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Automatic Generation of UML Class Diagrams for Object-oriented Design and Programing Course 认领 引用
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作者 Chunyan Ma Jing Chen +1 位作者 Zheng Chang Jiangbin Zheng 《计算机教育》 2021年第12期157-165,共9页
UML Class diagram generation from textual requirements is an important task in object-oriented design and programing course.This study proposes a method for automatically generating class diagrams from Chinese textual... UML Class diagram generation from textual requirements is an important task in object-oriented design and programing course.This study proposes a method for automatically generating class diagrams from Chinese textual requirements on the basis of Natural Language Processing(NLP)and mapping rules for sentence pattern matching.First,classes are identified through entity recognition rules and candidate class pruning rules using NLP from requirements.Second,class attributes and relationships between classes are extracted using mapping rules for sentence pattern matching on the basis of NLP.Third,we developed an assistant tool integrated into a precision micro classroom system for automatic generation of class diagram,to effectively assist the teaching of object-oriented design and programing course.Results are evaluated with precision,accuracy and recall from eight requirements of object-oriented design and programing course using truth values created by teachers.Our research should benefit beginners of object-oriented design and programing course,who may be students or software developers.It helps them to create correct domain models represented in the UML class diagram. 展开更多
关键词 UML class diagram Natural Language Processing(NLP) object-oriented design and programming course automatic generation
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PROPORTION OF THE CEMENT RAW MATERIAL CALCULATED BY THE LINEAR PROGRAMING 认领 引用
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作者 冯仲仁 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 1997年第4期29-34,共6页
This paper presents a new method .linear programming method. to calculate the proportion of the cement raw material. Its advanlages are as following : good practicability, convenience for analysis, and being easy for ... This paper presents a new method .linear programming method. to calculate the proportion of the cement raw material. Its advanlages are as following : good practicability, convenience for analysis, and being easy for controlling. The mathematical model given in the paper is apt to be realized on computer. 展开更多
关键词 proportion of cement raiv material ear programming
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Prenatal programing of motivated behaviors:can innate immunity prime behavior? 认领 引用 被引量：1
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作者 Larisa Montalvo-Martínez Gabriela Cruz-Carrillo +3 位作者 Roger Maldonado-Ruiz Luis ATrujillo-Villarreal Eduardo AGarza-Villarreal Alberto Camacho-Morales 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第2期280-283,共4页
Prenatal programming during pregnancy sets physiological outcomes in the offspring by integrating external or internal stimuli.Accordingly,pregnancy is an important stage of physiological adaptations to the environmen... Prenatal programming during pregnancy sets physiological outcomes in the offspring by integrating external or internal stimuli.Accordingly,pregnancy is an important stage of physiological adaptations to the environment where the fetus becomes exposed and adapted to the maternal milieu.Maternal exposure to high-energy dense diets can affect motivated behavior in the offs p ring leading to addiction and impaired sociability.A high-energy dense exposure also increases the pro-inflammatory cytokines profile in plasma and brain and favors microglia activation in the offspring.While still under investigation,prenatal exposure to high-energy dense diets promotes structural abnormalities in selective brain regions regulating motivation and social behavior in the offspring.The current review addresses the role of energy-dense foods programming central and peripheral inflammatory profiles during embryonic development and its effect on motivated behavior in the offspring.We provide preclinical and clinical evidence that supports the contribution of prenatal programming in shaping immune profiles that favor structural and brain circuit disruption leading to aberrant motivated behaviors after birth.We hope this minireview encourages future research on novel insights into the mechanisms underlying maternal programming of motivated behavior by central immune networks. 展开更多
关键词 addiction autism behavior cytokines diet maternal immune activation prenatal programming sociability trained immunity western-diets
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Stemness CD24 activation promotes hepatocellular carcinoma progression via an immune escape mechanism 认领 引用 被引量：2
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作者 Yin Cai Lu-Yin Liu +5 位作者 Xiao-Xiao Xia Hao Tang Min Xu Wen-Li Sai Deng-Fu Yao Min Yao 《World Journal of Gastroenterology》 SCIE CAS 2026年第3期143-156,共14页
BACKGROUND Cluster of differentiation 24(CD24)serves as a liver cancer stem cell marker,and its upregulation is related to chronic liver disease malignancy.However,the exact relationship between CD24 expression and he... BACKGROUND Cluster of differentiation 24(CD24)serves as a liver cancer stem cell marker,and its upregulation is related to chronic liver disease malignancy.However,the exact relationship between CD24 expression and hepatocarcinogenesis remains unknown.AIM To investigate CD24 levels among individuals with chronic liver diseases and confirm the alterations in CD24 and programmed death-ligand 1(PD-L1)expression in a dynamic model of rat hepatocarcinogenesis.METHODS Approved by the ethics committee,CD24 levels were detected in the serum of 129 patients with hepatocellular carcinoma(HCC),72 patients with chronic hepatitis(CH),60 patients with liver cirrhosis(LC)and 111 normal control(NC).Receiver operating characteristic curves and clinicopathological characteristics of CD24 were used to evaluate the diagnostic or prognostic value for HCC,and the CD24+T lymphocyte ratio and dynamic alterations in CD24 and PD-L1 expression were confirmed in a rat HCC model.RESULTS Compared with those in the CH,LC and NC groups,the average CD24 level in the HCC group was significantly greater(P<0.01).The CD24+T-cell ratio in the HCC group was greater than that in the CH or NC group.Clinicopathological characteristics of high CD24 in HCC patients included hepatitis B virus infection,single/multicenter status,tumor size,lymph node or extrahepatic metastasis,differentiation degree,tumor-node-metastasis grade,Child-Pugh score,portal vein tumor thrombus and poor prognosis.Mechanistically,CD24 is dynamically upregulated during hepatocarcinogenesis and closely positively correlated with PD-L1 for immune escape,metastasis(CD44),and with respect to HCC markers(Wnt3a,GPC-3 and alpha-fetoprotein).CONCLUSION Activated CD24 promoted HCC formation through programmed death-ligand 1 signaling and could be a valuable biomarker for monitoring chronic liver disease malignancy. 展开更多
关键词 Clusters of differentiation 24 Hepatocarcinogenesis Programmed death-ligand 1 Biomarker Chronic liver disease
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Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration 认领 引用 被引量：2
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作者 Xiaoxu Huang Yumeng Zhang +9 位作者 Yuxin Jiang Tong Li Shiqi Yang Yimin Wang Bo Yu Minwen Zhou Guanran Zhang Xiaohuan Zhao Junran Sun Xiaodong Sun 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期406-416,共11页
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal deg... Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss.Ferroptosis has been demonstrated to be associated with retinal degenerative diseases.However,the molecular mechanisms underlying ferroptosis and photoreceptor cell death in age-related macular degeneration remain largely unexplored.Bioinformatics and biochemical analyses in this study revealed xC–,solute carrier family 7 member 11-regulated ferroptosis as the predominant pathological process of photoreceptor cell degeneration in a light-induced dry age-related macular degeneration mouse model.This process involves the nuclear factor-erythroid factor 2-related factor 2-solute carrier family 7 member 11-glutathione peroxidase 4 signaling pathway,through which cystine depletion,iron ion accumulation,and enhanced lipid peroxidation ultimately lead to photoreceptor cell death and subsequent visual function impairment.We demonstrated that solute carrier family 7 member 11 overexpression blocked this process by inhibiting oxidative stress in vitro and in vivo.Conversely,solute carrier family 7 member 11 knockdown or the solute carrier family 7 member 11 inhibitor sulfasalazine and ferroptosis-inducing agent erastin aggravated H2O2-induced ferroptosis of 661W cells.These findings indicate solute carrier family 7 member 11 may be a potential therapeutic target for patients with retinal degenerative diseases including age-related macular degeneration. 展开更多
关键词 age-related macular degeneration ferroptosis light exposure damage oxidative stress pathway photoreceptor programmed cell death solute carrier family 7 member 11(SLC7A11)
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Quality-guaranteed Dubins Path Planning for USV Based on Mixed-integer Piecewise linear Programming for Addressing the Extended Minimum-time Intercept Problem 认领 引用 被引量：1
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作者 Xing Zhou Kelin Zhu +3 位作者 Shuang Liu Zhaoqing Li Wenxin Zhang Kang Du 《哈尔滨工程大学学报（英文版）》 CSCD 2026年第1期216-227,共12页
During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive... During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h2/(4√2),where h is the piecewise length. 展开更多
关键词 Minimum-time intercept problem Dubins vehicle Mixed-integer piecewise-linear program Linearization Approximate error trigonometric function USV
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High PD-L1 expression as a negative prognostic factor in stageⅢbut not in stageⅡgastric cancer 认领 引用 被引量：1
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作者 Hui-Min Zhang Feng-Ping Li +10 位作者 Heng-Yi Zhang Xin-Ru Liu Xin-Hua Chen Hua-Yuan Liang Xiao Yan Qing Xie Rou Zhong Min Lai Xue-Feng Zhong Hao Liu Li-Ying Zhao 《World Journal of Gastroenterology》 SCIE CAS 2026年第8期44-58,共15页
BACKGROUND The prognostic value of programmed death ligand-1(PD-L1)expression in patients with gastric or gastroesophageal junction cancer(G/GEJC)at different stages remains unclear.We hypothesized that high PD-L1 exp... BACKGROUND The prognostic value of programmed death ligand-1(PD-L1)expression in patients with gastric or gastroesophageal junction cancer(G/GEJC)at different stages remains unclear.We hypothesized that high PD-L1 expression is associated with poor survival in patients with pathological stageⅢ(pⅢ)G/GEJC.AIM To investigate the relation between PD-L1 expression and survival outcomes in patients with pathological stageⅡ(pⅡ)-pⅢG/GEJC.METHODS In this retrospective cohort study,we collected the clinicopathological data of 388 consecutive patients with pⅡ/pⅢG/GEJC who underwent gastrectomy without neoadjuvant therapy at Nanfang Hospital,Southern Medical University.Postoperative tissue samples were collected to evaluate PD-L1 expression.Combined positive score(CPS)≥1 was defined as PD-L1-positive,and CPS≥5 as high PD-L1 expression.Survival outcomes were analyzed using Kaplan-Meier and Cox proportional hazards models.RESULTS In pⅡG/GEJC,no significant differences were found in 3-year disease-free survival(DFS;88.5%vs 87.9%,P=0.939)or 3-year overall survival(OS;92.3%vs 89.9%,P=0.621)between PD-L1-positive and PD-L1-negative groups or between high and low PD-L1 expression groups(3-year DFS:91.8%vs 84.2%,P=0.138;3-year OS:94.2%vs 88.4%,P=0.233).In pⅢG/GEJC,PD-L1-positive patients had poorer 3-year DFS(52.2%vs 67.8%,P=0.030)and 3-year OS(65.1%vs 78.2%,P=0.007)than PD-L1-negative patients.High PD-L1 expression was associated with significantly inferior 3-year DFS(50.2%vs 64.8%,P=0.023)and 3-year OS(64.0%vs 75.1%,P=0.036)compared to low PD-L1 expression.Multivariate analysis revealed that high PD-L1 expression was independently associated with shorter DFS(HR=1.624,P=0.027)and OS(HR=1.653,P=0.043)in patients with pⅢG/GEJC.Sensitivity analyses confirmed the robustness of the OS findings.CONCLUSION High PD-L1 expression serves as an independent adverse prognostic biomarker in stageⅢbut not stageⅡG/GEJC.These findings indicate a stage-dependent prognostic value of PD-L1 expression in G/GEJC. 展开更多
关键词 Survival Prognosis Locally advanced gastric cancer Combined positive score Programmed death ligand-1
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An overview of mathematical programming solvers:Theory,development,and recent advances 认领 引用
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作者 Lei HUANG Fan XIAO +2 位作者 Dongdong GE Wotao YIN Zhe LIANG 《ENGINEERING Management》 CSCD 2026年第1期1-16,共16页
Mathematical programming solvers are software tools designed to solve real‑world problems using mathematical programming algorithms.This survey explores the evolution of optimization technologies,from traditional meth... Mathematical programming solvers are software tools designed to solve real‑world problems using mathematical programming algorithms.This survey explores the evolution of optimization technologies,from traditional methods such as the simplex algorithm and branch‑and‑bound techniques to modern advancements that are facilitated by parallel computing,GPU acceleration,and AI algorithms.We also emphasize the recent emergence of mathematical programming solvers developed by research institutes and companies headquartered in China as major players,who have achieved remarkable success in benchmarks when compared to established solvers.This article provides a comprehensive overview of the theoretical foundations,historical progress,and emerging trends in mathematical programming solvers,offering valuable insights for both researchers and practitioners in the field. 展开更多
关键词 survey mathematical programming solver linear programming mixed‑integer programming nonlinear programming
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Pharmacological mechanisms of natural products with antidepressant effects:A focus on the programmed cell death regulation 认领 引用
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作者 Guangheng Zhang Shimeng Lv +9 位作者 Shengchuan Bao Weijie Zhao Yunhao Yi Haonan Gao Xia Zhong Xiangyu Li Fengzhao Liu Yitong Lu Siyuan Sun Jing Teng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期120-141,共22页
Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increase... Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increased,making it the second-largest global health burden.The pathogenesis of depression involves a series of complex pathological mechanisms,although the key underlying causes remain unclear.Programmed cell death(PCD),including apoptosis,autophagy,pyroptosis,ferroptosis,and necroptosis,involves highly organized gene expression processes that may influence the occurrence and development of depression by regulating cellular fate.Furthermore,numerous studies have shown that natural products can modulate PCDs through various signaling pathways,presenting significant potential for managing depression.Natural products offer benefits such as cost-effectiveness,fewer side effects,and other advantages,making them viable supplements or alternatives to traditional antidepressant drugs.To explore this potential,we reviewed studies demonstrating the antidepressant effects of natural products through multi-target modulation of PCDs.In addition,we discussed the toxicity and clinical applications of these natural products.This study highlights that diverse core biological pathways and targets are involved in determining the fate of depression-associated brain cells,including the PI3K/Akt signaling pathway,caspase-8,GSDMD,and others.In conclusion,the multi-target mechanisms of PCD regulation by natural products may provide a promising foundation for the future development of novel antidepressant medications. 展开更多
关键词 Depression Pharmacological mechanism Programmed cell death Natural products Antidepressant
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Multi-phase trajectory programming with divert capability for lunar lander powered descent 认领 引用
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作者 ZHANG Xiaowen WANG Dayi +2 位作者 HUANG Xiangyu LI Ji WANG Tianshu 《中国空间科学技术（中英文）》 CSCD 北大核心 2026年第3期143-156,共14页
It is important for a lunar lander to possess a large divert capability during the final landing phase,as this can enhance the tolerance for flight deviations in the early phase or improve the obstacle avoidance perfo... It is important for a lunar lander to possess a large divert capability during the final landing phase,as this can enhance the tolerance for flight deviations in the early phase or improve the obstacle avoidance performance.Therefore,when designing the powered descent trajectory,sufficient final phase divert capability should be reserved at the minimum propellant cost.To this end,a multi-phase trajectory programming(MPTP)method for powered descent with approaching phase divert capability is proposed.First,the entire powered descent trajectory is divided into the main braking phase and the approaching phase.The main braking phase is responsible for dissipating the majority of the initial velocity.The approaching phase is responsible for safely and precisely flying toward the landing site.It is nominally a vertical descent trajectory and possesses equal divert capability in all horizontal directions.Then,a constant-thrust linear tangent guidance(LTG)accounting for the lunar curvature is designed for the main braking phase.For the approaching phase,a variable-thrust lossless convex programming(LCP)guidance considering the constraints of tilt angle and glide-slope angle is developed.Subsequently,to connect the two phases and further optimize the propellant consumption throughout the entire trajectory,a method for determining the phase switching condition is proposed.The originally difficult-to-solve two-parameter optimization problem is decomposed into two more easily solvable subproblems,which are solved iteratively via a bilevel optimization framework.Finally,the divert capability of the proposed method is verified through numerical simulation.The programmed trajectory is basically consistent with the results of the pseudospectral method,with the difference in propellant consumption being only 0.006%.This method is suitable for the rapid iterative design of nominal trajectories for lunar lander powered descent in engineering applications. 展开更多
关键词 lunar landing powered descent trajectory programming multi-phase divert capability
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FTCSEM—A FORTRAN-based parallelized 1D CSEM forward and inversion program for arbitrary source-receiver geometry 认领 引用
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作者 Wei-ying Chen Si-xu Han +2 位作者 Wan-ting Song Yu-lian Zhu Zheng Liu 《Applied Geophysics》 SCIE CSCD 2026年第2期693-709,870,共17页
This study introduces FTCSEM,a FORTRAN-based,parallelized one-dimensional controlledsource electromagnetic(CSEM)forward modeling and inversion software capable of accommodating arbitrary source-receiver confi guration... This study introduces FTCSEM,a FORTRAN-based,parallelized one-dimensional controlledsource electromagnetic(CSEM)forward modeling and inversion software capable of accommodating arbitrary source-receiver confi gurations.In comparison to existing one-dimensional CSEM tools,FTCSEM incorporates several signifi cant enhancements:it supports transmitters of diverse shapes,quantities,and spatial locations;permits receivers to be positioned flexibly on the surface,subsurface,or in the atmosphere;facilitates simulations and inversions in both frequency and time domains;integrates an adaptive regularized inversion algorithm with multiple model constraints;and leverages GPU-accelerated parallel computing to attain high computational efficiency.Validation through numerical experiments and field data inversion confirms the program’s accuracy and practical applicability.The findings indicate that FTCSEM performs robustly in complex geoelectric environments,multi-source and multi-receiver arrangements,as well as multi-component joint inversion scenarios,thereby offering a versatile and powerful tool for advancing CSEM research and applications. 展开更多
关键词 CSEM forward modeling regularized inversion parallel computing program
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High-frequency irreversible electroporation synergizes with PD-1/PDL1 inhibitor BMS-1 and TLR7/8 agonist R848 to potentiate liver cancer antitumor immunity 认领 引用
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作者 Shi-Ming Huang Xiao-Bo Zhang +10 位作者 Jing Li Guo-Hui Zhang Xiao Zhang Ying-Tian Wei Hui Sun Li Ma Zhen-Jun Wang Di-Xiao Yao Hong-Jian Shi Ti Wang Yue-Yong Xiao 《World Journal of Gastroenterology》 SCIE CAS 2026年第15期102-123,共22页
BACKGROUND High-frequency irreversible electroporation(H-FIRE),a second-generation tumor ablation therapy,has demonstrated efficacy and safety in treating liver cancer.However,its clinical application is hindered by t... BACKGROUND High-frequency irreversible electroporation(H-FIRE),a second-generation tumor ablation therapy,has demonstrated efficacy and safety in treating liver cancer.However,its clinical application is hindered by the risk of residual disease and metastasis resulting from incomplete ablation,while H-FIRE’s inherent capacity to induce immunogenic cell death(ICD)provides a potential direction for optimizing its efficacy.AIM To leverage H-FIRE’s ICD capacity,and investigate the efficacy and safety of H-FIRE combined with immunotherapy in the treatment of liver cancer.METHODS A murine subcutaneous hepatocellular carcinoma model was established using hepatoma 22 cells.Mice were randomized into eight groups:Control,BMS-1,R848,BMS-1+R848,H-FIRE,H-FIRE+BMS-1,H-FIRE+R848,and H-FIRE+BMS-1+R848.Treatments comprised:Intraperitoneal BMS-1 and intratumoral R848 administered every 2 days(4 total doses);H-FIRE ablation performed once when tumors reached 7-8 mm in long diameter.Efficacy was assessed by monitoring survival,primary tumor volume,primary tumor cell proliferation and damageassociated molecular patterns expression,immune microenvironment alterations in primary tumors and spleens,distant secondary tumor apoptosis,and treatment safety.RESULTS H-FIRE robustly induced ICD in primary liver tumors.Notably,the triple-combination therapy(H-FIRE+BMS-1+R848)exerted the most potent antitumor efficacy:It significantly reduced primary tumor burden relative to all other monotherapy or dual-combination groups,with a mean tumor volume of 305.3±35.0 mm3 in the triplecombination group.This therapeutic benefit was further confirmed by markedly extended overall survival,with median survival times of 17,24.5,25,28.5,28.5,33.5,37.5,and 53 days,respectively.Mechanistically,the triplecombination strategy was accompanied by enhanced tumor cell apoptosis and suppressed cell proliferation,underscoring its multi-faceted antitumor effects.In primary tumors and spleens,this combination markedly increased proportions of CD3+CD4+T cells,CD3+CD8+T cells,CD11c+CD80+CD86+dendritic cells,F4/80+CD11b+CD86+M1 macrophages,and the M1/M2 macrophage ratio.Conversely,it reduced proportions of CD4+CD25+FOXP3+regulatory T cells and F4/80+CD11b+CD206+M2 macrophages,with no significant toxicity observed.Furthermore,the triple therapy effectively promoted apoptosis and inhibited growth in distant secondary tumors.CONCLUSION The triple therapy synergistically reverses local and systemic immune tolerance,eliciting robust anti-tumor immunity.This strategy not only effectively inhibits primary and secondary tumor progression but also exhibits favorable safety,underscoring its potential as a novel combinatorial cancer treatment. 展开更多
关键词 Liver cancer High-frequency irreversible electroporation Programmed death-1/programmed death-ligand 1 inhibitor Toll-like receptor 7/8 agonist Antitumor immunity
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OPFEM:architectural design and implementation of a CAE software for finite element modeling and simulation 认领 引用
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作者 Wei Huang Qun Huang +3 位作者 Jie Yang Xiaowei Bai Tianyun He Heng Hu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第2期264-333,共70页
To address challenges in architectural extensibility and cross-module collaboration of CAE software,this study proposes OPFEM(open-source Python-based finite element modeling)—an open-source framework featuring a uni... To address challenges in architectural extensibility and cross-module collaboration of CAE software,this study proposes OPFEM(open-source Python-based finite element modeling)—an open-source framework featuring a unified four-layer architecture.The geometric modeling framework achieves plug-in support for geometric kernels through an interface abstraction layer and adapter patterns,decoupling kernel-specific implementations while enabling state machine-driven interaction design and parametric sketching.The pre-processing modules establish multi-level associations among materials,sections,and geometric entities using Composite and Factory patterns,while implementing Observer pattern to ensure geometric-mesh consistency and employing finite-state machines to optimize boundary workflows.The computational modules implement a modular finite element library that decouples topology from element attributes,along with a surface boundary element technique for load conversion and task-scheduling management,validated through a cantilever beam large-deformation case.The post-processing module facilitates standardized data storage and dynamic field visualization through architecture-level standardized interface definitions and hierarchical component design.Collectively,OPFEM achieves full-process integration from parametric modeling to nonlinear solving and visualization,enhancing configuration efficiency and providing an extensible,pattern-driven solution for complex CAE challenges. 展开更多
关键词 Finite element method CAE software architecture Object-oriented programming Modular design Opensource software
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Open-loop control of combustion instabilities in a full-scale annular ramjet combustor using linear genetic programming 认领 引用
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作者 Jianguo TAN Zheng XU +2 位作者 Yao LIU Dongdong ZHANG Yi HOU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第2期20-28,共9页
The operational demands of a wide range significantly exacerbate combustion instability issues within ramjet combustor.To suppress combustion oscillations,an open-loop control system utilizing Linear Genetic Programmi... The operational demands of a wide range significantly exacerbate combustion instability issues within ramjet combustor.To suppress combustion oscillations,an open-loop control system utilizing Linear Genetic Programming(LGP)has been developed for a full-scale annular ramjet combustor.The LGP is used to generate control laws that include multi-frequency forcing.These laws are then transformed into square waves to actuate the solenoid valve,which modulates the kerosene supply for open-loop control.The results show that the duty cycle has little effect on instability amplitude,whereas an increase in frequency leads to a remarked reduction in combustion amplitude.After five generations evolvements,the pressure amplitude is reduced by 40.6% under the optimal control law generated by LGP.Furthermore,the machine learning process is depicted using a proximity map of control law similarity,with the search pathway visualized by the steepest descent.All individuals go forward to the upper left corner of the map with the evolution process,terminating at the optimal individual of the fifth generation. 展开更多
关键词 Annular ramjet combustor Combustion instabilities Linear genetic programming Machine learning Open-loop control
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Reprogramming induced neurons from olfactory ensheathing glial cells: A feasible approach for spinal cord injury repair 认领 引用
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作者 Javier Sierra María Portela-Lomba +1 位作者 Diana Simón M.Teresa Moreno-Flores 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期296-297,共2页
Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disruptin... Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons. 展开更多
关键词 injury feasible programming
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CD44-targeting and ZIF-8 gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death 认领 引用
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作者 Xin Li Fei Xiong +7 位作者 Xudong Cao Wei Liu Haobo Chen Jiayu He Weina Zhang Longguang Tang Wei Huang Xikuang Yao 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期462-467,共6页
The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD... The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD inducer is severely hindered by complex biological barriers.How to design and build intelligent nanoplatform for adaptive and dynamic cancer therapy remains a big challenge.Herein,this article presents the design and preparation of CD44-targeting and ZIF-8 gated gold nanocage(Au@ZH) for programmed delivery of the 1,2-diaminocyclohexane-Pt(Ⅱ)(DACHPt) as ICD inducer.After actively targeting the CD44 on the surface of 4T1 tumor cell,this Pt-Au@ZH can be effectively endocytosed by the 4T1 cell and release the DACHPt in tumor acidic environment,resulting in ICD effect and superior antitumor efficacy both in vitro and in vivo in the presence of mild 808 nm laser irradiation.By integration of internal and external stimuli intelligently,this programmed nanoplatform is poised to become a cornerstone in the pursuit of effective and targeted cancer therapy in the foreseeable future. 展开更多
关键词 Programmed drug release ZIF-8-gated Gold nanocage Immunogenic cell death Cancer therapy
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Entry trajectory optimization for cross-domain morphing vehicles by hybrid sequential second-order cone programming 认领 引用
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作者 Zheng Li Zhenyue Jia +2 位作者 Zheng Fang Hongmiao Zhou Jianqiao Yu 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第4期149-175,共27页
This paper proposes a hybrid sequential second-order cone programming(HSSOCP)method with a three-layer scheme for the entry trajectory optimization of the cross-domain morphing vehicles(CDMVs).By defining the new morp... This paper proposes a hybrid sequential second-order cone programming(HSSOCP)method with a three-layer scheme for the entry trajectory optimization of the cross-domain morphing vehicles(CDMVs).By defining the new morphing rate control variable and using relaxation techniques to relax the bank angle constraint,the SOCP-based entry problem is constructed.A dynamic relaxation penal-ization technique is developed in the first layer to overcome artificial infeasibility and significantly enhance initialization robustness.A novel standard oscillation identification(SOI)method is proposed to precisely identify the iteration oscillations of basic SSOCP in the second layer,which can significantly improve the solution accuracy.A soft-trust-region strategy is applied in the third layer to eliminate oscillations and accelerate convergence.Simulation results of two scenarios demonstrate that the proposed SOI method effectively avoids non-standard oscillation interference versus traditional methods.The morphing aircraft can complete tasks better with a 7.01%and 10.43%reduction in heat load respectively compared to fixed-wing aircraft.The HSSOCP method can maintain accuracy while reducing computation time by 63.47%and 73.86%versus VATSSOCP.Monte Carlo simulations further validate the robustness. 展开更多
关键词 Cross-domain vehicle Morphing vehicle Entry trajectory optimization Sequential second-order cone programming Iteration oscillation Hybrid scheme
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Root cortical senescence:An adaptive mechanism for drought tolerance in crops 认领 引用
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作者 Congcong Guo Xiaoyuan Bao +10 位作者 Ke Zhang Lingxiao Zhu Jiaqi Zhang Xuejing Liu Hong Fan Lianhao Zhao Wen Yin Liantao Liu Cai Zhao Qiang Chai Cundong Li 《The Crop Journal》 SCIE CSCD 2026年第4期1110-1122,共13页
Senescence allows plants to remove unnecessary tissues and recycle nutrients.Substantial work has focused on the senescence of aboveground tissues such as leaves;by contrast,the senescence of underground tissues has i... Senescence allows plants to remove unnecessary tissues and recycle nutrients.Substantial work has focused on the senescence of aboveground tissues such as leaves;by contrast,the senescence of underground tissues has important functions in response to stresses such as drought.The root cortex transports water and provides structure to the root.Root cortical senescence(RCS)involves the programmed cell death of root cortical cells and allows the plant to adjust root system architecture and decrease the metabolic burden of maintaining root tissue.In this review,we synthesize current knowledge on RCS and its responses to drought stress.This review also examines the regulation of RCS at multiple levels and the differences in RCS between monocots and dicots.We further identify major challenges in characterizing RCS,understanding its mechanisms,and applying it in breeding,with an emphasis on bridging laboratory findings and field performance through genotype-by-environment analyses.Finally,we explore potential research directions and breeding targets for translating RCS into improved drought tolerance and yield stability in crops.This helps to clarify the physiological mechanisms of RCS,root system and leaf senescence,enhances the understanding of root system functions,and has significant theoretical value and practical significance for the prevention and control of crop premature senescence as well as the selection of anti-senescence varieties. 展开更多
关键词 Root cortical senescence Programmed cell death Drought tolerance Root system functions Premature senescence
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Barriers and facilitators of the implementation of a leadership training program based on the Developing and Sustaining Nursing Leadership Best Practice Guideline:A qualitative study 认领 引用
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作者 Mi Zhao Zhenhui Tao +3 位作者 Jialei Feng Li Song Yangliu Li Dong Pang 《International Journal of Nursing Sciences》 CSCD 2026年第3期273-281,共9页
Objectives This study aimed to identify barriers and facilitators influencing the implementation of a leadership training program based on the Developing and Sustaining Nursing Leadership Best Practice Guideline for n... Objectives This study aimed to identify barriers and facilitators influencing the implementation of a leadership training program based on the Developing and Sustaining Nursing Leadership Best Practice Guideline for nurse managers.Methods The descriptive qualitative study was conducted through semi-structured individual interviews at a tertiary hospital in Beijing,China.We selected 16 nurse managers who had participated in a leadership training program using a purposive sampling method with a maximum variation strategy from March to August 2024.The collected data were analyzed using thematic analysis.Results This study identified 7 barriers and 17 facilitators guided by the Consolidated Framework for Implementation Research(CFIR).Barriers were identified as:intervention characteristics(complexity of content,excessive content,challenging assignments after training,gap between theory and practice,and time-consuming),and inner setting(unclear training goals,mentor incompetence).Key facilitators emerged from:intervention characteristics(internally developed content,Best Practice Guideline with high level of evidence,focusing on leadership competency for manager,logically connected design),outer setting(meeting participants’needs,networking with leadership authority,peer pressure),inner setting(effective communication,supported teamwork,tension for change,fitting the participants’value),characteristics of individuals(intrinsic motivation,self-efficacy,beginning or mid-stage of change),and process(planning developed in advance,full motivation,feedback and team debriefing)domains.Conclusions This study identified drivers of implementation for a leadership training program in the Chinese context.These findings support the successful delivery of this program and can inform future leadership training and support improvements in nurse managers’leadership. 展开更多
关键词 Barriers Consolidated framework for implementation research Facilitators Nursing leadership Qualitative study Training program
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Trends in Two-Week Prevalence of Fever and Diarrhea Among Infants and Young Children in Rural—China,2016-2025 认领 引用
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作者 Yanli Wei Lijuan Wang +2 位作者 Jian Huang Jing Sun Junsheng Huo 《China CDC weekly》 SCIE CSCD 2026年第28期873-878,共6页
Introduction:Infants and young children(IYC)aged 6-23 months are vulnerable to fever and diarrhea;however,the long-term trend data in poor rural China remain scarce.Methods:Data were derived from ten rounds of cross-s... Introduction:Infants and young children(IYC)aged 6-23 months are vulnerable to fever and diarrhea;however,the long-term trend data in poor rural China remain scarce.Methods:Data were derived from ten rounds of cross-sectional surveys(2016-2025)under the Nutrition Improvement Program for Children in Poor Areas(NIPCPA),using a multi-stage cluster sampling design.Information on fever and diarrhea in the preceding two weeks was collected through caregiverreported questionnaires.The Cochran-Armitage trend test was used to assess overall and subgroup-specific temporal trends.Results:A total of 422,425 IYC aged 6-23 months were included.The two-week prevalence of fever declined overall from 13.1%(4,236/32,444)to 7.0%(3,139/44,592),with a nadir of 5.6%(2,408/43,008)in 2021;diarrhea decreased overall from 12.3%(3,991/32,444)to 4.2%(1,886/44,592),with a nadir of 3.9%(1,580/40,707)in 2022;and concurrent fever and diarrhea decreased from 4.1%(1,321/32,444)to 1.4%(640/44,592)(all P<0.01).Significant downward trends were observed across all subgroups.Younger children(6-11 months)consistently showed higher prevalence but greater reductions over time.Males had higher baseline prevalence than females but experienced larger declines.Children with normal birth weight exhibited more pronounced improvements than those with low birth weight.Higher maternal education levels and maternal caregiving were associated with lower prevalence.Conclusion:The two-week prevalence of fever and diarrhea among IYC in poor rural China has decreased substantially,which may reflect the combined effects of economic development,strengthened public health systems,and large-scale nutrition interventions. 展开更多
关键词 Cochran Armitage trend test nutrition improvement program rural China prevalence fever trends diarrhea infants young children
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