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Misdiagnosis of psoriatic arthritis in a patient with paronychia confirmed by dermatological examination:A case report 认领 引用
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作者 Angelo Nigro 《World Journal of Clinical Cases》 2025年第18期60-64,共5页
BACKGROUND This case highlights the importance of a multidisciplinary approach in differentiating localized infections from systemic inflammatory diseases like psoriatic arthritis.Nail psoriasis can mimic conditions l... BACKGROUND This case highlights the importance of a multidisciplinary approach in differentiating localized infections from systemic inflammatory diseases like psoriatic arthritis.Nail psoriasis can mimic conditions like paronychia,complicating diagnosis.We wrote this report to emphasize the need for clinical vigilance when interpreting imaging findings,especially in patients with a family history of psoriasis.Misdiagnosis can lead to unnecessary systemic treatments,underscoring the significance of dermatological input in achieving accurate diagnoses.CASE SUMMARY A 56-year-old woman presented with redness and swelling of multiple fingertips.Her family history of psoriasis raised suspicion of psoriatic arthritis.Two rheumatologists diagnosed psoriatic arthritis based on ultrasound findings of enthesitis with a positive Doppler signal and recommended methotrexate.However,she was reluctant to initiate therapy due to potential side effects.At our Rheumatology Center,paronychia was suspected,and laboratory tests excluded systemic inflammatory arthritis.Dermatological examination confirmed paronychia,and treatment with fluconazole and ceftriaxone was initiated to address suspected mixed bacterial and fungal infections.Imaging studies,including hand and wrist X-rays,showed no erosions or other signs of psoriatic arthritis.The patient responded well to antimicrobial therapy,with resolution of symptoms.This case highlights the need for thorough clinical evaluation,careful interpretation of imaging findings,and collaboration between rheumatologists and dermatologists to avoid misdiagnosis and inappropriate treatment.CONCLUSION This case underscores the need for thorough clinical evaluation and caution in interpreting nonspecific imaging findings,especially in patients with a family history of psoriasis.While familial predisposition may raise suspicion for psoriatic arthritis,it is essential to integrate laboratory data,imaging studies,and clinical presentation,including response to targeted antimicrobial therapy.A multidisciplinary approach,involving both rheumatologists and dermatologists,is crucial to preventing misdiagnosis,ensuring appropriate treatment,and avoiding the potential harms of unwarranted therapies. 展开更多
关键词 Psoriatic arthritis Paronychia Misdiagnosis Multidisciplinary approach Case report
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Does ultrasound detect joint and intestinal changes in psoriatic arthritis and ulcerative colitis after immunobiological treatment:A case report 认领 引用
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作者 Jose Alexandre Mendonca Jose Luis Braga de Aquino 《World Journal of Radiology》 2025年第8期84-90,共7页
BACKGROUND Ultrasound(US)can be a valuable tool for assessing arthritis associated with inflammatory bowel disease(IBD),especially in cases of psoriatic disease.The clinical case reviewed in this article addresses an ... BACKGROUND Ultrasound(US)can be a valuable tool for assessing arthritis associated with inflammatory bowel disease(IBD),especially in cases of psoriatic disease.The clinical case reviewed in this article addresses an exploratory finding that evaluates the effects of immunobiological treatments on dactylitis and IBD with the use of US techniques.CASE SUMMARY A 40-year-old Caucasian woman with psoriatic arthritis(PsA)and ulcerative colitis(UC)reported experiencing finger pain,knee arthritis,and bloody diarrhea.She showed a high Disease Activity index for PsA score and a severe Mayo score.She began treatment with adalimumab.Over the course of six months,the 18 MHz US procedure was performed on her joints and a 3.5 MHz US on her intestines.The joint US indicated dactylitis and swelling in her finger joints,while the intestinal US revealed 6.6 mm swelling in the sigmoid colon,increased abdominal fat,and high Doppler signal.Her fecal calprotectin level was 5984 mg/kg,and a colonoscopy showed that UC extended to the hepatic flexure,along with mild narrowing of the transverse colon.After six months treatment,all parameters showed improvement,including a remission of the Mayo score,better colonoscopy results,and Limberg score of 0.CONCLUSION More research is needed to find out the importance of using US in patients with PsA and UC as this could improve treatment strategies. 展开更多
关键词 Ultrasonography Psoriatic arthritis Ulcerative colitis Tumor necrosis factor Case report
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Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis:A Systematic Review 认领 引用 被引量：4
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作者 Changbing Shen Jing Gao +4 位作者 Xianyong Yin Yujun Sheng Liangdan Sun Yong Cui Xuejun Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2015年第2期49-56,共8页
Psoriasis （Ps） and psoriatic arthritis （PsA） are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop （LC... Psoriasis （Ps） and psoriatic arthritis （PsA） are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop （LCE） gene cluster, especially the cluster 3 （LCE3） genes. It is noteworthy that the deletion of LCE3B and LCE3C （LCE3C_LCE3B-del） is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future. 展开更多
关键词 LCE3 genes Psoriasis Psoriatic arthritis Systematic review
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Infliximab treatment in two Chinese patients with psoriatic arthritis 认领 引用 被引量：4
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作者 Xi XIE Jin-wei CHEN +3 位作者 Fen LI Jing TIAN Jie-sheng GAO David ZHANG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS 2010年第10期779-782,共4页
Psoriatic arthritis(PsA) is a rheumatoid factor(RF)-seronegative systemic inflammatory disorder associated with psoriasis.Current treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs(D... Psoriatic arthritis(PsA) is a rheumatoid factor(RF)-seronegative systemic inflammatory disorder associated with psoriasis.Current treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs(DMARDs).In this paper,we report two Chinese patients with active longstanding PsA treated with infliximab,a human-mouse chimeric monoclonal antibody against tumor necrosis factor alpha(TNF-α).The results show that infliximab acted quickly and effectively in relieving peripheral and axial symptoms and refractory skin lesions,even in recombinant human TNF-α receptor(rhTNFR)-resistant case.The take-home message from our cases is that infliximab is a useful therapeutic option for refractory PsA,especially when a patient has a combination of psoriasis and psoriatic arthritis.Further local evidence and experience must be accumulated in order to make anti-TNF-α therapy more accessible to PsA patients in China. 展开更多
关键词 Refractory psoriatic arthritis Skin lesions Infliximab Anti-tumor necrosis factor alpha （TNF-α） treatment
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Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies 认领 引用 被引量：3
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作者 Chao-Ran Li Lang Chen +3 位作者 Long-Fei Wang Bin Yan You-Ling Liang Jing Luo 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第4期650-659,共10页
AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed... AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed a comprehensive search of Pub Med and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis(Ps A)]. We used a random-effects model to calculate the pooled relative risks(RRs) adjusted for confounders, along with the 95% confidence intervals(CIs). RESULTS: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis(RR=1.49;95%CI: 1.08-2.07), and Ps A(RR=3.16;95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis(RR=1.62;95%CI: 1.44-1.83), and Ps A(RR=4.44;95%CI: 3.52-5.60).CONCLUSION: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease(psoriasis and Ps A), warranting increased awareness among clinicians involved in the management of these two conditions.Therefore, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis. 展开更多
关键词 Meta-analysis psoriasis psoriatic arthritis risk uveitis
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Psoriatic arthritis: Epidemiology, diagnosis, and treatment 认领 引用 被引量：5
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作者 Jung-Tai Liu Horng-Ming Yeh +1 位作者 Shyun-Yeu Liu Kow-Tong Chen 《World Journal of Orthopedics》 2014年第4期537-543,共7页
Our understanding of psoriatic arthritis has evolved as new knowledge of the disease has emerged. However, the exact prevalence of psoriatic arthritis is unknown, and its pathogenesis has not been fully elucidated. Ge... Our understanding of psoriatic arthritis has evolved as new knowledge of the disease has emerged. However, the exact prevalence of psoriatic arthritis is unknown, and its pathogenesis has not been fully elucidated. Genetic, environmental, and immunologic factors have all been implicated in disease development. Early diagnosis and treatment have become primary objectives in clinical rheumatology. Psoriatic arthritis not only causes functional impairment, but also increases mortality risk of patients. The advent of new therapeutic agents capable of arresting the progression of joint damage is expected. However, early psoriatic arthritis assessment remains limited. The objectives of this article are to outline the epidemiology, diagnosis, and treatment of psoriatic arthritis and to suggest a paradigm for identifying early psoriatic arthritis patients. 展开更多
关键词 Arthritis Psoriasis Psoriatic arthritis Spondyloarthritis
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Umbilical cord blood stem cell treatment for a patient with psoriatic arthritis 认领 引用 被引量：4
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作者 Margaret Coutts Rowena Soriano +1 位作者 Rajendran Naidoo Habib Torfi 《World Journal of Stem Cells》 SCIE 2017年第12期235-240,共6页
Clinical and laboratory results document psoriatic arthritis in a 56-year old patient. The symptoms did not resolve with standard treatments(nonsteroidal anti-inflammatory drugs, steroids and methotrexate). TNF-alpha ... Clinical and laboratory results document psoriatic arthritis in a 56-year old patient. The symptoms did not resolve with standard treatments(nonsteroidal anti-inflammatory drugs, steroids and methotrexate). TNF-alpha inhibitors(certolizumab pegol and adalimumab) were added to the treatment regime, with some adverse effects. A trial of human umbilical cord stem cell therapy was then initiated. The stem cells were enriched and concentrated from whole cord blood, by removal of erythrocytes and centrifugation. The patient received several infusions of cord blood stem cells, through intravenous and intra-articular injections. These stem cell treatments correlated with remission of symptoms(joint pain and psoriatic plaques) and normalized serologic results for the inflammatory markers C-reactive protein and erythrocyte sedimentation rate. These improvements were noted within the first thirty days post-treatment, and were sustained for more than one year. The results of this trial suggest that cord blood stem cells may have important therapeutic value for patients with psoriatic arthritis, particularly for those who cannot tolerate standard treatments. 展开更多
关键词 Umbilical cord blood stem cells Stem cells Psoriatic arthritis Rheumatoid arthritis
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Pembrolizumab-induced psoriatic arthritis treated with disease-modifying anti-rheumatic drugs in a patient with gastric cancer:A case report 认领 引用 被引量：2
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作者 Sehan Kim Jong Hee Sun +5 位作者 Hongsik Kim Hee Kyung Kim Yaewon Yang Jun Su Lee In Ah Choi Hye Sook Han 《World Journal of Clinical Cases》 SCIE 2023年第1期218-224,共7页
BACKGROUND Immune checkpoint inhibitor(ICI)-induced rheumatic immune-related adverse events(ir AEs)have been infrequently reported,and the treatment of severe or refractory arthritis as ir AEs has not been established... BACKGROUND Immune checkpoint inhibitor(ICI)-induced rheumatic immune-related adverse events(ir AEs)have been infrequently reported,and the treatment of severe or refractory arthritis as ir AEs has not been established yet.CASE SUMMARY The patient was a 67-year-old man with a history of well-controlled foot psoriasis who presented with polyarthralgia.He had received pembrolizumab for metastatic gastric adenocarcinoma 2 mo previously.Physical examination revealed erythematous swelling in the distal interphalangeal joints,left shoulder,and both knees.He had plaque psoriasis with psoriatic nail dystrophy and dactylitis in the distal joints of the fingers and toes.Inflammatory markers including C-reactive protein and erythrocyte sedimentation rate were elevated but rheumatoid factor and anticyclic citrullinated peptide antibody were negative.The patient was diagnosed with psoriatic arthritis(PsA)and started on methylprednisolone 1 mg/kg/day after pembrolizumab discontinuation.However,despite 1 wk of methylprednisolone treatment,PsA worsened;hence,leflunomide and methotrexate were started.After 4 wk of steroid treatment,PsA worsened and improved repeatedly with steroid tapering.Therefore,the therapy was intensified to include etanercept,a tumor necrosis factor inhibitor,which ultimately resulted in adequate PsA control.CONCLUSION This is the first report of ICI-induced PsA in a gastric cancer patient.Some rheumatic ir AEs with refractory severe arthritis may require disease-modifying anti-rheumatic drugs and long-term management. 展开更多
关键词 Pembrolizumab Psoriatic arthritis Disease-modifying anti-rheumatic drugs Gastric cancer Case report
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Anti-and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis,psoriatic arthritis and ankylosing spondylitis 认领 引用 被引量：5
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作者 Chrong-Reen Wang Hung-Wen Tsai 《World Journal of Diabetes》 SCIE 2021年第3期238-260,共23页
In addition toβ-cell failure with inadequate insulin secretion,the crucial mechanism leading to establishment of diabetes mellitus(DM)is the resistance of target cells to insulin,i.e.insulin resistance(IR),indicating... In addition toβ-cell failure with inadequate insulin secretion,the crucial mechanism leading to establishment of diabetes mellitus(DM)is the resistance of target cells to insulin,i.e.insulin resistance(IR),indicating a requirement of beyond-normal insulin concentrations to maintain euglycemic status and an ineffective strength of transduction signaling from the receptor,downstream to the substrates of insulin action.IR is a common feature of most metabolic disorders,particularly type II DM as well as some cases of type I DM.A variety of human inammatory disorders with increased levels of proinflammatory cytokines,including tumor necrosis factor(TNF)-α,interleukin(IL)-6 and IL-1β,have been reported to be associated with an increased risk of IR.Autoimmunemediated arthritis conditions,including rheumatoid arthritis(RA),psoriatic arthritis(PsA)and ankylosing spondylitis(AS),with the involvement of proinflammatory cytokines as their central pathogenesis,have been demonstrated to be associated with IR,especially during the active disease state.There is an increasing trend towards using biologic agents and small molecule-targeted drugs to treat such disorders.In this review,we focus on the effects of anti-TNF-α-and non-TNF-α-targeted therapies on IR in patients with RA,PsA and AS.Anti-TNF-αtherapy,IL-1 blockade,IL-6 antagonist,Janus kinase inhibitor and phosphodiesterase type 4 blocker can reduce IR and improve diabetic hyper-glycemia in autoimmune-mediated arthritis. 展开更多
关键词 Insulin resistance Diabetes mellitus Tumor necrosis factor-α-targeted therapy Non-tumor necrosis factor-α-targeted therapy Rheumatoid arthritis Psoriatic arthritis
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Diagnosis and treatment of psoriatic arthritis with concealed rash: a case report 认领 引用
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作者 Teng Huang Shaopeng Du +2 位作者 Xiaojing Liu Zhenhua Liu Bin Hao 《TMR Clinical Research》 2019年第2期57-63,共7页
Psoriatic arthritis is a kind of arthritis associated with psoriasis. The clinical manifestations of psoriatic arthritis with arthritis as the first symptom are often similar to ankylosing spondylitis and rheumatoid a... Psoriatic arthritis is a kind of arthritis associated with psoriasis. The clinical manifestations of psoriatic arthritis with arthritis as the first symptom are often similar to ankylosing spondylitis and rheumatoid arthritis. Thus differential diagnosis should be made in clinical practice so as to improve the therapeutic effect. Psoriatic arthritis skin lesions are usually papules or plaques, with scales on the surface and punctate hemorrhage on the basement. About 10% of patients with psoriatic arthritis have skin rash after the onset of arthritis. In order to provide a reference for clinicians, our study the analyzed the clinical diagnosis of psoriatic arthritis in combination with a case of psoriatic arthritis with concealed skin rash and related literatures. 展开更多
关键词 psoriatic arthritis concealed rash clinical diagnosis
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Targeting the Inflammation Culprit in Patients with Psoriasis/Psoriatic Arthritis and Associated Cardiovascular Comorbidities. Is the IL-17 Inhibitor the New Kid on the Block? 认领 引用
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作者 Cornel Pater 《World Journal of Cardiovascular Diseases》 CAS 2019年第4期267-294,共28页
Despite half-century old, but comprehensive national and international guidance, evidence of clinical effectiveness and widespread agreement on management of risk factors along with sophisticated measures for primary ... Despite half-century old, but comprehensive national and international guidance, evidence of clinical effectiveness and widespread agreement on management of risk factors along with sophisticated measures for primary and secondary prevention of major cardiovascular events, cardiovascular disease remains the dominant cause of death and disability world-wide. Life style changes at population-level (e.g., lower salt and saturated fat consumption or reduced/banned amount of industrially-produced trans fatty acids in specific products, etc.) or changes at individual level (e.g., targeting modifiable risk factors/life style changes affecting smokingobacco use, poor diet, high blood cholesterol, high blood pressure, insufficient physical activity, overweight/obesity) have reduced coronary heart disease mortality to variable extent in different countries (mostly so reported in Finland, Iceland and Sweden) at the beginning of the new century. Overall, however, cardiovascular mortality is estimated to increase in the next coming years until 2030 at a cost exceeding US $1044 billion. Several decades of status quo are also noted in the therapeutic spectrum of cardiovascular disease, mainly consisting of variations to LDL-C lowering agents, antihypertensives, anticoagulants, antiplatelets and fibrinolytics. Most of the therapeutic interventions are “tertiary” in nature (probably some 60%), meaning that treatment is instituted once the individual has developed a pathologic condition;“secondary prevention” may cover some 25%?-?30% (meant to prevent re-occurrence of the condition or occurrence of complications) while “primary prevention” is left with 10%?-?15% share (most commonly implying life style changes at individual level and rarely pharmacological intervention). For almost three decades, the so-called inflammatory hypothesis has been promoted as a reasonable pathogenetic theory behind initiation and growth of atherosclerotic plaque (Alexander RW, 1994;Ross R, 1999). With the discovery of molecular and cellular pathways that promote atherosclerosis and the role of cytokines as inflammatory messengers, the concept as such—inflammation, has received a primordial role?in atherogenesis. The present review paper aims at ascertaining the role of inflammation as a common pathogenetic denominator of cardiovascular disease in patients primarily treated for their psoriasis and/or psoriatic arthritis. 展开更多
关键词 Psoriasis Psoriatic Arthritis Cardiovascular Comorbidities Inflammation Cy-tokines IL-17
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Effects of a Nurse-Led Educational Intervention for Chinese Adult Patients with Psoriatic Arthritis: A Case-Control Study 认领 引用
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作者 Bishan Cai Tiantian Xin +2 位作者 Aizhen Yan Luna Wu Li Wang 《Open Journal of Nursing》 2016年第2期110-114,共5页
The aim of this study was to evaluate the effect of an individual nurse-led educational intervention for patients with psoriatic arthritis (PsA). This was a case-control study. The case group consisted of six individu... The aim of this study was to evaluate the effect of an individual nurse-led educational intervention for patients with psoriatic arthritis (PsA). This was a case-control study. The case group consisted of six individual educational sessions delivered by a nurse. A total of 40 patients with PsA joined in this study: the case group (n = 20) and the control group (n = 18). After a 6-week intervention, the case group had significantly better management for the severity of arthritis symptoms (p < 0.05), better psychological well-being and significant lower levels of anxiety (p < 0.05), and depression score (p < 0.01), and reported better improvement of physical and psychological domain of quality of life (QOL) (both p values < 0.05) than the control group. In conclusion, this nurse-led individual education intervention has statistically significant benefits for the management of clinical symptoms of arthritis and for psychological well-being and QOL in patients with PsA. 展开更多
关键词 Nurse-Led Interventions Psoriatic Arthristis Chinese Patients Case-Control Study
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A Needs-Based Rheumatologist Education Program on Treating to Target in Psoriatic Arthritis and Spondyloarthropathy: Insights and Challenges 认领 引用
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作者 Janet Pope Linda Wang +9 位作者 Paul Tingey Angela Montgomery Art Karasik Pauline Boulos Vandana Ahluwalia Maggie Larche Sara Haig Nikhil Chopra Gina Rohekar Sherry Rohekar 《Open Journal of Rheumatology and Autoimmune Diseases》 2017年第1期53-64,共12页
Objectives: To determine if comparative practice data and education for rheumatologists would change physician behavior for monitoring and treating psoriatic arthritis (PsA) and spondyloarthritis (SpA). Methods: Parti... Objectives: To determine if comparative practice data and education for rheumatologists would change physician behavior for monitoring and treating psoriatic arthritis (PsA) and spondyloarthritis (SpA). Methods: Participating rheumatologists each performed a chart audit on 20 patients with PsA and SpA. Accredited education (determined by a survey and chart audits) and results of chart audits (comparing to other rheumatologists) were provided for each participant (intervention). Eight months later, a repeat chart audit by each participant was conducted on another 20 PsA and SpA patients. Changes in measurements collected, treatment given and patient characteristics pre and post intervention were analyzed. Results: Nine rheumatologists received the intervention. At baseline, most routinely monitored PsA and SpA for clinical and laboratory markers. In PsA, there was no change post-intervention in performing SJC (96%), TJC (≥91%), ESR (≥70%), CRP (≥73%), and CDAI (25%). In SpA, there were increased measurements of inflammatory markers (54% pre vs. 61% post for CRP), more NSAID use and decreased physical exam measures and HAQ but no significant changes. There were no major treatment differences pre and post intervention including NSAIDs, DMARDs and biologics. Conclusions: The rheumatologists frequently performed measurements of disease activity, did not change significantly with educational intervention so there may have been little room for improvement and many patients were already in a low disease state. Calculation of composite scores did not increase in PsA. The validity of physical exam and BASDAI as a measurement of disease activity were noted as concerns in applying a treat-to-target approach in SpA. Significance and Innovation: This study did not show a significant change in behavior for rheumatologists who had education based on care gaps and needs assessment in psoriatic arthritis and spondyloarthropathy. The rheumatologists identified that disease activity is difficult to determine with usual care in SpA and thought some measures lacked validity. 展开更多
关键词 Education Seronegative Arthritis Psoriatic Arthritis Ankylosing Spondylitis Behavioral Change Outcome Assessments
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Genetic Factors and Psoriatic Arthritis 认领 引用
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作者 Monica Greco Simone Negrini +4 位作者 Chiara Schiavi Francesca Giusti Matteo Borro Francesco Puppo Giuseppe Murdaca 《Open Journal of Rheumatology and Autoimmune Diseases》 2019年第3期111-120,共10页
Psoriatic arthritis (PsA) is a complex immune-mediated disease and its pathogenesis depends both on genetic factors and environment. PsA patients may present a wide range of clinical manifestations including skin and ... Psoriatic arthritis (PsA) is a complex immune-mediated disease and its pathogenesis depends both on genetic factors and environment. PsA patients may present a wide range of clinical manifestations including skin and nail abnormalities. Indeed, articular involvement is variable too. Disease development relies on a heterogeneous net made of multiple cytokines pathways which are regulated by several factors including human leucocyte antigen (HLA) expression, miRNAs, microbiome. Among genetic polymorphisms which can lead to abnormal cytokine expression, tumor necrosis factor (TNF) polymorphisms have been studied. Thus, leading to the development of new therapeutic agents. Finally, further studies on genetic factors and epigenetics will give new insights into this complex disorder. The aim of this mini-review is to provide the reader with a summary of the fundamental and most innovative aspects of genetic and epigenetic factors involved in the PsA, thus including human leucocyte antigen (HLA) expression, tumor necrosis factor (TNF) polymorphisms, micro RNAs and microbiome. 展开更多
关键词 Psoriatic Arthritis Psoriasis HLA Associations Genetic Heterogeneity Phenotypic Heterogeneity Epigenetics Micro RNA Microbiome TNF Polymorphisms
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Role of leptin in the progression of psoriatic,rheumatoid and osteoarthritis 认领 引用
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作者 Jessica Mounessa Iryna Voloshyna +1 位作者 Amy D Glass Allison B Reiss 《World Journal of Rheumatology》 2016年第1期9-15,共7页
Leptin,an adipokine responsible for body weight regulation,may be involved in pathological processesrelated to inflammation in joint disorders including rheumatoid arthritis(RA),osteoarthritis,and psoriatic arthritis(... Leptin,an adipokine responsible for body weight regulation,may be involved in pathological processesrelated to inflammation in joint disorders including rheumatoid arthritis(RA),osteoarthritis,and psoriatic arthritis(PsA).These arthropathies have been associated with a wide range of systemic and inflammatory con-ditions including cardiovascular disease,obesity,and metabolic syndrome.As a potent mediator of immune responses,leptin has been found in some studies to play a role in these disorders.Furthermore,current potent biologic treatments effectively used in Ps A including ustekinumab(an interleukin 12/23 blocker) and ada-limumab(a tumor necrosis factor-alpha blocker also used in RA) have been found to increase leptin receptor expression in human macrophages.This literature review aims to further investigate the role leptin may play in the disease activity of these arthropathies. 展开更多
关键词 Psoriatic arthritis Rheumatoid arthritis Leptin Ustekinumab Tumor necrosis factor-alpha
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What have we learned about non-involved psoriatic skin from large-scale expression studies? 认领 引用
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作者 Eszter Szlavicz Kornelia Szabo +2 位作者 Zsuzsanna Bata-Csorgo Lajos Kemeny Marta Szell 《World Journal of Dermatology》 2014年第3期50-57,共8页
Psoriasis is a chronic inflammatory skin disorder; its genetic background has been widely studied in recent decades. Recognition of novel factors contributing to the pathogenesis of this disorder was facilitated by po... Psoriasis is a chronic inflammatory skin disorder; its genetic background has been widely studied in recent decades. Recognition of novel factors contributing to the pathogenesis of this disorder was facilitated by potent molecular biology tools developed during the 1990 s. Large-scale gene expression studies, including differential display and microarray, have been used in experimental dermatology to a great extent; moreover, skin was one of the first organs analyzed using these methods. We performed our first comprehensive gene expression analysis in 2000. With the help of differential display and microarray, we have discovered several novel factors contributing to the inherited susceptibility for psoriasis, including the EDA+ fibronectin splice variant and PRINS. The long non-coding PRINS RNA is expressed at higher levels in non-involved skin compared to healthy and involved psoriatic epidermis and might be a factor contributing cellular stress responses and, specifically, to the development of psoriatic symptoms. This review summarizes the most important results of our large-scale gene expression studies. 展开更多
关键词 Non-involved psoriatic skin Differential display cDNA microarray EDA+fibronectin isoform PRINS long non-coding RNA mRNA maturation
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Psoriatic arthritis: clinical patterns, rheumatoid factor, anti-cyclic citrullinated peptide and human leukocyte antigen risk alleles 认领 引用
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作者 Devolina Bhowmik Shirin Tarafder Manash Chandra Sarker 《TMR Aging》 2020年第3期89-96,共8页
Psoriatic arthritis is an inflammatory arthritis associated with psoriasis.Both rheumatoid factor and anti-cyclic citrullinated peptide antibodies positive psoriatic arthritis patients may be in risk for development o... Psoriatic arthritis is an inflammatory arthritis associated with psoriasis.Both rheumatoid factor and anti-cyclic citrullinated peptide antibodies positive psoriatic arthritis patients may be in risk for development of symmetrical polyarthritis pattern.Symmetrical polyarthritis pattern was predominant(42%)among clinical pattern of psoriatic arthritis.Among 10 rheumatoid factor positive patients,8(80%)patients had symmetrical polyarthritis pattern and out of 7 anti-cyclic citrullinated peptide antibody positive patients,7(100%)patients had symmetrical polyarthritis pattern.Association of anti-cyclic citrullinated peptide(P=0.008)and rheumatoid factor(P=0.006)showed statistical significance with symmetrical polyarthritis pattern.Human leukocyte antigen-B*07,*38 and human leukocyte antigen-C*07 were predominantly found in rheumatoid factor and anti-cyclic citrullinated peptide positive psoriatic arthritis patients.Background:Psoriatic arthritis is an inflammatory arthritis associated with psoriasis.It is usually seronegative in nature but a small percentage of patients may be positive for rheumatoid factor and anti-cyclic citrullinated peptide antibodies.Anti-cyclic citrullinated peptide and rheumatoid factor are highly specific for rheumatoid arthritis but their role is not clear in psoriatic arthritis.The prevalence and prognostic value of anti-cyclic citrullinated peptide antibody and rheumatoid factor in psoriatic arthritis patients is not well known.The aim of this study was therefore to investigate the prevalence of anti-cyclic citrullinated peptide antibodies and rheumatoid factor in psoriatic arthritis patients and assess their clinical associations and also to see the distribution of human leukocyte antigen-B and human leukocyte antigen-C locus antigens in anti-cyclic citrullinated peptide antibody and rheumatoid factor positive psoriatic arthritis patients.Methods:Fifty patients with psoriatic arthritis were tested for the presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies.Polymerase chain reaction was done with sequence specific primer for detection of human leukocyte antigen-B and human leukocyte antigen-C locus antigens in rheumatoid factor and anti-cyclic citrullinated peptide positive psoriatic arthritis patients.Data on five clinical patterns of rheumatological manifestations of psoriatic arthritis patients were collected prospectively on all patients and statistically compared between anti-cyclic citrullinated peptide,rheumatoid factor positive and negative patients by chi-square test.We also see the distribution of human leukocyte antigen-B and human leukocyte antigen-C locus antigens in anti-cyclic citrullinated peptide antibody and rheumatoid factor positive psoriatic arthritis patients.Results:Among 50 psoriatic arthritis patients,rheumatoid arthritis test was positive in 10(20%)patients and anti-cyclic citrullinated peptide was positive in 7(14%)patients.Symmetrical polyarthritis pattern is predominant among clinical pattern of psoriatic arthritis which was found in 21(42%)patients.Among 7 anti-cyclic citrullinated peptide positive psoriatic arthritis patients,symmetrical polyarthritis pattern is predominant and it was found in 7(100%)patients.Among 10 rheumatoid factor positive psoriatic arthritis patients,symmetrical polyarthritis pattern is predominant and it was found in 8(80%)patients.In this study,symmetrical polyarthritis pattern is statistically associated with anti-cyclic citrullinated peptide positive psoriatic arthritis patients(P=0.008)and rheumatoid factor positive psoriatic arthritis patients(P=0.006).Human leukocyte antigen-B*07,*38 and human leukocyte antigen-C*07 were predominantly found in rheumatoid factor and anti-cyclic citrullinated peptide positive psoriatic arthritis patients.Conclusion:Both rheumatoid factor and anti-cyclic citrullinated peptide positive psoriatic arthritis patients may be in risk for development of symmetrical polyarthritis pattern.Among rheumatoid factor and anti-cyclic citrullinated peptide positive psoriatic arthritis patients,Human leukocyte antigen-B*07,*38 and human leukocyte antigen-C*07 alleles were more frequently found alleles. 展开更多
关键词 Psoriatic arthritis Rhematoid factor Anti-cyclic citrullinated peptide Human leukocyte antigen
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Hepatic fibrosis in patients diagnosed with rheumatoid arthritis and psoriatic arthritis receiving methotrexate:A cross-sectional analysis using transient elastography 认领 引用
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作者 Ratchaya Lertnawapan Soonthorn Chonprasertsuk +1 位作者 Sith Siramolpiwat Kanon Jatuworapruk 《Rheumatology & Autoimmunity》 2026年第1期51-56,共6页
Background:Among patients diagnosed with rheumatoid arthritis(RA)and psoriatic arthritis(PsA),several factors have been associated with hepatic fibrosis,including exposure to methotrexate(MTX)and metabolic syndrome.In... Background:Among patients diagnosed with rheumatoid arthritis(RA)and psoriatic arthritis(PsA),several factors have been associated with hepatic fibrosis,including exposure to methotrexate(MTX)and metabolic syndrome.In this study,we compared the prevalence of hepatic fibrosis in RA and PsA patients who had been taking MTX,and explored factors associated with hepatic fibrosis in these patients.Methods:Patients with RA or PsA who were treated with MTX and managed at the rheumatology clinic,Thammasat University Hospital,between November 2022 and December 2023 were included.Hepatic fibrosis was detected using transient elastography(TE).The prevalence of hepatic fibrosis was compared between the RA and PsA patients.Multivariable linear regression analysis was performed to determine the factors associated with hepatic fibrosis,with emphasis on metabolic syndrome and cumulative methotrexate dose.Results:Among the 295 recruited patients,185(62.7%)were diagnosed with RA and 110(37.2%)with PsA.Hepatic fibrosis detected by TE was found in 28.6%of RA patients and 45.5%of PsA patients,respectively.Higher prevalence of metabolic syndrome was observed in the PsA subgroup than that in RA subgroup.The linear regression analysis identified the association between hepatic fibrosis and metabolic syndrome(regression coefficient:4.127;95%confidence interval:3.389 to 4.864;p<0.001).Notably,cumulative MTX dose and MTX dose per body weight were not associated with hepatic fibrosis in the current analysis.Conclusions:Patients with PsA have a higher prevalence of metabolic syndrome and hepatic fibrosis than those with RA.Metabolic syndrome is associated with hepatic fibrosis,even after adjusting for MTX exposure and types of inflammatory arthritis. 展开更多
关键词 hepatic fibrosis metabolic syndrome psoriatic arthritis rheumatoid arthritis
Differential expression of plasma extracellular vesicle miRNAs as biomarkers for distinguishing psoriatic arthritis from psoriasis 认领 引用
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作者 Kexiang Yan Jie Zhu +9 位作者 Mengmeng Zhang Fuxin Zhang Bing Wang Ling Han Qiong Huang Yulong Tang Yuan Li Nikhil Yawalkar Zhenghua Zhang Zhenmin Niu 《Chinese Medical Journal》 SCIE CAS CSCD 2025年第2期219-221,共3页
To the Editor:Psoriatic arthritis(PsA)affects up to 30%of patients with psoriasis,contributing to a decreased quality of life.PsA can involve a variety of clinical manifestations,including peripheral and axial arthrit... To the Editor:Psoriatic arthritis(PsA)affects up to 30%of patients with psoriasis,contributing to a decreased quality of life.PsA can involve a variety of clinical manifestations,including peripheral and axial arthritis,enthesitis,dactylitis,and nail disease.[1]Early intervention is important for preventing loss of function and permanent disability;however,the diagnosis of PsA is often delayed by an average of five years.[1]Therefore,it is important to identify biomarkers that can detect PsA in patients with psoriasis. 展开更多
关键词 psoriasis identify biomarkers differential expression plasma extracellular vesicle psoriatic arthritis biomarkers
Effects of psoriatic arthritis‐targeted drugs on bone remodeling:Clinical evidence and molecular pathways 认领 引用
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作者 Yingchao Sun Cheng Xu +1 位作者 Mingli Ouyang Yongmei Han 《Rheumatology & Autoimmunity》 2025年第3期186-197,共12页
Psoriatic arthritis(PsA)is a chronic inflammatory disease characterized by diverse clinical manifestations.Of particular concern,osteopenia and osteoporosis are prevalent in 45.27%and 12.94%of PsA patients,respectivel... Psoriatic arthritis(PsA)is a chronic inflammatory disease characterized by diverse clinical manifestations.Of particular concern,osteopenia and osteoporosis are prevalent in 45.27%and 12.94%of PsA patients,respectively,suggesting a potential link between systemic inflammation and disrupted bone metabolism.While bone involvement in PsA has been widely investigated,a clear consensus on its underlying mechanisms and therapeutic implications remains lacking.Recent well‐designed randomized controlled trials have primarily examined the efficacy of targeted biologic therapies in managing PsA symptoms.However,their impact on bone remodeling—particularly the delicate balance between bone resorption and formation—is still not well understood.This review systematically assesses clinical evidence on bone mineral density changes in PsA patients compared to healthy controls and explores the molecular pathways through which targeted therapies(e.g.,tumor necrosis factor‐αinhibitors,interleukin‐17/23 blockers,and Janus kinase inhibitors)may influence bone remodeling.By bridging mechanistic insights with clinical findings,this study seeks to clarify the osteoimmunological effects of PsA treatments and provide direction for future translational research. 展开更多
关键词 biological DMARDs bone metabolism osteoporosis psoriatic arthritis targeted therapy
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