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Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation:A randomized controlled trial 认领 引用
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作者 Wei-Min Li Xiao-Peng Wang +4 位作者 Yu-Xuan Li Yi-Dong Wang Yi-Jie Sun Guo-Dong Li Jia-Qi Wu 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第6期339-346,共8页
BACKGROUND Adequate bowel preparation is fundamental for colonoscopy.The traditional strategy of 3 L polyethylene glycol(PEG)is often unsatisfactory for people at high risk of inadequate bowel preparation(HR-IBP).AIM ... BACKGROUND Adequate bowel preparation is fundamental for colonoscopy.The traditional strategy of 3 L polyethylene glycol(PEG)is often unsatisfactory for people at high risk of inadequate bowel preparation(HR-IBP).AIM To evaluate bowel preparation quality and adverse events associated with 3 L PEG combined with linaclotide in the HR-IBP population.METHODS This single-center,endoscopist-blinded,randomized controlled trial enrolled patients scheduled for colonoscopy.A total of 167 patients were randomly allocated to either the 3 L PEG group or the 3 L PEG plus linaclotide group.The quality of bowel preparation was assessed using the Boston bowel preparation scale(BBPS).The adenoma detection rate(ADR),polyp detection rate(PDR),polyp characteristics,and adverse events were also analyzed.RESULTS BBPS scores were significantly higher in the 3 L PEG plus linaclotide group than in the 3 L PEG alone group(6.800±1.444 vs 5.593±1.579,P<0.001).The adequate bowel preparation rate was also markedly higher in the 3 L PEG plus linaclotide group(86.250%vs 58.025%,P<0.001).ADR,PDR,polyp characteristics,and adverse events were comparable between the groups.CONCLUSION The combination of 3 L PEG and linaclotide is optimal for bowel cleansing in high-risk cohorts. 展开更多
关键词 Linaclotide Bowel preparation High-risk patients Boston bowel preparation scale Adequate preparation rate
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Methods of preparation,structural characteristics of resistant starch and its relation to human health:a review 认领 引用 被引量：1
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作者 Weiyi Zhang Yang Yang +6 位作者 Chunmin Ma Bing Wang Xiaofei Liu Yan Wang Xin Bian Guang Zhang Na Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1503-1519,共17页
Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromo... Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromoting ingredients that can regulate blood glucose and lipid levels,prevent cancer,and enhance the quality of life.Consequently,new technologies for the preparation of RS are continually being developed to support its industrial production.This review describes the structural and nutritional properties of RS and examines recent advancements in RS preparation methods.Emphasis is placed on how RS structure influences its properties and the physiological mechanisms in vivo.This review aims to stimulate further research into the preparation methods,functional characteristics,and utilization of RS,thereby supporting ongoing developments in the food industry. 展开更多
关键词 Resistant starch Preparation methods Characterization Function Human health
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Efficacy and safety of a novel sodium picosulfate oral tablet in a randomized controlled trial for bowel preparation 认领 引用 被引量：1
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作者 Su Bum Park Sang Bum Kang +12 位作者 Geom Seog Seo Chang Soo Eun Chang Hwan Choi Dong-Hoon Yang Jae Jun Park Chang Mo Moon Sung Hoon Jung Hyung Park Mi Hee Park Ho Kyun Yoo Jiwon Kim Jung A Heo Dong Il Park 《World Journal of Gastroenterology》 SCIE CAS 2026年第6期57-66,共10页
BACKGROUND Oral sulfate tablets(OSTs)are commonly used in South Korea,but the requirement to ingest 28 tablets and concerns regarding renal and gastrointestinal safety may reduce patient compliance.DWJ1609 is a novel ... BACKGROUND Oral sulfate tablets(OSTs)are commonly used in South Korea,but the requirement to ingest 28 tablets and concerns regarding renal and gastrointestinal safety may reduce patient compliance.DWJ1609 is a novel OST formulation that contains sodium picosulfate and 25%less sulfate,requiring only 20 tablets.This modification is expected to improve tolerability while maintaining cleansing efficacy.AIM To evaluate the bowel cleansing efficacy and safety of DWJ1609 compared with conventional OSTs and to assess adverse events.METHODS This prospective,randomized,single-blinded(investigator),multicenter,phase III clinical trial was conducted at seven university hospitals in South Korea.The primary endpoint was the non-inferiority of DWJ1609 based on the proportion of participants achieving a“successful”grade A or B on the Harefield Cleansing Scale,as assessed by independent central readers.Safety was monitored through adverse events and laboratory evaluations.RESULTS Overall,215 participants were randomized,and 200 were included in the per-protocol analysis(DWJ1609:99;OST:101).Successful bowel cleansing was achieved in 96.97% of the DWJ1609 group,which was non-inferior to the OST group(100.00%),with a difference of 3.03%.DWJ1609 showed significantly higher tolerability,with lower incidence of nausea,headache,and dizziness,although vomiting occurred slightly more frequently.CONCLUSION DWJ1609 demonstrated non-inferior bowel cleansing efficacy,improved tolerability,and a favorable safety profile compared with conventional.DWJ1609 has the potential to improve compliance and overall quality of colonoscopy. 展开更多
关键词 DWJ1609 Sodium picosulfate Oral sulfate tablets Bowel preparation Colon cleansing
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Recent advances and future challenges in intelligent refractory materials:design principles,preparation technologies,and industrial applications 认领 引用
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作者 Yan-Lin Li Xiao-Yuan Wan +3 位作者 Nan Jiang Xin-Yao Qi Dong-Hai Ding Guo-Qing Xiao 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2026年第1期299-310,共12页
Intelligent refractory materials represent a new generation of high-temperature functional materials that significantly enhance the service performance of traditional refractories in extreme environments through integ... Intelligent refractory materials represent a new generation of high-temperature functional materials that significantly enhance the service performance of traditional refractories in extreme environments through integrated sensing,response,and adaptive mechanisms.A comprehensive overview of intelligent refractory materials was provided,focusing on their classification,preparation techniques,and industrial applications.Firstly,the categories and design principles of intelligent refractory materials are introduced,including self-healing,self-regulating,and self-diagnosing types,which enhance durability and performance under extreme conditions.Subsequently,advanced preparation technologies are discussed,such as 3D printing for complex geometries,nanocomposite engineering for improved mechanical and thermal properties,gradient design for optimized thermal stress resistance and information technology including machine learning,health monitoring,digital twin.Finally,the industrial applications of these materials are highlighted,particularly in steel metallurgy,building materials industry,and energy.It aims to bridge the gap between research advancements and practical implementation,offering insights into future trends in intelligent refractory material development. 展开更多
关键词 Intelligent refractory material Self-healing Self-regulating Self-diagnosing Preparation technology
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Melting Preparation for Tungsten-Doped Graphene/Copper Composites 认领 引用
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作者 Yunzhong Wu Changsheng Xing +7 位作者 Tong Zhang Jiaxu Shuang Deyu Zhang Jie Li Miao Wang Jie Sheng Lidong Wang Weidong Fei 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期638-654,共17页
Melting production plays a pivotal role in the modern copper industry.However,applying this process to fabricate nanocarbon(e.g.,graphene,carbon nanotubes)-reinforced copper matrix composites has remained a long-stand... Melting production plays a pivotal role in the modern copper industry.However,applying this process to fabricate nanocarbon(e.g.,graphene,carbon nanotubes)-reinforced copper matrix composites has remained a long-standing challenge for nearly 2 decades.In this study,a melting preparation strategy for Graphene-Cu(Gr/Cu)composites was developed by introducing tungsten-doped graphene(W-Gr)into molten Cu,effectively improving the wettability and density compatibility between graphene(Gr)and molten Cu.The contact angle between W-Gr and molten Cu decreases to 80.4°,while the density of W-Gr increases to 9.5 g cm-3.W-Gr sheets containing 13 at%and 18 at%tungsten(designated as 13W-Gr and 18W-Gr)disperse uniformly within the Cu matrix.Thermodynamic analysis indicates that W-Gr can spontaneously disperse in molten Cu when the surface area fraction of WC on W-Gr exceeds 45.8%.The ultimate tensile strength(UTS)of 13W-Gr/Cu reaches 152 MPa in the as-cast state and 449 MPa after cold rolling.The electrical conductivity of 13W-Gr/Cu reaches 100.4%international annealed copper standard(IACS)at 20℃,and is 1.5%higher than that of pure Cu at 180℃.This work overcomes the challenges of fabricating Gr/Cu composites via the melting process,provides a viable approach for their large-scale industrial production. 展开更多
关键词 electrical conductivities graphene/copper composites melting preparation tungsten-doped graphene wettability
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Study on the preparation principle and strengthening mechanism of in-situ synthesized Mg-Li matrix composites through the La2O3→La→AlmLanroute 认领 引用
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作者 Xiaoqiang Li Xinlian He +5 位作者 Junze Zhang Daohe Zhang Dandan Li Qichi Le Jinhui Wang Dexue Liu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2026年第6期505-520,共16页
In this study,low-cost La2O3powder modified with LiF-LiCl flux was used as a precursor and introduced into Mg-5Li-3Al-2Zn(LAZ532)alloy melt.Through a series of reactions,in-situ formed AlmLanphase-reinforc... In this study,low-cost La2O3powder modified with LiF-LiCl flux was used as a precursor and introduced into Mg-5Li-3Al-2Zn(LAZ532)alloy melt.Through a series of reactions,in-situ formed AlmLanphase-reinforced LAZ532 matrix composites were successfully prepared.The surface modification of La2O3powder by molten salt and the related reduction reaction mechanism in the alloy melt,as well as the effects of different La2O3additions on the microstructure and mechanical properties of the composites,were systematically investigated.First-principles calculations revealed that during precursor preparation,the Cl/F heteroatoms in the flux chemically destabilize La-O bonds,forming LaOF/LaOCl intermediates.Subsequently,Li atoms with low electronegativity and high reactivity in the melt preferentially combined with O/Cl/F,driving the reduction reactions.The reduced La then preferentially bonded with Al,predominantly forming the stable Al3La phase,along with small amounts of Al11La3 and Al2La phases.Microstructural analysis showed that as the La2O3content increased from 0.3%to 2.0 wt.%,the yield rate of La in the composite rose from 8%to 23%.Furthermore,the dispersed microano-sized AlmLanphases formed an atomically bonded interface with the matrix,and their size initially decreased and then slightly increased with increasing volume fraction.These phases promoted recrystallization through heterogeneous nucleation and grain boundary pinning,leading to texture weakening and grain refinement in the composites.The mechanical properties of the composites first improved and then deteriorated with increasing La2O3addition.Among them,the composite with 0.7 wt.%La2O3exhibited excellent comprehensive mechanical properties,with tensile strength,yield strength,and elongation reaching 278.3 MPa,182.5 MPa,and 23.6%,respectively.The enhancement in yield strength was mainly attributed to the synergistic effects of grain refinement,precipitation strengthening,and texture strengthening.This study offers a novel design concept for in-situ synthesized Mg-Li matrix composites,holding significant scientific value. 展开更多
关键词 Mg-Li matrix composites La2O3powder In situ synthesis Preparation principle Strengthening mechanism
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Preparation Process and Performance Evaluation of Terminal Blend Composite-modified Asphalt 认领 引用
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作者 YUAN Yan WANG Yefei +2 位作者 CHEN Hongyu XU Song ZHENG Zhidong 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第1期200-209,共10页
To explore the best preparation process for terminal blend(TB)composite-modified asphalt and to filter its formulation with excellent performance,this study evaluates the performance of TB composite modified asphalt b... To explore the best preparation process for terminal blend(TB)composite-modified asphalt and to filter its formulation with excellent performance,this study evaluates the performance of TB composite modified asphalt by physical property index,microscopic morphology,rheological testing,and infrared spectroscopy on multiple scales.The results show that the best preparation process for TB-modified asphalt is stirring at 260℃ for 4 h at 400 rpm,which significantly reduces the modification time of the asphalt.From a physical property viewpoint,the TB composite-modified asphalt sample with 5% styrene-butadiene-styrene(SBS)+1% aromatics+0.1% sulfur exhibits high-comprehensive,high-and low-temperature properties.More-over,its crosslinked mesh structure comprises black rubber particles uniformly interwoven in the middle,which further enhances the performance of the asphalt and results in an excellent performance formulation.In addition,the sample with 5%SBS content has a higher G*value and smaller δ value than that with 3%SBS content,indicating that its high-temperature resistance is improved.The effect of adding 3%SBS content on the viscoelastic ratio is,to some extent,less than that caused by 20% rubber powder. 展开更多
关键词 road engineering terminal blend rubberized asphalt preparation process modification mechanism
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Letter to the Editor:Probiotics counteract polyethylene glycol bowel preparation dysbiosis and infection risk 认领 引用
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作者 Yang Fu 《World Journal of Gastroenterology》 SCIE CAS 2026年第28期157-160,F0003,共4页
Polyethylene glycol(PEG)bowel preparation,though widely used,can significantly disrupt gut microbiota composition.Kou et al recently published study in the World Journal of Gastroenterology,which demonstrated that PEG... Polyethylene glycol(PEG)bowel preparation,though widely used,can significantly disrupt gut microbiota composition.Kou et al recently published study in the World Journal of Gastroenterology,which demonstrated that PEG-treated mice challenged with Citrobacter rodentium exhibit higher pathogen loads,elevated virulence gene expression,and worsened colitis,mediated by microbiota dysbiosis.Importantly,Lactobacillus acidophilus supplementation restored microbial balance and mitigated infection severity,suggesting PEG-induced loss of colonization resistance exposes a 14-day infection window.This paradigm aligns with a rare human case of septic shock after PEG bowel preparation,highlighting potential opportunistic infection risk.Probiotic Lactobacillus strengthen the epithelial barrier and modulate immunity,and clinical trials support their efficacy and safety in gastrointestinal contexts.We discuss the translational significance of these findings and advocate microbiota-protective strategies(probiotic supplementation,optimal timing of endoscopy,and dietary adjustments)during bowel preparation. 展开更多
关键词 Polyethylene glycol Bowel preparation Dysbiosis Citrobacter rodentium Probiotics Colonoscopy Infection risk
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Recent advances in biomass-based monolithic carbon materials:Preparation and energy,environment applications 认领 引用
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作者 Yuzhu Yang Runqing Wang +7 位作者 Pengchen Wang Long Shi Zhongde Dai Junfeng Zheng Lu Yao Dengrong Sun Wenju Jiang Lin Yang 《Green Energy & Environment》 SCIE EI CAS CSCD 2026年第4期968-994,共27页
Biomass-derived carbon materials(BC)have demonstrated significant promise in fields such as adsorbents,catalysts/catalyst supports,energy storage,and gas storage due to their versatile properties such as developed por... Biomass-derived carbon materials(BC)have demonstrated significant promise in fields such as adsorbents,catalysts/catalyst supports,energy storage,and gas storage due to their versatile properties such as developed pore structure,outstanding electrical conductivity,and mechanical stability.In recent years,biomass-derived monolithic carbon materials(BMC)have garnered increasing attention.By overcoming the limitations of traditional powdered BC materials―such as operational difficulties,high usage losses,and safety concerns,thus significantly expanding the research scope of BC.In this paper,the recent advances in BMC materials,including their synthesis strategy and applications in energy storage(such as electrochemical catalysis)and environmental remediation(pollution control,carbon capture,etc.),are comprehensively reviewed for the first time.At last,the remaining challenges and new outlooks on the research of BMC have also been proposed.It is expected that this review paper would assist the reader working on BMC and interested newcomers to acquire concise and systematic information as well as contribute novel ideas over a wide spectrum of disciplines. 展开更多
关键词 Biomass Monolithic carbon Preparation Energy storage Environment remediation
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Preparation of TiO2-xVia Inorganic Chemical Reduction Method and its Applications in Solar-Driven Photothermal Water Evaporation:Progress and Prospects 认领 引用
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作者 Ting Wang Shilong Yu +3 位作者 Chunli Wang Xuepeng Yin Hao Niu Shanmin Gao 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2026年第1期498-518,共21页
Global water scarcity and pollution present critical challenges for human society.Solar-driven wastewater treatments,such as photocatalytic degradation of organic pollutants and photothermal conversion water evaporati... Global water scarcity and pollution present critical challenges for human society.Solar-driven wastewater treatments,such as photocatalytic degradation of organic pollutants and photothermal conversion water evaporation,offer promising solutions.TiO2has garnered extensive attention in these fields,but its large bandgap limits light absorption,affecting its performance and broader applications in energy and environmental fields.Consequently,modifying TiO2to improve its photocatalytic and photothermal conversion performance has become a research hotspot.Among various modification strategies,self-doping with Ti3+and oxygen vacancies can reduce the bandgap of TiO2,improve sunlight utilization,and increase the separation efficiency of photogenerated electron-hole pairs,thereby significantly enhancing the photocatalytic and photothermal conversion performance.This review focuses on the inorganic chemical reduction methods for preparing Ti3+/oxygen vacancies self-doped TiO2and their current applications in solar-driven photothermal conversion water evaporation.It highlights the challenges faced during synthesis and application while offering insights into future development prospects.This review is expected to provide a valuable reference for further research on the preparation and application of Ti3+/oxygen vacancies self-doped TiO2. 展开更多
关键词 application oxygen vacancies photothermal conversion preparation self-doped TiO2
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A novel drill-milling technology for robot-assisted implant osteotomy preparation:simulation and an ex vivo validation study 认领 引用
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作者 Chaofan LI Kangjie CHENG +3 位作者 Chenhao YU Russell WANG Fudong ZHU Yunfeng LIU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2026年第8期906-917,I0023,共12页
Objective:Excessive frictional heat generated at the drill–bone interface during implant osteotomy can compromise osseointegration and lead to implant failure.This study’s objective was to use a helical milling tech... Objective:Excessive frictional heat generated at the drill–bone interface during implant osteotomy can compromise osseointegration and lead to implant failure.This study’s objective was to use a helical milling technique for dental implant osteotomy preparation to mitigate thermal damage to the bone.Methods:This study introduces a novel helical milling technique designed to minimize thermal damage to bone during dental implant osteotomy preparations.Finite element simulations were conducted to compare the thermal distribution and cutting stress of a conventional twist drill and the newly designed helical drill.The experimental validation was performed ex vivo on animal bone using a robot-assisted osteotomy system.Results:The finite element simulations revealed that the helical drill produced a maximum cutting stress of 128.9 MPa,higher than the 121.0 MPa generated by the twist drill,indicating improved cutting efficiency.The ex vivo study demonstrated that the helical milling technique maintained the drilling site temperature below 38.7℃,which was significantly lower than the clinically critical threshold of 47℃and the 61℃recorded with the twist drill.Furthermore,the helical milling process facilitated efficient bone chip removal,reducing thermal buildup.Conclusions:These findings suggest that the helical milling tool and technique optimize robot-assisted osteotomy and effectively mitigate frictional heat generation at the drill–bone interface.This innovation holds promise for enhancing osseointegration success rates in dental implant procedures,offering a clinically viable solution to a long-standing challenge in implantology. 展开更多
关键词 Drill-milling technology Robot-assisted drilling Implant osteotomy preparation Finite-element analysis Temperature control
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Erratum to"Crosslinked Colorless Polyimide Films via Oxazole Groups as Crosslinking Agent:Preparation and Properties" 认领 引用
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作者 He Wang Zhen-Chao Liu +3 位作者 Xue Shang Li-Dong Feng Xin-Chao Bian Xue-Si Chen 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第5期1574-1574,共1页
We are sorry for the mistakes of the author information"He Wang a,b,Zhen-Chao Liub,Xue Shangb,Li-Dong Fengb*,Xin-Chao Bianb and Xue-Si Chen b*"should be replaced by"He Wang a,b,Zhen-Chao Liub,Xue Shangb... We are sorry for the mistakes of the author information"He Wang a,b,Zhen-Chao Liub,Xue Shangb,Li-Dong Fengb*,Xin-Chao Bianb and Xue-Si Chen b*"should be replaced by"He Wang a,b,Zhen-Chao Liub,Xue Shangb,Li-Dong Fengb*,Xin-Chao Bianb and Xue-Si Chen a,b*".We apologized for the inconvenience caused by this error. 展开更多
关键词 crosslinked polyimide films oxazole groups properties preparation
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Advances in preparation and modification strategies of CeO2 nanozymes and potential clinical applications 认领 引用
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作者 Zhixuan Li Xinying Wang +1 位作者 Han Wu Qingxiang Guan 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期170-181,共12页
Cerium oxide nanozymes(CeO2 NZs)exhibit enzyme mimetic activities and great promise for biomedical applications by mediating the dynamic cycling between Ce3+and Ce4+.However,traditional preparation methods ar... Cerium oxide nanozymes(CeO2 NZs)exhibit enzyme mimetic activities and great promise for biomedical applications by mediating the dynamic cycling between Ce3+and Ce4+.However,traditional preparation methods are often expensive and detrimental to the environment.Meanwhile,the problems of easy agglomeration,poor targeting and weak biocompatibility need to be solved.The available literatures have mainly reviewed CeO2 NZs in terms of its material properties,mechanisms and potential clinical applications.The literatures on the limitations of CeO2 NZs and the corresponding improvement methods are fragmented.Consequently,the limitations of CeO2 NZs and the strategies involving green preparation technology and modification mainly summarized,while the biosafety of the modification strategies are compared.Meanwhile,representative studies of potential clinical applications of CeO2 NZs over the past three years are outlined,along with a summary of their clinical translational prospects and challenges.Finally,the challenges of CeO2 NZs promotion technology are discussed. 展开更多
关键词 Cerium oxide Nanozymes Green preparation methods Modification strategies Clinical applications
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A machine learning strategy for rapid design of preparation parameters in zero-sample complex alloy 认领 引用
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作者 Hui-qiang MA Hong-tao ZHANG +2 位作者 Hua-dong FU Jing-tai SUN Jian-xin XIE 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第3期855-871,共17页
To address the zero-sample challenge in preparation parameter design for newly developed alloys,a novel machine learning strategy that integrates basic dataset construction with Bayesian optimization,was proposed.The ... To address the zero-sample challenge in preparation parameter design for newly developed alloys,a novel machine learning strategy that integrates basic dataset construction with Bayesian optimization,was proposed.The impact of basic sample dataset construction methods,optimization benchmarks and multi-objective utility functions on Bayesian optimization was investigated.It was found that the combination of orthogonal design,linear benchmark,and shifted multiplicative utility function exhibits the best optimization performance.The strategy was then applied to a new Cu-Ni-Co-Si alloy with ultra-low Co content(0.7 wt.%Co),previously designed by our research team.Rapid optimization of six preparation parameters in the two-stage deformation and aging process of the zero-sample alloy was achieved through only 23 experiments.The measured ultimate tensile strength and electrical conductivity of the new alloy were 878 MPa and 44.0%(IACS),respectively,reaching the comprehensive performance level of the Cu-Ni-Co-Si alloy(C70350 alloy)containing 1.0-2.0 wt.%Co. 展开更多
关键词 Cu-Ni-Co-Si alloy preparation parameters machine learning Bayesian optimization
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Advantages of low dose polyethylene glycol+ascorbate split-dose colonoscopy preparation for colorectal screening 认领 引用
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作者 Caterina Palmonari Nicolo Landini +6 位作者 Chiara Zanforlin Michela Borghesi Viviana Cifalà Claudio Gregorio Alessandro Pezzoli Admena Rreshketa Chiara Chiericati 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第7期334-345,共12页
BACKGROUND Colorectal cancer is the third occurring neoplasm type worldwide,with approximately two million people cases in 2020.Hence,activation of accurate screening and diagnostic protocols within the population is ... BACKGROUND Colorectal cancer is the third occurring neoplasm type worldwide,with approximately two million people cases in 2020.Hence,activation of accurate screening and diagnostic protocols within the population is crucial for its prevention,contributing to public health improvement along with healthcare costs containment.Colonoscopy represents the gold standard for lesion detection,yet remains an invasive and distressful procedure,also due requiring appropriate intestinal prep through ingestion of laxative concoctions.For the Italian National Health System,this preparation is administered as 4-liter of polyethylene glycol(PEG),split in two rounds,which often results in insufficient bowel cleanliness to perform colonoscopy.AIM To implement a less distressful and more efficient preparation for colonoscopy preparation,to improve bowel cleansing.METHODS After obtaining the permission from the local National Health System management in 2022,1-liter of PEG(1L-PEG)and ascorbate(ASC)was administered to patients as colonoscopy preparation,instead of the usual 4-liter of PEG.RESULTS The 1L-PEG+ASC gave improved results at the end of 2023,with 96.33%of acceptable cleansing among the screened population,of which 63.56%resulting in Optimal cleaning level for the Boston Scale.The colonoscopy adherence from patients increased in the period observed from 78.30% to 85.20%.CONCLUSION Implementing 1L-PEG+ASC gave better results than other preparations and diminished patient distress,leading to an increase in the operative colonoscopies percentage,and positively influencing the adherence to the screening protocol. 展开更多
关键词 Colorectal cancer Colonoscopy preparation Polyethylene glycol Diagnostics Colonoscopy Preventive medicine Oncological screening Oncology Drugs implementation Medical protocols
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Low-volume bowel preparation provides safe and effective panenteric capsule endoscopy in suspected or established Crohn’s disease 认领 引用
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作者 Snir Livne Nathaniel Aviv Cohen +4 位作者 Naomi Fliss-Isakov Moshe Leshno Nitsan Maharshak Eva Niv Liat Deutsch 《World Journal of Gastrointestinal Endoscopy》 2026年第1期139-150,共12页
BACKGROUND Effective pan-enteric capsule endoscopy(PCE)visualization requires thorough bowel preparation.We hypothesized that a novel low-volume protocol(LVP)provides comparable safety and effectiveness to the standar... BACKGROUND Effective pan-enteric capsule endoscopy(PCE)visualization requires thorough bowel preparation.We hypothesized that a novel low-volume protocol(LVP)provides comparable safety and effectiveness to the standard high-volume protocol(HVP).AIM To evaluate the safety and effectiveness of a novel low-volume vs standard highvolume preparation protocol for PCE.METHODS We conducted an observational study including all prospectively documented PCEs at our tertiary center(2018-2021),comparing preparation adequacy and completion rates between patients receiving LVP vs HVP.Preparation adequacy was evaluated by two blinded expert readers(Cohen’s kappa,correlation tests).Finally,an individual participant data meta-analysis combining our cohort with three published cohorts assessed PCE outcomes with HVP vs LVP.A P value<0.05 was considered statistically significant in all tests.RESULTS Our analysis included 67 patients:12(17.9%)underwent PCE with HVP,and 55(82.1%)with LVP.No post-PCE complications were reported.PCE completion was achieved by 89.1%of the LVP group and 75.0%of the HVP group.Adequate small bowel and colonic preparation rates were comparable between the HVP and LVP groups(90.9%vs 89.1%,and 80.0%vs 90.0%,respectively).In our individual patient data meta-analysis,the combined HVP(n=257)and the LVP(n=55)were comparable regarding completion rates(87.2%vs 89.1%)and adequate small bowel preparation rates(90.0%vs 89.1%);however,LVP had higher rates of adequate colonic preparation vs combined HVP(80.0%vs 62.7%,respectively,P=0.017).CONCLUSION LVP is a safe and effective alternative to HVP with similar completion rates,better colonic preparation,and lower volume,making it preferable for patients with suspected or diagnosed Crohn’s disease. 展开更多
关键词 Pan-enteric capsule endoscopy Bowel preparation Crohn’s disease Low-volume protocol Completion rate
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Advancing bowel preparation:DWJ1609 represents a patientcentered evolution in colonoscopy preparation 认领 引用
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作者 Iyad A Issa Taly Issa 《World Journal of Gastroenterology》 SCIE CAS 2026年第30期25-31,共7页
Bowel preparation quality remains a central determinant of colonoscopy success,yet patient intolerance to existing regimens continues to limit adherence to colorectal cancer screening.In a recent phase III randomized ... Bowel preparation quality remains a central determinant of colonoscopy success,yet patient intolerance to existing regimens continues to limit adherence to colorectal cancer screening.In a recent phase III randomized controlled trial,DWJ1609,a novel oral sulfate tablet(OST)formulation,was designed to improve the patient experience without compromising cleansing efficacy.By reducing sulfate content by approximately 75%and incorporating sodium picosulfate to maintain laxative effectiveness,DWJ1609 achieved a 96.97%successful cleansing rate,meeting noninferiority criteria compared with conventional OSTs.More importantly,the formulation demonstrated a markedly improved tolerability profile,with nearly half the rate of adverse drug reactions and substantial reductions in nausea and headache—symptoms that frequently deter patients from undergoing colonoscopy.These findings highlight a meaningful shift toward patient-centered bowel preparation,addressing a longstanding barrier to screening participation.While the study population was younger and healthier than typical screening cohorts,and further validation in high-risk groups is needed,the results suggest that DWJ1609 may offer a more acceptable and safer alternative for many patients.As colorectal cancer screening expands to younger populations,innovations that enhance preparation tolerability will play an increasingly important role in improving screening uptake and outcomes. 展开更多
关键词 Bowel preparation Colonoscopy Oral sulfate tablets DWJ1609 Colorectal cancer screening Sodium picosulfate Bowel cleansing efficacy
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Bowel preparation for small bowel capsule endoscopy in patients with suspected or established Crohn’s disease 认领 引用
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作者 Shohei Terashi Sotaro Ozaka +11 位作者 Yomei Kagoshima Yuta Shimomori Haruhiko Takahashi Daisuke Minezaki Koshiro Tsutsumi Masahide Fukuda Yuka Hirashita Kensuke Fukuda Ryo Ogawa Masaaki Kodama Kazunari Murakami Kazuhiro Mizukami 《World Journal of Gastrointestinal Endoscopy》 2026年第2期85-93,共9页
BACKGROUND Although small-bowel capsule endoscopy(SBCE)is an important tool in the diagnosis of Crohn's disease(CD),the necessity and consensus protocol of preprocedural bowel pre-treatment for SBCE in patients wi... BACKGROUND Although small-bowel capsule endoscopy(SBCE)is an important tool in the diagnosis of Crohn's disease(CD),the necessity and consensus protocol of preprocedural bowel pre-treatment for SBCE in patients with CD have not yet been established.AIM To evaluate the diagnostic performance and mucosal visibility of SBCE with and without bowel preparation in patients with CD.METHODS Patients with suspected or established CD who underwent SBCE at our hospital between January 2015 and March 2025 were included in this retrospective observational study.SBCE was performed after bowel preparation with fasting only or with 1 L of polyethylene glycol solution with liquid simethicone.The primary outcome was the lesion detection rate.Secondary outcomes were the completion rate of the examination,image quality,gastric transit time,small bowel transit time,and adverse events related to SBCE.RESULTS Fifty-seven patients were included in the study.The detection rates of lesions were 95.6%in the non-preparation group and 96.6%in the preparation group,with no significant differences between the two groups.The two groups showed no significant differences in completion rates,gastric transit time,small bowel transit time,or visibility score.One patient in the preparation group experienced intestinal obstruction.CONCLUSION The diagnostic performance and mucosal visibility of SBCE for CD were not significantly improved by pre-procedural bowel preparation. 展开更多
关键词 Bowel preparation Capsule endoscopy Crohn's disease Small intestine Visibility
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Optimization of the Extraction Process and Establishment of the Preparation Method for Guichen Xuanfei Mixture 认领 引用
19
作者 Lifu WEI Shengbin CHEN +4 位作者 Xiren ZHENG Xiumei MA Bing QING Zhenying FU Wen ZHONG 《Medicinal Plant》 2026年第3期11-14,共4页
[Objectives]To optimize the extraction and preparation processes of Guichen Xuanfei Mixture and establish a foundation for its industrial-scale production.[Methods]Using the dry paste rate as the evaluation index,a si... [Objectives]To optimize the extraction and preparation processes of Guichen Xuanfei Mixture and establish a foundation for its industrial-scale production.[Methods]Using the dry paste rate as the evaluation index,a single-factor experiment was conducted to examine the effects of soaking time,volume of water added,and extraction duration.Subsequently,orthogonal experiments were employed to optimize the volume of water added,extraction duration,and extraction frequency.Following the determination of the optimal extraction process,process validation tests and pilot-scale production were performed.[Results]The optimal extraction process involved soaking the medicinal materials in water for 30 min,followed by two successive boiling steps.During the first extraction,8 times the volume of water relative to the material was used,and 6 times the volume was applied during the second extraction.Each extraction was conducted for 1 h.The average dry paste rate obtained from the verification test was 24.25%,while the yield rates for the three batches of pilot-scale production were 93.6%,93.9%,and 93.6%,respectively.[Conclusions]The optimized extraction and preparation method is rational,stable,and demonstrates excellent reproducibility,making it well-suited for the industrial-scale production of Guichen Xuanfei Mixture. 展开更多
关键词 Guichen Xuanfei Mixture Extraction process Preparation method
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Direct preparation of LiOH fromα-spodumene with improved autoclave dissolution in NaOH−Na2SO4−CaO system 认领 引用
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作者 Shu-hao DONG Ya-kai YANG +4 位作者 Dong-qi SONG Hao ZHANG Hui GUO Jiu-qing LIU Min GAN 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第8期2469-2482,共14页
An alkaline autoclave dissolution method was developed to directly extract LiOH fromα-spodumene in NaOH−Na2SO4−CaO system.Approximately 90.3%Li,10.27%Si,and 9.62%Al were leached under optimal conditions:ore to ... An alkaline autoclave dissolution method was developed to directly extract LiOH fromα-spodumene in NaOH−Na2SO4−CaO system.Approximately 90.3%Li,10.27%Si,and 9.62%Al were leached under optimal conditions:ore to CaO mass ratio of 1:1,liquid-to-solid ratio of 14 mL/g,NaOH and Na2SO4mass concentrations both of 15%at 280℃for 3 h.Notably,the addition of Na2SO4was found to selectively replace Li+while simultaneously reduce NaOH consumption.Kinetic analysis was also provided further insight into the dissolution behavior ofα-spodumene in this system.This innovative autoclave process can eliminate the energy-intensive high-temperature calcination for phase transformation,and enables the direct preparation of LiOH·H2O fromα-spodumene. 展开更多
关键词 spodumene lithium extraction autoclave dissolution alkaline system LiOH preparation
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