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Acquired ptosis associated with oculomotor and contralateral facial nerve synkinesis: the first reported case 认领 引用
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作者 Mauro Tarallo Magda Gharbiya +5 位作者 Maria Giuseppina Onestil Andrea Conversi Marco Toscani PasqualeFino Nicolo Scuderi Giuseppe Di Taranto 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第11期1783-1785,共3页
Dear Editor,Evidence of oculomotor nerve（ON）synkinesis is a common occurrence following both acquired and congenital III nerve palsy[1].It is generally accepted that aberrant regeneration is the likely aetiology of ... Dear Editor,Evidence of oculomotor nerve（ON）synkinesis is a common occurrence following both acquired and congenital III nerve palsy[1].It is generally accepted that aberrant regeneration is the likely aetiology of synkinesis in acquired III nerve palsy,following intracranial aneurysm,trauma, 展开更多
关键词 the first reported case Figure Acquired ptosis associated with oculomotor and contralateral facial nerve synkinesis
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Reported Cases and Deaths of National Notifiable Infectious Diseases—China,February 2025 认领 引用
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《China CDC weekly》 SCIE CSCD 2025年第14期489-490,共2页
According to the National Bureau of Disease Control and Prevention.The number of deaths of acquired immune deficiency syndrome(AIDS)is the number of all-cause deaths reported in the month by cumulative reported AIDS p... According to the National Bureau of Disease Control and Prevention.The number of deaths of acquired immune deficiency syndrome(AIDS)is the number of all-cause deaths reported in the month by cumulative reported AIDS patients.Since September 20,2023,Monkey pox was included in the management of Class B infectious diseases.Infectious diarrhea excludes cholera,dysentery,typhoid fever and paratyphoid fever. 展开更多
关键词 acquired immune deficiency syndrome aids deaths choleradysenterytyphoid fever February reported cases China paratyphoid fever national notifiable infectious diseases
Reported Cases and Deaths of National Notifiable Infectious Diseases—China,December 2024 认领 引用
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《China CDC weekly》 SCIE CSCD 2025年第6期230-231,共2页
According to the National Bureau of Disease Control and Prevention,not included coronavirus disease 2019(COVID-19).†The number of deaths of acquired immune deficiency syndrome(AIDS)is the number of all-cause deaths re... According to the National Bureau of Disease Control and Prevention,not included coronavirus disease 2019(COVID-19).†The number of deaths of acquired immune deficiency syndrome(AIDS)is the number of all-cause deaths reported in the month by cumulative reported AIDS patients.§Since September 20,2023,Monkey pox was included in the management of Class B infectious diseases.¶Infectious diarrhea excludes cholera,dysentery,typhoid fever and paratyphoid fever. 展开更多
关键词 acquired immune deficiency syndrome aids class b infectious diseases infectious diarrhea deaths choleradysenterytyphoid fever reported cases coronavirus disease paratyphoid fever national notifiable infectious diseases
Biliary stricture as an atypical presentation of type 2 autoimmune pancreatitis:A case report 认领 引用
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作者 Kai-Ruo Wang Su-Mei Sha +5 位作者 Shen-Hao Wang Ping Zhao Hai-Tao Shi Le Liu Jie Wu Gang Zhao 《World Journal of Gastroenterology》 SCIE CAS 2026年第16期146-150,共5页
BACKGROUND Type 2 autoimmune pancreatitis(AIP-2)is a rare immunoglobulin G4(IgG4)-negative inflammatory disease whose diagnosis is often challenging because it closely mimics pancreaticobiliary malignancies,frequently... BACKGROUND Type 2 autoimmune pancreatitis(AIP-2)is a rare immunoglobulin G4(IgG4)-negative inflammatory disease whose diagnosis is often challenging because it closely mimics pancreaticobiliary malignancies,frequently resulting in misdiagnosis and unnecessary surgery.CASE SUMMARY A 35-year-old man presented with obstructive jaundice.Imaging revealed pancreatic enlargement and a distal common bile duct stricture,whereas serum IgG4 levels were normal.Given the strong suspicion of malignancy,he underwent pancreaticoduodenectomy.Histopathological examination of the resected specimen revealed a fibrotic process with granulocytic epithelial lesions and rare IgG4-positive cells,confirming AIP-2.The thickened common bile duct wall was interpreted as a secondary change resulting from pancreatic inflammation.CONCLUSION AIP-2 must be considered in IgG4-negative obstructive jaundice with biliary stricture. 展开更多
关键词 Type 2 autoimmune pancreatitis Obstructive jaundice Pancreaticobiliary malignancy Surgery Case report
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Adult liver rhabdomyosarcoma complicated with sarcomatoid carcinoma:A case report 认领 引用
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作者 Jie-Qun Ma Chen Wang +4 位作者 Suo-Ni Li Qi Zheng Jie Bai Cai-Xia Ding Yan-Bing Zhang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第1期273-281,共9页
BACKGROUND Rhabdomyosarcoma(RMS)is a type of malignant tumor originating from rhabdomyocytes or mesenchymal cells differentiating into rhabdomyocytes.Hepatic pleomorphic RMS is a rare malignant liver tumor.Hepatic sar... BACKGROUND Rhabdomyosarcoma(RMS)is a type of malignant tumor originating from rhabdomyocytes or mesenchymal cells differentiating into rhabdomyocytes.Hepatic pleomorphic RMS is a rare malignant liver tumor.Hepatic sarcomatoid carcinoma is also a rare epithelial malignant tumor originating from the liver;it is characterized by the coexistence of both carcinomatous and sarcomatoid spindle cell components.CASE SUMMARY This paper reports a special case of an elderly woman whose initial liver puncture biopsy showed pleomorphic RMS.After chemotherapy with the vincristine+doxorubicin+cyclophosphamide regimen,the alpha-fetoprotein level increased significantly.Therefore,a second liver puncture was performed,the pathological result of which was hepatic sarcomatoid carcinoma.Next-generation sequencing revealed MET gene amplification with an average copy number of 9 in the tumor tissue;however,both fluorescence in situ hybridization and immunohistochemical tests were negative for MET amplification.The treatment regimen was adjusted to chemotherapy combined with immunotherapy;however,the disease progressed rapidly,and the overall survival was only 6 months.CONCLUSION By sharing the diagnosis and treatment process of this patient and reviewing the relevant literature,we aim to help clinicians enhance their understanding of two rare diseases,namely pleomorphic RMS and sarcomatoid carcinoma of the liver. 展开更多
关键词 Hepatic malignant neoplasm Pleomorphic rhabdomyosarcoma Sarcomatoid carcinoma Alpha-fetoprotein MET amplification Case report
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Rabson-Mendenhall syndrome caused by a novel splice-site mutation(c.1123+2 T>C)of insulin receptor:A case report and review of literature 认领 引用
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作者 Kun Wang Juan Zheng +4 位作者 Long-Chao Gu Rong-Rong Li Xu-Dong Su Jie Bai Lin Liao 《World Journal of Diabetes》 SCIE 2026年第1期211-220,共10页
BACKGROUND Rabson-Mendenhall syndrome(RMS)is an extremely rare monogenic form of diabetes caused by mutations in the insulin receptor(INSR)gene,with only about 50 cases reported worldwide to date.Here,we report a case... BACKGROUND Rabson-Mendenhall syndrome(RMS)is an extremely rare monogenic form of diabetes caused by mutations in the insulin receptor(INSR)gene,with only about 50 cases reported worldwide to date.Here,we report a case of RMS caused by a previously unreported c.1123+2 T>C splice mutation.CASE SUMMARY The patient was diagnosed with acanthosis nigricans and hypertrichosis at birth,and the growth rate was slower than that of normal children.At age 5,the patient had severe hyperinsulinemia,congenital heart abnormalities,and pineal cysts.At age 13,he was diagnosed with diabetes and exhibited symptoms of hyperinsulinemia,low body weight,growth retardation,acanthosis nigricans,dental anomalies,an oversized penis,and a pineal cyst.Sequencing results indicated an INSR c.1123+2 T>C mutation,and bioinformatic analysis suggested that this mutation led to splicing abnormalities,thereby affecting INSR function.Both parents carried the mutated gene,whereas his brother had a normal genotype.CONCLUSION Genetic diagnosis is vital in RMS;c.1123+2 T>C mutation of INSR causes pancreatic decline;current treatments show limited effectiveness. 展开更多
关键词 Rabson-Mendenhall syndrome Insulin receptor gene Splice mutation Hyperinsulinemia Case report
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Feasibility of water vapor thermal therapy for treating lower urinary tract symptoms in men with localized prostate cancer on active surveillance:a case series 认领 引用
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作者 Mustufa Babar Farooz Babar +2 位作者 Noah Hawks-Ladds Justin Loloi Michael Ciatto 《The Canadian Journal of Urology》 SCIE 2026年第1期193-199,共7页
Background:Prostate cancer is a common malignancy,with many men on active surveillance for localized,low-risk disease also experiencing lower urinary tract symptoms(LUTS)from benign prostatic hyperplasia(BPH).Water Va... Background:Prostate cancer is a common malignancy,with many men on active surveillance for localized,low-risk disease also experiencing lower urinary tract symptoms(LUTS)from benign prostatic hyperplasia(BPH).Water Vapor Thermal Therapy(WVTT)is a minimally invasive BPH treatment,but its safety and efficacy in this setting are unclear.Case Description:We report three men with localized PCa on active surveillance who underwent WVTT for LUTS.Conclusions:WVTT appears safe and potentially effective in treating LUTS,especially in those with lower-risk disease and smaller prostate volumes.Further research is needed to confirm safety,efficacy,and optimal patient selection. 展开更多
关键词 lower urinary tract symptoms benign prostatic hyperplasia prostatic neoplasms active surveillance case report
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Adolescent Renal Tumours:Diagnostic and Therapeutic Challenges in a Transitional Age Group-A Multidisciplinary Case Report Series from a Single Center 认领 引用
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作者 Antonio Ruggiero Fernando Fuccillo +8 位作者 Valerio Di Paola Alberto Romano Palma Maurizi Dario Talloa Nazario Foschi Pierluigi Russo Marco Racioppi Stefano Mastrangelo Giorgio Attinà 《Oncology Research》 SCIE 2026年第4期855-870,共16页
Background:The management of renal neoplasms in adolescent patients poses unique clinical challenges due to their transitional position between paediatric and adult populations.This age group exhibits marked heterogen... Background:The management of renal neoplasms in adolescent patients poses unique clinical challenges due to their transitional position between paediatric and adult populations.This age group exhibits marked heterogeneity in tumour histology,ranging from entities commonly observed in paediatric oncology to tumours typical of adult age,as well as rare histological subtypes that exceptionally affect the kidney.Given the substantial differences in clinical protocols between paediatric and adult populations,rigorous multidisciplinary evaluation is essential to determine optimal diagnostic and therapeutic strategies for adolescent patients.Case Description:We present four cases from our tertiary referral centre that illustrate the variability in radiological and histopathological presentations and clinical outcomes in this population,underscoring the critical importance of a multidisciplinary approach.Case 1 demonstrates the typical management of Wilms’tumour in an older paediatric patient.Case 2 exemplifies the diagnostic challenge of distinguishing between Wilms’tumour and renal cell carcinoma at the upper end of the adolescent spectrum.Case 3 revealed the unexpected diagnosis of renal Ewing sarcoma in a 13-year-old female.Case 4 highlights the potential for severe perioperative complications,including life-threatening thromboembolic events,in a patient with Wilms’tumour.Conclusions:The variability in tumour types,biological behaviour,and potential for severe complications underscores the necessity of comprehensive multidisciplinary management in specialized hospital settings.An integrated approach ensures accurate diagnosis,individualized treatment planning,and effective management of complications,ultimately optimizing outcomes for adolescent patients with renal neoplasms. 展开更多
关键词 Paediatric oncology adolescent oncology renal tumours Wilms’tumour(WT) renal cell carcinoma(RCC) case report
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Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient:A case report and review of literature 认领 引用
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作者 Daisuke Usuda Daiki Furukawa +23 位作者 Rikako Imaizumi Rikuo Ono Yuki Kaneoka Eri Nakajima Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita 《World Journal of Clinical Cases》 2026年第1期34-42,共9页
BACKGROUND Edwardsiella tarda(E.tarda)belongs to the family Enterobacteriaceae and is generally seen to cause infections mainly in fish,but is also capable of infecting humans.Extraintestinal infections occur in patie... BACKGROUND Edwardsiella tarda(E.tarda)belongs to the family Enterobacteriaceae and is generally seen to cause infections mainly in fish,but is also capable of infecting humans.Extraintestinal infections occur in patients with certain risk factors,including immunocompromised status.We recently diagnosed a case of spontaneous bacterial peritonitis(SBP)due to E.tarda in an immuno-compromised dialysis patient.CASE SUMMARY Patient was a 55-year-old male,with a history of diabetic nephropathy being treated with hemodialysis three times a week.He was referred to our hospital due to an increased volume of ascites,and blood examination revealed increased inflammatory reaction.At our emergency department,he developed fever,disturbance of consciousness,abdominal distension,and abdomen-wide pain.In addition,a dialysis shunt was confirmed in his right forearm,and the shunt site showed no signs of inflammation.No wounds were confirmed on or in his body.A blood examination revealed increased values of white blood cells,C-reactive protein,and creatinine.Plain chest and abdominal computed tomography scanning revealed increased ascites volume.Abdominal paracentesis was performed and a Gram stain revealed Gramnegative bacillus.These findings prompted diagnosis of SBP.The patient was admitted and treated with cefmetazole,causing fever resolution and symptom improvements.Later,E.tarda was identified in ascites culture.The patient improved with decreased inflammatory response and was discharged on the 12th day of hospitalization.The antibiotic was terminated after 14 days of treatment.SBP in this case may have developed from chronic renal failure and diabetes mellitus.CONCLUSION We report the first known case of SBP due to E.tarda in an immuno-compromised dialysis patient. 展开更多
关键词 Spontaneous bacterial peritonitis Edwardsiella tarda Immunocompromised status Hemodialysis Treatment Case report
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Phrenic nerve capture caused by atrial electrode dislodgement:A case report 认领 引用
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作者 Xue-Song Zhang Fei Wang +3 位作者 Xue-Wen Qi Pella Shafii Xiao-Ning Cui Yue-Hai Wang 《World Journal of Cardiology》 2026年第4期112-118,共7页
BACKGROUND Atrial electrode lead dislodgment leading to phrenic nerve capture is rare.CASE SUMMARY An elderly man with third-degree atrioventricular block underwent dual-chamber pacemaker implantation.During the proce... BACKGROUND Atrial electrode lead dislodgment leading to phrenic nerve capture is rare.CASE SUMMARY An elderly man with third-degree atrioventricular block underwent dual-chamber pacemaker implantation.During the procedure,both leads were introduced through the same venous puncture site.A passive lead was positioned in the atrium,and an active lead was positioned in the ventricle.On postoperative day 3,the patient developed diaphragmatic flutter.Electrocardiography demonstrated poor atrial sensing.Repeat chest radiography and computed tomography revealed displacement of the atrial lead compared with its immediate postoperative position,while the ventricular lead remained stable.Device interrogation confirmed abnormal atrial sensing.The frequency of diaphragmatic flutter varied according to the programmed atrial pacing rate,whereas ventricular sensing and pacing thresholds were normal.After reprogramming the device to ventricular inhibited pacing mode,the diaphragmatic flutter resolved completely.CONCLUSION Atrial electrode lead displacement may capture the phrenic nerve,leading to diaphragmatic flutter. 展开更多
关键词 Dual-chamber pacemaker Shared puncture site Atrial lead dislodgement Diaphragmatic flutter Phrenic nerve capture Case report
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Excellent Survival Outcome in a Patient Receiving NALIRIFOX for Metastatic Pancreatic Adenocarcinoma:A Case Report 认领 引用
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作者 Abdullah Esmail Waseem Abdelrahim +2 位作者 Ebtesam Al-Najjar Raed Zaidan Tahrir Abdelrahim 《Oncology Research》 SCIE 2026年第8期605-614,共10页
Background:Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignancy that is frequently diagnosed at an advanced stage and remains associated with poor survival outcomes.Durable responses to systemic therapy i... Background:Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignancy that is frequently diagnosed at an advanced stage and remains associated with poor survival outcomes.Durable responses to systemic therapy in metastatic disease are uncommon.We report a case of metastatic PDAC with prolonged survival and sustained response following first-line treatment with NALIRIFOX.This report describes a patient with metastatic PDAC who achieved prolonged disease control and sustained response following first-line treatment with NALIRIFOX.Case Presentation:A 64-year-old woman presented with abdominal pain,early satiety,weight loss,and markedly elevated CA 19-9 levels.Imaging demonstrated a pancreatic head mass with multiple hepatic metastases,and biopsy confirmed metastatic poorly differentiated PDAC.The patient initiated first-line therapy with NALIRIFOX as part of the NAPOLI-3 protocol and completed 20 cycles over approximately 25 months.Following an early treatment delay secondary to grade 2 neutropenia,she achieved substantial biochemical and radiographic improvement.After eight cycles,imaging demonstrated marked radiographic response with disappearance of the pancreatic lesion and marked regression of hepatic metastases.Disease stability was maintained for more than two years before progression was identified in a dominant hepatic lesion after cycle 20.Conclusion:This case highlights the potential for prolonged disease control and extended survival with NALIRIFOX in metastatic PDAC,emphasizing the meaningful clinical benefit that may be achieved in selected patients despite historically poor outcomes. 展开更多
关键词 NALIRIFOX long-term survival pancreatic ductal adenocarcinoma durable response case report
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Orbital Metastases of Breast Cancer:Case Report and Review of the Literature 认领 引用
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作者 Teng Zhu Siwen Zang Bo Chen 《Oncology Research》 SCIE 2026年第6期769-780,共12页
Background:Orbital metastases are rare in breast cancer,representing only 3–10%of ocular metastases.This report highlights a case where orbital involvement was the first indicator of systemic metastatic spread.Case P... Background:Orbital metastases are rare in breast cancer,representing only 3–10%of ocular metastases.This report highlights a case where orbital involvement was the first indicator of systemic metastatic spread.Case Presentation:A 72-year-old woman with a history of Estrogen Receptor(ER)-positive(5%),Progesterone Receptor(PR)-negative,Human epidermal growth factor receptor-2(HER2)-negative breast cancer(diagnosed 3 years prior)presented with right orbital pain,diplopia,and periorbital swelling.Imaging revealed multiple myositis of the extraocular muscles,compressive displacement of the optic nerve,and right periorbital edema.Bone scintigraphy identified multifocal skeletal metastases.A navigation-assisted biopsy confirmed metastatic invasive ductal carcinoma,immunohistochemically consistent with the primary tumor(ER/PR-negative,HER2-negative).A systematic analysis using next-generation sequencing indicated aberrant activation of the phosphoinositide 3 kinase(PI3K)/AKT/mammalian target of rapamycin(mTOR)signaling pathway.Chemotherapy,targeted therapy and bisphosphonate therapy were initiated,with planned radiotherapy for symptomatic progression.Conclusion:Orbital symptoms in breast cancer survivors,even subtle ones,necessitate prompt evaluation for metastatic disease.Multimodal imaging(e.g.,Computed Tomography(CT)/Magnetic Resonance Imaging(MRI))combined with image-guided biopsy is critical for diagnosis.Early detection enables multidisciplinary palliative strategies to optimize quality of life while addressing systemic dissemination. 展开更多
关键词 Orbital metastasis breast cancer navigation-assisted biopsy palliative therapy skeletal metastases case report
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Electroacupuncture for sperm improvement in varicocele:a case report 认领 引用
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作者 Ida Nurwati Uki Retno Budihastuti +2 位作者 Bhisma Murti Teguh Prakosa Metanolia Sukmawati 《The Canadian Journal of Urology》 SCIE 2026年第2期489-495,共7页
Background:Varicocele is a common cause of male infertility,often associated with impaired sperm quality,hormonal imbalance,and increased DNA fragmentation.Electroacupuncture(EA)has been proposed as an adjunct therapy... Background:Varicocele is a common cause of male infertility,often associated with impaired sperm quality,hormonal imbalance,and increased DNA fragmentation.Electroacupuncture(EA)has been proposed as an adjunct therapy to improve reproductive parameters,but clinical evidence remains limited.Case Description:This case report describes a 38-yearold male with a varicocele treated at Dr.Moewardi General Hospital,Indonesia.The patient underwent 16 sessions of EA therapy.Sperm parameters and serum testosterone levels were measured before and after treatment.Following EA,sperm concentration improved from 5.2 to 6.7×106/mL,motility increased from 43%to 60%,and normal morphology rose from 1%to 3%.Testosterone levels increased from 329.6 to 596.2 ng/dL,while the DNA Fragmentation Index(DFI)decreased from 40%to 19.6%.Conclusions:This case suggests that EA therapy may improve sperm quality,enhance testosterone levels,and reduce DFI in a patientwith varicocele.However,further controlled studies are needed to confirm these findings due to the limitations of a single case report. 展开更多
关键词 electroacupuncture infertility sperm motility case report
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Long-term disease-free survival following preoperative diagnosis and laparoscopic radical resection for Meckel’s diverticulum adenocarcinoma:A case report 认领 引用
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作者 Ze-Hao Yu Chun-Run Ling +2 位作者 Jun-Ying Yu Qiu-Huan Zhang Shan-Shan Wei 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第1期403-410,共8页
BACKGROUND Meckel’s diverticulum(MD)is most commonly encountered during emergency interventions for complications or as an incidental finding during an unrelated procedure.Definitive pre-operative diagnosis of MD-ass... BACKGROUND Meckel’s diverticulum(MD)is most commonly encountered during emergency interventions for complications or as an incidental finding during an unrelated procedure.Definitive pre-operative diagnosis of MD-associated adenocarcinoma,permitting radical resection,is very rare in clinical practice.CASE SUMMARY A 36-year-old male presented with recurrent dark-red hematochezia.Initial gastroscopy,colonoscopy,computed tomography,and tumor marker assessments were unremarkable.A technetium-99m pertechnetate Meckel scan(Meckel scan)revealed ectopic gastric mucosa,suggesting an MD.Double-balloon enteroscopy revealed an ulcerative stricture in the ileum,and biopsy confirmed a moderately differentiated adenocarcinoma.The patient underwent laparoscopic radical small bowel resection.Histopathology confirmed pT3N0M0,stage ⅡA(the American Joint Committee on Cancer 8th edition)moderately differentiated adenocarcinoma with lymphovascular invasion.Adjuvant chemotherapy was administered postoperatively.No recurrence or metastasis was observed during a 36-month followup.CONCLUSIONFor recurrent obscure gastrointestinal hemorrhage, combined Meckel scan and double-balloon enteroscopy iscritical for diagnosing MD-associated, enabling curative resection. 展开更多
关键词 Meckel’s-diverticulum-associated adenocarcinoma Pre-operative diagnosis Technetium-99m pertechnetate Meckel scan Double-balloon enteroscopy Radical resection Case report
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Endoscopic ultrasound-guided transhepatic antegrade stone removal for choledocholithiasis after pancreaticoduodenectomy:A case report and review of literature 认领 引用
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作者 Yu-Ming Li Aimaiti Yasen +4 位作者 Si-Fang Chen Jian Fan Xiao-Bing Huang Guo-Hua Zuo Lu Zheng 《World Journal of Gastroenterology》 SCIE CAS 2026年第8期146-153,共8页
BACKGROUND The special choledocholithiasis(common hepatic duct stone)proximal to hepaticojejunostomy anastomosis following pancreaticoduodenectomy(PD)presents significant therapeutic challenges because of surgically a... BACKGROUND The special choledocholithiasis(common hepatic duct stone)proximal to hepaticojejunostomy anastomosis following pancreaticoduodenectomy(PD)presents significant therapeutic challenges because of surgically altered anatomy,which precludes the use of conventional endoscopic retrograde cholangiopancreatography.Endoscopic ultrasound(EUS)offers a minimally invasive alternative for antegrade stone extraction.Here,we report a rare case of EUS-guided transhepatic antegrade stone removal(EUS-TASR)in a patient with choledocholithiasis occurring eleven years after PD.CASE SUMMARY A 58-year-old male with a history of PD for a duodenal tumor eleven years prior presented with a three-month history of intermittent upper abdominal discomfort.Imaging revealed a nodular filling defect in the common hepatic duct and mild intrahepatic biliary dilatation,confirming choledocholithiasis.Given the altered anatomy,endoscopic retrograde cholangiopancreatography was deemed unfeasible;thus,EUS-TASR with endoscopic nasobiliary drainage was successfully performed.The endoscopic nasobiliary drainage tube was removed on postoperative day 7,and the patient was discharged in stable condition on postoperative day 8.At the ten-month follow-up,the patient remained asymptomatic without complications.CONCLUSION EUS-TASR is a viable,minimally invasive approach for managing choledocholithiasis in post-PD patients with altered anatomy where conventional endoscopic access is restricted. 展开更多
关键词 Choledocholithiasis Pancreaticoduodenectomy Endoscopic ultrasound Endoscopic ultrasound-guided transhepatic antegrade stone removal Case report
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Successful conversion therapy for advanced hepatocellular carcinoma with biliary tumor thrombus and bilateral lobe involvement:A case report 认领 引用
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作者 Yu Zhang Lu-Yang Zhang +4 位作者 Bo Meng Yun-Jian Wang Nan-Mu Yang Qiong Li Min Zhang 《World Journal of Gastroenterology》 SCIE CAS 2026年第24期133-138,共6页
BACKGROUND Bilateral multilobular hepatocellular carcinoma(HCC)complicated by HCCderived biliary tumor thrombus is classified as an advanced-stage disease.Owing to the heavy tumor burden,obstructive jaundice,and other... BACKGROUND Bilateral multilobular hepatocellular carcinoma(HCC)complicated by HCCderived biliary tumor thrombus is classified as an advanced-stage disease.Owing to the heavy tumor burden,obstructive jaundice,and other issues,the prognosis with conventional treatment is extremely poor,and most patients lose the opportunity for radical resection.The advent of immune-combined targeted conversion therapy has brought new hope for such patients.CASE SUMMARY A 36-year-old man with≥10-year history of hepatitis B was admitted for upper abdominal distension and pain.Imaging demonstrated bilateral multifocal HCC with a left HCC-derived biliary tumor thrombus(Chinese Liver Cancer stage IIIa,Barcelona Clinic Liver Cancer stage C),obstructive jaundice,and cirrhosis.The tumor was initially considered unresectable.The patient received conversion therapy with camrelizumab,apatinib mesylate,and radiofrequency ablation.After five cycles,both the tumors and thrombus regressed,and tumor marker levels decreased markedly.The response was assessed as partial response according to mRECIST 1.1 criteria.Liver function improved from Child-Pugh class B to class A,allowing radical surgical resection with negative margins.Postoperative maintenance therapy was administered for 1 year.No recurrence CONCLUSION For advanced bilateral multi-lobular HCC complicated by HCC-derived biliary tumor thrombus,immune-targeted therapy combined with local ablation reduces tumor burden,eliminates thrombus,converts unresectable disease to resectable status,and achieves effective short-term disease control. 展开更多
关键词 Hepatocellular carcinoma Hepatocellular carcinoma-derived biliary tumor thrombus Conversion therapy Immunotherapy Targeted therapy Case report
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Rapid progression to liver failure following pancreatoduodenectomy in an adolescent:A case report 认领 引用
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作者 Han Hu Yu-Juan Liu +2 位作者 Mei-Chuan Li Yan Li Shi-De Lin 《World Journal of Gastroenterology》 SCIE CAS 2026年第29期142-149,共8页
BACKGROUND Pancreatoduodenectomy(PD)is a major surgical intervention that frequently leads to pancreatic exocrine insufficiency and subsequent malnutrition.A recognized but often indolent complication in adults is the... BACKGROUND Pancreatoduodenectomy(PD)is a major surgical intervention that frequently leads to pancreatic exocrine insufficiency and subsequent malnutrition.A recognized but often indolent complication in adults is the development of malnutrition-associated steatohepatitis.While rare instances of progression to cirrhosis have been reported in adults,the trajectory of post-PD hepatic complications in pediatric and adolescent populations remains largely uncharacterized.This population’s unique physiological demands for growth and development may predispose them to more aggressive disease phenotypes.CASE SUMMARY We present the case of a 14-year-old male patient who underwent a pyloruspreserving PD in July 2019 for a benign solid-cystic lesion of the pancreatic head.The postoperative course was complicated by severe pancreatic exocrine insufficiency,manifesting as intractable steatorrhea and profound,progressive malnutrition,which was less effectively controlled possibly due to both insufficient enzyme replacement and poor adherence to pancreatic enzyme replacement therapy.Four years after surgery(June 2023),he developed hepatic steatosis that rapidly progressed to decompensated cirrhosis with portal hypertension.Despite aggressive nutritional rehabilitation and optimized pancreatic enzyme replacement therapy,his clinical condition continued to decline.He was readmitted in March 2025 with acute-on-chronic liver failure,culminating in multi-organ failure and death in April 2025,less than six years after his initial surgery.This case represents a rarely documented instance of fatal,rapidly progressive malnutritionassociated steatohepatitis leading to liver failure in an adolescent following PD.CONCLUSION Adolescent patients can progress to cirrhosis and liver failure post-pylorus-preserving PD,necessitating intensified dynamic monitoring of nutritional status and liver function. 展开更多
关键词 Adolescent Pylorus-preserving pancreatoduodenectomy Pancreatic exocrine insufficiency Steatohepatitis Cirrhosis Acute-on-chronic liver failure Case report
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Dual Immune Checkpoint Blockade in Synchronous Hepatocellular and Renal Cell Carcinoma:A Real-World Case Report of Durable Dual Response 认领 引用
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作者 Piera Federico Maria Anna Canciello +2 位作者 Barbara Granata Davide Bosso Bruno Daniele 《Oncology Research》 SCIE 2026年第7期713-723,共11页
Background:The synchronous occurrence of hepatocellular carcinoma(HCC)and clear cell renal cell carcinoma(ccRCC)is rare and poses significant therapeutic challenges,particularly in elderly patients with comorbidities.... Background:The synchronous occurrence of hepatocellular carcinoma(HCC)and clear cell renal cell carcinoma(ccRCC)is rare and poses significant therapeutic challenges,particularly in elderly patients with comorbidities.Although both malignancies may respond to immune checkpoint inhibitors(ICIs),evidence supporting a unified immunotherapeutic approach remains limited.This report aims to describe the clinical course and outcomes of dual immune checkpoint blockade(ICB)in a patient with synchronous HCC and ccRCC.Case Description:We describe a patient in their 80s with synchronous advanced HCC and ccRCC,with underlying cirrhosis related to hepatitis C virus infection and cardiovascular comorbidities.Following multidisciplinary evaluation,treatment with nivolumab plus ipilimumab was initiated.Early radiologic assessment demonstrated a partial response in the renal lesion and an apparent increase in the hepatic lesion,consistent with pseudoprogression.Continued therapy led to progressive reduction of the hepatic lesion and sustained control of the renal tumor.At approximately 18 months of follow-up,both lesions showed durable radiologic response with excellent tolerability and no immune-related adverse events.At the time of writing(April 2026),the patient remains on treatment.Conclusions:This case highlights the feasibility and potential efficacy of a unified immunotherapeutic strategy in synchronous immunogenic malignancies.It also underscores the importance of careful interpretation of radiologic findings during immunotherapy,particularly in HCC where atypical response patterns such as pseudoprogression may occur.These findings provide real-world insight into personalized immunotherapy approaches for complex oncologic scenarios. 展开更多
关键词 Renal cell carcinoma hepatocellular carcinoma dual checkpoint blockade synchronous immunogenic tumors case report
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Incisional mesh hernioplasty following spontaneous stoma closure:A case report 认领 引用
19
作者 Wen Ai Zhi-Hua Liang Bo Liu 《World Journal of Gastroenterology》 SCIE CAS 2026年第26期149-154,共6页
BACKGROUND Loop stoma is usually used to divert the fecal stream,with the aim of protecting the downstream anastomosis or allowing sufficient time for the repaired perforation site to heal.It is usually reversed once ... BACKGROUND Loop stoma is usually used to divert the fecal stream,with the aim of protecting the downstream anastomosis or allowing sufficient time for the repaired perforation site to heal.It is usually reversed once the purpose of its creation is served.Spontaneous stoma closure is a rare phenomenon,and its mechanism remains unclear.The factors contributing to this phenomenon encompass stoma retraction and the healing process of enterocutaneous fistula.CASE SUMMARY We present a case of mesh hernioplasty after the spontaneous closure of a transverse loop colostomy.This is the third case of spontaneous closure of loop colostomy and the first reported case of mesh hernioplasty following the spontaneous stoma closure in the English literature.CONCLUSION Spontaneous stoma closure is rare.Long-term follow-up is recommended to detect the development of incisional hernia at an early stage. 展开更多
关键词 Colostomy Incisional Mesh hernioplasty Retraction Spontaneous closure Case report
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Perforative peritonitis caused by long-term retention of a rectal foreign body:A case report 认领 引用
20
作者 Daisuke Usuda Daiki Furukawa +24 位作者 Rikako Imaizumi Rikuo Ono Yuki Kaneoka Eri Nakajima Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita 《World Journal of Clinical Cases》 2026年第11期41-48,共8页
BACKGROUND Rectal foreign bodies(RFBs),mostly due to self-insertion for sexual pleasure,are occasionally encountered in emergency departments.They are more common in young male patients,and because patients often dela... BACKGROUND Rectal foreign bodies(RFBs),mostly due to self-insertion for sexual pleasure,are occasionally encountered in emergency departments.They are more common in young male patients,and because patients often delay seeking medical attention due to embarrassment,complications such as perforation and peritonitis may be present at diagnosis.Emergency physicians must remain mindful of potential RFB insertion and conduct history-taking and physical examinations with sensitivity to patient embarrassment.Reports of penetrating peritonitis caused by long-term RFB retention are rare.CASE SUMMARY A 16-year-old male experienced persistent fever of approximately 38°C for 35 days.Although antipyretics and antibiotics were prescribed at a local clinic,his symptoms did not improve.Later,he disclosed that his condition had worsened after inserting a smartphone stand into his rectum 35 days before for sexual gratification,and he was referred to our hospital.Upon arrival,his vital signs were stable,and mild tenderness was noted in the left lower abdomen.Laboratory tests revealed leukocytosis and elevated C-reactive protein levels(5.21 mg/dL).Abdominal computed tomography revealed a spring-like foreign body and a large amount of fecal material in the rectum.Endoscopic removal was unsuccessful;therefore,laparotomy was performed for object extraction.Intraoperatively,the rectum was found to have perforated into the retroperitoneal cavity.The postoperative course was uneventful,and the patient was discharged 11 days after admission.CONCLUSION We report a case of penetrating peritonitis after long-term RFB retention,without an acute abdomen,because the perforation was retroperitoneal. 展开更多
关键词 Rectal foreign body Perforative peritonitis Long-term retention Etiology Management Case report
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