore the effects of the anterior internal fixation systems on the post-operative lateral angulation in treatment of thoracolumbar fractures.Methods A retrospective study was done to analyze the 172 pat... Objective To explore the effects of the anterior internal fixation systems on the post-operative lateral angulation in treatment of thoracolumbar fractures.Methods A retrospective study was done to analyze the 172 patients who had 展开更多
关键词 Association between anterior internal fixation systems and post-operative lateral angulation in thoracolumbar fractures
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Value of helical CT volume rendering technique in post-operative evaluation of screw in screw fixation of axis fractures 认领 引用
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作者 许崇永 《外科研究与新技术（中英文）》 2005年第3期173-173,共1页
To explore the value of helical CT volume rendering technique (VRT) in post-operative evaluation of screw fixation of axis fractures.Methods There were 21 cases of screw fixation of axis fractures between February 200... To explore the value of helical CT volume rendering technique (VRT) in post-operative evaluation of screw fixation of axis fractures.Methods There were 21 cases of screw fixation of axis fractures between February 2002 and May 2004 in the study including six cases with fractures on axis body,five on odontoid process and 10 on axis body and odontoid process.All cases received X-ray plain film,helical CT scanning,multi-planar reformatting(MPR) and VRT.Results Screw fixation through axis body and massa lateralis atlantis was performed in 10 cases and that through axis body and odontoid process in 11.VRT could clearly display full aperture of screw orbit,location of screw and angle of fixation and hence was superior to X-ray plain film and MPR.Multi-angle VRT displayed asymmetrical space of odontoid process and massa lateralis atlantis in four cases and medial deviation of 2～5 mm of half screw in screw fixation through axis body and massa lateralis atlantis in six.Conclusion VRT can eliminate false shadow of fixation screw,clearly display full aperture of screw orbit and hence supply improtant imaging evidence for post-operative evaluation of screw fixation of axis fractures.7 refs,1 fig,1 tab. 展开更多
关键词 Value of helical CT volume rendering technique in post-operative evaluation of screw in screw fixation of axis fractures
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Modeling Post-Operative Cognitive Dysfunction in Zebrafish 认领 引用 被引量：1
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作者 Bill J. McElroy Julie L. Mustard +3 位作者 Syed Kamran Catherine P. Jung Katie L. Bakken Norbert W. Seidler 《Advances in Alzheimer's Disease》 CAS 2016年第3期126-141,共16页
Permanent post-operative cognitive dysfunction (POCD) is a grim outcome to an estimated 6% of elderly surgical patients. Volatile anesthetics impact neuronal tissue independent of effects attributed to the physical tr... Permanent post-operative cognitive dysfunction (POCD) is a grim outcome to an estimated 6% of elderly surgical patients. Volatile anesthetics impact neuronal tissue independent of effects attributed to the physical trauma of the surgery itself. While it is recognized that all aspects related to surgery may contribute to cognitive loss in some manner, the present paper focuses on the role of volatile anesthetics in promoting POCD. There is an increased risk of onset and progression of Alzheimer’s disease (AD) from POCD, implying that the neuropathogenesis between the two is similar. Human studies, being ethically limited in scope, require animal models as a substitute. While the literature using rodent models contains valuable information, we believe that the accessible and practical zebrafish will greatly enhance our further understanding of the molecular mechanism of POCD as it relates to AD. Disease genes and fundamental neurobehaviors of these teleost fish mirror those of mammals and humans, validating their use as a core research model for AD. Since the gradual senescence seen in zebrafish also resembles that found in humans, we numerically correlated the two lifespans, offering researchers a computational tool. Zebrafish, being aquatic animals, necessitates the use of miscible compounds, such as trifluoroethanol, whose anesthetic potency we are presenting. We also review the rodent and zebrafish literature relevant to POCD. Continued research with the leading-edge zebrafish unlocks the possibility that, in the future, perioperative intervention will prevent POCD. 展开更多
关键词 Zebrafish Post-Operative Cognitive Dysfunction Dementia Aging Anesthesia
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Predictors and prognostic impact of post-operative atrial fibrillation in patients with hip fracture surgery 认领 引用
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作者 Seong Jun Bae Chang Hee Kwon +4 位作者 Tae-Young Kim Haseong Chang Bum Sung Kim Sung Hea Kim Hyun-Joong Kim 《World Journal of Clinical Cases》 SCIE 2022年第11期3379-3388,共10页
BACKGROUND Atrial fibrillation(AF)is the most common arrhythmia developing in postoperative patients.Limited data are available regarding pre-operative risk factors and prognostic impact of post-operative AF(POAF)foll... BACKGROUND Atrial fibrillation(AF)is the most common arrhythmia developing in postoperative patients.Limited data are available regarding pre-operative risk factors and prognostic impact of post-operative AF(POAF)following hip fracture surgery(HFS)in Korean population.AIM We aimed to investigate the incidence,predictors,and hospital prognosis of POAF in HFS patients.METHODS This study included 245 patients without history of AF who underwent HFS between August 2014 and November 2016.POAF was defined as new-onset AF that occurred during hospitalization after HFS.RESULTS Twenty patients(8.2%)experienced POAF after HFS.POAF developed on median post-operative day 2(interquartile range,1–3).Multivariable logistic regression analysis showed that age[odds ratio(OR),1.111;95%confidence interval(CI),1.022–1.209],chronic obstructive pulmonary disease(COPD)(OR,6.352;95%CI,1.561–25.841)and E/e’ratio(OR,1.174;95%CI,1.002–1.376)were significant predictors of POAF.Patients with POAF had a significantly higher intensive care unit admission rate(55.0%vs 14.7%,P<0.001)and incidence of congestive heart failure(45.0%vs 10.7%,P<0.001).In multivariable logistic regression analysis,POAF was significantly associated with increased incidence of congestive heart failure(OR,4.856;95%CI,1.437–16.411)and intensive care unit admission(OR,6.615;95%CI,2.112–20.718).CONCLUSION POAF was frequently developed in elderly patients following HFS.Age,COPD and elevated E/e’ratio were found as significant predictors of POAF in HFS patients.Patients with POAF significantly experienced intensive care unit admission and incident congestive heart failure during hospitalization. 展开更多
关键词 Atrial fibrillation Post-operative Predictor Prognosis Hip fracture surgery
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Evaluation of Post-Operative Atrial Fibrillation after Cardiac Surgery for Adult Congenital Heart Disease 认领 引用
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作者 Jonathan S.Taylor-Fishwick Nicholas Holzemer +5 位作者 Brandon Middlemist Vivian Duarte Kaitlin E.Olson Johannes Cvon Alvensleben Megan SooHoo Amber Khanna 《Congenital Heart Disease》 SCIE 2024年第5期457-472,共16页
Background:Post-operative atrial fibrillation(POAF)frequently occurs after cardiac surgery.Although adult congenital heart disease(ACHD)patients have higher rates of arrhythmia than the general population,there is sca... Background:Post-operative atrial fibrillation(POAF)frequently occurs after cardiac surgery.Although adult congenital heart disease(ACHD)patients have higher rates of arrhythmia than the general population,there is scant literature on POAF in ACHD patients.Objectives:Identify key risk factors associated with post-operative atrial fibrillation and evaluate the short-and mid-term significance of developing POAF.Methods:A retrospective cohort study was conducted of ACHD patients from 2013–2021 at the University of Colorado Hospital and Children’s Hospital of Colorado.The institutional Society of Thoracic Surgeons(STS)surgical registry was used to identify patients≥18-year-old with congenital heart disease who underwent cardiac surgery during the study period.Results:A total of 168 patients(48%female)were included.The median age was 36 years(IQR 28–48).Onehundred and fifty patients(90%)had moderate ACHD anatomical complexity,and 10 patients(6%)had severe ACHD anatomical complexity based on initial ACHD diagnosis.POAF occurred in 40(24%)patients.Older age,history of supraventricular tachycardia,intra-operative arrhythmia,and post-operative hypokalemia independently predicted POAF.POAF was associated with an increased length of stay(8 vs.5 days,p<0.001)and recurrence of atrial fibrillation(46%vs.21%,OR 3.35,p=0.002)but did not predict mortality,stroke,or bleeding event.Conclusion:Atrial fibrillation is a common complication after cardiac surgery in the ACHD population.Older age,history of supraventricular tachycardia,intra-operative arrhythmia,and post-operative hypokalemia independently predicted POAF.Further investigation is needed to understand the long-term impacts of POAF. 展开更多
关键词 Atrial fibrillation adult congenital heart disease cardiac surgery post-operative complications
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Correlation linking illness perception,negative emotions,and the post-operative recovery effect in patients with perianal disease 认领 引用 被引量：3
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作者 Shu-Xiang Hou Feng-Jun Dai +2 位作者 Xian-Xue Wang Shao-Wen Wang Ting Tian 《World Journal of Psychiatry》 SCIE 2024年第11期1718-1727,共10页
BACKGROUND Improvements in the standard of living have led to increased attention to perianal disease.Although surgical treatments are effective,the outcomes of postoperative recovery(POR)are influenced by various fac... BACKGROUND Improvements in the standard of living have led to increased attention to perianal disease.Although surgical treatments are effective,the outcomes of postoperative recovery(POR)are influenced by various factors,including individual differences among patients,the characteristics of the disease itself,and the psychological state of the patient.Understanding these factors can help healthcare providers develop more personalized and effective post-operative care plans for patients with perianal disease.AIM To investigate the effect of illness perception(IP)and negative emotions on POR outcomes in patients with perianal disease.METHODS A total of 146 patients with perianal disease admitted to the First People's Hospital of Changde City from March to December 2023 were recruited.We employed a general information questionnaire,the Brief Illness Perception Questionnaire(B-IPQ),and the Hospital Anxiety and Depression Scale(HADS).We used the 15-item Quality of Recovery Score(QoR-15)to measure patients’recovery effects.Finally,we conducted Pearson’s correlation analysis to examine the relationship between pre-operative IP and anxiety and depression levels with POR quality.RESULTS Fifty-three(36.3%)had poor knowledge of their disease.Thirty(20.5%)were suspected of having anxiety and 99(67.8%)exhibited symptoms.Forty(27.4%)were suspected of having depression and 102(69.9%)displayed symptoms.The B-IPQ,HADS-A,HADS-D,and QoR-15 scores were 46.82±9.97,12.99±3.60,12.58±3.36,and 96.77±9.85,respectively.There was a negative correlation between pre-operative IP,anxiety,and depression with POR quality.The influence of age and disease course on post-operative rehabilitation effect are both negative.The impact of B-IPQ,HADS-A,and HADS-D on POR was negative.Collectively,these variables accounted for 72.6%of the variance in POR.CONCLUSION The quality of POR in patients with perianal disease is medium and is related to age,disease course,IP,anxiety,and depression. 展开更多
关键词 Illness perception anxiety Depression Crissum disease/perianal disease Post-operative recovery Relativity
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Early Post-Operative Complications in Surgeries Pertaining Oral and Maxillofacial Region in MNH, Tanzania 认领 引用 被引量：2
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作者 Karpal Singh Sohal Farid Shubi 《Surgical Science》 2015年第10期470-477,共8页
The Oral and maxillofacial region is one of the complex regions of the body considering the vast anatomical structures that are found in this region;head and neck surgery has potential for many complications, yet inad... The Oral and maxillofacial region is one of the complex regions of the body considering the vast anatomical structures that are found in this region;head and neck surgery has potential for many complications, yet inadequate information on occurrence of post-operative complications in oral and maxillofacial surgeries in our setting has been documented. The aim of this study was to determine the occurrence of common early post-operative complications after oral and maxillofacial surgery in relationship to the underlying systemic condition. A descriptive postoperative study was done whereby patients who underwent oral and maxillofacial surgery were included. The included patients were those who underwent surgery for different pathological conditions, trauma, developmental/congenital conditions and inflammatory conditions to mention few. Demographic data, complications developed within one week post operative, and underlying systemic comorbidities before and after surgery were documented and analysed. A total of 102 patients were included in the study. The mean age of participants was 30.00 ± 17.01 years with a range of 2 to 81 years. Majority 43.1% (n = 44) had benign tumors with a leading diagnosis of ameloblastoma. In general, the most common complications which were noted in the cases included Pain 98% (n = 100) and Post-operative Swelling 97.1% (n = 99). The presence of underlying systemic comorbid conditions has a significant role in occurrence of some severe complications. The occurrence of complications does increase the duration of stay in the hospital hence increasing cost of treatment for which bearers are both patients and the hospital. 展开更多
关键词 Early Post-Operative Complication Oral and Maxillofacial Surgery Systemic Conditions
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